Location Start End Strand Length PID Gene Synonym COG sanger_anot Possible.DR.phage.PEPPE. essential. Annotation Filter_criteria Filter 1..1524 1 1524 + 507 15607143 dnaA Rv0001 COG0593L II.A.5 essential chromosomal replication initiation protein KEEP 1525..2051 1525 2051 I NA NA IG1_Rv0001-Rv0002 KEEP 2052..3260 2052 3260 + 402 15607144 dnaN Rv0002 COG0592L II.A.5 nonessential DNA polymerase III subunit beta KEEP 3261..3279 3261 3279 I NA NA IG2_Rv0002-Rv0003 KEEP 3280..4437 3280 4437 + 385 15607145 recF Rv0003 COG1195L II.A.5 nonessential recombination protein F KEEP 4434..4997 4434 4997 + 187 15607146 - Rv0004 COG5512R V nonessential hypothetical protein KEEP 4998..5122 4998 5122 I NA NA IG4_Rv0004-Rv0005 KEEP 5123..7267 5123 7267 + 714 15607147 gyrB Rv0005 COG0187L II.A.5 DR-flq essential DNA gyrase subunit B KEEP 7268..7301 7268 7301 I NA NA IG5_Rv0005-Rv0006 KEEP 7302..9818 7302 9818 + 838 15607148 gyrA Rv0006 COG0188L II.A.5 DR-flq nonessential DNA gyrase subunit A KEEP 9819..9913 9819 9913 I NA NA IG6_Rv0006-Rv0007 KEEP 9914..10828 9914 10828 + 304 15607149 - Rv0007 - II.C.5 nonessential hypothetical protein KEEP 10829..11873 10829 11873 I NA NA IG7_Rv0007-Rv0008c KEEP 11874..12311 11874 12311 - 145 15607150 - Rv0008c - II.C.5 nonessential hypothetical protein KEEP 12312..12467 12312 12467 I NA NA IG8_Rv0008c-Rv0009 KEEP 12468..13016 12468 13016 + 182 15607151 ppiA Rv0009 COG0652O II.A.6 nonessential iron-regulated peptidyl-prolyl cis-trans isomerase A KEEP 13017..13132 13017 13132 I NA NA IG9_Rv0009-Rv0010c KEEP 13133..13558 13133 13558 - 141 15607152 - Rv0010c - II.C.4 nonessential hypothetical protein KEEP 13559..13713 13559 13713 I NA NA IG10_Rv0010c-Rv0011c KEEP 13714..13995 13714 13995 - 93 15607153 - Rv0011c - II.C.5 nonessential putative septation inhibitor protein KEEP 13996..14088 13996 14088 I NA NA IG11_Rv0011c-Rv0012 KEEP 14089..14877 14089 14877 + 262 15607154 - Rv0012 COG3879S III.C nonessential hypothetical protein KEEP 14878..14913 14878 14913 I NA NA IG12_Rv0012-Rv0013 KEEP 14914..15612 14914 15612 + 232 57116682 trpG Rv0013 COG0512EH I.G.2 nonessential para-aminobenzoate synthase component II KEEP 15590..17470 15590 17470 - 626 15607156 pknB Rv0014c COG0515RTKL,COG2815S I.J.3 essential transmembrane serine/threonine-protein kinase B PKNB (protein kinase B) (STPK B) KEEP 17467..18762 17467 18762 - 431 15607157 pknA Rv0015c COG0515RTKL I.J.3 essential transmembrane serine/threonine-protein kinase A PKNA (protein kinase A) (STPK A) KEEP 18759..20234 18759 20234 - 491 15607158 pbpA Rv0016c COG0768M II.C.3 nonessential penicillin-binding protein PbpA KEEP 20231..21640 20231 21640 - 469 15607159 rodA Rv0017c COG0772D II.C.3 nonessential cell division protein RodA KEEP 21637..23181 21637 23172 - 514 15607160 ppp Rv0018c COG0631T I.J.3 nonessential serine/threonine phosphatase KEEP 21637..23181 23173 23181 - 514 15607160 ppp Rv0018c COG0631T I.J.3 nonessential serine/threonine phosphatase Only Marin et al 2022 KEEP 23182..23269 23182 23238 I NA NA IG18_Rv0018c-Rv0019c Only Marin et al 2022 KEEP 23182..23269 23239 23269 I NA NA IG18_Rv0018c-Rv0019c KEEP 23270..23737 23270 23737 - 155 15607161 - Rv0019c COG1716T V nonessential hypothetical protein KEEP 23738..23860 23738 23860 I NA NA IG19_Rv0019c-Rv0020c KEEP 23861..25444 23861 24719 - 527 15607162 TB39.8 Rv0020c COG1716T V nonessential hypothetical protein KEEP 23861..25444 24720 24738 - 527 15607162 TB39.8 Rv0020c COG1716T V nonessential hypothetical protein Only Marin et al 2022 KEEP 23861..25444 24739 25444 - 527 15607162 TB39.8 Rv0020c COG1716T V nonessential hypothetical protein KEEP 25445..25912 25445 25912 I NA NA IG20_Rv0020c-Rv0021c KEEP 25913..26881 25913 26881 - 322 15607163 - Rv0021c COG2070R V nonessential hypothetical protein KEEP 26882..27022 26882 27022 I NA NA IG21_Rv0021c-Rv0022c KEEP 27023..27442 27023 27442 - 139 15607164 whiB5 Rv0022c - I.J.1 nonessential transcriptional regulatory protein WHIB-like WHIB5 KEEP 27443..27594 27443 27594 I NA NA IG22_Rv0022c-Rv0023 KEEP 27595..28365 27595 28365 + 256 15607165 - Rv0023 COG1396K I.J.1 nonessential transcriptional regulatory protein KEEP 28362..29207 28362 29207 + 281 15607166 - Rv0024 COG0791M IV.A nonessential putative secreted protein P60-related protein KEEP 29208..29244 29208 29244 I NA NA IG24_Rv0024-Rv0025 KEEP 29245..29607 29245 29607 + 120 15607167 - Rv0025 - V nonessential hypothetical protein KEEP 29608..29721 29608 29721 I NA NA IG25_Rv0025-Rv0026 KEEP 29722..31068 29722 31068 + 448 15607168 - Rv0026 - V nonessential hypothetical protein KEEP 31069..31188 31069 31188 I NA NA IG26_Rv0026-Rv0027 KEEP 31189..31506 31189 31506 + 105 15607169 - Rv0027 - VI nonessential hypothetical protein KEEP 31507..31513 31507 31513 I NA NA IG27_Rv0027-Rv0028 KEEP 31514..31819 31514 31819 + 101 15607170 - Rv0028 - VI nonessential hypothetical protein KEEP 31820..32056 31820 32056 I NA NA IG28_Rv0028-Rv0029 KEEP 32057..33154 32057 33154 + 365 15607171 - Rv0029 - V nonessential hypothetical protein KEEP 33155..33223 33155 33223 I NA NA IG29_Rv0029-Rv0030 KEEP 33224..33553 33224 33553 + 109 15607172 - Rv0030 - VI nonessential hypothetical protein KEEP 33554..33581 33554 33581 I NA NA IG30_Rv0030-Rv0031 KEEP 33582..33794 33582 33794 + 70 15607173 - Rv0031 - IV.B.1 phage nonessential remnant of A transposase KEEP 33795..34294 33795 34294 I NA NA IG31_Rv0031-Rv0032 KEEP 34295..36610 34295 36610 + 771 15607174 bioF2 Rv0032 COG0156H I.G.1 nonessential 8-amino-7-oxononanoate synthase BioF2 KEEP 36607..36870 36607 36870 + 87 15607175 acpA Rv0033 COG0236IQ I.H.1 nonessential acyl carrier protein AcpA KEEP 36867..37262 36867 37262 + 131 15607176 - Rv0034 COG3631R V nonessential hypothetical protein KEEP 37259..38947 37259 38947 + 562 57116683 fadD34 Rv0035 COG0318IQ I.A.3 nonessential fatty-acid-CoA ligase KEEP 38948..39055 38948 39028 I NA NA IG35_Rv0035-Rv0036c KEEP 38948..39055 39029 39030 I NA NA IG35_Rv0035-Rv0036c Marin et al 2022 + homoplasy analysis DISCARD 38948..39055 39031 39055 I NA NA IG35_Rv0035-Rv0036c KEEP 39056..39829 39056 39829 - 257 15607178 - Rv0036c - V nonessential hypothetical protein KEEP 39830..39876 39830 39876 I NA NA IG36_Rv0036c-Rv0037c KEEP 39877..41202 39877 41202 - 441 15607179 - Rv0037c COG0477GEPR II.C.5 nonessential integral membrane protein KEEP 41203..41303 41203 41303 I NA NA IG37_Rv0037c-Rv0038 KEEP 41304..41912 41304 41912 + 202 15607180 - Rv0038 COG1678K V nonessential hypothetical protein KEEP 41913..42003 41913 42003 I NA NA IG38_Rv0038-Rv0039c KEEP 42004..42351 42004 42351 - 115 15607181 - Rv0039c - II.C.5 nonessential transmembrane protein KEEP 42352..42432 42352 42432 I NA NA IG39_Rv0039c-Rv0040c KEEP 42433..43365 42433 43365 - 310 57116684 mtc28 Rv0040c - VI nonessential secreted proline rich protein MTC28 (proline rich 28 kDa antigen) KEEP 43366..43561 43366 43561 I NA NA IG40_Rv0040c-Rv0041 KEEP 43562..46471 43562 46471 + 969 15607183 leuS Rv0041 COG0495J II.A.3 essential leucyl-tRNA synthetase KEEP 46472..46580 46472 46580 I NA NA IG41_Rv0041-Rv0042c KEEP 46581..47207 46581 47207 - 208 15607184 - Rv0042c COG1846K I.J.1 nonessential MarR family transcriptional regulator KEEP 47208..47365 47208 47365 I NA NA IG42_Rv0042c-Rv0043c KEEP 47366..48100 47366 48100 - 244 15607185 - Rv0043c COG1802K I.J.1 nonessential GntR family transcriptional regulator KEEP 48101..48232 48101 48232 I NA NA IG43_Rv0043c-Rv0044c KEEP 48233..49027 48233 49027 - 264 15607186 - Rv0044c COG2141C I.B.7 nonessential oxidoreductase KEEP 49028..49042 49028 49042 I NA NA IG44_Rv0044c-Rv0045c KEEP 49043..49939 49043 49939 - 298 15607187 - Rv0045c COG0596R I.H.3 nonessential hydrolase KEEP 49940..50020 49940 50020 I NA NA IG45_Rv0045c-Rv0046c KEEP 50021..51124 50021 51124 - 367 15607188 ino1 Rv0046c COG1260I VII nonessential myo-inositol-1-phosphate synthase INO1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase) KEEP 51125..51184 51125 51184 I NA NA IG46_Rv0046c-Rv0047c KEEP 51185..51727 51185 51727 - 180 15607189 - Rv0047c COG1695K V nonessential hypothetical protein KEEP 51728..51827 51728 51827 I NA NA IG47_Rv0047c-Rv0048c KEEP 51828..52697 51828 52697 - 289 15607190 - Rv0048c - II.C.5 nonessential hypothetical protein KEEP 52698..52830 52698 52830 I NA NA IG48_Rv0048c-Rv0049 KEEP 52831..53244 52831 53244 + 137 15607191 - Rv0049 - V nonessential hypothetical protein KEEP 53245..53662 53245 53662 I NA NA IG49_Rv0049-Rv0050 KEEP 53663..55699 53663 55547 + 678 57116685 ponA1 Rv0050 COG0744M II.C.3 nonessential bifunctional penicillin-binding protein 1A/1B KEEP 53663..55699 55548 55647 + 678 57116685 ponA1 Rv0050 COG0744M II.C.3 nonessential bifunctional penicillin-binding protein 1A/1B Marin et al 2022 + homoplasy analysis DISCARD 53663..55699 55648 55699 + 678 57116685 ponA1 Rv0050 COG0744M II.C.3 nonessential bifunctional penicillin-binding protein 1A/1B KEEP 55696..57378 55696 57378 + 560 15607193 - Rv0051 COG5650S II.C.5 nonessential transmembrane protein KEEP 57379..57409 57379 57409 I NA NA IG51_Rv0051-Rv0052 KEEP 57410..57973 57410 57973 + 187 15607194 - Rv0052 COG0693R V nonessential hypothetical protein KEEP 57974..58191 57974 58191 I NA NA IG52_Rv0052-Rv0053 KEEP 58192..58482 58192 58482 + 96 15607195 rpsF Rv0053 COG0360J II.A.1 nonessential 30S ribosomal protein S6 KEEP 58483..58585 58483 58585 I NA NA IG53_Rv0053-Rv0054 KEEP 58586..59080 58586 59080 + 164 15607196 ssb Rv0054 COG0629L II.A.5 nonessential single-strand DNA-binding protein KEEP 59081..59121 59081 59121 I NA NA IG54_Rv0054-Rv0055 KEEP 59122..59376 59122 59376 + 84 57116686 rpsR Rv0055 COG0238J II.A.1 nonessential 30S ribosomal protein S18 KEEP 59377..59408 59377 59408 I NA NA IG55_Rv0055-Rv0056 KEEP 59409..59867 59409 59867 + 152 15607198 rplI Rv0056 COG0359J II.A.1 nonessential 50S ribosomal protein L9 KEEP 59868..59895 59868 59895 I NA NA IG56_Rv0056-Rv0057 KEEP 59896..60417 59896 60417 + 173 15607199 - Rv0057 - VI nonessential hypothetical protein KEEP 60396..63020 60396 63020 + 874 15607200 dnaB Rv0058 COG0305L,COG1372L II.A.5 essential replicative DNA helicase KEEP 63021..63199 63021 63199 I NA NA IG58_Rv0058-Rv0059 KEEP 63200..63892 63200 63892 + 230 15607201 - Rv0059 - VI nonessential hypothetical protein KEEP 63893..63908 63893 63908 I NA NA IG59_Rv0059-Rv0060 KEEP 63909..64967 63909 64967 + 352 15607202 - Rv0060 COG2110R V essential hypothetical protein KEEP 64968..64990 64968 64990 I NA NA IG60_Rv0060-Rv0061 KEEP 64991..65416 64991 65416 + 141 15607203 - Rv0061 - VI nonessential hypothetical protein KEEP 65417..65551 65417 65551 I NA NA IG61_Rv0061-Rv0062 KEEP 65552..66694 65552 66694 + 380 57116687 celA1 Rv0062 COG5297G II.B.4 nonessential endo-1,4-beta-glucanase KEEP 66695..66922 66695 66922 I NA NA IG62_Rv0062-Rv0063 KEEP 66923..68362 66923 68362 + 479 15607205 - Rv0063 COG0277C I.B.7 nonessential oxidoreductase KEEP 68363..68619 68363 68619 I NA NA IG63_Rv0063-Rv0064 KEEP 68620..71559 68620 71463 + 979 15607206 - Rv0064 COG1615S II.C.5 nonessential hypothetical protein KEEP 68620..71559 71464 71559 + 979 15607206 - Rv0064 COG1615S II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 71560..71820 71560 71584 I NA NA IG64_Rv0064-Rv0065 Only Marin et al 2022 KEEP 71560..71820 71585 71820 I NA NA IG64_Rv0064-Rv0065 KEEP 71821..72222 71821 72222 + 133 15607207 - Rv0065 COG4113R V nonessential hypothetical protein KEEP 72223..72273 72223 72273 I NA NA IG65_Rv0065-Rv0066c KEEP 72274..74511 72274 74511 - 745 15607208 icd2 Rv0066c COG2838C I.B.3 nonessential isocitrate dehydrogenase [NADP] KEEP 74512..74628 74512 74628 I NA NA IG66_Rv0066c-Rv0067c KEEP 74629..75198 74629 75198 - 189 15607209 - Rv0067c COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 75199..75300 75199 75300 I NA NA IG67_Rv0067c-Rv0068 KEEP 75301..76212 75301 76212 + 303 15607210 - Rv0068 COG1028IQR I.B.7 nonessential short chain dehydrogenase KEEP 76213..76236 76213 76236 I NA NA IG68_Rv0068-Rv0069c KEEP 76237..77622 76237 77622 - 461 15607211 sdaA Rv0069c COG1760E I.C.2 nonessential L-serine dehydratase SdaA KEEP 77619..78896 77619 78896 - 425 15607212 glyA2 Rv0070c COG0112E I.D.3 nonessential serine hydroxymethyltransferase KEEP 78897..79485 78897 79485 I NA NA IG70_Rv0070c-Rv0071 KEEP 79486..80193 79486 79498 + 235 15607213 - Rv0071 COG3344L II.A.5 nonessential maturase KEEP 79486..80193 79499 80193 + 235 15607213 - Rv0071 COG3344L II.A.5 nonessential maturase Only Marin et al 2022 KEEP 80194..80623 80194 80623 I NA NA IG71_Rv0071-Rv0072 Only Marin et al 2022 KEEP 80624..81673 80624 81673 + 349 15607214 - Rv0072 COG0577V II.C.5 nonessential glutamine-transport transmembrane protein ABC transporter Only Marin et al 2022 KEEP 81674..81675 81674 81675 I NA NA IG72_Rv0072-Rv0073 KEEP 81676..82668 81676 82668 + 330 15607215 - Rv0073 COG1136V III.A nonessential glutamine-transport ATP-binding protein ABC transporter Only Marin et al 2022 KEEP 82669..82747 82669 82747 I NA NA IG73_Rv0073-Rv0074 Only Marin et al 2022 KEEP 82748..83983 82748 83035 + 411 15607216 - Rv0074 COG1228Q V nonessential hypothetical protein Only Marin et al 2022 KEEP 82748..83983 83036 83983 + 411 15607216 - Rv0074 COG1228Q V nonessential hypothetical protein KEEP 83984..83995 83984 83995 I NA NA IG74_Rv0074-Rv0075 KEEP 83996..85168 83996 85168 + 390 15607217 - Rv0075 COG1168E IV.H nonessential aminotransferase KEEP 85169..85182 85169 85182 I NA NA IG75_Rv0075-Rv0076c KEEP 85183..85572 85183 85572 - 129 15607218 - Rv0076c - II.C.5 nonessential hypothetical protein KEEP 85573..85635 85573 85635 I NA NA IG76_Rv0076c-Rv0077c KEEP 85636..86466 85636 86466 - 276 15607219 - Rv0077c COG0596R I.B.7 nonessential oxidoreductase KEEP 86467..86527 86467 86527 I NA NA IG77_Rv0077c-Rv0078 KEEP 86528..87133 86528 86777 + 201 15607220 - Rv0078 COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 86528..87133 86778 86782 + 201 15607220 - Rv0078 COG1309K I.J.1 nonessential transcriptional regulatory protein Only Marin et al 2022 KEEP 86528..87133 86783 87133 + 201 15607220 - Rv0078 COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 87134..87207 87134 87207 I NA NA IG78_Rv0078-Rv0078A KEEP 87208..87801 87208 87801 - 197 57116688 - Rv0078A - VI nonessential hypothetical protein KEEP 87802..88203 87802 88203 I NA NA IG79_Rv0078A-Rv0079 KEEP 88204..89025 88204 89025 + 273 15607221 - Rv0079 COG1544J VI nonessential hypothetical protein KEEP 89022..89480 89022 89480 + 152 15607222 - Rv0080 - V nonessential hypothetical protein KEEP 89481..89574 89481 89574 I NA NA IG81_Rv0080-Rv0081 KEEP 89575..89919 89575 89919 + 114 15607223 - Rv0081 COG0640K I.J.1 nonessential transcriptional regulatory protein KEEP 89920..89923 89920 89923 I NA NA IG82_Rv0081-Rv0082 KEEP 89924..90403 89924 90403 + 159 15607224 - Rv0082 COG3260C I.B.7 nonessential oxidoreductase KEEP 90400..92322 90400 92322 + 640 15607225 - Rv0083 COG0651CP I.B.7 nonessential oxidoreductase KEEP 92323..92327 92323 92327 I NA NA IG84_Rv0083-Rv0084 KEEP 92328..93278 92328 93278 + 316 15607226 hycD Rv0084 COG0650C I.B.5a nonessential formate hydrogenlyase HYCD KEEP 93279..93288 93279 93288 I NA NA IG85_Rv0084-Rv0085 KEEP 93289..93951 93289 93951 + 220 15607227 hycP Rv0085 COG4237C I.B.5a essential hydrogenase HycP KEEP 93951..95417 93951 95417 + 488 15607228 hycQ Rv0086 COG0651CP I.B.5a essential hydrogenase HycQ KEEP 95414..96892 95414 96892 + 492 15607229 hycE Rv0087 COG3261C,COG3262C I.B.5b nonessential formate hydrogenase HycE KEEP 96893..96926 96893 96926 I NA NA IG88_Rv0087-Rv0088 KEEP 96927..97601 96927 97601 + 224 15607230 - Rv0088 COG0030J VI nonessential hypothetical protein KEEP 97602..97757 97602 97757 I NA NA IG89_Rv0088-Rv0089 KEEP 97758..98351 97758 98351 + 197 15607231 - Rv0089 COG0500QR I.G.1 nonessential methyltransferase/methylase KEEP 98352..98479 98352 98479 I NA NA IG90_Rv0089-Rv0090 KEEP 98480..99250 98480 99250 + 256 15607232 - Rv0090 COG0601EP,COG3305S II.C.5 nonessential hypothetical protein KEEP 99251..99683 99251 99683 I NA NA IG91_Rv0090-Rv0091 KEEP 99684..100451 99684 100451 + 255 15607233 mtn Rv0091 COG0775F IV.I nonessential bifunctional 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase KEEP 100452..100582 100452 100582 I NA NA IG92_Rv0091-Rv0092 KEEP 100583..102868 100583 102868 + 761 15607234 ctpA Rv0092 COG2217P III.A.2 nonessential cation transporter P-type ATPase A KEEP 102815..103663 102815 103663 - 282 15607235 - Rv0093c COG5660S II.C.4 nonessential hypothetical protein KEEP 103664..103709 103664 103701 I NA NA IG94_Rv0093c-Rv0094c KEEP 103664..103709 103702 103709 I NA NA IG94_Rv0093c-Rv0094c Annotation + Marin et al 2022 DISCARD 103710..104663 103710 104663 - 317 15607236 - Rv0094c - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 104664..104804 104664 104804 I NA NA IG95_Rv0094c-Rv0095c repeat Annotation + Marin et al 2022 DISCARD 104805..105215 104805 104811 - 136 15607237 - Rv0095c - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 104805..105215 104812 104812 - 136 15607237 - Rv0095c - V repeat13E12 nonessential hypothetical protein KEEP 104805..105215 104813 105137 - 136 15607237 - Rv0095c - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 104805..105215 105138 105215 - 136 15607237 - Rv0095c - V repeat13E12 nonessential hypothetical protein KEEP 105216..105323 105216 105323 I NA NA IG96_Rv0095c-Rv0096 repeat KEEP 105324..106715 105324 106715 + 463 57116689 PPE1 Rv0096 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 106716..106733 106716 106733 I NA NA IG97_Rv0096-Rv0097 KEEP 106734..107603 106734 107603 + 289 15607239 - Rv0097 COG2175Q I.B.7 nonessential oxidoreductase KEEP 107600..108151 107600 108151 + 183 15607240 - Rv0098 - V essential hypothetical protein KEEP 108152..108155 108152 108155 I NA NA IG99_Rv0098-Rv0099 KEEP 108156..109778 108156 109778 + 540 15607241 fadD10 Rv0099 COG0318IQ I.A.3 essential acyl-CoA synthetase KEEP 109779..109782 109779 109782 I NA NA IG100_Rv0099-Rv0100 KEEP 109783..110019 109783 110019 + 78 15607242 - Rv0100 COG3433Q V essential hypothetical protein KEEP 110001..117539 110001 117539 + 2512 15607243 nrp Rv0101 COG1020Q,COG3320Q I.I essential peptide synthetase KEEP 117540..117713 117540 117713 I NA NA IG102_Rv0101-Rv0102 KEEP 117714..119699 117714 119699 + 661 15607244 - Rv0102 COG3336S II.C.5 essential integral membrane protein KEEP 119700..119914 119700 119914 I NA NA IG103_Rv0102-Rv0103c KEEP 119915..122173 119915 122173 - 752 15607245 ctpB Rv0103c COG2217P III.A.2 nonessential cation-transporter P-type ATPase B KEEP 122174..122316 122174 122316 I NA NA IG104_Rv0103c-Rv0104 KEEP 122317..123831 122317 123831 + 504 15607246 - Rv0104 COG0664T V nonessential hypothetical protein KEEP 123832..123979 123832 123979 I NA NA IG105_Rv0104-Rv0105c KEEP 123980..124264 123980 124264 - 94 57116690 rpmB Rv0105c COG0227J II.A.1 nonessential 50S ribosomal protein L28 KEEP 124265..124373 124265 124373 I NA NA IG106_Rv0105c-Rv0106 KEEP 124374..125570 124374 125570 + 398 15607248 - Rv0106 COG0523R V nonessential hypothetical protein KEEP 125571..125642 125571 125642 I NA NA IG107_Rv0106-Rv0107c KEEP 125643..130541 125643 130541 - 1632 15607249 ctpI Rv0107c COG0474P III.A.2 nonessential cation-transporter ATPase I KEEP 130542..130894 130542 130894 I NA NA IG108_Rv0107c-Rv0108c KEEP 130895..131104 130895 131104 - 69 15607250 - Rv0108c - VI nonessential hypothetical protein KEEP 131105..131381 131105 131381 I NA NA IG109_Rv0108c-Rv0109 KEEP 131382..132872 131382 131784 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 131382..132872 131785 131844 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 131382..132872 131845 131927 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 131382..132872 131928 131982 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 131382..132872 131983 131991 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 131382..132872 131992 131993 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 131382..132872 131994 132076 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 131382..132872 132077 132079 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 131382..132872 132080 132158 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 131382..132872 132159 132189 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 131382..132872 132190 132517 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 131382..132872 132518 132684 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 131382..132872 132685 132872 + 496 57116691 PE_PGRS1 Rv0109 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 132873..133019 132873 133019 I NA NA IG110_Rv0109-Rv0110 KEEP 133020..133769 133020 133769 + 249 15607252 - Rv0110 COG0705R II.C.5 nonessential integral membrane protein KEEP 133770..133949 133770 133949 I NA NA IG111_Rv0110-Rv0111 KEEP 133950..136007 133950 136007 + 685 15607253 - Rv0111 COG1835I II.C.5 nonessential transmembrane acyltransferase KEEP 136008..136288 136008 136288 I NA NA IG112_Rv0111-Rv0112 KEEP 136289..137245 136289 137245 + 318 15607254 gca Rv0112 COG0451MG II.C.2 essential GDP-mannose 4,6-dehydratase KEEP 137246..137318 137246 137318 I NA NA IG113_Rv0112-Rv0113 KEEP 137319..137909 137319 137909 + 196 15607255 gmhA Rv0113 COG0279G II.C.2 nonessential sedoheptulose-7-phosphate isomerase KEEP 137910..137940 137910 137940 I NA NA IG114_Rv0113-Rv0114 KEEP 137941..138513 137941 138513 + 190 15607256 gmhB Rv0114 COG0241E I.D.5 nonessential D-alpha,beta-D-heptose-1,7-biphosphate phosphatase KEEP 138513..139673 138513 139673 + 386 15607257 hddA Rv0115 COG2605R VII nonessential D-alpha-D-heptose-7-phosphate kinase KEEP 139674..140266 139674 140266 I NA NA IG116_Rv0115-Rv0116c KEEP 140267..141022 140267 141022 - 251 15607258 - Rv0116c COG1376S II.C.5 nonessential hypothetical protein KEEP 141023..141199 141023 141199 I NA NA IG117_Rv0116c-Rv0117 KEEP 141200..142144 141200 142144 + 314 15607259 oxyS Rv0117 COG0583K I.J.1 nonessential oxidative stress response regulatory protein OXYS KEEP 142128..143876 142128 143876 - 582 15607260 oxcA Rv0118c COG0028EH I.A.1 essential putative oxalyl-CoA decarboxylase KEEP 143877..144048 143877 144048 I NA NA IG119_Rv0118c-Rv0119 KEEP 144049..145626 144049 145626 + 525 15607261 fadD7 Rv0119 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 145627..147771 145627 147771 - 714 15607262 fusA2 Rv0120c COG0480J II.A.6 nonessential elongation factor G KEEP 147772..147907 147772 147907 I NA NA IG121_Rv0120c-Rv0121c KEEP 147908..148342 147908 148342 - 144 15607263 - Rv0121c COG3576R V nonessential hypothetical protein KEEP 148343..148490 148343 148490 I NA NA IG122_Rv0121c-Rv0122 KEEP 148491..148859 148491 148859 + 122 15607264 - Rv0122 - VI nonessential hypothetical protein KEEP 148856..149224 148856 149224 + 122 15607265 - Rv0123 - VI nonessential hypothetical protein KEEP 149225..149532 149225 149498 I NA NA IG124_Rv0123-Rv0124 KEEP 149225..149532 149499 149526 I NA NA IG124_Rv0123-Rv0124 Annotation + Marin et al 2022 DISCARD 149225..149532 149527 149532 I NA NA IG124_Rv0123-Rv0124 KEEP 149533..150996 149533 149633 + 487 57116692 PE_PGRS2 Rv0124 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 149533..150996 149634 149760 + 487 57116692 PE_PGRS2 Rv0124 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 149533..150996 149761 149824 + 487 57116692 PE_PGRS2 Rv0124 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 149533..150996 149825 150890 + 487 57116692 PE_PGRS2 Rv0124 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 149533..150996 150891 150996 + 487 57116692 PE_PGRS2 Rv0124 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 150997..151147 150997 151147 I NA NA IG125_Rv0124-Rv0125 KEEP 151148..152215 151148 152215 + 355 15607267 pepA Rv0125 COG0265O II.B.3 nonessential serine protease PepA KEEP 152216..152323 152216 152323 I NA NA IG126_Rv0125-Rv0126 KEEP 152324..154129 152324 154108 + 601 15607268 treS Rv0126 COG0366G II.A.8 nonessential trehalose synthase TRES KEEP 152324..154129 154109 154129 + 601 15607268 treS Rv0126 COG0366G II.A.8 nonessential trehalose synthase TRES Only Marin et al 2022 KEEP 154130..154231 154130 154231 I NA NA IG127_Rv0126-Rv0127 Only Marin et al 2022 KEEP 154232..155599 154232 154245 + 455 15607269 - Rv0127 COG3281G V essential hypothetical protein Only Marin et al 2022 KEEP 154232..155599 154246 155599 + 455 15607269 - Rv0127 COG3281G V essential hypothetical protein KEEP 155600..155666 155600 155666 I NA NA IG128_Rv0127-Rv0128 KEEP 155667..156446 155667 156446 + 259 15607270 - Rv0128 COG3619S II.C.5 nonessential transmembrane protein KEEP 156447..156577 156447 156577 I NA NA IG129_Rv0128-Rv0129c KEEP 156578..157600 156578 157277 - 340 57116693 fbpC Rv0129c COG0627R I.H.3 DR-inh nonessential secreted antigen 85-C FBPC (85C) (antigen 85 complex C) (AG58C) (Mycolyl transferase 85C) (fibronectin-binding protein C) KEEP 156578..157600 157278 157331 - 340 57116693 fbpC Rv0129c COG0627R I.H.3 DR-inh nonessential secreted antigen 85-C FBPC (85C) (antigen 85 complex C) (AG58C) (Mycolyl transferase 85C) (fibronectin-binding protein C) Only Marin et al 2022 KEEP 156578..157600 157332 157381 - 340 57116693 fbpC Rv0129c COG0627R I.H.3 DR-inh nonessential secreted antigen 85-C FBPC (85C) (antigen 85 complex C) (AG58C) (Mycolyl transferase 85C) (fibronectin-binding protein C) KEEP 156578..157600 157382 157433 - 340 57116693 fbpC Rv0129c COG0627R I.H.3 DR-inh nonessential secreted antigen 85-C FBPC (85C) (antigen 85 complex C) (AG58C) (Mycolyl transferase 85C) (fibronectin-binding protein C) Only Marin et al 2022 KEEP 156578..157600 157434 157600 - 340 57116693 fbpC Rv0129c COG0627R I.H.3 DR-inh nonessential secreted antigen 85-C FBPC (85C) (antigen 85 complex C) (AG58C) (Mycolyl transferase 85C) (fibronectin-binding protein C) KEEP 157601..157846 157601 157846 I NA NA IG130_Rv0129c-Rv0130 DR-inh KEEP 157847..158302 157847 158302 + 151 15607272 - Rv0130 COG2030I V nonessential hypothetical protein KEEP 158303..158314 158303 158314 I NA NA IG131_Rv0130-Rv0131c KEEP 158315..159658 158315 159658 - 447 15607273 fadE1 Rv0131c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE1 KEEP 159659..159699 159659 159699 I NA NA IG132_Rv0131c-Rv0132c KEEP 159700..160782 159700 160782 - 360 15607274 fgd2 Rv0132c COG2141C I.B.7 nonessential putative f420-dependent glucose-6-phosphate dehydrogenase Fgd2 KEEP 160783..160868 160783 160868 I NA NA IG133_Rv0132c-Rv0133 KEEP 160869..161474 160869 161474 + 201 15607275 - Rv0133 COG0454KR IV.D nonessential acetyltransferase KEEP 161475..161770 161475 161525 I NA NA IG134_Rv0133-Rv0134 KEEP 161475..161770 161526 161577 I NA NA IG134_Rv0133-Rv0134 Only Marin et al 2022 KEEP 161475..161770 161578 161770 I NA NA IG134_Rv0133-Rv0134 KEEP 161771..162673 161771 162673 + 300 15607276 ephF Rv0134 COG0596R III.F nonessential epoxide hydrolase EphF KEEP 162644..163249 162644 163249 - 201 15607277 - Rv0135c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 163250..163365 163250 163365 I NA NA IG136_Rv0135c-Rv0136 KEEP 163366..164691 163366 164691 + 441 15607278 cyp138 Rv0136 COG2124Q IV.F nonessential cytochrome P450 138 KEEP 164692..164711 164692 164711 I NA NA IG137_Rv0136-Rv0137c KEEP 164712..165260 164712 165260 - 182 15607279 msrA Rv0137c COG0225O I.B.7 nonessential methionine sulfoxide reductase A KEEP 165261..165322 165261 165322 I NA NA IG138_Rv0137c-Rv0138 KEEP 165323..165826 165323 165826 + 167 15607280 - Rv0138 - V nonessential hypothetical protein KEEP 165827..166849 165827 166849 + 340 15607281 - Rv0139 COG0451MG I.B.7 nonessential oxidoreductase KEEP 166850..166909 166850 166909 I NA NA IG140_Rv0139-Rv0140 KEEP 166910..167290 166910 167290 + 126 15607282 - Rv0140 COG2343S V nonessential hypothetical protein KEEP 167271..167681 167271 167681 - 136 15607283 - Rv0141c COG3631R VI nonessential hypothetical protein KEEP 167682..167710 167682 167710 I NA NA IG142_Rv0141c-Rv0142 KEEP 167711..168637 167711 168637 + 308 15607284 - Rv0142 COG0122L V nonessential hypothetical protein KEEP 168638..168703 168638 168703 I NA NA IG143_Rv0142-Rv0143c KEEP 168704..170182 168704 170182 - 492 15607285 - Rv0143c COG0038P III.A.4 nonessential transmembrane protein KEEP 170183..170283 170183 170283 I NA NA IG144_Rv0143c-Rv0144 KEEP 170284..171126 170284 171126 + 280 15607286 - Rv0144 COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 171127..171214 171127 171214 I NA NA IG145_Rv0144-Rv0145 KEEP 171215..172168 171215 171455 + 317 15607287 - Rv0145 COG3315Q V nonessential hypothetical protein KEEP 171215..172168 171456 171457 + 317 15607287 - Rv0145 COG3315Q V nonessential hypothetical protein Only Marin et al 2022 KEEP 171215..172168 171458 171777 + 317 15607287 - Rv0145 COG3315Q V nonessential hypothetical protein KEEP 171215..172168 171778 171779 + 317 15607287 - Rv0145 COG3315Q V nonessential hypothetical protein Only Marin et al 2022 KEEP 171215..172168 171780 172168 + 317 15607287 - Rv0145 COG3315Q V nonessential hypothetical protein KEEP 172169..172210 172169 172210 I NA NA IG146_Rv0145-Rv0146 KEEP 172211..173143 172211 173143 + 310 15607288 - Rv0146 COG3315Q V nonessential hypothetical protein KEEP 173144..173237 173144 173237 I NA NA IG147_Rv0146-Rv0147 KEEP 173238..174758 173238 174758 + 506 15607289 - Rv0147 COG1012C VI nonessential aldehyde dehydrogenase KEEP 174759..174832 174759 174832 I NA NA IG148_Rv0147-Rv0148 KEEP 174833..175693 174833 175693 + 286 15607290 - Rv0148 COG1028IQR VI nonessential short-chain type dehydrogenase/reductase KEEP 175694..175699 175694 175699 I NA NA IG149_Rv0148-Rv0149 KEEP 175700..176668 175700 176668 + 322 15607291 - Rv0149 COG0604CR IV.F nonessential quinone oxidoreductase KEEP 176665..176952 176665 176952 - 95 15607292 - Rv0150c - V nonessential hypothetical protein KEEP 176953..177542 176953 177093 I NA NA IG151_Rv0150c-Rv0151c KEEP 176953..177542 177094 177180 I NA NA IG151_Rv0150c-Rv0151c Annotation + Marin et al 2022 DISCARD 176953..177542 177181 177224 I NA NA IG151_Rv0150c-Rv0151c KEEP 176953..177542 177225 177322 I NA NA IG151_Rv0150c-Rv0151c Annotation + Marin et al 2022 DISCARD 176953..177542 177323 177336 I NA NA IG151_Rv0150c-Rv0151c KEEP 176953..177542 177337 177408 I NA NA IG151_Rv0150c-Rv0151c Annotation + Marin et al 2022 DISCARD 176953..177542 177409 177542 I NA NA IG151_Rv0150c-Rv0151c KEEP 177543..179309 177543 179309 - 588 57116694 PE1 Rv0151c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 179310..179318 179310 179318 I NA NA IG152_Rv0151c-Rv0152c repeat KEEP 179319..180896 179319 180896 - 525 57116695 PE2 Rv0152c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 180897..181154 180897 181154 I NA NA IG153_Rv0152c-Rv0153c KEEP 181155..181985 181155 181985 - 276 15607295 ptbB Rv0153c COG2365T I.J.3 nonessential phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) KEEP 181987..183198 181987 183198 - 403 15607296 fadE2 Rv0154c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE2 KEEP 183199..183621 183199 183621 I NA NA IG155_Rv0154c-Rv0155 KEEP 183622..184722 183622 184722 + 366 15607297 pntAa Rv0155 COG3288C I.C.1 nonessential NAD(P) transhydrogenase subunit alpha KEEP 184723..185055 184723 185055 + 110 15607298 pntAb Rv0156 COG3288C I.C.1 nonessential NAD(P) transhydrogenase subunit alpha KEEP 185052..186479 185052 186479 + 475 15607299 pntB Rv0157 COG1282C I.C.1 nonessential NAD(P) transhydrogenase subunit beta KEEP 186480..186784 186480 186784 I NA NA IG158_Rv0157-Rv0158 KEEP 186785..187429 186785 187429 + 214 15607300 - Rv0158 COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 187430..187432 187430 187432 I NA NA IG159_Rv0158-Rv0159c KEEP 187433..188839 187433 188839 - 468 57116696 PE3 Rv0159c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 188840..188930 188840 188930 I NA NA IG160_Rv0159c-Rv0160c repeat KEEP 188931..190439 188931 190439 - 502 57116697 PE4 Rv0160c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 190440..190606 190440 190606 I NA NA IG161_Rv0160c-Rv0161 KEEP 190607..191956 190607 191956 + 449 15607303 - Rv0161 COG0277C I.B.7 nonessential oxidoreductase KEEP 191957..191983 191957 191983 I NA NA IG162_Rv0161-Rv0162c KEEP 191984..193135 191984 192335 - 383 57116698 adhE1 Rv0162c COG1062C I.B.7 nonessential zinc-type alcohol dehydrogenase E subunit KEEP 191984..193135 192336 192398 - 383 57116698 adhE1 Rv0162c COG1062C I.B.7 nonessential zinc-type alcohol dehydrogenase E subunit Only Marin et al 2022 KEEP 191984..193135 192399 193135 - 383 57116698 adhE1 Rv0162c COG1062C I.B.7 nonessential zinc-type alcohol dehydrogenase E subunit KEEP 193117..193572 193117 193572 + 151 15607305 - Rv0163 COG0824R V nonessential hypothetical protein KEEP 193573..193625 193573 193625 I NA NA IG164_Rv0163-Rv0164 KEEP 193626..194111 193626 194111 + 161 57116699 TB18.5 Rv0164 COG2867I V nonessential hypothetical protein KEEP 194112..194143 194112 194143 I NA NA IG165_Rv0164-Rv0165c KEEP 194144..194938 194144 194938 - 264 57116700 - Rv0165c COG1802K I.J.1 nonessential GntR family transcriptional regulator KEEP 194939..194992 194939 194992 I NA NA IG166_Rv0165c-Rv0166 KEEP 194993..196657 194993 196657 + 554 15607307 fadD5 Rv0166 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 196658..196860 196658 196860 I NA NA IG167_Rv0166-Rv0167 KEEP 196861..197658 196861 197076 + 265 15607308 yrbE1A Rv0167 COG0767Q IV.A nonessential integral membrane protein YRBE1A KEEP 196861..197658 197077 197130 + 265 15607308 yrbE1A Rv0167 COG0767Q IV.A nonessential integral membrane protein YRBE1A Only Marin et al 2022 KEEP 196861..197658 197131 197190 + 265 15607308 yrbE1A Rv0167 COG0767Q IV.A nonessential integral membrane protein YRBE1A KEEP 196861..197658 197191 197311 + 265 15607308 yrbE1A Rv0167 COG0767Q IV.A nonessential integral membrane protein YRBE1A Only Marin et al 2022 KEEP 196861..197658 197312 197658 + 265 15607308 yrbE1A Rv0167 COG0767Q IV.A nonessential integral membrane protein YRBE1A KEEP 197660..198529 197660 197836 + 289 15607309 yrbE1B Rv0168 COG0767Q IV.A nonessential integral membrane protein YRBE1B KEEP 197660..198529 197837 198006 + 289 15607309 yrbE1B Rv0168 COG0767Q IV.A nonessential integral membrane protein YRBE1B Only Marin et al 2022 KEEP 197660..198529 198007 198088 + 289 15607309 yrbE1B Rv0168 COG0767Q IV.A nonessential integral membrane protein YRBE1B KEEP 197660..198529 198089 198170 + 289 15607309 yrbE1B Rv0168 COG0767Q IV.A nonessential integral membrane protein YRBE1B Only Marin et al 2022 KEEP 197660..198529 198171 198476 + 289 15607309 yrbE1B Rv0168 COG0767Q IV.A nonessential integral membrane protein YRBE1B KEEP 197660..198529 198477 198529 + 289 15607309 yrbE1B Rv0168 COG0767Q IV.A nonessential integral membrane protein YRBE1B Only Marin et al 2022 KEEP 198530..198533 198530 198533 I NA NA IG169_Rv0168-Rv0169 Only Marin et al 2022 KEEP 198534..199898 198534 198537 + 454 57116701 mce1A Rv0169 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1A Only Marin et al 2022 KEEP 198534..199898 198538 198935 + 454 57116701 mce1A Rv0169 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1A KEEP 198534..199898 198936 199041 + 454 57116701 mce1A Rv0169 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1A Only Marin et al 2022 KEEP 198534..199898 199042 199749 + 454 57116701 mce1A Rv0169 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1A KEEP 198534..199898 199750 199832 + 454 57116701 mce1A Rv0169 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1A Only Marin et al 2022 KEEP 198534..199898 199833 199898 + 454 57116701 mce1A Rv0169 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1A KEEP 199895..200935 199895 200935 + 346 15607311 mce1B Rv0170 COG1463Q IV.A essential MCE-family protein MCE1B KEEP 200932..202479 200932 201951 + 515 15607312 mce1C Rv0171 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1C KEEP 200932..202479 201952 202014 + 515 15607312 mce1C Rv0171 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1C Only Marin et al 2022 KEEP 200932..202479 202015 202479 + 515 15607312 mce1C Rv0171 COG0840NT,COG1463Q IV.A essential MCE-family protein MCE1C KEEP 202476..204068 202476 204068 + 530 15607313 mce1D Rv0172 COG1463Q IV.A nonessential MCE-family protein MCE1D KEEP 204065..205237 204065 205237 + 390 15607314 lprK Rv0173 COG1463Q II.C.1 essential MCE-family lipoprotein LprK KEEP 205231..206778 205231 206493 + 515 15607315 mce1F Rv0174 COG1463Q IV.A nonessential MCE-family protein MCE1F KEEP 205231..206778 206494 206519 + 515 15607315 mce1F Rv0174 COG1463Q IV.A nonessential MCE-family protein MCE1F Only Marin et al 2022 KEEP 205231..206778 206520 206778 + 515 15607315 mce1F Rv0174 COG1463Q IV.A nonessential MCE-family protein MCE1F KEEP 206779..206813 206779 206813 I NA NA IG175_Rv0174-Rv0175 KEEP 206814..207455 206814 207455 + 213 15607316 - Rv0175 - II.C.5 essential mce associated membrane protein KEEP 207452..208420 207452 208420 + 322 15607317 - Rv0176 COG1714S II.C.5 essential mce associated transmembrane protein KEEP 208417..208971 208417 208971 + 184 15607318 - Rv0177 - VI nonessential MCE associated protein KEEP 208938..209672 208938 209672 + 244 15607319 - Rv0178 - II.C.5 nonessential mce associated membrane protein KEEP 209673..209702 209673 209702 I NA NA IG179_Rv0178-Rv0179c KEEP 209703..210812 209703 210812 - 369 15607320 lprO Rv0179c - II.C.1 nonessential lipoprotein LprO KEEP 210813..210891 210813 210891 I NA NA IG180_Rv0179c-Rv0180c KEEP 210892..212250 210892 212250 - 452 15607321 - Rv0180c COG1511S II.C.5 nonessential transmembrane protein KEEP 212251..212276 212251 212276 I NA NA IG181_Rv0180c-Rv0181c KEEP 212277..213011 212277 213011 - 244 15607322 - Rv0181c COG1741R V nonessential hypothetical protein KEEP 213012..213027 213012 213027 I NA NA IG182_Rv0181c-Rv0182c KEEP 213028..214140 213028 214140 - 370 15607323 sigG Rv0182c COG1595K II.A.7 nonessential RNA polymerase factor sigma-70 KEEP 214088..214927 214088 214927 + 279 57116702 - Rv0183 COG2267I VI nonessential lysophospholipase KEEP 214928..214968 214928 214968 I NA NA IG184_Rv0183-Rv0184 KEEP 214969..215718 214969 215718 + 249 15607325 - Rv0184 - V nonessential hypothetical protein KEEP 215715..216224 215715 216224 + 169 15607326 - Rv0185 - V nonessential hypothetical protein KEEP 216225..216268 216225 216268 I NA NA IG186_Rv0185-Rv0186 KEEP 216269..218344 216269 218344 + 691 15607327 bglS Rv0186 COG1472G I.A.1 nonessential beta-glucosidase KEEP 218345..218704 218345 218704 I NA NA IG187_Rv0186-Rv0187 KEEP 218705..219367 218705 219367 + 220 15607328 - Rv0187 COG4122R IV.H nonessential O-methyltransferase KEEP 219368..219485 219368 219485 I NA NA IG188_Rv0187-Rv0188 KEEP 219486..219917 219486 219917 + 143 15607329 - Rv0188 - II.C.5 nonessential transmembrane protein KEEP 219918..219995 219918 219995 I NA NA IG189_Rv0188-Rv0189c KEEP 219996..221723 219996 221723 - 575 15607330 ilvD Rv0189c COG0129EG I.D.7 essential dihydroxy-acid dehydratase KEEP 221724..221870 221724 221870 I NA NA IG190_Rv0189c-Rv0190 KEEP 221871..222161 221871 222161 + 96 15607331 - Rv0190 COG1937S V nonessential hypothetical protein KEEP 222162..222288 222162 222288 I NA NA IG191_Rv0190-Rv0191 KEEP 222289..223530 222289 223530 + 413 15607332 - Rv0191 COG2814G II.C.5 nonessential integral membrane protein KEEP 223531..223563 223531 223563 I NA NA IG192_Rv0191-Rv0192 KEEP 223564..224664 223564 224664 + 366 15607333 - Rv0192 COG1376S V nonessential hypothetical protein KEEP 223607..223909 223607 223909 + 100 57116703 - Rv0192A - VI nonessential hypothetical protein KEEP 223910..224723 223910 224723 I NA NA IG194_Rv0192A-Rv0193c KEEP 224724..226571 224724 226571 - 615 15607334 - Rv0193c - VI nonessential hypothetical protein KEEP 226572..226877 226572 226877 I NA NA IG195_Rv0193c-Rv0194 KEEP 226878..230462 226878 230462 + 1194 15607335 - Rv0194 COG1132V II.C.5 nonessential drugs-transport transmembrane ATP-binding protein ABC transporter KEEP 230463..230898 230463 230898 I NA NA IG196_Rv0194-Rv0195 KEEP 230899..231534 230899 231534 + 211 15607336 - Rv0195 COG2197TK I.J.1 nonessential two component transcriptional regulatory protein KEEP 231535..231646 231535 231646 I NA NA IG197_Rv0195-Rv0196 KEEP 231647..232231 231647 232231 + 194 15607337 - Rv0196 COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 232231..234519 232231 234445 + 762 15607338 - Rv0197 COG0243C I.B.7 nonessential oxidoreductase KEEP 232231..234519 234446 234492 + 762 15607338 - Rv0197 COG0243C I.B.7 nonessential oxidoreductase Only Marin et al 2022 KEEP 232231..234519 234493 234519 + 762 15607338 - Rv0197 COG0243C I.B.7 nonessential oxidoreductase KEEP 234516..236507 234516 236507 - 663 15607339 - Rv0198c COG3590O II.B.3 nonessential zinc metalloprotease KEEP 236508..236549 236508 236549 I NA NA IG200_Rv0198c-Rv0199 KEEP 236550..237209 236550 237209 + 219 15607340 - Rv0199 - II.C.4 essential hypothetical protein KEEP 237206..237895 237206 237895 + 229 15607341 - Rv0200 - II.C.5 nonessential transmembrane protein KEEP 237892..238395 237892 238395 - 167 15607342 - Rv0201c COG1476K V nonessential hypothetical protein KEEP 238392..241292 238392 241292 - 966 15607343 mmpL11 Rv0202c COG2409R II.C.4 nonessential transmembrane transport protein MmpL11 KEEP 241293..241513 241293 241513 I NA NA IG204_Rv0202c-Rv0203 KEEP 241514..241924 241514 241924 + 136 15607344 - Rv0203 - VI nonessential hypothetical protein KEEP 241925..241975 241925 241975 I NA NA IG205_Rv0203-Rv0204c KEEP 241976..243214 241976 243214 - 412 15607345 - Rv0204c COG0392S II.C.5 essential transmembrane protein KEEP 243215..243383 243215 243383 I NA NA IG206_Rv0204c-Rv0205 KEEP 243384..244487 243384 244487 + 367 15607346 - Rv0205 COG0628R II.C.5 essential transmembrane protein KEEP 244484..247318 244484 247318 - 944 15607347 mmpL3 Rv0206c COG2409R II.C.4 nonessential transmembrane transport protein MmpL3 KEEP 247319..247383 247319 247383 I NA NA IG208_Rv0206c-Rv0207c KEEP 247384..248112 247384 248112 - 242 15607348 - Rv0207c COG1432S V nonessential hypothetical protein KEEP 248113..248114 248113 248114 I NA NA IG209_Rv0207c-Rv0208c KEEP 248115..248906 248115 248906 - 263 15607349 trmB Rv0208c COG0220R VI essential tRNA (guanine-N(7))-methyltransferase KEEP 248907..249037 248907 249037 I NA NA IG210_Rv0208c-Rv0209 KEEP 249038..250123 249038 250123 + 361 15607350 - Rv0209 - VI nonessential hypothetical protein KEEP 250120..251598 250120 251598 + 492 15607351 - Rv0210 - VI nonessential hypothetical protein KEEP 251599..251781 251599 251781 I NA NA IG212_Rv0210-Rv0211 KEEP 251782..253602 251782 253597 + 606 15607352 pckA Rv0211 COG1274C I.C.2 nonessential phosphoenolpyruvate carboxykinase KEEP 251782..253602 253598 253602 + 606 15607352 pckA Rv0211 COG1274C I.C.2 nonessential phosphoenolpyruvate carboxykinase Only Marin et al 2022 KEEP 253603..253668 253603 253666 I NA NA IG213_Rv0211-Rv0212c Only Marin et al 2022 KEEP 253603..253668 253667 253668 I NA NA IG213_Rv0211-Rv0212c KEEP 253669..254640 253669 254640 - 323 15607353 nadR Rv0212c COG1056H,COG3172H I.J.1 nonessential transcriptional regulatory protein NadR KEEP 254637..255950 254637 255950 - 437 15607354 - Rv0213c COG1032C IV.H nonessential methyltransferase (methylase) KEEP 255951..256063 255951 256063 I NA NA IG215_Rv0213c-Rv0214 KEEP 256064..257677 256064 257677 + 537 15607355 fadD4 Rv0214 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 257678..257782 257678 257782 I NA NA IG216_Rv0214-Rv0215c KEEP 257783..258856 257783 258856 - 357 15607356 fadE3 Rv0215c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE3 KEEP 258857..258912 258857 258912 I NA NA IG217_Rv0215c-Rv0216 KEEP 258913..259926 258913 259926 + 337 15607357 - Rv0216 COG2030I V essential hypothetical protein KEEP 259923..260831 259923 260831 - 302 15607358 lipW Rv0217c COG0657I II.B.5 nonessential esterase LipW KEEP 260832..260923 260832 260923 I NA NA IG219_Rv0217c-Rv0218 KEEP 260924..262252 260924 262252 + 442 15607359 - Rv0218 COG2041R II.C.5 essential transmembrane protein KEEP 262254..262802 262254 262802 + 182 15607360 - Rv0219 - II.C.5 nonessential transmembrane protein KEEP 262803..262811 262803 262811 I NA NA IG221_Rv0219-Rv0220 KEEP 262812..264023 262812 264023 + 403 15607361 lipC Rv0220 COG0657I II.B.5 nonessential esterase LipC KEEP 264024..264066 264024 264066 I NA NA IG222_Rv0220-Rv0221 KEEP 264067..265476 264067 265476 + 469 15607362 - Rv0221 COG1020Q V nonessential hypothetical protein KEEP 265477..265506 265477 265506 I NA NA IG223_Rv0221-Rv0222 KEEP 265507..266295 265507 266295 + 262 15607363 echA1 Rv0222 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 266296..266300 266296 266300 I NA NA IG224_Rv0222-Rv0223c KEEP 266301..267764 266301 267756 - 487 15607364 - Rv0223c COG1012C I.B.7 nonessential aldehyde dehydrogenase KEEP 266301..267764 267757 267764 - 487 15607364 - Rv0223c COG1012C I.B.7 nonessential aldehyde dehydrogenase Only Marin et al 2022 KEEP 267765..267862 267765 267812 I NA NA IG225_Rv0223c-Rv0224c Only Marin et al 2022 KEEP 267765..267862 267813 267862 I NA NA IG225_Rv0223c-Rv0224c KEEP 267863..268627 267863 268627 - 254 15607365 - Rv0224c COG0500QR IV.H essential methyltransferase (methylase) KEEP 268628..268662 268628 268662 I NA NA IG226_Rv0224c-Rv0225 KEEP 268663..269817 268663 269817 + 384 15607366 - Rv0225 COG0438M VII nonessential hypothetical protein KEEP 269818..269833 269818 269833 I NA NA IG227_Rv0225-Rv0226c KEEP 269834..271564 269834 271564 - 576 15607367 - Rv0226c - II.C.5 essential transmembrane protein KEEP 271565..271573 271565 271573 I NA NA IG228_Rv0226c-Rv0227c KEEP 271574..272839 271574 272839 - 421 15607368 - Rv0227c - II.C.4 essential hypothetical protein KEEP 272840..273054 272840 272847 I NA NA IG229_Rv0227c-Rv0228 KEEP 272840..273054 272848 272957 I NA NA IG229_Rv0227c-Rv0228 Only Marin et al 2022 KEEP 272840..273054 272958 273054 I NA NA IG229_Rv0227c-Rv0228 KEEP 273055..274278 273055 274278 + 407 15607369 - Rv0228 COG1835I II.C.5 essential integral membrane acyltransferase KEEP 274279..274305 274279 274305 I NA NA IG230_Rv0228-Rv0229c KEEP 274306..274986 274306 274986 - 226 15607370 - Rv0229c COG1487R II.C.5 nonessential hypothetical protein KEEP 274983..275963 274983 275963 - 326 15607371 php Rv0230c COG1735R IV.I nonessential phosphotriesterase KEEP 275964..276057 275964 276057 I NA NA IG232_Rv0230c-Rv0231 KEEP 276058..277764 276058 277764 + 568 15607372 fadE4 Rv0231 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE4 KEEP 277765..277898 277765 277898 I NA NA IG233_Rv0231-Rv0232 KEEP 277899..278588 277899 278588 + 229 15607373 - Rv0232 COG1309K I.J.1 nonessential TetR/ACRR family transcriptional regulator KEEP 278585..279529 278585 279524 + 314 15607374 nrdB Rv0233 COG0208F I.F.3 nonessential ribonucleotide-diphosphate reductase subunit beta KEEP 278585..279529 279525 279529 + 314 15607374 nrdB Rv0233 COG0208F I.F.3 nonessential ribonucleotide-diphosphate reductase subunit beta Only Marin et al 2022 KEEP 279530..279604 279530 279601 I NA NA IG235_Rv0233-Rv0234c Only Marin et al 2022 KEEP 279530..279604 279602 279604 I NA NA IG235_Rv0233-Rv0234c KEEP 279605..281140 279605 281140 - 511 57116704 gabD1 Rv0234c COG1012C I.A.1 nonessential succinic semialdehyde dehydrogenase KEEP 281141..281165 281141 281165 I NA NA IG236_Rv0234c-Rv0235c KEEP 281166..282614 281166 282614 - 482 15607376 - Rv0235c - II.C.5 nonessential transmembrane protein KEEP 282615..282648 282615 282648 I NA NA IG237_Rv0235c-Rv0236c KEEP 282649..286851 282649 286851 - 1400 15607377 - Rv0236c - VI essential transmembrane protein KEEP 286852..286897 286852 286897 I NA NA IG238_Rv0236c-Rv0236A KEEP 286898..287071 286898 287071 - 57 57116705 - Rv0236A - II.C.5 nonessential hypothetical protein KEEP 287072..287185 287072 287185 I NA NA IG239_Rv0236A-Rv0237 KEEP 287186..288352 287186 288352 + 388 57116706 lpqI Rv0237 COG1472G II.C.1 nonessential lipoprotein LpqI KEEP 288353..288427 288353 288427 I NA NA IG240_Rv0237-Rv0238 KEEP 288428..289042 288428 289042 + 204 15607379 - Rv0238 COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 289043..289103 289043 289103 I NA NA IG241_Rv0238-Rv0239 KEEP 289104..289337 289104 289337 + 77 15607380 - Rv0239 - V nonessential hypothetical protein KEEP 289338..289344 289338 289344 I NA NA IG242_Rv0239-Rv0240 KEEP 289345..289782 289345 289782 + 145 15607381 - Rv0240 COG1848R V nonessential hypothetical protein KEEP 289783..289811 289783 289811 I NA NA IG243_Rv0240-Rv0241c KEEP 289812..290654 289812 290654 - 280 15607382 - Rv0241c COG2030I V nonessential hypothetical protein KEEP 290655..290664 290655 290664 I NA NA IG244_Rv0241c-Rv0242c KEEP 290665..292029 290665 292029 - 454 15607383 fabG Rv0242c COG1028IQR I.H.1 nonessential 3-ketoacyl-(acyl-carrier-protein) reductase KEEP 292030..292170 292030 292170 I NA NA IG245_Rv0242c-Rv0243 KEEP 292171..293493 292171 293493 + 440 15607384 fadA2 Rv0243 COG0183I I.A.3 nonessential acetyl-CoA acetyltransferase KEEP 293494..293797 293494 293723 I NA NA IG246_Rv0243-Rv0244c KEEP 293494..293797 293724 293792 I NA NA IG246_Rv0243-Rv0244c Only Marin et al 2022 KEEP 293494..293797 293793 293797 I NA NA IG246_Rv0243-Rv0244c KEEP 293798..295633 293798 294284 - 611 15607385 fadE5 Rv0244c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE5 KEEP 293798..295633 294285 294337 - 611 15607385 fadE5 Rv0244c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE5 Only Marin et al 2022 KEEP 293798..295633 294338 295633 - 611 15607385 fadE5 Rv0244c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE5 KEEP 295634..296004 295634 296004 I NA NA IG247_Rv0244c-Rv0245 KEEP 296005..296493 296005 296493 + 162 15607386 - Rv0245 COG1853R I.B.7 nonessential oxidoreductase KEEP 296494..296808 296494 296808 I NA NA IG248_Rv0245-Rv0246 KEEP 296809..298119 296809 298119 + 436 15607387 - Rv0246 - II.C.5 nonessential integral membrane protein KEEP 298116..298862 298116 298862 - 248 15607388 - Rv0247c COG0479C I.B.7 nonessential fumarate reductase iron-sulfur subunit KEEP 298863..300803 298863 300803 - 646 15607389 sdhA Rv0248c COG1053C I.B.7 nonessential succinate dehydrogenase flavoprotein subunit KEEP 300804..300833 300804 300833 I NA NA IG251_Rv0248c-Rv0249c KEEP 300834..301655 300834 301655 - 273 15607390 - Rv0249c - II.C.5 essential succinate dehydrogenase membrane anchor subunit KEEP 301656..301734 301656 301734 I NA NA IG252_Rv0249c-Rv0250c KEEP 301735..302028 301735 302028 - 97 15607391 - Rv0250c - V nonessential hypothetical protein KEEP 302029..302172 302029 302172 I NA NA IG253_Rv0250c-Rv0251c KEEP 302173..302652 302173 302652 - 159 15607392 hsp Rv0251c COG0071O III.B nonessential heat shock protein hsp (heat-stress-induced ribosome-binding protein A) KEEP 302653..302865 302653 302865 I NA NA IG254_Rv0251c-Rv0252 KEEP 302866..305427 302866 305427 + 853 15607393 nirB Rv0252 COG1251C I.B.6b nonessential nitrite reductase large subunit KEEP 305428..305452 305428 305452 I NA NA IG255_Rv0252-Rv0253 KEEP 305453..305809 305453 305809 + 118 15607394 nirD Rv0253 COG2146PR I.B.6b nonessential nitrite reductase [NAD(P)H] small subunit NirD KEEP 305810..305824 305810 305824 I NA NA IG256_Rv0253-Rv0254c KEEP 305825..306349 305825 306349 - 174 15607395 cobU Rv0254c COG2087H I.G.13 nonessential bifunctional cobinamide kinase/cobinamide phosphate guanylyltransferase KEEP 306350..306373 306350 306373 I NA NA IG257_Rv0254c-Rv0255c KEEP 306374..307858 306374 307858 - 494 57116707 cobQ1 Rv0255c COG1492H I.G.13 nonessential cobyric acid synthase KEEP 307859..307876 307859 307876 I NA NA IG258_Rv0255c-Rv0256c KEEP 307877..309547 307877 308320 - 556 57116708 PPE2 Rv0256c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 307877..309547 308321 308413 - 556 57116708 PPE2 Rv0256c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 307877..309547 308414 309083 - 556 57116708 PPE2 Rv0256c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 307877..309547 309084 309191 - 556 57116708 PPE2 Rv0256c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 307877..309547 309192 309547 - 556 57116708 PPE2 Rv0256c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 309548..309698 309548 309698 I NA NA IG259_Rv0256c-Rv0257 KEEP 309699..310073 309699 309926 + 124 57116709 - Rv0257 - V nonessential hypothetical protein KEEP 309699..310073 309927 310073 + 124 57116709 - Rv0257 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 310074..310293 310074 310110 I NA NA IG260_Rv0257-Rv0258c Only Marin et al 2022 KEEP 310074..310293 310111 310293 I NA NA IG260_Rv0257-Rv0258c KEEP 310294..310749 310294 310749 - 151 15607399 - Rv0258c - V nonessential hypothetical protein KEEP 310750..310773 310750 310773 I NA NA IG261_Rv0258c-Rv0259c KEEP 310774..311517 310774 311517 - 247 15607400 - Rv0259c COG2138S V nonessential hypothetical protein KEEP 311514..312659 311514 312659 - 381 15607401 - Rv0260c COG0745TK,COG1587H I.J.2 nonessential bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein KEEP 312660..312758 312660 312758 I NA NA IG263_Rv0260c-Rv0261c KEEP 312759..314168 312759 314168 - 469 15607402 narK3 Rv0261c COG2223P III.A.4 nonessential integral membrane nitrite extrusion protein NarK3 KEEP 314169..314308 314169 314308 I NA NA IG264_Rv0261c-Rv0262c KEEP 314309..314854 314309 314854 - 181 15607403 aac Rv0262c COG0456R IV.D nonessential aminoglycoside 2'-N-acetyltransferase AAC (AAC(2')-IC) KEEP 314855..314863 314855 314863 I NA NA IG265_Rv0262c-Rv0263c KEEP 314864..315766 314864 315766 - 300 15607404 - Rv0263c COG1984E V nonessential hypothetical protein KEEP 315767..315782 315767 315782 I NA NA IG266_Rv0263c-Rv0264c KEEP 315783..316415 315783 316415 - 210 15607405 - Rv0264c COG2049E V nonessential hypothetical protein KEEP 316416..316510 316416 316510 I NA NA IG267_Rv0264c-Rv0265c KEEP 316511..317503 316511 317503 - 330 57116710 - Rv0265c COG0614P III.A.2 nonessential periplasmic IRON-transport lipoprotein KEEP 317504..317524 317504 317524 I NA NA IG268_Rv0265c-Rv0266c KEEP 317525..321154 317525 321154 - 1209 15607407 oplA Rv0266c COG0145EQ,COG0146EQ IV.I nonessential 5-oxoprolinase KEEP 321155..321330 321155 321330 I NA NA IG269_Rv0266c-Rv0267 KEEP 321331..322722 321331 322722 + 463 15607408 narU Rv0267 COG2223P III.A.4 nonessential integral membrane nitrite extrusion protein NarU KEEP 322723..322763 322723 322763 I NA NA IG270_Rv0267-Rv0268c KEEP 322764..323273 322764 323273 - 169 15607409 - Rv0268c COG2161D VI nonessential hypothetical protein KEEP 323274..323337 323274 323337 I NA NA IG271_Rv0268c-Rv0269c KEEP 323338..324531 323338 324531 - 397 15607410 - Rv0269c COG3285L V nonessential hypothetical protein KEEP 324532..324566 324532 324566 I NA NA IG272_Rv0269c-Rv0270 KEEP 324567..326249 324567 326249 + 560 15607411 fadD2 Rv0270 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 326250..326265 326250 326265 I NA NA IG273_Rv0270-Rv0271c KEEP 326266..328461 326266 328461 - 731 15607412 fadE6 Rv0271c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE6 KEEP 328462..328574 328462 328574 I NA NA IG274_Rv0271c-Rv0272c KEEP 328575..329708 328575 329708 - 377 15607413 - Rv0272c - VI nonessential hypothetical protein KEEP 329705..330325 329705 330325 - 206 15607414 - Rv0273c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 330326..330421 330326 330421 I NA NA IG276_Rv0273c-Rv0274 KEEP 330422..331003 330422 331003 + 193 15607415 - Rv0274 COG0346E V nonessential hypothetical protein KEEP 330933..331658 330933 331658 - 241 57116711 - Rv0275c COG1309K I.A.3 nonessential TetR family transcriptional regulator KEEP 331659..331747 331659 331747 I NA NA IG278_Rv0275c-Rv0276 KEEP 331748..332668 331748 332668 + 306 15607417 - Rv0276 COG3662S V nonessential hypothetical protein KEEP 332669..332707 332669 332698 I NA NA IG279_Rv0276-Rv0277c KEEP 332669..332707 332699 332707 I NA NA IG279_Rv0276-Rv0277c Only Marin et al 2022 KEEP 332708..333136 332708 333136 - 142 15607418 - Rv0277c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 333137..333436 333137 333141 I NA NA IG280_Rv0277c-Rv0278c Annotation + Marin et al 2022 DISCARD 333137..333436 333142 333156 I NA NA IG280_Rv0277c-Rv0278c KEEP 333137..333436 333157 333223 I NA NA IG280_Rv0277c-Rv0278c Annotation + Marin et al 2022 DISCARD 333137..333436 333224 333291 I NA NA IG280_Rv0277c-Rv0278c KEEP 333137..333436 333292 333406 I NA NA IG280_Rv0277c-Rv0278c Annotation + Marin et al 2022 DISCARD 333137..333436 333407 333435 I NA NA IG280_Rv0277c-Rv0278c KEEP 333137..333436 333436 333436 I NA NA IG280_Rv0277c-Rv0278c Annotation + Marin et al 2022 DISCARD 333437..336310 333437 336310 - 957 57116712 PE_PGRS3 Rv0278c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 336311..336559 336311 336385 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336311..336559 336386 336398 I NA NA IG281_Rv0278c-Rv0279c repeat KEEP 336311..336559 336399 336400 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336311..336559 336401 336401 I NA NA IG281_Rv0278c-Rv0279c repeat KEEP 336311..336559 336402 336405 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336311..336559 336406 336495 I NA NA IG281_Rv0278c-Rv0279c repeat KEEP 336311..336559 336496 336497 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336311..336559 336498 336502 I NA NA IG281_Rv0278c-Rv0279c repeat KEEP 336311..336559 336503 336504 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336311..336559 336505 336533 I NA NA IG281_Rv0278c-Rv0279c repeat KEEP 336311..336559 336534 336537 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336311..336559 336538 336538 I NA NA IG281_Rv0278c-Rv0279c repeat KEEP 336311..336559 336539 336540 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336311..336559 336541 336544 I NA NA IG281_Rv0278c-Rv0279c repeat KEEP 336311..336559 336545 336546 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336311..336559 336547 336551 I NA NA IG281_Rv0278c-Rv0279c repeat KEEP 336311..336559 336552 336559 I NA NA IG281_Rv0278c-Rv0279c repeat Annotation + Marin et al 2022 DISCARD 336560..339073 336560 337173 - 837 57116713 PE_PGRS4 Rv0279c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 336560..339073 337174 337264 - 837 57116713 PE_PGRS4 Rv0279c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 336560..339073 337265 337381 - 837 57116713 PE_PGRS4 Rv0279c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 336560..339073 337382 337491 - 837 57116713 PE_PGRS4 Rv0279c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 336560..339073 337492 337617 - 837 57116713 PE_PGRS4 Rv0279c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 336560..339073 337618 337713 - 837 57116713 PE_PGRS4 Rv0279c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 336560..339073 337714 339073 - 837 57116713 PE_PGRS4 Rv0279c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 339074..339363 339074 339148 I NA NA IG282_Rv0279c-Rv0280 repeat Annotation + Marin et al 2022 DISCARD 339074..339363 339149 339363 I NA NA IG282_Rv0279c-Rv0280 repeat KEEP 339364..340974 339364 339714 + 536 57116714 PPE3 Rv0280 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 339364..340974 339715 339822 + 536 57116714 PPE3 Rv0280 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 339364..340974 339823 340428 + 536 57116714 PPE3 Rv0280 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 339364..340974 340429 340470 + 536 57116714 PPE3 Rv0280 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 339364..340974 340471 340471 + 536 57116714 PPE3 Rv0280 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 339364..340974 340472 340484 + 536 57116714 PPE3 Rv0280 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 339364..340974 340485 340974 + 536 57116714 PPE3 Rv0280 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 340975..340997 340975 340997 I NA NA IG283_Rv0280-Rv0281 KEEP 340998..341906 340998 341204 + 302 15607422 - Rv0281 COG3315Q V nonessential hypothetical protein KEEP 340998..341906 341205 341267 + 302 15607422 - Rv0281 COG3315Q V nonessential hypothetical protein Only Marin et al 2022 KEEP 340998..341906 341268 341906 + 302 15607422 - Rv0281 COG3315Q V nonessential hypothetical protein KEEP 341907..342129 341907 342129 I NA NA IG284_Rv0281-Rv0282 KEEP 342130..344025 342130 344025 + 631 15607423 - Rv0282 COG0464O V essential hypothetical protein KEEP 344022..345638 344022 345638 + 538 15607424 - Rv0283 - II.C.5 essential hypothetical protein KEEP 345635..349627 345635 349627 + 1330 15607425 - Rv0284 COG1674D II.C.5 essential hypothetical protein KEEP 349624..349932 349624 349932 + 102 57116715 PE5 Rv0285 - IV.C.1 PE/PPE/PGRS essential PE family protein KEEP 349933..349934 349933 349934 I NA NA IG288_Rv0285-Rv0286 repeat KEEP 349935..351476 349935 350295 + 513 57116716 PPE4 Rv0286 - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 349935..351476 350296 350360 + 513 57116716 PPE4 Rv0286 - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 349935..351476 350361 351476 + 513 57116716 PPE4 Rv0286 - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 351477..351524 351477 351524 I NA NA IG289_Rv0286-Rv0287 KEEP 351525..351818 351525 351569 + 97 15607428 esxG Rv0287 - V nonessential hypothetical protein KEEP 351525..351818 351570 351659 + 97 15607428 esxG Rv0287 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 351525..351818 351660 351818 + 97 15607428 esxG Rv0287 - V nonessential hypothetical protein KEEP 351819..351847 351819 351847 I NA NA IG290_Rv0287-Rv0288 KEEP 351848..352138 351848 351889 + 96 15607429 esxH Rv0288 COG4842S VI nonessential low molecular weight protein antigen 7 ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) KEEP 351848..352138 351890 351940 + 96 15607429 esxH Rv0288 COG4842S VI nonessential low molecular weight protein antigen 7 ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) Only Marin et al 2022 KEEP 351848..352138 351941 352138 + 96 15607429 esxH Rv0288 COG4842S VI nonessential low molecular weight protein antigen 7 ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) KEEP 352139..352148 352139 352148 I NA NA IG291_Rv0288-Rv0289 KEEP 352149..353036 352149 353036 + 295 15607430 - Rv0289 - V essential hypothetical protein KEEP 353037..353082 353037 353082 I NA NA IG292_Rv0289-Rv0290 KEEP 353083..354501 353083 354501 + 472 15607431 - Rv0290 - II.C.5 essential transmembrane protein KEEP 354498..355883 354498 355883 + 461 15607432 mycP3 Rv0291 COG1404O II.C.5 essential membrane-anchored mycosin KEEP 355880..356875 355880 356875 + 331 15607433 - Rv0292 - II.C.5 essential transmembrane protein KEEP 356862..358064 356862 358064 - 400 15607434 - Rv0293c COG0596R V nonessential hypothetical protein KEEP 358065..358170 358065 358170 I NA NA IG296_Rv0293c-Rv0294 KEEP 358171..358956 358171 358956 + 261 15607435 tam Rv0294 COG4106R IV.H nonessential trans-aconitate methyltransferase tam KEEP 358945..359748 358945 359748 - 267 15607436 - Rv0295c COG4424S V nonessential hypothetical protein KEEP 359749..359757 359749 359757 I NA NA IG298_Rv0295c-Rv0296c KEEP 359758..361155 359758 361155 - 465 57116717 - Rv0296c COG3119P I.C.5 nonessential sulfatase KEEP 361156..361333 361156 361333 I NA NA IG299_Rv0296c-Rv0297 KEEP 361334..363109 361334 361633 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 361334..363109 361634 361726 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 361334..363109 361727 361739 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 361334..363109 361740 361973 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 361334..363109 361974 361986 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 361334..363109 361987 362010 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 361334..363109 362011 362619 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 361334..363109 362620 362748 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 361334..363109 362749 362750 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 361334..363109 362751 362764 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 361334..363109 362765 362768 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 361334..363109 362769 362916 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 361334..363109 362917 362959 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 361334..363109 362960 363020 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 361334..363109 363021 363109 + 591 57116718 PE_PGRS5 Rv0297 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 363110..363251 363110 363251 I NA NA IG300_Rv0297-Rv0298 KEEP 363252..363479 363252 363479 + 75 15607439 - Rv0298 - VI nonessential hypothetical protein KEEP 363476..363778 363476 363778 + 100 15607440 - Rv0299 COG0012J VI nonessential hypothetical protein KEEP 363779..363825 363779 363825 I NA NA IG302_Rv0299-Rv0300 KEEP 363826..364047 363826 364047 + 73 15607441 - Rv0300 - V nonessential hypothetical protein KEEP 364044..364469 364044 364469 + 141 15607442 - Rv0301 COG1487R V nonessential hypothetical protein KEEP 364470..364604 364470 364604 I NA NA IG304_Rv0301-Rv0302 KEEP 364605..365237 364605 365237 + 210 15607443 - Rv0302 COG1309K I.J.1 nonessential TetR/ACRR family transcriptional regulator KEEP 365234..366142 365234 366142 + 302 15607444 - Rv0303 COG1028IQR VI nonessential dehydrogenase/reductase KEEP 366143..366149 366143 366149 I NA NA IG306_Rv0303-Rv0304c KEEP 366150..372764 366150 372764 - 2204 57116719 PPE5 Rv0304c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372765..372819 372765 372776 I NA NA IG307_Rv0304c-Rv0305c repeat KEEP 372765..372819 372777 372819 I NA NA IG307_Rv0304c-Rv0305c repeat Annotation + Marin et al 2022 DISCARD 372820..375711 372820 372834 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 372835 373193 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 372820..375711 373194 373249 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 373250 373279 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 372820..375711 373280 373372 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 373373 373393 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 372820..375711 373394 373471 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 373472 373526 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 372820..375711 373527 373657 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 373658 373971 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 372820..375711 373972 374026 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 374027 374050 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 372820..375711 374051 374185 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 374186 374463 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 372820..375711 374464 374983 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 374984 375258 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 372820..375711 375259 375329 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 372820..375711 375330 375711 - 963 57116720 PPE6 Rv0305c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 375712..375913 375712 375913 I NA NA IG308_Rv0305c-Rv0306 KEEP 375914..376585 375914 376585 + 223 15607447 - Rv0306 COG0778C I.G.13 nonessential putative oxidoreductase KEEP 376573..377055 376573 377055 - 160 15607448 - Rv0307c - VI nonessential hypothetical protein KEEP 377056..377112 377056 377112 I NA NA IG310_Rv0307c-Rv0308 KEEP 377113..377829 377113 377829 + 238 15607449 - Rv0308 COG0671I II.C.5 nonessential integral membrane protein KEEP 377830..377930 377830 377930 I NA NA IG311_Rv0308-Rv0309 KEEP 377931..378587 377931 378587 + 218 15607450 - Rv0309 COG3786S VI nonessential hypothetical protein KEEP 378588..378656 378588 378656 I NA NA IG312_Rv0309-Rv0310c KEEP 378657..379148 378657 379148 - 163 15607451 - Rv0310c - V nonessential hypothetical protein KEEP 379149..379171 379149 379171 I NA NA IG313_Rv0310c-Rv0311 KEEP 379172..380401 379172 380401 + 409 15607452 - Rv0311 - VI essential hypothetical protein KEEP 380402..380555 380402 380555 I NA NA IG314_Rv0311-Rv0312 KEEP 380556..382418 380556 382418 + 620 15607453 - Rv0312 COG0443O V essential hypothetical protein KEEP 382419..382489 382419 382489 I NA NA IG315_Rv0312-Rv0313 KEEP 382490..382876 382490 382876 + 128 15607454 - Rv0313 - V nonessential hypothetical protein KEEP 382877..382878 382877 382878 I NA NA IG316_Rv0313-Rv0314c KEEP 382879..383541 382879 383541 - 220 15607455 - Rv0314c - II.C.5 nonessential hypothetical protein KEEP 383542..383601 383542 383601 I NA NA IG317_Rv0314c-Rv0315 KEEP 383602..384486 383602 384486 + 294 15607456 - Rv0315 COG2273G II.B.4 nonessential beta-1,3-glucanase precursor KEEP 384487..384534 384487 384534 I NA NA IG318_Rv0315-Rv0316 KEEP 384535..385149 384535 385149 + 204 15607457 - Rv0316 COG4829Q II.B.6 nonessential muconolactone isomerase KEEP 385150..385172 385150 385172 I NA NA IG319_Rv0316-Rv0317c KEEP 385173..385943 385173 385943 - 256 15607458 glpQ2 Rv0317c COG0584C I.C.1 nonessential glycerophosphoryl diester phosphodiesterase KEEP 385944..386304 385944 386304 I NA NA IG320_Rv0317c-Rv0318c KEEP 386305..387099 386305 387099 - 264 57116721 - Rv0318c COG0428P II.C.5 nonessential integral membrane protein KEEP 387100..387147 387100 387147 I NA NA IG321_Rv0318c-Rv0319 KEEP 387148..387816 387148 387816 + 222 15607460 pcp Rv0319 COG2039O II.B.3 nonessential pyrrolidone-carboxylate peptidase KEEP 387817..387887 387817 387887 I NA NA IG322_Rv0319-Rv0320 KEEP 387888..388550 387888 388550 + 220 15607461 - Rv0320 - VI nonessential hypothetical protein KEEP 388551..388581 388551 388581 I NA NA IG323_Rv0320-Rv0321 KEEP 388582..389154 388582 389154 + 190 15607462 dcd Rv0321 COG0717F I.F.3 nonessential deoxycytidine triphosphate deaminase KEEP 389155..389259 389155 389259 I NA NA IG324_Rv0321-Rv0322 KEEP 389260..390591 389260 390591 + 443 15607463 udgA Rv0322 COG1004M I.C.3 nonessential UDP-glucose 6-dehydrogenase UdgA KEEP 390580..391251 390580 391251 - 223 15607464 - Rv0323c COG2120S V nonessential hypothetical protein KEEP 391252..391351 391252 391351 I NA NA IG326_Rv0323c-Rv0324 KEEP 391352..392032 391352 392032 + 226 15607465 - Rv0324 COG0607P,COG0640K I.J.1 nonessential ArsR family transcriptional regulator KEEP 392033..392038 392033 392038 I NA NA IG327_Rv0324-Rv0325 KEEP 392039..392263 392039 392263 + 74 15607466 - Rv0325 COG0500QR VI nonessential hypothetical protein KEEP 392264..392272 392264 392272 I NA NA IG328_Rv0325-Rv0326 KEEP 392273..392728 392273 392728 + 151 15607467 - Rv0326 COG0500QR VI essential hypothetical protein KEEP 392696..394045 392696 394045 - 449 15607468 cyp135A1 Rv0327c COG2124Q IV.F nonessential cytochrome P450 135A1 KEEP 394046..394110 394046 394110 I NA NA IG330_Rv0327c-Rv0328 KEEP 394111..394713 394111 394713 + 200 15607469 - Rv0328 COG1309K I.J.1 nonessential TetR/AcrR family transcriptional regulator KEEP 394694..395320 394694 395320 - 208 15607470 - Rv0329c COG0500QR V nonessential hypothetical protein KEEP 395321..395346 395321 395346 I NA NA IG332_Rv0329c-Rv0330c KEEP 395347..396087 395347 396087 - 246 15607471 - Rv0330c COG1309K VI nonessential hypothetical protein KEEP 396088..396200 396088 396200 I NA NA IG333_Rv0330c-Rv0331 KEEP 396201..397367 396201 397367 + 388 15607472 - Rv0331 COG0446R VI nonessential dehydrogenase/reductase KEEP 397368..397441 397368 397441 I NA NA IG334_Rv0331-Rv0332 KEEP 397442..398227 397442 398227 + 261 15607473 - Rv0332 - V nonessential hypothetical protein KEEP 398228..398253 398228 398253 I NA NA IG335_Rv0332-Rv0333 KEEP 398254..398628 398254 398628 + 124 15607474 - Rv0333 - VI nonessential hypothetical protein KEEP 398629..398657 398629 398657 I NA NA IG336_Rv0333-Rv0334 KEEP 398658..399524 398658 399524 + 288 15607475 rmlA Rv0334 COG1209M I.C.3 essential alpha-D-glucose-1-phosphate thymidylyltransferase RmlA KEEP 399525..399534 399525 399534 I NA NA IG337_Rv0334-Rv0335c KEEP 399535..400050 399535 400050 - 171 57116722 PE6 Rv0335c - IV.C.1 PE/PPE/PGRS essential PE family protein KEEP 400051..400191 400051 400146 I NA NA IG338_Rv0335c-Rv0336 repeat KEEP 400051..400191 400147 400191 I NA NA IG338_Rv0335c-Rv0336 repeat Annotation + Marin et al 2022 DISCARD 400192..401703 400192 401703 + 503 15607477 - Rv0336 - VI repeat13E12 nonessential 13E12 repeat family protein Annotation + Marin et al 2022 DISCARD 401704..401872 401704 401706 I NA NA IG339_Rv0336-Rv0337c Annotation + Marin et al 2022 DISCARD 401704..401872 401707 401872 I NA NA IG339_Rv0336-Rv0337c KEEP 401873..403162 401873 403162 - 429 15607478 aspC Rv0337c COG0436E I.D.2 essential aminotransferase AlaT KEEP 403163..403192 403163 403192 I NA NA IG340_Rv0337c-Rv0338c KEEP 403193..405841 403193 405841 - 882 15607479 - Rv0338c COG0247C VI essential iron-sulfur-binding reductase KEEP 405842..405949 405842 405949 I NA NA IG341_Rv0338c-Rv0339c KEEP 405950..408448 405950 408448 - 832 15607480 - Rv0339c COG2197TK,COG2771K I.J.1 nonessential transcriptional regulatory protein KEEP 408449..408633 408449 408633 I NA NA IG342_Rv0339c-Rv0340 DR-emb KEEP 408634..409173 408634 409173 + 179 15607481 - Rv0340 - V DR-emb-inh nonessential hypothetical protein KEEP 409174..409361 409174 409361 I NA NA IG343_Rv0340-Rv0341 DR-emb KEEP 409362..410801 409362 410551 + 479 15607482 iniB Rv0341 - VI DR-emb-inh nonessential isoniazid inductible gene protein INIB KEEP 409362..410801 410552 410570 + 479 15607482 iniB Rv0341 - VI DR-emb-inh nonessential isoniazid inductible gene protein INIB Only Marin et al 2022 KEEP 409362..410801 410571 410801 + 479 15607482 iniB Rv0341 - VI DR-emb-inh nonessential isoniazid inductible gene protein INIB KEEP 410802..410837 410802 410837 I NA NA IG344_Rv0341-Rv0342 KEEP 410838..412760 410838 412760 + 640 15607483 iniA Rv0342 COG0699R VI DR-emb-inh nonessential isoniazid inductible gene protein INIA KEEP 412757..414238 412757 414238 + 493 15607484 iniC Rv0343 COG0699R VI DR-emb-inh nonessential isoniazid inductible gene protein INIC KEEP 414239..414380 414239 414380 I NA NA IG346_Rv0343-Rv0344c KEEP 414381..414941 414381 414941 - 186 15607485 lpqJ Rv0344c - II.C.1 nonessential lipoprotein LpqJ KEEP 414942..415049 414942 415049 I NA NA IG347_Rv0344c-Rv0345 KEEP 415050..415460 415050 415460 + 136 15607486 - Rv0345 COG2068R V nonessential hypothetical protein KEEP 415461..415501 415461 415501 I NA NA IG348_Rv0345-Rv0346c KEEP 415502..416965 415502 416965 - 487 57116723 ansP2 Rv0346c COG1113E III.A.1 nonessential L-asparagine ABC transporter permease KEEP 416966..417303 416966 417303 I NA NA IG349_Rv0346c-Rv0347 KEEP 417304..418290 417304 418290 + 328 15607488 - Rv0347 - II.C.4 essential hypothetical protein KEEP 418291..418292 418291 418292 I NA NA IG350_Rv0347-Rv0348 KEEP 418293..418946 418293 418946 + 217 15607489 - Rv0348 COG1396K I.J.1 nonessential transcriptional regulatory protein KEEP 418947..418948 418947 418948 I NA NA IG351_Rv0348-Rv0349 KEEP 418949..419608 418949 419608 + 219 15607490 - Rv0349 - VI nonessential hypothetical protein KEEP 419609..419834 419609 419834 I NA NA IG352_Rv0349-Rv0350 KEEP 419835..421712 419835 421712 + 625 15607491 dnaK Rv0350 COG0443O III.B essential molecular chaperone DnaK KEEP 421709..422416 421709 422416 + 235 15607492 grpE Rv0351 COG0576O III.B essential GRPE protein (HSP-70 cofactor) KEEP 422417..422451 422417 422451 I NA NA IG354_Rv0351-Rv0352 KEEP 422452..423639 422452 423639 + 395 57116724 dnaJ1 Rv0352 COG0484O III.B essential chaperone protein DnaJ1 KEEP 423639..424019 423639 424006 + 126 15607494 hspR Rv0353 COG0789K III.B nonessential HEAT shock protein transcriptional repressor HspR KEEP 423639..424019 424007 424019 + 126 15607494 hspR Rv0353 COG0789K III.B nonessential HEAT shock protein transcriptional repressor HspR Only Marin et al 2022 KEEP 424020..424268 424020 424150 I NA NA IG356_Rv0353-Rv0354c Annotation + Marin et al 2022 DISCARD 424020..424268 424151 424268 I NA NA IG356_Rv0353-Rv0354c KEEP 424269..424694 424269 424694 - 141 57116725 PPE7 Rv0354c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424695..424776 424695 424776 I NA NA IG357_Rv0354c-Rv0355c repeat KEEP 424777..434679 424777 424842 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 424843 425033 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 425034 425095 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 425096 425154 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 425155 425167 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 425168 425272 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 425273 425283 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 425284 425593 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 425594 426575 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 426576 426680 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 426681 426735 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 426736 426861 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 426862 426909 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 426910 426998 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 426999 427069 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 427070 427200 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 427201 427295 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 427296 427383 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 427384 428402 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 428403 428503 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 428504 428524 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 428525 428762 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 428763 429118 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 429119 429181 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 429182 429631 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 429632 429716 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 429717 429790 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 429791 430174 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 430175 431042 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 431043 431094 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 431095 431125 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 431126 431184 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 431185 431191 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 431192 431263 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 431264 431272 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 431273 431442 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 431443 431453 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 431454 431551 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 431552 431883 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 431884 431935 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 431936 432374 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 432375 432436 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 432437 432532 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 432533 432592 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 432593 432604 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 432605 432804 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 432805 433690 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 433691 433801 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 433802 433847 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 433848 433930 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 433931 433939 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 433940 434006 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 434007 434226 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 424777..434679 434227 434311 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 424777..434679 434312 434679 - 3300 57116726 PPE8 Rv0355c COG1357S IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 434680..434829 434680 434829 I NA NA IG358_Rv0355c-Rv0356c KEEP 434830..435474 434830 435474 - 214 15607497 - Rv0356c COG2050Q V nonessential hypothetical protein KEEP 435471..436769 435471 436769 - 432 15607498 purA Rv0357c COG0104F I.F.1 essential adenylosuccinate synthetase KEEP 436770..436859 436770 436859 I NA NA IG360_Rv0357c-Rv0358 KEEP 436860..437507 436860 437507 + 215 15607499 - Rv0358 - V nonessential hypothetical protein KEEP 437508..437517 437508 437517 I NA NA IG361_Rv0358-Rv0359 KEEP 437518..438297 437518 438297 + 259 15607500 - Rv0359 COG1994R II.C.5 nonessential integral membrane protein KEEP 438298..438301 438298 438301 I NA NA IG362_Rv0359-Rv0360c KEEP 438302..438739 438302 438739 - 145 15607501 - Rv0360c - V nonessential hypothetical protein KEEP 438740..438821 438740 438821 I NA NA IG363_Rv0360c-Rv0361 KEEP 438822..439649 438822 439649 + 275 15607502 - Rv0361 - II.C.4 nonessential hypothetical protein KEEP 439650..439870 439650 439870 I NA NA IG364_Rv0361-Rv0362 KEEP 439871..441253 439871 441253 + 460 15607503 mgtE Rv0362 COG2239P III.A.2 nonessential Mg2+ transport transmembrane protein MgtE KEEP 441254..441264 441254 441264 I NA NA IG365_Rv0362-Rv0363c KEEP 441265..442299 441265 442299 - 344 15607504 fba Rv0363c COG0191G I.B.1 nonessential fructose-bisphosphate aldolase KEEP 442300..442394 442300 442394 I NA NA IG366_Rv0363c-Rv0364 KEEP 442395..443078 442395 443078 + 227 15607505 - Rv0364 COG0586S II.C.5 nonessential transmembrane protein KEEP 443067..444197 443067 444197 - 376 15607506 - Rv0365c COG4833G V nonessential hypothetical protein KEEP 444198..444221 444198 444221 I NA NA IG368_Rv0365c-Rv0366c KEEP 444222..444815 444222 444815 - 197 15607507 - Rv0366c COG4185S V nonessential hypothetical protein KEEP 444816..444843 444816 444843 I NA NA IG369_Rv0366c-Rv0367c KEEP 444844..445233 444844 445233 - 129 15607508 - Rv0367c - VI nonessential hypothetical protein KEEP 445234..445313 445234 445313 I NA NA IG370_Rv0367c-Rv0368c KEEP 445314..446525 445314 446525 - 403 15607509 - Rv0368c COG3552R V nonessential hypothetical protein KEEP 446526..446530 446526 446530 I NA NA IG371_Rv0368c-Rv0369c KEEP 446531..447046 446531 447046 - 171 15607510 - Rv0369c COG3427S II.C.5 nonessential membrane oxidoreductase KEEP 447047..447146 447047 447146 I NA NA IG372_Rv0369c-Rv0370c KEEP 447147..448043 447147 448043 - 298 15607511 - Rv0370c COG0714R I.B.7 nonessential oxidoreductase KEEP 448040..448633 448040 448633 - 197 15607512 - Rv0371c COG2068R V nonessential hypothetical protein KEEP 448630..449385 448630 449385 - 251 15607513 - Rv0372c COG1975O V essential hypothetical protein KEEP 449386..449403 449386 449403 I NA NA IG375_Rv0372c-Rv0373c KEEP 449404..451803 449404 451803 - 799 15607514 - Rv0373c COG1529C VI nonessential carbon monoxyde dehydrogenase large subunit KEEP 451800..452279 451800 452279 - 159 15607515 - Rv0374c COG2080C VI nonessential carbon monoxyde dehydrogenase small subunit KEEP 452280..452293 452280 452293 I NA NA IG377_Rv0374c-Rv0375c KEEP 452294..453154 452294 453154 - 286 15607516 - Rv0375c COG1319C VI nonessential carbon monoxyde dehydrogenase medium subunit KEEP 453155..453229 453155 453229 I NA NA IG378_Rv0375c-Rv0376c KEEP 453230..454372 453230 454372 - 380 15607517 - Rv0376c COG1975O V nonessential hypothetical protein KEEP 454373..454420 454373 454420 I NA NA IG379_Rv0376c-Rv0377 KEEP 454421..455386 454421 455386 + 321 15607518 - Rv0377 COG0583K I.J.1 nonessential LysR family transcriptional regulator KEEP 455387..455636 455387 455636 I NA NA IG380_Rv0377-Rv0378 KEEP 455637..455858 455637 455858 + 73 15607519 - Rv0378 - V nonessential glycine rich protein KEEP 455859..455976 455859 455976 I NA NA IG381_Rv0378-Rv0379 KEEP 455977..456192 455977 456192 + 71 57116727 secE2 Rv0379 COG3360S III.D nonessential protein transport protein KEEP 456193..456267 456193 456206 I NA NA IG382_Rv0379-Rv0380c KEEP 456193..456267 456207 456212 I NA NA IG382_Rv0379-Rv0380c Only Marin et al 2022 KEEP 456193..456267 456213 456267 I NA NA IG382_Rv0379-Rv0380c KEEP 456268..456819 456268 456819 - 183 15607521 - Rv0380c COG0566J IV.H nonessential RNA methyltransferase KEEP 456820..456914 456820 456914 I NA NA IG383_Rv0380c-Rv0381c KEEP 456915..457823 456915 457823 - 302 15607522 - Rv0381c - VI nonessential hypothetical protein KEEP 457824..457840 457824 457840 I NA NA IG384_Rv0381c-Rv0382c KEEP 457841..458380 457841 458380 - 179 57116728 pyrE Rv0382c COG0461F I.F.2 nonessential orotate phosphoribosyltransferase KEEP 458381..458460 458381 458460 I NA NA IG385_Rv0382c-Rv0383c KEEP 458461..459315 458461 459315 - 284 15607524 - Rv0383c - VI essential hypothetical protein KEEP 459316..459455 459316 459455 I NA NA IG386_Rv0383c-Rv0384c KEEP 459456..462002 459456 459876 - 848 15607525 clpB Rv0384c COG0542O III.B essential endopeptidase ATP binding protein KEEP 459456..462002 459877 459930 - 848 15607525 clpB Rv0384c COG0542O III.B essential endopeptidase ATP binding protein Only Marin et al 2022 KEEP 459456..462002 459931 460996 - 848 15607525 clpB Rv0384c COG0542O III.B essential endopeptidase ATP binding protein KEEP 459456..462002 460997 461069 - 848 15607525 clpB Rv0384c COG0542O III.B essential endopeptidase ATP binding protein Only Marin et al 2022 KEEP 459456..462002 461070 461349 - 848 15607525 clpB Rv0384c COG0542O III.B essential endopeptidase ATP binding protein KEEP 459456..462002 461350 461432 - 848 15607525 clpB Rv0384c COG0542O III.B essential endopeptidase ATP binding protein Only Marin et al 2022 KEEP 459456..462002 461433 462002 - 848 15607525 clpB Rv0384c COG0542O III.B essential endopeptidase ATP binding protein KEEP 462003..462134 462003 462134 I NA NA IG387_Rv0384c-Rv0385 KEEP 462135..463307 462135 463307 + 390 15607526 - Rv0385 COG0543HC,COG1017C VI nonessential hypothetical protein KEEP 463308..463410 463308 463410 I NA NA IG388_Rv0385-Rv0386 KEEP 463411..466668 463411 466668 + 1085 15607527 - Rv0386 COG2114T,COG2771K,COG3903R I.J.1 nonessential LuxR/UHPA family transcriptional regulator KEEP 466669..466671 466669 466671 I NA NA IG389_Rv0386-Rv0387c KEEP 466672..467406 466672 467406 - 244 15607528 - Rv0387c - V PE/PPE/PGRS nonessential PPE family protein KEEP 467407..467458 467407 467458 I NA NA IG390_Rv0387c-Rv0388c repeat KEEP 467459..468001 467459 468001 - 180 57116729 PPE9 Rv0388c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 468002..468334 468002 468334 I NA NA IG391_Rv0388c-Rv0389 KEEP 468335..469594 468335 469594 + 419 15607530 purT Rv0389 COG0027F I.F.1 nonessential phosphoribosylglycinamide formyltransferase 2 KEEP 469591..470013 469591 470013 + 140 15607531 - Rv0390 COG0607P V nonessential hypothetical protein KEEP 470010..471230 470010 471230 + 406 15607532 metZ Rv0391 COG0626E I.D.2 nonessential O-succinylhomoserine sulfhydrylase KEEP 471227..472639 471227 472442 - 470 15607533 ndhA Rv0392c COG1252C II.C.5 nonessential membrane NADH dehydrogenase KEEP 471227..472639 472443 472496 - 470 15607533 ndhA Rv0392c COG1252C II.C.5 nonessential membrane NADH dehydrogenase Marin et al 2022 + homoplasy analysis DISCARD 471227..472639 472497 472639 - 470 15607533 ndhA Rv0392c COG1252C II.C.5 nonessential membrane NADH dehydrogenase KEEP 472640..472780 472640 472780 I NA NA IG395_Rv0392c-Rv0393 KEEP 472781..474106 472781 473740 + 441 15607534 - Rv0393 - VI repeat13E12 nonessential 13E12 repeat family protein KEEP 472781..474106 473741 474045 + 441 15607534 - Rv0393 - VI repeat13E12 nonessential 13E12 repeat family protein Annotation + Marin et al 2022 DISCARD 472781..474106 474046 474046 + 441 15607534 - Rv0393 - VI repeat13E12 nonessential 13E12 repeat family protein KEEP 472781..474106 474047 474106 + 441 15607534 - Rv0393 - VI repeat13E12 nonessential 13E12 repeat family protein Annotation + Marin et al 2022 DISCARD 474107..474121 474107 474109 I NA NA IG396_Rv0393-Rv0394c Annotation + Marin et al 2022 DISCARD 474107..474121 474110 474121 I NA NA IG396_Rv0393-Rv0394c KEEP 474122..474841 474122 474841 - 239 15607535 - Rv0394c - VI nonessential hypothetical protein KEEP 474842..474939 474842 474939 I NA NA IG397_Rv0394c-Rv0395 KEEP 474940..475344 474940 475344 + 134 15607536 - Rv0395 - VI nonessential hypothetical protein KEEP 475345..475349 475345 475349 I NA NA IG398_Rv0395-Rv0396 KEEP 475350..475742 475350 475742 + 130 15607537 - Rv0396 - VI nonessential hypothetical protein KEEP 475743..475815 475743 475806 I NA NA IG399_Rv0396-Rv0397 KEEP 475743..475815 475807 475815 I NA NA IG399_Rv0396-Rv0397 Annotation + Marin et al 2022 DISCARD 475816..476184 475816 476111 + 122 15607538 - Rv0397 - VI repeat13E12 nonessential 13E12 repeat family protein Annotation + Marin et al 2022 DISCARD 475816..476184 476112 476124 + 122 15607538 - Rv0397 - VI repeat13E12 nonessential 13E12 repeat family protein KEEP 475816..476184 476125 476183 + 122 15607538 - Rv0397 - VI repeat13E12 nonessential 13E12 repeat family protein Annotation + Marin et al 2022 DISCARD 475816..476184 476184 476184 + 122 15607538 - Rv0397 - VI repeat13E12 nonessential 13E12 repeat family protein KEEP 476185..476678 476185 476678 I NA NA IG400_Rv0397-Rv0398c KEEP 476679..477320 476679 477320 - 213 15607539 - Rv0398c - VI nonessential hypothetical protein KEEP 477321..477326 477321 477326 I NA NA IG401_Rv0398c-Rv0399c KEEP 477327..478556 477327 478556 - 409 15607540 lpqK Rv0399c COG1680V II.C.1 essential lipoprotein LpqK KEEP 478557..478565 478557 478565 I NA NA IG402_Rv0399c-Rv0400c KEEP 478566..479753 478566 479753 - 395 15607541 fadE7 Rv0400c COG1960I I.A.3 essential acyl-CoA dehydrogenase FADE7 KEEP 479754..479788 479754 479788 I NA NA IG403_Rv0400c-Rv0401 KEEP 479789..480160 479789 480160 + 123 15607542 - Rv0401 - II.C.5 nonessential transmembrane protein KEEP 480161..480354 480161 480354 I NA NA IG404_Rv0401-Rv0402c KEEP 480355..483231 480355 483231 - 958 15607543 mmpL1 Rv0402c COG2409R II.C.4 nonessential transmembrane transport protein MmpL1 KEEP 483228..483656 483228 483656 - 142 15607544 mmpS1 Rv0403c - II.C.4 nonessential membrane protein KEEP 483657..483976 483657 483976 I NA NA IG406_Rv0403c-Rv0404 KEEP 483977..485734 483977 485734 + 585 15607545 fadD30 Rv0404 COG0318IQ I.A.3 essential acyl-CoA synthetase KEEP 485731..489939 485731 488166 + 1402 15607546 pks6 Rv0405 COG3321Q I.I nonessential membrane bound polyketide synthase KEEP 485731..489939 488167 488222 + 1402 15607546 pks6 Rv0405 COG3321Q I.I nonessential membrane bound polyketide synthase Only Marin et al 2022 KEEP 485731..489939 488223 489939 + 1402 15607546 pks6 Rv0405 COG3321Q I.I nonessential membrane bound polyketide synthase KEEP 489887..490705 489887 490705 - 272 15607547 - Rv0406c COG0491R VI nonessential beta lactamase like protein KEEP 490706..490782 490706 490782 I NA NA IG409_Rv0406c-Rv0407 KEEP 490783..491793 490783 491793 + 336 15607548 fgd1 Rv0407 COG2141C I.B.7 nonessential F420-dependent glucose-6-phosphate dehydrogenase KEEP 491786..493858 491786 493858 + 690 15607549 pta Rv0408 COG0280C,COG0857R I.A.1 nonessential phosphate acetyltransferase KEEP 493851..495008 493851 495008 + 385 15607550 ackA Rv0409 COG0282C I.B.6c nonessential acetate kinase KEEP 495009..495061 495009 495061 I NA NA IG412_Rv0409-Rv0410c KEEP 495062..497314 495062 496253 - 750 15607551 pknG Rv0410c COG0515RTKL I.J.3 essential serine/threonine-protein kinase PKNG (protein kinase G) (STPK G) KEEP 495062..497314 496254 496354 - 750 15607551 pknG Rv0410c COG0515RTKL I.J.3 essential serine/threonine-protein kinase PKNG (protein kinase G) (STPK G) Only Marin et al 2022 KEEP 495062..497314 496355 497314 - 750 15607551 pknG Rv0410c COG0515RTKL I.J.3 essential serine/threonine-protein kinase PKNG (protein kinase G) (STPK G) KEEP 497314..498300 497314 498300 - 328 15607552 glnH Rv0411c COG0834ET III.A.1 essential glutamine-binding lipoprotein KEEP 498300..499619 498300 499619 - 439 15607553 - Rv0412c - II.C.5 essential hypothetical protein KEEP 499620..499712 499620 499712 I NA NA IG415_Rv0412c-Rv0413 KEEP 499713..500366 499713 500366 + 217 15607554 mutT3 Rv0413 COG0494LR II.A.5 nonessential 7,8-dihydro-8-oxoguanine-triphosphatase KEEP 500350..501018 500350 501018 - 222 15607555 thiE Rv0414c COG0352H I.G.8 essential thiamine-phosphate pyrophosphorylase KEEP 501019..501147 501019 501147 I NA NA IG417_Rv0414c-Rv0415 KEEP 501148..502170 501148 502170 + 340 15607556 thiO Rv0415 COG0665E I.B.7 essential thiamine biosynthesis oxidoreductase ThiO KEEP 502167..502373 502167 502373 + 68 15607557 thiS Rv0416 COG2104H VII essential sulfur carrier protein ThiS KEEP 502366..503124 502366 503124 + 252 15607558 thiG Rv0417 COG2022H I.G.8 essential thiazole synthase KEEP 503125..503495 503125 503495 I NA NA IG420_Rv0417-Rv0418 KEEP 503496..504998 503496 504998 + 500 15607559 lpqL Rv0418 COG2234R II.C.1 nonessential lipoprotein aminopeptidase LpqL KEEP 504999..505085 504999 505085 I NA NA IG421_Rv0418-Rv0419 KEEP 505086..506582 505086 506582 + 498 15607560 lpqM Rv0419 COG2321R II.C.1 nonessential lipoprotein peptidase LpqM KEEP 506561..506971 506561 506971 - 136 15607561 - Rv0420c - II.C.5 nonessential transmembrane protein KEEP 506972..507131 506972 507131 I NA NA IG423_Rv0420c-Rv0421c KEEP 507132..507761 507132 507761 - 209 15607562 - Rv0421c COG3571R V nonessential hypothetical protein KEEP 507758..508555 507758 508555 - 265 15607563 thiD Rv0422c COG0351H I.G.8 essential phosphomethylpyrimidine kinase KEEP 508556..508581 508556 508581 I NA NA IG425_Rv0422c-Rv0423c KEEP 508582..510225 508582 510225 - 547 15607564 thiC Rv0423c COG0422H I.G.7 essential thiamine biosynthesis protein ThiC KEEP 510226..510376 510226 510376 I NA NA IG426_Rv0423c-Rv0424c KEEP 510377..510652 510377 510652 - 91 15607565 - Rv0424c - VI nonessential hypothetical protein KEEP 510653..510701 510653 510701 I NA NA IG427_Rv0424c-Rv0425c KEEP 510702..515321 510702 515321 - 1539 15607566 ctpH Rv0425c COG0474P III.A.2 essential metal cation transporting P-type ATPase CtpH KEEP 515322..515372 515322 515372 I NA NA IG428_Rv0425c-Rv0426c KEEP 515373..515816 515373 515816 - 147 15607567 - Rv0426c - II.C.5 nonessential hypothetical protein KEEP 515817..516016 515817 516016 I NA NA IG429_Rv0426c-Rv0427c KEEP 516017..516892 516017 516892 - 291 15607568 xthA Rv0427c COG0708L II.A.5 essential exodeoxyribonuclease III protein KEEP 516893..516894 516893 516894 I NA NA IG430_Rv0427c-Rv0428c KEEP 516895..517803 516895 517803 - 302 15607569 - Rv0428c COG0454KR VI nonessential hypothetical protein KEEP 517803..518396 517803 518396 - 197 15607570 def Rv0429c COG0242J II.A.6 essential peptide deformylase KEEP 518397..518732 518397 518732 I NA NA IG432_Rv0429c-Rv0430 KEEP 518733..519041 518733 519041 + 102 15607571 - Rv0430 - V essential hypothetical protein KEEP 519042..519072 519042 519072 I NA NA IG433_Rv0430-Rv0431 KEEP 519073..519567 519073 519567 + 164 15607572 - Rv0431 - II.C.2 nonessential putative tuberculin related peptide KEEP 519568..519599 519568 519599 I NA NA IG434_Rv0431-Rv0432 KEEP 519600..520322 519600 520322 + 240 15607573 sodC Rv0432 COG2032P III.F nonessential periplasmic superoxide dismutase [Cu-Zn] SodC KEEP 520323..521454 520323 521454 + 376 15607574 - Rv0433 COG2170S V nonessential carboxylate-amine ligase KEEP 521455..521513 521455 521513 I NA NA IG436_Rv0433-Rv0434 KEEP 521514..522167 521514 522167 + 217 15607575 - Rv0434 COG2802R V nonessential hypothetical protein KEEP 522168..522346 522168 522346 I NA NA IG437_Rv0434-Rv0435c KEEP 522347..524533 522347 524533 - 728 15607576 - Rv0435c COG0464O III.C nonessential putative ATPase KEEP 524530..525390 524530 525390 - 286 15607577 pssA Rv0436c COG1183I I.H.3 nonessential CDP-diacylglycerol--serine O-phosphatidyltransferase KEEP 525387..526082 525387 526082 - 231 15607578 psd Rv0437c COG0688I I.H.3 nonessential phosphatidylserine decarboxylase KEEP 526083..526142 526083 526142 I NA NA IG440_Rv0437c-Rv0438c KEEP 526143..527360 526143 527360 - 405 57116730 moeA2 Rv0438c COG0303H I.G.4 nonessential molybdopterin biosynthesis protein MoeA2 KEEP 527361..527378 527361 527378 I NA NA IG441_Rv0438c-Rv0439c KEEP 527379..528314 527379 528314 - 311 15607580 - Rv0439c COG1028IQR VI nonessential short chain dehydrogenase KEEP 528315..528607 528315 528607 I NA NA IG442_Rv0439c-Rv0440 KEEP 528608..530230 528608 530230 + 540 15607581 groEL Rv0440 COG0459O III.B essential chaperonin GroEL KEEP 530231..530295 530231 530295 I NA NA IG443_Rv0440-Rv0441c KEEP 530296..530724 530296 530724 - 142 15607582 - Rv0441c - VI nonessential hypothetical protein KEEP 530725..530750 530725 530750 I NA NA IG444_Rv0441c-Rv0442c KEEP 530751..532214 530751 531535 - 487 57116731 PPE10 Rv0442c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 530751..532214 531536 531591 - 487 57116731 PPE10 Rv0442c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 530751..532214 531592 532214 - 487 57116731 PPE10 Rv0442c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 532215..532395 532215 532395 I NA NA IG445_Rv0442c-Rv0443 KEEP 532396..532911 532396 532911 + 171 15607584 - Rv0443 - V nonessential hypothetical protein KEEP 532912..533090 532912 533090 I NA NA IG446_Rv0443-Rv0444c KEEP 533091..533789 533091 533789 - 232 15607585 - Rv0444c COG5343S V nonessential hypothetical protein KEEP 533790..533832 533790 533832 I NA NA IG447_Rv0444c-Rv0445c KEEP 533833..534396 533833 534396 - 187 15607586 sigK Rv0445c COG1595K II.A.7 nonessential RNA polymerase sigma factor SigK KEEP 534397..534444 534397 534444 I NA NA IG448_Rv0445c-Rv0446c KEEP 534445..535215 534445 535215 - 256 15607587 - Rv0446c COG3752S II.C.5 nonessential transmembrane protein KEEP 535216..535223 535216 535223 I NA NA IG449_Rv0446c-Rv0447c KEEP 535224..536507 535224 536507 - 427 15607588 ufaA1 Rv0447c COG2230M I.H.2 nonessential cyclopropane-fatty-acyl-phospholipid synthase KEEP 536504..537169 536504 537169 - 221 15607589 - Rv0448c COG3496S V nonessential hypothetical protein KEEP 537170..537228 537170 537228 I NA NA IG451_Rv0448c-Rv0449c KEEP 537229..538548 537229 538548 - 439 15607590 - Rv0449c COG2907R V nonessential hypothetical protein KEEP 538549..538587 538549 538587 I NA NA IG452_Rv0449c-Rv0450c KEEP 538588..541491 538588 538774 - 967 15607591 mmpL4 Rv0450c COG2409R II.C.4 essential transmembrane transport protein MmpL4 KEEP 538588..541491 538775 538840 - 967 15607591 mmpL4 Rv0450c COG2409R II.C.4 essential transmembrane transport protein MmpL4 Only Marin et al 2022 KEEP 538588..541491 538841 541491 - 967 15607591 mmpL4 Rv0450c COG2409R II.C.4 essential transmembrane transport protein MmpL4 KEEP 541488..541910 541488 541910 - 140 15607592 mmpS4 Rv0451c - II.C.4 nonessential membrane protein KEEP 541911..542141 541911 542141 I NA NA IG454_Rv0451c-Rv0452 KEEP 542142..542852 542142 542852 + 236 15607593 - Rv0452 COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 542853..543173 542853 543173 I NA NA IG455_Rv0452-Rv0453 KEEP 543174..544730 543174 543554 + 518 57116732 PPE11 Rv0453 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 543174..544730 543555 543639 + 518 57116732 PPE11 Rv0453 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 543174..544730 543640 544730 + 518 57116732 PPE11 Rv0453 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 544731..544834 544731 544834 I NA NA IG456_Rv0453-Rv0454 KEEP 544835..545185 544835 545185 + 116 15607595 - Rv0454 COG0009J V nonessential hypothetical protein KEEP 545186..545374 545186 545374 I NA NA IG457_Rv0454-Rv0455c KEEP 545375..545821 545375 545821 - 148 15607596 - Rv0455c - V nonessential hypothetical protein KEEP 545822..545888 545822 545888 I NA NA IG458_Rv0455c-Rv0456c KEEP 545889..546803 545889 546803 - 304 15607597 echA2 Rv0456c COG1024I V nonessential enoyl-CoA hydratase KEEP 546804..547075 546804 547075 I NA NA IG459_Rv0456c-Rv0456A KEEP 547076..547357 547076 547357 - 93 57116733 - Rv0456A COG2337T I.A.3 nonessential hypothetical protein KEEP 547358..547585 547358 547585 I NA NA IG460_Rv0456A-Rv0457c KEEP 547586..549607 547586 549607 - 673 15607598 - Rv0457c COG1505E II.B.3 nonessential peptidase KEEP 549608..549674 549608 549674 I NA NA IG461_Rv0457c-Rv0458 KEEP 549675..551198 549675 551198 + 507 15607599 - Rv0458 COG1012C I.B.7 nonessential aldehyde dehydrogenase KEEP 551198..551689 551198 551689 + 163 15607600 - Rv0459 COG3564S V nonessential hypothetical protein KEEP 551690..551748 551690 551748 I NA NA IG463_Rv0459-Rv0460 KEEP 551749..551988 551749 551988 + 79 15607601 - Rv0460 - VI nonessential hypothetical protein KEEP 551989..552025 551989 552025 I NA NA IG464_Rv0460-Rv0461 KEEP 552026..552550 552026 552550 + 174 15607602 - Rv0461 - II.C.5 nonessential hypothetical protein KEEP 552551..552613 552551 552613 I NA NA IG465_Rv0461-Rv0462 KEEP 552614..554008 552614 554008 + 464 15607603 lpd Rv0462 COG1249C I.B.2 essential dihydrolipoamide dehydrogenase KEEP 554009..554015 554009 554015 I NA NA IG466_Rv0462-Rv0463 KEEP 554016..554309 554016 554309 + 97 15607604 - Rv0463 - II.C.4 nonessential hypothetical protein KEEP 554310..554312 554310 554312 I NA NA IG467_Rv0463-Rv0464c KEEP 554313..554885 554313 554885 - 190 15607605 - Rv0464c COG2128S V nonessential hypothetical protein KEEP 554882..556306 554882 556306 - 474 15607606 - Rv0465c COG1396K,COG3800R I.J.1 nonessential transcriptional regulatory protein KEEP 556307..556457 556307 556457 I NA NA IG469_Rv0465c-Rv0466 KEEP 556458..557252 556458 557252 + 264 15607607 - Rv0466 COG3884I V nonessential hypothetical protein KEEP 557253..557526 557253 557526 I NA NA IG470_Rv0466-Rv0467 KEEP 557527..558813 557527 558813 + 428 57116734 icl Rv0467 COG2224C I.B.4 nonessential isocitrate lyase KEEP 558814..558894 558814 558894 I NA NA IG471_Rv0467-Rv0468 KEEP 558895..559755 558895 559755 + 286 15607609 fadB2 Rv0468 COG1250I I.A.3 nonessential 3-hydroxybutyryl-CoA dehydrogenase KEEP 559756..559887 559756 559887 I NA NA IG472_Rv0468-Rv0469 KEEP 559888..560748 559888 560748 + 286 57116735 umaA Rv0469 COG2230M I.H.2 nonessential mycolic acid synthase KEEP 560749..560847 560749 560847 I NA NA IG473_Rv0469-Rv0470c KEEP 560848..561711 560848 560890 - 287 57116736 pcaA Rv0470c COG2230M VI essential mycolic acid synthase pcaA (cyclopropane synthase) KEEP 560848..561711 560891 560941 - 287 57116736 pcaA Rv0470c COG2230M VI essential mycolic acid synthase pcaA (cyclopropane synthase) Only Marin et al 2022 KEEP 560848..561711 560942 561273 - 287 57116736 pcaA Rv0470c COG2230M VI essential mycolic acid synthase pcaA (cyclopropane synthase) KEEP 560848..561711 561274 561339 - 287 57116736 pcaA Rv0470c COG2230M VI essential mycolic acid synthase pcaA (cyclopropane synthase) Only Marin et al 2022 KEEP 560848..561711 561340 561531 - 287 57116736 pcaA Rv0470c COG2230M VI essential mycolic acid synthase pcaA (cyclopropane synthase) KEEP 560848..561711 561532 561658 - 287 57116736 pcaA Rv0470c COG2230M VI essential mycolic acid synthase pcaA (cyclopropane synthase) Only Marin et al 2022 KEEP 560848..561711 561659 561711 - 287 57116736 pcaA Rv0470c COG2230M VI essential mycolic acid synthase pcaA (cyclopropane synthase) KEEP 561712..561853 561712 561853 I NA NA IG474_Rv0470c-Rv0470A KEEP 561854..562294 561854 562294 - 146 57116737 - Rv0470A COG1575H I.H.2 nonessential hypothetical protein KEEP 562225..562713 562225 562302 - 162 15607612 - Rv0471c - VI nonessential hypothetical protein KEEP 562225..562713 562303 562397 - 162 15607612 - Rv0471c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 562225..562713 562398 562713 - 162 15607612 - Rv0471c - VI nonessential hypothetical protein KEEP 562714..562722 562714 562722 I NA NA IG476_Rv0471c-Rv0472c KEEP 562723..563427 562723 563427 - 234 15607613 - Rv0472c COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 563428..563563 563428 563563 I NA NA IG477_Rv0472c-Rv0473 KEEP 563564..564934 563564 564934 + 456 15607614 - Rv0473 COG2733S II.C.5 nonessential transmembrane protein KEEP 564935..565020 564935 565020 I NA NA IG478_Rv0473-Rv0474 KEEP 565021..565443 565021 565443 + 140 15607615 - Rv0474 COG1396K I.J.1 nonessential transcriptional regulatory protein KEEP 565444..565796 565444 565796 I NA NA IG479_Rv0474-Rv0475 KEEP 565797..566396 565797 566270 + 199 15607616 hbhA Rv0475 - I.J.1 nonessential iron-regulated heparin binding hemagglutinin hbhA (adhesin) KEEP 565797..566396 566271 566345 + 199 15607616 hbhA Rv0475 - I.J.1 nonessential iron-regulated heparin binding hemagglutinin hbhA (adhesin) Only Marin et al 2022 KEEP 565797..566396 566346 566396 + 199 15607616 hbhA Rv0475 - I.J.1 nonessential iron-regulated heparin binding hemagglutinin hbhA (adhesin) KEEP 566397..566507 566397 566507 I NA NA IG480_Rv0475-Rv0476 KEEP 566508..566771 566508 566771 + 87 15607617 - Rv0476 - II.C.5 nonessential transmembrane protein KEEP 566772..566775 566772 566775 I NA NA IG481_Rv0476-Rv0477 KEEP 566776..567222 566776 567222 + 148 15607618 - Rv0477 - VI nonessential hypothetical protein KEEP 567222..567896 567222 567896 + 224 15607619 deoC Rv0478 COG0274F I.F.4 nonessential deoxyribose-phosphate aldolase KEEP 567897..567920 567897 567920 I NA NA IG483_Rv0478-Rv0479c KEEP 567921..568967 567921 568967 - 348 15607620 - Rv0479c - II.C.4 essential hypothetical protein KEEP 568964..569806 568964 569806 - 280 57116738 - Rv0480c COG0388R IV.I nonessential amidohydrolase KEEP 569807..569987 569807 569810 I NA NA IG485_Rv0480c-Rv0481c KEEP 569807..569987 569811 569985 I NA NA IG485_Rv0480c-Rv0481c Only Marin et al 2022 KEEP 569807..569987 569986 569987 I NA NA IG485_Rv0480c-Rv0481c KEEP 569988..570512 569988 570512 - 174 15607622 - Rv0481c - VI nonessential hypothetical protein KEEP 570513..570538 570513 570538 I NA NA IG486_Rv0481c-Rv0482 KEEP 570539..571648 570539 571648 + 369 15607623 murB Rv0482 COG0812M II.C.3 nonessential UDP-N-acetylenolpyruvoylglucosamine reductase KEEP 571649..571709 571649 571709 I NA NA IG487_Rv0482-Rv0483 KEEP 571710..573065 571710 573065 + 451 15607624 lprQ Rv0483 COG1376S II.C.1 nonessential lipoprotein LprQ KEEP 573046..573801 573046 573801 - 251 15607625 - Rv0484c COG4221R I.B.7 nonessential short-chain type oxidoreductase KEEP 573802..573983 573802 573983 I NA NA IG489_Rv0484c-Rv0485 KEEP 573984..575300 573984 575300 + 438 15607626 - Rv0485 COG1940KG I.J.1 nonessential transcriptional regulatory protein KEEP 575301..575347 575301 575347 I NA NA IG490_Rv0485-Rv0486 KEEP 575348..576790 575348 576790 + 480 15607627 - Rv0486 COG0438M IV.H nonessential mannosyltransferase KEEP 576787..577338 576787 577280 + 183 15607628 - Rv0487 - V nonessential hypothetical protein KEEP 576787..577338 577281 577338 + 183 15607628 - Rv0487 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 577339..577663 577339 577503 I NA NA IG492_Rv0487-Rv0488 Only Marin et al 2022 KEEP 577339..577663 577504 577663 I NA NA IG492_Rv0487-Rv0488 KEEP 577664..578269 577664 578269 + 201 15607629 - Rv0488 COG1279R II.C.5 nonessential integral membrane protein KEEP 578270..578425 578270 578425 I NA NA IG493_Rv0488-Rv0489 KEEP 578426..579175 578426 579175 + 249 57116739 gpm1 Rv0489 COG0588G I.B.1 nonessential phosphoglyceromutase KEEP 579176..579348 579176 579348 I NA NA IG494_Rv0489-Rv0490 KEEP 579349..580581 579349 580565 + 410 15607631 senX3 Rv0490 COG0642T I.J.2 essential putative two component sensor histidine kinase SENX3 KEEP 579349..580581 580566 580581 + 410 15607631 senX3 Rv0490 COG0642T I.J.2 essential putative two component sensor histidine kinase SENX3 Only Marin et al 2022 KEEP 580582..580808 580582 580808 I NA NA IG495_Rv0490-Rv0491 Marin et al 2022 + homoplasy analysis DISCARD 580809..581492 580809 580821 + 227 15607632 regX3 Rv0491 COG0745TK I.J.2 nonessential two component sensory transduction protein RegX3 Only Marin et al 2022 KEEP 580809..581492 580822 581492 + 227 15607632 regX3 Rv0491 COG0745TK I.J.2 nonessential two component sensory transduction protein RegX3 KEEP 581489..583378 581489 583378 - 629 57116740 - Rv0492c COG2303E VI nonessential oxidoreductase GMC-type KEEP 583375..583704 583375 583704 - 109 57116741 - Rv0492A - I.B.7 nonessential hypothetical protein KEEP 583701..584690 583701 584690 - 329 15607634 - Rv0493c - V nonessential hypothetical protein KEEP 584691..584694 584691 584694 I NA NA IG499_Rv0493c-Rv0494 KEEP 584695..585423 584695 585423 + 242 57116742 - Rv0494 COG2186K I.J.1 nonessential GntR family transcriptional regulator KEEP 585424..586314 585424 586314 - 296 15607636 - Rv0495c - V nonessential hypothetical protein KEEP 586315..586393 586315 586393 I NA NA IG501_Rv0495c-Rv0496 KEEP 586394..587380 586394 587380 + 328 15607637 - Rv0496 COG0248FP V nonessential hypothetical protein KEEP 587377..588309 587377 588309 + 310 15607638 - Rv0497 - II.C.5 nonessential transmembrane protein KEEP 588310..588324 588310 588324 I NA NA IG503_Rv0497-Rv0498 KEEP 588325..589167 588325 589167 + 280 15607639 - Rv0498 COG1082G V nonessential hypothetical protein KEEP 589168..589182 589168 589182 I NA NA IG504_Rv0498-Rv0499 KEEP 589183..590058 589183 590058 + 291 15607640 - Rv0499 COG1155C V nonessential hypothetical protein KEEP 590059..590082 590059 590082 I NA NA IG505_Rv0499-Rv0500 KEEP 590083..590970 590083 590970 + 295 15607641 proC Rv0500 COG0345E I.D.1 essential pyrroline-5-carboxylate reductase KEEP 590971..591110 590971 591110 I NA NA IG506_Rv0500-Rv0500A KEEP 591111..591347 591111 591347 + 78 57116743 - Rv0500A COG1910P V nonessential hypothetical protein KEEP 591348..591474 591348 591474 I NA NA IG507_Rv0500A-Rv0500B KEEP 591475..591576 591475 591576 + 33 57116744 - Rv0500B - V nonessential hypothetical protein KEEP 591577..591653 591577 591653 I NA NA IG508_Rv0500B-Rv0501 KEEP 591654..592784 591654 592784 + 376 57116745 galE2 Rv0501 COG0451MG I.A.1 nonessential UDP-glucose 4-epimerase KEEP 592785..592790 592785 592790 I NA NA IG509_Rv0501-Rv0502 KEEP 592791..593867 592791 593867 + 358 15607643 - Rv0502 COG0204I V nonessential hypothetical protein KEEP 593868..593870 593868 593870 I NA NA IG510_Rv0502-Rv0503c KEEP 593871..594779 593871 594516 - 302 15607644 cmaA2 Rv0503c COG2230M I.H.2 nonessential cyclopropane-fatty-acyl-phospholipid synthase 2 CMAA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) KEEP 593871..594779 594517 594569 - 302 15607644 cmaA2 Rv0503c COG2230M I.H.2 nonessential cyclopropane-fatty-acyl-phospholipid synthase 2 CMAA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) Only Marin et al 2022 KEEP 593871..594779 594570 594779 - 302 15607644 cmaA2 Rv0503c COG2230M I.H.2 nonessential cyclopropane-fatty-acyl-phospholipid synthase 2 CMAA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) KEEP 594780..594801 594780 594801 I NA NA IG511_Rv0503c-Rv0504c KEEP 594802..595302 594802 595302 - 166 15607645 - Rv0504c - V nonessential hypothetical protein KEEP 595303..595463 595303 595329 I NA NA IG512_Rv0504c-Rv0505c KEEP 595303..595463 595330 595453 I NA NA IG512_Rv0504c-Rv0505c Marin et al 2022 + homoplasy analysis DISCARD 595303..595463 595454 595463 I NA NA IG512_Rv0504c-Rv0505c KEEP 595464..596585 595464 596585 - 373 57116746 serB1 Rv0505c COG0560E I.D.3 nonessential phosphoserine phosphatase KEEP 596586..596758 596586 596758 I NA NA IG513_Rv0505c-Rv0506 KEEP 596759..597202 596759 597202 + 147 15607647 mmpS2 Rv0506 - II.C.4 nonessential membrane protein KEEP 597199..600105 597199 598878 + 968 15607648 mmpL2 Rv0507 COG2409R II.C.4 nonessential transmembrane transport protein MmpL2 KEEP 597199..600105 598879 598932 + 968 15607648 mmpL2 Rv0507 COG2409R II.C.4 nonessential transmembrane transport protein MmpL2 Only Marin et al 2022 KEEP 597199..600105 598933 600105 + 968 15607648 mmpL2 Rv0507 COG2409R II.C.4 nonessential transmembrane transport protein MmpL2 KEEP 600098..600391 600098 600391 + 97 15607649 - Rv0508 COG0526OC V nonessential hypothetical protein KEEP 600392..600440 600392 600440 I NA NA IG516_Rv0508-Rv0509 KEEP 600441..601847 600441 601847 + 468 15607650 hemA Rv0509 COG0373H I.G.12 essential glutamyl-tRNA reductase KEEP 601848..601856 601848 601856 I NA NA IG517_Rv0509-Rv0510 KEEP 601857..602786 601857 602786 + 309 15607651 hemC Rv0510 COG0181H I.G.12 essential porphobilinogen deaminase KEEP 602787..602818 602787 602818 I NA NA IG518_Rv0510-Rv0511 KEEP 602819..604516 602819 604516 + 565 57116747 hemD Rv0511 COG0007H,COG1587H I.D.3 essential uroporphyrin-III C-methyltransferase HemD KEEP 604517..604601 604517 604601 I NA NA IG519_Rv0511-Rv0512 KEEP 604602..605591 604602 605591 + 329 15607653 hemB Rv0512 COG0113H I.G.12 nonessential delta-aminolevulinic acid dehydratase KEEP 605592..605603 605592 605603 I NA NA IG520_Rv0512-Rv0513 KEEP 605604..606152 605604 606152 + 182 15607654 - Rv0513 - II.C.5 nonessential transmembrane protein KEEP 606149..606448 606149 606448 + 99 15607655 - Rv0514 - II.C.5 nonessential transmembrane protein KEEP 606449..606550 606449 606505 I NA NA IG522_Rv0514-Rv0515 KEEP 606449..606550 606506 606550 I NA NA IG522_Rv0514-Rv0515 Annotation + Marin et al 2022 DISCARD 606551..608062 606551 608062 + 503 15607656 - Rv0515 - VI repeat13E12 nonessential 13E12 repeat family protein Annotation + Marin et al 2022 DISCARD 608059..608535 608059 608064 - 158 15607657 - Rv0516c COG1366T V nonessential hypothetical protein Only Marin et al 2022 KEEP 608059..608535 608065 608535 - 158 15607657 - Rv0516c COG1366T V nonessential hypothetical protein KEEP 608536..608745 608536 608745 I NA NA IG524_Rv0516c-Rv0517 KEEP 608746..610056 608746 610056 + 436 15607658 - Rv0517 COG1835I II.C.5 nonessential membrane acyltransferase KEEP 610057..610187 610057 610187 I NA NA IG525_Rv0517-Rv0518 KEEP 610188..610883 610188 610883 + 231 15607659 - Rv0518 COG0443O VI nonessential hypothetical protein KEEP 610884..611171 610884 611171 I NA NA IG526_Rv0518-Rv0519c KEEP 611172..612074 611172 612074 - 300 15607660 - Rv0519c COG0627R II.C.5 nonessential hypothetical protein KEEP 612075..612254 612075 612254 I NA NA IG527_Rv0519c-Rv0520 KEEP 612255..612605 612255 612605 + 116 15607661 - Rv0520 COG0500QR IV.H nonessential hypothetical protein KEEP 612598..612903 612598 612903 + 101 57116748 - Rv0521 - IV.H nonessential hypothetical protein KEEP 612904..613037 612904 613037 I NA NA IG529_Rv0521-Rv0522 KEEP 613038..614342 613038 614342 + 434 57116749 gabP Rv0522 COG1113E III.A.1 nonessential GABA permease GabP KEEP 614326..614721 614326 614721 - 131 15607663 - Rv0523c - V nonessential hypothetical protein KEEP 614722..614834 614722 614834 I NA NA IG531_Rv0523c-Rv0524 KEEP 614835..616223 614835 616223 + 462 15607664 hemL Rv0524 COG0001H I.G.12 essential glutamate-1-semialdehyde aminotransferase KEEP 616223..616831 616223 616831 + 202 15607665 - Rv0525 COG0406G V essential hypothetical protein KEEP 616832..616845 616832 616845 I NA NA IG533_Rv0525-Rv0526 KEEP 616846..617496 616846 617496 + 216 15607666 - Rv0526 COG0526OC VII essential thioredoxin protein KEEP 617493..618272 617493 618272 + 259 57116750 ccdA Rv0527 COG0785O I.B.6a essential cytochrome C-type biogenesis protein CcdA KEEP 618273..618304 618273 618304 I NA NA IG535_Rv0527-Rv0528 KEEP 618305..619894 618305 619894 + 529 15607668 - Rv0528 COG1333O II.C.5 essential transmembrane protein KEEP 619891..620865 619891 620865 + 324 57116751 ccsA Rv0529 COG0755O I.B.6a essential cytochrome C-type biogenesis protein CcsA KEEP 620866..620906 620866 620906 I NA NA IG537_Rv0529-Rv0530 KEEP 620907..622124 620907 622124 + 405 15607670 - Rv0530 COG0455D V nonessential hypothetical protein KEEP 622125..622328 622125 622328 I NA NA IG538_Rv0530-Rv0531 KEEP 622329..622646 622329 622646 + 105 15607671 - Rv0531 - II.C.5 nonessential hypothetical protein KEEP 622647..622792 622647 622792 I NA NA IG539_Rv0531-Rv0532 KEEP 622793..624577 622793 622889 + 594 57116752 PE_PGRS6 Rv0532 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 622793..624577 622890 622945 + 594 57116752 PE_PGRS6 Rv0532 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 622793..624577 622946 623097 + 594 57116752 PE_PGRS6 Rv0532 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 622793..624577 623098 624417 + 594 57116752 PE_PGRS6 Rv0532 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 622793..624577 624418 624577 + 594 57116752 PE_PGRS6 Rv0532 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 624473..625480 624473 625480 - 335 15607673 fabH Rv0533c COG0332I I.H.1 nonessential 3-oxoacyl-(acyl carrier protein) synthase III KEEP 625481..625561 625481 625561 I NA NA IG541_Rv0533c-Rv0534c KEEP 625562..626440 625562 626440 - 292 15607674 menA Rv0534c COG1575H I.G.11 nonessential 1,4-dihydroxy-2-naphthoate octaprenyltransferase KEEP 626441..626456 626441 626456 I NA NA IG542_Rv0534c-Rv0535 KEEP 626457..627251 626457 627251 + 264 15607675 pnp Rv0535 COG0005F I.F.4 nonessential 5'-methylthioadenosine phosphorylase KEEP 627248..628288 627248 628288 + 346 57116753 galE3 Rv0536 COG0451MG I.A.1 nonessential UDP-glucose 4-epimerase KEEP 628289..628297 628289 628297 I NA NA IG544_Rv0536-Rv0537c KEEP 628298..629731 628298 629731 - 477 15607677 - Rv0537c - II.C.5 nonessential integral membrane protein KEEP 629732..630039 629732 630039 I NA NA IG545_Rv0537c-Rv0538 KEEP 630040..631686 630040 631281 + 548 15607678 - Rv0538 - II.C.5 nonessential hypothetical protein KEEP 630040..631686 631282 631440 + 548 15607678 - Rv0538 - II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 630040..631686 631441 631686 + 548 15607678 - Rv0538 - II.C.5 nonessential hypothetical protein KEEP 631687..631742 631687 631742 I NA NA IG546_Rv0538-Rv0539 KEEP 631743..632375 631743 632375 + 210 15607679 - Rv0539 COG0463M IV.H nonessential dolichyl-phosphate sugar synthase KEEP 632372..633034 632372 633034 + 220 15607680 - Rv0540 COG3222S V essential hypothetical protein KEEP 633035..633054 633035 633054 I NA NA IG548_Rv0540-Rv0541c KEEP 633055..634404 633055 634404 - 449 15607681 - Rv0541c - II.C.5 essential integral membrane protein KEEP 634405..634415 634405 634415 I NA NA IG549_Rv0541c-Rv0542c KEEP 634416..635504 634416 635504 - 362 15607682 menE Rv0542c COG0318IQ I.G.11 essential O-succinylbenzoic acid--CoA ligase KEEP 635505..635572 635505 635572 I NA NA IG550_Rv0542c-Rv0543c KEEP 635573..635875 635573 635875 - 100 15607683 - Rv0543c - V nonessential hypothetical protein KEEP 635876..635934 635876 635934 I NA NA IG551_Rv0543c-Rv0544c KEEP 635935..636213 635935 636213 - 92 15607684 - Rv0544c - II.C.5 nonessential transmembrane protein KEEP 636210..637463 636210 637463 - 417 15607685 pitA Rv0545c COG0306P III.A.4 nonessential inorganic phosphate transporter KEEP 637464..637582 637464 637582 I NA NA IG553_Rv0545c-Rv0546c KEEP 637583..637969 637583 637969 - 128 15607686 - Rv0546c COG0346E V nonessential hypothetical protein KEEP 637970..638031 637970 638031 I NA NA IG554_Rv0546c-Rv0547c KEEP 638032..638916 638032 638916 - 294 15607687 - Rv0547c COG1028IQR I.B.7 nonessential short chain dehydrogenase KEEP 638917..639011 638917 639011 I NA NA IG555_Rv0547c-Rv0548c KEEP 639012..639956 639012 639956 - 314 15607688 menB Rv0548c COG0447H I.G.11 nonessential naphthoate synthase KEEP 639957..640227 639957 640227 I NA NA IG556_Rv0548c-Rv0549c KEEP 640228..640641 640228 640641 - 137 15607689 - Rv0549c COG4113R V nonessential hypothetical protein KEEP 640638..640904 640638 640904 - 88 15607690 - Rv0550c COG5302R VI nonessential hypothetical protein KEEP 640905..641095 640905 641095 I NA NA IG558_Rv0550c-Rv0551c KEEP 641096..642811 641096 642734 - 571 15607691 fadD8 Rv0551c COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 641096..642811 642735 642811 - 571 15607691 fadD8 Rv0551c COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 642812..642888 642812 642818 I NA NA IG559_Rv0551c-Rv0552 Only Marin et al 2022 KEEP 642812..642888 642819 642888 I NA NA IG559_Rv0551c-Rv0552 KEEP 642889..644493 642889 644493 + 534 15607692 - Rv0552 COG1574R I.J.1 nonessential hypothetical protein KEEP 644490..645470 644490 645470 + 326 15607693 menC Rv0553 COG4948MR I.G.11 essential O-succinylbenzoate synthase KEEP 645467..646255 645467 646255 + 262 15607694 bpoC Rv0554 COG0596R III.F nonessential peroxidase BpoC KEEP 646256..646297 646256 646297 I NA NA IG562_Rv0554-Rv0555 KEEP 646298..647962 646298 647962 + 554 15607695 menD Rv0555 COG1165H I.G.11 essential 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase KEEP 647959..648474 647959 648474 + 171 15607696 - Rv0556 - II.C.5 essential transmembrane protein KEEP 648475..648535 648475 648535 I NA NA IG564_Rv0556-Rv0557 KEEP 648536..649672 648536 649672 + 378 15607697 pimB Rv0557 COG0438M IV.H essential mannosyltransferase PIMB KEEP 649673..649688 649673 649688 I NA NA IG565_Rv0557-Rv0558 KEEP 649689..650393 649689 650393 + 234 57116754 ubiE Rv0558 COG2226H I.G.11 essential ubiquinone/menaquinone biosynthesis methyltransferase KEEP 650394..650406 650394 650406 I NA NA IG566_Rv0558-Rv0559c KEEP 650407..650745 650407 650745 - 112 15607699 - Rv0559c - VI nonessential hypothetical protein KEEP 650746..650778 650746 650778 I NA NA IG567_Rv0559c-Rv0560c KEEP 650779..651504 650779 651504 - 241 15607700 - Rv0560c COG0500QR IV.H nonessential benzoquinone methyltransferase KEEP 651505..651528 651505 651528 I NA NA IG568_Rv0560c-Rv0561c KEEP 651529..652755 651529 652755 - 408 15607701 - Rv0561c COG0644C I.B.7 nonessential oxidoreductase KEEP 652756..652770 652756 652770 I NA NA IG569_Rv0561c-Rv0562 KEEP 652771..653778 652771 653778 + 335 15607702 grcC1 Rv0562 COG0142H I.G.11 essential polyprenyl-diphosphate synthase KEEP 653779..653878 653779 653878 I NA NA IG570_Rv0562-Rv0563 KEEP 653879..654739 653879 654739 + 286 15607703 htpX Rv0563 COG0501O III.B nonessential heat shock protein HtpX KEEP 654740..654923 654740 654923 I NA NA IG571_Rv0563-Rv0564c KEEP 654924..655949 654924 655949 - 341 15607704 gpsA Rv0564c COG0240C I.H.3 nonessential NAD(P)H-dependent glycerol-3-phosphate dehydrogenase KEEP 655950..656009 655950 656009 I NA NA IG572_Rv0564c-Rv0565c KEEP 656010..657470 656010 657470 - 486 15607705 - Rv0565c COG2072P VI nonessential monooxygenase KEEP 657471..657547 657471 657547 I NA NA IG573_Rv0565c-Rv0566c KEEP 657548..658039 657548 658039 - 163 15607706 - Rv0566c COG1666S V essential nucleotide-binding protein KEEP 658040..658320 658040 658320 I NA NA IG574_Rv0566c-Rv0567 KEEP 658321..659340 658321 659340 + 339 15607707 - Rv0567 COG0500QR IV.H nonessential methyltransferase/methylase KEEP 659341..659449 659341 659449 I NA NA IG575_Rv0567-Rv0568 KEEP 659450..660868 659450 660868 + 472 15607708 cyp135B1 Rv0568 COG2124Q IV.F nonessential cytochrome P450 135B1 KEEP 660869..661002 660869 661002 I NA NA IG576_Rv0568-Rv0569 KEEP 661003..661269 661003 661269 + 88 15607709 - Rv0569 - V nonessential hypothetical protein KEEP 661270..661294 661270 661294 I NA NA IG577_Rv0569-Rv0570 KEEP 661295..663373 661295 663373 + 692 15607710 nrdZ Rv0570 COG0209F I.F.3 nonessential ribonucleoside-diphosphate reductase large subunit NrdZ KEEP 663374..663486 663374 663427 I NA NA IG578_Rv0570-Rv0571c KEEP 663374..663486 663428 663429 I NA NA IG578_Rv0570-Rv0571c Only Marin et al 2022 KEEP 663374..663486 663430 663486 I NA NA IG578_Rv0570-Rv0571c KEEP 663487..664818 663487 664818 - 443 15607711 - Rv0571c COG0596R,COG1926R,COG2267I V nonessential hypothetical protein KEEP 664819..665041 664819 665041 I NA NA IG579_Rv0571c-Rv0572c KEEP 665042..665383 665042 665383 - 113 15607712 - Rv0572c - VI nonessential hypothetical protein KEEP 665384..665850 665384 665850 I NA NA IG580_Rv0572c-Rv0573c KEEP 665851..667242 665851 667242 - 463 15607713 - Rv0573c COG1488H V nonessential nicotinate phosphoribosyltransferase KEEP 667243..667251 667243 667251 I NA NA IG581_Rv0573c-Rv0574c KEEP 667252..668394 667252 668394 - 380 15607714 - Rv0574c COG2843M V nonessential hypothetical protein KEEP 668395..668578 668395 668578 I NA NA IG582_Rv0574c-Rv0575c KEEP 668579..669745 668579 669262 - 388 15607715 - Rv0575c COG0654HC I.B.7 nonessential hypothetical protein KEEP 668579..669745 669263 669314 - 388 15607715 - Rv0575c COG0654HC I.B.7 nonessential hypothetical protein Only Marin et al 2022 KEEP 668579..669745 669315 669745 - 388 15607715 - Rv0575c COG0654HC I.B.7 nonessential hypothetical protein KEEP 669746..669847 669746 669847 I NA NA IG583_Rv0575c-Rv0576 KEEP 669848..671152 669848 671152 + 434 15607716 - Rv0576 COG0640K,COG3832S I.J.1 nonessential ArsR family transcriptional regulator KEEP 671153..671165 671153 671165 I NA NA IG584_Rv0576-Rv0577 KEEP 671166..671951 671166 671951 + 261 15607717 TB27.3 Rv0577 COG3324R V nonessential hypothetical protein KEEP 671952..671995 671952 671995 I NA NA IG585_Rv0577-Rv0578c KEEP 671996..675916 671996 672008 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672009 672011 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672012 672013 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672014 672070 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672071 672103 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672104 672108 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672109 672160 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672161 672246 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672247 672264 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672265 672274 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672275 672442 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + homoplasy analysis DISCARD 671996..675916 672443 672462 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672463 672476 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672477 672524 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672525 672531 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672532 672563 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672564 672647 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672648 672805 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672806 672826 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672827 672919 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672920 672944 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672945 672951 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672952 672954 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 672955 672959 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 672960 673101 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 673102 673623 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 673624 673634 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 673635 673637 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 673638 673646 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 673647 673668 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 673669 673939 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 673940 673995 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 673996 674120 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674121 674132 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674133 674141 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674142 674163 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674164 674217 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674218 674220 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674221 674226 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674227 674233 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674234 674239 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674240 674272 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674273 674310 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674311 674319 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674320 674342 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674343 674358 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674359 674433 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674434 674507 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674508 674545 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674546 674556 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 674557 674779 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 674780 675029 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 675030 675033 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 675034 675405 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 675406 675485 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 675486 675548 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 675549 675554 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 671996..675916 675555 675615 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 671996..675916 675616 675916 - 1306 57116755 PE_PGRS7 Rv0578c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 675917..676237 675917 676237 I NA NA IG586_Rv0578c-Rv0579 KEEP 676238..676996 676238 676996 + 252 15607719 - Rv0579 COG1656S V nonessential hypothetical protein KEEP 676997..677124 676997 677063 I NA NA IG587_Rv0579-Rv0580c KEEP 676997..677124 677064 677124 I NA NA IG587_Rv0579-Rv0580c Only Marin et al 2022 KEEP 677125..677616 677125 677128 - 163 15607720 - Rv0580c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 677125..677616 677129 677616 - 163 15607720 - Rv0580c - V nonessential hypothetical protein KEEP 677617..677709 677617 677709 I NA NA IG588_Rv0580c-Rv0581 KEEP 677710..677925 677710 677925 + 71 15607721 - Rv0581 - V nonessential hypothetical protein KEEP 677922..678329 677922 678329 + 135 15607722 - Rv0582 COG2402R VI nonessential hypothetical protein KEEP 678330..678388 678330 678388 I NA NA IG590_Rv0582-Rv0583c KEEP 678389..679075 678389 679075 - 228 15607723 lpqN Rv0583c - II.C.1 nonessential lipoprotein LpqN KEEP 679076..679228 679076 679228 I NA NA IG591_Rv0583c-Rv0584 KEEP 679229..681862 679229 681862 + 877 15607724 - Rv0584 COG3537G VI nonessential hypothetical protein KEEP 681863..681884 681863 681884 I NA NA IG592_Rv0584-Rv0585c KEEP 681885..684272 681885 684272 - 795 15607725 - Rv0585c COG0392S,COG3642T II.C.5 nonessential integral membrane protein KEEP 684273..684409 684273 684409 I NA NA IG593_Rv0585c-Rv0586 KEEP 684410..685132 684410 685132 + 240 15607726 - Rv0586 COG2186K I.J.1 nonessential GntR family transcriptional regulator KEEP 685129..685926 685129 685344 + 265 15607727 yrbE2A Rv0587 COG0767Q IV.A nonessential integral membrane protein YrbE2a KEEP 685129..685926 685345 685398 + 265 15607727 yrbE2A Rv0587 COG0767Q IV.A nonessential integral membrane protein YrbE2a Only Marin et al 2022 KEEP 685129..685926 685399 685458 + 265 15607727 yrbE2A Rv0587 COG0767Q IV.A nonessential integral membrane protein YrbE2a KEEP 685129..685926 685459 685579 + 265 15607727 yrbE2A Rv0587 COG0767Q IV.A nonessential integral membrane protein YrbE2a Only Marin et al 2022 KEEP 685129..685926 685580 685926 + 265 15607727 yrbE2A Rv0587 COG0767Q IV.A nonessential integral membrane protein YrbE2a KEEP 685928..686815 685928 686122 + 295 15607728 yrbE2B Rv0588 COG0767Q IV.A essential integral membrane protein YrbE2b KEEP 685928..686815 686123 686292 + 295 15607728 yrbE2B Rv0588 COG0767Q IV.A essential integral membrane protein YrbE2b Only Marin et al 2022 KEEP 685928..686815 686293 686374 + 295 15607728 yrbE2B Rv0588 COG0767Q IV.A essential integral membrane protein YrbE2b KEEP 685928..686815 686375 686456 + 295 15607728 yrbE2B Rv0588 COG0767Q IV.A essential integral membrane protein YrbE2b Only Marin et al 2022 KEEP 685928..686815 686457 686762 + 295 15607728 yrbE2B Rv0588 COG0767Q IV.A essential integral membrane protein YrbE2b KEEP 685928..686815 686763 686815 + 295 15607728 yrbE2B Rv0588 COG0767Q IV.A essential integral membrane protein YrbE2b Only Marin et al 2022 KEEP 686816..686820 686816 686820 I NA NA IG596_Rv0588-Rv0589 Only Marin et al 2022 KEEP 686821..688035 686821 686823 + 404 57116756 mce2A Rv0589 COG1463Q IV.A nonessential MCE-family protein MCE2A Only Marin et al 2022 KEEP 686821..688035 686824 687244 + 404 57116756 mce2A Rv0589 COG1463Q IV.A nonessential MCE-family protein MCE2A KEEP 686821..688035 687245 687325 + 404 57116756 mce2A Rv0589 COG1463Q IV.A nonessential MCE-family protein MCE2A Only Marin et al 2022 KEEP 686821..688035 687326 687886 + 404 57116756 mce2A Rv0589 COG1463Q IV.A nonessential MCE-family protein MCE2A KEEP 686821..688035 687887 687969 + 404 57116756 mce2A Rv0589 COG1463Q IV.A nonessential MCE-family protein MCE2A Only Marin et al 2022 KEEP 686821..688035 687970 688035 + 404 57116756 mce2A Rv0589 COG1463Q IV.A nonessential MCE-family protein MCE2A KEEP 688032..688859 688032 688859 + 275 15607730 mce2B Rv0590 COG1463Q IV.A nonessential MCE-family protein MCE2B KEEP 688808..689062 688808 689062 + 84 57116757 - Rv0590A - VI nonessential MCE family-like protein KEEP 689059..690504 689059 690078 + 481 15607731 mce2C Rv0591 COG1463Q IV.A nonessential MCE-family protein MCE2C KEEP 689059..690504 690079 690141 + 481 15607731 mce2C Rv0591 COG1463Q IV.A nonessential MCE-family protein MCE2C Only Marin et al 2022 KEEP 689059..690504 690142 690504 + 481 15607731 mce2C Rv0591 COG1463Q IV.A nonessential MCE-family protein MCE2C KEEP 690501..692027 690501 692027 + 508 15607732 mce2D Rv0592 COG1463Q IV.A nonessential MCE-family protein MCE2D KEEP 692024..693232 692024 693232 + 402 15607733 lprL Rv0593 COG1463Q II.C.1 nonessential MCE-family lipoprotein LprL KEEP 693233..693236 693233 693236 I NA NA IG602_Rv0593-Rv0594 KEEP 693237..694787 693237 694787 + 516 15607734 mce2F Rv0594 COG1463Q IV.A nonessential MCE-family protein MCE2F KEEP 694788..694838 694788 694838 I NA NA IG603_Rv0594-Rv0595c KEEP 694839..695231 694839 695231 - 130 15607735 - Rv0595c COG1487R V nonessential hypothetical protein KEEP 695228..695485 695228 695485 - 85 15607736 - Rv0596c COG4118D V nonessential hypothetical protein KEEP 695486..695667 695486 695667 I NA NA IG605_Rv0596c-Rv0597c KEEP 695668..696903 695668 696903 - 411 15607737 - Rv0597c COG1373R V nonessential hypothetical protein KEEP 696904..697153 696904 697153 I NA NA IG606_Rv0597c-Rv0598c KEEP 697154..697567 697154 697567 - 137 15607738 - Rv0598c - V nonessential hypothetical protein KEEP 697564..697800 697564 697800 - 78 15607739 - Rv0599c COG2002K V nonessential hypothetical protein KEEP 697801..697903 697801 697903 I NA NA IG608_Rv0599c-Rv0600c KEEP 697904..698410 697904 698410 - 168 57116758 - Rv0600c COG0642T I.J.2 nonessential two component sensor kinase KEEP 698411..698523 698411 698523 I NA NA IG609_Rv0600c-Rv0601c KEEP 698524..698994 698524 698994 - 156 15607741 - Rv0601c COG0642T I.J.2 nonessential two component sensor kinase KEEP 698995..699037 698995 699037 I NA NA IG610_Rv0601c-Rv0602c KEEP 699038..699799 699038 699609 - 253 15607742 tcrA Rv0602c COG0745TK I.J.2 nonessential two component DNA binding transcriptional regulatory protein TCRA KEEP 699038..699799 699610 699640 - 253 15607742 tcrA Rv0602c COG0745TK I.J.2 nonessential two component DNA binding transcriptional regulatory protein TCRA Only Marin et al 2022 KEEP 699038..699799 699641 699799 - 253 15607742 tcrA Rv0602c COG0745TK I.J.2 nonessential two component DNA binding transcriptional regulatory protein TCRA KEEP 699800..699855 699800 699855 I NA NA IG611_Rv0602c-Rv0603 KEEP 699856..700167 699856 700167 + 103 15607743 - Rv0603 - VI nonessential hypothetical protein KEEP 700168..700238 700168 700238 I NA NA IG612_Rv0603-Rv0604 KEEP 700239..701189 700239 701189 + 316 15607744 lpqO Rv0604 - II.C.1 nonessential lipoprotein lpqo KEEP 701190..701405 701190 701241 I NA NA IG613_Rv0604-Rv0605 KEEP 701190..701405 701242 701311 I NA NA IG613_Rv0604-Rv0605 Only Marin et al 2022 KEEP 701190..701405 701312 701312 I NA NA IG613_Rv0604-Rv0605 KEEP 701190..701405 701313 701405 I NA NA IG613_Rv0604-Rv0605 Only Marin et al 2022 KEEP 701406..702014 701406 701438 + 202 15607745 - Rv0605 COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 701406..702014 701439 702014 + 202 15607745 - Rv0605 COG2452L IV.B.1 nonessential resolvase KEEP 702016..702759 702016 702054 + 247 15607746 - Rv0606 COG0675L IV.B.1 nonessential hypothetical protein KEEP 702016..702759 702055 702169 + 247 15607746 - Rv0606 COG0675L IV.B.1 nonessential hypothetical protein Only Marin et al 2022 KEEP 702016..702759 702170 702278 + 247 15607746 - Rv0606 COG0675L IV.B.1 nonessential hypothetical protein KEEP 702016..702759 702279 702358 + 247 15607746 - Rv0606 COG0675L IV.B.1 nonessential hypothetical protein Only Marin et al 2022 KEEP 702016..702759 702359 702537 + 247 15607746 - Rv0606 COG0675L IV.B.1 nonessential hypothetical protein KEEP 702016..702759 702538 702627 + 247 15607746 - Rv0606 COG0675L IV.B.1 nonessential hypothetical protein Only Marin et al 2022 KEEP 702016..702759 702628 702759 + 247 15607746 - Rv0606 COG0675L IV.B.1 nonessential hypothetical protein KEEP 702760..702812 702760 702812 I NA NA IG615_Rv0606-Rv0607 KEEP 702813..703199 702813 703199 + 128 15607747 - Rv0607 - VI essential hypothetical protein KEEP 703200..703243 703200 703243 I NA NA IG616_Rv0607-Rv0608 KEEP 703244..703489 703244 703489 + 81 15607748 - Rv0608 COG4423S V nonessential hypothetical protein KEEP 703486..703887 703486 703887 + 133 15607749 - Rv0609 COG3742S V nonessential hypothetical protein KEEP 703830..704057 703830 704057 + 75 57116759 - Rv0609A - V nonessential hypothetical protein KEEP 704058..704751 704058 704751 I NA NA IG619_Rv0609A-Rv0610c KEEP 704752..705909 704752 705909 - 385 15607750 - Rv0610c - VI nonessential hypothetical protein KEEP 705910..705960 705910 705960 I NA NA IG620_Rv0610c-Rv0611c KEEP 705961..706344 705961 706344 - 127 15607751 - Rv0611c - VI nonessential hypothetical protein KEEP 706324..706929 706324 706929 + 201 15607752 - Rv0612 - V nonessential hypothetical protein KEEP 706930..706947 706930 706947 I NA NA IG622_Rv0612-Rv0613c KEEP 706948..709515 706948 709419 - 855 15607753 - Rv0613c COG0653U VI nonessential hypothetical protein KEEP 706948..709515 709420 709489 - 855 15607753 - Rv0613c COG0653U VI nonessential hypothetical protein Only Marin et al 2022 KEEP 706948..709515 709490 709491 - 855 15607753 - Rv0613c COG0653U VI nonessential hypothetical protein KEEP 706948..709515 709492 709515 - 855 15607753 - Rv0613c COG0653U VI nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 709356..710348 709356 709419 + 330 15607754 - Rv0614 - V nonessential hypothetical protein KEEP 709356..710348 709420 709489 + 330 15607754 - Rv0614 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 709356..710348 709490 709491 + 330 15607754 - Rv0614 - V nonessential hypothetical protein KEEP 709356..710348 709492 709544 + 330 15607754 - Rv0614 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 709356..710348 709545 709580 + 330 15607754 - Rv0614 - V nonessential hypothetical protein KEEP 709356..710348 709581 709666 + 330 15607754 - Rv0614 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 709356..710348 709667 710348 + 330 15607754 - Rv0614 - V nonessential hypothetical protein KEEP 710345..710587 710345 710587 + 80 15607755 - Rv0615 - II.C.5 nonessential integral membrane protein KEEP 710584..710850 710584 710850 - 88 15607756 - Rv0616c - VI nonessential hypothetical protein KEEP 710851..711005 710851 711005 I NA NA IG626_Rv0616c-Rv0617 KEEP 711006..711407 711006 711407 + 133 15607757 - Rv0617 COG1848R V nonessential hypothetical protein KEEP 711408..711535 711408 711535 I NA NA IG627_Rv0617-Rv0618 KEEP 711536..712231 711536 711562 + 231 57116760 galTa Rv0618 COG1085C I.A.1 nonessential galactose-1-phosphate uridylyltransferase galTa KEEP 711536..712231 711563 711705 + 231 57116760 galTa Rv0618 COG1085C I.A.1 nonessential galactose-1-phosphate uridylyltransferase galTa Only Marin et al 2022 KEEP 711536..712231 711706 712231 + 231 57116760 galTa Rv0618 COG1085C I.A.1 nonessential galactose-1-phosphate uridylyltransferase galTa KEEP 712174..712719 712174 712719 + 181 57116761 galTb Rv0619 COG1085C I.A.1 nonessential galactose-1-phosphate uridylyltransferase GalTb KEEP 712716..713807 712716 713807 + 363 15607760 galK Rv0620 COG0153G I.A.1 nonessential galactokinase KEEP 713808..714201 713808 714201 I NA NA IG630_Rv0620-Rv0621 KEEP 714202..715266 714202 715266 + 354 15607761 - Rv0621 COG0120G II.C.5 nonessential hypothetical protein KEEP 715267..715369 715267 715369 I NA NA IG631_Rv0621-Rv0622 KEEP 715370..716317 715370 716317 + 315 57116762 - Rv0622 - II.C.5 nonessential hypothetical protein KEEP 716318..716409 716318 716409 I NA NA IG632_Rv0622-Rv0623 KEEP 716410..716664 716410 716626 + 84 15607763 - Rv0623 COG4423S V nonessential hypothetical protein KEEP 716410..716664 716627 716664 + 84 15607763 - Rv0623 COG4423S V nonessential hypothetical protein Only Marin et al 2022 KEEP 716664..717059 716664 716678 + 131 15607764 - Rv0624 COG3742S V nonessential hypothetical protein Only Marin et al 2022 KEEP 716664..717059 716679 717059 + 131 15607764 - Rv0624 COG3742S V nonessential hypothetical protein KEEP 717060..717152 717060 717152 I NA NA IG634_Rv0624-Rv0625c KEEP 717153..717893 717153 717241 - 246 15607765 - Rv0625c COG0398S II.C.5 nonessential transmembrane protein KEEP 717153..717893 717242 717295 - 246 15607765 - Rv0625c COG0398S II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 717153..717893 717296 717639 - 246 15607765 - Rv0625c COG0398S II.C.5 nonessential transmembrane protein KEEP 717153..717893 717640 717717 - 246 15607765 - Rv0625c COG0398S II.C.5 nonessential transmembrane protein Marin et al 2022 + homoplasy analysis DISCARD 717153..717893 717718 717893 - 246 15607765 - Rv0625c COG0398S II.C.5 nonessential transmembrane protein KEEP 717894..718024 717894 718024 I NA NA IG635_Rv0625c-Rv0626 KEEP 718025..718285 718025 718285 + 86 15607766 - Rv0626 COG4118D V nonessential hypothetical protein KEEP 718282..718689 718282 718308 + 135 15607767 - Rv0627 COG1487R V essential hypothetical protein KEEP 718282..718689 718309 718366 + 135 15607767 - Rv0627 COG1487R V essential hypothetical protein Only Marin et al 2022 KEEP 718282..718689 718367 718689 + 135 15607767 - Rv0627 COG1487R V essential hypothetical protein KEEP 718690..718760 718690 718760 I NA NA IG637_Rv0627-Rv0628c KEEP 718761..719912 718761 718810 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein KEEP 718761..719912 718811 718926 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein Only Marin et al 2022 KEEP 718761..719912 718927 719127 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein KEEP 718761..719912 719128 719200 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein Only Marin et al 2022 KEEP 718761..719912 719201 719382 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein KEEP 718761..719912 719383 719546 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein Only Marin et al 2022 KEEP 718761..719912 719547 719636 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein KEEP 718761..719912 719637 719688 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein Only Marin et al 2022 KEEP 718761..719912 719689 719912 - 383 15607768 - Rv0628c COG4398S V essential hypothetical protein KEEP 719913..720004 719913 720004 I NA NA IG638_Rv0628c-Rv0629c KEEP 720005..721732 720005 721732 - 575 15607769 recD Rv0629c COG0507L II.A.5 nonessential exonuclease V alpha chain KEEP 721729..725013 721729 725013 - 1094 15607770 recB Rv0630c COG0210L,COG1074L II.A.5 nonessential exonuclease V beta chain KEEP 725013..728306 725013 725207 - 1097 15607771 recC Rv0631c COG1330L II.A.5 nonessential exonuclease V gamma chain KEEP 725013..728306 725208 725233 - 1097 15607771 recC Rv0631c COG1330L II.A.5 nonessential exonuclease V gamma chain Only Marin et al 2022 KEEP 725013..728306 725234 728306 - 1097 15607771 recC Rv0631c COG1330L II.A.5 nonessential exonuclease V gamma chain KEEP 728307..728582 728307 728582 I NA NA IG641_Rv0631c-Rv0632c KEEP 728583..729278 728583 729278 - 231 15607772 echA3 Rv0632c COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 729279..729326 729279 729326 I NA NA IG642_Rv0632c-Rv0633c KEEP 729327..730166 729327 730166 - 279 15607773 - Rv0633c - VI nonessential hypothetical protein KEEP 730167..730319 730167 730319 I NA NA IG643_Rv0633c-Rv0634c KEEP 730320..731033 730320 731033 - 237 15607774 - Rv0634c COG0491R II.A.1 nonessential glyoxalase II KEEP 731034..731112 731034 731112 I NA NA IG644_Rv0634c-Rv0634A KEEP 731113..731364 731113 731364 + 83 57116763 - Rv0634A - III.F nonessential hypothetical protein KEEP 731365..731711 731365 731711 I NA NA IG645_Rv0634A-Rv0634B KEEP 731712..731879 731712 731879 + 55 57116764 rpmG Rv0634B COG0267J VI nonessential 50S ribosomal protein L33 KEEP 731880..731929 731880 731929 I NA NA IG646_Rv0634B-Rv0635 KEEP 731930..732406 731930 732406 + 158 15607775 - Rv0635 - V essential (3R)-hydroxyacyl-ACP dehydratase subunit HadA KEEP 732393..732821 732393 732821 + 142 15607776 - Rv0636 COG2030I V essential (3R)-hydroxyacyl-ACP dehydratase subunit HadB KEEP 732822..732824 732822 732824 I NA NA IG648_Rv0636-Rv0637 KEEP 732825..733325 732825 733325 + 166 15607777 - Rv0637 - V nonessential (3R)-hydroxyacyl-ACP dehydratase subunit HadC KEEP 733326..733736 733326 733736 I NA NA IG649_Rv0637-Rv0638 KEEP 733737..734222 733737 734222 + 161 57116765 secE Rv0638 COG0690U III.D essential preprotein translocase subunit SecE KEEP 734223..734253 734223 734253 I NA NA IG650_Rv0638-Rv0639 KEEP 734254..734970 734254 734970 + 238 15607779 nusG Rv0639 COG0250K II.A.7 nonessential transcription antitermination protein NusG KEEP 734971..735021 734971 735021 I NA NA IG651_Rv0639-Rv0640 KEEP 735022..735450 735022 735078 + 142 15607780 rplK Rv0640 COG0080J II.A.1 essential 50S ribosomal protein L11 KEEP 735022..735450 735079 735081 + 142 15607780 rplK Rv0640 COG0080J II.A.1 essential 50S ribosomal protein L11 Only Marin et al 2022 KEEP 735022..735450 735082 735450 + 142 15607780 rplK Rv0640 COG0080J II.A.1 essential 50S ribosomal protein L11 KEEP 735451..735516 735451 735516 I NA NA IG652_Rv0640-Rv0641 KEEP 735517..736224 735517 736224 + 235 15607781 rplA Rv0641 COG0081J II.A.1 nonessential 50S ribosomal protein L1 KEEP 736225..736297 736225 736225 I NA NA IG653_Rv0641-Rv0642c KEEP 736225..736297 736226 736297 I NA NA IG653_Rv0641-Rv0642c Only Marin et al 2022 KEEP 736298..737203 736298 737203 - 301 15607782 mmaA4 Rv0642c COG2230M I.H.2 nonessential methoxy mycolic acid synthase KEEP 737204..737267 737204 737267 I NA NA IG654_Rv0642c-Rv0643c KEEP 737268..738149 737268 737307 - 293 15607783 mmaA3 Rv0643c COG2230M I.H.2 essential methoxy mycolic acid synthase KEEP 737268..738149 737308 737390 - 293 15607783 mmaA3 Rv0643c COG2230M I.H.2 essential methoxy mycolic acid synthase Only Marin et al 2022 KEEP 737268..738149 737391 737988 - 293 15607783 mmaA3 Rv0643c COG2230M I.H.2 essential methoxy mycolic acid synthase KEEP 737268..738149 737989 738061 - 293 15607783 mmaA3 Rv0643c COG2230M I.H.2 essential methoxy mycolic acid synthase Only Marin et al 2022 KEEP 737268..738149 738062 738149 - 293 15607783 mmaA3 Rv0643c COG2230M I.H.2 essential methoxy mycolic acid synthase KEEP 738150..738296 738150 738296 I NA NA IG655_Rv0643c-Rv0644c KEEP 738297..739160 738297 738336 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase KEEP 738297..739160 738337 738419 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase Only Marin et al 2022 KEEP 738297..739160 738420 738722 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase KEEP 738297..739160 738723 738788 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase Only Marin et al 2022 KEEP 738297..739160 738789 738921 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase KEEP 738297..739160 738922 738974 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase Only Marin et al 2022 KEEP 738297..739160 738975 738980 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase KEEP 738297..739160 738981 739144 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase Only Marin et al 2022 KEEP 738297..739160 739145 739160 - 287 15607784 mmaA2 Rv0644c COG2230M I.H.2 nonessential methoxy mycolic acid synthase KEEP 739161..739326 739161 739326 I NA NA IG656_Rv0644c-Rv0645c KEEP 739327..740187 739327 740187 - 286 15607785 mmaA1 Rv0645c COG2230M I.H.2 nonessential methoxy mycolic acid synthase KEEP 740188..740233 740188 740233 I NA NA IG657_Rv0645c-Rv0646c KEEP 740234..741139 740234 741139 - 301 15607786 lipG Rv0646c COG0596R II.B.5 nonessential lipase/esterase LipG KEEP 741140..741150 741140 741150 I NA NA IG658_Rv0646c-Rv0647c KEEP 741151..742617 741151 742561 - 488 15607787 - Rv0647c COG0661R V nonessential hypothetical protein KEEP 741151..742617 742562 742617 - 488 15607787 - Rv0647c COG0661R V nonessential hypothetical protein Only Marin et al 2022 KEEP 742618..742718 742618 742638 I NA NA IG659_Rv0647c-Rv0648 Only Marin et al 2022 KEEP 742618..742718 742639 742718 I NA NA IG659_Rv0647c-Rv0648 KEEP 742719..746366 742719 746366 + 1215 15607788 - Rv0648 COG0383G IV.I nonessential alpha-mannosidase KEEP 746363..747037 746363 747037 + 224 57116766 fabD2 Rv0649 - I.H.1 nonessential malonyl CoA-acyl carrier protein transacylase KEEP 747037..747945 747037 747945 + 302 15607790 - Rv0650 COG1940KG I.J.1 nonessential sugar kinase KEEP 747946..748275 747946 747948 I NA NA IG662_Rv0650-Rv0651 KEEP 747946..748275 747949 748000 I NA NA IG662_Rv0650-Rv0651 Only Marin et al 2022 KEEP 747946..748275 748001 748275 I NA NA IG662_Rv0650-Rv0651 KEEP 748276..748812 748276 748812 + 178 15607791 rplJ Rv0651 COG0244J II.A.1 essential 50S ribosomal protein L10 KEEP 748813..748848 748813 748848 I NA NA IG663_Rv0651-Rv0652 KEEP 748849..749241 748849 749241 + 130 15607792 rplL Rv0652 COG0222J II.A.1 essential 50S ribosomal protein L7/L12 KEEP 749234..749929 749234 749929 - 231 15607793 - Rv0653c COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 749930..749999 749930 749999 I NA NA IG665_Rv0653c-Rv0654 KEEP 750000..751505 750000 751505 + 501 15607794 - Rv0654 COG3670Q VI nonessential dioxygenase KEEP 751506..751516 751506 751516 I NA NA IG666_Rv0654-Rv0655 KEEP 751517..752596 751517 752596 + 359 15607795 mkl Rv0655 COG1127Q III.A essential ribonucleotide ABC transporter ATP-binding protein KEEP 752597..752983 752597 752983 I NA NA IG667_Rv0655-Rv0656c KEEP 752984..753367 752984 753367 - 127 15607796 - Rv0656c - V nonessential hypothetical protein KEEP 753368..753461 753368 753461 I NA NA IG668_Rv0656c-Rv0657c KEEP 753462..753617 753462 753617 - 51 15607797 - Rv0657c COG5450K V nonessential hypothetical protein KEEP 753618..753692 753618 753692 I NA NA IG669_Rv0657c-Rv0658c KEEP 753693..754409 753693 754409 - 238 15607798 - Rv0658c COG1266R II.C.5 nonessential integral membrane protein KEEP 754410..754684 754410 754684 I NA NA IG670_Rv0658c-Rv0659c KEEP 754685..754993 754685 754993 - 102 15607799 - Rv0659c COG2337T V nonessential hypothetical protein KEEP 754980..755225 754980 755225 - 81 15607800 - Rv0660c - V nonessential hypothetical protein KEEP 755226..755334 755226 755258 I NA NA IG672_Rv0660c-Rv0661c KEEP 755226..755334 755259 755331 I NA NA IG672_Rv0660c-Rv0661c Marin et al 2022 + homoplasy analysis DISCARD 755226..755334 755332 755334 I NA NA IG672_Rv0660c-Rv0661c KEEP 755335..755772 755335 755772 - 145 15607801 - Rv0661c - V nonessential hypothetical protein KEEP 755769..756137 755769 756137 - 122 15607802 - Rv0662c - V nonessential hypothetical protein KEEP 756137..758500 756137 758500 + 787 15607803 atsD Rv0663 COG3119P I.C.5 nonessential arylsulfatase AtsD KEEP 758501..758531 758501 758531 I NA NA IG675_Rv0663-Rv0664 KEEP 758532..758804 758532 758804 + 90 15607804 - Rv0664 - VI nonessential hypothetical protein KEEP 758801..759139 758801 759139 + 112 15607805 - Rv0665 - V nonessential hypothetical protein KEEP 759136..759309 759136 759309 + 57 15607806 - Rv0666 - II.C.5 essential hypothetical protein KEEP 759310..759806 759310 759806 I NA NA IG678_Rv0666-Rv0667 KEEP 759807..763325 759807 763325 + 1172 15607807 rpoB Rv0667 COG0085K II.A.7 DR-rif essential DNA-directed RNA polymerase subunit beta KEEP 763326..763369 763326 763369 I NA NA IG679_Rv0667-Rv0668 KEEP 763370..767320 763370 767320 + 1316 15607808 rpoC Rv0668 COG0086K II.A.7 essential DNA-directed RNA polymerase subunit beta' KEEP 767321..767683 767321 767364 I NA NA IG680_Rv0668-Rv0669c KEEP 767321..767683 767365 767371 I NA NA IG680_Rv0668-Rv0669c Only Marin et al 2022 KEEP 767321..767683 767372 767683 I NA NA IG680_Rv0668-Rv0669c KEEP 767684..769597 767684 769597 - 637 15607809 - Rv0669c - IV.I nonessential hydrolase KEEP 769598..769791 769598 769791 I NA NA IG681_Rv0669c-Rv0670 KEEP 769792..770550 769792 770550 + 252 15607810 end Rv0670 COG0648L II.B.2 essential endonuclease IV KEEP 770551..770581 770551 770581 I NA NA IG682_Rv0670-Rv0671 KEEP 770582..771424 770582 771424 + 280 15607811 lpqP Rv0671 COG3509Q II.C.1 nonessential lipoprotein LpqP KEEP 771425..771483 771425 771483 I NA NA IG683_Rv0671-Rv0672 KEEP 771484..773112 771484 773112 + 542 15607812 fadE8 Rv0672 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE8 KEEP 773113..773122 773113 773122 I NA NA IG684_Rv0672-Rv0673 KEEP 773123..774061 773123 774061 + 312 15607813 echA4 Rv0673 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 774062..774063 774062 774063 I NA NA IG685_Rv0673-Rv0674 KEEP 774064..774786 774064 774786 + 240 15607814 - Rv0674 COG3327K V essential hypothetical protein KEEP 774783..775574 774783 775574 + 263 57116767 echA5 Rv0675 COG1024I I.A.3 essential enoyl-CoA hydratase KEEP 775575..775585 775575 775585 I NA NA IG687_Rv0675-Rv0676c KEEP 775586..778480 775586 776714 - 964 15607816 mmpL5 Rv0676c COG2409R II.C.4 nonessential transmembrane transport protein MmpL5 KEEP 775586..778480 776715 776768 - 964 15607816 mmpL5 Rv0676c COG2409R II.C.4 nonessential transmembrane transport protein MmpL5 Only Marin et al 2022 KEEP 775586..778480 776769 778480 - 964 15607816 mmpL5 Rv0676c COG2409R II.C.4 nonessential transmembrane transport protein MmpL5 KEEP 778477..778905 778477 778905 - 142 15607817 mmpS5 Rv0677c COG1138O II.C.4 nonessential hypothetical protein KEEP 778906..778989 778906 778989 I NA NA IG689_Rv0677c-Rv0678 KEEP 778990..779487 778990 779487 + 165 15607818 - Rv0678 - V nonessential hypothetical protein KEEP 779488..779542 779488 779542 I NA NA IG690_Rv0678-Rv0679c KEEP 779543..780040 779543 780040 - 165 15607819 - Rv0679c - V nonessential putative threonine rich protein KEEP 780042..780416 780042 780416 - 124 15607820 - Rv0680c - II.C.5 nonessential transmembrane protein KEEP 780417..780720 780417 780720 I NA NA IG692_Rv0680c-Rv0681 KEEP 780721..781311 780721 781311 + 196 15607821 - Rv0681 COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 781312..781559 781312 781559 I NA NA IG693_Rv0681-Rv0682 KEEP 781560..781934 781560 781934 + 124 15607822 rpsL Rv0682 COG0048J II.A.1 DR-sm essential 30S ribosomal protein S12 KEEP 781934..782404 781934 782404 + 156 15607823 rpsG Rv0683 COG0049J II.A.1 essential 30S ribosomal protein S7 KEEP 782405..782484 782405 782484 I NA NA IG695_Rv0683-Rv0684 KEEP 782485..784590 782485 784590 + 701 57116768 fusA1 Rv0684 COG0480J II.A.6 essential elongation factor G KEEP 784591..784820 784591 784820 I NA NA IG696_Rv0684-Rv0685 KEEP 784821..786011 784821 786011 + 396 15607825 tuf Rv0685 COG0050J II.A.6 essential elongation factor Tu KEEP 786012..786148 786012 786024 I NA NA IG697_Rv0685-Rv0686 KEEP 786012..786148 786025 786081 I NA NA IG697_Rv0685-Rv0686 Only Marin et al 2022 KEEP 786012..786148 786082 786148 I NA NA IG697_Rv0685-Rv0686 KEEP 786149..786946 786149 786946 + 265 15607826 - Rv0686 - II.C.5 nonessential hypothetical protein KEEP 786947..787098 786947 787098 I NA NA IG698_Rv0686-Rv0687 KEEP 787099..787926 787099 787926 + 275 15607827 fabG Rv0687 COG1028IQR VI essential 3-ketoacyl-(acyl-carrier-protein) reductase KEEP 787927..787939 787927 787939 I NA NA IG699_Rv0687-Rv0688 KEEP 787940..789160 787940 789160 + 406 15607828 - Rv0688 COG0446R I.B.7 nonessential putative ferredoxin reductase KEEP 789157..789411 789157 789411 - 84 15607829 - Rv0689c - VI nonessential hypothetical protein KEEP 789412..790023 789412 790023 I NA NA IG701_Rv0689c-Rv0690c KEEP 790024..791073 790024 791073 - 349 15607830 - Rv0690c COG4427S V nonessential hypothetical protein KEEP 791070..791666 791070 791666 - 198 15607831 - Rv0691c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 791667..791830 791667 791830 I NA NA IG703_Rv0691c-Rv0692 KEEP 791831..792160 791831 792160 + 109 15607832 - Rv0692 - V nonessential hypothetical protein KEEP 792157..793332 792157 793332 + 391 15607833 pqqE Rv0693 COG0535R I.G.11 nonessential coenzyme PQQ synthesis protein E KEEP 793333..793334 793333 793334 I NA NA IG705_Rv0693-Rv0694 KEEP 793335..794525 793335 794525 + 396 15607834 lldD1 Rv0694 COG1304C I.B.6a nonessential L-lactate dehydrogenase (cytochrome) LldD1 KEEP 794526..794714 794526 794714 I NA NA IG706_Rv0694-Rv0695 KEEP 794715..795470 794715 795467 + 251 15607835 - Rv0695 COG1402R V nonessential hypothetical protein KEEP 794715..795470 795468 795470 + 251 15607835 - Rv0695 COG1402R V nonessential hypothetical protein Only Marin et al 2022 KEEP 795471..795518 795471 795518 I NA NA IG707_Rv0695-Rv0696 Only Marin et al 2022 KEEP 795519..796931 795519 795527 + 470 15607836 - Rv0696 COG0463M II.C.5 nonessential membrane sugar transferase Only Marin et al 2022 KEEP 795519..796931 795528 796931 + 470 15607836 - Rv0696 COG0463M II.C.5 nonessential membrane sugar transferase KEEP 796933..798372 796933 798372 + 479 15607837 - Rv0697 COG2303E VI essential dehydrogenase KEEP 798373..798832 798373 798662 I NA NA IG709_Rv0697-Rv0698 KEEP 798373..798832 798663 798739 I NA NA IG709_Rv0697-Rv0698 Only Marin et al 2022 KEEP 798373..798832 798740 798832 I NA NA IG709_Rv0697-Rv0698 KEEP 798833..799444 798833 798997 + 203 15607838 - Rv0698 - V nonessential hypothetical protein KEEP 798833..799444 798998 799069 + 203 15607838 - Rv0698 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 798833..799444 799070 799444 + 203 15607838 - Rv0698 - V nonessential hypothetical protein KEEP 799445..799628 799445 799628 I NA NA IG710_Rv0698-Rv0699 KEEP 799629..799850 799629 799850 + 73 15607839 - Rv0699 - VI nonessential hypothetical protein KEEP 799851..800486 799851 800486 I NA NA IG711_Rv0699-Rv0700 KEEP 800487..800792 800487 800792 + 101 15607840 rpsJ Rv0700 COG0051J II.A.1 essential 30S ribosomal protein S10 KEEP 800793..800808 800793 800808 I NA NA IG712_Rv0700-Rv0701 KEEP 800809..801462 800809 801462 + 217 15607841 rplC Rv0701 COG0087J II.A.1 essential 50S ribosomal protein L3 KEEP 801462..802133 801462 802133 + 223 15607842 rplD Rv0702 COG0088J II.A.1 essential 50S ribosomal protein L4 KEEP 802133..802435 802133 802435 + 100 15607843 rplW Rv0703 COG0089J II.A.1 essential 50S ribosomal protein L23 KEEP 802436..802527 802436 802527 I NA NA IG715_Rv0703-Rv0704 KEEP 802528..803370 802528 803370 + 280 15607844 rplB Rv0704 COG0090J II.A.1 essential 50S ribosomal protein L2 KEEP 803371..803410 803371 803410 I NA NA IG716_Rv0704-Rv0705 KEEP 803411..803692 803411 803692 + 93 15607845 rpsS Rv0705 COG0185J II.A.1 essential 30S ribosomal protein S19 KEEP 803689..804282 803689 804282 + 197 15607846 rplV Rv0706 COG0091J II.A.1 essential 50S ribosomal protein L22 KEEP 804282..805106 804282 805106 + 274 15607847 rpsC Rv0707 COG0092J II.A.1 essential 30S ribosomal protein S3 KEEP 805107..805109 805107 805109 I NA NA IG719_Rv0707-Rv0708 KEEP 805110..805526 805110 805526 + 138 15607848 rplP Rv0708 COG0197J II.A.1 essential 50S ribosomal protein L16 KEEP 805526..805759 805526 805759 + 77 15607849 rpmC Rv0709 COG0255J II.A.1 essential 50S ribosomal protein L29 KEEP 805756..806166 805756 806166 + 136 15607850 rpsQ Rv0710 COG0186J II.A.1 essential 30S ribosomal protein S17 KEEP 806167..806334 806167 806192 I NA NA IG722_Rv0710-Rv0711 KEEP 806167..806334 806193 806199 I NA NA IG722_Rv0710-Rv0711 Only Marin et al 2022 KEEP 806167..806334 806200 806201 I NA NA IG722_Rv0710-Rv0711 KEEP 806167..806334 806202 806219 I NA NA IG722_Rv0710-Rv0711 Only Marin et al 2022 KEEP 806167..806334 806220 806334 I NA NA IG722_Rv0710-Rv0711 KEEP 806335..808698 806335 808698 + 787 15607851 atsA Rv0711 COG3119P I.C.5 nonessential arylsulfatase AtsA KEEP 808699..808745 808699 808745 I NA NA IG723_Rv0711-Rv0712 KEEP 808746..809645 808746 809645 + 299 15607852 - Rv0712 COG1262S V nonessential hypothetical protein KEEP 809646..809945 809646 809945 I NA NA IG724_Rv0712-Rv0713 KEEP 809946..810887 809946 810887 + 313 15607853 - Rv0713 - II.C.5 nonessential transmembrane protein KEEP 810888..811372 810888 811372 I NA NA IG725_Rv0713-Rv0714 KEEP 811373..811741 811373 811741 + 122 15607854 rplN Rv0714 COG0093J II.A.1 essential 50S ribosomal protein L14 KEEP 811742..812059 811742 812059 + 105 15607855 rplX Rv0715 COG0198J II.A.1 essential 50S ribosomal protein L24 KEEP 812059..812622 812059 812622 + 187 15607856 rplE Rv0716 COG0094J II.A.1 essential 50S ribosomal protein L5 KEEP 812623..812626 812623 812626 I NA NA IG728_Rv0716-Rv0717 KEEP 812627..812812 812627 812812 + 61 57116769 rpsN Rv0717 COG0199J II.A.1 nonessential 30S ribosomal protein S14 KEEP 812813..812975 812813 812847 I NA NA IG729_Rv0717-Rv0718 KEEP 812813..812975 812848 812898 I NA NA IG729_Rv0717-Rv0718 Only Marin et al 2022 KEEP 812813..812975 812899 812975 I NA NA IG729_Rv0717-Rv0718 KEEP 812976..813374 812976 813374 + 132 15607858 rpsH Rv0718 COG0096J II.A.1 essential 30S ribosomal protein S8 KEEP 813375..813397 813375 813397 I NA NA IG730_Rv0718-Rv0719 KEEP 813398..813937 813398 813937 + 179 15607859 rplF Rv0719 COG0097J II.A.1 essential 50S ribosomal protein L6 KEEP 813938..813939 813938 813939 I NA NA IG731_Rv0719-Rv0720 KEEP 813940..814308 813940 814308 + 122 15607860 rplR Rv0720 COG0256J II.A.1 essential 50S ribosomal protein L18 KEEP 814309..814327 814309 814327 I NA NA IG732_Rv0720-Rv0721 KEEP 814328..814990 814328 814990 + 220 15607861 rpsE Rv0721 COG0098J II.A.1 essential 30S ribosomal protein S5 KEEP 814991..814992 814991 814992 I NA NA IG733_Rv0721-Rv0722 KEEP 814993..815190 814993 815190 + 65 15607862 rpmD Rv0722 COG1841J II.A.1 essential 50S ribosomal protein L30 KEEP 815190..815630 815190 815630 + 146 15607863 rplO Rv0723 COG0200J II.A.1 nonessential 50S ribosomal protein L15 KEEP 815631..815662 815631 815662 I NA NA IG735_Rv0723-Rv0724 KEEP 815663..817534 815663 817534 + 623 15607864 sppA Rv0724 COG0616OU II.B.3 nonessential protease IV SppA KEEP 817531..817866 817531 817866 - 111 57116770 - Rv0724A - V nonessential hypothetical protein KEEP 817539..818444 817539 818307 - 301 15607865 - Rv0725c COG3315Q V nonessential hypothetical protein KEEP 817539..818444 818308 818358 - 301 15607865 - Rv0725c COG3315Q V nonessential hypothetical protein Only Marin et al 2022 KEEP 817539..818444 818359 818444 - 301 15607865 - Rv0725c COG3315Q V nonessential hypothetical protein KEEP 818445..818536 818445 818536 I NA NA IG738_Rv0725c-Rv0726c KEEP 818537..819640 818537 819640 - 367 15607866 - Rv0726c COG3315Q V nonessential hypothetical protein KEEP 819641..819842 819641 819842 I NA NA IG739_Rv0726c-Rv0727c KEEP 819843..820499 819843 820499 - 218 15607867 fucA Rv0727c COG0235G I.A.1 nonessential L-fuculose-phosphate aldolase KEEP 820496..821476 820496 821476 - 326 15607868 serA2 Rv0728c COG0111HE I.B.7 nonessential D-3-phosphoglycerate dehydrogenase KEEP 821477..821506 821477 821506 I NA NA IG741_Rv0728c-Rv0729 KEEP 821507..822853 821507 822853 + 448 15607869 xylB Rv0729 COG1070G I.A.1 nonessential D-xylulose kinase XylB KEEP 822854..822865 822854 822865 I NA NA IG742_Rv0729-Rv0730 KEEP 822866..823594 822866 823594 + 242 15607870 - Rv0730 - V nonessential hypothetical protein KEEP 823595..823682 823595 823682 I NA NA IG743_Rv0730-Rv0731c KEEP 823683..824639 823683 824639 - 318 15607871 - Rv0731c COG3315Q V nonessential hypothetical protein KEEP 824640..824799 824640 824799 I NA NA IG744_Rv0731c-Rv0732 KEEP 824800..826125 824800 826125 + 441 15607872 secY Rv0732 COG0201U III.D essential preprotein translocase subunit SecY KEEP 826122..826667 826122 826667 + 181 15607873 adk Rv0733 COG0563F I.F.5 nonessential adenylate kinase KEEP 826668..826669 826668 826669 I NA NA IG746_Rv0733-Rv0734 KEEP 826670..827470 826670 827470 + 266 57116771 mapA Rv0734 COG0024J II.B.3 nonessential methionine aminopeptidase KEEP 827471..827542 827471 827542 I NA NA IG747_Rv0734-Rv0735 KEEP 827543..828076 827543 828076 + 177 15607875 sigL Rv0735 COG1595K II.A.7 nonessential RNA polymerase sigma factor SigL KEEP 828077..828139 828077 828139 I NA NA IG748_Rv0735-Rv0736 KEEP 828140..828892 828140 828892 + 250 15607876 - Rv0736 COG5662K II.C.4 essential hypothetical protein KEEP 828893..829206 828893 829206 I NA NA IG749_Rv0736-Rv0737 KEEP 829207..829704 829207 829701 + 165 15607877 - Rv0737 COG1846K I.J.1 nonessential transcriptional regulatory protein KEEP 829207..829704 829702 829704 + 165 15607877 - Rv0737 COG1846K I.J.1 nonessential transcriptional regulatory protein Only Marin et al 2022 KEEP 829705..830061 829705 829773 I NA NA IG750_Rv0737-Rv0738 Marin et al 2022 + homoplasy analysis DISCARD 829705..830061 829774 830061 I NA NA IG750_Rv0737-Rv0738 KEEP 830062..830610 830062 830610 + 182 15607878 - Rv0738 - V nonessential hypothetical protein KEEP 830611..830854 830611 830628 I NA NA IG751_Rv0738-Rv0739 KEEP 830611..830854 830629 830685 I NA NA IG751_Rv0738-Rv0739 Only Marin et al 2022 KEEP 830611..830854 830686 830711 I NA NA IG751_Rv0738-Rv0739 KEEP 830611..830854 830712 830765 I NA NA IG751_Rv0738-Rv0739 Only Marin et al 2022 KEEP 830611..830854 830766 830854 I NA NA IG751_Rv0738-Rv0739 KEEP 830855..831661 830855 831187 + 268 15607879 - Rv0739 - V nonessential hypothetical protein KEEP 830855..831661 831188 831263 + 268 15607879 - Rv0739 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 830855..831661 831264 831661 + 268 15607879 - Rv0739 - V nonessential hypothetical protein KEEP 831662..831775 831662 831775 I NA NA IG752_Rv0739-Rv0740 KEEP 831776..832303 831776 831964 + 175 15607880 - Rv0740 - V nonessential hypothetical protein KEEP 831776..832303 831965 832028 + 175 15607880 - Rv0740 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 831776..832303 832029 832082 + 175 15607880 - Rv0740 - V nonessential hypothetical protein KEEP 831776..832303 832083 832303 + 175 15607880 - Rv0740 - V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 832304..832533 832304 832362 I NA NA IG753_Rv0740-Rv0741 Annotation + Marin et al 2022 DISCARD 832304..832533 832363 832533 I NA NA IG753_Rv0740-Rv0741 KEEP 832534..832848 832534 832653 + 104 15607881 - Rv0741 COG3464L IV.B.1 phage nonessential transposase KEEP 832534..832848 832654 832758 + 104 15607881 - Rv0741 COG3464L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 832534..832848 832759 832848 + 104 15607881 - Rv0741 COG3464L IV.B.1 phage nonessential transposase KEEP 832849..832980 832849 832980 I NA NA IG754_Rv0741-Rv0742 KEEP 832981..833508 832981 833508 + 175 57116772 PE_PGRS8 Rv0742 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 833509..833885 833509 833513 I NA NA IG755_Rv0742-Rv0743c KEEP 833509..833885 833514 833517 I NA NA IG755_Rv0742-Rv0743c Annotation + Marin et al 2022 DISCARD 833509..833885 833518 833528 I NA NA IG755_Rv0742-Rv0743c KEEP 833509..833885 833529 833539 I NA NA IG755_Rv0742-Rv0743c Annotation + Marin et al 2022 DISCARD 833509..833885 833540 833885 I NA NA IG755_Rv0742-Rv0743c KEEP 833886..834443 833886 834443 - 185 15607883 - Rv0743c - VI nonessential hypothetical protein KEEP 834440..834946 834440 834946 - 168 15607884 - Rv0744c - I.J.1 essential transcriptional regulatory protein KEEP 834947..835153 834947 835079 I NA NA IG757_Rv0744c-Rv0745 KEEP 834947..835153 835080 835153 I NA NA IG757_Rv0744c-Rv0745 Only Marin et al 2022 KEEP 835154..835681 835154 835203 + 175 15607885 - Rv0745 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 835154..835681 835204 835404 + 175 15607885 - Rv0745 - V nonessential hypothetical protein KEEP 835154..835681 835405 835458 + 175 15607885 - Rv0745 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 835154..835681 835459 835681 + 175 15607885 - Rv0745 - V nonessential hypothetical protein KEEP 835682..835700 835682 835700 I NA NA IG758_Rv0745-Rv0746 KEEP 835701..838052 835701 838052 + 783 57116773 PE_PGRS9 Rv0746 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 838053..838450 838053 838450 I NA NA IG759_Rv0746-Rv0747 repeat KEEP 838451..840856 838451 840856 + 801 57116774 PE_PGRS10 Rv0747 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 840857..840946 840857 840946 I NA NA IG760_Rv0747-Rv0748 KEEP 840947..841204 840947 840958 + 85 15607888 - Rv0748 - V nonessential hypothetical protein KEEP 840947..841204 840959 841073 + 85 15607888 - Rv0748 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 840947..841204 841074 841141 + 85 15607888 - Rv0748 - V nonessential hypothetical protein KEEP 840947..841204 841142 841204 + 85 15607888 - Rv0748 - V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 841205..841227 841205 841208 I NA NA IG761_Rv0748-Rv0749 Only Marin et al 2022 KEEP 841205..841227 841209 841223 I NA NA IG761_Rv0748-Rv0749 KEEP 841205..841227 841224 841227 I NA NA IG761_Rv0748-Rv0749 Only Marin et al 2022 KEEP 841228..841656 841228 841656 + 142 15607889 - Rv0749 - V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 841657..841736 841657 841666 I NA NA IG762_Rv0749-Rv0749A Only Marin et al 2022 KEEP 841657..841736 841667 841736 I NA NA IG762_Rv0749-Rv0749A KEEP 841737..841874 841737 841874 - 45 57116775 - Rv0749A - VI nonessential hypothetical protein KEEP 841875..842032 841875 841940 I NA NA IG763_Rv0749A-Rv0750 KEEP 841875..842032 841941 842016 I NA NA IG763_Rv0749A-Rv0750 Only Marin et al 2022 KEEP 841875..842032 842017 842032 I NA NA IG763_Rv0749A-Rv0750 KEEP 842033..842278 842033 842057 + 81 15607890 - Rv0750 - V nonessential hypothetical protein KEEP 842033..842278 842058 842278 + 81 15607890 - Rv0750 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 842279..842346 842279 842346 I NA NA IG764_Rv0750-Rv0751c Only Marin et al 2022 KEEP 842347..843231 842347 842470 - 294 15607891 mmsB Rv0751c COG2084I I.A.2 nonessential 3-hydroxyisobutyrate dehydrogenase MmsB Only Marin et al 2022 KEEP 842347..843231 842471 843231 - 294 15607891 mmsB Rv0751c COG2084I I.A.2 nonessential 3-hydroxyisobutyrate dehydrogenase MmsB KEEP 843232..843241 843232 843241 I NA NA IG765_Rv0751c-Rv0752c KEEP 843242..844414 843242 844414 - 390 15607892 fadE9 Rv0752c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE9 KEEP 844415..844420 844415 844420 I NA NA IG766_Rv0752c-Rv0753c KEEP 844421..845953 844421 844883 - 510 15607893 mmsA Rv0753c COG1012C I.A.2 nonessential methylmalonate-semialdehyde dehydrogenase KEEP 844421..845953 844884 844888 - 510 15607893 mmsA Rv0753c COG1012C I.A.2 nonessential methylmalonate-semialdehyde dehydrogenase Only Marin et al 2022 KEEP 844421..845953 844889 845953 - 510 15607893 mmsA Rv0753c COG1012C I.A.2 nonessential methylmalonate-semialdehyde dehydrogenase KEEP 845954..846158 845954 846158 I NA NA IG767_Rv0753c-Rv0754 KEEP 846159..847913 846159 846902 + 584 57116776 PE_PGRS11 Rv0754 COG0406G IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 846159..847913 846903 846905 + 584 57116776 PE_PGRS11 Rv0754 COG0406G IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 846159..847913 846906 847913 + 584 57116776 PE_PGRS11 Rv0754 COG0406G IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 847914..848102 847914 848102 I NA NA IG768_Rv0754-Rv0755c repeat KEEP 848103..850040 848103 849911 - 645 57116777 PPE12 Rv0755c - IV.B.1 PE/PPE/PGRS essential PPE family protein KEEP 848103..850040 849912 849965 - 645 57116777 PPE12 Rv0755c - IV.B.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 848103..850040 849966 850040 - 645 57116777 PPE12 Rv0755c - IV.B.1 PE/PPE/PGRS essential PPE family protein KEEP 850041..850341 850041 850341 I NA NA IG769_Rv0755c-Rv0755A repeat KEEP 850342..850527 850342 850527 - 61 57116778 - Rv0755A COG3415L IV.C.1 phage nonessential transposase KEEP 850528..850740 850528 850740 I NA NA IG770_Rv0755A-Rv0756c KEEP 850741..851466 850741 851466 - 241 15607896 - Rv0756c COG0108H VI nonessential hypothetical protein KEEP 851467..851607 851467 851607 I NA NA IG771_Rv0756c-Rv0757 KEEP 851608..852351 851608 852351 + 247 15607897 phoP Rv0757 COG0745TK I.J.2 nonessential two component system response transcriptional positive regulator PHOP KEEP 852352..852395 852352 852395 I NA NA IG772_Rv0757-Rv0758 KEEP 852396..853853 852396 853853 + 485 15607898 phoR Rv0758 COG0642T I.J.2 nonessential two component system response sensor kinase membrane associated PHOR KEEP 853825..854157 853825 854157 - 110 15607899 - Rv0759c COG0537FGR V nonessential hypothetical protein KEEP 854158..854266 854158 854266 I NA NA IG774_Rv0759c-Rv0760c KEEP 854267..854686 854267 854686 - 139 15607900 - Rv0760c - V nonessential hypothetical protein KEEP 854687..854698 854687 854698 I NA NA IG775_Rv0760c-Rv0761c KEEP 854699..855826 854699 855826 - 375 57116779 adhB Rv0761c COG1062C I.B.7 nonessential zinc-containing alcohol dehydrogenase NAD dependent ADHB KEEP 855827..855924 855827 855924 I NA NA IG776_Rv0761c-Rv0762c KEEP 855925..856470 855925 856470 - 181 15607902 - Rv0762c - V nonessential hypothetical protein KEEP 856471..856472 856471 856472 I NA NA IG777_Rv0762c-Rv0763c KEEP 856473..856679 856473 856679 - 68 15607903 - Rv0763c COG1141C VII nonessential ferredoxin KEEP 856680..856681 856680 856681 I NA NA IG778_Rv0763c-Rv0764c KEEP 856682..858037 856682 858037 - 451 15607904 cyp51 Rv0764c COG2124Q IV.F nonessential cytochrome P450 sterol 14-alpha demethylase KEEP 858037..858864 858037 858864 - 275 15607905 - Rv0765c COG1028IQR I.B.7 nonessential short chain dehydrogenase KEEP 858864..860072 858864 860072 - 402 15607906 cyp123 Rv0766c COG2124Q IV.F nonessential cytochrome P450 123 KEEP 860069..860710 860069 860710 - 213 15607907 - Rv0767c - V nonessential hypothetical protein KEEP 860711..860911 860711 860911 I NA NA IG782_Rv0767c-Rv0768 KEEP 860912..862381 860912 862381 + 489 15607908 aldA Rv0768 COG1012C I.B.7 nonessential aldehyde dehydrogenase NAD dependent AldA KEEP 862382..862411 862382 862411 I NA NA IG783_Rv0768-Rv0769 KEEP 862412..863158 862412 863158 + 248 15607909 - Rv0769 COG1028IQR VI nonessential short chain dehydrogenase KEEP 863159..863255 863159 863184 I NA NA IG784_Rv0769-Rv0770 KEEP 863159..863255 863185 863255 I NA NA IG784_Rv0769-Rv0770 Only Marin et al 2022 KEEP 863256..864143 863256 863260 + 295 15607910 - Rv0770 COG2084I VI nonessential dehydrogenase/reductase Only Marin et al 2022 KEEP 863256..864143 863261 864143 + 295 15607910 - Rv0770 COG2084I VI nonessential dehydrogenase/reductase KEEP 864140..864574 864140 864574 + 144 15607911 - Rv0771 COG0599S II.B.6 nonessential 4-carboxymuconolactone decarboxylase KEEP 864575..864585 864575 864585 I NA NA IG786_Rv0771-Rv0772 KEEP 864586..865854 864586 865854 + 422 15607912 purD Rv0772 COG0151F I.F.1 essential phosphoribosylamine--glycine ligase KEEP 865851..867389 865851 867389 - 512 15607913 ggtA Rv0773c COG0405E I.G.10 nonessential bifunctional cephalosporin acylase/gamma-glutamyltranspeptidase KEEP 867390..867439 867390 867439 I NA NA IG788_Rv0773c-Rv0774c KEEP 867440..868351 867440 868351 - 303 57116780 - Rv0774c COG0627R VI nonessential hypothetical protein KEEP 868352..868406 868352 868406 I NA NA IG789_Rv0774c-Rv0775 KEEP 868407..869030 868407 869030 + 207 15607915 - Rv0775 COG3226S V nonessential hypothetical protein KEEP 868984..869763 868984 869763 - 259 15607916 - Rv0776c COG4328S V nonessential hypothetical protein KEEP 869764..870007 869764 870007 I NA NA IG791_Rv0776c-Rv0777 KEEP 870008..871426 870008 871426 + 472 15607917 purB Rv0777 COG0015F I.F.1 nonessential adenylosuccinate lyase KEEP 871427..871430 871427 871430 I NA NA IG792_Rv0777-Rv0778 KEEP 871431..872675 871431 872675 + 414 15607918 cyp126 Rv0778 COG2124Q IV.F nonessential cytochrome P450 126 KEEP 872672..873292 872672 873292 - 206 15607919 - Rv0779c COG0841V II.C.5 nonessential transmembrane protein KEEP 873293..873342 873293 873342 I NA NA IG794_Rv0779c-Rv0780 KEEP 873343..874236 873343 874236 + 297 15607920 hemH Rv0780 COG0152F I.F.1 essential phosphoribosylaminoimidazole-succinocarboxamide synthase KEEP 874233..874943 874233 874943 + 236 57116781 ptrBa Rv0781 COG1770E II.B.3 essential oligopeptidase B KEEP 874732..876390 874732 876390 + 552 57116782 ptrBb Rv0782 COG1770E II.B.3 nonessential oligopeptidase B KEEP 876391..876817 876391 876817 I NA NA IG797_Rv0782-Rv0783c KEEP 876818..878440 876818 878440 - 540 15607923 emrB Rv0783c COG0477GEPR III.A.6 nonessential multidrug resistance integral membrane efflux protein EmrB KEEP 878441..878637 878441 878637 I NA NA IG798_Rv0783c-Rv0784 KEEP 878638..879324 878638 879324 + 228 15607924 - Rv0784 COG3233R V nonessential hypothetical protein KEEP 879325..879339 879325 879339 I NA NA IG799_Rv0784-Rv0785 KEEP 879340..881040 879340 881040 + 566 15607925 - Rv0785 COG3573R V nonessential putative FAD-binding dehydrogenase KEEP 881041..881074 881041 881074 I NA NA IG800_Rv0785-Rv0786c KEEP 881075..881464 881075 881464 - 129 15607926 - Rv0786c COG2220R V nonessential hypothetical protein KEEP 881459..882418 881459 882418 + 319 15607927 - Rv0787 COG0458EF VI nonessential hypothetical protein KEEP 882419..882523 882419 882523 I NA NA IG802_Rv0787-Rv0787A KEEP 882524..882763 882524 882763 + 79 57116783 - Rv0787A COG1828F V nonessential phosphoribosylformylglycinamidine synthase subunit PurS KEEP 882760..883434 882760 883434 + 224 15607928 purQ Rv0788 COG0047F I.F.1 essential phosphoribosylformylglycinamidine synthase subunit I KEEP 883435..883450 883435 883450 I NA NA IG804_Rv0788-Rv0789c KEEP 883451..884050 883451 884050 - 199 15607929 - Rv0789c - VI nonessential hypothetical protein KEEP 884051..884071 884051 884071 I NA NA IG805_Rv0789c-Rv0790c KEEP 884072..884800 884072 884800 - 242 15607930 - Rv0790c COG1305E VI nonessential hypothetical protein KEEP 884797..885840 884797 885840 - 347 15607931 - Rv0791c COG2141C V nonessential hypothetical protein KEEP 885837..886646 885837 886646 - 269 15607932 - Rv0792c COG2188K I.J.1 nonessential GntR family transcriptional regulator KEEP 886647..886718 886647 886718 I NA NA IG808_Rv0792c-Rv0793 KEEP 886719..887024 886719 887024 + 101 15607933 - Rv0793 COG1359S V nonessential hypothetical protein KEEP 887025..887136 887025 887136 I NA NA IG809_Rv0793-Rv0794c KEEP 887137..888636 887137 888636 - 499 57116784 - Rv0794c COG1249C I.B.3 nonessential oxidoreductase KEEP 888637..889071 888637 888761 I NA NA IG810_Rv0794c-Rv0795 Annotation + homoplasy analysis DISCARD 888637..889071 888762 889071 I NA NA IG810_Rv0794c-Rv0795 Annotation + Marin et al 2022 DISCARD 889072..889398 889072 889398 + 108 15607935 - Rv0795 COG2963L IV.B.1 phage nonessential transposase IS6110 Annotation + Marin et al 2022 DISCARD 889395..890333 889395 890333 + 312 15607936 - Rv0796 COG2801L IV.B.1 phage nonessential transposase IS6110 Annotation + Marin et al 2022 DISCARD 890334..890387 890334 890387 I NA NA IG812_Rv0796-Rv0797 repeat Annotation + Marin et al 2022 DISCARD 890388..891482 890388 891466 + 364 15607937 - Rv0797 COG3547L IV.B.1 phage nonessential IS1547 transposase Annotation + Marin et al 2022 DISCARD 890388..891482 891467 891482 + 364 15607937 - Rv0797 COG3547L IV.B.1 phage nonessential IS1547 transposase KEEP 891472..892269 891472 892269 - 265 15607938 cfp29 Rv0798c COG1659S VI essential 29 kDa antigen CFP29 KEEP 892266..893273 892266 893273 - 335 15607939 - Rv0799c COG2837P V nonessential hypothetical protein KEEP 893274..893317 893274 893317 I NA NA IG815_Rv0799c-Rv0800 KEEP 893318..894619 893318 894619 + 433 15607940 pepC Rv0800 COG1362E II.B.3 nonessential putative aminopeptidase 2 KEEP 894620..894630 894620 894630 I NA NA IG816_Rv0800-Rv0801 KEEP 894631..894978 894631 894978 + 115 15607941 - Rv0801 - V nonessential hypothetical protein KEEP 894972..895628 894972 895628 - 218 15607942 - Rv0802c COG1670J IV.D nonessential hypothetical protein KEEP 895629..895819 895629 895819 I NA NA IG818_Rv0802c-Rv0803 KEEP 895820..898084 895820 898084 + 754 15607943 purL Rv0803 COG0046F I.F.1 essential phosphoribosylformylglycinamidine synthase II KEEP 898081..898710 898081 898710 + 209 15607944 - Rv0804 COG1266R V nonessential hypothetical protein KEEP 898711..898830 898711 898830 I NA NA IG820_Rv0804-Rv0805 KEEP 898831..899787 898831 899787 + 318 15607945 - Rv0805 COG1409R V nonessential hypothetical protein KEEP 899732..901330 899732 901330 - 532 15607946 cpsY Rv0806c - II.C.2 nonessential UDP-glucose-4-epimerase CpsY KEEP 901331..901634 901331 901634 I NA NA IG822_Rv0806c-Rv0807 KEEP 901635..902024 901635 902024 + 129 15607947 - Rv0807 - V nonessential hypothetical protein KEEP 902025..902110 902025 902110 I NA NA IG823_Rv0807-Rv0808 KEEP 902111..903694 902111 903694 + 527 15607948 purF Rv0808 COG0034F I.F.1 essential amidophosphoribosyltransferase KEEP 903695..903724 903695 903724 I NA NA IG824_Rv0808-Rv0809 KEEP 903725..904819 903725 904819 + 364 15607949 purM Rv0809 COG0150F I.F.1 nonessential phosphoribosylaminoimidazole synthetase KEEP 904820..904904 904820 904904 I NA NA IG825_Rv0809-Rv0810c KEEP 904905..905087 904905 905087 - 60 15607950 - Rv0810c - V nonessential hypothetical protein KEEP 905088..905233 905088 905233 I NA NA IG826_Rv0810c-Rv0811c KEEP 905234..906340 905234 906340 - 368 15607951 - Rv0811c COG0354R V essential hypothetical protein KEEP 906341..906422 906341 906422 I NA NA IG827_Rv0811c-Rv0812 KEEP 906423..907292 906423 907292 + 289 57116785 - Rv0812 COG0115EH I.G.2 nonessential 4-amino-4-deoxychorismate lyase KEEP 907293..907337 907293 907337 I NA NA IG828_Rv0812-Rv0813c KEEP 907338..908018 907338 908018 - 226 15607953 - Rv0813c - V nonessential hypothetical protein KEEP 908019..908180 908019 908175 I NA NA IG829_Rv0813c-Rv0814c KEEP 908019..908180 908176 908180 I NA NA IG829_Rv0813c-Rv0814c Only Marin et al 2022 KEEP 908181..908483 908181 908483 - 100 15607954 sseC2 Rv0814c - I.C.5 nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 908485..909318 908485 909318 - 277 15607955 cysA2 Rv0815c COG2897P I.D.3 nonessential thiosulfate sulfurtransferase CysA2 Only Marin et al 2022 KEEP 909319..909610 909319 909351 I NA NA IG831_Rv0815c-Rv0816c Only Marin et al 2022 KEEP 909319..909610 909352 909610 I NA NA IG831_Rv0815c-Rv0816c KEEP 909611..910033 909611 910033 - 140 15607956 thiX Rv0816c COG0526OC I.G.10 nonessential thioredoxin ThiX KEEP 910030..910842 910030 910842 - 270 15607957 - Rv0817c - VI essential hypothetical protein KEEP 910843..910971 910843 910971 I NA NA IG833_Rv0817c-Rv0818 KEEP 910972..911739 910972 911739 + 255 15607958 - Rv0818 COG0745TK I.J.2 nonessential transcriptional regulatory protein KEEP 911736..912683 911736 912683 + 315 15607959 - Rv0819 COG0456R V nonessential hypothetical protein KEEP 912684..912725 912684 912725 I NA NA IG835_Rv0819-Rv0820 KEEP 912726..913502 912726 913502 + 258 15607960 phoT Rv0820 COG1117P III.A.4 nonessential phosphate ABC transporter ATP-binding protein KEEP 913503..913557 913503 913557 I NA NA IG836_Rv0820-Rv0821c KEEP 913558..914199 913558 914199 - 213 15607961 phoY2 Rv0821c COG0704P III.A.4 nonessential phosphate transport regulator KEEP 914200..914256 914200 914256 I NA NA IG837_Rv0821c-Rv0822c KEEP 914257..916311 914257 916311 - 684 15607962 - Rv0822c COG1316K V nonessential hypothetical protein KEEP 916312..916476 916312 916476 I NA NA IG838_Rv0822c-Rv0823c KEEP 916477..917646 916477 917605 - 389 15607963 - Rv0823c COG0042J I.J.1 nonessential transcriptional regulatory protein KEEP 916477..917646 917606 917646 - 389 15607963 - Rv0823c COG0042J I.J.1 nonessential transcriptional regulatory protein Only Marin et al 2022 KEEP 917647..917733 917647 917733 I NA NA IG839_Rv0823c-Rv0824c Only Marin et al 2022 KEEP 917734..918750 917734 917740 - 338 57116786 desA1 Rv0824c - I.H.2 essential acyl-[acyl-carrier protein] desaturase Only Marin et al 2022 KEEP 917734..918750 917741 918750 - 338 57116786 desA1 Rv0824c - I.H.2 essential acyl-[acyl-carrier protein] desaturase KEEP 918751..918911 918751 918911 I NA NA IG840_Rv0824c-Rv0825c KEEP 918912..919553 918912 919553 - 213 15607965 - Rv0825c COG1309K V nonessential hypothetical protein KEEP 919554..919633 919554 919633 I NA NA IG841_Rv0825c-Rv0826 KEEP 919634..920689 919634 920689 + 351 15607966 - Rv0826 COG3662S V nonessential hypothetical protein KEEP 920690..920740 920690 920740 I NA NA IG842_Rv0826-Rv0827c KEEP 920741..921133 920741 921133 - 130 15607967 - Rv0827c COG0640K I.J.1 nonessential transcriptional regulatory protein KEEP 921134..921190 921134 921190 I NA NA IG843_Rv0827c-Rv0828c KEEP 921191..921613 921191 921572 - 140 15607968 - Rv0828c COG0590FJ VI nonessential deaminase KEEP 921191..921613 921573 921613 - 140 15607968 - Rv0828c COG0590FJ VI nonessential deaminase Only Marin et al 2022 KEEP 921575..921865 921575 921865 + 96 15607969 - Rv0829 COG0675L IV.B.1 nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 921866..921969 921866 921897 I NA NA IG845_Rv0829-Rv0830 Only Marin et al 2022 KEEP 921866..921969 921898 921969 I NA NA IG845_Rv0829-Rv0830 KEEP 921970..922875 921970 922875 + 301 15607970 - Rv0830 COG3315Q V nonessential hypothetical protein KEEP 922876..922893 922876 922893 I NA NA IG846_Rv0830-Rv0831c KEEP 922894..923709 922894 923709 - 271 15607971 - Rv0831c - V nonessential hypothetical protein KEEP 923710..924950 923710 924950 I NA NA IG847_Rv0831c-Rv0832 KEEP 924951..925364 924951 925069 + 137 57116787 PE_PGRS12 Rv0832 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 924951..925364 925070 925133 + 137 57116787 PE_PGRS12 Rv0832 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 924951..925364 925134 925261 + 137 57116787 PE_PGRS12 Rv0832 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 924951..925364 925262 925364 + 137 57116787 PE_PGRS12 Rv0832 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 925361..927610 925361 926393 + 749 57116788 PE_PGRS13 Rv0833 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 925361..927610 926394 926514 + 749 57116788 PE_PGRS13 Rv0833 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 925361..927610 926515 926596 + 749 57116788 PE_PGRS13 Rv0833 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 925361..927610 926597 926625 + 749 57116788 PE_PGRS13 Rv0833 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 925361..927610 926626 927518 + 749 57116788 PE_PGRS13 Rv0833 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 925361..927610 927519 927610 + 749 57116788 PE_PGRS13 Rv0833 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927611..927836 927611 927836 I NA NA IG849_Rv0833-Rv0834c repeat KEEP 927837..930485 927837 927889 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927837..930485 927890 927940 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 927837..930485 927941 928674 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927837..930485 928675 928791 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 927837..930485 928792 928867 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927837..930485 928868 928936 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 927837..930485 928937 929014 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927837..930485 929015 929360 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 927837..930485 929361 929366 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927837..930485 929367 929373 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 927837..930485 929374 929462 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927837..930485 929463 929470 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 927837..930485 929471 929475 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927837..930485 929476 929605 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 927837..930485 929606 929665 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 927837..930485 929666 929961 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 927837..930485 929962 930485 - 882 57116789 PE_PGRS14 Rv0834c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 930486..930952 930486 930952 I NA NA IG850_Rv0834c-Rv0835 KEEP 930953..931597 930953 931597 + 214 15607975 lpqQ Rv0835 - II.C.1 nonessential lipoprotein LpqQ KEEP 931598..932278 931598 932278 I NA NA IG851_Rv0835-Rv0836c KEEP 932279..932932 932279 932932 - 217 15607976 - Rv0836c COG4849S VI nonessential hypothetical protein KEEP 932933..933002 932933 933002 I NA NA IG852_Rv0836c-Rv0837c KEEP 933003..934031 933003 934031 - 342 15607977 - Rv0837c COG4861S VI nonessential hypothetical protein KEEP 934032..934719 934032 934719 I NA NA IG853_Rv0837c-Rv0838 KEEP 934720..935490 934720 935490 + 256 15607978 lpqR Rv0838 COG2173M II.C.1 nonessential lipoprotein LpqR KEEP 935491..935576 935491 935576 I NA NA IG854_Rv0838-Rv0839 KEEP 935577..936389 935577 936389 + 270 15607979 - Rv0839 COG0500QR V nonessential hypothetical protein KEEP 936390..936456 936390 936456 I NA NA IG855_Rv0839-Rv0840c KEEP 936457..937317 936457 937317 - 286 15607980 pip Rv0840c COG0596R II.B.3 nonessential proline iminopeptidase KEEP 937318..937592 937318 937592 I NA NA IG856_Rv0840c-Rv0841 KEEP 937593..937835 937593 937835 + 80 57116790 - Rv0841 COG0477GEPR II.C.5 nonessential transmembrane protein KEEP 937836..938111 937836 938111 I NA NA IG857_Rv0841-Rv0842 KEEP 938112..939404 938112 939404 + 430 15607982 - Rv0842 - II.C.5 nonessential integral membrane protein KEEP 939388..940392 939388 940392 + 334 15607983 - Rv0843 COG1071C VI nonessential dehydrogenase KEEP 940393..940455 940393 940455 I NA NA IG859_Rv0843-Rv0844c KEEP 940456..941106 940456 941106 - 216 15607984 narL Rv0844c COG2197TK I.J.2 nonessential nitrate/nitrite response transcriptional regulatory protein NarL KEEP 941107..941189 941107 941189 I NA NA IG860_Rv0844c-Rv0845 KEEP 941190..942467 941190 942467 + 425 15607985 - Rv0845 COG4585T I.J.2 nonessential two component sensor kinase KEEP 942468..942679 942468 942679 I NA NA IG861_Rv0845-Rv0846c KEEP 942680..944194 942680 944194 - 504 15607986 - Rv0846c COG2132Q VII nonessential oxidase KEEP 944195..944342 944195 944342 I NA NA IG862_Rv0846c-Rv0847 KEEP 944343..944735 944343 944735 + 130 15607987 lpqS Rv0847 - II.C.1 nonessential lipoprotein LpqS KEEP 944736..944937 944736 944937 I NA NA IG863_Rv0847-Rv0848 KEEP 944938..946056 944938 946056 + 372 57116791 cysK2 Rv0848 COG0031E I.D.3 nonessential cysteine synthase A CysK2 KEEP 946056..947315 946056 947315 + 419 15607989 - Rv0849 COG0477GEPR III.A.6 nonessential integral membrane transport protein KEEP 947312..947644 947312 947644 + 110 15607990 - Rv0850 COG3464L IV.B.1 phage nonessential transposase KEEP 947641..948468 947641 948468 - 275 15607991 - Rv0851c COG1028IQR VI nonessential short chain dehydrogenase KEEP 948469..948558 948469 948558 I NA NA IG867_Rv0851c-Rv0852 KEEP 948559..949395 948559 949395 + 278 15607992 fadD16 Rv0852 COG1022I I.A.3 nonessential fatty-acid-CoA ligase KEEP 949396..949435 949396 949435 I NA NA IG868_Rv0852-Rv0853c KEEP 949436..951118 949436 951118 - 560 15607993 pdc Rv0853c COG3961GHR VII nonessential pyruvate or indole-3-pyruvate decarboxylase pdc KEEP 951119..951182 951119 951182 I NA NA IG869_Rv0853c-Rv0854 KEEP 951183..951626 951183 951626 + 147 15607994 - Rv0854 COG0113H V nonessential hypothetical protein KEEP 951627..951631 951627 951631 I NA NA IG870_Rv0854-Rv0855 KEEP 951632..952711 951632 952711 + 359 15607995 far Rv0855 COG1804C I.A.3 nonessential fatty-acid-CoA racemase KEEP 952712..952824 952712 952824 I NA NA IG871_Rv0855-Rv0856 KEEP 952825..953229 952825 953229 + 134 15607996 - Rv0856 - V nonessential hypothetical protein KEEP 953230..953256 953230 953256 I NA NA IG872_Rv0856-Rv0857 KEEP 953257..953730 953257 953730 + 157 57116792 - Rv0857 - V nonessential hypothetical protein KEEP 953727..954920 953727 954920 - 397 15607998 - Rv0858c COG0436E IV.H nonessential aminotransferase KEEP 954921..955076 954921 955076 I NA NA IG874_Rv0858c-Rv0859 KEEP 955077..956288 955077 956288 + 403 15607999 fadA Rv0859 COG0183I I.A.3 nonessential acetyl-CoA acetyltransferase KEEP 956289..956292 956289 956292 I NA NA IG875_Rv0859-Rv0860 KEEP 956293..958455 956293 958453 + 720 15608000 fadB Rv0860 COG1024I,COG1250I I.A.3 nonessential fatty oxidation protein FadB KEEP 956293..958455 958454 958455 + 720 15608000 fadB Rv0860 COG1024I,COG1250I I.A.3 nonessential fatty oxidation protein FadB Only Marin et al 2022 KEEP 958456..958522 958456 958522 I NA NA IG876_Rv0860-Rv0861c Only Marin et al 2022 KEEP 958523..960151 958523 960151 - 542 15608001 ercc3 Rv0861c COG1061KL II.A.5 nonessential DNA helicase ErcC3 KEEP 960152..960341 960152 960160 I NA NA IG877_Rv0861c-Rv0862c KEEP 960152..960341 960161 960332 I NA NA IG877_Rv0861c-Rv0862c Only Marin et al 2022 KEEP 960152..960341 960333 960341 I NA NA IG877_Rv0861c-Rv0862c KEEP 960342..962612 960342 962612 - 756 15608002 - Rv0862c - V nonessential hypothetical protein KEEP 962599..962880 962599 962880 + 93 15608003 - Rv0863 - V nonessential hypothetical protein KEEP 962881..962889 962881 962889 I NA NA IG879_Rv0863-Rv0864 KEEP 962890..963393 962890 963393 + 167 15608004 moaC Rv0864 COG0315H I.G.4 nonessential molybdenum cofactor biosynthesis protein C KEEP 963390..963872 963390 963872 + 160 15608005 mog Rv0865 COG0521H I.G.4 nonessential molybdopterin biosynthesis Mog protein KEEP 963869..964294 963869 964294 + 141 15608006 moaE2 Rv0866 COG0314H I.G.4 nonessential molybdenum cofactor biosynthesis protein E2 KEEP 964295..964311 964295 964311 I NA NA IG882_Rv0866-Rv0867c KEEP 964312..965535 964312 964576 - 407 15608007 rpfA Rv0867c - VI nonessential resuscitation-promoting factor RpfA KEEP 964312..965535 964577 965082 - 407 15608007 rpfA Rv0867c - VI nonessential resuscitation-promoting factor RpfA Only Marin et al 2022 KEEP 964312..965535 965083 965535 - 407 15608007 rpfA Rv0867c - VI nonessential resuscitation-promoting factor RpfA KEEP 965536..965982 965536 965982 I NA NA IG883_Rv0867c-Rv0868c KEEP 965983..966261 965983 966261 - 92 15608008 moaD2 Rv0868c COG1977H I.G.4 nonessential molybdenum cofactor biosynthesis protein D KEEP 966262..966264 966262 966264 I NA NA IG884_Rv0868c-Rv0869c KEEP 966265..967347 966265 967347 - 360 15608009 moaA Rv0869c COG2896H I.G.4 nonessential molybdenum cofactor biosynthesis protein A KEEP 967344..967733 967344 967733 - 129 15608010 - Rv0870c COG3304S II.C.5 nonessential hypothetical protein KEEP 967734..967897 967734 967897 I NA NA IG886_Rv0870c-Rv0871 KEEP 967898..968305 967898 968305 + 135 15608011 cspB Rv0871 COG1278K III.E nonessential cold shock-like protein B CspB KEEP 968306..968423 968306 968423 I NA NA IG887_Rv0871-Rv0872c KEEP 968424..970244 968424 968778 - 606 57116793 PE_PGRS15 Rv0872c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 968424..970244 968779 968829 - 606 57116793 PE_PGRS15 Rv0872c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 968424..970244 968830 969614 - 606 57116793 PE_PGRS15 Rv0872c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 968424..970244 969615 969752 - 606 57116793 PE_PGRS15 Rv0872c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 968424..970244 969753 969873 - 606 57116793 PE_PGRS15 Rv0872c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 968424..970244 969874 969934 - 606 57116793 PE_PGRS15 Rv0872c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 968424..970244 969935 970244 - 606 57116793 PE_PGRS15 Rv0872c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 970245..970504 970245 970504 I NA NA IG888_Rv0872c-Rv0873 KEEP 970505..972457 970505 972457 + 650 15608013 fadE10 Rv0873 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE10 KEEP 972458..972545 972458 972545 I NA NA IG889_Rv0873-Rv0874c KEEP 972546..973706 972546 972604 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein KEEP 972546..973706 972605 972720 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein Only Marin et al 2022 KEEP 972546..973706 972721 972921 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein KEEP 972546..973706 972922 972994 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein Only Marin et al 2022 KEEP 972546..973706 972995 973176 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein KEEP 972546..973706 973177 973340 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein Only Marin et al 2022 KEEP 972546..973706 973341 973430 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein KEEP 972546..973706 973431 973482 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein Only Marin et al 2022 KEEP 972546..973706 973483 973706 - 386 15608014 - Rv0874c COG4398S V nonessential hypothetical protein KEEP 973707..973805 973707 973761 I NA NA IG890_Rv0874c-Rv0875c KEEP 973707..973805 973762 973786 I NA NA IG890_Rv0874c-Rv0875c Only Marin et al 2022 KEEP 973707..973805 973787 973805 I NA NA IG890_Rv0874c-Rv0875c KEEP 973806..974294 973806 974294 - 162 15608015 - Rv0875c - VI essential hypothetical protein KEEP 974291..975937 974291 975937 - 548 15608016 - Rv0876c COG0477GEPR II.C.5 nonessential transmembrane protein KEEP 975938..976074 975938 976074 I NA NA IG892_Rv0876c-Rv0877 KEEP 976075..976863 976075 976863 + 262 15608017 - Rv0877 - V nonessential hypothetical protein KEEP 976864..976871 976864 976871 I NA NA IG893_Rv0877-Rv0878c KEEP 976872..978203 976872 976896 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + homoplasy analysis DISCARD 976872..978203 976897 976913 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 976872..978203 976914 977516 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 976872..978203 977517 977570 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 976872..978203 977571 977978 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 976872..978203 977979 978031 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 976872..978203 978032 978086 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 976872..978203 978087 978143 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 976872..978203 978144 978203 - 443 57116794 PPE13 Rv0878c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 978204..978480 978204 978480 I NA NA IG894_Rv0878c-Rv0879c KEEP 978481..978756 978481 978756 - 91 15608019 - Rv0879c - II.C.5 nonessential transmembrane protein KEEP 978757..978933 978757 978933 I NA NA IG895_Rv0879c-Rv0880 KEEP 978934..979365 978934 979365 + 143 15608020 - Rv0880 COG1846K I.J.1 nonessential MarR family transcriptional regulator KEEP 979362..980228 979362 980228 + 288 15608021 - Rv0881 COG0566J IV.H nonessential rRNA methyltransferase KEEP 980225..980509 980225 980509 + 94 15608022 - Rv0882 - II.C.5 nonessential hypothetical protein KEEP 980506..981267 980506 981267 - 253 15608023 - Rv0883c - V essential hypothetical protein KEEP 981268..981423 981268 981423 I NA NA IG899_Rv0883c-Rv0884c KEEP 981424..982554 981424 982554 - 376 15608024 serC Rv0884c COG1932HE I.D.3 essential phosphoserine aminotransferase KEEP 982555..982761 982555 982761 I NA NA IG900_Rv0884c-Rv0885 KEEP 982762..983784 982762 983784 + 340 15608025 - Rv0885 - V nonessential hypothetical protein KEEP 983785..983802 983785 983802 I NA NA IG901_Rv0885-Rv0886 KEEP 983803..985530 983803 985530 + 575 15608026 fprB Rv0886 COG0493ER,COG1146C I.B.6c nonessential NADPH:adrenodoxin oxidoreductase FprB KEEP 985513..985971 985513 985971 - 152 15608027 - Rv0887c COG2764S V nonessential hypothetical protein KEEP 985972..987232 985972 987232 I NA NA IG903_Rv0887c-Rv0888 KEEP 987233..988705 987233 988705 + 490 15608028 - Rv0888 - VI nonessential hypothetical protein KEEP 988706..988739 988706 988739 I NA NA IG904_Rv0888-Rv0889c KEEP 988740..989861 988740 989861 - 373 15608029 citA Rv0889c COG0372C I.B.3 nonessential citrate synthase 2 KEEP 989862..989947 989862 989947 I NA NA IG905_Rv0889c-Rv0890c KEEP 989948..992596 989948 992596 - 882 15608030 - Rv0890c COG2771K,COG3903R I.J.1 nonessential LuxR family transcriptional regulator KEEP 992598..993455 992598 993455 - 285 15608031 - Rv0891c COG2114T I.J.1 nonessential transcriptional regulatory protein KEEP 993456..993852 993456 993852 I NA NA IG907_Rv0891c-Rv0892 KEEP 993853..995340 993853 995340 + 495 15608032 - Rv0892 COG2072P VI nonessential monooxygenase KEEP 995318..996295 995318 996026 - 325 15608033 - Rv0893c COG3315Q V nonessential hypothetical protein KEEP 995318..996295 996027 996089 - 325 15608033 - Rv0893c COG3315Q V nonessential hypothetical protein Only Marin et al 2022 KEEP 995318..996295 996090 996295 - 325 15608033 - Rv0893c COG3315Q V nonessential hypothetical protein KEEP 996296..996523 996296 996523 I NA NA IG909_Rv0893c-Rv0894 KEEP 996524..997705 996524 997705 + 393 15608034 - Rv0894 COG3903R I.J.1 essential LuxR family transcriptional regulator KEEP 997706..997781 997706 997781 I NA NA IG910_Rv0894-Rv0895 KEEP 997782..999299 997782 999299 + 505 15608035 - Rv0895 COG1020Q V nonessential hypothetical protein KEEP 999300..999471 999300 999471 I NA NA IG911_Rv0895-Rv0896 KEEP 999472..1000767 999472 1000740 + 431 15608036 gltA Rv0896 COG0372C I.B.3 nonessential type II citrate synthase KEEP 999472..1000767 1000741 1000767 + 431 15608036 gltA Rv0896 COG0372C I.B.3 nonessential type II citrate synthase Only Marin et al 2022 KEEP 1000768..1000807 1000768 1000799 I NA NA IG912_Rv0896-Rv0897c Only Marin et al 2022 KEEP 1000768..1000807 1000800 1000807 I NA NA IG912_Rv0896-Rv0897c KEEP 1000808..1002415 1000808 1002415 - 535 15608037 - Rv0897c COG1233Q I.B.7 nonessential oxidoreductase KEEP 1002416..1002440 1002416 1002440 I NA NA IG913_Rv0897c-Rv0898c KEEP 1002441..1002704 1002441 1002704 - 87 15608038 - Rv0898c - V nonessential hypothetical protein KEEP 1002705..1002811 1002705 1002811 I NA NA IG914_Rv0898c-Rv0899 KEEP 1002812..1003792 1002812 1003792 + 326 15608039 ompA Rv0899 COG2885M II.C.2 nonessential outer membrane protein A OMPA KEEP 1003793..1003804 1003793 1003804 I NA NA IG915_Rv0899-Rv0900 KEEP 1003805..1003957 1003805 1003957 + 50 15608040 - Rv0900 - II.C.5 essential hypothetical protein KEEP 1003957..1004484 1003957 1004484 + 175 15608041 - Rv0901 - II.C.5 nonessential hypothetical protein KEEP 1004485..1004500 1004485 1004500 I NA NA IG917_Rv0901-Rv0902c KEEP 1004501..1005841 1004501 1005841 - 446 15608042 prrB Rv0902c COG0642T I.J.2 nonessential two component sensor histidine kinase PRRB KEEP 1005842..1005851 1005842 1005851 I NA NA IG918_Rv0902c-Rv0903c KEEP 1005852..1006562 1005852 1006562 - 236 15608043 prrA Rv0903c COG0745TK I.J.2 nonessential two component response transcriptional regulatory protein PRRA KEEP 1006563..1006692 1006563 1006692 I NA NA IG919_Rv0903c-Rv0904c KEEP 1006693..1008180 1006693 1008180 - 495 15608044 accD3 Rv0904c COG0777I,COG0825I I.H.1 nonessential putative acetyl-coenzyme A carboxylase carboxyl transferase (subunit BETA) ACCD3 (ACCASE BETA chain) KEEP 1008181..1008206 1008181 1008206 I NA NA IG920_Rv0904c-Rv0905 KEEP 1008207..1008938 1008207 1008938 + 243 15608045 echA6 Rv0905 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 1008939..1008943 1008939 1008943 I NA NA IG921_Rv0905-Rv0906 KEEP 1008944..1010062 1008944 1010062 + 372 15608046 - Rv0906 COG2220R V nonessential hypothetical protein KEEP 1010063..1010135 1010063 1010135 I NA NA IG922_Rv0906-Rv0907 KEEP 1010136..1011734 1010136 1011734 + 532 15608047 - Rv0907 COG1680V II.C.3 nonessential hypothetical protein KEEP 1011731..1014124 1011731 1014124 + 797 15608048 ctpE Rv0908 COG0474P III.A.2 nonessential metal cation transporter ATPase P-type CtpE KEEP 1014125..1014680 1014125 1014680 I NA NA IG924_Rv0908-Rv0909 KEEP 1014681..1014860 1014681 1014860 + 59 15608049 - Rv0909 - V nonessential hypothetical protein KEEP 1014861..1014865 1014861 1014865 I NA NA IG925_Rv0909-Rv0910 KEEP 1014866..1015300 1014866 1015300 + 144 15608050 - Rv0910 - V nonessential hypothetical protein KEEP 1015301..1015397 1015301 1015397 I NA NA IG926_Rv0910-Rv0911 KEEP 1015398..1016171 1015398 1016171 + 257 15608051 - Rv0911 COG3324R V nonessential hypothetical protein KEEP 1016172..1016235 1016172 1016235 I NA NA IG927_Rv0911-Rv0912 KEEP 1016236..1016685 1016236 1016685 + 149 15608052 - Rv0912 - II.C.5 nonessential transmembrane protein KEEP 1016686..1017216 1016686 1017216 I NA NA IG928_Rv0912-Rv0913c KEEP 1017217..1018725 1017217 1018725 - 502 15608053 - Rv0913c COG3670Q VI nonessential dioxygenase KEEP 1018727..1019965 1018727 1019965 - 412 15608054 - Rv0914c COG0183I I.H.3 nonessential acetyl-CoA acetyltransferase KEEP 1019966..1020057 1019966 1020057 I NA NA IG930_Rv0914c-Rv0915c KEEP 1020058..1021329 1020058 1021329 - 423 57116795 PPE14 Rv0915c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1021330..1021343 1021330 1021343 I NA NA IG931_Rv0915c-Rv0916c repeat KEEP 1021344..1021643 1021344 1021643 - 99 57116796 PE7 Rv0916c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1021644..1022086 1021644 1022086 I NA NA IG932_Rv0916c-Rv0917 KEEP 1022087..1023868 1022087 1023868 + 593 15608057 betP Rv0917 COG1292M III.A.1 nonessential glycine betaine transport integral membrane protein BetP KEEP 1023869..1024210 1023869 1024210 I NA NA IG933_Rv0917-Rv0918 KEEP 1024211..1024687 1024211 1024687 + 158 15608058 - Rv0918 COG4453S V nonessential hypothetical protein KEEP 1024684..1025184 1024684 1025184 + 166 15608059 - Rv0919 COG0454KR V nonessential hypothetical protein KEEP 1025185..1025496 1025185 1025496 I NA NA IG935_Rv0919-Rv0920c KEEP 1025497..1026816 1025497 1025866 - 439 15608060 - Rv0920c COG3328L IV.B.1 phage nonessential transposase KEEP 1025497..1026816 1025867 1025899 - 439 15608060 - Rv0920c COG3328L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1025497..1026816 1025900 1025900 - 439 15608060 - Rv0920c COG3328L IV.B.1 phage nonessential transposase KEEP 1025497..1026816 1025901 1025904 - 439 15608060 - Rv0920c COG3328L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1025497..1026816 1025905 1026816 - 439 15608060 - Rv0920c COG3328L IV.B.1 phage nonessential transposase KEEP 1026817..1027103 1026817 1027103 I NA NA IG936_Rv0920c-Rv0921 repeat KEEP 1027104..1027685 1027104 1027685 + 193 15608061 - Rv0921 COG2452L IV.B.1 phage nonessential resolvase KEEP 1027685..1029337 1027685 1029337 + 550 15608062 - Rv0922 COG0675L IV.B.1 phage nonessential transposase KEEP 1029338..1029512 1029338 1029512 I NA NA IG938_Rv0922-Rv0923c KEEP 1029513..1030577 1029513 1030577 - 354 15608063 - Rv0923c COG2105S,COG4195R V nonessential hypothetical protein KEEP 1030578..1031864 1030578 1031864 - 428 57116797 mntH Rv0924c COG1914P III.A.2 nonessential manganese transport protein MntH KEEP 1031865..1031895 1031865 1031895 I NA NA IG940_Rv0924c-Rv0925c KEEP 1031896..1032633 1031896 1032633 - 245 15608065 - Rv0925c COG0655R V nonessential hypothetical protein KEEP 1032634..1032709 1032634 1032709 I NA NA IG941_Rv0925c-Rv0926c KEEP 1032710..1033786 1032710 1033786 - 358 15608066 - Rv0926c COG3804S V nonessential hypothetical protein KEEP 1033787..1033839 1033787 1033839 I NA NA IG942_Rv0926c-Rv0927c KEEP 1033840..1034631 1033840 1034631 - 263 15608067 - Rv0927c COG1028IQR VI nonessential short chain dehydrogenase KEEP 1034632..1034902 1034632 1034902 I NA NA IG943_Rv0927c-Rv0928 KEEP 1034903..1036015 1034903 1036015 + 370 57116798 pstS3 Rv0928 COG0226P III.A.4 nonessential periplasmic phosphate-binding lipoprotein PSTS3 (PBP-3) (PSTS3) (PHOS1) KEEP 1036016..1036027 1036016 1036027 I NA NA IG944_Rv0928-Rv0929 KEEP 1036028..1037002 1036028 1037002 + 324 15608069 pstC2 Rv0929 COG0573P III.A.4 nonessential phosphate ABC transporter transmembrane protein KEEP 1036999..1037925 1036999 1037925 + 308 57116799 pstA1 Rv0930 COG0581P III.A.4 nonessential phosphate ABC transporter transmembrane protein KEEP 1037920..1039914 1037920 1039914 - 664 15608071 pknD Rv0931c COG0515RTKL,COG3391S I.J.3 nonessential transmembrane serine/threonine-protein kinase D PKND (protein kinase D) (STPK D) KEEP 1039915..1039935 1039915 1039935 I NA NA IG947_Rv0931c-Rv0932c KEEP 1039936..1041048 1039936 1041048 - 370 57116800 pstS2 Rv0932c COG0226P III.A.4 nonessential periplasmic phosphate-binding lipoprotein PSTS2 (PBP-2) (PSTS2) KEEP 1041049..1041263 1041049 1041263 I NA NA IG948_Rv0932c-Rv0933 KEEP 1041264..1042094 1041264 1042094 + 276 15608073 pstB Rv0933 COG1117P III.A.4 nonessential phosphate ABC transporter ATP-binding protein KEEP 1042095..1042114 1042095 1042114 I NA NA IG949_Rv0933-Rv0934 KEEP 1042115..1043239 1042115 1043239 + 374 57116801 pstS1 Rv0934 COG0226P III.A.4 nonessential periplasmic phosphate-binding lipoprotein PSTS1 (PBP-1) (PSTS1) KEEP 1043240..1043298 1043240 1043298 I NA NA IG950_Rv0934-Rv0935 KEEP 1043299..1044315 1043299 1044315 + 338 57116802 pstC1 Rv0935 COG0573P III.A.4 nonessential phosphate ABC transporter transmembrane protein KEEP 1044317..1045222 1044317 1045222 + 301 15608076 pstA2 Rv0936 COG0581P III.A.4 nonessential phosphate ABC transporter transmembrane protein KEEP 1045199..1046020 1045199 1046020 - 273 15608077 - Rv0937c COG1273S V nonessential hypothetical protein KEEP 1046021..1046135 1046021 1046135 I NA NA IG953_Rv0937c-Rv0938 KEEP 1046136..1048415 1046136 1048415 + 759 15608078 - Rv0938 COG1793L,COG3285L VII nonessential ATP-dependent DNA ligase KEEP 1048412..1050346 1048412 1050346 + 644 15608079 - Rv0939 COG0179Q,COG0491R II.B.6 nonessential bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase/cyclase/dehydrase KEEP 1050347..1050592 1050347 1050592 I NA NA IG955_Rv0939-Rv0940c KEEP 1050593..1051459 1050593 1051459 - 288 15608080 - Rv0940c COG2141C I.B.7 nonessential oxidoreductase KEEP 1051460..1051543 1051460 1051543 I NA NA IG956_Rv0940c-Rv0941c KEEP 1051544..1052317 1051544 1052317 - 257 15608081 - Rv0941c - V nonessential hypothetical protein KEEP 1052318..1052359 1052318 1052359 I NA NA IG957_Rv0941c-Rv0942 KEEP 1052360..1052638 1052360 1052638 + 92 15608082 - Rv0942 - VI nonessential hypothetical protein KEEP 1052639..1052695 1052639 1052695 I NA NA IG958_Rv0942-Rv0943c KEEP 1052696..1053736 1052696 1053736 - 346 15608083 - Rv0943c COG2072P VI nonessential monooxygenase KEEP 1053737..1053764 1053737 1053764 I NA NA IG959_Rv0943c-Rv0944 KEEP 1053765..1054241 1053765 1054241 + 158 15608084 - Rv0944 COG0266L II.A.5 nonessential formamidopyrimidine-DNA glycosylase KEEP 1054242..1054246 1054242 1054246 I NA NA IG960_Rv0944-Rv0945 KEEP 1054247..1055008 1054247 1055008 + 253 15608085 - Rv0945 COG1028IQR VI nonessential short chain dehydrogenase KEEP 1055009..1055023 1055009 1055023 I NA NA IG961_Rv0945-Rv0946c KEEP 1055024..1056685 1055024 1056685 - 553 15608086 pgi Rv0946c COG0166G I.B.1 essential glucose-6-phosphate isomerase KEEP 1056686..1057645 1056686 1056822 I NA NA IG962_Rv0946c-Rv0948c KEEP 1056686..1057645 1056823 1056829 I NA NA IG962_Rv0946c-Rv0948c Only Marin et al 2022 KEEP 1056686..1057645 1056830 1057645 I NA NA IG962_Rv0946c-Rv0948c KEEP 1057646..1057963 1057646 1057963 - 105 15608088 - Rv0948c COG1605E V nonessential hypothetical protein KEEP 1057964..1058259 1057964 1058259 I NA NA IG963_Rv0948c-Rv0949 KEEP 1058260..1060575 1058260 1060575 + 771 57116803 uvrD1 Rv0949 COG0210L II.A.5 essential ATP-dependent DNA helicase II UVRD1 KEEP 1060576..1060655 1060576 1060655 I NA NA IG964_Rv0949-Rv0950c KEEP 1060656..1061654 1060656 1061654 - 332 15608090 - Rv0950c COG0739M V essential hypothetical protein KEEP 1061655..1061963 1061655 1061963 I NA NA IG965_Rv0950c-Rv0951 KEEP 1061964..1063127 1061964 1063127 + 387 15608091 sucC Rv0951 COG0045C I.B.3 essential succinyl-CoA synthetase subunit beta KEEP 1063128..1063139 1063128 1063139 I NA NA IG966_Rv0951-Rv0952 KEEP 1063140..1064051 1063140 1064046 + 303 15608092 sucD Rv0952 COG0074C I.B.3 essential succinyl-CoA synthetase subunit alpha KEEP 1063140..1064051 1064047 1064051 + 303 15608092 sucD Rv0952 COG0074C I.B.3 essential succinyl-CoA synthetase subunit alpha Only Marin et al 2022 KEEP 1064052..1064113 1064052 1064113 I NA NA IG967_Rv0952-Rv0953c Only Marin et al 2022 KEEP 1064114..1064962 1064114 1064118 - 282 15608093 - Rv0953c COG2141C I.B.7 nonessential oxidoreductase Only Marin et al 2022 KEEP 1064114..1064962 1064119 1064962 - 282 15608093 - Rv0953c COG2141C I.B.7 nonessential oxidoreductase KEEP 1064963..1065126 1064963 1065126 I NA NA IG968_Rv0953c-Rv0954 KEEP 1065127..1066038 1065127 1066038 + 303 15608094 - Rv0954 - II.C.2 nonessential transmembrane protein KEEP 1066039..1066077 1066039 1066077 I NA NA IG969_Rv0954-Rv0955 KEEP 1066078..1067445 1066078 1066997 + 455 15608095 - Rv0955 - II.C.5 essential integral membrane protein KEEP 1066078..1067445 1066998 1067002 + 455 15608095 - Rv0955 - II.C.5 essential integral membrane protein Only Marin et al 2022 KEEP 1066078..1067445 1067003 1067445 + 455 15608095 - Rv0955 - II.C.5 essential integral membrane protein KEEP 1067446..1067560 1067446 1067560 I NA NA IG970_Rv0955-Rv0956 KEEP 1067561..1068208 1067561 1068208 + 215 15608096 purN Rv0956 COG0299F I.F.1 nonessential phosphoribosylglycinamide formyltransferase KEEP 1068205..1069776 1068205 1069776 + 523 15608097 purH Rv0957 COG0138F I.F.1 essential bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase KEEP 1069777..1069882 1069777 1069882 I NA NA IG972_Rv0957-Rv0958 KEEP 1069883..1071262 1069883 1070324 + 459 15608098 - Rv0958 COG1239H VII nonessential magnesium chelatase KEEP 1069883..1071262 1070325 1070330 + 459 15608098 - Rv0958 COG1239H VII nonessential magnesium chelatase Only Marin et al 2022 KEEP 1069883..1071262 1070331 1071257 + 459 15608098 - Rv0958 COG1239H VII nonessential magnesium chelatase KEEP 1069883..1071262 1071258 1071262 + 459 15608098 - Rv0958 COG1239H VII nonessential magnesium chelatase Only Marin et al 2022 KEEP 1071255..1073273 1071255 1071257 + 672 15608099 - Rv0959 COG4867R V nonessential hypothetical protein KEEP 1071255..1073273 1071258 1071318 + 672 15608099 - Rv0959 COG4867R V nonessential hypothetical protein Only Marin et al 2022 KEEP 1071255..1073273 1071319 1073273 + 672 15608099 - Rv0959 COG4867R V nonessential hypothetical protein KEEP 1073274..1073544 1073274 1073544 I NA NA IG974_Rv0959-Rv0960 KEEP 1073545..1073928 1073545 1073928 + 127 15608100 - Rv0960 COG4113R V nonessential hypothetical protein KEEP 1073929..1074073 1073929 1074073 I NA NA IG975_Rv0960-Rv0961 KEEP 1074074..1074421 1074074 1074421 + 115 15608101 - Rv0961 - II.C.5 nonessential integral membrane protein KEEP 1074422..1074439 1074422 1074439 I NA NA IG976_Rv0961-Rv0962c KEEP 1074440..1075114 1074440 1075114 - 224 15608102 lprP Rv0962c COG1902C,COG4608E II.C.1 nonessential lipoprotein LprP KEEP 1075115..1075296 1075115 1075296 I NA NA IG977_Rv0962c-Rv0963c KEEP 1075297..1076097 1075297 1076097 - 266 15608103 - Rv0963c - V nonessential hypothetical protein KEEP 1076098..1076195 1076098 1076195 I NA NA IG978_Rv0963c-Rv0964c KEEP 1076196..1076678 1076196 1076678 - 160 15608104 - Rv0964c - VI nonessential hypothetical protein KEEP 1076679..1076777 1076679 1076777 I NA NA IG979_Rv0964c-Rv0965c KEEP 1076778..1077197 1076778 1077197 - 139 15608105 - Rv0965c - V nonessential hypothetical protein KEEP 1077198..1077232 1077198 1077232 I NA NA IG980_Rv0965c-Rv0966c KEEP 1077233..1077835 1077233 1077835 - 200 57116804 - Rv0966c - V nonessential hypothetical protein KEEP 1077836..1077974 1077836 1077974 I NA NA IG981_Rv0966c-Rv0967 KEEP 1077975..1078334 1077975 1078334 + 119 15608107 - Rv0967 COG1937S V nonessential hypothetical protein KEEP 1078335..1078390 1078335 1078390 I NA NA IG982_Rv0967-Rv0968 KEEP 1078391..1078687 1078391 1078687 + 98 15608108 - Rv0968 - V nonessential hypothetical protein KEEP 1078688..1078742 1078688 1078742 I NA NA IG983_Rv0968-Rv0969 KEEP 1078743..1081055 1078743 1081055 + 770 15608109 ctpV Rv0969 COG2217P III.A.2 nonessential metal cation transporter P-type ATPase CtpV KEEP 1081052..1081684 1081052 1081684 + 210 15608110 - Rv0970 - II.C.5 nonessential integral membrane protein KEEP 1081685..1081774 1081685 1081774 I NA NA IG985_Rv0970-Rv0971c KEEP 1081775..1082584 1081775 1082584 - 269 15608111 echA7 Rv0971c COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 1082584..1083750 1082584 1083750 - 388 15608112 fadE12 Rv0972c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE12 KEEP 1083747..1085750 1083747 1085750 - 667 15608113 accA2 Rv0973c COG0439I,COG0511I,COG4770I I.A.3 essential acetyl-/propionyl-coenzyme A carboxylase subunit alpha KEEP 1085751..1085755 1085751 1085755 I NA NA IG988_Rv0973c-Rv0974c KEEP 1085756..1087345 1085756 1087345 - 529 15608114 accD2 Rv0974c COG4799I I.A.3 nonessential acetyl-/propionyl-CoA carboxylase subunit beta KEEP 1087346..1087347 1087346 1087347 I NA NA IG989_Rv0974c-Rv0975c KEEP 1087348..1088496 1087348 1088496 - 382 15608115 fadE13 Rv0975c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE13 KEEP 1088493..1090175 1088493 1090175 - 560 15608116 - Rv0976c - V nonessential hypothetical protein KEEP 1090176..1090372 1090176 1090372 I NA NA IG991_Rv0976c-Rv0977 KEEP 1090373..1093144 1090373 1090781 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1090782 1090783 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1090784 1090787 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1090788 1090793 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1090794 1090802 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1090803 1090814 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1090815 1090937 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1090938 1090940 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1090941 1090956 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1090957 1091137 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1091138 1091146 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1091147 1091152 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1091153 1091361 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1091362 1091368 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1091369 1091372 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1091373 1091379 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1091380 1091387 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1091388 1091846 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1091847 1091887 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1091888 1092021 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1092022 1092055 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1092056 1092089 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1092090 1092101 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1092102 1092104 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1092105 1092245 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1090373..1093144 1092246 1092263 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1090373..1093144 1092264 1093144 + 923 57116805 PE_PGRS16 Rv0977 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1093145..1093360 1093145 1093231 I NA NA IG992_Rv0977-Rv0978c repeat KEEP 1093145..1093360 1093232 1093320 I NA NA IG992_Rv0977-Rv0978c repeat Annotation + Marin et al 2022 DISCARD 1093145..1093360 1093321 1093360 I NA NA IG992_Rv0977-Rv0978c repeat KEEP 1093361..1094356 1093361 1093449 - 331 57116806 PE_PGRS17 Rv0978c COG3391S IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1093361..1094356 1093450 1093647 - 331 57116806 PE_PGRS17 Rv0978c COG3391S IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1093361..1094356 1093648 1093649 - 331 57116806 PE_PGRS17 Rv0978c COG3391S IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1093361..1094356 1093650 1094356 - 331 57116806 PE_PGRS17 Rv0978c COG3391S IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1094357..1094669 1094357 1094593 I NA NA IG993_Rv0978c-Rv0979c Annotation + Marin et al 2022 DISCARD 1094357..1094669 1094594 1094669 I NA NA IG993_Rv0978c-Rv0979c KEEP 1094670..1094864 1094670 1094864 - 64 57116807 - Rv0979c - II.A.1 nonessential hypothetical protein KEEP 1094865..1094885 1094865 1094885 I NA NA IG994_Rv0979c-Rv0979A Only Marin et al 2022 KEEP 1094886..1095059 1094886 1094953 + 57 57116808 rpmF Rv0979A - VI nonessential 50S ribosomal protein L32 Only Marin et al 2022 KEEP 1094886..1095059 1094954 1095059 + 57 57116808 rpmF Rv0979A - VI nonessential 50S ribosomal protein L32 KEEP 1095060..1095077 1095060 1095077 I NA NA IG995_Rv0979A-Rv0980c KEEP 1095078..1096451 1095078 1095202 - 457 57116809 PE_PGRS18 Rv0980c COG3391S IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1095078..1096451 1095203 1095325 - 457 57116809 PE_PGRS18 Rv0980c COG3391S IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1095078..1096451 1095326 1095330 - 457 57116809 PE_PGRS18 Rv0980c COG3391S IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1095078..1096451 1095331 1096451 - 457 57116809 PE_PGRS18 Rv0980c COG3391S IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1096452..1096815 1096452 1096699 I NA NA IG996_Rv0980c-Rv0981 Annotation + Marin et al 2022 DISCARD 1096452..1096815 1096700 1096815 I NA NA IG996_Rv0980c-Rv0981 KEEP 1096816..1097508 1096816 1097508 + 230 15608121 mprA Rv0981 COG0745TK I.J.2 nonessential two component response transcriptional regulatory protein MprA KEEP 1097508..1099022 1097508 1099022 + 504 15608122 mprB Rv0982 COG0642T I.J.2 essential two component sensor kinase MprB KEEP 1099023..1099065 1099023 1099065 I NA NA IG998_Rv0982-Rv0983 KEEP 1099066..1100460 1099066 1100460 + 464 15608123 pepD Rv0983 COG0265O II.B.3 nonessential serine protease PepD KEEP 1100460..1101005 1100460 1101005 + 181 15608124 moaB2 Rv0984 COG0521H I.G.4 nonessential pterin-4-alpha-carbinolamine dehydratase MoaB2 KEEP 1101006..1101024 1101006 1101024 I NA NA IG1000_Rv0984-Rv0985c KEEP 1101025..1101480 1101025 1101480 - 151 15608125 mscL Rv0985c COG1970M VII nonessential large-conductance mechanosensitive channel KEEP 1101481..1101802 1101481 1101802 I NA NA IG1001_Rv0985c-Rv0986 KEEP 1101803..1102549 1101803 1102549 + 248 15608126 - Rv0986 COG1136V III.A nonessential adhesion component transport ATP-binding protein ABC transporter KEEP 1102542..1105109 1102542 1105109 + 855 15608127 - Rv0987 COG0577V II.C.5 nonessential adhesion component transport transmembrane protein ABC transporter KEEP 1105110..1105115 1105110 1105115 I NA NA IG1003_Rv0987-Rv0988 KEEP 1105116..1106276 1105116 1106276 + 386 15608128 - Rv0988 COG5621R VI nonessential hypothetical protein KEEP 1106277..1106404 1106277 1106404 I NA NA IG1004_Rv0988-Rv0989c KEEP 1106405..1107382 1106405 1107382 - 325 15608129 grcC2 Rv0989c COG0142H I.G.11 nonessential polyprenyl-diphosphate synthase KEEP 1107383..1107442 1107383 1107442 I NA NA IG1005_Rv0989c-Rv0990c KEEP 1107443..1108099 1107443 1108099 - 218 15608130 - Rv0990c - VI nonessential hypothetical protein KEEP 1108100..1108171 1108100 1108171 I NA NA IG1006_Rv0990c-Rv0991c KEEP 1108172..1108504 1108172 1108504 - 110 15608131 - Rv0991c COG2331S V nonessential putative serine rich protein KEEP 1108505..1108577 1108505 1108577 I NA NA IG1007_Rv0991c-Rv0992c KEEP 1108578..1109171 1108578 1109171 - 197 15608132 - Rv0992c COG0212H V nonessential hypothetical protein KEEP 1109172..1109271 1109172 1109271 I NA NA IG1008_Rv0992c-Rv0993 KEEP 1109272..1110192 1109272 1110192 + 306 15608133 galU Rv0993 COG1210M I.A.1 essential UTP--glucose-1-phosphate uridylyltransferase GalU KEEP 1110193..1110268 1110193 1110268 I NA NA IG1009_Rv0993-Rv0994 KEEP 1110269..1111549 1110269 1111549 + 426 57116810 moeA1 Rv0994 COG0303H I.G.4 nonessential molybdopterin biosynthesis protein MoeA1 KEEP 1111550..1111611 1111550 1111611 I NA NA IG1010_Rv0994-Rv0995 KEEP 1111612..1112223 1111612 1112223 + 203 15608135 rimJ Rv0995 COG1670J II.A.1 nonessential ribosomal-protein-alanine acetyltransferase KEEP 1112224..1112383 1112224 1112383 I NA NA IG1011_Rv0995-Rv0996 KEEP 1112384..1113460 1112384 1113460 + 358 15608136 - Rv0996 - II.C.5 nonessential transmembrane protein KEEP 1113461..1114292 1113461 1114292 I NA NA IG1012_Rv0996-Rv0997 KEEP 1114293..1114724 1114293 1114724 + 143 15608137 - Rv0997 - VI nonessential hypothetical protein KEEP 1114725..1114747 1114725 1114747 I NA NA IG1013_Rv0997-Rv0998 KEEP 1114748..1115749 1114748 1115749 + 333 15608138 - Rv0998 COG0454KR,COG0664T V nonessential hypothetical protein KEEP 1115750..1115766 1115750 1115766 I NA NA IG1014_Rv0998-Rv0999 KEEP 1115767..1116525 1115767 1116525 + 252 15608139 - Rv0999 - VI nonessential hypothetical protein KEEP 1116526..1116530 1116526 1116530 I NA NA IG1015_Rv0999-Rv1000c KEEP 1116531..1117148 1116531 1117148 - 205 57116811 - Rv1000c COG3145L V nonessential hypothetical protein KEEP 1117149..1117184 1117149 1117184 I NA NA IG1016_Rv1000c-Rv1001 KEEP 1117185..1118393 1117185 1118393 + 402 15608141 arcA Rv1001 COG2235E I.A.2 nonessential arginine deiminase KEEP 1118394..1118427 1118394 1118427 I NA NA IG1017_Rv1001-Rv1002c KEEP 1118428..1119939 1118428 1119939 - 503 15608142 - Rv1002c COG1928O II.C.5 essential hypothetical protein KEEP 1119940..1120021 1119940 1120021 I NA NA IG1018_Rv1002c-Rv1003 KEEP 1120022..1120879 1120022 1120879 + 285 15608143 - Rv1003 COG0313R V nonessential hypothetical protein KEEP 1120880..1120888 1120880 1120888 I NA NA IG1019_Rv1003-Rv1004c KEEP 1120889..1122148 1120889 1121039 - 419 15608144 - Rv1004c - II.C.5 nonessential hypothetical protein KEEP 1120889..1122148 1121040 1121090 - 419 15608144 - Rv1004c - II.C.5 nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 1120889..1122148 1121091 1121120 - 419 15608144 - Rv1004c - II.C.5 nonessential hypothetical protein KEEP 1120889..1122148 1121121 1121171 - 419 15608144 - Rv1004c - II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 1120889..1122148 1121172 1121656 - 419 15608144 - Rv1004c - II.C.5 nonessential hypothetical protein KEEP 1120889..1122148 1121657 1121731 - 419 15608144 - Rv1004c - II.C.5 nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 1120889..1122148 1121732 1122148 - 419 15608144 - Rv1004c - II.C.5 nonessential hypothetical protein KEEP 1122149..1122221 1122149 1122221 I NA NA IG1020_Rv1004c-Rv1005c KEEP 1122222..1123598 1122222 1123598 - 458 15608145 pabB Rv1005c COG0147EH I.G.2 essential para-aminobenzoate synthase component I KEEP 1123599..1123713 1123599 1123713 I NA NA IG1021_Rv1005c-Rv1006 KEEP 1123714..1125417 1123714 1125417 + 567 15608146 - Rv1006 - VI nonessential hypothetical protein KEEP 1125418..1125443 1125418 1125443 I NA NA IG1022_Rv1006-Rv1007c KEEP 1125444..1127003 1125444 1127003 - 519 15608147 metG Rv1007c COG0143J II.A.3 essential methionyl-tRNA synthetase KEEP 1127004..1127088 1127004 1127088 I NA NA IG1023_Rv1007c-Rv1008 KEEP 1127089..1127883 1127089 1127883 + 264 15608148 tatD Rv1008 COG0084L VII nonessential deoxyribonuclease TatD (YjjV protein) KEEP 1127884..1128090 1127884 1128090 I NA NA IG1024_Rv1008-Rv1009 KEEP 1128091..1129179 1128091 1129179 + 362 15608149 rpfB Rv1009 COG3583S VII nonessential resuscitation-promoting factor rpfB KEEP 1129152..1130105 1129152 1130105 + 317 15608150 ksgA Rv1010 COG0030J II.A.2 nonessential dimethyladenosine transferase KEEP 1130106..1130190 1130106 1130190 I NA NA IG1026_Rv1010-Rv1011 KEEP 1130191..1131111 1130191 1131111 + 306 15608151 ispE Rv1011 COG1947I VII essential 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase KEEP 1131112..1131127 1131112 1131127 I NA NA IG1027_Rv1011-Rv1012 KEEP 1131128..1131421 1131128 1131421 + 97 15608152 - Rv1012 - VI nonessential hypothetical protein KEEP 1131422..1131624 1131422 1131624 I NA NA IG1028_Rv1012-Rv1013 KEEP 1131625..1133259 1131625 1133259 + 544 15608153 pks16 Rv1013 COG0318IQ I.I essential acyl-CoA synthetase KEEP 1133260..1133332 1133260 1133279 I NA NA IG1029_Rv1013-Rv1014c KEEP 1133260..1133332 1133280 1133283 I NA NA IG1029_Rv1013-Rv1014c Only Marin et al 2022 KEEP 1133260..1133332 1133284 1133332 I NA NA IG1029_Rv1013-Rv1014c KEEP 1133333..1133908 1133333 1133908 - 191 15608154 pth Rv1014c COG0193J II.B.1 essential peptidyl-tRNA hydrolase KEEP 1133909..1133920 1133909 1133920 I NA NA IG1030_Rv1014c-Rv1015c KEEP 1133921..1134568 1133921 1134568 - 215 15608155 rplY Rv1015c COG1825J II.A.1 nonessential 50S ribosomal protein L25/general stress protein Ctc KEEP 1134569..1134784 1134569 1134784 I NA NA IG1031_Rv1015c-Rv1016c KEEP 1134785..1135465 1134785 1135465 - 226 15608156 lpqT Rv1016c - II.C.1 essential lipoprotein LpqT KEEP 1135466..1135500 1135466 1135500 I NA NA IG1032_Rv1016c-Rv1017c KEEP 1135501..1136481 1135501 1136481 - 326 15608157 prsA Rv1017c COG0462FE I.F.1 essential ribose-phosphate pyrophosphokinase KEEP 1136482..1136572 1136482 1136572 I NA NA IG1033_Rv1017c-Rv1018c KEEP 1136573..1138060 1136573 1138060 - 495 15608158 glmU Rv1018c COG1207M II.C.3 essential UDP-N-acetylglucosamine pyrophosphorylase glmU KEEP 1138061..1138314 1138061 1138314 I NA NA IG1034_Rv1018c-Rv1019 KEEP 1138315..1138908 1138315 1138908 + 197 15608159 - Rv1019 COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 1138909..1138966 1138909 1138966 I NA NA IG1035_Rv1019-Rv1020 KEEP 1138967..1142671 1138967 1142671 + 1234 15608160 mfd Rv1020 COG1197LK II.A.5 nonessential transcription-repair coupling factor Mfd (TRCF) KEEP 1142671..1143648 1142671 1143648 + 325 15608161 - Rv1021 COG1694R V essential nucleoside triphosphate pyrophosphohydrolase KEEP 1143649..1143735 1143649 1143735 I NA NA IG1037_Rv1021-Rv1022 KEEP 1143736..1144467 1143736 1144467 + 243 15608162 lpqU Rv1022 COG2951M II.C.1 nonessential lipoprotein LpqU KEEP 1144468..1144563 1144468 1144563 I NA NA IG1038_Rv1022-Rv1023 KEEP 1144564..1145853 1144564 1145286 + 429 15608163 eno Rv1023 COG0148G I.B.1 essential phosphopyruvate hydratase KEEP 1144564..1145853 1145287 1145317 + 429 15608163 eno Rv1023 COG0148G I.B.1 essential phosphopyruvate hydratase Only Marin et al 2022 KEEP 1144564..1145853 1145318 1145853 + 429 15608163 eno Rv1023 COG0148G I.B.1 essential phosphopyruvate hydratase KEEP 1145854..1145857 1145854 1145857 I NA NA IG1039_Rv1023-Rv1024 KEEP 1145858..1146544 1145858 1146544 + 228 15608164 - Rv1024 COG2919D II.C.5 essential hypothetical protein KEEP 1146545..1146560 1146545 1146560 I NA NA IG1040_Rv1024-Rv1025 KEEP 1146561..1147028 1146561 1147028 + 155 15608165 - Rv1025 COG1507S V essential hypothetical protein KEEP 1147019..1147978 1147019 1147978 + 319 15608166 - Rv1026 COG0248FP III.E essential hypothetical protein KEEP 1147979..1148426 1147979 1148426 I NA NA IG1042_Rv1026-Rv1027c KEEP 1148427..1149107 1148427 1149107 - 226 15608167 kdpE Rv1027c COG0745TK I.J.2 essential transcriptional regulatory protein KdpE KEEP 1149104..1151686 1149104 1151686 - 860 15608168 kdpD Rv1028c COG2205T II.C.5 essential sensor protein KDPD KEEP 1151687..1151919 1151687 1151919 I NA NA IG1044_Rv1028c-Rv1028A KEEP 1151920..1152012 1151920 1152012 + 30 57116812 kdpF Rv1028A - I.J.2 nonessential membrane protein kdpF KEEP 1152012..1153727 1152012 1153727 + 571 15608169 kdpA Rv1029 COG2060P III.A.2 nonessential potassium-transporting ATPase subunit A KEEP 1153724..1155853 1153724 1155853 + 709 15608170 kdpB Rv1030 COG2216P III.A.2 nonessential potassium-transporting ATPase subunit B KEEP 1155853..1156422 1155853 1156422 + 189 15608171 kdpC Rv1031 COG2156P III.A.2 nonessential potassium-transporting ATPase C chain KDPC (potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (potassium binding and translocating subunit C) KEEP 1156423..1156425 1156423 1156425 I NA NA IG1048_Rv1031-Rv1032c KEEP 1156426..1157955 1156426 1157955 - 509 15608172 trcS Rv1032c COG0642T I.J.2 nonessential two component sensor histidine kinase TRCS KEEP 1157956..1157962 1157956 1157962 I NA NA IG1049_Rv1032c-Rv1033c KEEP 1157963..1158736 1157963 1158736 - 257 15608173 trcR Rv1033c COG0745TK I.J.2 nonessential two component transcriptional regulator TRCR KEEP 1158737..1158917 1158737 1158917 I NA NA IG1050_Rv1033c-Rv1034c KEEP 1158918..1159307 1158918 1159194 - 129 15608174 - Rv1034c COG3039L IV.B.1 phage nonessential transposase KEEP 1158918..1159307 1159195 1159245 - 129 15608174 - Rv1034c COG3039L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1158918..1159307 1159246 1159307 - 129 15608174 - Rv1034c COG3039L IV.B.1 phage nonessential transposase KEEP 1159308..1159374 1159308 1159374 I NA NA IG1051_Rv1034c-Rv1035c repeat KEEP 1159375..1160061 1159375 1160061 - 228 15608175 - Rv1035c - IV.B.1 phage nonessential transposase KEEP 1160062..1160094 1160062 1160094 I NA NA IG1052_Rv1035c-Rv1036c KEEP 1160095..1160433 1160095 1160330 - 112 15608176 - Rv1036c - IV.B.1 nonessential truncated IS1560 transposase KEEP 1160095..1160433 1160331 1160421 - 112 15608176 - Rv1036c - IV.B.1 nonessential truncated IS1560 transposase Only Marin et al 2022 KEEP 1160095..1160433 1160422 1160433 - 112 15608176 - Rv1036c - IV.B.1 nonessential truncated IS1560 transposase KEEP 1160434..1160543 1160434 1160536 I NA NA IG1053_Rv1036c-Rv1037c KEEP 1160434..1160543 1160537 1160543 I NA NA IG1053_Rv1036c-Rv1037c Only Marin et al 2022 KEEP 1160544..1160828 1160544 1160828 - 94 15608177 esxI Rv1037c - VI nonessential putative ESAT-6 like protein ESXI (ESAT-6 like protein 1) Marin et al 2022 + homoplasy analysis DISCARD 1160829..1160854 1160829 1160854 I NA NA IG1054_Rv1037c-Rv1038c Only Marin et al 2022 KEEP 1160855..1161151 1160855 1161151 - 98 15608178 esxJ Rv1038c - VI nonessential Esat-6 like protein esxJ (Esat-6 like protein 2) Only Marin et al 2022 KEEP 1161152..1161296 1161152 1161159 I NA NA IG1055_Rv1038c-Rv1039c Annotation + Marin et al 2022 DISCARD 1161152..1161296 1161160 1161296 I NA NA IG1055_Rv1038c-Rv1039c KEEP 1161297..1162472 1161297 1161300 - 391 57116813 PPE15 Rv1039c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1161297..1162472 1161301 1161365 - 391 57116813 PPE15 Rv1039c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1161297..1162472 1161366 1162472 - 391 57116813 PPE15 Rv1039c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1162473..1162548 1162473 1162548 I NA NA IG1056_Rv1039c-Rv1040c repeat KEEP 1162549..1163376 1162549 1162561 - 275 57116814 PE8 Rv1040c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1162549..1163376 1162562 1162612 - 275 57116814 PE8 Rv1040c - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 1162549..1163376 1162613 1163376 - 275 57116814 PE8 Rv1040c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1163377..1164571 1163377 1164563 I NA NA IG1057_Rv1040c-Rv1041c KEEP 1163377..1164571 1164564 1164571 I NA NA IG1057_Rv1040c-Rv1041c Annotation + Marin et al 2022 DISCARD 1164572..1165435 1164572 1165435 - 287 15608181 - Rv1041c COG3293L IV.B.1 phage nonessential IS like-2 transposase Annotation + Marin et al 2022 DISCARD 1165092..1165499 1165092 1165499 - 135 15608182 - Rv1042c COG3293L IV.B.1 phage nonessential IS like-2 transposase Annotation + Marin et al 2022 DISCARD 1165500..1165780 1165500 1165555 I NA NA IG1059_Rv1042c-Rv1043c Annotation + Marin et al 2022 DISCARD 1165500..1165780 1165556 1165780 I NA NA IG1059_Rv1042c-Rv1043c KEEP 1165781..1166806 1165781 1166806 - 341 15608183 - Rv1043c COG0265O V nonessential hypothetical protein KEEP 1166807..1167052 1166807 1167052 I NA NA IG1060_Rv1043c-Rv1044 KEEP 1167053..1167676 1167053 1167676 + 207 15608184 - Rv1044 - V nonessential hypothetical protein KEEP 1167673..1168554 1167673 1168554 + 293 15608185 - Rv1045 - VI nonessential hypothetical protein KEEP 1168555..1168703 1168555 1168703 I NA NA IG1062_Rv1045-Rv1046c KEEP 1168704..1169228 1168704 1169228 - 174 57116815 - Rv1046c - VI nonessential hypothetical protein KEEP 1169229..1169422 1169229 1169291 I NA NA IG1063_Rv1046c-Rv1047 KEEP 1169229..1169422 1169292 1169422 I NA NA IG1063_Rv1046c-Rv1047 Annotation + Marin et al 2022 DISCARD 1169423..1170670 1169423 1170670 + 415 15608187 - Rv1047 COG3328L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1170671..1171037 1170671 1170739 I NA NA IG1064_Rv1047-Rv1048c Annotation + Marin et al 2022 DISCARD 1170671..1171037 1170740 1171037 I NA NA IG1064_Rv1047-Rv1048c KEEP 1171038..1172153 1171038 1172153 - 371 15608188 - Rv1048c - VI nonessential hypothetical protein KEEP 1172154..1172385 1172154 1172385 I NA NA IG1065_Rv1048c-Rv1049 KEEP 1172386..1172832 1172386 1172832 + 148 15608189 - Rv1049 COG1846K I.J.1 nonessential transcriptional repressor protein KEEP 1172833..1172880 1172833 1172880 I NA NA IG1066_Rv1049-Rv1050 KEEP 1172881..1173786 1172881 1173786 + 301 15608190 - Rv1050 COG1028IQR I.B.7 nonessential oxidoreductase KEEP 1173787..1173944 1173787 1173944 I NA NA IG1067_Rv1050-Rv1051c KEEP 1173945..1174700 1173945 1174700 - 251 15608191 - Rv1051c - V nonessential hypothetical protein KEEP 1174701..1175722 1174701 1175722 I NA NA IG1068_Rv1051c-Rv1052 KEEP 1175723..1176112 1175723 1176112 + 129 15608192 - Rv1052 - VI nonessential hypothetical protein KEEP 1176011..1176286 1176011 1176286 - 91 15608193 - Rv1053c - VI nonessential hypothetical protein KEEP 1176287..1176927 1176287 1176927 I NA NA IG1070_Rv1053c-Rv1054 KEEP 1176928..1177242 1176928 1177242 + 104 57116816 - Rv1054 - IV.B.3 phage nonessential integrase KEEP 1177239..1177373 1177239 1177373 + 44 57116817 - Rv1055 - IV.B.3 nonessential hypothetical protein KEEP 1177374..1177627 1177374 1177627 I NA NA IG1072_Rv1055-Rv1056 KEEP 1177628..1178392 1177628 1178392 + 254 15608196 - Rv1056 COG2343S V nonessential hypothetical protein KEEP 1178393..1179395 1178393 1179345 I NA NA IG1073_Rv1056-Rv1057 KEEP 1178393..1179395 1179346 1179395 I NA NA IG1073_Rv1056-Rv1057 Only Marin et al 2022 KEEP 1179396..1180577 1179396 1179397 + 393 15608197 - Rv1057 COG3391S V nonessential hypothetical protein Only Marin et al 2022 KEEP 1179396..1180577 1179398 1180577 + 393 15608197 - Rv1057 COG3391S V nonessential hypothetical protein KEEP 1180578..1180683 1180578 1180683 I NA NA IG1074_Rv1057-Rv1058 KEEP 1180684..1182315 1180684 1182315 + 543 15608198 fadD14 Rv1058 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1182316..1182390 1182316 1182320 I NA NA IG1075_Rv1058-Rv1059 KEEP 1182316..1182390 1182321 1182382 I NA NA IG1075_Rv1058-Rv1059 Only Marin et al 2022 KEEP 1182316..1182390 1182383 1182390 I NA NA IG1075_Rv1058-Rv1059 KEEP 1182391..1183455 1182391 1183455 + 354 15608199 - Rv1059 COG0289E,COG3804S V nonessential hypothetical protein KEEP 1183456..1183507 1183456 1183507 I NA NA IG1076_Rv1059-Rv1060 KEEP 1183508..1183981 1183508 1183981 + 157 15608200 - Rv1060 - VI nonessential hypothetical protein KEEP 1183982..1184014 1183982 1184014 I NA NA IG1077_Rv1060-Rv1061 KEEP 1184015..1184878 1184015 1184878 + 287 15608201 - Rv1061 COG0121R V nonessential hypothetical protein KEEP 1184879..1184882 1184879 1184882 I NA NA IG1078_Rv1061-Rv1062 KEEP 1184883..1185740 1184883 1185740 + 285 15608202 - Rv1062 COG1752R V nonessential hypothetical protein KEEP 1185741..1186823 1185741 1186823 - 360 15608203 - Rv1063c COG1752R V nonessential hypothetical protein KEEP 1186824..1186903 1186824 1186903 I NA NA IG1080_Rv1063c-Rv1064c KEEP 1186904..1187323 1186904 1187323 - 139 15608204 lpqV Rv1064c - II.C.1 nonessential lipoprotein LpqV KEEP 1187324..1187434 1187324 1187434 I NA NA IG1081_Rv1064c-Rv1065 KEEP 1187435..1188001 1187435 1188001 + 188 15608205 - Rv1065 - V nonessential hypothetical protein KEEP 1187998..1188393 1187998 1188393 + 131 15608206 - Rv1066 COG0607P V nonessential hypothetical protein KEEP 1188394..1188420 1188394 1188420 I NA NA IG1083_Rv1066-Rv1067c KEEP 1188421..1190424 1188421 1188517 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1188421..1190424 1188518 1188908 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1188421..1190424 1188909 1188948 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1188421..1190424 1188949 1188955 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1188421..1190424 1188956 1188971 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1188421..1190424 1188972 1189047 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1188421..1190424 1189048 1189072 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1188421..1190424 1189073 1189075 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1188421..1190424 1189076 1189080 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1188421..1190424 1189081 1190177 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1188421..1190424 1190178 1190248 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1188421..1190424 1190249 1190299 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1188421..1190424 1190300 1190424 - 667 57116818 PE_PGRS19 Rv1067c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1190425..1190756 1190425 1190756 I NA NA IG1084_Rv1067c-Rv1068c repeat KEEP 1190757..1192148 1190757 1190853 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1190757..1192148 1190854 1190944 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1190757..1192148 1190945 1190968 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1190757..1192148 1190969 1191112 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1190757..1192148 1191113 1191129 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1190757..1192148 1191130 1191221 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1190757..1192148 1191222 1191247 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1190757..1192148 1191248 1191901 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1190757..1192148 1191902 1192148 - 463 57116819 PE_PGRS20 Rv1068c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1192149..1192509 1192149 1192509 I NA NA IG1085_Rv1068c-Rv1069c KEEP 1192510..1194273 1192510 1194273 - 587 15608209 - Rv1069c COG4425S V nonessential hypothetical protein KEEP 1194270..1195043 1194270 1195043 - 257 15608210 echA8 Rv1070c COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 1195044..1195054 1195044 1195054 I NA NA IG1087_Rv1070c-Rv1071c KEEP 1195055..1196092 1195055 1196092 - 345 15608211 echA9 Rv1071c COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 1196093..1196278 1196093 1196278 I NA NA IG1088_Rv1071c-Rv1072 KEEP 1196279..1197115 1196279 1197115 + 278 15608212 - Rv1072 COG4760S II.C.5 nonessential transmembrane protein KEEP 1197116..1197230 1197116 1197230 I NA NA IG1089_Rv1072-Rv1073 KEEP 1197231..1198082 1197231 1198082 + 283 15608213 - Rv1073 - V nonessential hypothetical protein KEEP 1198083..1198155 1198083 1198155 I NA NA IG1090_Rv1073-Rv1074c KEEP 1198156..1199373 1198156 1199373 - 405 15608214 fadA3 Rv1074c COG0183I I.A.3 nonessential acetyl-CoA acetyltransferase KEEP 1199374..1199425 1199374 1199425 I NA NA IG1091_Rv1074c-Rv1075c KEEP 1199426..1200370 1199426 1200370 - 314 15608215 - Rv1075c COG2755E VI nonessential hypothetical protein KEEP 1200371..1200766 1200371 1200522 I NA NA IG1092_Rv1075c-Rv1076 KEEP 1200371..1200766 1200523 1200544 I NA NA IG1092_Rv1075c-Rv1076 Only Marin et al 2022 KEEP 1200371..1200766 1200545 1200766 I NA NA IG1092_Rv1075c-Rv1076 KEEP 1200767..1201660 1200767 1201660 + 297 15608216 lipU Rv1076 COG0657I II.B.5 nonessential lipase LipU KEEP 1201661..1201716 1201661 1201716 I NA NA IG1093_Rv1076-Rv1077 KEEP 1201717..1203111 1201717 1203111 + 464 57116820 cbs Rv1077 COG0031E,COG0517R I.D.3 nonessential cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (hemoprotein H-450) KEEP 1203112..1203312 1203112 1203312 I NA NA IG1094_Rv1077-Rv1078 KEEP 1203313..1204035 1203313 1203333 + 240 15608218 pra Rv1078 COG1714S VI nonessential proline-rich antigen KEEP 1203313..1204035 1203334 1203396 + 240 15608218 pra Rv1078 COG1714S VI nonessential proline-rich antigen Only Marin et al 2022 KEEP 1203313..1204035 1203397 1204035 + 240 15608218 pra Rv1078 COG1714S VI nonessential proline-rich antigen KEEP 1204036..1204066 1204036 1204066 I NA NA IG1095_Rv1078-Rv1079 KEEP 1204067..1205233 1204067 1205233 + 388 15608219 metB Rv1079 COG0626E I.D.2 nonessential cystathionine gamma-synthase KEEP 1205234..1205303 1205234 1205303 I NA NA IG1096_Rv1079-Rv1080c KEEP 1205304..1205798 1205304 1205798 - 164 15608220 greA Rv1080c COG0782K II.A.6 nonessential transcription elongation factor GreA KEEP 1205799..1205983 1205799 1205983 I NA NA IG1097_Rv1080c-Rv1081c KEEP 1205984..1206418 1205984 1206418 - 144 15608221 - Rv1081c - II.C.4 nonessential hypothetical protein KEEP 1206419..1206519 1206419 1206519 I NA NA IG1098_Rv1081c-Rv1082 KEEP 1206520..1207386 1206520 1207386 + 288 15608222 mca Rv1082 COG2120S IV.D nonessential Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) KEEP 1207383..1207649 1207383 1207649 + 88 15608223 - Rv1083 - V nonessential hypothetical protein KEEP 1207636..1209657 1207636 1209657 + 673 15608224 - Rv1084 COG1331O V nonessential hypothetical protein KEEP 1209658..1209755 1209658 1209755 I NA NA IG1101_Rv1084-Rv1085c KEEP 1209756..1210484 1209756 1210484 - 242 15608225 - Rv1085c COG1272R IV.A nonessential hemolysin-like protein KEEP 1210485..1210594 1210485 1210594 I NA NA IG1102_Rv1085c-Rv1086 KEEP 1210595..1211383 1210595 1211383 + 262 15608226 - Rv1086 COG0020I IV.H nonessential short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase) KEEP 1211384..1211559 1211384 1211559 I NA NA IG1103_Rv1086-Rv1087 KEEP 1211560..1213863 1211560 1213863 + 767 57116821 PE_PGRS21 Rv1087 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1213864..1214039 1213864 1214039 I NA NA IG1104_Rv1087-Rv1087A KEEP 1214040..1214360 1214040 1214360 + 106 57116822 - Rv1087A COG0020I V nonessential hypothetical protein KEEP 1214361..1214512 1214361 1214512 I NA NA IG1105_Rv1087A-Rv1088 KEEP 1214513..1214947 1214513 1214947 + 144 57116823 PE9 Rv1088 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1214769..1215131 1214769 1215131 + 120 57116824 PE10 Rv1089 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1215132..1215516 1215132 1215516 I NA NA IG1107_Rv1089-Rv1089A KEEP 1215517..1215621 1215517 1215621 + 34 57116825 celA2a Rv1089A - IV.I nonessential endo-1,4-beta-glucanase KEEP 1215599..1216054 1215599 1216054 + 151 15608230 celA2b Rv1090 - II.B.4 nonessential endo-1,4-beta-glucanase KEEP 1216055..1216468 1216055 1216468 I NA NA IG1109_Rv1090-Rv1091 KEEP 1216469..1219030 1216469 1216547 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1216469..1219030 1216548 1216649 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1216469..1219030 1216650 1216716 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1216469..1219030 1216717 1216769 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1216469..1219030 1216770 1216816 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1216469..1219030 1216817 1217162 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1216469..1219030 1217163 1217166 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1216469..1219030 1217167 1217181 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1216469..1219030 1217182 1217415 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1216469..1219030 1217416 1218426 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1216469..1219030 1218427 1218435 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1216469..1219030 1218436 1218676 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1216469..1219030 1218677 1218701 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1216469..1219030 1218702 1218703 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1216469..1219030 1218704 1218967 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1216469..1219030 1218968 1218970 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1216469..1219030 1218971 1219030 + 853 57116826 PE_PGRS22 Rv1091 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + homoplasy analysis DISCARD 1219031..1219247 1219031 1219247 I NA NA IG1110_Rv1091-Rv1092c KEEP 1219248..1220186 1219248 1220186 - 312 15608232 coaA Rv1092c COG1072H I.G.5 essential pantothenate kinase KEEP 1220187..1220573 1220187 1220573 I NA NA IG1111_Rv1092c-Rv1093 KEEP 1220574..1221854 1220574 1221854 + 426 57116827 glyA Rv1093 COG0112E I.D.3 nonessential serine hydroxymethyltransferase KEEP 1221855..1221958 1221855 1221958 I NA NA IG1112_Rv1093-Rv1094 KEEP 1221959..1222786 1221959 1222786 + 275 15608234 desA2 Rv1094 - I.H.2 essential acyl-[acyl-carrier protein] desaturase KEEP 1222787..1222996 1222787 1222996 I NA NA IG1113_Rv1094-Rv1095 KEEP 1222997..1224298 1222997 1224298 + 433 15608235 phoH2 Rv1095 COG1875T I.A.4 nonessential PhoH-like protein PhoH2 (phosphate starvation-inducible protein PsiH) KEEP 1224299..1224384 1224299 1224337 I NA NA IG1114_Rv1095-Rv1096 KEEP 1224299..1224384 1224338 1224345 I NA NA IG1114_Rv1095-Rv1096 Only Marin et al 2022 KEEP 1224299..1224384 1224346 1224347 I NA NA IG1114_Rv1095-Rv1096 KEEP 1224299..1224384 1224348 1224350 I NA NA IG1114_Rv1095-Rv1096 Only Marin et al 2022 KEEP 1224299..1224384 1224351 1224355 I NA NA IG1114_Rv1095-Rv1096 KEEP 1224299..1224384 1224356 1224357 I NA NA IG1114_Rv1095-Rv1096 Only Marin et al 2022 KEEP 1224299..1224384 1224358 1224384 I NA NA IG1114_Rv1095-Rv1096 KEEP 1224385..1225260 1224385 1225260 + 291 15608236 - Rv1096 COG0726G I.A.1 nonessential glycosyl hydrolase KEEP 1225261..1225262 1225261 1225262 I NA NA IG1115_Rv1096-Rv1097c KEEP 1225263..1226144 1225263 1226144 - 293 15608237 - Rv1097c - II.C.5 nonessential hypothetical protein KEEP 1226141..1227565 1226141 1227565 - 474 15608238 fumC Rv1098c COG0114C I.B.3 essential fumarate hydratase KEEP 1227566..1227595 1227566 1227595 I NA NA IG1117_Rv1098c-Rv1099c KEEP 1227596..1228582 1227596 1228582 - 328 15608239 glpX Rv1099c COG1494G V essential fructose 1,6-bisphosphatase II KEEP 1228583..1228682 1228583 1228682 I NA NA IG1118_Rv1099c-Rv1100 KEEP 1228683..1229384 1228683 1229384 + 233 15608240 - Rv1100 - V nonessential hypothetical protein KEEP 1229385..1229390 1229385 1229390 I NA NA IG1119_Rv1100-Rv1101c KEEP 1229391..1230548 1229391 1230548 - 385 15608241 - Rv1101c COG0628R II.C.5 nonessential hypothetical protein KEEP 1230549..1230659 1230549 1230570 I NA NA IG1120_Rv1101c-Rv1102c KEEP 1230549..1230659 1230571 1230648 I NA NA IG1120_Rv1101c-Rv1102c Only Marin et al 2022 KEEP 1230549..1230659 1230649 1230659 I NA NA IG1120_Rv1101c-Rv1102c KEEP 1230660..1230971 1230660 1230971 - 103 15608242 - Rv1102c COG2337T V nonessential hypothetical protein KEEP 1230971..1231291 1230971 1231291 - 106 15608243 - Rv1103c - V nonessential hypothetical protein KEEP 1231292..1231300 1231292 1231300 I NA NA IG1122_Rv1103c-Rv1104 KEEP 1231301..1231990 1231301 1231990 + 229 15608244 - Rv1104 COG2272I II.B.5 nonessential hypothetical protein KEEP 1231991..1232310 1231991 1232310 I NA NA IG1123_Rv1104-Rv1105 KEEP 1232311..1232826 1232311 1232826 + 171 57116828 - Rv1105 COG2272I II.B.5 nonessential hypothetical protein KEEP 1232827..1232843 1232827 1232843 I NA NA IG1124_Rv1105-Rv1106c KEEP 1232844..1233956 1232844 1233956 - 370 15608246 - Rv1106c COG0451MG VI nonessential cholesterol dehydrogenase KEEP 1233957..1233965 1233957 1233965 I NA NA IG1125_Rv1106c-Rv1107c KEEP 1233966..1234223 1233966 1234223 - 85 15608247 xseB Rv1107c COG1722L II.B.2 nonessential exodeoxyribonuclease VII small subunit KEEP 1234213..1235460 1234213 1235460 - 415 15608248 xseA Rv1108c COG1570L II.B.2 nonessential exodeoxyribonuclease VII large subunit KEEP 1235457..1236095 1235457 1236095 - 212 15608249 - Rv1109c - V essential hypothetical protein KEEP 1236096..1236184 1236096 1236184 I NA NA IG1128_Rv1109c-Rv1110 KEEP 1236185..1237192 1236185 1237192 + 335 57116829 ispH Rv1110 COG0761IM II.C.3 nonessential 4-hydroxy-3-methylbut-2-enyl diphosphate reductase KEEP 1237193..1237208 1237193 1237208 I NA NA IG1129_Rv1110-Rv1111c KEEP 1237209..1238192 1237209 1238192 - 327 57116830 - Rv1111c - V essential hypothetical protein KEEP 1238193..1238254 1238193 1238254 I NA NA IG1130_Rv1111c-Rv1112 KEEP 1238255..1239328 1238255 1239328 + 357 15608252 - Rv1112 COG0012J VI nonessential translation-associated GTPase KEEP 1239329..1239415 1239329 1239415 I NA NA IG1131_Rv1112-Rv1113 KEEP 1239416..1239613 1239416 1239613 + 65 15608253 - Rv1113 - V nonessential hypothetical protein KEEP 1239610..1239984 1239610 1239984 + 124 15608254 - Rv1114 COG1487R V nonessential hypothetical protein KEEP 1239985..1240186 1239985 1240186 I NA NA IG1133_Rv1114-Rv1115 KEEP 1240187..1240885 1240187 1240885 + 232 15608255 - Rv1115 COG0791M VI nonessential hypothetical protein KEEP 1240886..1241002 1240886 1241002 I NA NA IG1134_Rv1115-Rv1116 KEEP 1241003..1241188 1241003 1241188 + 61 15608256 - Rv1116 - VI nonessential hypothetical protein KEEP 1241115..1241390 1241115 1241390 - 91 57116831 - Rv1116A - V nonessential hypothetical protein KEEP 1241391..1241632 1241391 1241632 I NA NA IG1136_Rv1116A-Rv1117 KEEP 1241633..1241956 1241633 1241956 + 107 15608257 - Rv1117 COG1359S V nonessential hypothetical protein KEEP 1241957..1241970 1241957 1241970 I NA NA IG1137_Rv1117-Rv1118c KEEP 1241971..1242831 1241971 1242831 - 286 15608258 - Rv1118c - V nonessential hypothetical protein KEEP 1242832..1242863 1242832 1242863 I NA NA IG1138_Rv1118c-Rv1119c KEEP 1242864..1243013 1242864 1243013 - 49 15608259 - Rv1119c - VI nonessential hypothetical protein KEEP 1243010..1243504 1243010 1243504 - 164 15608260 - Rv1120c COG2114T V nonessential hypothetical protein KEEP 1243505..1243706 1243505 1243706 I NA NA IG1140_Rv1120c-Rv1121 KEEP 1243707..1245107 1243707 1245107 + 466 57116832 zwf1 Rv1121 COG0364G I.B.5 nonessential glucose-6-phosphate 1-dehydrogenase KEEP 1245108..1245128 1245108 1245128 I NA NA IG1141_Rv1121-Rv1122 KEEP 1245129..1246151 1245129 1246151 + 340 15608262 gnd2 Rv1122 COG1023G I.B.5 essential 6-phosphogluconate dehydrogenase-like protein KEEP 1246144..1247052 1246144 1247052 - 302 15608263 bpoB Rv1123c COG0596R III.F nonessential peroxidase BpoB KEEP 1247053..1247126 1247053 1247126 I NA NA IG1143_Rv1123c-Rv1124 KEEP 1247127..1248077 1247127 1248077 + 316 15608264 ephC Rv1124 COG0596R III.F nonessential epoxide hydrolase EphC KEEP 1248078..1248081 1248078 1248081 I NA NA IG1144_Rv1124-Rv1125 KEEP 1248082..1249326 1248082 1249326 + 414 15608265 - Rv1125 COG0624E V nonessential hypothetical protein KEEP 1249327..1249329 1249327 1249329 I NA NA IG1145_Rv1125-Rv1126c KEEP 1249330..1249935 1249330 1249935 - 201 15608266 - Rv1126c - V essential hypothetical protein KEEP 1249932..1251404 1249932 1251404 - 490 15608267 ppdK Rv1127c COG0574G I.C.1 nonessential pyruvate phosphate dikinase KEEP 1251405..1251616 1251405 1251616 I NA NA IG1147_Rv1127c-Rv1128c KEEP 1251617..1252972 1251617 1251677 - 451 15608268 - Rv1128c - V repeat13E12 essential hypothetical protein KEEP 1251617..1252972 1251678 1251752 - 451 15608268 - Rv1128c - V repeat13E12 essential hypothetical protein Annotation + Marin et al 2022 DISCARD 1251617..1252972 1251753 1252972 - 451 15608268 - Rv1128c - V repeat13E12 essential hypothetical protein KEEP 1252973..1253073 1252973 1253073 I NA NA IG1148_Rv1128c-Rv1129c KEEP 1253074..1254534 1253074 1254534 - 486 15608269 - Rv1129c COG1396K,COG3800R I.J.1 nonessential transcriptional regulator protein KEEP 1254535..1254554 1254535 1254554 I NA NA IG1149_Rv1129c-Rv1130 KEEP 1254555..1256135 1254555 1256135 + 526 15608270 - Rv1130 COG2079R V nonessential hypothetical protein KEEP 1256132..1257313 1256132 1257313 + 393 15608271 gltA1 Rv1131 COG0372C I.B.3 nonessential methylcitrate synthase KEEP 1257314..1257324 1257314 1257324 I NA NA IG1151_Rv1131-Rv1132 KEEP 1257325..1259055 1257325 1259055 + 576 15608272 - Rv1132 - II.C.5 nonessential hypothetical protein KEEP 1259056..1259066 1259056 1259066 I NA NA IG1152_Rv1132-Rv1133c KEEP 1259067..1261346 1259067 1261346 - 759 15608273 metE Rv1133c COG0620E I.D.2 essential 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase KEEP 1261347..1261921 1261347 1261921 I NA NA IG1153_Rv1133c-Rv1134 KEEP 1261922..1262158 1261922 1262158 + 78 15608274 - Rv1134 - VI nonessential hypothetical protein KEEP 1262159..1262271 1262159 1262271 I NA NA IG1154_Rv1134-Rv1135c KEEP 1262272..1264128 1262272 1262917 - 618 57116833 PPE16 Rv1135c - IV.H PE/PPE/PGRS nonessential PPE family protein KEEP 1262272..1264128 1262918 1263031 - 618 57116833 PPE16 Rv1135c - IV.H PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1262272..1264128 1263032 1263083 - 618 57116833 PPE16 Rv1135c - IV.H PE/PPE/PGRS nonessential PPE family protein KEEP 1262272..1264128 1263084 1263190 - 618 57116833 PPE16 Rv1135c - IV.H PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1262272..1264128 1263191 1263706 - 618 57116833 PPE16 Rv1135c - IV.H PE/PPE/PGRS nonessential PPE family protein KEEP 1262272..1264128 1263707 1263760 - 618 57116833 PPE16 Rv1135c - IV.H PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1262272..1264128 1263761 1264128 - 618 57116833 PPE16 Rv1135c - IV.H PE/PPE/PGRS nonessential PPE family protein KEEP 1264129..1264313 1264129 1264313 I NA NA IG1155_Rv1135c-Rv1135A KEEP 1264314..1264556 1264314 1264556 + 80 57116834 - Rv1135A COG0183I IV.C.1 nonessential acetyl-CoA acetyltransferase KEEP 1264557..1264605 1264557 1264605 I NA NA IG1156_Rv1135A-Rv1136 KEEP 1264606..1264947 1264606 1264947 + 113 15608276 - Rv1136 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 1264948..1265086 1264948 1265086 I NA NA IG1157_Rv1136-Rv1137c KEEP 1265087..1265455 1265087 1265455 - 122 15608277 - Rv1137c - VI nonessential hypothetical protein KEEP 1265456..1265471 1265456 1265471 I NA NA IG1158_Rv1137c-Rv1138c KEEP 1265472..1266488 1265472 1266488 - 338 15608278 - Rv1138c COG0644C I.B.7 nonessential oxidoreductase KEEP 1266485..1266985 1266485 1266985 - 166 15608279 - Rv1139c COG1755S V nonessential hypothetical protein KEEP 1266986..1267346 1266986 1267218 I NA NA IG1160_Rv1139c-Rv1140 KEEP 1266986..1267346 1267219 1267269 I NA NA IG1160_Rv1139c-Rv1140 Only Marin et al 2022 KEEP 1266986..1267346 1267270 1267346 I NA NA IG1160_Rv1139c-Rv1140 KEEP 1267347..1268195 1267347 1268195 + 282 15608280 - Rv1140 COG1266R II.C.5 nonessential integral membrane protein KEEP 1268196..1268202 1268196 1268202 I NA NA IG1161_Rv1140-Rv1141c KEEP 1268203..1269009 1268203 1269009 - 268 15608281 echA11 Rv1141c COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 1269010..1269151 1269010 1269151 I NA NA IG1162_Rv1141c-Rv1142c KEEP 1269152..1269958 1269152 1269958 - 268 15608282 echA10 Rv1142c COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 1269959..1270061 1269959 1270061 I NA NA IG1163_Rv1142c-Rv1143 KEEP 1270062..1271144 1270062 1271144 + 360 15608283 mcr Rv1143 COG1804C I.A.3 nonessential alpha-methylacyl-CoA racemase KEEP 1271145..1271155 1271145 1271155 I NA NA IG1164_Rv1143-Rv1144 KEEP 1271156..1271908 1271156 1271908 + 250 15608284 - Rv1144 COG1028IQR VI essential short-chain type dehydrogenase/reductase KEEP 1271909..1272422 1271909 1272422 I NA NA IG1165_Rv1144-Rv1145 KEEP 1272423..1273334 1272423 1273334 + 303 15608285 mmpL13a Rv1145 COG2409R III.A.6 nonessential transmembrane transport protein MmpL13A KEEP 1273335..1273354 1273335 1273354 I NA NA IG1166_Rv1145-Rv1146 KEEP 1273355..1274767 1273355 1274767 + 470 15608286 mmpL13b Rv1146 COG2409R III.A.6 nonessential transmembrane transport protein MmpL13B KEEP 1274768..1274899 1274768 1274899 I NA NA IG1167_Rv1146-Rv1147 KEEP 1274900..1275550 1274900 1275550 + 216 15608287 - Rv1147 COG0500QR V nonessential hypothetical protein KEEP 1275551..1276299 1275551 1275554 I NA NA IG1168_Rv1147-Rv1148c KEEP 1275551..1276299 1275555 1275607 I NA NA IG1168_Rv1147-Rv1148c Annotation + Marin et al 2022 DISCARD 1275551..1276299 1275608 1275921 I NA NA IG1168_Rv1147-Rv1148c KEEP 1275551..1276299 1275922 1276056 I NA NA IG1168_Rv1147-Rv1148c Annotation + Marin et al 2022 DISCARD 1275551..1276299 1276057 1276288 I NA NA IG1168_Rv1147-Rv1148c KEEP 1275551..1276299 1276289 1276299 I NA NA IG1168_Rv1147-Rv1148c Annotation + Marin et al 2022 DISCARD 1276300..1277748 1276300 1277748 - 482 15608288 - Rv1148c - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 1277749..1277892 1277749 1277892 I NA NA IG1169_Rv1148c-Rv1149 repeat Annotation + Marin et al 2022 DISCARD 1277893..1278300 1277893 1278300 + 135 15608289 - Rv1149 COG3293L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1278301..1278903 1278301 1278829 I NA NA IG1170_Rv1149-Rv1151c Annotation + Marin et al 2022 DISCARD 1278301..1278903 1278830 1278903 I NA NA IG1170_Rv1149-Rv1151c KEEP 1278904..1279617 1278904 1279617 - 237 15608291 - Rv1151c COG0846K I.J.1 nonessential NAD-dependent deacetylase KEEP 1279618..1279654 1279618 1279654 I NA NA IG1171_Rv1151c-Rv1152 KEEP 1279655..1280020 1279655 1280020 + 121 15608292 - Rv1152 COG1725K I.J.1 nonessential transcriptional regulatory protein KEEP 1279998..1280846 1279998 1280846 - 282 15608293 omt Rv1153c COG3315Q I.I nonessential O-methyltransferase KEEP 1280843..1281484 1280843 1281484 - 213 15608294 - Rv1154c COG3797S VI nonessential hypothetical protein KEEP 1281429..1281872 1281429 1281872 + 147 15608295 - Rv1155 - V nonessential hypothetical protein KEEP 1281873..1282305 1281873 1281894 I NA NA IG1175_Rv1155-Rv1156 KEEP 1281873..1282305 1281895 1282022 I NA NA IG1175_Rv1155-Rv1156 Only Marin et al 2022 KEEP 1281873..1282305 1282023 1282305 I NA NA IG1175_Rv1155-Rv1156 KEEP 1282306..1282893 1282306 1282893 + 195 15608296 - Rv1156 COG0177L V nonessential hypothetical protein KEEP 1282894..1283055 1282894 1283055 I NA NA IG1176_Rv1156-Rv1157c KEEP 1283056..1284171 1283056 1283486 - 371 15608297 - Rv1157c - V nonessential hypothetical protein KEEP 1283056..1284171 1283487 1283493 - 371 15608297 - Rv1157c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 1283056..1284171 1283494 1283511 - 371 15608297 - Rv1157c - V nonessential hypothetical protein KEEP 1283056..1284171 1283512 1283548 - 371 15608297 - Rv1157c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 1283056..1284171 1283549 1283553 - 371 15608297 - Rv1157c - V nonessential hypothetical protein KEEP 1283056..1284171 1283554 1283562 - 371 15608297 - Rv1157c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 1283056..1284171 1283563 1284171 - 371 15608297 - Rv1157c - V nonessential hypothetical protein KEEP 1284172..1284178 1284172 1284178 I NA NA IG1177_Rv1157c-Rv1158c KEEP 1284179..1284862 1284179 1284406 - 227 15608298 - Rv1158c - V nonessential hypothetical protein KEEP 1284179..1284862 1284407 1284473 - 227 15608298 - Rv1158c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 1284179..1284862 1284474 1284490 - 227 15608298 - Rv1158c - V nonessential hypothetical protein KEEP 1284179..1284862 1284491 1284557 - 227 15608298 - Rv1158c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 1284179..1284862 1284558 1284862 - 227 15608298 - Rv1158c - V nonessential hypothetical protein KEEP 1284863..1284991 1284863 1284991 I NA NA IG1178_Rv1158c-Rv1159 KEEP 1284992..1286287 1284992 1286287 + 431 15608299 pimE Rv1159 - II.C.5 nonessential mannosyltransferase KEEP 1286284..1286568 1286284 1286568 - 94 57116835 phhB Rv1159A COG2154H VI nonessential pterin-4-alpha-carbinolamine dehydratase KEEP 1286569..1286594 1286569 1286594 I NA NA IG1180_Rv1159A-Rv1160 KEEP 1286595..1287020 1286595 1287020 + 141 15608300 mutT2 Rv1160 COG0494LR II.A.5 nonessential 7,8-dihydro-8-oxoguanine-triphosphatase KEEP 1287021..1287327 1287021 1287327 I NA NA IG1181_Rv1160-Rv1161 KEEP 1287328..1291026 1287328 1287558 + 1232 15608301 narG Rv1161 COG5013C I.B.6b nonessential respiratory nitrate reductase subunit alpha NarG KEEP 1287328..1291026 1287559 1287627 + 1232 15608301 narG Rv1161 COG5013C I.B.6b nonessential respiratory nitrate reductase subunit alpha NarG Only Marin et al 2022 KEEP 1287328..1291026 1287628 1287809 + 1232 15608301 narG Rv1161 COG5013C I.B.6b nonessential respiratory nitrate reductase subunit alpha NarG KEEP 1287328..1291026 1287810 1288095 + 1232 15608301 narG Rv1161 COG5013C I.B.6b nonessential respiratory nitrate reductase subunit alpha NarG Only Marin et al 2022 KEEP 1287328..1291026 1288096 1291026 + 1232 15608301 narG Rv1161 COG5013C I.B.6b nonessential respiratory nitrate reductase subunit alpha NarG KEEP 1291027..1291064 1291027 1291064 I NA NA IG1182_Rv1161-Rv1162 KEEP 1291065..1292741 1291065 1292741 + 558 15608302 narH Rv1162 COG1140C I.B.6b nonessential respiratory nitrate reductase subunit beta NarH KEEP 1292742..1292797 1292742 1292797 I NA NA IG1183_Rv1162-Rv1163 KEEP 1292798..1293403 1292798 1293001 + 201 15608303 narJ Rv1163 COG2180C I.B.6b nonessential respiratory nitrate reductase subunit delta NarJ KEEP 1292798..1293403 1293002 1293070 + 201 15608303 narJ Rv1163 COG2180C I.B.6b nonessential respiratory nitrate reductase subunit delta NarJ Only Marin et al 2022 KEEP 1292798..1293403 1293071 1293403 + 201 15608303 narJ Rv1163 COG2180C I.B.6b nonessential respiratory nitrate reductase subunit delta NarJ KEEP 1293404..1293405 1293404 1293405 I NA NA IG1184_Rv1163-Rv1164 KEEP 1293406..1294146 1293406 1294146 + 246 15608304 narI Rv1164 COG2181C I.B.6b nonessential respiratory nitrate reductase subunit gamma NarI KEEP 1294147..1294167 1294147 1294167 I NA NA IG1185_Rv1164-Rv1165 KEEP 1294168..1296054 1294168 1296054 + 628 15608305 typA Rv1165 COG1217T VI nonessential GTP-binding translation elongation factor TypA KEEP 1296055..1296151 1296055 1296151 I NA NA IG1186_Rv1165-Rv1166 KEEP 1296152..1298059 1296152 1298059 + 635 15608306 lpqW Rv1166 COG0747E II.C.1 essential lipoprotein LpqW KEEP 1298060..1298086 1298060 1298086 I NA NA IG1187_Rv1166-Rv1167c KEEP 1298087..1298692 1298087 1298692 - 201 15608307 - Rv1167c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 1298693..1298763 1298693 1298763 I NA NA IG1188_Rv1167c-Rv1168c KEEP 1298764..1299804 1298764 1299804 - 346 57116836 PPE17 Rv1168c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1299805..1299821 1299805 1299821 I NA NA IG1189_Rv1168c-Rv1169c repeat KEEP 1299822..1300124 1299822 1300124 - 100 57116837 PE11 Rv1169c - IV.C.1 PE/PPE/PGRS essential PE family protein KEEP 1300125..1300303 1300125 1300303 I NA NA IG1190_Rv1169c-Rv1170 KEEP 1300304..1301215 1300304 1301215 + 303 15608310 mshB Rv1170 COG2120S IV.D nonessential N-Acetyl-1-D-myo-Inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase mshB (GlcNAc-Ins deacetylase) KEEP 1301216..1301306 1301216 1301306 I NA NA IG1191_Rv1170-Rv1171 KEEP 1301307..1301747 1301307 1301747 + 146 57116838 - Rv1171 - V nonessential hypothetical protein KEEP 1301748..1301754 1301748 1301754 I NA NA IG1192_Rv1171-Rv1172c KEEP 1301755..1302681 1301755 1302681 - 308 57116839 PE12 Rv1172c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1302682..1302930 1302682 1302930 I NA NA IG1193_Rv1172c-Rv1173 KEEP 1302931..1305501 1302931 1305489 + 856 15608313 fbiC Rv1173 COG1060HR IV.G nonessential FO synthase KEEP 1302931..1305501 1305490 1305501 + 856 15608313 fbiC Rv1173 COG1060HR IV.G nonessential FO synthase Only Marin et al 2022 KEEP 1305502..1305668 1305502 1305665 I NA NA IG1194_Rv1173-Rv1174c Only Marin et al 2022 KEEP 1305502..1305668 1305666 1305668 I NA NA IG1194_Rv1173-Rv1174c KEEP 1305669..1306001 1305669 1306001 - 110 15608314 TB8.4 Rv1174c - VI nonessential low molecular weight T-cell antigen TB8.4 KEEP 1306002..1306201 1306002 1306201 I NA NA IG1195_Rv1174c-Rv1175c KEEP 1306202..1308226 1306202 1308226 - 674 15608315 fadH Rv1175c COG0446R,COG1902C I.A.3 nonessential NADPH dependent 2,4-dienoyl-CoA reductase KEEP 1308223..1308792 1308223 1308792 - 189 15608316 - Rv1176c COG1695K V nonessential hypothetical protein KEEP 1308793..1309004 1308793 1309004 I NA NA IG1197_Rv1176c-Rv1177 KEEP 1309005..1309331 1309005 1309331 + 108 15608317 fdxC Rv1177 COG1146C I.B.6c essential ferredoxin FdxC KEEP 1309332..1309363 1309332 1309363 I NA NA IG1198_Rv1177-Rv1178 KEEP 1309364..1310452 1309364 1310452 + 362 15608318 - Rv1178 COG0436E IV.H nonessential N-succinyldiaminopimelate aminotransferase KEEP 1310453..1310479 1310453 1310479 I NA NA IG1199_Rv1178-Rv1179c KEEP 1310480..1313299 1310480 1313128 - 939 15608319 - Rv1179c COG1061KL VI nonessential hypothetical protein KEEP 1310480..1313299 1313129 1313134 - 939 15608319 - Rv1179c COG1061KL VI nonessential hypothetical protein Only Marin et al 2022 KEEP 1310480..1313299 1313135 1313299 - 939 15608319 - Rv1179c COG1061KL VI nonessential hypothetical protein KEEP 1313300..1313724 1313300 1313383 I NA NA IG1200_Rv1179c-Rv1180 KEEP 1313300..1313724 1313384 1313385 I NA NA IG1200_Rv1179c-Rv1180 Only Marin et al 2022 KEEP 1313300..1313724 1313386 1313388 I NA NA IG1200_Rv1179c-Rv1180 KEEP 1313300..1313724 1313389 1313394 I NA NA IG1200_Rv1179c-Rv1180 Only Marin et al 2022 KEEP 1313300..1313724 1313395 1313724 I NA NA IG1200_Rv1179c-Rv1180 KEEP 1313725..1315191 1313725 1315191 + 488 15608320 pks3 Rv1180 COG3321Q I.I nonessential polyketide beta-ketoacyl synthase PKS3 KEEP 1315192..1315233 1315192 1315233 I NA NA IG1201_Rv1180-Rv1181 KEEP 1315234..1319982 1315234 1319184 + 1582 15608321 pks4 Rv1181 COG3321Q I.I nonessential polyketide beta-ketoacyl synthase PKS4 KEEP 1315234..1319982 1319185 1319262 + 1582 15608321 pks4 Rv1181 COG3321Q I.I nonessential polyketide beta-ketoacyl synthase PKS4 Marin et al 2022 + homoplasy analysis DISCARD 1315234..1319982 1319263 1319982 + 1582 15608321 pks4 Rv1181 COG3321Q I.I nonessential polyketide beta-ketoacyl synthase PKS4 KEEP 1319983..1320034 1319983 1320034 I NA NA IG1202_Rv1181-Rv1182 KEEP 1320035..1321453 1320035 1321453 + 472 15608322 papA3 Rv1182 COG1020Q I.I essential polyketide synthase associated protein PapA3 KEEP 1321454..1321519 1321454 1321519 I NA NA IG1203_Rv1182-Rv1183 KEEP 1321520..1324528 1321520 1324528 + 1002 15608323 mmpL10 Rv1183 COG2409R II.C.4 essential transmembrane transport protein MmpL10 KEEP 1324529..1324531 1324529 1324531 I NA NA IG1204_Rv1183-Rv1184c KEEP 1324532..1325611 1324532 1325611 - 359 15608324 - Rv1184c COG3008R VI essential hypothetical protein KEEP 1325612..1325775 1325612 1325775 I NA NA IG1205_Rv1184c-Rv1185c KEEP 1325776..1327512 1325776 1326282 - 578 15608325 fadD21 Rv1185c COG0318IQ I.A.3 essential acyl-CoA synthetase KEEP 1325776..1327512 1326283 1326333 - 578 15608325 fadD21 Rv1185c COG0318IQ I.A.3 essential acyl-CoA synthetase Only Marin et al 2022 KEEP 1325776..1327512 1326334 1327512 - 578 15608325 fadD21 Rv1185c COG0318IQ I.A.3 essential acyl-CoA synthetase KEEP 1327513..1327688 1327513 1327688 I NA NA IG1206_Rv1185c-Rv1186c KEEP 1327689..1329305 1327689 1329305 - 538 15608326 - Rv1186c COG2508TQ V essential hypothetical protein KEEP 1329306..1329389 1329306 1329389 I NA NA IG1207_Rv1186c-Rv1187 KEEP 1329390..1331021 1329390 1331021 + 543 15608327 rocA Rv1187 COG1012C I.A.2 essential pyrroline-5-carboxylate dehydrogenase ROCA KEEP 1331021..1332010 1331021 1332010 + 329 15608328 - Rv1188 COG0506E I.B.7 essential proline dehydrogenase KEEP 1332011..1332091 1332011 1332091 I NA NA IG1209_Rv1188-Rv1189 KEEP 1332092..1332964 1332092 1332964 + 290 15608329 sigI Rv1189 COG1595K II.A.7 nonessential RNA polymerase sigma factor SigI KEEP 1332965..1332979 1332965 1332979 I NA NA IG1210_Rv1189-Rv1190 KEEP 1332980..1333858 1332980 1333858 + 292 15608330 - Rv1190 COG0596R V nonessential hypothetical protein KEEP 1333859..1333930 1333859 1333930 I NA NA IG1211_Rv1190-Rv1191 KEEP 1333931..1334845 1333931 1334845 + 304 15608331 - Rv1191 COG0596R V nonessential hypothetical protein KEEP 1334846..1334926 1334846 1334926 I NA NA IG1212_Rv1191-Rv1192 KEEP 1334927..1335754 1334927 1335475 + 275 15608332 - Rv1192 COG0596R VI essential hypothetical protein KEEP 1334927..1335754 1335476 1335513 + 275 15608332 - Rv1192 COG0596R VI essential hypothetical protein Only Marin et al 2022 KEEP 1334927..1335754 1335514 1335754 + 275 15608332 - Rv1192 COG0596R VI essential hypothetical protein KEEP 1335755..1335793 1335755 1335793 I NA NA IG1213_Rv1192-Rv1193 KEEP 1335794..1337215 1335794 1337215 + 473 15608333 fadD36 Rv1193 COG0318IQ I.A.3 essential acyl-CoA synthetase KEEP 1337216..1337247 1337216 1337247 I NA NA IG1214_Rv1193-Rv1194c KEEP 1337248..1338513 1337248 1338513 - 421 15608334 - Rv1194c COG2508TQ V essential hypothetical protein KEEP 1338514..1339002 1338514 1339002 I NA NA IG1215_Rv1194c-Rv1195 KEEP 1339003..1339302 1339003 1339302 + 99 57116840 PE13 Rv1195 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1339303..1339348 1339303 1339342 I NA NA IG1216_Rv1195-Rv1196 repeat KEEP 1339303..1339348 1339343 1339348 I NA NA IG1216_Rv1195-Rv1196 repeat Annotation + Marin et al 2022 DISCARD 1339349..1340524 1339349 1339839 + 391 57116841 PPE18 Rv1196 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1339349..1340524 1339840 1339885 + 391 57116841 PPE18 Rv1196 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + homoplasy analysis DISCARD 1339349..1340524 1339886 1340001 + 391 57116841 PPE18 Rv1196 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1339349..1340524 1340002 1340005 + 391 57116841 PPE18 Rv1196 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1339349..1340524 1340006 1340397 + 391 57116841 PPE18 Rv1196 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1339349..1340524 1340398 1340490 + 391 57116841 PPE18 Rv1196 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1339349..1340524 1340491 1340524 + 391 57116841 PPE18 Rv1196 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1340525..1340658 1340525 1340658 I NA NA IG1217_Rv1196-Rv1197 Annotation + Marin et al 2022 DISCARD 1340659..1340955 1340659 1340955 + 98 15608337 esxK Rv1197 - VI nonessential Esat-6 like protein esxK (Esat-6 like protein 3) Marin et al 2022 + homoplasy analysis DISCARD 1340956..1341005 1340956 1341005 I NA NA IG1218_Rv1197-Rv1198 Only Marin et al 2022 KEEP 1341006..1341290 1341006 1341290 + 94 15608338 esxL Rv1198 - VI nonessential putative ESAT-6 like protein ESXL (ESAT-6 like protein 4) Marin et al 2022 + homoplasy analysis DISCARD 1341291..1341357 1341291 1341357 I NA NA IG1219_Rv1198-Rv1199c Annotation + Marin et al 2022 DISCARD 1341358..1342605 1341358 1342605 - 415 15608339 - Rv1199c COG3328L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1342606..1342941 1342606 1342739 I NA NA IG1220_Rv1199c-Rv1200 Annotation + Marin et al 2022 DISCARD 1342606..1342941 1342740 1342941 I NA NA IG1220_Rv1199c-Rv1200 KEEP 1342942..1344219 1342942 1344219 + 425 15608340 - Rv1200 COG0477GEPR III.A.3 nonessential integral membrane transport protein KEEP 1344216..1345169 1344216 1345169 - 317 15608341 - Rv1201c COG2171E IV.H essential transferase KEEP 1345170..1345259 1345170 1345259 I NA NA IG1222_Rv1201c-Rv1202 KEEP 1345260..1346324 1345260 1346324 + 354 57116842 dapE Rv1202 COG0624E I.D.2 essential dipeptidase KEEP 1346321..1346905 1346321 1346905 - 194 15608343 - Rv1203c - VI nonessential hypothetical protein KEEP 1346906..1346935 1346906 1346935 I NA NA IG1224_Rv1203c-Rv1204c KEEP 1346936..1348624 1346936 1348624 - 562 15608344 - Rv1204c COG0488R V essential hypothetical protein KEEP 1348625..1348718 1348625 1348718 I NA NA IG1225_Rv1204c-Rv1205 KEEP 1348719..1349282 1348719 1349282 + 187 15608345 - Rv1205 COG1611R V nonessential hypothetical protein KEEP 1349283..1349331 1349283 1349331 I NA NA IG1226_Rv1205-Rv1206 KEEP 1349332..1351125 1349332 1351125 + 597 15608346 fadD6 Rv1206 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1351126..1351190 1351126 1351190 I NA NA IG1227_Rv1206-Rv1207 KEEP 1351191..1352147 1351191 1351193 + 318 15608347 folP2 Rv1207 COG0294H I.G.2 nonessential dihydropteroate synthase 2 FolP2 KEEP 1351191..1352147 1351194 1351283 + 318 15608347 folP2 Rv1207 COG0294H I.G.2 nonessential dihydropteroate synthase 2 FolP2 Marin et al 2022 + homoplasy analysis DISCARD 1351191..1352147 1351284 1352147 + 318 15608347 folP2 Rv1207 COG0294H I.G.2 nonessential dihydropteroate synthase 2 FolP2 KEEP 1352144..1353118 1352144 1353118 + 324 15608348 - Rv1208 COG0463M V essential hypothetical protein KEEP 1353119..1353156 1353119 1353156 I NA NA IG1229_Rv1208-Rv1209 KEEP 1353157..1353525 1353157 1353525 + 122 15608349 - Rv1209 - V nonessential hypothetical protein KEEP 1353522..1354136 1353522 1354136 + 204 15608350 tagA Rv1210 COG2818L II.A.5 nonessential DNA-3-methyladenine glycosylase I KEEP 1354137..1354242 1354137 1354242 I NA NA IG1231_Rv1210-Rv1211 KEEP 1354243..1354470 1354243 1354470 + 75 15608351 - Rv1211 - V essential hypothetical protein KEEP 1354471..1354497 1354471 1354497 I NA NA IG1232_Rv1211-Rv1212c KEEP 1354498..1355661 1354498 1355661 - 387 15608352 - Rv1212c COG0438M IV.H nonessential putative glycosyl transferase KEEP 1355662..1355835 1355662 1355835 I NA NA IG1233_Rv1212c-Rv1213 KEEP 1355836..1357050 1355836 1357050 + 404 15608353 glgC Rv1213 COG0448G I.C.1 nonessential glucose-1-phosphate adenylyltransferase KEEP 1357051..1357292 1357051 1357059 I NA NA IG1234_Rv1213-Rv1214c KEEP 1357051..1357292 1357060 1357129 I NA NA IG1234_Rv1213-Rv1214c Annotation + Marin et al 2022 DISCARD 1357051..1357292 1357130 1357246 I NA NA IG1234_Rv1213-Rv1214c KEEP 1357051..1357292 1357247 1357292 I NA NA IG1234_Rv1213-Rv1214c Annotation + Marin et al 2022 DISCARD 1357293..1357625 1357293 1357302 - 110 57116843 PE14 Rv1214c - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 1357293..1357625 1357303 1357625 - 110 57116843 PE14 Rv1214c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1357626..1357758 1357626 1357758 I NA NA IG1235_Rv1214c-Rv1215c KEEP 1357759..1359444 1357759 1359444 - 561 15608355 - Rv1215c COG2936R V essential hypothetical protein KEEP 1359445..1359471 1359445 1359471 I NA NA IG1236_Rv1215c-Rv1216c KEEP 1359472..1360146 1359472 1360146 - 224 15608356 - Rv1216c COG2020O II.C.5 nonessential integral membrane protein KEEP 1360147..1360154 1360147 1360154 I NA NA IG1237_Rv1216c-Rv1217c KEEP 1360155..1361801 1360155 1361801 - 548 15608357 - Rv1217c COG3559M II.C.5 nonessential tetronasin-transport integral membrane protein ABC transporter KEEP 1361798..1362733 1361798 1362733 - 311 15608358 - Rv1218c COG1131V III.A nonessential tetronasin-transport ATP-binding protein ABC transporter KEEP 1362723..1363361 1362723 1363361 - 212 15608359 - Rv1219c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 1363362..1363502 1363362 1363469 I NA NA IG1240_Rv1219c-Rv1220c KEEP 1363362..1363502 1363470 1363471 I NA NA IG1240_Rv1219c-Rv1220c Only Marin et al 2022 KEEP 1363362..1363502 1363472 1363502 I NA NA IG1240_Rv1219c-Rv1220c KEEP 1363503..1364150 1363503 1364150 - 215 15608360 - Rv1220c COG4122R IV.H nonessential methyltransferase KEEP 1364151..1364412 1364151 1364412 I NA NA IG1241_Rv1220c-Rv1221 KEEP 1364413..1365186 1364413 1365186 + 257 15608361 sigE Rv1221 COG1595K II.A.7 nonessential RNA polymerase sigma factor SigE KEEP 1365187..1365343 1365187 1365343 I NA NA IG1242_Rv1221-Rv1222 KEEP 1365344..1365808 1365344 1365808 + 154 15608362 - Rv1222 - V nonessential hypothetical protein KEEP 1365809..1365874 1365809 1365874 I NA NA IG1243_Rv1222-Rv1223 KEEP 1365875..1367461 1365875 1367461 + 528 57116844 htrA Rv1223 COG0265O II.B.3 essential serine protease HtrA KEEP 1367463..1367858 1367463 1367858 + 131 15608364 tatB Rv1224 COG1826U VII essential sec-independent translocase KEEP 1367859..1367890 1367859 1367890 I NA NA IG1245_Rv1224-Rv1225c KEEP 1367891..1368721 1367891 1368721 - 276 15608365 - Rv1225c COG0647G V nonessential hypothetical protein KEEP 1368722..1368831 1368722 1368831 I NA NA IG1246_Rv1225c-Rv1226c KEEP 1368832..1370295 1368832 1370295 - 487 15608366 - Rv1226c COG3428S II.C.5 nonessential hypothetical protein KEEP 1370292..1370825 1370292 1370825 - 177 15608367 - Rv1227c COG3402S II.C.5 nonessential hypothetical protein KEEP 1370826..1370919 1370826 1370919 I NA NA IG1248_Rv1227c-Rv1228 KEEP 1370920..1371477 1370920 1371477 + 185 15608368 lpqX Rv1228 - II.C.1 nonessential lipoprotein LpqX KEEP 1371478..1371776 1371478 1371776 I NA NA IG1249_Rv1228-Rv1229c KEEP 1371777..1372949 1371777 1372949 - 390 15608369 mrp Rv1229c COG0489D VI essential MRP family ATP-binding protein KEEP 1372950..1372961 1372950 1372961 I NA NA IG1250_Rv1229c-Rv1230c KEEP 1372962..1374197 1372962 1374197 - 411 15608370 - Rv1230c COG2951M II.C.5 nonessential hypothetical protein KEEP 1374198..1374321 1374198 1374321 I NA NA IG1251_Rv1230c-Rv1231c KEEP 1374322..1374864 1374322 1374864 - 180 15608371 - Rv1231c COG4420S II.C.5 nonessential hypothetical protein KEEP 1374861..1376168 1374861 1376168 - 435 15608372 - Rv1232c COG2239P V essential hypothetical protein KEEP 1376169..1376229 1376169 1376229 I NA NA IG1253_Rv1232c-Rv1233c KEEP 1376230..1376826 1376230 1376826 - 198 15608373 - Rv1233c - V nonessential hypothetical protein KEEP 1376827..1376975 1376827 1376975 I NA NA IG1254_Rv1233c-Rv1234 KEEP 1376976..1377503 1376976 1377503 + 175 15608374 - Rv1234 - II.C.5 nonessential hypothetical protein KEEP 1377504..1377523 1377504 1377523 I NA NA IG1255_Rv1234-Rv1235 KEEP 1377524..1378930 1377524 1378930 + 468 15608375 lpqY Rv1235 COG1653G II.C.1 essential sugar-binding lipoprotein LpqY KEEP 1378927..1379850 1378927 1379850 + 307 15608376 sugA Rv1236 COG1175G III.A.3 essential sugar-transport integral membrane protein ABC transporter SugA KEEP 1379851..1379854 1379851 1379854 I NA NA IG1257_Rv1236-Rv1237 KEEP 1379855..1380679 1379855 1380679 + 274 15608377 sugB Rv1237 COG0395G III.A.3 essential sugar-transport integral membrane protein ABC transporter SugB KEEP 1380680..1380683 1380680 1380683 I NA NA IG1258_Rv1237-Rv1238 KEEP 1380684..1381865 1380684 1381865 + 393 15608378 sugC Rv1238 COG3839G III.A.3 essential sugar-transport ATP-binding protein ABC transporter SugC KEEP 1381866..1381941 1381866 1381941 I NA NA IG1259_Rv1238-Rv1239c KEEP 1381942..1383042 1381942 1383042 - 366 15608379 corA Rv1239c COG0598P III.A.2 nonessential magnesium/cobalt transporter CorA KEEP 1383043..1383212 1383043 1383212 I NA NA IG1260_Rv1239c-Rv1240 KEEP 1383213..1384202 1383213 1384202 + 329 15608380 mdh Rv1240 COG0039C I.B.3 nonessential malate dehydrogenase KEEP 1384203..1384277 1384203 1384277 I NA NA IG1261_Rv1240-Rv1241 KEEP 1384278..1384538 1384278 1384538 + 86 15608381 - Rv1241 - V nonessential hypothetical protein KEEP 1384535..1384966 1384535 1384966 + 143 15608382 - Rv1242 - V nonessential hypothetical protein KEEP 1384967..1384988 1384967 1384988 I NA NA IG1263_Rv1242-Rv1243c KEEP 1384989..1386677 1384989 1385095 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1385096 1385437 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1385438 1385571 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1385572 1385580 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1385581 1385585 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1385586 1385667 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1385668 1385668 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1385669 1385672 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1385673 1386007 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1386008 1386036 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386037 1386072 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1386073 1386081 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386082 1386111 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1386112 1386113 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386114 1386117 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1386118 1386121 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386122 1386124 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1386125 1386129 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386130 1386135 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1386136 1386140 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386141 1386153 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1386154 1386214 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386215 1386284 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1384989..1386677 1386285 1386359 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386360 1386450 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + homoplasy analysis DISCARD 1384989..1386677 1386451 1386501 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1384989..1386677 1386502 1386677 - 562 57116845 PE_PGRS23 Rv1243c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1386678..1386856 1386678 1386856 I NA NA IG1264_Rv1243c-Rv1244 KEEP 1386857..1387717 1386857 1387717 + 286 15608384 lpqZ Rv1244 COG1732M II.C.1 essential lipoprotein LpqZ KEEP 1387718..1387797 1387718 1387797 I NA NA IG1265_Rv1244-Rv1245c KEEP 1387798..1388628 1387798 1388109 - 276 15608385 - Rv1245c COG1028IQR VI nonessential short-chain type dehydrogenase/reductase KEEP 1387798..1388628 1388110 1388170 - 276 15608385 - Rv1245c COG1028IQR VI nonessential short-chain type dehydrogenase/reductase Only Marin et al 2022 KEEP 1387798..1388628 1388171 1388628 - 276 15608385 - Rv1245c COG1028IQR VI nonessential short-chain type dehydrogenase/reductase KEEP 1388629..1388684 1388629 1388684 I NA NA IG1266_Rv1245c-Rv1246c KEEP 1388685..1388978 1388685 1388978 - 97 15608386 - Rv1246c COG2026JD V nonessential hypothetical protein KEEP 1388975..1389244 1388975 1389244 - 89 15608387 - Rv1247c COG2161D V nonessential hypothetical protein KEEP 1389245..1389356 1389245 1389356 I NA NA IG1268_Rv1247c-Rv1248c KEEP 1389357..1393052 1389357 1393052 - 1231 161352467 kgd Rv1248c COG0508C,COG0567C I.B.3 essential alpha-ketoglutarate decarboxylase KEEP 1393053..1393193 1393053 1393193 I NA NA IG1269_Rv1248c-Rv1249c KEEP 1393194..1393982 1393194 1393982 - 262 15608389 - Rv1249c - II.C.5 nonessential hypothetical protein KEEP 1393983..1394178 1393983 1394178 I NA NA IG1270_Rv1249c-Rv1250 KEEP 1394179..1395918 1394179 1395918 + 579 15608390 - Rv1250 COG0477GEPR III.A.6 nonessential drug-transport integral membrane protein KEEP 1395821..1399240 1395821 1399240 - 1139 15608391 - Rv1251c COG1112L,COG2251R V nonessential hypothetical protein KEEP 1399241..1399295 1399241 1399295 I NA NA IG1272_Rv1251c-Rv1252c KEEP 1399296..1399904 1399296 1399904 - 202 15608392 lprE Rv1252c - II.C.1 nonessential lipoprotein LprE KEEP 1399905..1399969 1399905 1399969 I NA NA IG1273_Rv1252c-Rv1253 KEEP 1399970..1401661 1399970 1401661 + 563 15608393 deaD Rv1253 COG0513LKJ II.A.7 nonessential cold-shock DEAD-box protein A KEEP 1401658..1402809 1401658 1402809 + 383 15608394 - Rv1254 COG1835I IV.H essential acyltransferase KEEP 1402778..1403386 1402778 1403386 - 202 15608395 - Rv1255c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 1403386..1404603 1403386 1404603 - 405 15608396 cyp130 Rv1256c COG2124Q IV.F nonessential ytochrome P450 130 CYP130 KEEP 1404604..1404716 1404604 1404716 I NA NA IG1277_Rv1256c-Rv1257c KEEP 1404717..1406084 1404717 1406084 - 455 15608397 - Rv1257c COG0277C I.B.7 nonessential oxidoreductase KEEP 1406081..1407340 1406081 1407340 - 419 15608398 - Rv1258c COG0477GEPR III.A.6 nonessential integral membrane transport protein KEEP 1407339..1408238 1407339 1408238 + 299 15608399 - Rv1259 COG1573L V nonessential hypothetical protein KEEP 1408240..1409358 1408240 1408677 + 372 15608400 - Rv1260 COG0654HC I.B.7 nonessential hypothetical protein KEEP 1408240..1409358 1408678 1408729 + 372 15608400 - Rv1260 COG0654HC I.B.7 nonessential hypothetical protein Only Marin et al 2022 KEEP 1408240..1409358 1408730 1409358 + 372 15608400 - Rv1260 COG0654HC I.B.7 nonessential hypothetical protein KEEP 1409359..1409483 1409359 1409483 I NA NA IG1281_Rv1260-Rv1261c KEEP 1409484..1409933 1409484 1409933 - 149 15608401 - Rv1261c - V nonessential hypothetical protein KEEP 1409934..1409937 1409934 1409937 I NA NA IG1282_Rv1261c-Rv1262c KEEP 1409938..1410372 1409938 1410372 - 144 15608402 - Rv1262c COG0537FGR VI nonessential HIT-like protein KEEP 1410373..1410430 1410373 1410430 I NA NA IG1283_Rv1262c-Rv1263 KEEP 1410431..1411819 1410431 1411819 + 462 15608403 amiB2 Rv1263 COG0154J IV.I nonessential amidase KEEP 1411820..1411893 1411820 1411893 I NA NA IG1284_Rv1263-Rv1264 KEEP 1411894..1413087 1411894 1413087 + 397 15608404 - Rv1264 COG2114T IV.I nonessential adenylyl cyclase KEEP 1413088..1413259 1413088 1413259 I NA NA IG1285_Rv1264-Rv1265 KEEP 1413260..1413940 1413260 1413940 + 226 15608405 - Rv1265 - VI nonessential hypothetical protein KEEP 1413941..1413959 1413941 1413959 I NA NA IG1286_Rv1265-Rv1266c KEEP 1413960..1415840 1413960 1414619 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H KEEP 1413960..1415840 1414620 1414621 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H Marin et al 2022 + homoplasy analysis DISCARD 1413960..1415840 1414622 1414627 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H KEEP 1413960..1415840 1414628 1414629 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H Marin et al 2022 + homoplasy analysis DISCARD 1413960..1415840 1414630 1414642 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H KEEP 1413960..1415840 1414643 1414644 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H Only Marin et al 2022 KEEP 1413960..1415840 1414645 1414651 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H KEEP 1413960..1415840 1414652 1414653 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H Marin et al 2022 + homoplasy analysis DISCARD 1413960..1415840 1414654 1415840 - 626 15608406 pknH Rv1266c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase H KEEP 1415841..1416180 1415841 1416180 I NA NA IG1287_Rv1266c-Rv1267c KEEP 1416181..1417347 1416181 1417347 - 388 15608407 embR Rv1267c COG1716T,COG3629T I.J.1 DR-emb nonessential transcriptional regulatory protein EMBR KEEP 1417348..1417657 1417348 1417657 I NA NA IG1288_Rv1267c-Rv1268c DR-emb KEEP 1417658..1418356 1417658 1418356 - 232 15608408 - Rv1268c - VI nonessential hypothetical protein KEEP 1418357..1418578 1418357 1418578 I NA NA IG1289_Rv1268c-Rv1269c KEEP 1418579..1418953 1418579 1418953 - 124 15608409 - Rv1269c - VI nonessential hypothetical protein KEEP 1418954..1419013 1418954 1419013 I NA NA IG1290_Rv1269c-Rv1270c KEEP 1419014..1419748 1419014 1419748 - 244 15608410 lprA Rv1270c - II.C.1 nonessential lipoprotein LprA KEEP 1419749..1419960 1419749 1419960 I NA NA IG1291_Rv1270c-Rv1271c KEEP 1419961..1420302 1419961 1420302 - 113 15608411 - Rv1271c - V nonessential hypothetical protein KEEP 1420303..1420409 1420303 1420409 I NA NA IG1292_Rv1271c-Rv1272c KEEP 1420410..1422305 1420410 1422305 - 631 15608412 - Rv1272c COG1132V II.C.5 essential drugs-transport transmembrane ATP-binding protein ABC transporter KEEP 1422302..1424050 1422302 1424050 - 582 15608413 - Rv1273c COG1132V II.C.5 nonessential drugs-transport transmembrane ATP-binding protein ABC transporter KEEP 1424051..1424196 1424051 1424196 I NA NA IG1294_Rv1273c-Rv1274 KEEP 1424197..1424754 1424197 1424754 + 185 15608414 lprB Rv1274 - II.C.1 essential lipoprotein LprB KEEP 1424751..1425293 1424751 1425293 + 180 15608415 lprC Rv1275 - II.C.1 nonessential lipoprotein LprC KEEP 1425294..1425437 1425294 1425437 I NA NA IG1296_Rv1275-Rv1276c KEEP 1425438..1425914 1425438 1425914 - 158 15608416 - Rv1276c COG2062T V nonessential hypothetical protein KEEP 1425915..1426163 1425915 1426163 I NA NA IG1297_Rv1276c-Rv1277 KEEP 1426164..1427417 1426164 1427417 + 417 15608417 - Rv1277 COG0420L V nonessential hypothetical protein KEEP 1427414..1430041 1427414 1430041 + 875 15608418 - Rv1278 COG0419L,COG4717S VI essential hypothetical protein KEEP 1430042..1430061 1430042 1430061 I NA NA IG1299_Rv1278-Rv1279 KEEP 1430062..1431648 1430062 1431648 + 528 15608419 - Rv1279 COG2303E I.B.7 nonessential dehydrogenase FAD flavoprotein GMC oxidoreductase KEEP 1431649..1431664 1431649 1431664 I NA NA IG1300_Rv1279-Rv1280c KEEP 1431665..1433440 1431665 1433440 - 591 15608420 oppA Rv1280c COG0747E III.A.1 nonessential periplasmic oligopeptide-binding lipoprotein OppA KEEP 1433433..1435271 1433433 1435271 - 612 15608421 oppD Rv1281c COG1123R III.A.1 nonessential oligopeptide-transport ATP-binding protein ABC transporter OppD KEEP 1435268..1436143 1435268 1436143 - 291 15608422 oppC Rv1282c COG1173EP III.A.1 nonessential oligopeptide-transport integral membrane protein ABC transporter OppC KEEP 1436140..1437117 1436140 1437117 - 325 15608423 oppB Rv1283c COG0601EP III.A.1 nonessential oligopeptide-transport integral membrane protein ABC transporter OppB KEEP 1437118..1437323 1437118 1437323 I NA NA IG1304_Rv1283c-Rv1284 KEEP 1437324..1437815 1437324 1437815 + 163 15608424 - Rv1284 COG0288P V essential hypothetical protein KEEP 1437816..1437908 1437816 1437908 I NA NA IG1305_Rv1284-Rv1285 KEEP 1437909..1438907 1437909 1438907 + 332 15608425 cysD Rv1285 COG0175EH I.C.5 essential sulfate adenylyltransferase subunit 2 KEEP 1438907..1440751 1438907 1440751 + 614 15608426 cysN Rv1286 COG0529P,COG2895P I.C.5 essential bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein KEEP 1440752..1440804 1440752 1440804 I NA NA IG1307_Rv1286-Rv1287 KEEP 1440805..1441290 1440805 1441290 + 161 15608427 - Rv1287 COG1959K V nonessential hypothetical protein KEEP 1441291..1441347 1441291 1441347 I NA NA IG1308_Rv1287-Rv1288 KEEP 1441348..1442718 1441348 1441363 + 456 15608428 - Rv1288 COG0627R,COG1388M V nonessential hypothetical protein KEEP 1441348..1442718 1441364 1441725 + 456 15608428 - Rv1288 COG0627R,COG1388M V nonessential hypothetical protein Only Marin et al 2022 KEEP 1441348..1442718 1441726 1442718 + 456 15608428 - Rv1288 COG0627R,COG1388M V nonessential hypothetical protein KEEP 1442719..1442766 1442719 1442766 I NA NA IG1309_Rv1288-Rv1289 KEEP 1442767..1443399 1442767 1443399 + 210 15608429 - Rv1289 - VI nonessential hypothetical protein KEEP 1443400..1443481 1443400 1443426 I NA NA IG1310_Rv1289-Rv1290c KEEP 1443400..1443481 1443427 1443428 I NA NA IG1310_Rv1289-Rv1290c Only Marin et al 2022 KEEP 1443400..1443481 1443429 1443432 I NA NA IG1310_Rv1289-Rv1290c KEEP 1443400..1443481 1443433 1443481 I NA NA IG1310_Rv1289-Rv1290c Only Marin et al 2022 KEEP 1443482..1445047 1443482 1443486 - 521 15608430 - Rv1290c COG4325S VI nonessential hypothetical protein Only Marin et al 2022 KEEP 1443482..1445047 1443487 1445047 - 521 15608430 - Rv1290c COG4325S VI nonessential hypothetical protein KEEP 1445048..1445057 1445048 1445057 I NA NA IG1311_Rv1290c-Rv1290A KEEP 1445058..1445372 1445058 1445085 + 104 57116846 - Rv1290A - V nonessential hypothetical protein KEEP 1445058..1445372 1445086 1445121 + 104 57116846 - Rv1290A - V nonessential hypothetical protein Only Marin et al 2022 KEEP 1445058..1445372 1445122 1445372 + 104 57116846 - Rv1290A - V nonessential hypothetical protein KEEP 1445373..1445498 1445373 1445498 I NA NA IG1312_Rv1290A-Rv1291c KEEP 1445499..1445834 1445499 1445834 - 111 15608431 - Rv1291c - V nonessential hypothetical protein KEEP 1445835..1446378 1445835 1446378 I NA NA IG1313_Rv1291c-Rv1292 KEEP 1446379..1448031 1446379 1448031 + 550 15608432 argS Rv1292 COG0018J II.A.3 essential arginyl-tRNA synthetase KEEP 1448028..1449371 1448028 1449371 + 447 15608433 lysA Rv1293 COG0019E I.D.2 essential diaminopimelate decarboxylase LysA KEEP 1449372..1449374 1449372 1449374 I NA NA IG1315_Rv1293-Rv1294 KEEP 1449375..1450700 1449375 1450700 + 441 15608434 thrA Rv1294 COG0460E I.D.2 essential homoserine dehydrogenase KEEP 1450697..1451779 1450697 1451771 + 360 15608435 thrC Rv1295 COG0498E I.D.2 essential threonine synthase KEEP 1450697..1451779 1451772 1451779 + 360 15608435 thrC Rv1295 COG0498E I.D.2 essential threonine synthase Only Marin et al 2022 KEEP 1451780..1451996 1451780 1451996 I NA NA IG1317_Rv1295-Rv1296 Only Marin et al 2022 KEEP 1451997..1452947 1451997 1452003 + 316 15608436 thrB Rv1296 COG0083E I.D.2 essential homoserine kinase Only Marin et al 2022 KEEP 1451997..1452947 1452004 1452947 + 316 15608436 thrB Rv1296 COG0083E I.D.2 essential homoserine kinase KEEP 1452948..1453203 1452948 1453203 I NA NA IG1318_Rv1296-Rv1297 KEEP 1453204..1455012 1453204 1455012 + 602 15608437 rho Rv1297 COG1158K II.A.7 essential transcription termination factor Rho KEEP 1455013..1455162 1455013 1455162 I NA NA IG1319_Rv1297-Rv1298 KEEP 1455163..1455405 1455163 1455405 + 80 15608438 rpmE Rv1298 COG0254J II.A.1 essential 50S ribosomal protein L31 KEEP 1455406..1455494 1455406 1455494 I NA NA IG1320_Rv1298-Rv1299 KEEP 1455495..1456568 1455495 1456568 + 357 15608439 prfA Rv1299 COG0216J II.A.6 essential peptide chain release factor 1 KEEP 1456565..1457542 1456565 1456571 + 325 15608440 hemK Rv1300 COG2890J I.G.12 essential hypothetical protein KEEP 1456565..1457542 1456572 1456625 + 325 15608440 hemK Rv1300 COG2890J I.G.12 essential hypothetical protein Only Marin et al 2022 KEEP 1456565..1457542 1456626 1457458 + 325 15608440 hemK Rv1300 COG2890J I.G.12 essential hypothetical protein KEEP 1456565..1457542 1457459 1457542 + 325 15608440 hemK Rv1300 COG2890J I.G.12 essential hypothetical protein Only Marin et al 2022 KEEP 1457543..1457557 1457543 1457557 I NA NA IG1322_Rv1300-Rv1301 Only Marin et al 2022 KEEP 1457558..1458211 1457558 1457568 + 217 15608441 - Rv1301 COG0009J V essential hypothetical protein Only Marin et al 2022 KEEP 1457558..1458211 1457569 1458211 + 217 15608441 - Rv1301 COG0009J V essential hypothetical protein KEEP 1458212..1458294 1458212 1458294 I NA NA IG1323_Rv1301-Rv1302 KEEP 1458295..1459509 1458295 1459509 + 404 15608442 rfe Rv1302 COG0472M II.C.2 nonessential undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase rfe (UDP-GlcNAc transferase) KEEP 1459510..1459765 1459510 1459765 I NA NA IG1324_Rv1302-Rv1303 KEEP 1459766..1460251 1459766 1460251 + 161 15608443 - Rv1303 - V essential hypothetical protein KEEP 1460244..1460996 1460244 1460996 + 250 15608444 atpB Rv1304 COG0356C I.B.8 essential F0F1 ATP synthase subunit A KEEP 1460997..1461044 1460997 1461044 I NA NA IG1326_Rv1304-Rv1305 KEEP 1461045..1461290 1461045 1461290 + 81 15608445 atpE Rv1305 COG0636C I.B.8 essential F0F1 ATP synthase subunit C KEEP 1461291..1461320 1461291 1461320 I NA NA IG1327_Rv1305-Rv1306 KEEP 1461321..1461836 1461321 1461836 + 171 15608446 atpF Rv1306 COG0711C I.B.8 essential F0F1 ATP synthase subunit B KEEP 1461837..1461842 1461837 1461842 I NA NA IG1328_Rv1306-Rv1307 KEEP 1461843..1463183 1461843 1463183 + 446 15608447 atpH Rv1307 COG0711C,COG0712C I.B.8 essential F0F1 ATP synthase subunit delta KEEP 1463184..1463227 1463184 1463227 I NA NA IG1329_Rv1307-Rv1308 KEEP 1463228..1464877 1463228 1464877 + 549 15608448 atpA Rv1308 COG0056C I.B.8 essential F0F1 ATP synthase subunit alpha KEEP 1464878..1464883 1464878 1464883 I NA NA IG1330_Rv1308-Rv1309 KEEP 1464884..1465801 1464884 1465801 + 305 15608449 atpG Rv1309 COG0224C I.B.8 essential F0F1 ATP synthase subunit gamma KEEP 1465802..1465840 1465802 1465840 I NA NA IG1331_Rv1309-Rv1310 KEEP 1465841..1467301 1465841 1467301 + 486 15608450 atpD Rv1310 COG0055C I.B.8 essential F0F1 ATP synthase subunit beta KEEP 1467302..1467314 1467302 1467314 I NA NA IG1332_Rv1310-Rv1311 KEEP 1467315..1467680 1467315 1467680 + 121 15608451 atpC Rv1311 COG0355C I.B.8 essential F0F1 ATP synthase subunit epsilon KEEP 1467681..1467687 1467681 1467687 I NA NA IG1333_Rv1311-Rv1312 KEEP 1467688..1468131 1467688 1468131 + 147 15608452 - Rv1312 - V nonessential hypothetical protein KEEP 1468132..1468170 1468132 1468159 I NA NA IG1334_Rv1312-Rv1313c Annotation + homoplasy analysis DISCARD 1468132..1468170 1468160 1468170 I NA NA IG1334_Rv1312-Rv1313c Annotation + Marin et al 2022 DISCARD 1468171..1469505 1468171 1469505 - 444 15608453 - Rv1313c COG3464L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1469506..1469670 1469506 1469623 I NA NA IG1335_Rv1313c-Rv1314c Annotation + Marin et al 2022 DISCARD 1469506..1469670 1469624 1469670 I NA NA IG1335_Rv1313c-Rv1314c Annotation + homoplasy analysis DISCARD 1469671..1470252 1469671 1470252 - 193 15608454 - Rv1314c COG2096S V nonessential hypothetical protein KEEP 1470253..1470320 1470253 1470320 I NA NA IG1336_Rv1314c-Rv1315 KEEP 1470321..1471577 1470321 1471577 + 418 15608455 murA Rv1315 COG0766M II.C.3 essential UDP-N-acetylglucosamine 1-carboxyvinyltransferase KEEP 1471578..1471845 1471578 1471845 I NA NA IG1337_Rv1315-rrs KEEP 1471846..1473382 1471846 1473382 I NA NA IG_rrs-16sRNA DR-ami-sm KEEP 1473383..1477133 1473383 1477133 I NA NA IG_rrs-Rv1316c KEEP 1477134..1477631 1477134 1477631 - 165 15608456 ogt Rv1316c COG0350L II.A.5 nonessential methylated-DNA--protein-cysteine methyltransferase KEEP 1477628..1479118 1477628 1479118 - 496 15608457 alkA Rv1317c COG0122L,COG2169F II.A.5 nonessential bifunctional methylated-DNA--protein-cysteine methyltransferase/O-6-methylguanine-DNA transcription regulator KEEP 1479119..1479198 1479119 1479198 I NA NA IG1339_Rv1317c-Rv1318c KEEP 1479199..1480824 1479199 1479347 - 541 15608458 - Rv1318c COG2114T IV.I nonessential adenylate cyclase KEEP 1479199..1480824 1479348 1479409 - 541 15608458 - Rv1318c COG2114T IV.I nonessential adenylate cyclase Only Marin et al 2022 KEEP 1479199..1480824 1479410 1479486 - 541 15608458 - Rv1318c COG2114T IV.I nonessential adenylate cyclase KEEP 1479199..1480824 1479487 1479538 - 541 15608458 - Rv1318c COG2114T IV.I nonessential adenylate cyclase Only Marin et al 2022 KEEP 1479199..1480824 1479539 1479715 - 541 15608458 - Rv1318c COG2114T IV.I nonessential adenylate cyclase KEEP 1479199..1480824 1479716 1479925 - 541 15608458 - Rv1318c COG2114T IV.I nonessential adenylate cyclase Only Marin et al 2022 KEEP 1479199..1480824 1479926 1480824 - 541 15608458 - Rv1318c COG2114T IV.I nonessential adenylate cyclase KEEP 1480825..1480893 1480825 1480893 I NA NA IG1340_Rv1318c-Rv1319c KEEP 1480894..1482501 1480894 1480943 - 535 15608459 - Rv1319c COG2114T IV.I nonessential adenylate cyclase KEEP 1480894..1482501 1480944 1480945 - 535 15608459 - Rv1319c COG2114T IV.I nonessential adenylate cyclase Marin et al 2022 + homoplasy analysis DISCARD 1480894..1482501 1480946 1480946 - 535 15608459 - Rv1319c COG2114T IV.I nonessential adenylate cyclase KEEP 1480894..1482501 1480947 1481670 - 535 15608459 - Rv1319c COG2114T IV.I nonessential adenylate cyclase Only Marin et al 2022 KEEP 1480894..1482501 1481671 1482501 - 535 15608459 - Rv1319c COG2114T IV.I nonessential adenylate cyclase KEEP 1482502..1482513 1482502 1482513 I NA NA IG1341_Rv1319c-Rv1320c KEEP 1482514..1484217 1482514 1482822 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase KEEP 1482514..1484217 1482823 1482878 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase Only Marin et al 2022 KEEP 1482514..1484217 1482879 1483108 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase KEEP 1482514..1484217 1483109 1483165 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase Only Marin et al 2022 KEEP 1482514..1484217 1483166 1483195 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase KEEP 1482514..1484217 1483196 1483254 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase Only Marin et al 2022 KEEP 1482514..1484217 1483255 1483263 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase KEEP 1482514..1484217 1483264 1483318 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase Only Marin et al 2022 KEEP 1482514..1484217 1483319 1484217 - 567 15608460 - Rv1320c COG2114T IV.I nonessential adenylate cyclase KEEP 1484218..1484278 1484218 1484278 I NA NA IG1342_Rv1320c-Rv1321 KEEP 1484279..1484959 1484279 1484959 + 226 15608461 - Rv1321 COG1637L V nonessential hypothetical protein KEEP 1484960..1484981 1484960 1484981 I NA NA IG1343_Rv1321-Rv1322 KEEP 1484982..1485278 1484982 1485278 + 98 15608462 - Rv1322 - V nonessential hypothetical protein KEEP 1485279..1485312 1485279 1485312 I NA NA IG1344_Rv1322-Rv1322A KEEP 1485313..1485771 1485313 1485771 - 152 57116847 - Rv1322A COG0346E V nonessential hypothetical protein KEEP 1485772..1485861 1485772 1485861 I NA NA IG1345_Rv1322A-Rv1323 KEEP 1485862..1487031 1485862 1487031 + 389 15608463 fadA4 Rv1323 COG0183I I.A.3 essential acetyl-CoA acetyltransferase KEEP 1487032..1487160 1487032 1487160 I NA NA IG1346_Rv1323-Rv1324 KEEP 1487161..1488075 1487161 1488075 + 304 15608464 - Rv1324 COG3118O VII nonessential thioredoxin KEEP 1488076..1488153 1488076 1488081 I NA NA IG1347_Rv1324-Rv1325c KEEP 1488076..1488153 1488082 1488147 I NA NA IG1347_Rv1324-Rv1325c Annotation + Marin et al 2022 DISCARD 1488076..1488153 1488148 1488153 I NA NA IG1347_Rv1324-Rv1325c KEEP 1488154..1489965 1488154 1488382 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488383 1488410 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488411 1488412 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488413 1488420 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488421 1488428 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + homoplasy analysis DISCARD 1488154..1489965 1488429 1488757 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488758 1488759 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488760 1488766 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488767 1488775 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488776 1488788 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488789 1488790 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488791 1488794 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488795 1488806 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488807 1488810 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488811 1488812 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488813 1488839 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488840 1488842 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488843 1488848 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1488849 1488895 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1488896 1489512 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1489513 1489536 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1489537 1489647 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1489648 1489737 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1488154..1489965 1489738 1489798 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1488154..1489965 1489799 1489965 - 603 57116848 PE_PGRS24 Rv1325c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1489966..1490116 1489966 1490116 I NA NA IG1348_Rv1325c-Rv1326c KEEP 1490117..1492312 1490117 1492312 - 731 15608466 glgB Rv1326c COG0296G II.A.8 essential glycogen branching enzyme KEEP 1492313..1492319 1492313 1492319 I NA NA IG1349_Rv1326c-Rv1327c KEEP 1492320..1494425 1492320 1494425 - 701 57116849 glgE Rv1327c COG0366G II.B.4 essential glucanase GLGE KEEP 1494426..1494563 1494426 1494563 I NA NA IG1350_Rv1327c-Rv1328 KEEP 1494564..1497155 1494564 1497155 + 863 15608468 glgP Rv1328 COG0058G II.A.8 nonessential glycogen phosphorylase GlgP KEEP 1497156..1497194 1497156 1497194 I NA NA IG1351_Rv1328-Rv1329c KEEP 1497195..1499189 1497195 1499189 - 664 15608469 dinG Rv1329c COG1199KL II.A.5 nonessential ATP-dependent helicase DING KEEP 1499190..1499212 1499190 1499212 I NA NA IG1352_Rv1329c-Rv1330c KEEP 1499213..1500559 1499213 1500559 - 448 57116850 - Rv1330c COG1488H V nonessential nicotinate phosphoribosyltransferase KEEP 1500560..1500660 1500560 1500660 I NA NA IG1353_Rv1330c-Rv1331 KEEP 1500661..1500966 1500661 1500966 + 101 15608471 clpS Rv1331 COG2127S V nonessential ATP-dependent Clp protease adaptor protein ClpS KEEP 1500926..1501582 1500926 1501582 + 218 15608472 - Rv1332 - I.J.1 essential transcriptional regulatory protein KEEP 1501583..1501598 1501583 1501598 I NA NA IG1355_Rv1332-Rv1333 KEEP 1501599..1502633 1501599 1502633 + 344 15608473 - Rv1333 COG3191EQ II.B.4 essential hydrolase KEEP 1502634..1502640 1502634 1502640 I NA NA IG1356_Rv1333-Rv1334 KEEP 1502641..1503081 1502641 1503081 + 146 15608474 - Rv1334 COG1310R V nonessential hypothetical protein KEEP 1503082..1503102 1503082 1503102 I NA NA IG1357_Rv1334-Rv1335 KEEP 1503103..1503384 1503103 1503384 + 93 15608475 - Rv1335 COG1977H VI nonessential 9.5 kDa culture filtrate antigen CFP10A KEEP 1503385..1503393 1503385 1503393 I NA NA IG1358_Rv1335-Rv1336 KEEP 1503394..1504365 1503394 1504365 + 323 15608476 cysM Rv1336 COG0031E I.D.3 nonessential cysteine synthase B CysM KEEP 1504356..1505078 1504356 1505078 + 240 15608477 - Rv1337 COG0705R II.C.5 nonessential integral membrane protein KEEP 1505075..1505890 1505075 1505890 + 271 15608478 murI Rv1338 COG0796M II.C.3 essential glutamate racemase KEEP 1505891..1505916 1505891 1505916 I NA NA IG1361_Rv1338-Rv1339 KEEP 1505917..1506738 1505917 1506738 + 273 15608479 - Rv1339 COG1234R V essential hypothetical protein KEEP 1506739..1506754 1506739 1506754 I NA NA IG1362_Rv1339-Rv1340 KEEP 1506755..1507534 1506755 1507534 + 259 15608480 rph Rv1340 COG0689J II.B.1 nonessential ribonuclease PH KEEP 1507535..1507572 1507535 1507572 I NA NA IG1363_Rv1340-Rv1341 KEEP 1507573..1508187 1507573 1508187 + 204 15608481 - Rv1341 COG0127F V nonessential putative deoxyribonucleotide triphosphate pyrophosphatase KEEP 1508184..1508546 1508184 1508546 - 120 57116851 - Rv1342c - I.I essential hypothetical protein KEEP 1508543..1508923 1508543 1508923 - 126 15608483 lprD Rv1343c COG4578K II.C.1 nonessential lipoprotein LprD KEEP 1508924..1508967 1508924 1508967 I NA NA IG1366_Rv1343c-Rv1344 KEEP 1508968..1509288 1508968 1509288 + 106 15608484 - Rv1344 COG0236IQ I.H.1 nonessential acyl carrier protein KEEP 1509281..1510846 1509281 1510846 + 521 15608485 fadD33 Rv1345 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1510846..1512006 1510846 1512006 + 386 15608486 fadE14 Rv1346 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase KEEP 1511973..1512605 1511973 1512605 - 210 15608487 - Rv1347c COG1670J IV.D essential hypothetical protein KEEP 1512606..1513046 1512606 1513046 I NA NA IG1370_Rv1347c-Rv1348 KEEP 1513047..1515626 1513047 1515626 + 859 15608488 - Rv1348 COG1132V,COG2375P II.C.5 essential drugs-transport transmembrane ATP-binding protein ABC transporter KEEP 1515623..1517362 1515623 1517362 + 579 15608489 - Rv1349 COG1132V II.C.5 essential drugs-transport transmembrane ATP-binding protein ABC transporter KEEP 1517363..1517490 1517363 1517490 I NA NA IG1372_Rv1349-Rv1350 KEEP 1517491..1518234 1517491 1518234 + 247 15608490 fabG Rv1350 COG1028IQR I.H.1 essential 3-ketoacyl-(acyl-carrier-protein) reductase KEEP 1518231..1518560 1518231 1518560 + 109 15608491 - Rv1351 - VI nonessential hypothetical protein KEEP 1518561..1518762 1518561 1518762 I NA NA IG1374_Rv1351-Rv1352 KEEP 1518763..1519134 1518763 1519134 + 123 15608492 - Rv1352 - V nonessential hypothetical protein KEEP 1519135..1519199 1519135 1519199 I NA NA IG1375_Rv1352-Rv1353c KEEP 1519200..1519985 1519200 1519985 - 261 15608493 - Rv1353c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 1519986..1520004 1519986 1520004 I NA NA IG1376_Rv1353c-Rv1354c KEEP 1520005..1521876 1520005 1521876 - 623 15608494 - Rv1354c COG2199T,COG2200T V nonessential hypothetical protein KEEP 1521877..1521884 1521877 1521884 I NA NA IG1377_Rv1354c-Rv1355c KEEP 1521885..1524032 1521885 1524032 - 715 15608495 moeY Rv1355c COG0476H I.G.4 nonessential hypothetical protein KEEP 1524029..1524820 1524029 1524570 - 263 15608496 - Rv1356c - VI nonessential hypothetical protein KEEP 1524029..1524820 1524571 1524574 - 263 15608496 - Rv1356c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 1524029..1524820 1524575 1524820 - 263 15608496 - Rv1356c - VI nonessential hypothetical protein KEEP 1524821..1525292 1524821 1525292 I NA NA IG1379_Rv1356c-Rv1357c KEEP 1525293..1526216 1525293 1526216 - 307 15608497 - Rv1357c COG2200T V nonessential hypothetical protein KEEP 1526217..1526611 1526217 1526611 I NA NA IG1380_Rv1357c-Rv1358 KEEP 1526612..1530091 1526612 1530091 + 1159 15608498 - Rv1358 COG2114T,COG2771K,COG3903R I.J.1 nonessential transcriptional regulatory protein KEEP 1530092..1530172 1530092 1530172 I NA NA IG1381_Rv1358-Rv1359 KEEP 1530173..1530925 1530173 1530925 + 250 15608499 - Rv1359 COG2114T I.J.1 nonessential transcriptional regulatory protein KEEP 1530926..1531347 1530926 1531347 I NA NA IG1382_Rv1359-Rv1360 KEEP 1531348..1532370 1531348 1532370 + 340 15608500 - Rv1360 COG2141C I.B.7 nonessential oxidoreductase KEEP 1532371..1532442 1532371 1532442 I NA NA IG1383_Rv1360-Rv1361c KEEP 1532443..1533633 1532443 1532534 - 396 57116852 PPE19 Rv1361c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1532443..1533633 1532535 1532922 - 396 57116852 PPE19 Rv1361c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1532443..1533633 1532923 1532985 - 396 57116852 PPE19 Rv1361c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + homoplasy analysis DISCARD 1532443..1533633 1532986 1533633 - 396 57116852 PPE19 Rv1361c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1533634..1533947 1533634 1533658 I NA NA IG1384_Rv1361c-Rv1362c Annotation + Marin et al 2022 DISCARD 1533634..1533947 1533659 1533947 I NA NA IG1384_Rv1361c-Rv1362c KEEP 1533948..1534610 1533948 1534610 - 220 15608502 - Rv1362c - II.C.5 nonessential hypothetical protein KEEP 1534607..1535392 1534607 1535392 - 261 15608503 - Rv1363c - II.C.5 nonessential hypothetical protein KEEP 1535393..1535682 1535393 1535682 I NA NA IG1386_Rv1363c-Rv1364c KEEP 1535683..1537644 1535683 1537644 - 653 57116853 - Rv1364c COG2172T,COG2202T,COG2208TK II.A.7 nonessential hypothetical protein KEEP 1537645..1537782 1537645 1537782 I NA NA IG1387_Rv1364c-Rv1365c KEEP 1537783..1538169 1537783 1538169 - 128 15608505 rsfA Rv1365c COG1366T II.A.7 nonessential anti-anti-sigma factor RSFA (anti-sigma factor antagonist) (regulator of sigma F A) KEEP 1538170..1538389 1538170 1538389 I NA NA IG1388_Rv1365c-Rv1366 KEEP 1538390..1539211 1538390 1539211 + 273 15608506 - Rv1366 COG2357S VI nonessential hypothetical protein KEEP 1539212..1539511 1539212 1539511 I NA NA IG1389_Rv1366-Rv1367c KEEP 1539512..1540645 1539512 1540645 - 377 15608507 - Rv1367c COG1680V II.C.3 nonessential hypothetical protein KEEP 1540646..1541019 1540646 1541019 I NA NA IG1390_Rv1367c-Rv1368 KEEP 1541020..1541805 1541020 1541805 + 261 15608508 lprF Rv1368 - II.C.1 nonessential lipoprotein LprF KEEP 1541806..1541993 1541806 1541943 I NA NA IG1391_Rv1368-Rv1369c KEEP 1541806..1541993 1541944 1541993 I NA NA IG1391_Rv1368-Rv1369c Annotation + Marin et al 2022 DISCARD 1541994..1542878 1541994 1542878 - 294 15608509 - Rv1369c COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1542879..1542928 1542879 1542928 I NA NA IG1392_Rv1369c-Rv1370c repeat Annotation + Marin et al 2022 DISCARD 1542929..1543255 1542929 1543255 - 108 15608510 - Rv1370c COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 1543256..1543358 1543256 1543358 I NA NA IG1393_Rv1370c-Rv1371 Annotation + Marin et al 2022 DISCARD 1543359..1544828 1543359 1543431 + 489 15608511 - Rv1371 - II.C.4 essential hypothetical protein Only Marin et al 2022 KEEP 1543359..1544828 1543432 1543452 + 489 15608511 - Rv1371 - II.C.4 essential hypothetical protein KEEP 1543359..1544828 1543453 1543457 + 489 15608511 - Rv1371 - II.C.4 essential hypothetical protein Only Marin et al 2022 KEEP 1543359..1544828 1543458 1543461 + 489 15608511 - Rv1371 - II.C.4 essential hypothetical protein KEEP 1543359..1544828 1543462 1543480 + 489 15608511 - Rv1371 - II.C.4 essential hypothetical protein Only Marin et al 2022 KEEP 1543359..1544828 1543481 1544828 + 489 15608511 - Rv1371 - II.C.4 essential hypothetical protein KEEP 1544825..1546006 1544825 1546006 + 393 57116854 - Rv1372 COG3424Q I.I nonessential hypothetical protein KEEP 1546007..1546011 1546007 1546011 I NA NA IG1395_Rv1372-Rv1373 KEEP 1546012..1546992 1546012 1546992 + 326 15608513 - Rv1373 - IV.H nonessential glycolipid sulfotransferase KEEP 1546993..1547071 1546993 1547071 I NA NA IG1396_Rv1373-Rv1374c KEEP 1547072..1547530 1547072 1547530 - 152 57116855 - Rv1374c - VI nonessential hypothetical protein KEEP 1547531..1547831 1547531 1547831 I NA NA IG1397_Rv1374c-Rv1375 KEEP 1547832..1549151 1547832 1549151 + 439 15608515 - Rv1375 COG1944S V nonessential hypothetical protein KEEP 1549148..1550641 1549148 1550641 + 497 15608516 - Rv1376 COG3482S V nonessential hypothetical protein KEEP 1550579..1551217 1550579 1551217 - 212 15608517 - Rv1377c COG0500QR IV.H nonessential putative transferase KEEP 1551218..1551227 1551218 1551227 I NA NA IG1400_Rv1377c-Rv1378c KEEP 1551228..1552655 1551228 1552655 - 475 15608518 - Rv1378c COG1403V V nonessential hypothetical protein KEEP 1552654..1553235 1552654 1553235 + 193 15608519 pyrR Rv1379 COG2065F I.J.1 nonessential pyrimidine regulatory protein PyrR KEEP 1553232..1554191 1553232 1554191 + 319 15608520 pyrB Rv1380 COG0540F I.F.2 essential aspartate carbamoyltransferase catalytic subunit KEEP 1554188..1555480 1554188 1555480 + 430 15608521 pyrC Rv1381 COG0044F I.F.2 essential dihydroorotase KEEP 1555477..1555974 1555477 1555974 + 165 15608522 - Rv1382 - II.C.5 essential export or membrane protein KEEP 1555971..1557101 1555971 1557101 + 376 15608523 carA Rv1383 COG0505EF I.F.2 essential carbamoyl phosphate synthase small subunit KEEP 1557101..1560448 1557101 1560448 + 1115 57116856 carB Rv1384 COG0458EF I.F.2 nonessential carbamoyl phosphate synthase large subunit KEEP 1560445..1561269 1560445 1561269 + 274 15608524 pyrF Rv1385 COG0284F I.F.2 nonessential orotidine 5'-phosphate decarboxylase KEEP 1561270..1561463 1561270 1561463 I NA NA IG1408_Rv1385-Rv1386 KEEP 1561464..1561772 1561464 1561772 + 102 57116857 PE15 Rv1386 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1561769..1563388 1561769 1563388 + 539 57116858 PPE20 Rv1387 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1563389..1563693 1563389 1563693 I NA NA IG1410_Rv1387-Rv1388 KEEP 1563694..1564266 1563694 1564266 + 190 15608527 mihF Rv1388 - II.A.4 essential putative integration host factor MIHF KEEP 1564267..1564400 1564267 1564400 I NA NA IG1411_Rv1388-Rv1389 KEEP 1564401..1565027 1564401 1565027 + 208 15608528 gmk Rv1389 COG0194F I.F.1 essential guanylate kinase KEEP 1565028..1565092 1565028 1565092 I NA NA IG1412_Rv1389-Rv1390 KEEP 1565093..1565425 1565093 1565425 + 110 15608529 rpoZ Rv1390 COG1758K VII essential DNA-directed RNA polymerase subunit omega KEEP 1565426..1565440 1565426 1565440 I NA NA IG1413_Rv1390-Rv1391 KEEP 1565441..1566697 1565441 1566697 + 418 15608530 dfp Rv1391 COG0452H VII essential bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase KEEP 1566698..1566824 1566698 1566824 I NA NA IG1414_Rv1391-Rv1392 KEEP 1566825..1568036 1566825 1568036 + 403 15608531 metK Rv1392 COG0192H I.D.2 essential S-adenosylmethionine synthetase KEEP 1568037..1568108 1568037 1568047 I NA NA IG1415_Rv1392-Rv1393c KEEP 1568037..1568108 1568048 1568106 I NA NA IG1415_Rv1392-Rv1393c Only Marin et al 2022 KEEP 1568037..1568108 1568107 1568108 I NA NA IG1415_Rv1392-Rv1393c KEEP 1568109..1569587 1568109 1569587 - 492 15608532 - Rv1393c COG2072P VI nonessential monoxygenase KEEP 1569584..1570969 1569584 1570969 - 461 57116859 cyp132 Rv1394c COG2124Q IV.F nonessential cytochrome P450 132 KEEP 1570970..1571046 1570970 1571046 I NA NA IG1417_Rv1394c-Rv1395 KEEP 1571047..1572081 1571047 1572081 + 344 57116860 - Rv1395 COG2207K I.J.1 nonessential transcriptional regulatory protein KEEP 1572082..1572126 1572082 1572126 I NA NA IG1418_Rv1395-Rv1396c KEEP 1572127..1573857 1572127 1572183 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1572127..1573857 1572184 1572482 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1572127..1573857 1572483 1572498 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1572127..1573857 1572499 1572621 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1572127..1573857 1572622 1572743 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1572127..1573857 1572744 1573530 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1572127..1573857 1573531 1573554 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1572127..1573857 1573555 1573606 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1572127..1573857 1573607 1573857 - 576 57116861 PE_PGRS25 Rv1396c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1573858..1574111 1573858 1574111 I NA NA IG1419_Rv1396c-Rv1397c KEEP 1574112..1574513 1574112 1574513 - 133 15608535 - Rv1397c COG1487R V nonessential hypothetical protein KEEP 1574510..1574767 1574510 1574767 - 85 15608536 - Rv1398c - V nonessential hypothetical protein KEEP 1574768..1574849 1574768 1574849 I NA NA IG1421_Rv1398c-Rv1399c KEEP 1574850..1575809 1574850 1575809 - 319 15608537 lipH Rv1399c COG0657I II.B.5 nonessential lipase LipH KEEP 1575810..1575833 1575810 1575833 I NA NA IG1422_Rv1399c-Rv1400c KEEP 1575834..1576796 1575834 1576796 - 320 15608538 lipI Rv1400c COG0657I II.B.5 nonessential lipase LipH KEEP 1576797..1576929 1576797 1576929 I NA NA IG1423_Rv1400c-Rv1401 KEEP 1576930..1577532 1576930 1577532 + 200 15608539 - Rv1401 COG3714S II.C.5 nonessential hypothetical protein KEEP 1577533..1577612 1577533 1577612 I NA NA IG1424_Rv1401-Rv1402 KEEP 1577613..1579580 1577613 1579580 + 655 15608540 priA Rv1402 COG1198L II.A.5 nonessential primosome assembly protein PriA KEEP 1579581..1579597 1579581 1579597 I NA NA IG1425_Rv1402-Rv1403c KEEP 1579598..1580422 1579598 1580422 - 274 15608541 - Rv1403c COG0500QR IV.H nonessential putative methyltransferase KEEP 1580423..1580590 1580423 1580590 I NA NA IG1426_Rv1403c-Rv1404 KEEP 1580591..1581073 1580591 1581073 + 160 15608542 - Rv1404 COG1846K I.J.1 nonessential transcriptional regulatory protein KEEP 1581074..1581144 1581074 1581144 I NA NA IG1427_Rv1404-Rv1405c KEEP 1581145..1581969 1581145 1581969 - 274 15608543 - Rv1405c COG0500QR IV.H essential putative methyltransferase KEEP 1581970..1582165 1581970 1582165 I NA NA IG1428_Rv1405c-Rv1406 KEEP 1582166..1583104 1582166 1583104 + 312 15608544 fmt Rv1406 COG0223J II.A.3 essential methionyl-tRNA formyltransferase KEEP 1583101..1584474 1583101 1584474 + 457 15608545 fmu Rv1407 COG0144J II.A.4 nonessential Fmu protein (SUN protein) KEEP 1584475..1584498 1584475 1584498 I NA NA IG1430_Rv1407-Rv1408 KEEP 1584499..1585197 1584499 1585197 + 232 15608546 rpe Rv1408 COG0036G I.B.5 nonessential ribulose-phosphate 3-epimerase KEEP 1585194..1586213 1585194 1586213 + 339 15608547 ribG Rv1409 COG0117H,COG1985H I.G.9 essential bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase KEEP 1586210..1587766 1586210 1587766 - 518 15608548 - Rv1410c COG0477GEPR III.A.6 essential aminoglycosides/tetracycline-transport integral membrane protein KEEP 1587767..1587771 1587767 1587771 I NA NA IG1433_Rv1410c-Rv1411c KEEP 1587772..1588482 1587772 1588482 - 236 15608549 lprG Rv1411c - II.C.1 essential lipoprotein LprG KEEP 1588483..1588566 1588483 1588566 I NA NA IG1434_Rv1411c-Rv1412 KEEP 1588567..1589172 1588567 1589172 + 201 15608550 ribC Rv1412 COG0307H I.G.9 nonessential riboflavin synthase subunit alpha KEEP 1589173..1589385 1589173 1589385 I NA NA IG1435_Rv1412-Rv1413 KEEP 1589386..1589901 1589386 1589901 + 171 15608551 - Rv1413 COG3616E V nonessential hypothetical protein KEEP 1589891..1590292 1589891 1590292 + 133 15608552 - Rv1414 COG3616E V nonessential hypothetical protein KEEP 1590293..1590396 1590293 1590396 I NA NA IG1437_Rv1414-Rv1415 KEEP 1590397..1591674 1590397 1591674 + 425 15608553 ribA2 Rv1415 COG0108H,COG0807H I.G.9 essential bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein KEEP 1591675..1591688 1591675 1591688 I NA NA IG1438_Rv1415-Rv1416 KEEP 1591689..1592153 1591689 1592153 + 154 15608554 ribH Rv1416 COG0054H I.G.9 essential riboflavin synthase subunit beta KEEP 1592150..1592614 1592150 1592614 + 154 15608555 - Rv1417 - II.C.5 nonessential hypothetical protein KEEP 1592615..1592638 1592615 1592638 I NA NA IG1440_Rv1417-Rv1418 KEEP 1592639..1593325 1592639 1593325 + 228 15608556 lprH Rv1418 - II.C.1 nonessential lipoprotein LprH KEEP 1593326..1593504 1593326 1593504 I NA NA IG1441_Rv1418-Rv1419 KEEP 1593505..1593978 1593505 1593978 + 157 15608557 - Rv1419 - VI nonessential hypothetical protein KEEP 1593979..1594041 1593979 1594041 I NA NA IG1442_Rv1419-Rv1420 KEEP 1594042..1595982 1594042 1595982 + 646 15608558 uvrC Rv1420 COG0322L II.A.5 essential excinuclease ABC subunit C KEEP 1595979..1596884 1595979 1596884 + 301 15608559 - Rv1421 COG1660R V nonessential hypothetical protein KEEP 1596881..1597909 1596881 1597909 + 342 15608560 - Rv1422 COG0391S V essential hypothetical protein KEEP 1597906..1598883 1597906 1598883 + 325 15608561 whiA Rv1423 COG1481S I.J.1 nonessential transcriptional regulatory protein WHIA KEEP 1598884..1598892 1598884 1598892 I NA NA IG1446_Rv1423-Rv1424c KEEP 1598893..1599654 1598893 1599654 - 253 15608562 - Rv1424c - II.C.5 nonessential hypothetical protein KEEP 1599655..1599657 1599655 1599657 I NA NA IG1447_Rv1424c-Rv1425 KEEP 1599658..1601037 1599658 1601037 + 459 15608563 - Rv1425 - V nonessential hypothetical protein KEEP 1601038..1601058 1601038 1601058 I NA NA IG1448_Rv1425-Rv1426c KEEP 1601059..1602321 1601059 1602321 - 420 15608564 lipO Rv1426c COG0657I II.B.5 nonessential esterase LipO KEEP 1602321..1603928 1602321 1603928 - 535 15608565 fadD12 Rv1427c COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1603929..1603931 1603929 1603931 I NA NA IG1450_Rv1427c-Rv1428c KEEP 1603932..1604759 1603932 1604759 - 275 15608566 - Rv1428c COG0204I V nonessential hypothetical protein KEEP 1604760..1604877 1604760 1604877 I NA NA IG1451_Rv1428c-Rv1429 KEEP 1604878..1606146 1604878 1606146 + 422 15608567 - Rv1429 COG2508TQ V nonessential hypothetical protein KEEP 1606147..1606385 1606147 1606385 I NA NA IG1452_Rv1429-Rv1430 KEEP 1606386..1607972 1606386 1606513 + 528 57116862 PE16 Rv1430 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1606386..1607972 1606514 1606565 + 528 57116862 PE16 Rv1430 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 1606386..1607972 1606566 1607972 + 528 57116862 PE16 Rv1430 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1607973..1608082 1607973 1608082 I NA NA IG1453_Rv1430-Rv1431 KEEP 1608083..1609852 1608083 1609852 + 589 15608569 - Rv1431 - II.C.5 nonessential hypothetical protein KEEP 1609849..1611270 1609849 1611270 + 473 15608570 - Rv1432 COG1233Q VI nonessential dehydrogenase KEEP 1611271..1611433 1611271 1611433 I NA NA IG1455_Rv1432-Rv1433 KEEP 1611434..1612249 1611434 1612249 + 271 15608571 - Rv1433 COG1376S VI nonessential hypothetical protein KEEP 1612250..1612255 1612250 1612255 I NA NA IG1456_Rv1433-Rv1434 KEEP 1612256..1612393 1612256 1612393 + 45 15608572 - Rv1434 - VI nonessential hypothetical protein KEEP 1612342..1612950 1612342 1612561 - 202 15608573 - Rv1435c - VI nonessential proline, glycine, valine-rich secreted protein KEEP 1612342..1612950 1612562 1612665 - 202 15608573 - Rv1435c - VI nonessential proline, glycine, valine-rich secreted protein Marin et al 2022 + homoplasy analysis DISCARD 1612342..1612950 1612666 1612950 - 202 15608573 - Rv1435c - VI nonessential proline, glycine, valine-rich secreted protein KEEP 1612951..1613306 1612951 1613306 I NA NA IG1458_Rv1435c-Rv1436 KEEP 1613307..1614326 1613307 1614326 + 339 15608574 gap Rv1436 COG0057G I.B.1 essential glyceraldehyde-3-phosphate dehydrogenase KEEP 1614327..1614328 1614327 1614328 I NA NA IG1459_Rv1436-Rv1437 KEEP 1614329..1615567 1614329 1615567 + 412 15608575 pgk Rv1437 COG0126G I.B.1 essential phosphoglycerate kinase KEEP 1615564..1616349 1615564 1616349 + 261 15608576 tpiA Rv1438 COG0149G I.B.1 essential triosephosphate isomerase KEEP 1616350..1616960 1616350 1616960 I NA NA IG1461_Rv1438-Rv1439c KEEP 1616961..1617386 1616961 1617386 - 141 15608577 - Rv1439c - VI nonessential hypothetical protein KEEP 1617387..1617836 1617387 1617836 I NA NA IG1462_Rv1439c-Rv1440 KEEP 1617837..1618070 1617837 1618070 + 77 57116863 secG Rv1440 COG1314U III.D nonessential preprotein translocase subunit SecG KEEP 1618071..1618208 1618071 1618208 I NA NA IG1463_Rv1440-Rv1441c KEEP 1618209..1619684 1618209 1619684 - 491 57116864 PE_PGRS26 Rv1441c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1619685..1619790 1619685 1619790 I NA NA IG1464_Rv1441c-Rv1442 KEEP 1619791..1622091 1619791 1622091 + 766 15608580 bisC Rv1442 COG0243C I.G.1 nonessential biotin sulfoxide reductase KEEP 1622092..1622206 1622092 1622206 I NA NA IG1465_Rv1442-Rv1443c KEEP 1622207..1622692 1622207 1622692 - 161 15608581 - Rv1443c COG4276S VI nonessential hypothetical protein KEEP 1622693..1623286 1622693 1623286 I NA NA IG1466_Rv1443c-Rv1444c KEEP 1623287..1623697 1623287 1623697 - 136 15608582 - Rv1444c COG0419L VI nonessential hypothetical protein KEEP 1623698..1623713 1623698 1623713 I NA NA IG1467_Rv1444c-Rv1445c KEEP 1623714..1624457 1623714 1624457 - 247 15608583 devB Rv1445c COG0363G I.B.5 nonessential 6-phosphogluconolactonase KEEP 1624454..1625365 1624454 1625353 - 303 15608584 opcA Rv1446c COG3429G I.B.5 essential putative OXPP cycle protein OPCA KEEP 1624454..1625365 1625354 1625365 - 303 15608584 opcA Rv1446c COG3429G I.B.5 essential putative OXPP cycle protein OPCA Only Marin et al 2022 KEEP 1625366..1625417 1625366 1625417 I NA NA IG1469_Rv1446c-Rv1447c Only Marin et al 2022 KEEP 1625418..1626962 1625418 1625422 - 514 15608585 zwf2 Rv1447c COG0364G I.B.5 nonessential glucose-6-phosphate 1-dehydrogenase Only Marin et al 2022 KEEP 1625418..1626962 1625423 1626962 - 514 15608585 zwf2 Rv1447c COG0364G I.B.5 nonessential glucose-6-phosphate 1-dehydrogenase KEEP 1626959..1628080 1626959 1628080 - 373 15608586 tal Rv1448c COG0176G I.B.5 essential transaldolase KEEP 1628081..1628096 1628081 1628096 I NA NA IG1471_Rv1448c-Rv1449c KEEP 1628097..1630199 1628097 1630199 - 700 15608587 tkt Rv1449c COG0021G I.B.5 essential transketolase KEEP 1630200..1630637 1630200 1630637 I NA NA IG1472_Rv1449c-Rv1450c KEEP 1630638..1634627 1630638 1630813 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1630814 1630825 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1630826 1630826 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1630827 1630837 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1630838 1630838 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1630839 1630872 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1630873 1630873 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1630874 1630875 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1630876 1630995 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1630996 1631117 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1631118 1631390 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1631391 1631908 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1631909 1631935 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1631936 1631955 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1631956 1632056 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1632057 1632128 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1632129 1632217 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1632218 1632220 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1632221 1632230 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1632231 1632289 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1632290 1632354 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1632355 1632824 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1632825 1632855 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1632856 1632858 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1630638..1634627 1632859 1633190 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1630638..1634627 1633191 1634627 - 1329 57116865 PE_PGRS27 Rv1450c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1634628..1635028 1634628 1634797 I NA NA IG1473_Rv1450c-Rv1451 Annotation + Marin et al 2022 DISCARD 1634628..1635028 1634798 1635028 I NA NA IG1473_Rv1450c-Rv1451 KEEP 1635029..1635955 1635029 1635955 + 308 15608589 ctaB Rv1451 COG0109O I.B.6a nonessential protoheme IX farnesyltransferase KEEP 1635956..1636003 1635956 1636003 I NA NA IG1474_Rv1451-Rv1452c KEEP 1636004..1638229 1636004 1638229 - 741 57116866 PE_PGRS28 Rv1452c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1638230..1638380 1638230 1638380 I NA NA IG1475_Rv1452c-Rv1453 Annotation + Marin et al 2022 DISCARD 1638381..1639646 1638381 1638399 + 421 57116867 - Rv1453 COG2508TQ VII nonessential transcriptional activator protein Only Marin et al 2022 KEEP 1638381..1639646 1638400 1639646 + 421 57116867 - Rv1453 COG2508TQ VII nonessential transcriptional activator protein KEEP 1639647..1639673 1639647 1639673 I NA NA IG1476_Rv1453-Rv1454c KEEP 1639674..1640660 1639674 1640660 - 328 15608592 qor Rv1454c COG0604CR I.B.7 nonessential quinone reductase KEEP 1640661..1640679 1640661 1640679 I NA NA IG1477_Rv1454c-Rv1455 KEEP 1640680..1641543 1640680 1641543 + 287 15608593 - Rv1455 - V nonessential hypothetical protein KEEP 1641493..1642425 1641493 1642425 - 310 15608594 - Rv1456c COG1612O II.C.5 essential unidentified antibiotic-transport integral membrane ABC transporter KEEP 1642426..1642536 1642426 1642536 I NA NA IG1479_Rv1456c-Rv1457c KEEP 1642537..1643322 1642537 1643322 - 261 15608595 - Rv1457c COG0842V II.C.5 essential unidentified antibiotic-transport integral membrane ABC transporter KEEP 1643319..1644260 1643319 1644241 - 313 15608596 - Rv1458c COG1131V III.A nonessential unidentified antibiotic-transport ATP-binding protein ABC transporter KEEP 1643319..1644260 1644242 1644260 - 313 15608596 - Rv1458c COG1131V III.A nonessential unidentified antibiotic-transport ATP-binding protein ABC transporter Only Marin et al 2022 KEEP 1644261..1644362 1644261 1644362 I NA NA IG1481_Rv1458c-Rv1459c Marin et al 2022 + homoplasy analysis DISCARD 1644363..1646138 1644363 1644372 - 591 15608597 - Rv1459c - II.C.5 essential integral membrane protein Only Marin et al 2022 KEEP 1644363..1646138 1644373 1646138 - 591 15608597 - Rv1459c - II.C.5 essential integral membrane protein KEEP 1646139..1646185 1646139 1646185 I NA NA IG1482_Rv1459c-Rv1460 KEEP 1646186..1646992 1646186 1646992 + 268 57116868 - Rv1460 COG2345K I.J.1 essential transcriptional regulatory protein KEEP 1646989..1649529 1646989 1649529 + 846 15608599 - Rv1461 COG0719O,COG1372L V essential hypothetical protein KEEP 1649526..1650719 1649526 1650719 + 397 15608600 - Rv1462 COG0719O V essential hypothetical protein KEEP 1650716..1651516 1650716 1651516 + 266 15608601 - Rv1463 COG0396O III.A essential ABC transporter ATP-binding protein KEEP 1651518..1652771 1651518 1652771 + 417 15608602 csd Rv1464 COG0520E VII essential cysteine desulfurase KEEP 1652768..1653256 1652768 1653256 + 162 15608603 - Rv1465 COG0822C VI essential nitrogen fixation related protein KEEP 1653231..1653578 1653231 1653578 + 115 15608604 - Rv1466 COG2151R V essential hypothetical protein KEEP 1653579..1653672 1653579 1653672 I NA NA IG1489_Rv1466-Rv1467c KEEP 1653673..1655502 1653673 1654153 - 609 15608605 fadE15 Rv1467c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE15 KEEP 1653673..1655502 1654154 1654206 - 609 15608605 fadE15 Rv1467c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE15 Only Marin et al 2022 KEEP 1653673..1655502 1654207 1655502 - 609 15608605 fadE15 Rv1467c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE15 KEEP 1655503..1655608 1655503 1655608 I NA NA IG1490_Rv1467c-Rv1468c KEEP 1655609..1656721 1655609 1655669 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1655609..1656721 1655670 1655721 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1655609..1656721 1655722 1655813 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1655609..1656721 1655814 1655815 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1655609..1656721 1655816 1656095 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1655609..1656721 1656096 1656208 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1655609..1656721 1656209 1656327 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1655609..1656721 1656328 1656410 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1655609..1656721 1656411 1656515 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1655609..1656721 1656516 1656596 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1655609..1656721 1656597 1656721 - 370 57116869 PE_PGRS29 Rv1468c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1656722..1656962 1656722 1656962 I NA NA IG1491_Rv1468c-Rv1469 KEEP 1656963..1658936 1656963 1658936 + 657 15608607 ctpD Rv1469 COG2217P III.A.2 essential cation transporter P-type ATPase D KEEP 1658937..1658979 1658937 1658979 I NA NA IG1492_Rv1469-Rv1470 KEEP 1658980..1659354 1658980 1659354 + 124 15608608 trxA Rv1470 COG0526OC I.G.10 nonessential thioredoxin TRXA KEEP 1659355..1659369 1659355 1659369 I NA NA IG1493_Rv1470-Rv1471 KEEP 1659370..1659741 1659370 1659741 + 123 57116870 trxB1 Rv1471 COG0526OC I.G.10 nonessential thioredoxin TRXB1 KEEP 1659742..1659762 1659742 1659762 I NA NA IG1494_Rv1471-Rv1472 KEEP 1659763..1660620 1659763 1660620 + 285 15608610 echA12 Rv1472 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 1660621..1660655 1660621 1660655 I NA NA IG1495_Rv1472-Rv1473 KEEP 1660656..1662284 1660656 1662284 + 542 15608611 - Rv1473 COG0488R III.A nonessential macrolide ABC transporter ATP-binding protein KEEP 1662285..1662380 1662285 1662380 I NA NA IG1496_Rv1473-Rv1473A KEEP 1662381..1662572 1662381 1662572 + 63 57116871 - Rv1473A - I.J.1 nonessential transcriptional regulatory protein KEEP 1662573..1662640 1662573 1662640 I NA NA IG1497_Rv1473A-Rv1474c KEEP 1662641..1663204 1662641 1663204 - 187 15608612 - Rv1474c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 1663205..1663214 1663205 1663214 I NA NA IG1498_Rv1474c-Rv1475c KEEP 1663215..1666046 1663215 1666046 - 943 15608613 acn Rv1475c COG1048C I.B.3 essential aconitate hydratase KEEP 1666047..1666203 1666047 1666203 I NA NA IG1499_Rv1475c-Rv1476 KEEP 1666204..1666764 1666204 1666764 + 186 15608614 - Rv1476 - II.C.5 essential hypothetical protein KEEP 1666765..1666989 1666765 1666989 I NA NA IG1500_Rv1476-Rv1477 KEEP 1666990..1668408 1666990 1668408 + 472 15608615 - Rv1477 COG0791M IV.A essential invasion protein KEEP 1668409..1668418 1668409 1668418 I NA NA IG1501_Rv1477-Rv1478 KEEP 1668419..1669144 1668419 1669144 + 241 15608616 - Rv1478 COG0791M IV.A nonessential invasion protein KEEP 1669145..1669282 1669145 1669282 I NA NA IG1502_Rv1478-Rv1479 KEEP 1669283..1670416 1669283 1670416 + 377 57116872 moxR1 Rv1479 COG0714R I.J.1 essential transcriptional regulatory protein MOXR1 KEEP 1670413..1671366 1670413 1671366 + 317 15608618 - Rv1480 COG1721R V essential hypothetical protein KEEP 1671367..1671376 1671367 1671376 I NA NA IG1504_Rv1480-Rv1481 KEEP 1671377..1672384 1671377 1672384 + 335 15608619 - Rv1481 COG2304R II.C.5 nonessential hypothetical protein KEEP 1672385..1672456 1672385 1672404 I NA NA IG1505_Rv1481-Rv1482c KEEP 1672385..1672456 1672405 1672456 I NA NA IG1505_Rv1481-Rv1482c Only Marin et al 2022 KEEP 1672457..1673299 1672457 1672466 - 280 57116873 - Rv1482c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 1672457..1673299 1672467 1673299 - 280 57116873 - Rv1482c - V nonessential hypothetical protein KEEP 1673300..1673439 1673300 1673439 I NA NA IG1506_Rv1482c-Rv1483 DR-eth-inh KEEP 1673440..1674183 1673440 1674183 + 247 15608621 fabG1 Rv1483 COG1028IQR I.H.1 DR-eth-inh nonessential 3-oxoacyl-[acyl-carrier protein] reductase FabG1 KEEP 1674184..1674201 1674184 1674201 I NA NA IG1507_Rv1483-Rv1484 KEEP 1674202..1675011 1674202 1675011 + 269 15608622 inhA Rv1484 COG0623I I.H.1 DR-eth-inh nonessential enoyl-(acyl carrier protein) reductase KEEP 1675012..1675016 1675012 1675016 I NA NA IG1508_Rv1484-Rv1485 KEEP 1675017..1676051 1675017 1676051 + 344 15608623 hemH Rv1485 COG0276H I.G.12 essential ferrochelatase KEEP 1676017..1676883 1676017 1676883 - 288 57116874 - Rv1486c - V nonessential hypothetical protein KEEP 1676884..1676940 1676884 1676940 I NA NA IG1510_Rv1486c-Rv1487 KEEP 1676941..1677375 1676941 1677375 + 144 15608625 - Rv1487 COG1585OU II.C.5 nonessential hypothetical protein KEEP 1677376..1677396 1677376 1677396 I NA NA IG1511_Rv1487-Rv1488 KEEP 1677397..1678542 1677397 1678542 + 381 15608626 - Rv1488 COG0330O VI nonessential hypothetical protein KEEP 1678543..1678551 1678543 1678551 I NA NA IG1512_Rv1488-Rv1489 KEEP 1678552..1678908 1678552 1678908 + 118 57116875 - Rv1489 - V nonessential hypothetical protein KEEP 1678909..1678941 1678909 1678941 I NA NA IG1513_Rv1489-Rv1489A KEEP 1678942..1679172 1678942 1678949 + 76 57116876 - Rv1489A COG1884I V nonessential hypothetical protein KEEP 1678942..1679172 1678950 1679019 + 76 57116876 - Rv1489A COG1884I V nonessential hypothetical protein Only Marin et al 2022 KEEP 1678942..1679172 1679020 1679172 + 76 57116876 - Rv1489A COG1884I V nonessential hypothetical protein KEEP 1679173..1679321 1679173 1679321 I NA NA IG1514_Rv1489A-Rv1490 KEEP 1679322..1680629 1679322 1680629 + 435 15608628 - Rv1490 - II.C.5 essential hypothetical protein KEEP 1680630..1681207 1680630 1681207 I NA NA IG1515_Rv1490-Rv1491c KEEP 1681208..1681966 1681208 1681966 - 252 15608629 - Rv1491c COG0398S II.C.5 nonessential hypothetical protein KEEP 1681967..1682156 1681967 1682156 I NA NA IG1516_Rv1491c-Rv1492 KEEP 1682157..1684004 1682157 1684004 + 615 15608630 mutA Rv1492 COG1884I,COG2185I I.A.3 nonessential methylmalonyl-CoA mutase small subunit KEEP 1684005..1686257 1684005 1685476 + 750 15608631 mutB Rv1493 COG1884I,COG2185I I.A.3 nonessential methylmalonyl-CoA mutase KEEP 1684005..1686257 1685477 1685546 + 750 15608631 mutB Rv1493 COG1884I,COG2185I I.A.3 nonessential methylmalonyl-CoA mutase Only Marin et al 2022 KEEP 1684005..1686257 1685547 1686257 + 750 15608631 mutB Rv1493 COG1884I,COG2185I I.A.3 nonessential methylmalonyl-CoA mutase KEEP 1686258..1686270 1686258 1686270 I NA NA IG1518_Rv1493-Rv1494 KEEP 1686271..1686573 1686271 1686573 + 100 15608632 - Rv1494 - VI nonessential hypothetical protein KEEP 1686570..1686887 1686570 1686887 + 105 15608633 - Rv1495 COG2337T V nonessential hypothetical protein KEEP 1686884..1687888 1686884 1687888 + 334 15608634 - Rv1496 COG1703E III.A nonessential arginine/ornithine transport system ATPase KEEP 1687889..1687940 1687889 1687940 I NA NA IG1521_Rv1496-Rv1497 KEEP 1687941..1689230 1687941 1689230 + 429 15608635 lipL Rv1497 COG1680V II.B.5 nonessential esterase LipL KEEP 1689231..1689302 1689231 1689302 I NA NA IG1522_Rv1497-Rv1498c KEEP 1689303..1689920 1689303 1689920 - 205 15608636 - Rv1498c COG0500QR V nonessential methyltransferase KEEP 1689921..1690133 1689921 1690133 I NA NA IG1523_Rv1498c-Rv1498A KEEP 1690134..1690346 1690134 1690346 - 70 57116877 - Rv1498A COG3360S IV.H nonessential hypothetical protein KEEP 1690347..1690406 1690347 1690406 I NA NA IG1524_Rv1498A-Rv1499 KEEP 1690407..1690805 1690407 1690805 + 132 57116878 - Rv1499 - VI nonessential hypothetical protein KEEP 1690806..1690849 1690806 1690849 I NA NA IG1525_Rv1499-Rv1500 KEEP 1690850..1691878 1690850 1691878 + 342 15608638 - Rv1500 COG0463M IV.H nonessential glycosyltransferase KEEP 1691879..1691889 1691879 1691889 I NA NA IG1526_Rv1500-Rv1501 KEEP 1691890..1692711 1691890 1692711 + 273 15608639 - Rv1501 COG5285Q V nonessential hypothetical protein KEEP 1692712..1692923 1692712 1692923 I NA NA IG1527_Rv1501-Rv1502 KEEP 1692924..1693823 1692924 1693823 + 299 15608640 - Rv1502 COG2152G VI nonessential hypothetical protein KEEP 1693824..1693995 1693824 1693995 I NA NA IG1528_Rv1502-Rv1503c KEEP 1693996..1694544 1693996 1694544 - 182 15608641 - Rv1503c COG0399M V nonessential hypothetical protein KEEP 1694545..1695144 1694545 1695144 - 199 15608642 - Rv1504c COG0399M V nonessential hypothetical protein KEEP 1695145..1695280 1695145 1695280 I NA NA IG1530_Rv1504c-Rv1505c KEEP 1695281..1695946 1695281 1695946 - 221 15608643 - Rv1505c COG0110R V nonessential hypothetical protein KEEP 1695943..1696443 1695943 1696443 - 166 15608644 - Rv1506c COG0500QR VI nonessential hypothetical protein KEEP 1696444..1696726 1696444 1696726 I NA NA IG1532_Rv1506c-Rv1507c KEEP 1696727..1697422 1696727 1697422 - 231 15608645 - Rv1507c - VI nonessential hypothetical protein KEEP 1697356..1697859 1697356 1697859 + 167 57116879 - Rv1507A - V nonessential hypothetical protein KEEP 1697860..1698094 1697860 1698094 I NA NA IG1534_Rv1507A-Rv1508c KEEP 1698095..1699894 1698095 1699862 - 599 15608646 - Rv1508c - V nonessential hypothetical protein KEEP 1698095..1699894 1699863 1699894 - 599 15608646 - Rv1508c - V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 1699866..1700228 1699866 1699920 + 120 57116880 - Rv1508A COG1089M II.C.5 nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 1699866..1700228 1699921 1700228 + 120 57116880 - Rv1508A COG1089M II.C.5 nonessential hypothetical protein KEEP 1700212..1701093 1700212 1701093 + 293 15608647 - Rv1509 COG0500QR VI nonessential hypothetical protein KEEP 1701094..1701294 1701094 1701294 I NA NA IG1537_Rv1509-Rv1510 KEEP 1701295..1702593 1701295 1702155 + 432 15608648 - Rv1510 - II.C.5 nonessential hypothetical protein KEEP 1701295..1702593 1702156 1702206 + 432 15608648 - Rv1510 - II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 1701295..1702593 1702207 1702383 + 432 15608648 - Rv1510 - II.C.5 nonessential hypothetical protein KEEP 1701295..1702593 1702384 1702470 + 432 15608648 - Rv1510 - II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 1701295..1702593 1702471 1702593 + 432 15608648 - Rv1510 - II.C.5 nonessential hypothetical protein KEEP 1702594..1703073 1702594 1702675 I NA NA IG1538_Rv1510-Rv1511 KEEP 1702594..1703073 1702676 1702854 I NA NA IG1538_Rv1510-Rv1511 Only Marin et al 2022 KEEP 1702594..1703073 1702855 1703070 I NA NA IG1538_Rv1510-Rv1511 KEEP 1702594..1703073 1703071 1703073 I NA NA IG1538_Rv1510-Rv1511 Only Marin et al 2022 KEEP 1703074..1704096 1703074 1703128 + 340 15608649 gmdA Rv1511 COG1089M I.C.3 nonessential GDP-D-mannose dehydratase gmdA (GDP-mannose 4,6 dehydratase) (GMD) Only Marin et al 2022 KEEP 1703074..1704096 1703129 1704096 + 340 15608649 gmdA Rv1511 COG1089M I.C.3 nonessential GDP-D-mannose dehydratase gmdA (GDP-mannose 4,6 dehydratase) (GMD) KEEP 1704093..1705061 1704093 1705061 + 322 15608650 epiA Rv1512 COG0451MG I.C.3 nonessential nucleotide-sugar epimerase epiA KEEP 1705058..1705789 1705058 1705789 + 243 15608651 - Rv1513 COG0500QR V nonessential hypothetical protein KEEP 1705790..1705806 1705790 1705806 I NA NA IG1541_Rv1513-Rv1514c KEEP 1705807..1706595 1705807 1706595 - 262 15608652 - Rv1514c COG0463M II.C.2 essential hypothetical protein KEEP 1706596..1706629 1706596 1706629 I NA NA IG1542_Rv1514c-Rv1515c KEEP 1706630..1707526 1706630 1707526 - 298 15608653 - Rv1515c COG0500QR V nonessential hypothetical protein KEEP 1707527..1707528 1707527 1707528 I NA NA IG1543_Rv1515c-Rv1516c KEEP 1707529..1708539 1707529 1708539 - 336 57116881 - Rv1516c COG0463M IV.H nonessential sugar transferase KEEP 1708540..1708870 1708540 1708870 I NA NA IG1544_Rv1516c-Rv1517 KEEP 1708871..1709635 1708871 1709635 + 254 15608655 - Rv1517 - V nonessential hypothetical protein KEEP 1709636..1709643 1709636 1709643 I NA NA IG1545_Rv1517-Rv1518 KEEP 1709644..1710603 1709644 1710603 + 319 15608656 - Rv1518 COG0463M II.C.2 nonessential hypothetical protein KEEP 1710604..1710732 1710604 1710732 I NA NA IG1546_Rv1518-Rv1519 KEEP 1710733..1711002 1710733 1710883 + 89 15608657 - Rv1519 - V nonessential hypothetical protein KEEP 1710733..1711002 1710884 1710945 + 89 15608657 - Rv1519 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 1710733..1711002 1710946 1711002 + 89 15608657 - Rv1519 - V nonessential hypothetical protein KEEP 1711003..1711027 1711003 1711027 I NA NA IG1547_Rv1519-Rv1520 KEEP 1711028..1712068 1711028 1712068 + 346 15608658 - Rv1520 COG0463M IV.H nonessential sugar transferase KEEP 1712069..1712301 1712069 1712301 I NA NA IG1548_Rv1520-Rv1521 KEEP 1712302..1714053 1712302 1712841 + 583 15608659 fadD25 Rv1521 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1712302..1714053 1712842 1712892 + 583 15608659 fadD25 Rv1521 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 1712302..1714053 1712893 1713496 + 583 15608659 fadD25 Rv1521 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1712302..1714053 1713497 1713547 + 583 15608659 fadD25 Rv1521 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 1712302..1714053 1713548 1713672 + 583 15608659 fadD25 Rv1521 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1712302..1714053 1713673 1713753 + 583 15608659 fadD25 Rv1521 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 1712302..1714053 1713754 1714053 + 583 15608659 fadD25 Rv1521 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1714054..1714171 1714054 1714171 I NA NA IG1549_Rv1521-Rv1522c KEEP 1714172..1717612 1714172 1717612 - 1146 15608660 mmpL12 Rv1522c COG2409R II.C.4 nonessential transmembrane transport protein MmpL12 KEEP 1717613..1717652 1717613 1717652 I NA NA IG1550_Rv1522c-Rv1523 KEEP 1717653..1718696 1717653 1718696 + 347 15608661 - Rv1523 COG0500QR IV.H nonessential methyltransferase KEEP 1718697..1718725 1718697 1718725 I NA NA IG1551_Rv1523-Rv1524 KEEP 1718726..1719970 1718726 1719970 + 414 15608662 - Rv1524 COG1819GC IV.H essential glycosyltransferase KEEP 1719971..1720016 1719971 1720016 I NA NA IG1552_Rv1524-Rv1525 KEEP 1720017..1720802 1720017 1720802 + 261 15608663 wbbL2 Rv1525 COG1216R I.C.3 nonessential rhamnosyl transferase WbbL2 KEEP 1720780..1722060 1720780 1722060 - 426 15608664 - Rv1526c COG1819GC IV.H nonessential glycosyltransferase KEEP 1722061..1722082 1722061 1722082 I NA NA IG1554_Rv1526c-Rv1527c KEEP 1722083..1728409 1722083 1722649 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 KEEP 1722083..1728409 1722650 1722700 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 Only Marin et al 2022 KEEP 1722083..1728409 1722701 1722808 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 KEEP 1722083..1728409 1722809 1722890 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 Only Marin et al 2022 KEEP 1722083..1728409 1722891 1723226 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 KEEP 1722083..1728409 1723227 1723284 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 Only Marin et al 2022 KEEP 1722083..1728409 1723285 1723514 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 KEEP 1722083..1728409 1723515 1723595 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 Only Marin et al 2022 KEEP 1722083..1728409 1723596 1725515 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 KEEP 1722083..1728409 1725516 1725566 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 Only Marin et al 2022 KEEP 1722083..1728409 1725567 1728409 - 2108 15608665 pks5 Rv1527c COG3321Q I.I nonessential polyketide synthase pks5 KEEP 1728410..1728952 1728410 1728952 I NA NA IG1555_Rv1527c-Rv1528c KEEP 1728953..1729450 1728953 1729450 - 165 15608666 papA4 Rv1528c - I.I nonessential polyketide synthase associated protein KEEP 1729451..1729501 1729451 1729501 I NA NA IG1556_Rv1528c-Rv1529 KEEP 1729502..1731256 1729502 1730044 + 584 15608667 fadD24 Rv1529 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1729502..1731256 1730045 1730095 + 584 15608667 fadD24 Rv1529 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 1729502..1731256 1730096 1730875 + 584 15608667 fadD24 Rv1529 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1729502..1731256 1730876 1730956 + 584 15608667 fadD24 Rv1529 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 1729502..1731256 1730957 1731134 + 584 15608667 fadD24 Rv1529 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1729502..1731256 1731135 1731203 + 584 15608667 fadD24 Rv1529 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 1729502..1731256 1731204 1731256 + 584 15608667 fadD24 Rv1529 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1731257..1731372 1731257 1731372 I NA NA IG1557_Rv1529-Rv1530 KEEP 1731373..1732476 1731373 1732476 + 367 15608668 adh Rv1530 COG1063ER I.B.7 nonessential alcohol dehydrogenase adh KEEP 1732473..1733039 1732473 1733039 + 188 15608669 - Rv1531 COG2128S V nonessential hypothetical protein KEEP 1733040..1733115 1733040 1733115 I NA NA IG1559_Rv1531-Rv1532c KEEP 1733116..1733550 1733116 1733550 - 144 15608670 - Rv1532c COG2050Q V nonessential hypothetical protein KEEP 1733551..1733609 1733551 1733609 I NA NA IG1560_Rv1532c-Rv1533 KEEP 1733610..1734737 1733610 1734737 + 375 15608671 - Rv1533 COG2070R V nonessential hypothetical protein KEEP 1734734..1735411 1734734 1735411 + 225 15608672 - Rv1534 COG1309K I.J.1 nonessential transcriptional regulator KEEP 1735412..1735975 1735412 1735540 I NA NA IG1562_Rv1534-Rv1535 KEEP 1735412..1735975 1735541 1735635 I NA NA IG1562_Rv1534-Rv1535 Only Marin et al 2022 KEEP 1735412..1735975 1735636 1735975 I NA NA IG1562_Rv1534-Rv1535 KEEP 1735976..1736212 1735976 1736212 + 78 15608673 - Rv1535 - VI nonessential hypothetical protein KEEP 1736213..1736518 1736213 1736518 I NA NA IG1563_Rv1535-Rv1536 KEEP 1736519..1739644 1736519 1739644 + 1041 15608674 ileS Rv1536 COG0060J II.A.3 nonessential isoleucyl-tRNA synthetase KEEP 1739645..1739840 1739645 1739840 I NA NA IG1564_Rv1536-Rv1537 KEEP 1739841..1741247 1739841 1741247 + 468 161352466 dinX Rv1537 COG0389L II.A.5 nonessential DNA polymerase IV KEEP 1741212..1742192 1741212 1742192 - 326 15608676 ansA Rv1538c COG0252EJ I.A.2 nonessential L-aparaginase ansA KEEP 1742193..1742243 1742193 1742243 I NA NA IG1566_Rv1538c-Rv1539 KEEP 1742244..1742852 1742244 1742852 + 202 15608677 lspA Rv1539 COG0597MU III.D essential lipoprotein signal peptidase KEEP 1742845..1743771 1742845 1743771 + 308 15608678 - Rv1540 COG0564J V nonessential hypothetical protein KEEP 1743772..1743777 1743772 1743777 I NA NA IG1568_Rv1540-Rv1541c KEEP 1743778..1744371 1743778 1744371 - 197 15608679 lprI Rv1541c COG3895R,COG4461S II.C.1 nonessential lipoprotein LprI KEEP 1744372..1744425 1744372 1744425 I NA NA IG1569_Rv1541c-Rv1542c KEEP 1744426..1744836 1744426 1744836 - 136 15608680 glbN Rv1542c COG2346R I.B.6a nonessential hemoglobin glbN KEEP 1744837..1745063 1744837 1745063 I NA NA IG1570_Rv1542c-Rv1543 KEEP 1745064..1746089 1745064 1746089 + 341 15608681 - Rv1543 COG1028IQR I.H.3 nonessential fatty acyl-CoA reductase KEEP 1746090..1746093 1746090 1746093 I NA NA IG1571_Rv1543-Rv1544 KEEP 1746094..1746897 1746094 1746897 + 267 15608682 - Rv1544 COG0300R I.I nonessential ketoacyl reductase KEEP 1746898..1746918 1746898 1746918 I NA NA IG1572_Rv1544-Rv1545 KEEP 1746919..1747146 1746919 1747146 + 75 15608683 - Rv1545 - VI nonessential hypothetical protein KEEP 1747147..1747194 1747147 1747194 I NA NA IG1573_Rv1545-Rv1546 KEEP 1747195..1747626 1747195 1747626 + 143 15608684 - Rv1546 - V nonessential hypothetical protein KEEP 1747627..1747693 1747627 1747693 I NA NA IG1574_Rv1546-Rv1547 KEEP 1747694..1751248 1747694 1751248 + 1184 15608685 dnaE Rv1547 COG0587L II.A.5 essential DNA polymerase III subunit alpha KEEP 1751249..1751296 1751249 1751296 I NA NA IG1575_Rv1547-Rv1548c KEEP 1751297..1753333 1751297 1753011 - 678 57116882 PPE21 Rv1548c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1751297..1753333 1753012 1753062 - 678 57116882 PPE21 Rv1548c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1751297..1753333 1753063 1753286 - 678 57116882 PPE21 Rv1548c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1751297..1753333 1753287 1753333 - 678 57116882 PPE21 Rv1548c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1753334..1753509 1753334 1753337 I NA NA IG1576_Rv1548c-Rv1549 Annotation + Marin et al 2022 DISCARD 1753334..1753509 1753338 1753509 I NA NA IG1576_Rv1548c-Rv1549 KEEP 1753510..1754037 1753510 1754037 + 175 57116883 fadD11.1 Rv1549 COG1022I I.A.3 nonessential fatty-acid-CoA ligase KEEP 1753716..1755431 1753716 1755431 + 571 15608688 fadD11 Rv1550 COG1022I I.A.3 nonessential fatty-acid-CoA ligase KEEP 1755432..1755444 1755432 1755444 I NA NA IG1578_Rv1550-Rv1551 KEEP 1755445..1757310 1755445 1757310 + 621 15608689 plsB1 Rv1551 COG2937I I.H.3 nonessential glycerol-3-phosphate acyltransferase KEEP 1757311..1757680 1757311 1757680 I NA NA IG1579_Rv1551-Rv1552 KEEP 1757681..1759432 1757681 1759432 + 583 15608690 frdA Rv1552 COG1053C I.B.6b nonessential fumarate reductase flavoprotein subunit KEEP 1759433..1759434 1759433 1759434 I NA NA IG1580_Rv1552-Rv1553 KEEP 1759435..1760178 1759435 1760178 + 247 15608691 frdB Rv1553 COG0479C I.B.6b nonessential fumarate reductase iron-sulfur subunit FrdB KEEP 1760175..1760555 1760175 1760555 + 126 15608692 frdC Rv1554 COG3029C I.B.6b nonessential fumarate reductase subunit C KEEP 1760552..1760929 1760552 1760929 + 125 15608693 frdD Rv1555 - I.B.6b nonessential fumarate reductase subunit D KEEP 1760930..1760996 1760930 1760996 I NA NA IG1583_Rv1555-Rv1556 KEEP 1760997..1761605 1760997 1761605 + 202 15608694 - Rv1556 COG1309K I.J.1 nonessential regulatory protein KEEP 1761606..1761743 1761606 1761743 I NA NA IG1584_Rv1556-Rv1557 KEEP 1761744..1762937 1761744 1762937 + 397 15608695 mmpL6 Rv1557 COG2409R II.C.4 nonessential transmembrane transport protein MmpL6 KEEP 1762938..1762946 1762938 1762946 I NA NA IG1585_Rv1557-Rv1558 KEEP 1762947..1763393 1762947 1763393 + 148 15608696 - Rv1558 - V nonessential hypothetical protein KEEP 1763394..1763427 1763394 1763427 I NA NA IG1586_Rv1558-Rv1559 KEEP 1763428..1764717 1763428 1764717 + 429 15608697 ilvA Rv1559 COG1171E I.D.7 nonessential threonine dehydratase KEEP 1764718..1764754 1764718 1764754 I NA NA IG1587_Rv1559-Rv1560 KEEP 1764755..1764973 1764755 1764973 + 72 15608698 - Rv1560 COG5450K V essential hypothetical protein KEEP 1764974..1764978 1764974 1764978 I NA NA IG1588_Rv1560-Rv1561 KEEP 1764979..1765383 1764979 1765383 + 134 15608699 - Rv1561 COG1487R V nonessential hypothetical protein KEEP 1765384..1765399 1765384 1765399 I NA NA IG1589_Rv1561-Rv1562c KEEP 1765400..1767142 1765400 1767142 - 580 57116884 treZ Rv1562c COG0296G II.A.8 nonessential maltooligosyltrehalose trehalohydrolase TreZ KEEP 1767135..1769432 1767135 1769432 - 765 57116885 treY Rv1563c COG3280G II.A.8 nonessential maltooligosyltrehalose synthase TreY KEEP 1769433..1769435 1769433 1769435 I NA NA IG1591_Rv1563c-Rv1564c KEEP 1769436..1771601 1769436 1771601 - 721 57116886 treX Rv1564c COG1523G II.A.8 nonessential maltooligosyltrehalose synthase TreX KEEP 1771602..1771639 1771602 1771639 I NA NA IG1592_Rv1564c-Rv1565c KEEP 1771640..1773829 1771640 1773829 - 729 15608703 - Rv1565c COG1835I V nonessential hypothetical protein KEEP 1773830..1773927 1773830 1773927 I NA NA IG1593_Rv1565c-Rv1566c KEEP 1773928..1774620 1773928 1773951 - 230 15608704 - Rv1566c COG0791M IV.A nonessential inv protein KEEP 1773928..1774620 1773952 1774109 - 230 15608704 - Rv1566c COG0791M IV.A nonessential inv protein Marin et al 2022 + homoplasy analysis DISCARD 1773928..1774620 1774110 1774620 - 230 15608704 - Rv1566c COG0791M IV.A nonessential inv protein KEEP 1774621..1774859 1774621 1774859 I NA NA IG1594_Rv1566c-Rv1567c KEEP 1774860..1775144 1774860 1775144 - 94 15608705 - Rv1567c - VI nonessential hypothetical protein KEEP 1775145..1775391 1775145 1775391 I NA NA IG1595_Rv1567c-Rv1568 KEEP 1775392..1776705 1775392 1776705 + 437 15608706 bioA Rv1568 COG0161H I.G.1 essential adenosylmethionine--8-amino-7-oxononanoate transaminase KEEP 1776702..1777862 1776702 1777862 + 386 57116887 bioF1 Rv1569 COG0156H I.G.1 essential 8-amino-7-oxononanoate synthase KEEP 1777859..1778539 1777859 1778539 + 226 15608708 bioD Rv1570 COG0132H I.G.1 nonessential dithiobiotin synthetase KEEP 1778539..1779048 1778539 1779048 + 169 15608709 - Rv1571 - V nonessential hypothetical protein KEEP 1779049..1779193 1779049 1779193 I NA NA IG1599_Rv1571-Rv1572c KEEP 1779194..1779298 1779194 1779265 - 34 57116888 - Rv1572c - V repeat13E12 nonessential hypothetical protein KEEP 1779194..1779298 1779266 1779298 - 34 57116888 - Rv1572c - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 1779299..1779313 1779299 1779313 I NA NA IG1600_Rv1572c-Rv1573 repeat Annotation + Marin et al 2022 DISCARD 1779314..1779724 1779314 1779724 + 136 15608711 - Rv1573 - IV.B.3 phage nonessential phiRV1 phage protein Annotation + Marin et al 2022 DISCARD 1779725..1779929 1779725 1779929 I NA NA IG1601_Rv1573-Rv1574 repeat Annotation + Marin et al 2022 DISCARD 1779930..1780241 1779930 1780241 + 103 15608712 - Rv1574 - IV.B.3 phage nonessential phiRV1 phage related protein Annotation + Marin et al 2022 DISCARD 1780199..1780699 1780199 1780699 + 166 57116889 - Rv1575 - IV.B.3 phage nonessential phiRV1 phage protein Annotation + Marin et al 2022 DISCARD 1780643..1782064 1780643 1782064 - 473 15608714 - Rv1576c COG4653R IV.B.3 phage nonessential phiRV1 phage protein Annotation + Marin et al 2022 DISCARD 1782065..1782071 1782065 1782071 I NA NA IG1604_Rv1576c-Rv1577c repeat Annotation + Marin et al 2022 DISCARD 1782072..1782584 1782072 1782584 - 170 15608715 - Rv1577c COG3740R IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1782585..1782757 1782585 1782757 I NA NA IG1605_Rv1577c-Rv1578c repeat Annotation + Marin et al 2022 DISCARD 1782758..1783228 1782758 1783228 - 156 15608716 - Rv1578c COG3747L IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1783229..1783308 1783229 1783308 I NA NA IG1606_Rv1578c-Rv1579c repeat Annotation + Marin et al 2022 DISCARD 1783309..1783623 1783309 1783623 - 104 15608717 - Rv1579c - IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1783620..1783892 1783620 1783892 - 90 15608718 - Rv1580c - IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1783893..1783905 1783893 1783905 I NA NA IG1608_Rv1580c-Rv1581c repeat Annotation + Marin et al 2022 DISCARD 1783906..1784301 1783906 1784301 - 131 15608719 - Rv1581c - IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1784302..1784496 1784302 1784496 I NA NA IG1609_Rv1581c-Rv1582c repeat Annotation + Marin et al 2022 DISCARD 1784497..1785912 1784497 1785912 - 471 15608720 - Rv1582c COG3378R IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1785912..1786310 1785912 1786310 - 132 15608721 - Rv1583c - IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1786307..1786528 1786307 1786528 - 73 15608722 - Rv1584c - IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1786529..1786583 1786529 1786583 I NA NA IG1612_Rv1584c-Rv1585c repeat Annotation + Marin et al 2022 DISCARD 1786584..1787099 1786584 1787099 - 171 15608723 - Rv1585c - IV.B.3 phage nonessential phiRv1 phage protein Annotation + Marin et al 2022 DISCARD 1787096..1788505 1787096 1788505 - 469 15608724 - Rv1586c COG1961L IV.B.3 phage nonessential phiRv1 integrase Annotation + Marin et al 2022 DISCARD 1788162..1789163 1788162 1789163 - 333 57116890 - Rv1587c - VI repeat13E12 nonessential REP13E12 repeat-containing protein Annotation + Marin et al 2022 DISCARD 1789164..1789167 1789164 1789167 I NA NA IG1615_Rv1587c-Rv1588c repeat Annotation + Marin et al 2022 DISCARD 1789168..1789836 1789168 1789836 - 222 15608726 - Rv1588c - VI repeat13E12 nonessential REP13E12 repeat-containing protein Annotation + Marin et al 2022 DISCARD 1789837..1790283 1789837 1789872 I NA NA IG1616_Rv1588c-Rv1589 Annotation + Marin et al 2022 DISCARD 1789837..1790283 1789873 1790283 I NA NA IG1616_Rv1588c-Rv1589 KEEP 1790284..1791333 1790284 1791333 + 349 15608727 bioB Rv1589 COG0502H I.G.1 essential biotin synthase KEEP 1791334..1791573 1791334 1791573 + 79 15608728 - Rv1590 - V essential hypothetical protein KEEP 1791570..1792235 1791570 1792235 + 221 15608729 - Rv1591 - II.C.5 nonessential hypothetical protein KEEP 1792236..1792399 1792236 1792399 I NA NA IG1619_Rv1591-Rv1592c KEEP 1792400..1793740 1792400 1793740 - 446 15608730 - Rv1592c - V DR-inh nonessential hypothetical protein KEEP 1793741..1793996 1793741 1793996 I NA NA IG1620_Rv1592c-Rv1593c DR-inh KEEP 1793997..1794707 1793997 1794707 - 236 15608731 - Rv1593c COG1051F V nonessential hypothetical protein KEEP 1794708..1794755 1794708 1794755 I NA NA IG1621_Rv1593c-Rv1594 KEEP 1794756..1795805 1794756 1795805 + 349 15608732 nadA Rv1594 COG0379H I.G.7 essential quinolinate synthetase KEEP 1795805..1797388 1795805 1797388 + 527 15608733 nadB Rv1595 COG0029H I.G.7 essential L-aspartate oxidase KEEP 1797388..1798245 1797388 1798245 + 285 15608734 nadC Rv1596 COG0157H I.G.7 nonessential nicotinate-nucleotide pyrophosphorylase KEEP 1798246..1798293 1798246 1798293 I NA NA IG1624_Rv1596-Rv1597 KEEP 1798294..1799052 1798294 1799052 + 252 15608735 - Rv1597 COG0500QR VI nonessential hypothetical protein KEEP 1799053..1799072 1799053 1799072 I NA NA IG1625_Rv1597-Rv1598c KEEP 1799073..1799483 1799073 1799483 - 136 15608736 - Rv1598c - V nonessential hypothetical protein KEEP 1799484..1799582 1799484 1799582 I NA NA IG1626_Rv1598c-Rv1599 KEEP 1799583..1800899 1799583 1800899 + 438 15608737 hisD Rv1599 COG0141E I.D.5 essential histidinol dehydrogenase KEEP 1800896..1802038 1800896 1802038 + 380 57116891 hisC1 Rv1600 COG0079E I.D.5 essential histidinol-phosphate aminotransferase KEEP 1802035..1802667 1802035 1802667 + 210 15608739 hisB Rv1601 COG0131E I.D.5 essential imidazoleglycerol-phosphate dehydratase KEEP 1802664..1803284 1802664 1803284 + 206 15608740 hisH Rv1602 COG0118E I.D.5 essential imidazole glycerol phosphate synthase subunit HisH KEEP 1803285..1803293 1803285 1803293 I NA NA IG1630_Rv1602-Rv1603 KEEP 1803294..1804031 1803294 1804031 + 245 15608741 hisA Rv1603 COG0106E I.D.5 essential 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase KEEP 1804032..1804038 1804032 1804038 I NA NA IG1631_Rv1603-Rv1604 KEEP 1804039..1804851 1804039 1804851 + 270 15608742 impA Rv1604 COG0483G IV.I nonessential inositol-monophosphatase KEEP 1804853..1805656 1804853 1805656 + 267 15608743 hisF Rv1605 COG0107E I.D.5 essential imidazole glycerol phosphate synthase subunit HisF KEEP 1805653..1806000 1805653 1806000 + 115 57116892 hisI Rv1606 COG0139E I.D.5 essential phosphoribosyl-AMP cyclohydrolase KEEP 1806001..1806180 1806001 1806180 I NA NA IG1634_Rv1606-Rv1607 KEEP 1806181..1807263 1806181 1807263 + 360 15608745 chaA Rv1607 COG0387P III.A.2 nonessential ionic transporter integral membrane protein chaA KEEP 1807264..1807297 1807264 1807297 I NA NA IG1635_Rv1607-Rv1608c KEEP 1807298..1807762 1807298 1807762 - 154 15608746 bcpB Rv1608c COG1225O III.F nonessential peroxidoxin BcpB KEEP 1807763..1807902 1807763 1807902 I NA NA IG1636_Rv1608c-Rv1609 KEEP 1807903..1809453 1807903 1809453 + 516 15608747 trpE Rv1609 COG0147EH I.D.4 essential anthranilate synthase component I KEEP 1809443..1810150 1809443 1810150 + 235 15608748 - Rv1610 - II.C.5 essential hypothetical protein KEEP 1810151..1810239 1810151 1810239 I NA NA IG1638_Rv1610-Rv1611 KEEP 1810240..1811058 1810240 1811058 + 272 15608749 trpC Rv1611 COG0134E I.D.4 essential indole-3-glycerol-phosphate synthase KEEP 1811059..1811126 1811059 1811126 I NA NA IG1639_Rv1611-Rv1612 KEEP 1811127..1812359 1811127 1812359 + 410 15608750 trpB Rv1612 COG0133E I.D.4 essential tryptophan synthase subunit beta KEEP 1812359..1813171 1812359 1813171 + 270 15608751 trpA Rv1613 COG0159E I.D.4 essential tryptophan synthase subunit alpha KEEP 1813171..1814577 1813171 1814577 + 468 15608752 lgt Rv1614 COG0682M III.D essential prolipoprotein diacylglyceryl transferase KEEP 1814578..1815252 1814578 1814849 I NA NA IG1642_Rv1614-Rv1615 KEEP 1814578..1815252 1814850 1815130 I NA NA IG1642_Rv1614-Rv1615 Only Marin et al 2022 KEEP 1814578..1815252 1815131 1815252 I NA NA IG1642_Rv1614-Rv1615 KEEP 1815253..1815693 1815253 1815693 + 146 15608753 - Rv1615 COG2314S VI nonessential hypothetical protein KEEP 1815683..1816081 1815683 1816081 + 132 15608754 - Rv1616 - II.C.5 nonessential hypothetical protein KEEP 1816082..1816188 1816082 1816188 I NA NA IG1644_Rv1616-Rv1617 KEEP 1816189..1817607 1816189 1817607 + 472 15608755 pykA Rv1617 COG0469G I.B.1 essential pyruvate kinase KEEP 1817608..1817614 1817608 1817614 I NA NA IG1645_Rv1617-Rv1618 KEEP 1817615..1818517 1817615 1818517 + 300 15608756 tesB1 Rv1618 COG1946I I.H.1 nonessential acyl-CoA thioesterase II TesB1 KEEP 1818518..1818574 1818518 1818574 I NA NA IG1646_Rv1618-Rv1619 KEEP 1818575..1820029 1818575 1820029 + 484 15608757 - Rv1619 COG2898S II.C.5 nonessential hypothetical protein KEEP 1819963..1821693 1819963 1821693 - 576 15608758 cydC Rv1620c COG1132V I.B.6c nonessential cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC KEEP 1821690..1823273 1821690 1823273 - 527 15608759 cydD Rv1621c COG4988CO I.B.6c nonessential vytochrome' transport transmembrane ATP-binding protein ABC transporter CydD KEEP 1823274..1823359 1823274 1823359 I NA NA IG1649_Rv1621c-Rv1622c KEEP 1823360..1824400 1823360 1824400 - 346 15608760 cydB Rv1622c COG1294C I.B.6c essential integral membrane cytochrome D ubiquinol oxidase (subunit II) cydB (cytochrome bd-I oxidase subunit II) KEEP 1824401..1824429 1824401 1824429 I NA NA IG1650_Rv1622c-Rv1623c KEEP 1824430..1825887 1824430 1825887 - 485 57116893 cydA Rv1623c COG1271C I.B.6c nonessential integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA (cytochrome bd-I oxidase subunit I) KEEP 1825888..1825997 1825888 1825997 I NA NA IG1651_Rv1623c-Rv1624c KEEP 1825998..1826585 1825998 1826585 - 195 15608762 - Rv1624c COG3247S II.C.4 nonessential hypothetical protein KEEP 1826586..1826613 1826586 1826613 I NA NA IG1652_Rv1624c-Rv1625c KEEP 1826614..1827945 1826614 1827945 - 443 57116894 cya Rv1625c COG2114T II.C.5 nonessential membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase) KEEP 1827946..1828179 1827946 1828179 I NA NA IG1653_Rv1625c-Rv1626 KEEP 1828180..1828797 1828180 1828797 + 205 15608764 - Rv1626 COG3707T I.J.2 essential two-component system transcriptional regulator KEEP 1828798..1828864 1828798 1828799 I NA NA IG1654_Rv1626-Rv1627c KEEP 1828798..1828864 1828800 1828860 I NA NA IG1654_Rv1626-Rv1627c Only Marin et al 2022 KEEP 1828798..1828864 1828861 1828864 I NA NA IG1654_Rv1626-Rv1627c KEEP 1828865..1830073 1828865 1830065 - 402 15608765 - Rv1627c COG0183I I.H.3 nonessential lipid-transfer protein KEEP 1828865..1830073 1830066 1830073 - 402 15608765 - Rv1627c COG0183I I.H.3 nonessential lipid-transfer protein Only Marin et al 2022 KEEP 1830070..1830561 1830070 1830125 - 163 15608766 - Rv1628c COG1545R V nonessential hypothetical protein Only Marin et al 2022 KEEP 1830070..1830561 1830126 1830561 - 163 15608766 - Rv1628c COG1545R V nonessential hypothetical protein KEEP 1830562..1830664 1830562 1830664 I NA NA IG1656_Rv1628c-Rv1629 KEEP 1830665..1833379 1830665 1833379 + 904 15608767 polA Rv1629 COG0258L,COG0749L II.A.5 essential DNA polymerase I KEEP 1833380..1833541 1833380 1833541 I NA NA IG1657_Rv1629-Rv1630 KEEP 1833542..1834987 1833542 1834987 + 481 15608768 rpsA Rv1630 COG0539J II.A.1 essential 30S ribosomal protein S1 KEEP 1834988..1835012 1834988 1835012 I NA NA IG1658_Rv1630-Rv1631 KEEP 1835013..1836236 1835013 1836236 + 407 15608769 coaE Rv1631 COG0237H,COG2320S VII essential fused dephospho-CoA kinase/unknown domain-containing protein KEEP 1836237..1836386 1836237 1836386 I NA NA IG1659_Rv1631-Rv1632c KEEP 1836387..1836830 1836387 1836830 - 147 15608770 - Rv1632c COG2306S VI nonessential hypothetical protein KEEP 1836831..1837074 1836831 1837074 I NA NA IG1660_Rv1632c-Rv1633 KEEP 1837075..1839171 1837075 1839171 + 698 15608771 uvrB Rv1633 COG0556L II.A.5 nonessential excinuclease ABC subunit B KEEP 1839168..1840583 1839168 1840583 + 471 15608772 - Rv1634 COG0477GEPR III.A.6 nonessential drug efflux membrane protein KEEP 1840572..1842242 1840572 1842242 - 556 15608773 - Rv1635c - II.C.5 nonessential transmembrane protein KEEP 1842243..1842450 1842243 1842450 I NA NA IG1663_Rv1635c-Rv1636 KEEP 1842451..1842891 1842451 1842891 + 146 15608774 TB15.3 Rv1636 COG0589T V nonessential hypothetical protein KEEP 1842892..1842897 1842892 1842897 I NA NA IG1664_Rv1636-Rv1637c KEEP 1842898..1843692 1842898 1843692 - 264 15608775 - Rv1637c COG0491R V nonessential hypothetical protein KEEP 1843693..1843740 1843693 1843740 I NA NA IG1665_Rv1637c-Rv1638 KEEP 1843741..1846659 1843741 1846659 + 972 15608776 uvrA Rv1638 COG0178L II.A.5 nonessential excinuclease ABC subunit A KEEP 1846660..1846715 1846660 1846715 I NA NA IG1666_Rv1638-Rv1638A KEEP 1846716..1846973 1846716 1846973 - 85 57116895 - Rv1638A COG1842KT V nonessential hypothetical protein KEEP 1846974..1846988 1846974 1846988 I NA NA IG1667_Rv1638A-Rv1639c KEEP 1846989..1848458 1846989 1848458 - 489 15608777 - Rv1639c COG0627R V nonessential hypothetical protein KEEP 1848459..1848516 1848459 1848516 I NA NA IG1668_Rv1639c-Rv1640c KEEP 1848517..1852035 1848517 1852035 - 1172 15608778 lysS Rv1640c COG1190J,COG2898S II.A.3 essential lysyl-tRNA synthetase KEEP 1852036..1852272 1852036 1852272 I NA NA IG1669_Rv1640c-Rv1641 KEEP 1852273..1852878 1852273 1852878 + 201 15608779 infC Rv1641 COG0290J II.A.6 essential translation initiation factor IF-3 KEEP 1852879..1852927 1852879 1852927 I NA NA IG1670_Rv1641-Rv1642 KEEP 1852928..1853122 1852928 1853122 + 64 15608780 rpmI Rv1642 COG0291J II.A.1 nonessential 50S ribosomal protein L35 KEEP 1853123..1853183 1853123 1853183 I NA NA IG1671_Rv1642-Rv1643 KEEP 1853184..1853573 1853184 1853573 + 129 15608781 rplT Rv1643 COG0292J II.A.1 nonessential 50S ribosomal protein L20 KEEP 1853574..1853605 1853574 1853605 I NA NA IG1672_Rv1643-Rv1644 KEEP 1853606..1854388 1853606 1854388 + 260 15608782 tsnR Rv1644 COG0566J II.A.7 nonessential 23S rRNA methyltransferase TsnR KEEP 1854389..1854398 1854389 1854398 I NA NA IG1673_Rv1644-Rv1645c KEEP 1854399..1855454 1854399 1855454 - 351 15608783 - Rv1645c COG3662S V nonessential hypothetical protein KEEP 1855455..1855763 1855455 1855763 I NA NA IG1674_Rv1645c-Rv1646 KEEP 1855764..1856696 1855764 1856696 + 310 57116896 PE17 Rv1646 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 1856697..1856773 1856697 1856773 I NA NA IG1675_Rv1646-Rv1647 KEEP 1856774..1857724 1856774 1857724 + 316 15608785 - Rv1647 COG2114T V nonessential hypothetical protein KEEP 1857725..1857730 1857725 1857730 I NA NA IG1676_Rv1647-Rv1648 KEEP 1857731..1858537 1857731 1858537 + 268 15608786 - Rv1648 - II.C.5 nonessential transmembrane protein KEEP 1858538..1858732 1858538 1858732 I NA NA IG1677_Rv1648-Rv1649 KEEP 1858733..1859758 1858733 1859758 + 341 15608787 pheS Rv1649 COG0016J II.A.3 essential phenylalanyl-tRNA synthetase subunit alpha KEEP 1859758..1862253 1859758 1862253 + 831 15608788 pheT Rv1650 COG0072J,COG0073R II.A.3 essential phenylalanyl-tRNA synthetase subunit beta KEEP 1862254..1862346 1862254 1862346 I NA NA IG1679_Rv1650-Rv1651c KEEP 1862347..1865382 1862347 1863480 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1863481 1863575 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1863576 1863722 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1863723 1863733 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1863734 1864007 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1864008 1864112 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1864113 1864255 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1864256 1864323 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1864324 1864393 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1864394 1864468 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1864469 1864553 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1864554 1864580 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1864581 1864701 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1864702 1864872 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1864873 1864884 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1864885 1864924 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1864925 1865011 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1862347..1865382 1865012 1865070 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1862347..1865382 1865071 1865382 - 1011 57116897 PE_PGRS30 Rv1651c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1865383..1865575 1865383 1865575 I NA NA IG1680_Rv1651c-Rv1652 KEEP 1865576..1866634 1865576 1866634 + 352 15608790 argC Rv1652 COG0002E I.D.1 essential N-acetyl-gamma-glutamyl-phosphate reductase KEEP 1866631..1867845 1866631 1867845 + 404 15608791 argJ Rv1653 COG1364E I.D.1 essential bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein KEEP 1867842..1868726 1867842 1868726 + 294 15608792 argB Rv1654 COG0548E I.D.1 essential acetylglutamate kinase KEEP 1868723..1869925 1868723 1869925 + 400 15608793 argD Rv1655 COG4992E I.D.1 essential acetylornithine aminotransferase KEEP 1869922..1870845 1869922 1870845 + 307 15608794 argF Rv1656 COG0078E I.D.1 essential ornithine carbamoyltransferase KEEP 1870842..1871354 1870842 1871354 + 170 15608795 argR Rv1657 COG1438K I.J.1 nonessential arginine repressor KEEP 1871355..1871362 1871355 1871362 I NA NA IG1686_Rv1657-Rv1658 KEEP 1871363..1872559 1871363 1872559 + 398 15608796 argG Rv1658 COG0137E I.D.1 essential argininosuccinate synthase KEEP 1872560..1872638 1872560 1872638 I NA NA IG1687_Rv1658-Rv1659 KEEP 1872639..1874051 1872639 1874051 + 470 15608797 argH Rv1659 COG0165E I.D.1 essential argininosuccinate lyase KEEP 1874052..1874159 1874052 1874159 I NA NA IG1688_Rv1659-Rv1660 KEEP 1874160..1875221 1874160 1875221 + 353 15608798 pks10 Rv1660 COG3424Q I.I nonessential chalcone synthase KEEP 1875222..1875303 1875222 1875303 I NA NA IG1689_Rv1660-Rv1661 KEEP 1875304..1881684 1875304 1875414 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1875415 1875504 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1875505 1875876 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1875877 1875967 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1875968 1876149 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1876150 1876234 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1876235 1876403 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1876404 1876592 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1876593 1876599 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1876600 1876674 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1876675 1879286 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1879287 1879381 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1879382 1879424 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1879425 1879426 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1879427 1879493 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1879494 1879619 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1879620 1879630 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1879631 1879638 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1879639 1879649 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1879650 1879659 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1879660 1880679 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1880680 1880748 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1880749 1880755 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1880756 1880809 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1880810 1880822 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1880823 1880877 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1880878 1880883 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1875304..1881684 1880884 1880943 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 Only Marin et al 2022 KEEP 1875304..1881684 1880944 1881684 + 2126 15608799 pks7 Rv1661 COG3321Q I.I essential polyketide synthase pks7 KEEP 1881685..1881703 1881685 1881703 I NA NA IG1690_Rv1661-Rv1662 KEEP 1881704..1886512 1881704 1881811 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1881812 1881901 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1881902 1882243 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1882244 1882358 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1882359 1882540 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1882541 1882625 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1882626 1882693 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1882694 1882760 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1882761 1882791 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1882792 1882979 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1882980 1882987 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1882988 1883062 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1883063 1883353 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1883354 1883404 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1883405 1885849 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1885850 1885902 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1885903 1886334 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1881704..1886512 1886335 1886387 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 Only Marin et al 2022 KEEP 1881704..1886512 1886388 1886512 + 1602 15608800 pks8 Rv1662 COG3321Q I.I essential polyketide synthase pks8 KEEP 1886512..1888020 1886512 1886689 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 KEEP 1886512..1888020 1886690 1886751 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 Only Marin et al 2022 KEEP 1886512..1888020 1886752 1886988 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 KEEP 1886512..1888020 1886989 1887057 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 Only Marin et al 2022 KEEP 1886512..1888020 1887058 1887064 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 KEEP 1886512..1888020 1887065 1887118 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 Only Marin et al 2022 KEEP 1886512..1888020 1887119 1887131 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 KEEP 1886512..1888020 1887132 1887186 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 Only Marin et al 2022 KEEP 1886512..1888020 1887187 1887192 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 KEEP 1886512..1888020 1887193 1887252 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 Only Marin et al 2022 KEEP 1886512..1888020 1887253 1888020 + 502 15608801 pks17 Rv1663 COG3321Q I.I essential polyketide synthase pks17 KEEP 1888021..1888025 1888021 1888025 I NA NA IG1692_Rv1663-Rv1664 KEEP 1888026..1891079 1888026 1889504 + 1017 15608802 pks9 Rv1664 COG3321Q I.I nonessential polyketide synthase pks9 KEEP 1888026..1891079 1889505 1889555 + 1017 15608802 pks9 Rv1664 COG3321Q I.I nonessential polyketide synthase pks9 Only Marin et al 2022 KEEP 1888026..1891079 1889556 1891079 + 1017 15608802 pks9 Rv1664 COG3321Q I.I nonessential polyketide synthase pks9 KEEP 1891080..1891225 1891080 1891225 I NA NA IG1693_Rv1664-Rv1665 KEEP 1891226..1892287 1891226 1892287 + 353 15608803 pks11 Rv1665 COG3424Q I.I nonessential chalcone synthase KEEP 1892270..1893562 1892270 1893562 - 430 15608804 cyp139 Rv1666c COG2124Q IV.F nonessential cytochrome P450 139 CYP139 KEEP 1893563..1893576 1893563 1893576 I NA NA IG1695_Rv1666c-Rv1667c KEEP 1893577..1894230 1893577 1894230 - 217 15608805 - Rv1667c COG0488R III.A nonessential macrolide-transport ATP-binding protein ABC transporter KEEP 1894224..1895342 1894224 1895342 - 372 15608806 - Rv1668c COG0488R III.A nonessential macrolide-transport ATP-binding protein ABC transporter KEEP 1895343..1895724 1895343 1895346 I NA NA IG1697_Rv1668c-Rv1669 KEEP 1895343..1895724 1895347 1895599 I NA NA IG1697_Rv1668c-Rv1669 Only Marin et al 2022 KEEP 1895343..1895724 1895600 1895724 I NA NA IG1697_Rv1668c-Rv1669 KEEP 1895725..1896087 1895725 1896087 + 120 15608807 - Rv1669 - VI nonessential hypothetical protein KEEP 1896088..1896119 1896088 1896119 I NA NA IG1698_Rv1669-Rv1670 KEEP 1896120..1896467 1896120 1896467 + 115 15608808 - Rv1670 COG2343S V nonessential hypothetical protein KEEP 1896468..1896474 1896468 1896474 I NA NA IG1699_Rv1670-Rv1671 KEEP 1896475..1896867 1896475 1896867 + 130 15608809 - Rv1671 - II.C.5 nonessential hypothetical protein KEEP 1896868..1896875 1896868 1896875 I NA NA IG1700_Rv1671-Rv1672c KEEP 1896876..1898207 1896876 1898207 - 443 15608810 - Rv1672c COG0477GEPR II.C.5 nonessential integral membrane transport protein KEEP 1898208..1898299 1898208 1898299 I NA NA IG1701_Rv1672c-Rv1673c KEEP 1898300..1899232 1898300 1899232 - 310 15608811 - Rv1673c COG1305E V nonessential hypothetical protein KEEP 1899233..1899259 1899233 1899259 I NA NA IG1702_Rv1673c-Rv1674c KEEP 1899260..1899916 1899260 1899916 - 218 15608812 - Rv1674c COG0607P,COG0640K I.J.1 nonessential transcriptional regulatory protein KEEP 1899917..1900240 1899917 1900240 I NA NA IG1703_Rv1674c-Rv1675c KEEP 1900241..1900975 1900241 1900975 - 244 15608813 - Rv1675c COG0664T I.J.1 nonessential transcriptional regulatory protein KEEP 1900976..1901046 1900976 1901046 I NA NA IG1704_Rv1675c-Rv1676 KEEP 1901047..1901751 1901047 1901751 + 234 15608814 - Rv1676 COG0626E VI nonessential hypothetical protein KEEP 1901748..1902296 1901748 1902296 + 182 15608815 dsbF Rv1677 COG0526OC II.C.2 nonessential lipoprotein DsbF KEEP 1902297..1902396 1902297 1902396 I NA NA IG1706_Rv1677-Rv1678 KEEP 1902397..1903299 1902397 1903299 + 300 15608816 - Rv1678 - II.C.5 nonessential integral membrane protein KEEP 1903299..1904420 1903299 1904420 + 373 15608817 fadE16 Rv1679 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase KEEP 1904421..1904428 1904421 1904428 I NA NA IG1708_Rv1679-Rv1680 KEEP 1904429..1905253 1904429 1905253 + 274 15608818 - Rv1680 COG3221P VI nonessential hypothetical protein KEEP 1905250..1906242 1905250 1906242 + 330 15608819 moeX Rv1681 COG0535R I.G.4 nonessential molybdopterin biosynthesis protein MoeX KEEP 1906243..1906402 1906243 1906402 I NA NA IG1710_Rv1681-Rv1682 KEEP 1906403..1907320 1906403 1907320 + 305 15608820 - Rv1682 - VI nonessential coiled-coil structural protein KEEP 1907321..1907593 1907321 1907451 I NA NA IG1711_Rv1682-Rv1683 KEEP 1907321..1907593 1907452 1907583 I NA NA IG1711_Rv1682-Rv1683 Only Marin et al 2022 KEEP 1907321..1907593 1907584 1907593 I NA NA IG1711_Rv1682-Rv1683 KEEP 1907594..1910593 1907594 1910593 + 999 15608821 - Rv1683 COG0318IQ,COG3243I I.A.3 essential acyl-CoA synthetase KEEP 1910586..1910810 1910586 1910810 + 74 15608822 - Rv1684 COG2835S V nonessential hypothetical protein KEEP 1910776..1911399 1910776 1911399 - 207 15608823 - Rv1685c COG1309K V nonessential hypothetical protein KEEP 1911401..1912081 1911401 1912081 - 226 15608824 - Rv1686c COG0842V II.C.5 nonessential integral membrane protein ABC transporter KEEP 1912082..1912152 1912082 1912152 I NA NA IG1715_Rv1686c-Rv1687c KEEP 1912153..1912920 1912153 1912920 - 255 15608825 - Rv1687c COG1131V III.A nonessential ABC transporter ATP-binding protein KEEP 1912921..1912978 1912921 1912978 I NA NA IG1716_Rv1687c-Rv1688 KEEP 1912979..1913590 1912979 1913590 + 203 15608826 mpg Rv1688 COG2094L II.A.5 nonessential 3-methyladenine DNA glycosylase KEEP 1913591..1913601 1913591 1913601 I NA NA IG1717_Rv1688-Rv1689 KEEP 1913602..1914876 1913602 1914876 + 424 15608827 tyrS Rv1689 COG0162J II.A.3 essential tyrosyl-tRNA synthetase KEEP 1914877..1915526 1914877 1914969 I NA NA IG1718_Rv1689-Rv1690 KEEP 1914877..1915526 1914970 1914995 I NA NA IG1718_Rv1689-Rv1690 Only Marin et al 2022 KEEP 1914877..1915526 1914996 1914997 I NA NA IG1718_Rv1689-Rv1690 KEEP 1914877..1915526 1914998 1914999 I NA NA IG1718_Rv1689-Rv1690 Only Marin et al 2022 KEEP 1914877..1915526 1915000 1915526 I NA NA IG1718_Rv1689-Rv1690 KEEP 1915527..1915910 1915527 1915910 + 127 15608828 lprJ Rv1690 - II.C.1 nonessential lipoprotein LprJ KEEP 1915911..1915948 1915911 1915948 I NA NA IG1719_Rv1690-Rv1691 KEEP 1915949..1916701 1915949 1916701 + 250 15608829 - Rv1691 COG0457R V nonessential hypothetical protein KEEP 1916698..1917759 1916698 1917759 + 353 15608830 - Rv1692 COG0647G IV.I nonessential phosphatase KEEP 1917756..1917932 1917756 1917932 + 58 15608831 - Rv1693 - V nonessential hypothetical protein KEEP 1917933..1917939 1917933 1917939 I NA NA IG1722_Rv1693-Rv1694 KEEP 1917940..1918746 1917940 1918746 + 268 15608832 tlyA Rv1694 COG1189J IV.A DR-AMI nonessential cytotoxin/hemolysin TlyA KEEP 1918746..1919669 1918746 1919669 + 307 15608833 ppnK Rv1695 COG0061G VII essential inorganic polyphosphate/ATP-NAD kinase KEEP 1919670..1919682 1919670 1919682 I NA NA IG1724_Rv1695-Rv1696 KEEP 1919683..1921446 1919683 1921446 + 587 15608834 recN Rv1696 COG0497L II.A.5 essential DNA repair protein recN (recombination protein N) KEEP 1921447..1921541 1921447 1921541 I NA NA IG1725_Rv1696-Rv1697 KEEP 1921542..1922723 1921542 1922723 + 393 15608835 - Rv1697 COG4825S V essential hypothetical protein KEEP 1922724..1922744 1922724 1922744 I NA NA IG1726_Rv1697-Rv1698 KEEP 1922745..1923689 1922745 1923689 + 314 15608836 - Rv1698 - V nonessential hypothetical protein KEEP 1923690..1923828 1923690 1923828 I NA NA IG1727_Rv1698-Rv1699 KEEP 1923829..1925589 1923829 1925589 + 586 15608837 pyrG Rv1699 COG0504F I.F.2 essential CTP synthetase KEEP 1925582..1926205 1925582 1926205 + 207 15608838 - Rv1700 COG0494LR V nonessential hypothetical protein KEEP 1926202..1927137 1926202 1927137 + 311 15608839 xerD Rv1701 COG4974L IV.B.3 essential site-specific tyrosine recombinase XerD KEEP 1927138..1927210 1927138 1927210 I NA NA IG1730_Rv1701-Rv1702c KEEP 1927211..1928575 1927211 1928575 - 454 15608840 - Rv1702c COG0567C V nonessential hypothetical protein KEEP 1928576..1929130 1928576 1929130 I NA NA IG1731_Rv1702c-Rv1703c KEEP 1929131..1929721 1929131 1929721 - 196 15608841 - Rv1703c COG4122R IV.H nonessential catechol-o-methyltransferase KEEP 1929722..1929785 1929722 1929785 I NA NA IG1732_Rv1703c-Rv1704c KEEP 1929786..1931456 1929786 1931456 - 556 15608842 cycA Rv1704c COG1113E III.A.1 nonessential D-serine/alanine/glycine transporter protein CycA KEEP 1931457..1931496 1931457 1931496 I NA NA IG1733_Rv1704c-Rv1705c KEEP 1931497..1932654 1931497 1932654 - 385 57116898 PPE22 Rv1705c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 1932655..1932693 1932655 1932693 I NA NA IG1734_Rv1705c-Rv1706c repeat KEEP 1932694..1933878 1932694 1933296 - 394 57116899 PPE23 Rv1706c - V PE/PPE/PGRS nonessential PPE family protein KEEP 1932694..1933878 1933297 1933384 - 394 57116899 PPE23 Rv1706c - V PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1932694..1933878 1933385 1933711 - 394 57116899 PPE23 Rv1706c - V PE/PPE/PGRS nonessential PPE family protein KEEP 1932694..1933878 1933712 1933762 - 394 57116899 PPE23 Rv1706c - V PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 1932694..1933878 1933763 1933878 - 394 57116899 PPE23 Rv1706c - V PE/PPE/PGRS nonessential PPE family protein KEEP 1933879..1934481 1933879 1934481 I NA NA IG1735_Rv1706c-Rv1706A KEEP 1934482..1934649 1934482 1934649 - 55 57116900 - Rv1706A COG0477GEPR IV.C.1 nonessential hypothetical protein KEEP 1934650..1934881 1934650 1934881 I NA NA IG1736_Rv1706A-Rv1707 KEEP 1934882..1936342 1934882 1936342 + 486 15608845 - Rv1707 COG0659P III.A.4 nonessential transmembrane protein KEEP 1936343..1936359 1936343 1936359 I NA NA IG1737_Rv1707-Rv1708 KEEP 1936360..1937316 1936360 1937316 + 318 15608846 - Rv1708 COG1192D III.C essential putative initiation inhibitor protein KEEP 1937313..1938149 1937313 1938149 + 278 15608847 - Rv1709 COG1354S V nonessential hypothetical protein KEEP 1938146..1938841 1938146 1938841 + 231 15608848 - Rv1710 COG1386K V essential hypothetical protein KEEP 1938838..1939602 1938838 1939602 + 254 15608849 - Rv1711 COG1187J V essential hypothetical protein KEEP 1939599..1940291 1939599 1940291 + 230 15608850 cmk Rv1712 COG0283F I.F.5 essential cytidylate kinase KEEP 1940288..1941679 1940288 1941679 + 463 15608851 engA Rv1713 COG1160R VII essential GTP-binding protein EngA KEEP 1941680..1941852 1941680 1941852 I NA NA IG1743_Rv1713-Rv1714 KEEP 1941853..1942665 1941853 1942665 + 270 15608852 - Rv1714 COG1028IQR I.B.7 essential oxidoreductase KEEP 1942659..1943573 1942659 1943573 + 304 57116901 fadB3 Rv1715 COG1250I I.A.3 essential 3-hydroxybutyryl-CoA dehydrogenase FADB3 KEEP 1943574..1943575 1943574 1943575 I NA NA IG1745_Rv1715-Rv1716 KEEP 1943576..1944406 1943576 1944406 + 276 15608854 - Rv1716 COG1878R V nonessential hypothetical protein KEEP 1944406..1944756 1944406 1944756 + 116 15608855 - Rv1717 COG0662G,COG3837S V nonessential hypothetical protein KEEP 1944757..1944808 1944757 1944808 I NA NA IG1747_Rv1717-Rv1718 KEEP 1944809..1945627 1944809 1945627 + 272 15608856 - Rv1718 COG3246S V nonessential hypothetical protein KEEP 1945628..1945640 1945628 1945640 I NA NA IG1748_Rv1718-Rv1719 KEEP 1945641..1946420 1945641 1946420 + 259 15608857 - Rv1719 COG1414K I.J.1 nonessential transcriptional regulatory protein KEEP 1946421..1947029 1946421 1946845 I NA NA IG1749_Rv1719-Rv1720c KEEP 1946421..1947029 1946846 1947027 I NA NA IG1749_Rv1719-Rv1720c Only Marin et al 2022 KEEP 1946421..1947029 1947028 1947029 I NA NA IG1749_Rv1719-Rv1720c KEEP 1947030..1947419 1947030 1947419 - 129 15608858 - Rv1720c COG4113R V nonessential hypothetical protein KEEP 1947416..1947643 1947416 1947643 - 75 57116902 - Rv1721c - V nonessential hypothetical protein KEEP 1947644..1947860 1947644 1947860 I NA NA IG1751_Rv1721c-Rv1722 KEEP 1947861..1949345 1947861 1949345 + 494 15608860 - Rv1722 COG0439I I.H.1 nonessential biotin carboxylase-like protein KEEP 1949342..1950589 1949342 1950589 + 415 15608861 - Rv1723 COG1680V II.B.6 nonessential hydrolase KEEP 1950590..1950631 1950590 1950631 I NA NA IG1753_Rv1723-Rv1724c KEEP 1950632..1951051 1950632 1951051 - 139 15608862 - Rv1724c - VI nonessential hypothetical protein KEEP 1951041..1951751 1951041 1951751 - 236 15608863 - Rv1725c COG1733K V nonessential hypothetical protein KEEP 1951752..1951851 1951752 1951851 I NA NA IG1755_Rv1725c-Rv1726 KEEP 1951852..1953237 1951852 1953237 + 461 15608864 - Rv1726 COG0277C I.B.7 nonessential oxidoreductase KEEP 1953238..1953269 1953238 1953269 I NA NA IG1756_Rv1726-Rv1727 KEEP 1953270..1953839 1953270 1953839 + 189 15608865 - Rv1727 - V nonessential hypothetical protein KEEP 1953840..1953863 1953840 1953863 I NA NA IG1757_Rv1727-Rv1728c KEEP 1953864..1954634 1953864 1954634 - 256 15608866 - Rv1728c - V nonessential hypothetical protein KEEP 1954631..1955569 1954631 1955432 - 312 15608867 - Rv1729c COG3315Q V nonessential hypothetical protein KEEP 1954631..1955569 1955433 1955483 - 312 15608867 - Rv1729c COG3315Q V nonessential hypothetical protein Only Marin et al 2022 KEEP 1954631..1955569 1955484 1955569 - 312 15608867 - Rv1729c COG3315Q V nonessential hypothetical protein KEEP 1955570..1955691 1955570 1955580 I NA NA IG1759_Rv1729c-Rv1730c KEEP 1955570..1955691 1955581 1955615 I NA NA IG1759_Rv1729c-Rv1730c Only Marin et al 2022 KEEP 1955570..1955691 1955616 1955637 I NA NA IG1759_Rv1729c-Rv1730c KEEP 1955570..1955691 1955638 1955672 I NA NA IG1759_Rv1729c-Rv1730c Marin et al 2022 + homoplasy analysis DISCARD 1955570..1955691 1955673 1955691 I NA NA IG1759_Rv1729c-Rv1730c KEEP 1955692..1957245 1955692 1957245 - 517 15608868 - Rv1730c COG1680V II.C.3 essential penicillin-binding protein KEEP 1957246..1957676 1957246 1957676 I NA NA IG1760_Rv1730c-Rv1731 KEEP 1957677..1959233 1957677 1959233 + 518 57116903 gabD2 Rv1731 COG1012C I.A.1 nonessential succinic semialdehyde dehydrogenase KEEP 1959234..1959242 1959234 1959242 I NA NA IG1761_Rv1731-Rv1732c KEEP 1959243..1959791 1959243 1959791 - 182 15608870 - Rv1732c COG0526OC V nonessential hypothetical protein KEEP 1959792..1959854 1959792 1959854 I NA NA IG1762_Rv1732c-Rv1733c KEEP 1959855..1960487 1959855 1960487 - 210 15608871 - Rv1733c - II.C.5 nonessential transmembrane protein KEEP 1960488..1960773 1960488 1960773 I NA NA IG1763_Rv1733c-Rv1734c KEEP 1960774..1961016 1960774 1961016 - 80 15608872 - Rv1734c COG0508C V nonessential hypothetical protein KEEP 1961017..1961290 1961017 1961290 I NA NA IG1764_Rv1734c-Rv1735c KEEP 1961291..1961788 1961291 1961788 - 165 15608873 - Rv1735c COG1275P VI nonessential hypothetical protein KEEP 1961789..1962227 1961789 1962227 I NA NA IG1765_Rv1735c-Rv1736c KEEP 1962228..1964186 1962228 1963152 - 652 15608874 narX Rv1736c COG2180C,COG2181C,COG5013C I.B.6b nonessential nitrate reductase NarX KEEP 1962228..1964186 1963153 1963221 - 652 15608874 narX Rv1736c COG2180C,COG2181C,COG5013C I.B.6b nonessential nitrate reductase NarX Only Marin et al 2022 KEEP 1962228..1964186 1963222 1963419 - 652 15608874 narX Rv1736c COG2180C,COG2181C,COG5013C I.B.6b nonessential nitrate reductase NarX KEEP 1962228..1964186 1963420 1963705 - 652 15608874 narX Rv1736c COG2180C,COG2181C,COG5013C I.B.6b nonessential nitrate reductase NarX Only Marin et al 2022 KEEP 1962228..1964186 1963706 1963887 - 652 15608874 narX Rv1736c COG2180C,COG2181C,COG5013C I.B.6b nonessential nitrate reductase NarX KEEP 1962228..1964186 1963888 1963956 - 652 15608874 narX Rv1736c COG2180C,COG2181C,COG5013C I.B.6b nonessential nitrate reductase NarX Only Marin et al 2022 KEEP 1962228..1964186 1963957 1964186 - 652 15608874 narX Rv1736c COG2180C,COG2181C,COG5013C I.B.6b nonessential nitrate reductase NarX KEEP 1964183..1965370 1964183 1965370 - 395 15608875 narK2 Rv1737c COG2223P III.A.4 nonessential nitrate/nitrite transporter NarK2 KEEP 1965371..1965656 1965371 1965656 I NA NA IG1767_Rv1737c-Rv1738 KEEP 1965657..1965941 1965657 1965941 + 94 15608876 - Rv1738 - V essential hypothetical protein KEEP 1965942..1965954 1965942 1965954 I NA NA IG1768_Rv1738-Rv1739c KEEP 1965955..1967637 1965955 1967637 - 560 15608877 - Rv1739c COG0659P III.A.4 nonessential sulphate-transport transmembrane protein ABC transporter KEEP 1967638..1967704 1967638 1967704 I NA NA IG1769_Rv1739c-Rv1740 KEEP 1967705..1967917 1967705 1967879 + 70 15608878 - Rv1740 COG4423S V nonessential hypothetical protein KEEP 1967705..1967917 1967880 1967917 + 70 15608878 - Rv1740 COG4423S V nonessential hypothetical protein Only Marin et al 2022 KEEP 1967917..1968165 1967917 1967931 + 82 15608879 - Rv1741 COG3742S V nonessential hypothetical protein Only Marin et al 2022 KEEP 1967917..1968165 1967932 1968165 + 82 15608879 - Rv1741 COG3742S V nonessential hypothetical protein KEEP 1968166..1968172 1968166 1968172 I NA NA IG1771_Rv1741-Rv1742 KEEP 1968173..1968910 1968173 1968910 + 245 15608880 - Rv1742 - VI nonessential hypothetical protein KEEP 1968911..1969003 1968911 1969003 I NA NA IG1772_Rv1742-Rv1743 KEEP 1969004..1970704 1969004 1970704 + 566 15608881 pknE Rv1743 COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase E KEEP 1970705..1970988 1970705 1970988 I NA NA IG1773_Rv1743-Rv1744c KEEP 1970989..1971390 1970989 1971232 - 133 15608882 - Rv1744c - II.C.5 nonessential hypothetical protein KEEP 1970989..1971390 1971233 1971334 - 133 15608882 - Rv1744c - II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 1970989..1971390 1971335 1971390 - 133 15608882 - Rv1744c - II.C.5 nonessential hypothetical protein KEEP 1971380..1971991 1971380 1971991 - 203 15608883 idi Rv1745c COG1443I VII nonessential isopentenyl-diphosphate delta-isomerase KEEP 1971992..1972137 1971992 1972137 I NA NA IG1775_Rv1745c-Rv1746 KEEP 1972138..1973568 1972138 1973568 + 476 15608884 pknF Rv1746 COG0515RTKL I.J.3 nonessential anchored-membrane serine/threonine-protein kinase PKNF (protein kinase F) (STPK F) KEEP 1973569..1973629 1973569 1973629 I NA NA IG1776_Rv1746-Rv1747 KEEP 1973630..1976227 1973630 1976227 + 865 15608885 - Rv1747 COG1131V II.C.5 nonessential transmembrane ATP-binding protein ABC transporter KEEP 1976228..1976599 1976228 1976599 I NA NA IG1777_Rv1747-Rv1748 KEEP 1976600..1977331 1976600 1977331 + 243 15608886 - Rv1748 - VI nonessential hypothetical protein KEEP 1977328..1977885 1977328 1977885 - 185 15608887 - Rv1749c - II.C.5 nonessential integral membrane protein KEEP 1977886..1977968 1977886 1977968 I NA NA IG1779_Rv1749c-Rv1750c KEEP 1977969..1979567 1977969 1979567 - 532 15608888 fadD1 Rv1750c COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 1979568..1979620 1979568 1979620 I NA NA IG1780_Rv1750c-Rv1751 KEEP 1979621..1981003 1979621 1981003 + 460 15608889 - Rv1751 COG0654HC I.B.7 nonessential hypothetical protein KEEP 1981004..1981129 1981004 1981129 I NA NA IG1781_Rv1751-Rv1752 KEEP 1981130..1981579 1981130 1981579 + 149 15608890 - Rv1752 COG0673R V nonessential hypothetical protein KEEP 1981580..1981613 1981580 1981613 I NA NA IG1782_Rv1752-Rv1753c KEEP 1981614..1984775 1981614 1984775 - 1053 57116904 PPE24 Rv1753c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 1984776..1984978 1984776 1984978 I NA NA IG1783_Rv1753c-Rv1754c KEEP 1984979..1986670 1984979 1986670 - 563 15608892 - Rv1754c - V nonessential hypothetical protein KEEP 1986671..1986853 1986671 1986853 I NA NA IG1784_Rv1754c-Rv1755c KEEP 1986854..1987696 1986854 1987172 - 280 15608893 plcD Rv1755c COG3511M II.B.5 nonessential phospholipase C 4 PLCD KEEP 1986854..1987696 1987173 1987241 - 280 15608893 plcD Rv1755c COG3511M II.B.5 nonessential phospholipase C 4 PLCD Only Marin et al 2022 KEEP 1986854..1987696 1987242 1987343 - 280 15608893 plcD Rv1755c COG3511M II.B.5 nonessential phospholipase C 4 PLCD KEEP 1986854..1987696 1987344 1987406 - 280 15608893 plcD Rv1755c COG3511M II.B.5 nonessential phospholipase C 4 PLCD Only Marin et al 2022 KEEP 1986854..1987696 1987407 1987692 - 280 15608893 plcD Rv1755c COG3511M II.B.5 nonessential phospholipase C 4 PLCD KEEP 1986854..1987696 1987693 1987696 - 280 15608893 plcD Rv1755c COG3511M II.B.5 nonessential phospholipase C 4 PLCD Only Marin et al 2022 KEEP 1987697..1987744 1987697 1987744 I NA NA IG1785_Rv1755c-Rv1756c Annotation + Marin et al 2022 DISCARD 1987745..1988629 1987745 1988629 - 294 15608894 - Rv1756c COG2801L IV.B.1 phage nonessential putative transposase Annotation + Marin et al 2022 DISCARD 1988630..1988679 1988630 1988679 I NA NA IG1786_Rv1756c-Rv1757c repeat Annotation + Marin et al 2022 DISCARD 1988680..1989006 1988680 1989006 - 108 15608895 - Rv1757c COG2963L IV.B.1 phage nonessential putative transposase Annotation + Marin et al 2022 DISCARD 1989007..1989041 1989007 1989041 I NA NA IG1787_Rv1757c-Rv1758 Annotation + Marin et al 2022 DISCARD 1989042..1989566 1989042 1989068 + 174 15608896 cut1 Rv1758 - II.C.2 nonessential cutinase Cut1 Marin et al 2022 + homoplasy analysis DISCARD 1989042..1989566 1989069 1989566 + 174 15608896 cut1 Rv1758 - II.C.2 nonessential cutinase Cut1 KEEP 1989567..1989832 1989567 1989832 I NA NA IG1788_Rv1758-Rv1759c KEEP 1989833..1992577 1989833 1989893 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1989833..1992577 1989894 1989972 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1989833..1992577 1989973 1989981 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1989833..1992577 1989982 1990093 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1989833..1992577 1990094 1990108 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1989833..1992577 1990109 1990114 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1989833..1992577 1990115 1990321 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1989833..1992577 1990322 1990823 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1989833..1992577 1990824 1991180 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1989833..1992577 1991181 1991480 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1989833..1992577 1991481 1991568 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1989833..1992577 1991569 1992029 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1989833..1992577 1992030 1992053 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1989833..1992577 1992054 1992111 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1989833..1992577 1992112 1992281 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1989833..1992577 1992282 1992334 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 1989833..1992577 1992335 1992577 - 914 57116905 wag22 Rv1759c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 1992578..1993152 1992578 1993152 I NA NA IG1789_Rv1759c-Rv1760 KEEP 1993153..1994661 1993153 1994661 + 502 15608898 - Rv1760 - V nonessential hypothetical protein KEEP 1994662..1994670 1994662 1994670 I NA NA IG1790_Rv1760-Rv1761c KEEP 1994671..1995054 1994671 1995054 - 127 15608899 - Rv1761c - VI nonessential hypothetical protein KEEP 1995054..1995842 1995054 1995842 - 262 15608900 - Rv1762c COG0393S VI nonessential hypothetical protein KEEP 1995843..1996151 1995843 1996091 I NA NA IG1792_Rv1762c-Rv1763 KEEP 1995843..1996151 1996092 1996151 I NA NA IG1792_Rv1762c-Rv1763 Annotation + Marin et al 2022 DISCARD 1996152..1996478 1996152 1996478 + 108 15608901 - Rv1763 COG2963L IV.B.1 phage nonessential putative transposase Annotation + Marin et al 2022 DISCARD 1996479..1996528 1996479 1996528 I NA NA IG1793_Rv1763-Rv1764 repeat Annotation + Marin et al 2022 DISCARD 1996529..1997413 1996529 1997413 + 294 15608902 - Rv1764 COG2801L IV.B.1 phage nonessential putative transposase Annotation + Marin et al 2022 DISCARD 1997414..1997417 1997414 1997417 I NA NA IG1794_Rv1764-Rv1765c Annotation + Marin et al 2022 DISCARD 1997418..1998515 1997418 1998515 - 365 15608903 - Rv1765c COG0583K IV.B.1 nonessential hypothetical protein Only Marin et al 2022 KEEP 1998516..1999141 1998516 1998618 I NA NA IG1795_Rv1765c-Rv1765A Annotation + Marin et al 2022 DISCARD 1998516..1999141 1998619 1999141 I NA NA IG1795_Rv1765c-Rv1765A KEEP 1999142..1999357 1999142 1999357 - 71 57116906 - Rv1765A COG2801L V phage nonessential transposase KEEP 1999358..1999736 1999358 1999736 I NA NA IG1796_Rv1765A-Rv1766 KEEP 1999737..2000006 1999737 2000006 + 89 57116907 - Rv1766 COG1937S V nonessential hypothetical protein KEEP 2000007..2000073 2000007 2000073 I NA NA IG1797_Rv1766-Rv1767 KEEP 2000074..2000433 2000074 2000433 + 119 15608905 - Rv1767 COG0599S V nonessential hypothetical protein KEEP 2000434..2000613 2000434 2000613 I NA NA IG1798_Rv1767-Rv1768 KEEP 2000614..2002470 2000614 2000923 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2000614..2002470 2000924 2000998 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2000614..2002470 2000999 2001008 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2000614..2002470 2001009 2001062 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2000614..2002470 2001063 2001204 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2000614..2002470 2001205 2001716 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2000614..2002470 2001717 2002028 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2000614..2002470 2002029 2002036 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2000614..2002470 2002037 2002124 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2000614..2002470 2002125 2002328 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2000614..2002470 2002329 2002404 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2000614..2002470 2002405 2002406 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2000614..2002470 2002407 2002470 + 618 57116908 PE_PGRS31 Rv1768 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2002471..2002625 2002471 2002625 I NA NA IG1799_Rv1768-Rv1769 KEEP 2002626..2003870 2002626 2003870 + 414 15608907 - Rv1769 COG3616E V nonessential hypothetical protein KEEP 2003871..2003877 2003871 2003877 I NA NA IG1800_Rv1769-Rv1770 KEEP 2003878..2005164 2003878 2005164 + 428 15608908 - Rv1770 COG2234R V nonessential hypothetical protein KEEP 2005161..2006447 2005161 2006447 + 428 15608909 - Rv1771 COG0277C I.B.7 nonessential oxidoreductase KEEP 2006448..2006635 2006448 2006635 I NA NA IG1802_Rv1771-Rv1772 KEEP 2006636..2006947 2006636 2006947 + 103 15608910 - Rv1772 COG3707T VI DR-inh nonessential hypothetical protein KEEP 2006948..2007019 2006948 2007019 I NA NA IG1803_Rv1772-Rv1773c KEEP 2007020..2007766 2007020 2007766 - 248 15608911 - Rv1773c COG1414K I.J.1 nonessential transcriptional regulatory protein KEEP 2007767..2007831 2007767 2007831 I NA NA IG1804_Rv1773c-Rv1774 KEEP 2007832..2009172 2007832 2009172 + 446 15608912 - Rv1774 COG0277C I.B.7 nonessential oxidoreductase KEEP 2009172..2009990 2009172 2009990 + 272 15608913 - Rv1775 - V nonessential hypothetical protein KEEP 2009991..2009994 2009991 2009994 I NA NA IG1806_Rv1775-Rv1776c KEEP 2009995..2010555 2009995 2010555 - 186 15608914 - Rv1776c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 2010556..2010655 2010556 2010655 I NA NA IG1807_Rv1776c-Rv1777 KEEP 2010656..2011960 2010656 2011960 + 434 15608915 cyp144 Rv1777 COG2124Q IV.F nonessential cytochrome p450 144 CYP144 KEEP 2011961..2012080 2011961 2012080 I NA NA IG1808_Rv1777-Rv1778c KEEP 2012081..2012530 2012081 2012530 - 149 15608916 - Rv1778c - VI nonessential hypothetical protein KEEP 2012531..2012685 2012531 2012685 I NA NA IG1809_Rv1778c-Rv1779c KEEP 2012686..2014479 2012686 2014479 - 597 15608917 - Rv1779c - VI nonessential integral membrane protein KEEP 2014480..2014698 2014480 2014698 I NA NA IG1810_Rv1779c-Rv1780 KEEP 2014699..2015262 2014699 2015262 + 187 15608918 - Rv1780 - V nonessential hypothetical protein KEEP 2015263..2015301 2015263 2015301 I NA NA IG1811_Rv1780-Rv1781c KEEP 2015302..2017476 2015302 2017476 - 724 15608919 malQ Rv1781c COG1640G II.A.8 nonessential 4-alpha-glucanotransferase MalQ KEEP 2017477..2017739 2017477 2017739 I NA NA IG1812_Rv1781c-Rv1782 KEEP 2017740..2019260 2017740 2019260 + 506 15608920 - Rv1782 - II.C.4 nonessential hypothetical protein KEEP 2019257..2020564 2019257 2020564 + 435 15608921 - Rv1783 COG1674D II.C.4 nonessential hypothetical protein KEEP 2020565..2020633 2020565 2020633 I NA NA IG1814_Rv1783-Rv1784 KEEP 2020634..2023432 2020634 2023432 + 932 15608922 - Rv1784 COG1674D V nonessential hypothetical protein KEEP 2023433..2023446 2023433 2023446 I NA NA IG1815_Rv1784-Rv1785c KEEP 2023447..2024628 2023447 2024628 - 393 15608923 cyp143 Rv1785c COG2124Q IV.F nonessential cytochrome P450 143 KEEP 2024629..2024827 2024629 2024827 I NA NA IG1816_Rv1785c-Rv1786 KEEP 2024828..2025031 2024828 2025031 + 67 15608924 - Rv1786 COG1141C VII nonessential ferredoxin KEEP 2025032..2025300 2025032 2025295 I NA NA IG1817_Rv1786-Rv1787 KEEP 2025032..2025300 2025296 2025300 I NA NA IG1817_Rv1786-Rv1787 Annotation + Marin et al 2022 DISCARD 2025301..2026398 2025301 2025858 + 365 57116909 PPE25 Rv1787 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2025301..2026398 2025859 2025890 + 365 57116909 PPE25 Rv1787 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2025301..2026398 2025891 2026167 + 365 57116909 PPE25 Rv1787 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2025301..2026398 2026168 2026398 + 365 57116909 PPE25 Rv1787 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2026399..2026476 2026399 2026476 I NA NA IG1818_Rv1787-Rv1788 repeat KEEP 2026477..2026776 2026477 2026776 + 99 57116910 PE18 Rv1788 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 2026777..2026789 2026777 2026789 I NA NA IG1819_Rv1788-Rv1789 repeat KEEP 2026790..2027971 2026790 2027971 + 393 57116911 PPE26 Rv1789 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2027972..2028424 2027972 2028419 I NA NA IG1820_Rv1789-Rv1790 repeat KEEP 2027972..2028424 2028420 2028424 I NA NA IG1820_Rv1789-Rv1790 repeat Annotation + Marin et al 2022 DISCARD 2028425..2029477 2028425 2029246 + 350 57116912 PPE27 Rv1790 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2028425..2029477 2029247 2029477 + 350 57116912 PPE27 Rv1790 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2029478..2029903 2029478 2029903 I NA NA IG1821_Rv1790-Rv1791 repeat KEEP 2029904..2030203 2029904 2030203 + 99 57116913 PE19 Rv1791 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 2030204..2030693 2030204 2030327 I NA NA IG1822_Rv1791-Rv1793 KEEP 2030204..2030693 2030328 2030648 I NA NA IG1822_Rv1791-Rv1793 Annotation + Marin et al 2022 DISCARD 2030204..2030693 2030649 2030693 I NA NA IG1822_Rv1791-Rv1793 KEEP 2030694..2030978 2030694 2030702 + 94 57116914 esxN Rv1793 - VI nonessential putative ESAT-6 like protein ESXN (ESAT-6 like protein 5) KEEP 2030694..2030978 2030703 2030978 + 94 57116914 esxN Rv1793 - VI nonessential putative ESAT-6 like protein ESXN (ESAT-6 like protein 5) Marin et al 2022 + homoplasy analysis DISCARD 2030979..2031065 2030979 2030986 I NA NA IG1823_Rv1793-Rv1794 Only Marin et al 2022 KEEP 2030979..2031065 2030987 2031065 I NA NA IG1823_Rv1793-Rv1794 KEEP 2031066..2031968 2031066 2031968 + 300 15608931 - Rv1794 - V nonessential hypothetical protein KEEP 2031969..2032239 2031969 2032239 I NA NA IG1824_Rv1794-Rv1795 KEEP 2032240..2033751 2032240 2033751 + 503 15608932 - Rv1795 - V nonessential hypothetical protein KEEP 2033729..2035486 2033729 2035486 + 585 15608933 mycP5 Rv1796 COG1404O II.C.5 nonessential proline rich membrane-anchored mycosin MYCP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) KEEP 2035483..2036703 2035483 2036703 + 406 15608934 - Rv1797 - V nonessential hypothetical protein KEEP 2036700..2038532 2036700 2038532 + 610 15608935 - Rv1798 COG0464O V nonessential hypothetical protein KEEP 2038533..2039158 2038533 2039158 I NA NA IG1828_Rv1798-Rv1799 KEEP 2039159..2039350 2039159 2039350 + 63 15608936 lppT Rv1799 - II.C.1 nonessential lipoprotein LppT KEEP 2039351..2039452 2039351 2039452 I NA NA IG1829_Rv1799-Rv1800 KEEP 2039453..2041420 2039453 2039730 + 655 57116915 PPE28 Rv1800 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2039453..2041420 2039731 2039781 + 655 57116915 PPE28 Rv1800 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2039453..2041420 2039782 2041420 + 655 57116915 PPE28 Rv1800 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2041421..2042000 2041421 2042000 I NA NA IG1830_Rv1800-Rv1801 repeat KEEP 2042001..2043272 2042001 2043272 + 423 57116916 PPE29 Rv1801 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2043273..2043383 2043273 2043383 I NA NA IG1831_Rv1801-Rv1802 repeat KEEP 2043384..2044775 2043384 2043796 + 463 57116917 PPE30 Rv1802 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2043384..2044775 2043797 2043858 + 463 57116917 PPE30 Rv1802 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2043384..2044775 2043859 2044775 + 463 57116917 PPE30 Rv1802 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2044776..2044922 2044776 2044922 I NA NA IG1832_Rv1802-Rv1803c repeat KEEP 2044923..2046842 2044923 2045047 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + homoplasy analysis DISCARD 2044923..2046842 2045048 2045107 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2044923..2046842 2045108 2045962 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2044923..2046842 2045963 2045964 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2044923..2046842 2045965 2045968 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2044923..2046842 2045969 2045970 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2044923..2046842 2045971 2046099 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2044923..2046842 2046100 2046195 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2044923..2046842 2046196 2046842 - 639 57116918 PE_PGRS32 Rv1803c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2046843..2047022 2046843 2047022 I NA NA IG1833_Rv1803c-Rv1804c KEEP 2047023..2047349 2047023 2047349 - 108 15608941 - Rv1804c - V nonessential hypothetical protein KEEP 2047350..2047686 2047350 2047626 I NA NA IG1834_Rv1804c-Rv1805c KEEP 2047350..2047686 2047627 2047686 I NA NA IG1834_Rv1804c-Rv1805c Only Marin et al 2022 KEEP 2047687..2048034 2047687 2047721 - 115 15608942 - Rv1805c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 2047687..2048034 2047722 2048034 - 115 15608942 - Rv1805c - VI nonessential hypothetical protein KEEP 2048035..2048071 2048035 2048071 I NA NA IG1835_Rv1805c-Rv1806 KEEP 2048072..2048371 2048072 2048371 + 99 57116919 PE20 Rv1806 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 2048372..2048397 2048372 2048397 I NA NA IG1836_Rv1806-Rv1807 repeat KEEP 2048398..2049597 2048398 2048788 + 399 57116920 PPE31 Rv1807 - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 2048398..2049597 2048789 2048842 + 399 57116920 PPE31 Rv1807 - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 2048398..2049597 2048843 2049597 + 399 57116920 PPE31 Rv1807 - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 2049598..2049920 2049598 2049920 I NA NA IG1837_Rv1807-Rv1808 repeat KEEP 2049921..2051150 2049921 2050286 + 409 57116921 PPE32 Rv1808 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2049921..2051150 2050287 2050398 + 409 57116921 PPE32 Rv1808 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2049921..2051150 2050399 2051150 + 409 57116921 PPE32 Rv1808 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2051151..2051281 2051151 2051281 I NA NA IG1838_Rv1808-Rv1809 repeat KEEP 2051282..2052688 2051282 2052688 + 468 57116922 PPE33 Rv1809 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2052689..2052932 2052689 2052932 I NA NA IG1839_Rv1809-Rv1810 KEEP 2052933..2053289 2052933 2053289 + 118 15608947 - Rv1810 - V nonessential hypothetical protein KEEP 2053290..2053442 2053290 2053442 I NA NA IG1840_Rv1810-Rv1811 KEEP 2053443..2054147 2053443 2054147 + 234 15608948 mgtC Rv1811 COG1285S III.A.2 nonessential Mg2+ transport P-type ATPase C KEEP 2054148..2054156 2054148 2054156 I NA NA IG1841_Rv1811-Rv1812c KEEP 2054157..2055359 2054157 2055359 - 400 15608949 - Rv1812c COG1252C VI nonessential dehydrogenase KEEP 2055360..2055680 2055360 2055680 I NA NA IG1842_Rv1812c-Rv1813c KEEP 2055681..2056112 2055681 2056112 - 143 15608950 - Rv1813c - V nonessential hypothetical protein KEEP 2056113..2056520 2056113 2056520 I NA NA IG1843_Rv1813c-Rv1814 KEEP 2056521..2057423 2056521 2057423 + 300 15608951 erg3 Rv1814 COG3000I I.H.3 nonessential membrane-bound C-5 sterol desaturase erg3 (sterol-c5-desaturase) KEEP 2057424..2057527 2057424 2057527 I NA NA IG1844_Rv1814-Rv1815 KEEP 2057528..2058193 2057528 2058193 + 221 15608952 - Rv1815 - V nonessential hypothetical protein KEEP 2058194..2058255 2058194 2058255 I NA NA IG1845_Rv1815-Rv1816 KEEP 2058256..2058960 2058256 2058960 + 234 15608953 - Rv1816 COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 2058961..2059594 2058961 2059424 I NA NA IG1846_Rv1816-Rv1817 KEEP 2058961..2059594 2059425 2059594 I NA NA IG1846_Rv1816-Rv1817 Only Marin et al 2022 KEEP 2059595..2061058 2059595 2059608 + 487 15608954 - Rv1817 COG1053C VI nonessential hypothetical protein Only Marin et al 2022 KEEP 2059595..2061058 2059609 2061058 + 487 15608954 - Rv1817 COG1053C VI nonessential hypothetical protein KEEP 2061059..2061177 2061059 2061177 I NA NA IG1847_Rv1817-Rv1818c KEEP 2061178..2062674 2061178 2061411 - 498 57116923 PE_PGRS33 Rv1818c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2061178..2062674 2061412 2062159 - 498 57116923 PE_PGRS33 Rv1818c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2061178..2062674 2062160 2062285 - 498 57116923 PE_PGRS33 Rv1818c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2061178..2062674 2062286 2062369 - 498 57116923 PE_PGRS33 Rv1818c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2061178..2062674 2062370 2062447 - 498 57116923 PE_PGRS33 Rv1818c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2061178..2062674 2062448 2062515 - 498 57116923 PE_PGRS33 Rv1818c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2061178..2062674 2062516 2062674 - 498 57116923 PE_PGRS33 Rv1818c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2062675..2062808 2062675 2062808 I NA NA IG1848_Rv1818c-Rv1819c KEEP 2062809..2064728 2062809 2064728 - 639 15608956 - Rv1819c COG4178R III.A.6 nonessential drugs-transport transmembrane ATP-binding protein ABC transporter KEEP 2064729..2064798 2064729 2064798 I NA NA IG1849_Rv1819c-Rv1820 KEEP 2064799..2066442 2064799 2066442 + 547 15608957 ilvG Rv1820 COG0028EH I.D.7 nonessential hypothetical protein KEEP 2066443..2066456 2066443 2066456 I NA NA IG1850_Rv1820-Rv1821 KEEP 2066457..2068883 2066457 2068883 + 808 15608958 secA2 Rv1821 COG0653U III.D essential preprotein translocase subunit SecA KEEP 2068884..2069079 2068884 2069015 I NA NA IG1851_Rv1821-Rv1822 KEEP 2068884..2069079 2069016 2069069 I NA NA IG1851_Rv1821-Rv1822 Only Marin et al 2022 KEEP 2068884..2069079 2069070 2069079 I NA NA IG1851_Rv1821-Rv1822 KEEP 2069080..2069709 2069080 2069709 + 209 15608959 pgsA2 Rv1822 COG0558I I.H.3 nonessential CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase KEEP 2069702..2070625 2069702 2070625 + 307 15608960 - Rv1823 COG3879S V nonessential hypothetical protein KEEP 2070626..2070653 2070626 2070653 I NA NA IG1853_Rv1823-Rv1824 KEEP 2070654..2071019 2070654 2071019 + 121 15608961 - Rv1824 COG3856S V nonessential hypothetical protein KEEP 2071020..2071035 2071020 2071035 I NA NA IG1854_Rv1824-Rv1825 KEEP 2071036..2071914 2071036 2071914 + 292 15608962 - Rv1825 COG3879S V nonessential hypothetical protein KEEP 2071915..2071951 2071915 2071951 I NA NA IG1855_Rv1825-Rv1826 KEEP 2071952..2072356 2071952 2072356 + 134 15608963 gcvH Rv1826 COG0509E I.C.1 nonessential glycine cleavage system protein H KEEP 2072357..2072595 2072357 2072595 I NA NA IG1856_Rv1826-Rv1827 KEEP 2072596..2073084 2072596 2073084 + 162 15608964 cfp17 Rv1827 COG1716T V nonessential hypothetical protein KEEP 2073081..2073824 2073081 2073824 + 247 15608965 - Rv1828 COG0789K V essential hypothetical protein KEEP 2073825..2073942 2073825 2073942 I NA NA IG1858_Rv1828-Rv1829 KEEP 2073943..2074437 2073943 2074429 + 164 15608966 - Rv1829 COG1259S V nonessential hypothetical protein KEEP 2073943..2074437 2074430 2074437 + 164 15608966 - Rv1829 COG1259S V nonessential hypothetical protein Only Marin et al 2022 KEEP 2074438..2074840 2074438 2074840 I NA NA IG1859_Rv1829-Rv1830 Only Marin et al 2022 KEEP 2074841..2075518 2074841 2075518 + 225 15608967 - Rv1830 COG0789K V nonessential hypothetical protein KEEP 2075519..2075570 2075519 2075570 I NA NA IG1860_Rv1830-Rv1831 KEEP 2075571..2075828 2075571 2075828 + 85 15608968 - Rv1831 - VI nonessential hypothetical protein KEEP 2075829..2075876 2075829 2075876 I NA NA IG1861_Rv1831-Rv1832 KEEP 2075877..2078702 2075877 2078702 + 941 15608969 gcvB Rv1832 COG0403E,COG1003E I.C.1 essential glycine dehydrogenase KEEP 2078703..2078928 2078703 2078928 I NA NA IG1862_Rv1832-Rv1833c KEEP 2078929..2079789 2078929 2079789 - 286 15608970 - Rv1833c COG0596R VII nonessential haloalkane dehalogenase KEEP 2079790..2079829 2079790 2079829 I NA NA IG1863_Rv1833c-Rv1834 KEEP 2079830..2080696 2079830 2080696 + 288 15608971 - Rv1834 COG0596R IV.I nonessential hydrolase KEEP 2080697..2080700 2080697 2080700 I NA NA IG1864_Rv1834-Rv1835c KEEP 2080701..2082587 2080701 2082587 - 628 15608972 - Rv1835c COG2936R V nonessential hypothetical protein KEEP 2082588..2082602 2082588 2082602 I NA NA IG1865_Rv1835c-Rv1836c KEEP 2082603..2084636 2082603 2084636 - 677 15608973 - Rv1836c - V nonessential hypothetical protein KEEP 2084637..2084755 2084637 2084755 I NA NA IG1866_Rv1836c-Rv1837c KEEP 2084756..2086981 2084756 2086981 - 741 15608974 glcB Rv1837c COG2225C I.B.4 nonessential malate synthase G KEEP 2086982..2087256 2086982 2087256 I NA NA IG1867_Rv1837c-Rv1838c KEEP 2087257..2087652 2087257 2087652 - 131 15608975 - Rv1838c COG1848R V nonessential hypothetical protein KEEP 2087649..2087912 2087649 2087912 - 87 15608976 - Rv1839c - V nonessential hypothetical protein KEEP 2087913..2087970 2087913 2087970 I NA NA IG1869_Rv1839c-Rv1840c Annotation + homoplasy analysis DISCARD 2087971..2089518 2087971 2088460 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2087971..2089518 2088461 2088499 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2087971..2089518 2088500 2088772 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2087971..2089518 2088773 2088933 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2087971..2089518 2088934 2088945 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2087971..2089518 2088946 2088949 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2087971..2089518 2088950 2089091 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2087971..2089518 2089092 2089162 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2087971..2089518 2089163 2089291 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2087971..2089518 2089292 2089348 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2087971..2089518 2089349 2089518 - 515 57116924 PE_PGRS34 Rv1840c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2089519..2089680 2089519 2089680 I NA NA IG1870_Rv1840c-Rv1841c KEEP 2089681..2090718 2089681 2090718 - 345 15608978 - Rv1841c COG1253R V nonessential hypothetical protein KEEP 2090718..2092085 2090718 2092085 - 455 15608979 - Rv1842c COG1253R V nonessential hypothetical protein KEEP 2092086..2092258 2092086 2092258 I NA NA IG1872_Rv1842c-Rv1843c KEEP 2092259..2093698 2092259 2093698 - 479 15608980 guaB1 Rv1843c COG0516F,COG0517R I.F.1 nonessential inositol-5-monophosphate dehydrogenase KEEP 2093699..2093730 2093699 2093730 I NA NA IG1873_Rv1843c-Rv1844c KEEP 2093731..2095188 2093731 2095188 - 485 57116925 gnd1 Rv1844c COG0362G I.B.5 nonessential 6-phosphogluconate dehydrogenase KEEP 2095189..2095217 2095189 2095217 I NA NA IG1874_Rv1844c-Rv1845c KEEP 2095218..2096168 2095218 2096168 - 316 15608982 - Rv1845c COG0501O V nonessential hypothetical protein KEEP 2096169..2096182 2096169 2096182 I NA NA IG1875_Rv1845c-Rv1846c KEEP 2096183..2096599 2096183 2096599 - 138 15608983 - Rv1846c COG3682K I.J.1 nonessential transcriptional regulatory protein KEEP 2096600..2096876 2096600 2096824 I NA NA IG1876_Rv1846c-Rv1847 KEEP 2096600..2096876 2096825 2096840 I NA NA IG1876_Rv1846c-Rv1847 Only Marin et al 2022 KEEP 2096600..2096876 2096841 2096842 I NA NA IG1876_Rv1846c-Rv1847 KEEP 2096600..2096876 2096843 2096849 I NA NA IG1876_Rv1846c-Rv1847 Only Marin et al 2022 KEEP 2096600..2096876 2096850 2096876 I NA NA IG1876_Rv1846c-Rv1847 KEEP 2096877..2097299 2096877 2097299 + 140 15608984 - Rv1847 COG2050Q V nonessential hypothetical protein KEEP 2097300..2097347 2097300 2097347 I NA NA IG1877_Rv1847-Rv1848 KEEP 2097348..2097650 2097348 2097650 + 100 15608985 ureA Rv1848 COG0831E I.A.2 nonessential urease subunit gamma KEEP 2097647..2097961 2097647 2097961 + 104 15608986 ureB Rv1849 COG0832E I.A.2 nonessential urease subunit beta KEEP 2097961..2099694 2097961 2099694 + 577 15608987 ureC Rv1850 COG0804E I.A.2 essential urease subunit alpha KEEP 2099694..2100329 2099694 2100329 + 211 15608988 ureF Rv1851 COG0830O I.A.2 nonessential urease accessory protein uref KEEP 2100330..2100339 2100330 2100339 I NA NA IG1881_Rv1851-Rv1852 KEEP 2100340..2101014 2100340 2101014 + 224 15608989 ureG Rv1852 COG0378OK I.A.2 nonessential urease accessory protein ureG KEEP 2101015..2101021 2101015 2101021 I NA NA IG1882_Rv1852-Rv1853 KEEP 2101022..2101648 2101022 2101648 + 208 15608990 ureD Rv1853 - I.A.2 nonessential urease accessory protein ureD KEEP 2101649..2101650 2101649 2101650 I NA NA IG1883_Rv1853-Rv1854c KEEP 2101651..2103042 2101651 2102845 - 463 15608991 ndh Rv1854c COG1252C I.B.6a DR-inh nonessential NADH dehydrogenase KEEP 2101651..2103042 2102846 2102899 - 463 15608991 ndh Rv1854c COG1252C I.B.6a DR-inh nonessential NADH dehydrogenase Only Marin et al 2022 KEEP 2101651..2103042 2102900 2103042 - 463 15608991 ndh Rv1854c COG1252C I.B.6a DR-inh nonessential NADH dehydrogenase KEEP 2103043..2103183 2103043 2103183 I NA NA IG1884_Rv1854c-Rv1855c KEEP 2103184..2104107 2103184 2104107 - 307 15608992 - Rv1855c COG2141C I.B.7 nonessential oxidoreductase KEEP 2104108..2104145 2104108 2104145 I NA NA IG1885_Rv1855c-Rv1856c KEEP 2104146..2104823 2104146 2104823 - 225 15608993 - Rv1856c COG1028IQR I.B.7 nonessential short chain dehydrogenase KEEP 2104824..2104984 2104824 2104984 I NA NA IG1886_Rv1856c-Rv1857 KEEP 2104985..2105770 2104985 2105770 + 261 15608994 modA Rv1857 COG0725P III.A.4 nonessential molybdate-binding lipoprotein KEEP 2105771..2105772 2105771 2105772 I NA NA IG1887_Rv1857-Rv1858 KEEP 2105773..2106567 2105773 2106567 + 264 15608995 modB Rv1858 COG4149P III.A.4 nonessential molbdenum-transport integral membrane protein ABC transporter KEEP 2106568..2106573 2106568 2106573 I NA NA IG1888_Rv1858-Rv1859 KEEP 2106574..2107683 2106574 2107683 + 369 15608996 modC Rv1859 COG1118P,COG3839G III.A.4 nonessential molybdenum ABC transporter ATP-binding protein KEEP 2107684..2107735 2107684 2107735 I NA NA IG1889_Rv1859-Rv1860 KEEP 2107736..2108713 2107736 2108713 + 325 57116926 apa Rv1860 - III.A.4 nonessential hypothetical protein KEEP 2108714..2109164 2108714 2109164 I NA NA IG1890_Rv1860-Rv1861 KEEP 2109165..2109470 2109165 2109470 + 101 15608998 - Rv1861 COG2261S II.C.5 nonessential transmembrane protein KEEP 2109471..2109543 2109471 2109543 I NA NA IG1891_Rv1861-Rv1862 KEEP 2109544..2110584 2109544 2110584 + 346 15608999 adhA Rv1862 COG1064R I.B.7 nonessential alcohol dehydrogenase AdhA KEEP 2110585..2110590 2110585 2110590 I NA NA IG1892_Rv1862-Rv1863c KEEP 2110591..2111361 2110591 2111361 - 256 15609000 - Rv1863c COG1266R II.C.5 nonessential integral membrane protein KEEP 2111354..2112109 2111354 2112109 - 251 15609001 - Rv1864c COG2258S V nonessential hypothetical protein KEEP 2112106..2112966 2112106 2112966 - 286 15609002 - Rv1865c COG1028IQR VI nonessential short chain dehydrogenase KEEP 2112967..2113139 2112967 2113139 I NA NA IG1895_Rv1865c-Rv1866 KEEP 2113140..2115476 2113140 2115476 + 778 15609003 - Rv1866 COG1804C V nonessential hypothetical protein KEEP 2115477..2115763 2115477 2115707 I NA NA IG1896_Rv1866-Rv1867 KEEP 2115477..2115763 2115708 2115758 I NA NA IG1896_Rv1866-Rv1867 Only Marin et al 2022 KEEP 2115477..2115763 2115759 2115763 I NA NA IG1896_Rv1866-Rv1867 KEEP 2115764..2117248 2115764 2117248 + 494 15609004 - Rv1867 COG0183I I.H.3 nonessential acetyl-CoA acetyltransferase KEEP 2117249..2117346 2117249 2117346 I NA NA IG1897_Rv1867-Rv1868 KEEP 2117347..2119446 2117347 2119446 + 699 15609005 - Rv1868 COG0451MG V nonessential hypothetical protein KEEP 2119447..2119459 2119447 2119459 I NA NA IG1898_Rv1868-Rv1869c KEEP 2119460..2120695 2119460 2120695 - 411 15609006 - Rv1869c COG0446R VI nonessential reductase KEEP 2120696..2120794 2120696 2120794 I NA NA IG1899_Rv1869c-Rv1870c KEEP 2120795..2121430 2120795 2121430 - 211 15609007 - Rv1870c - V nonessential hypothetical protein KEEP 2121431..2121494 2121431 2121494 I NA NA IG1900_Rv1870c-Rv1871c KEEP 2121495..2121884 2121495 2121884 - 129 15609008 - Rv1871c - V nonessential hypothetical protein KEEP 2121885..2121906 2121885 2121906 I NA NA IG1901_Rv1871c-Rv1872c KEEP 2121907..2123151 2121907 2123151 - 414 15609009 lldD2 Rv1872c COG1304C I.B.6a nonessential L-lactate dehydrogenase (cytochrome) LldD2 KEEP 2123152..2123173 2123152 2123173 I NA NA IG1902_Rv1872c-Rv1873 KEEP 2123174..2123611 2123174 2123611 + 145 15609010 - Rv1873 COG5579S V nonessential hypothetical protein KEEP 2123612..2123683 2123612 2123683 I NA NA IG1903_Rv1873-Rv1874 KEEP 2123684..2124370 2123684 2124370 + 228 15609011 - Rv1874 - VI nonessential hypothetical protein KEEP 2124371..2124380 2124371 2124380 I NA NA IG1904_Rv1874-Rv1875 KEEP 2124381..2124824 2124381 2124824 + 147 15609012 - Rv1875 - V nonessential hypothetical protein KEEP 2124825..2125339 2124825 2125339 I NA NA IG1905_Rv1875-Rv1876 KEEP 2125340..2125819 2125340 2125819 + 159 15609013 bfrA Rv1876 COG2193P I.G.14 nonessential bacterioferritin KEEP 2125820..2125903 2125820 2125903 I NA NA IG1906_Rv1876-Rv1877 KEEP 2125904..2127967 2125904 2127967 + 687 15609014 - Rv1877 COG0477GEPR III.A.6 nonessential integral membrane protein KEEP 2127968..2128021 2127968 2128021 I NA NA IG1907_Rv1877-Rv1878 KEEP 2128022..2129374 2128022 2129374 + 450 15609015 glnA3 Rv1878 COG0174E I.D.1 nonessential glutamine synthetase KEEP 2129375..2129376 2129375 2129376 I NA NA IG1908_Rv1878-Rv1879 KEEP 2129377..2130513 2129377 2130513 + 378 15609016 - Rv1879 COG2159R V nonessential hypothetical protein KEEP 2130514..2130540 2130514 2130540 I NA NA IG1909_Rv1879-Rv1880c KEEP 2130541..2131857 2130541 2131857 - 438 15609017 cyp140 Rv1880c COG2124Q IV.F nonessential cytochrome p450 140 CYP140 KEEP 2131858..2131906 2131858 2131906 I NA NA IG1910_Rv1880c-Rv1881c KEEP 2131907..2132329 2131907 2132329 - 140 15609018 lppE Rv1881c - II.C.1 nonessential lipoprotein LppE KEEP 2132330..2132369 2132330 2132369 I NA NA IG1911_Rv1881c-Rv1882c KEEP 2132370..2133203 2132370 2133203 - 277 15609019 - Rv1882c COG1028IQR VI nonessential short chain dehydrogenase KEEP 2133204..2133230 2133204 2133230 I NA NA IG1912_Rv1882c-Rv1883c KEEP 2133231..2133692 2133231 2133473 - 153 15609020 - Rv1883c - V nonessential hypothetical protein KEEP 2133231..2133692 2133474 2133475 - 153 15609020 - Rv1883c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2133231..2133692 2133476 2133692 - 153 15609020 - Rv1883c - V nonessential hypothetical protein KEEP 2133693..2133730 2133693 2133730 I NA NA IG1913_Rv1883c-Rv1884c KEEP 2133731..2134261 2133731 2133992 - 176 15609021 rpfC Rv1884c - VII nonessential resuscitation-promoting factor RpfC KEEP 2133731..2134261 2133993 2134046 - 176 15609021 rpfC Rv1884c - VII nonessential resuscitation-promoting factor RpfC Only Marin et al 2022 KEEP 2133731..2134261 2134047 2134261 - 176 15609021 rpfC Rv1884c - VII nonessential resuscitation-promoting factor RpfC KEEP 2134262..2134272 2134262 2134272 I NA NA IG1914_Rv1884c-Rv1885c KEEP 2134273..2134872 2134273 2134872 - 199 15609022 - Rv1885c COG1605E V nonessential chorismate mutase KEEP 2134873..2134889 2134873 2134889 I NA NA IG1915_Rv1885c-Rv1886c KEEP 2134890..2135867 2134890 2134921 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) KEEP 2134890..2135867 2134922 2134975 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) Only Marin et al 2022 KEEP 2134890..2135867 2134976 2135423 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) KEEP 2134890..2135867 2135424 2135493 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) Only Marin et al 2022 KEEP 2134890..2135867 2135494 2135532 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) KEEP 2134890..2135867 2135533 2135616 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) Only Marin et al 2022 KEEP 2134890..2135867 2135617 2135664 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) KEEP 2134890..2135867 2135665 2135748 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) Only Marin et al 2022 KEEP 2134890..2135867 2135749 2135867 - 325 15609023 fbpB Rv1886c COG0627R I.H.3 nonessential secreted antigen 85-B fbpB (85B) (antigen 85 complex B) (Mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) KEEP 2135868..2136257 2135868 2136257 I NA NA IG1916_Rv1886c-Rv1887 KEEP 2136258..2137400 2136258 2137400 + 380 15609024 - Rv1887 - VI nonessential hypothetical protein KEEP 2137401..2137518 2137401 2137518 I NA NA IG1917_Rv1887-Rv1888c KEEP 2137519..2138079 2137519 2138079 - 186 15609025 - Rv1888c - V nonessential transmembrane protein KEEP 2138080..2138443 2138080 2138443 I NA NA IG1918_Rv1888c-Rv1888A KEEP 2138444..2138617 2138444 2138617 - 57 57116927 - Rv1888A COG3315Q II.C.5 nonessential hypothetical protein KEEP 2138618..2138660 2138618 2138660 I NA NA IG1919_Rv1888A-Rv1889c KEEP 2138661..2139017 2138661 2139017 - 118 15609026 - Rv1889c COG3315Q V nonessential hypothetical protein KEEP 2139018..2139075 2139018 2139075 I NA NA IG1920_Rv1889c-Rv1890c KEEP 2139076..2139687 2139076 2139687 - 203 15609027 - Rv1890c COG2353S VI nonessential hypothetical protein KEEP 2139688..2139740 2139688 2139740 I NA NA IG1921_Rv1890c-Rv1891 KEEP 2139741..2140148 2139741 2140148 + 135 15609028 - Rv1891 - V nonessential hypothetical protein KEEP 2140149..2140164 2140149 2140164 I NA NA IG1922_Rv1891-Rv1892 KEEP 2140165..2140476 2140165 2140476 + 103 15609029 - Rv1892 - II.C.5 nonessential hypothetical protein KEEP 2140477..2140485 2140477 2140485 I NA NA IG1923_Rv1892-Rv1893 KEEP 2140486..2140704 2140486 2140704 + 72 15609030 - Rv1893 - V nonessential hypothetical protein KEEP 2140705..2140738 2140705 2140738 I NA NA IG1924_Rv1893-Rv1894c KEEP 2140739..2141869 2140739 2141869 - 376 15609031 - Rv1894c COG2070R V nonessential hypothetical protein KEEP 2141870..2142520 2141870 2142520 I NA NA IG1925_Rv1894c-Rv1895 KEEP 2142521..2143675 2142521 2143675 + 384 15609032 - Rv1895 COG1063ER VI nonessential dehydrogenase KEEP 2143535..2144446 2143535 2144446 - 303 15609033 - Rv1896c COG3315Q V nonessential hypothetical protein KEEP 2144447..2144450 2144447 2144450 I NA NA IG1927_Rv1896c-Rv1897c KEEP 2144451..2144882 2144451 2144882 - 143 15609034 - Rv1897c COG1490J V nonessential D-tyrosyl-tRNA deacylase KEEP 2144883..2144939 2144883 2144939 I NA NA IG1928_Rv1897c-Rv1898 KEEP 2144940..2145248 2144940 2145248 + 102 15609035 - Rv1898 COG0011S V nonessential hypothetical protein KEEP 2145214..2146245 2145214 2146057 - 343 15609036 lppD Rv1899c COG2110R II.C.1 nonessential lipoprotein LppD KEEP 2145214..2146245 2146058 2146132 - 343 15609036 lppD Rv1899c COG2110R II.C.1 nonessential lipoprotein LppD Only Marin et al 2022 KEEP 2145214..2146245 2146133 2146245 - 343 15609036 lppD Rv1899c COG2110R II.C.1 nonessential lipoprotein LppD KEEP 2146245..2147633 2146245 2147633 - 462 15609037 lipJ Rv1900c COG0596R,COG2114T II.B.5 nonessential lignin peroxidase LIPJ KEEP 2147634..2147661 2147634 2147661 I NA NA IG1931_Rv1900c-Rv1901 KEEP 2147662..2148954 2147662 2148954 + 430 15609038 cinA Rv1901 COG1058R,COG1546R III.E nonessential competence damage-inducible protein A KEEP 2148955..2149005 2148955 2149005 I NA NA IG1932_Rv1901-Rv1902c KEEP 2149006..2150274 2149006 2150274 - 422 15609039 nanT Rv1902c COG0477GEPR III.A.3 nonessential sialic acid-transport integral membrane protein NanT KEEP 2150275..2150363 2150275 2150363 I NA NA IG1933_Rv1902c-Rv1903 KEEP 2150364..2150768 2150364 2150768 + 134 15609040 - Rv1903 COG1950S II.C.4 nonessential hypothetical protein KEEP 2150769..2150953 2150769 2150953 I NA NA IG1934_Rv1903-Rv1904 KEEP 2150954..2151385 2150954 2151385 + 143 15609041 - Rv1904 COG1366T V nonessential hypothetical protein KEEP 2151386..2151432 2151386 2151432 I NA NA IG1935_Rv1904-Rv1905c KEEP 2151433..2152395 2151433 2152395 - 320 15609042 aao Rv1905c COG0665E I.A.2 nonessential D-amino acid oxidase KEEP 2152396..2152424 2152396 2152424 I NA NA IG1936_Rv1905c-Rv1906c KEEP 2152425..2152895 2152425 2152895 - 156 15609043 - Rv1906c - V nonessential hypothetical protein KEEP 2152896..2153234 2152896 2153234 I NA NA IG1937_Rv1906c-Rv1907c KEEP 2153235..2153882 2153235 2153882 - 215 15609044 - Rv1907c - VI nonessential hypothetical protein KEEP 2153883..2153888 2153883 2153888 I NA NA IG1938_Rv1907c-Rv1908c KEEP 2153889..2156111 2153889 2156111 - 740 15609045 katG Rv1908c COG0376P III.F DR-inh nonessential catalase-peroxidase-peroxynitritase T KATG KEEP 2156112..2156148 2156112 2156148 I NA NA IG1939_Rv1908c-Rv1909c DR-inh KEEP 2156149..2156601 2156149 2156601 - 150 15609046 furA Rv1909c COG0735P I.J.1 DR-inh nonessential ferric uptake regulation protein furA (fur) KEEP 2156602..2156705 2156602 2156705 I NA NA IG1940_Rv1909c-Rv1910c KEEP 2156706..2157299 2156706 2156797 - 197 15609047 - Rv1910c COG1881R II.C.2 nonessential hypothetical protein KEEP 2156706..2157299 2156798 2156878 - 197 15609047 - Rv1910c COG1881R II.C.2 nonessential hypothetical protein Only Marin et al 2022 KEEP 2156706..2157299 2156879 2157299 - 197 15609047 - Rv1910c COG1881R II.C.2 nonessential hypothetical protein KEEP 2157300..2157381 2157300 2157381 I NA NA IG1941_Rv1910c-Rv1911c KEEP 2157382..2157987 2157382 2157476 - 201 15609048 lppC Rv1911c COG1881R II.C.1 nonessential lipoprotein LppC KEEP 2157382..2157987 2157477 2157557 - 201 15609048 lppC Rv1911c COG1881R II.C.1 nonessential lipoprotein LppC Only Marin et al 2022 KEEP 2157382..2157987 2157558 2157987 - 201 15609048 lppC Rv1911c COG1881R II.C.1 nonessential lipoprotein LppC KEEP 2157988..2158086 2157988 2158086 I NA NA IG1942_Rv1911c-Rv1912c KEEP 2158087..2159091 2158087 2159091 - 334 15609049 fadB5 Rv1912c COG0604CR I.A.3 nonessential oxidoreductase FADB5 KEEP 2159092..2159190 2159092 2159190 I NA NA IG1943_Rv1912c-Rv1913 KEEP 2159191..2159943 2159191 2159943 + 250 15609050 - Rv1913 COG0491R V nonessential hypothetical protein KEEP 2159921..2160328 2159921 2160328 - 135 15609051 - Rv1914c - VI nonessential hypothetical protein KEEP 2160329..2160462 2160329 2160462 I NA NA IG1945_Rv1914c-Rv1915 KEEP 2160463..2161566 2160463 2161566 + 367 15609052 aceAa Rv1915 COG2224C I.B.4 nonessential isocitrate lyase KEEP 2161566..2162762 2161566 2162762 + 398 15609053 aceAb Rv1916 COG2224C I.B.4 nonessential isocitrate lyase KEEP 2162763..2162931 2162763 2162931 I NA NA IG1947_Rv1916-Rv1917c KEEP 2162932..2167311 2162932 2167311 - 1459 57116928 PPE34 Rv1917c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2167312..2167648 2167312 2167648 I NA NA IG1948_Rv1917c-Rv1918c repeat KEEP 2167649..2170612 2167649 2167845 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2167649..2170612 2167846 2167901 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2167649..2170612 2167902 2168807 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2167649..2170612 2168808 2168872 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2167649..2170612 2168873 2168885 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2167649..2170612 2168886 2168950 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2167649..2170612 2168951 2168981 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2167649..2170612 2168982 2169056 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2167649..2170612 2169057 2169059 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2167649..2170612 2169060 2169134 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2167649..2170612 2169135 2169570 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2167649..2170612 2169571 2169628 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2167649..2170612 2169629 2170280 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2167649..2170612 2170281 2170334 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2167649..2170612 2170335 2170612 - 987 57116929 PPE35 Rv1918c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2170613..2171060 2170613 2171060 I NA NA IG1949_Rv1918c-Rv1919c KEEP 2171061..2171525 2171061 2171525 - 154 15609056 - Rv1919c - II.C.2 nonessential hypothetical protein KEEP 2171526..2171622 2171526 2171622 I NA NA IG1950_Rv1919c-Rv1920 KEEP 2171623..2172486 2171623 2172486 + 287 15609057 - Rv1920 COG0204I II.C.5 nonessential hypothetical protein KEEP 2172487..2172523 2172487 2172523 I NA NA IG1951_Rv1920-Rv1921c KEEP 2172524..2173795 2172524 2173795 - 423 15609058 lppF Rv1921c COG0167F II.C.1 nonessential lipoprotein LppF KEEP 2173796..2174066 2173796 2174066 I NA NA IG1952_Rv1921c-Rv1922 KEEP 2174067..2175182 2174067 2175182 + 371 15609059 - Rv1922 COG1680V II.C.3 nonessential lipoprotein KEEP 2175173..2176513 2175173 2176513 + 446 15609060 lipD Rv1923 COG1680V II.B.5 nonessential lipase LIPD KEEP 2176514..2176549 2176514 2176549 I NA NA IG1954_Rv1923-Rv1924c KEEP 2176550..2176930 2176550 2176930 - 126 15609061 - Rv1924c - VI nonessential hypothetical protein KEEP 2176931..2177086 2176931 2177086 I NA NA IG1955_Rv1924c-Rv1925 KEEP 2177087..2178949 2177087 2178949 + 620 15609062 fadD31 Rv1925 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 2178950..2178956 2178950 2178956 I NA NA IG1956_Rv1925-Rv1926c KEEP 2178957..2179436 2178957 2179436 - 159 15609063 mpt63 Rv1926c - VI nonessential immunogenic protein MPT63 (antigen MPT63/MPB63) (16 kDa immunoprotective extracellular protein) KEEP 2179437..2179672 2179437 2179672 I NA NA IG1957_Rv1926c-Rv1927 KEEP 2179673..2180446 2179673 2180446 + 257 15609064 - Rv1927 COG3361S V nonessential hypothetical protein KEEP 2180447..2180449 2180447 2180449 I NA NA IG1958_Rv1927-Rv1928c KEEP 2180450..2181217 2180450 2181217 - 255 15609065 - Rv1928c COG1028IQR VI nonessential short chain dehydrogenase KEEP 2181218..2181261 2181218 2181261 I NA NA IG1959_Rv1928c-Rv1929c KEEP 2181262..2181906 2181262 2181375 - 214 15609066 - Rv1929c - V nonessential hypothetical protein KEEP 2181262..2181906 2181376 2181412 - 214 15609066 - Rv1929c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2181262..2181906 2181413 2181906 - 214 15609066 - Rv1929c - V nonessential hypothetical protein KEEP 2181907..2181917 2181907 2181917 I NA NA IG1960_Rv1929c-Rv1930c KEEP 2181918..2182442 2181918 2182442 - 174 15609067 - Rv1930c COG0693R V essential hypothetical protein KEEP 2182443..2182459 2182443 2182459 I NA NA IG1961_Rv1930c-Rv1931c KEEP 2182460..2183239 2182460 2183239 - 259 15609068 - Rv1931c COG2207K,COG4977K I.J.1 essential transcriptional regulatory protein KEEP 2183240..2183371 2183240 2183371 I NA NA IG1962_Rv1931c-Rv1932 KEEP 2183372..2183869 2183372 2183869 + 165 15609069 tpx Rv1932 COG2077O III.F nonessential thiol peroxidase KEEP 2183866..2184957 2183866 2184957 - 363 15609070 fadE18 Rv1933c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE18 KEEP 2184959..2186188 2184959 2186188 - 409 15609071 fadE17 Rv1934c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE17 KEEP 2186189..2186202 2186189 2186202 I NA NA IG1965_Rv1934c-Rv1935c KEEP 2186203..2187159 2186203 2187159 - 318 15609072 echA13 Rv1935c COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 2187160..2187383 2187160 2187383 I NA NA IG1966_Rv1935c-Rv1936 KEEP 2187384..2188493 2187384 2188493 + 369 15609073 - Rv1936 COG2141C VI nonessential monooxygenase KEEP 2188494..2188495 2188494 2188495 I NA NA IG1967_Rv1936-Rv1937 KEEP 2188496..2191015 2188496 2191015 + 839 15609074 - Rv1937 COG0543HC,COG0654HC VI nonessential oxygenase KEEP 2191016..2191026 2191016 2191026 I NA NA IG1968_Rv1937-Rv1938 KEEP 2191027..2192097 2191027 2192097 + 356 15609075 ephB Rv1938 COG0596R III.F nonessential epoxide hydrolase EphB KEEP 2192094..2192609 2192094 2192609 + 171 15609076 - Rv1939 COG1853R I.B.7 essential oxidoreductase KEEP 2192606..2193667 2192606 2193008 + 353 57116930 ribA1 Rv1940 COG0108H,COG0807H I.G.9 nonessential riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) KEEP 2192606..2193667 2193009 2193021 + 353 57116930 ribA1 Rv1940 COG0108H,COG0807H I.G.9 nonessential riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) Only Marin et al 2022 KEEP 2192606..2193667 2193022 2193667 + 353 57116930 ribA1 Rv1940 COG0108H,COG0807H I.G.9 nonessential riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) KEEP 2193664..2194434 2193664 2194434 + 256 15609078 - Rv1941 COG1028IQR VI nonessential short-chain type dehydrogenase/reductase KEEP 2194435..2194643 2194435 2194643 I NA NA IG1972_Rv1941-Rv1942c KEEP 2194644..2194973 2194644 2194973 - 109 15609079 - Rv1942c COG2337T V nonessential hypothetical protein KEEP 2194970..2195347 2194970 2195347 - 125 15609080 - Rv1943c - V nonessential hypothetical protein KEEP 2195344..2195934 2195344 2195905 - 196 15609081 - Rv1944c COG0653U V nonessential hypothetical protein KEEP 2195344..2195934 2195906 2195934 - 196 15609081 - Rv1944c COG0653U V nonessential hypothetical protein Only Marin et al 2022 KEEP 2195935..2195988 2195935 2195988 I NA NA IG1975_Rv1944c-Rv1945 Annotation + Marin et al 2022 DISCARD 2195989..2197353 2195989 2196780 + 454 15609082 - Rv1945 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2195989..2197353 2196781 2196855 + 454 15609082 - Rv1945 - V repeat13E12 nonessential hypothetical protein KEEP 2195989..2197353 2196856 2197248 + 454 15609082 - Rv1945 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2195989..2197353 2197249 2197278 + 454 15609082 - Rv1945 - V repeat13E12 nonessential hypothetical protein KEEP 2195989..2197353 2197279 2197353 + 454 15609082 - Rv1945 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2197354..2197507 2197354 2197365 I NA NA IG1976_Rv1945-Rv1946c Annotation + Marin et al 2022 DISCARD 2197354..2197507 2197366 2197507 I NA NA IG1976_Rv1945-Rv1946c KEEP 2197508..2197960 2197508 2197960 - 150 15609083 lppG Rv1946c - II.C.1 nonessential lipoprotein KEEP 2197961..2198023 2197961 2198023 I NA NA IG1977_Rv1946c-Rv1947 KEEP 2198024..2198425 2198024 2198425 + 133 15609084 - Rv1947 - VI nonessential hypothetical protein KEEP 2198426..2198713 2198426 2198684 I NA NA IG1978_Rv1947-Rv1948c KEEP 2198426..2198713 2198685 2198713 I NA NA IG1978_Rv1947-Rv1948c Only Marin et al 2022 KEEP 2198714..2199064 2198714 2198819 - 116 15609085 - Rv1948c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 2198714..2199064 2198820 2199064 - 116 15609085 - Rv1948c - VI nonessential hypothetical protein KEEP 2199065..2199074 2199065 2199074 I NA NA IG1979_Rv1948c-Rv1949c KEEP 2199075..2200034 2199075 2200034 - 319 15609086 - Rv1949c - V nonessential hypothetical protein KEEP 2199998..2200189 2199998 2200189 - 63 15609087 - Rv1950c - V nonessential hypothetical protein KEEP 2200190..2200486 2200190 2200486 - 98 15609088 - Rv1951c - V nonessential hypothetical protein KEEP 2200487..2200725 2200487 2200725 I NA NA IG1982_Rv1951c-Rv1952 KEEP 2200726..2200941 2200726 2200941 + 71 15609089 - Rv1952 - V nonessential hypothetical protein KEEP 2200938..2201249 2200938 2201249 + 103 15609090 - Rv1953 COG1487R V nonessential hypothetical protein KEEP 2201223..2201744 2201223 2201744 - 173 15609091 - Rv1954c - VI nonessential hypothetical protein KEEP 2201584..2202096 2201584 2202096 + 170 15609092 - Rv1955 COG4679S VI nonessential hypothetical protein KEEP 2202097..2202137 2202097 2202137 I NA NA IG1986_Rv1955-Rv1956 KEEP 2202138..2202587 2202138 2202587 + 149 15609093 - Rv1956 COG1396K I.J.1 nonessential transcriptional regulatory protein KEEP 2202584..2203129 2202584 2203129 + 181 15609094 - Rv1957 - VI nonessential hypothetical protein KEEP 2203018..2203632 2203018 2203632 - 204 15609095 - Rv1958c - VI nonessential hypothetical protein KEEP 2203633..2203680 2203633 2203680 I NA NA IG1989_Rv1958c-Rv1959c KEEP 2203681..2203977 2203681 2203977 - 98 15609096 - Rv1959c COG3668R V nonessential hypothetical protein KEEP 2203974..2204225 2203974 2204225 - 83 15609097 - Rv1960c COG3609K V nonessential hypothetical protein KEEP 2204212..2204706 2204212 2204706 + 164 15609098 - Rv1961 - VI nonessential hypothetical protein KEEP 2204707..2204865 2204707 2204865 I NA NA IG1992_Rv1961-Rv1962c KEEP 2204866..2205273 2204866 2205273 - 135 15609099 - Rv1962c COG1848R V nonessential hypothetical protein KEEP 2205274..2205581 2205274 2205581 I NA NA IG1993_Rv1962c-Rv1963c KEEP 2205582..2206802 2205582 2206802 - 406 15609100 mce3R Rv1963c COG1309K I.J.1 essential transcriptional repressor (probably TETR-family) MCE3R KEEP 2206803..2207699 2206803 2207699 I NA NA IG1994_Rv1963c-Rv1964 KEEP 2207700..2208497 2207700 2208497 + 265 15609101 yrbE3A Rv1964 COG0767Q IV.A nonessential integral membrane protein YrbE3A KEEP 2208498..2208506 2208498 2208506 I NA NA IG1995_Rv1964-Rv1965 KEEP 2208507..2209322 2208507 2209322 + 271 15609102 yrbE3B Rv1965 COG0767Q IV.A nonessential integral membrane protein YrbE3b KEEP 2209323..2209326 2209323 2209326 I NA NA IG1996_Rv1965-Rv1966 KEEP 2209327..2210604 2209327 2210604 + 425 57116931 mce3A Rv1966 COG1463Q IV.A nonessential MCE-family protein MCE3A KEEP 2210601..2211629 2210601 2211629 + 342 15609104 mce3B Rv1967 COG1463Q IV.A nonessential MCE-family protein MCE3B KEEP 2211626..2212858 2211626 2212858 + 410 15609105 mce3C Rv1968 COG1463Q IV.A nonessential MCE-family protein MCE3C KEEP 2212855..2214126 2212855 2214126 + 423 15609106 mce3D Rv1969 COG1463Q IV.A nonessential MCE-family protein MCE3D KEEP 2214123..2215256 2214123 2215256 + 377 15609107 lprM Rv1970 COG1463Q II.C.1 nonessential MCE-family lipoprotein LprM KEEP 2215257..2216570 2215257 2216570 + 437 15609108 mce3F Rv1971 COG1463Q IV.A nonessential MCE-family protein MCE3F KEEP 2216571..2216591 2216571 2216591 I NA NA IG2002_Rv1971-Rv1972 KEEP 2216592..2217167 2216592 2217167 + 191 15609109 - Rv1972 - II.C.5 nonessential mce associated membrane protein KEEP 2217164..2217646 2217164 2217646 + 160 15609110 - Rv1973 - II.C.5 nonessential MCE associated membrane protein KEEP 2217647..2217658 2217647 2217658 I NA NA IG2004_Rv1973-Rv1974 KEEP 2217659..2218036 2217659 2218036 + 125 15609111 - Rv1974 - II.C.4 essential hypothetical protein KEEP 2218037..2218051 2218037 2218051 I NA NA IG2005_Rv1974-Rv1975 KEEP 2218052..2218717 2218052 2218717 + 221 15609112 - Rv1975 - V nonessential hypothetical protein KEEP 2218718..2218843 2218718 2218843 I NA NA IG2006_Rv1975-Rv1976c KEEP 2218844..2219251 2218844 2219251 - 135 15609113 - Rv1976c - V nonessential hypothetical protein KEEP 2219252..2219753 2219252 2219753 I NA NA IG2007_Rv1976c-Rv1977 KEEP 2219754..2220800 2219754 2220800 + 348 15609114 - Rv1977 COG0501O II.B.3 nonessential hypothetical protein KEEP 2220801..2220907 2220801 2220907 I NA NA IG2008_Rv1977-Rv1978 KEEP 2220908..2221756 2220908 2221756 + 282 15609115 - Rv1978 COG0500QR V nonessential hypothetical protein KEEP 2221719..2223164 2221719 2223164 - 481 15609116 - Rv1979c COG0531E VI nonessential permease KEEP 2223165..2223342 2223165 2223342 I NA NA IG2010_Rv1979c-Rv1980c KEEP 2223343..2224029 2223343 2224029 - 228 15609117 mpt64 Rv1980c - II.C.2 nonessential immunogenic protein MPT64 (antigen MPT64/MPB64) KEEP 2224030..2224219 2224030 2224219 I NA NA IG2011_Rv1980c-Rv1981c KEEP 2224220..2225188 2224220 2225188 - 322 57116932 nrdF Rv1981c COG0208F I.F.3 nonessential ribonucleotide-diphosphate reductase subunit beta KEEP 2225189..2225412 2225189 2225412 I NA NA IG2012_Rv1981c-Rv1982c KEEP 2225413..2225832 2225413 2225832 - 139 15609119 - Rv1982c COG3742S V nonessential hypothetical protein KEEP 2225833..2226243 2225833 2226243 I NA NA IG2013_Rv1982c-Rv1983 KEEP 2226244..2227920 2226244 2227920 + 558 57116933 PE_PGRS35 Rv1983 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2227908..2228561 2227908 2228561 - 217 15609121 cfp21 Rv1984c - II.C.2 nonessential cutinase precursor CFP21 KEEP 2228562..2228990 2228562 2228990 I NA NA IG2015_Rv1984c-Rv1985c KEEP 2228991..2229902 2228991 2229902 - 303 15609122 - Rv1985c COG0583K I.J.1 nonessential chromosome replication initiation inhibitor protein KEEP 2229903..2230010 2229903 2230010 I NA NA IG2016_Rv1985c-Rv1986 KEEP 2230011..2230610 2230011 2230610 + 199 15609123 - Rv1986 COG1279R II.C.5 nonessential integral membrane protein KEEP 2230611..2231025 2230611 2230719 I NA NA IG2017_Rv1986-Rv1987 KEEP 2230611..2231025 2230720 2230773 I NA NA IG2017_Rv1986-Rv1987 Only Marin et al 2022 KEEP 2230611..2231025 2230774 2231025 I NA NA IG2017_Rv1986-Rv1987 KEEP 2231026..2231454 2231026 2231454 + 142 15609124 - Rv1987 - II.C.2 nonessential chitinase KEEP 2231455..2231679 2231455 2231679 I NA NA IG2018_Rv1987-Rv1988 KEEP 2231680..2232219 2231680 2232219 + 179 15609125 - Rv1988 COG0030J IV.H nonessential methyltransferase KEEP 2232220..2232738 2232220 2232738 I NA NA IG2019_Rv1988-Rv1989c KEEP 2232739..2233299 2232739 2233299 - 186 15609126 - Rv1989c COG5654S VI nonessential hypothetical protein KEEP 2233296..2233637 2233296 2233637 - 113 15609127 - Rv1990c COG1396K VI nonessential transcriptional regulatory protein KEEP 2233638..2233880 2233638 2233880 I NA NA IG2021_Rv1990c-Rv1990A KEEP 2233881..2234216 2233881 2234216 - 111 57116934 - Rv1990A COG1028IQR I.J.1 nonessential dehydrogenase KEEP 2234217..2234304 2234217 2234304 I NA NA IG2022_Rv1990A-Rv1991c KEEP 2234305..2234649 2234305 2234649 - 114 15609128 - Rv1991c COG2337T V nonessential hypothetical protein KEEP 2234650..2234990 2234650 2234990 I NA NA IG2023_Rv1991c-Rv1992c KEEP 2234991..2237306 2234991 2237306 - 771 15609129 ctpG Rv1992c COG2217P III.A.2 nonessential metal cation transporter P-type ATPase G CtpG KEEP 2237303..2237575 2237303 2237575 - 90 15609130 - Rv1993c - V nonessential hypothetical protein KEEP 2237576..2237627 2237576 2237627 I NA NA IG2025_Rv1993c-Rv1994c KEEP 2237628..2237984 2237628 2237984 - 118 15609131 - Rv1994c COG0640K I.J.1 nonessential transcriptional regulatory protein KEEP 2237985..2238140 2237985 2238140 I NA NA IG2026_Rv1994c-Rv1995 KEEP 2238141..2238908 2238141 2238908 + 255 15609132 - Rv1995 COG3945S VI nonessential hypothetical protein KEEP 2238909..2239003 2238909 2239003 I NA NA IG2027_Rv1995-Rv1996 KEEP 2239004..2239957 2239004 2239957 + 317 15609133 - Rv1996 COG0589T V nonessential hypothetical protein KEEP 2239958..2240158 2239958 2240158 I NA NA IG2028_Rv1996-Rv1997 KEEP 2240159..2242876 2240159 2242876 + 905 15609134 ctpF Rv1997 COG0474P III.A.2 nonessential metal cation transporter P-type ATPase A CtpF KEEP 2242877..2242944 2242877 2242944 I NA NA IG2029_Rv1997-Rv1998c KEEP 2242945..2243721 2242945 2243721 - 258 15609135 - Rv1998c COG2513G V nonessential hypothetical protein KEEP 2243722..2243815 2243722 2243815 I NA NA IG2030_Rv1998c-Rv1999c KEEP 2243816..2245138 2243816 2244991 - 440 15609136 - Rv1999c COG0531E II.C.5 nonessential integral membrane protein KEEP 2243816..2245138 2244992 2245020 - 440 15609136 - Rv1999c COG0531E II.C.5 nonessential integral membrane protein Only Marin et al 2022 KEEP 2243816..2245138 2245021 2245138 - 440 15609136 - Rv1999c COG0531E II.C.5 nonessential integral membrane protein KEEP 2245139..2245208 2245139 2245208 I NA NA IG2031_Rv1999c-Rv2000 KEEP 2245209..2246822 2245209 2246822 + 537 15609137 - Rv2000 COG0493ER,COG0665E VI nonessential hypothetical protein KEEP 2246823..2246831 2246823 2246831 I NA NA IG2032_Rv2000-Rv2001 KEEP 2246832..2247584 2246832 2247584 + 250 15609138 - Rv2001 COG3884I V nonessential hypothetical protein KEEP 2247585..2247659 2247585 2247659 I NA NA IG2033_Rv2001-Rv2002 KEEP 2247660..2248442 2247660 2248442 + 260 15609139 fabG3 Rv2002 COG1028IQR I.H.1 nonessential 20-beta-hydroxysteroid dehydrogenase KEEP 2248443..2248562 2248443 2248562 I NA NA IG2034_Rv2002-Rv2003c KEEP 2248563..2249420 2248563 2249420 - 285 15609140 - Rv2003c COG0500QR V nonessential hypothetical protein KEEP 2249421..2249477 2249421 2249477 I NA NA IG2035_Rv2003c-Rv2004c KEEP 2249478..2250974 2249478 2250974 - 498 15609141 - Rv2004c COG0645R,COG2187S V essential hypothetical protein KEEP 2250975..2250995 2250975 2250995 I NA NA IG2036_Rv2004c-Rv2005c KEEP 2250996..2251883 2250996 2251883 - 295 15609142 - Rv2005c COG0589T V nonessential hypothetical protein KEEP 2251884..2252001 2251884 2252001 I NA NA IG2037_Rv2005c-Rv2006 KEEP 2252002..2255985 2252002 2255985 + 1327 57116935 otsB1 Rv2006 COG0637R,COG1554G,COG1877G III.E nonessential trehalose-6-phosphate phosphatase OtsB1 KEEP 2255986..2256083 2255986 2256083 I NA NA IG2038_Rv2006-Rv2007c KEEP 2256084..2256428 2256084 2256428 - 114 15609144 fdxA Rv2007c COG1146C I.B.6c nonessential ferredoxin FDXA KEEP 2256429..2256616 2256429 2256616 I NA NA IG2039_Rv2007c-Rv2008c KEEP 2256617..2257942 2256617 2257942 - 441 15609145 - Rv2008c COG1373R,COG4108J V nonessential hypothetical protein KEEP 2257943..2258029 2257943 2258029 I NA NA IG2040_Rv2008c-Rv2009 KEEP 2258030..2258272 2258030 2258272 + 80 15609146 - Rv2009 COG5450K V nonessential hypothetical protein KEEP 2258273..2258671 2258273 2258671 + 132 15609147 - Rv2010 COG1487R V nonessential hypothetical protein KEEP 2258672..2258853 2258672 2258853 I NA NA IG2042_Rv2010-Rv2011c KEEP 2258854..2259285 2258854 2259285 - 143 15609148 - Rv2011c COG1846K V nonessential hypothetical protein KEEP 2259286..2259325 2259286 2259325 I NA NA IG2043_Rv2011c-Rv2012 KEEP 2259326..2259820 2259326 2259820 + 164 15609149 - Rv2012 COG5562R V nonessential hypothetical protein KEEP 2259821..2260664 2259821 2260252 I NA NA IG2044_Rv2012-Rv2013 KEEP 2259821..2260664 2260253 2260309 I NA NA IG2044_Rv2012-Rv2013 Annotation + Marin et al 2022 DISCARD 2259821..2260664 2260310 2260342 I NA NA IG2044_Rv2012-Rv2013 KEEP 2259821..2260664 2260343 2260439 I NA NA IG2044_Rv2012-Rv2013 Annotation + Marin et al 2022 DISCARD 2259821..2260664 2260440 2260664 I NA NA IG2044_Rv2012-Rv2013 KEEP 2260665..2261144 2260665 2261144 + 159 57116936 - Rv2013 COG3547L IV.B.1 phage essential transposase KEEP 2261098..2261688 2261098 2261439 + 196 57116937 - Rv2014 COG3547L IV.B.1 phage nonessential transposase KEEP 2261098..2261688 2261440 2261518 + 196 57116937 - Rv2014 COG3547L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2261098..2261688 2261519 2261688 + 196 57116937 - Rv2014 COG3547L IV.B.1 phage nonessential transposase KEEP 2261689..2261815 2261689 2261815 I NA NA IG2046_Rv2014-Rv2015c KEEP 2261816..2263072 2261816 2262003 - 418 15609152 - Rv2015c - V nonessential hypothetical protein KEEP 2261816..2263072 2262004 2263072 - 418 15609152 - Rv2015c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2263073..2263425 2263073 2263175 I NA NA IG2047_Rv2015c-Rv2016 Only Marin et al 2022 KEEP 2263073..2263425 2263176 2263425 I NA NA IG2047_Rv2015c-Rv2016 KEEP 2263426..2264001 2263426 2264001 + 191 15609153 - Rv2016 - VI nonessential hypothetical protein KEEP 2263998..2265038 2263998 2265038 + 346 15609154 - Rv2017 COG1396K,COG2856E I.J.1 nonessential transcriptional regulatory protein KEEP 2265039..2265279 2265039 2265279 I NA NA IG2049_Rv2017-Rv2018 KEEP 2265280..2265999 2265280 2265999 + 239 15609155 - Rv2018 COG2442S V nonessential hypothetical protein KEEP 2265989..2266405 2265989 2266405 + 138 15609156 - Rv2019 - VI nonessential hypothetical protein KEEP 2266406..2266420 2266406 2266420 I NA NA IG2051_Rv2019-Rv2020c KEEP 2266421..2266720 2266421 2266485 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266486 2266487 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266488 2266506 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266507 2266508 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266509 2266515 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266516 2266517 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266518 2266548 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266549 2266550 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266551 2266551 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266552 2266553 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266554 2266581 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266582 2266583 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266584 2266596 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266597 2266598 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266599 2266602 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266603 2266604 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266605 2266622 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266421..2266720 2266623 2266624 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2266421..2266720 2266625 2266720 - 99 15609157 - Rv2020c COG4889R V nonessential hypothetical protein KEEP 2266721..2266804 2266721 2266804 I NA NA IG2052_Rv2020c-Rv2021c KEEP 2266805..2267110 2266805 2267110 - 101 15609158 - Rv2021c COG1396K I.J.1 nonessential transcriptional regulatory protein KEEP 2267111..2267118 2267111 2267118 I NA NA IG2053_Rv2021c-Rv2022c KEEP 2267119..2267724 2267119 2267724 - 201 15609159 - Rv2022c COG4683S V nonessential hypothetical protein KEEP 2267725..2267748 2267725 2267748 I NA NA IG2054_Rv2022c-Rv2023c KEEP 2267749..2268108 2267749 2268108 - 119 15609160 - Rv2023c - VI nonessential hypothetical protein KEEP 2268109..2268692 2268109 2268692 I NA NA IG2055_Rv2023c-Rv2024c KEEP 2268693..2270240 2268693 2268720 - 515 15609161 - Rv2024c COG4889R V nonessential hypothetical protein KEEP 2268693..2270240 2268721 2268725 - 515 15609161 - Rv2024c COG4889R V nonessential hypothetical protein Only Marin et al 2022 KEEP 2268693..2270240 2268726 2270240 - 515 15609161 - Rv2024c COG4889R V nonessential hypothetical protein KEEP 2270241..2270749 2270241 2270749 I NA NA IG2056_Rv2024c-Rv2025c KEEP 2270750..2271748 2270750 2271748 - 332 15609162 - Rv2025c COG0053P II.C.5 nonessential hypothetical protein KEEP 2271749..2271862 2271749 2271862 I NA NA IG2057_Rv2025c-Rv2026c KEEP 2271863..2272747 2271863 2272747 - 294 15609163 - Rv2026c COG0589T V essential hypothetical protein KEEP 2272748..2272786 2272748 2272786 I NA NA IG2058_Rv2026c-Rv2027c KEEP 2272787..2274508 2272787 2274508 - 573 15609164 - Rv2027c COG2203T,COG4585T I.J.2 nonessential histidine kinase response regulator KEEP 2274509..2274568 2274509 2274568 I NA NA IG2059_Rv2027c-Rv2028c KEEP 2274569..2275408 2274569 2275408 - 279 15609165 - Rv2028c COG0589T V nonessential hypothetical protein KEEP 2275405..2276424 2275405 2276424 - 339 15609166 pfkB Rv2029c COG1105G I.B.1 nonessential phosphofructokinase PfkB (phosphohexokinase) KEEP 2276425..2276440 2276425 2276440 I NA NA IG2061_Rv2029c-Rv2030c KEEP 2276441..2278486 2276441 2278486 - 681 15609167 - Rv2030c COG1926R,COG2312R V nonessential hypothetical protein KEEP 2278487..2278497 2278487 2278497 I NA NA IG2062_Rv2030c-Rv2031c KEEP 2278498..2278932 2278498 2278932 - 144 15609168 hspX Rv2031c COG0071O III.B nonessential heat shock protein hspX KEEP 2278933..2279128 2278933 2279128 I NA NA IG2063_Rv2031c-Rv2032 KEEP 2279129..2280124 2279129 2280124 + 331 15609169 acg Rv2032 COG0778C V nonessential hypothetical protein KEEP 2280125..2280239 2280125 2280239 I NA NA IG2064_Rv2032-Rv2033c KEEP 2280240..2281082 2280240 2281082 - 280 15609170 - Rv2033c - V nonessential hypothetical protein KEEP 2281083..2281293 2281083 2281293 I NA NA IG2065_Rv2033c-Rv2034 KEEP 2281294..2281617 2281294 2281617 + 107 15609171 - Rv2034 COG0640K I.J.1 nonessential ArsR-type repressor protein KEEP 2281614..2282102 2281614 2282102 + 162 15609172 - Rv2035 - V nonessential hypothetical protein KEEP 2282099..2282740 2282099 2282740 + 213 15609173 - Rv2036 - IV.D nonessential hypothetical protein KEEP 2282741..2282746 2282741 2282746 I NA NA IG2068_Rv2036-Rv2037c KEEP 2282747..2283721 2282747 2283721 - 324 15609174 - Rv2037c COG1752R II.C.5 nonessential transmembrane protein KEEP 2283723..2284796 2283723 2284796 - 357 15609175 - Rv2038c COG3839G III.A.3 essential sugar-transport ATP-binding protein ABC transporter KEEP 2284797..2284798 2284797 2284798 I NA NA IG2070_Rv2038c-Rv2039c KEEP 2284799..2285641 2284799 2285641 - 280 15609176 - Rv2039c COG0395G III.A.3 nonessential sugar-transport integral membrane protein ABC transporter KEEP 2285628..2286530 2285628 2286530 - 300 15609177 - Rv2040c COG1175G III.A.3 essential sugar-transport integral membrane protein ABC transporter KEEP 2286527..2287846 2286527 2287846 - 439 15609178 - Rv2041c COG1653G III.A.3 essential sugar-binding lipoprotein KEEP 2287847..2287883 2287847 2287883 I NA NA IG2073_Rv2041c-Rv2042c KEEP 2287884..2288681 2287884 2288681 - 265 15609179 - Rv2042c - V nonessential hypothetical protein KEEP 2288681..2289241 2288681 2289241 - 186 15609180 pncA Rv2043c COG1335Q IV.D DR-pza nonessential pyrazinamidase/nicotinamidas PNCA (PZase) KEEP 2289242..2289281 2289242 2289281 I NA NA IG2075_Rv2043c-Rv2044c DR-pza KEEP 2289282..2289599 2289282 2289599 - 105 15609181 - Rv2044c - V nonessential hypothetical protein KEEP 2289600..2289684 2289600 2289684 I NA NA IG2076_Rv2044c-Rv2045c KEEP 2289685..2291220 2289685 2291220 - 511 15609182 lipT Rv2045c COG2272I II.B.5 nonessential carboxylesterase LipT KEEP 2291221..2291268 2291221 2291268 I NA NA IG2077_Rv2045c-Rv2046 KEEP 2291269..2291925 2291269 2291925 + 218 15609183 lppI Rv2046 COG0145EQ II.C.1 nonessential lipoprotein lppI KEEP 2291926..2291961 2291926 2291961 I NA NA IG2078_Rv2046-Rv2047c KEEP 2291962..2294526 2291962 2294526 - 854 15609184 - Rv2047c COG0451MG,COG0574G V nonessential hypothetical protein KEEP 2294527..2294530 2294527 2294530 I NA NA IG2079_Rv2047c-Rv2048c KEEP 2294531..2306986 2294531 2294814 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2294815 2294911 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Marin et al 2022 + homoplasy analysis DISCARD 2294531..2306986 2294912 2295173 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2295174 2295242 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2295243 2295288 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2295289 2296015 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Marin et al 2022 + homoplasy analysis DISCARD 2294531..2306986 2296016 2296028 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2296029 2296427 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Marin et al 2022 + homoplasy analysis DISCARD 2294531..2306986 2296428 2296958 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2296959 2297045 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2297046 2298088 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2298089 2298160 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2298161 2299185 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2299186 2300128 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2300129 2300206 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2300207 2300388 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2300389 2300445 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2300446 2300580 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Marin et al 2022 + homoplasy analysis DISCARD 2294531..2306986 2300581 2300910 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2300911 2301007 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2301008 2301263 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2301264 2301332 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2301333 2301378 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2301379 2302105 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Marin et al 2022 + homoplasy analysis DISCARD 2294531..2306986 2302106 2302111 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2302112 2302517 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2302518 2303045 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2303046 2303132 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2303133 2304130 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2304131 2304202 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2304203 2305254 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2305255 2306197 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Only Marin et al 2022 KEEP 2294531..2306986 2306198 2306275 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2306276 2306457 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Marin et al 2022 + homoplasy analysis DISCARD 2294531..2306986 2306458 2306511 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2294531..2306986 2306512 2306646 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 Marin et al 2022 + homoplasy analysis DISCARD 2294531..2306986 2306647 2306986 - 4151 15609185 pks12 Rv2048c COG3321Q I.I essential polyketide synthase pks12 KEEP 2306987..2307292 2306987 2307292 I NA NA IG2080_Rv2048c-Rv2049c KEEP 2307293..2307517 2307293 2307517 - 74 15609186 - Rv2049c - VI nonessential hypothetical protein KEEP 2307518..2307820 2307518 2307820 I NA NA IG2081_Rv2049c-Rv2050 KEEP 2307821..2308156 2307821 2308156 + 111 15609187 - Rv2050 - V essential hypothetical protein KEEP 2308131..2310755 2308131 2310755 - 874 15609188 ppm1 Rv2051c COG0463M,COG0815M VII nonessential polyprenol-monophosphomannose synthase Ppm1 KEEP 2310756..2310912 2310756 2310912 I NA NA IG2083_Rv2051c-Rv2052c KEEP 2310913..2312517 2310913 2312517 - 534 15609189 - Rv2052c COG1574R V nonessential hypothetical protein KEEP 2312518..2312521 2312518 2312521 I NA NA IG2084_Rv2052c-Rv2053c KEEP 2312522..2313049 2312522 2313049 - 175 15609190 fxsA Rv2053c - II.C.5 nonessential FxsA KEEP 2313050..2313124 2313050 2313124 I NA NA IG2085_Rv2053c-Rv2054 KEEP 2313125..2313838 2313125 2313838 + 237 15609191 - Rv2054 COG0412Q V nonessential hypothetical protein KEEP 2313839..2314086 2313839 2314086 I NA NA IG2086_Rv2054-Rv2055c KEEP 2314087..2314353 2314087 2314353 - 88 15609192 rpsR Rv2055c COG0238J II.A.1 nonessential 30S ribosomal protein S18 KEEP 2314354..2314659 2314354 2314659 - 101 15609193 rpsN Rv2056c COG0199J II.A.1 nonessential 30S ribosomal protein S14 KEEP 2314661..2314825 2314661 2314825 - 54 57116938 rpmG Rv2057c COG0267J II.A.1 nonessential 50S ribosomal protein L33 KEEP 2314825..2315061 2314825 2315061 - 78 15609195 rpmB Rv2058c COG0227J II.A.1 nonessential 50S ribosomal protein L28 KEEP 2315062..2315173 2315062 2315173 I NA NA IG2090_Rv2058c-Rv2059 KEEP 2315174..2316709 2315174 2316709 + 511 15609196 - Rv2059 COG0803P V nonessential hypothetical protein KEEP 2316279..2316680 2316279 2316680 + 133 15609197 - Rv2060 COG1108P II.C.5 nonessential integral membrane protein KEEP 2316681..2317085 2316681 2317085 - 134 15609198 - Rv2061c COG3576R V nonessential hypothetical protein KEEP 2317086..2317168 2317086 2317127 I NA NA IG2093_Rv2061c-Rv2062c KEEP 2317086..2317168 2317128 2317129 I NA NA IG2093_Rv2061c-Rv2062c Only Marin et al 2022 KEEP 2317086..2317168 2317130 2317134 I NA NA IG2093_Rv2061c-Rv2062c KEEP 2317086..2317168 2317135 2317136 I NA NA IG2093_Rv2061c-Rv2062c Only Marin et al 2022 KEEP 2317086..2317168 2317137 2317168 I NA NA IG2093_Rv2061c-Rv2062c KEEP 2317169..2320753 2317169 2320753 - 1194 15609199 cobN Rv2062c COG1429H I.G.13 nonessential cobaltochelatase KEEP 2320754..2320830 2320754 2320830 I NA NA IG2094_Rv2062c-Rv2063 KEEP 2320831..2321064 2320831 2321064 + 77 57116939 - Rv2063 - V nonessential hypothetical protein KEEP 2321065..2321450 2321065 2321450 I NA NA IG2095_Rv2063-Rv2064 KEEP 2321451..2322542 2321451 2322542 + 363 15609201 cobG Rv2064 COG0155P I.G.13 nonessential cobalamin biosynthesis protein CobG KEEP 2322543..2322551 2322543 2322551 I NA NA IG2096_Rv2064-Rv2065 KEEP 2322552..2323178 2322552 2323178 + 208 15609202 cobH Rv2065 COG2082H I.G.13 nonessential precorrin-8X methylmutase KEEP 2323175..2324701 2323175 2324701 + 508 15609203 cobI Rv2066 COG1010H,COG2243H I.G.13 nonessential bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase Cob I/J KEEP 2324647..2325870 2324647 2325870 - 407 15609204 - Rv2067c COG0500QR V nonessential hypothetical protein KEEP 2325871..2325885 2325871 2325885 I NA NA IG2099_Rv2067c-Rv2068c KEEP 2325886..2326809 2325886 2326809 - 307 15609205 blaC Rv2068c COG2367V IV.D nonessential class A BETA-lactamase BLAC KEEP 2326810..2326943 2326810 2326943 I NA NA IG2100_Rv2068c-Rv2069 KEEP 2326944..2327501 2326944 2327501 + 185 15609206 sigC Rv2069 COG1595K II.A.7 nonessential RNA polymerase sigma factor SigC KEEP 2327491..2328225 2327491 2328225 - 244 15609207 cobK Rv2070c COG2099H I.G.13 nonessential cobalt-precorrin-6x reductase KEEP 2328222..2328977 2328222 2328977 - 251 15609208 cobM Rv2071c COG2875H I.G.13 nonessential precorrin-4 C11-methyltransferase CobM KEEP 2328974..2330146 2328974 2329857 - 390 15609209 cobL Rv2072c COG2241H,COG2242H I.G.13 essential precorrin-6y methyltransferase CobL KEEP 2328974..2330146 2329858 2330072 - 390 15609209 cobL Rv2072c COG2241H,COG2242H I.G.13 essential precorrin-6y methyltransferase CobL Only Marin et al 2022 KEEP 2328974..2330146 2330073 2330142 - 390 15609209 cobL Rv2072c COG2241H,COG2242H I.G.13 essential precorrin-6y methyltransferase CobL KEEP 2328974..2330146 2330143 2330146 - 390 15609209 cobL Rv2072c COG2241H,COG2242H I.G.13 essential precorrin-6y methyltransferase CobL Only Marin et al 2022 KEEP 2330147..2330213 2330147 2330213 I NA NA IG2104_Rv2072c-Rv2073c Only Marin et al 2022 KEEP 2330214..2330963 2330214 2330963 - 249 15609210 - Rv2073c COG1028IQR VI nonessential shortchain dehydrogenase KEEP 2330964..2330992 2330964 2330992 I NA NA IG2105_Rv2073c-Rv2074 KEEP 2330993..2331406 2330993 2331406 + 137 15609211 - Rv2074 - V nonessential hypothetical protein KEEP 2331407..2331415 2331407 2331415 I NA NA IG2106_Rv2074-Rv2075c KEEP 2331416..2332879 2331416 2332879 - 487 15609212 - Rv2075c - VI nonessential hypothetical protein KEEP 2332880..2333036 2332880 2333036 I NA NA IG2107_Rv2075c-Rv2076c KEEP 2333037..2333288 2333037 2333288 - 83 15609213 - Rv2076c - VI nonessential hypothetical protein KEEP 2333289..2333322 2333289 2333322 I NA NA IG2108_Rv2076c-Rv2077c KEEP 2333323..2334294 2333323 2334294 - 323 15609214 - Rv2077c - V nonessential transmembrane protein KEEP 2334295..2334594 2334295 2334594 - 99 57116940 - Rv2077A - II.C.5 nonessential hypothetical protein KEEP 2334595..2335058 2334595 2335058 I NA NA IG2110_Rv2077A-Rv2078 KEEP 2335059..2335373 2335059 2335373 + 104 15609215 - Rv2078 - VI nonessential hypothetical protein KEEP 2335355..2337325 2335355 2337325 + 656 15609216 - Rv2079 - V nonessential hypothetical protein KEEP 2337306..2337869 2337306 2337869 + 187 15609217 lppJ Rv2080 - II.C.1 nonessential lipoprotein LppJ KEEP 2337870..2338064 2337870 2337967 I NA NA IG2113_Rv2080-Rv2081c KEEP 2337870..2338064 2337968 2338064 I NA NA IG2113_Rv2080-Rv2081c Only Marin et al 2022 KEEP 2338065..2338505 2338065 2338102 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2338065..2338505 2338103 2338205 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338065..2338505 2338206 2338217 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2338065..2338505 2338218 2338414 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338065..2338505 2338415 2338416 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Marin et al 2022 + homoplasy analysis DISCARD 2338065..2338505 2338417 2338420 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338065..2338505 2338421 2338422 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2338065..2338505 2338423 2338423 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338065..2338505 2338424 2338425 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2338065..2338505 2338426 2338426 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338065..2338505 2338427 2338428 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2338065..2338505 2338429 2338429 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338065..2338505 2338430 2338431 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Marin et al 2022 + homoplasy analysis DISCARD 2338065..2338505 2338432 2338432 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338065..2338505 2338433 2338434 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2338065..2338505 2338435 2338455 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338065..2338505 2338456 2338457 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein Marin et al 2022 + homoplasy analysis DISCARD 2338065..2338505 2338458 2338505 - 146 15609218 - Rv2081c - II.C.5 nonessential transmembrane protein KEEP 2338506..2338708 2338506 2338675 I NA NA IG2114_Rv2081c-Rv2082 KEEP 2338506..2338708 2338676 2338679 I NA NA IG2114_Rv2081c-Rv2082 Marin et al 2022 + homoplasy analysis DISCARD 2338506..2338708 2338680 2338690 I NA NA IG2114_Rv2081c-Rv2082 KEEP 2338506..2338708 2338691 2338692 I NA NA IG2114_Rv2081c-Rv2082 Only Marin et al 2022 KEEP 2338506..2338708 2338693 2338699 I NA NA IG2114_Rv2081c-Rv2082 KEEP 2338506..2338708 2338700 2338704 I NA NA IG2114_Rv2081c-Rv2082 Only Marin et al 2022 KEEP 2338506..2338708 2338705 2338705 I NA NA IG2114_Rv2081c-Rv2082 KEEP 2338506..2338708 2338706 2338707 I NA NA IG2114_Rv2081c-Rv2082 Marin et al 2022 + homoplasy analysis DISCARD 2338506..2338708 2338708 2338708 I NA NA IG2114_Rv2081c-Rv2082 KEEP 2338709..2340874 2338709 2338714 + 721 15609219 - Rv2082 - V nonessential hypothetical protein KEEP 2338709..2340874 2338715 2338716 + 721 15609219 - Rv2082 - V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2338709..2340874 2338717 2338718 + 721 15609219 - Rv2082 - V nonessential hypothetical protein KEEP 2338709..2340874 2338719 2338720 + 721 15609219 - Rv2082 - V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2338709..2340874 2338721 2339362 + 721 15609219 - Rv2082 - V nonessential hypothetical protein KEEP 2338709..2340874 2339363 2339432 + 721 15609219 - Rv2082 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2338709..2340874 2339433 2339440 + 721 15609219 - Rv2082 - V nonessential hypothetical protein KEEP 2338709..2340874 2339441 2339510 + 721 15609219 - Rv2082 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2338709..2340874 2339511 2339511 + 721 15609219 - Rv2082 - V nonessential hypothetical protein KEEP 2338709..2340874 2339512 2339573 + 721 15609219 - Rv2082 - V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2338709..2340874 2339574 2339887 + 721 15609219 - Rv2082 - V nonessential hypothetical protein KEEP 2338709..2340874 2339888 2340051 + 721 15609219 - Rv2082 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2338709..2340874 2340052 2340560 + 721 15609219 - Rv2082 - V nonessential hypothetical protein KEEP 2338709..2340874 2340561 2340695 + 721 15609219 - Rv2082 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2338709..2340874 2340696 2340874 + 721 15609219 - Rv2082 - V nonessential hypothetical protein KEEP 2340871..2341815 2340871 2341428 + 314 15609220 - Rv2083 - V nonessential hypothetical protein KEEP 2340871..2341815 2341429 2341479 + 314 15609220 - Rv2083 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2340871..2341815 2341480 2341815 + 314 15609220 - Rv2083 - V nonessential hypothetical protein KEEP 2341808..2342944 2341808 2342944 + 378 15609221 - Rv2084 - VI nonessential hypothetical protein KEEP 2342945..2343026 2342945 2343026 I NA NA IG2117_Rv2084-Rv2085 KEEP 2343027..2343332 2343027 2343332 + 101 15609222 - Rv2085 - V nonessential hypothetical protein KEEP 2343311..2343916 2343311 2343916 + 201 57116941 - Rv2086 COG2801L V nonessential hypothetical protein KEEP 2343917..2343993 2343917 2343993 I NA NA IG2119_Rv2086-Rv2087 KEEP 2343994..2344224 2343994 2344224 + 76 57116942 - Rv2087 COG2801L V nonessential hypothetical protein KEEP 2344225..2344410 2344225 2344410 I NA NA IG2120_Rv2087-Rv2088 KEEP 2344411..2346180 2344411 2346180 + 589 15609225 pknJ Rv2088 COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase J KEEP 2346181..2346196 2346181 2346196 I NA NA IG2121_Rv2088-Rv2089c KEEP 2346197..2347324 2346197 2347324 - 375 15609226 pepE Rv2089c COG0006E II.B.3 nonessential dipeptidase PepE KEEP 2347325..2347372 2347325 2347372 I NA NA IG2122_Rv2089c-Rv2090 KEEP 2347373..2348554 2347373 2347385 + 393 15609227 - Rv2090 COG0258L II.A.5 nonessential 5'-3' exonuclease KEEP 2347373..2348554 2347386 2347620 + 393 15609227 - Rv2090 COG0258L II.A.5 nonessential 5'-3' exonuclease Only Marin et al 2022 KEEP 2347373..2348554 2347621 2348554 + 393 15609227 - Rv2090 COG0258L II.A.5 nonessential 5'-3' exonuclease KEEP 2348555..2348557 2348555 2348557 I NA NA IG2123_Rv2090-Rv2091c KEEP 2348558..2349292 2348558 2349292 - 244 15609228 - Rv2091c - II.C.5 nonessential hypothetical protein KEEP 2349293..2349333 2349293 2349333 I NA NA IG2124_Rv2091c-Rv2092c KEEP 2349334..2352054 2349334 2352054 - 906 15609229 helY Rv2092c COG4581L II.A.5 nonessential ATP-dependent DNA helicase HelY KEEP 2352055..2352102 2352055 2352102 I NA NA IG2125_Rv2092c-Rv2093c KEEP 2352103..2353029 2352103 2353029 - 308 15609230 tatC Rv2093c COG0805U II.C.5 essential Sec-independent protein translocase transmembrane protein tatC KEEP 2353030..2353045 2353030 2353045 I NA NA IG2126_Rv2093c-Rv2094c KEEP 2353046..2353297 2353046 2353297 - 83 15609231 tatA Rv2094c COG1826U II.C.5 nonessential twin argininte translocase protein A KEEP 2353298..2353364 2353298 2353364 I NA NA IG2127_Rv2094c-Rv2095c KEEP 2353365..2354315 2353365 2354315 - 316 15609232 - Rv2095c COG2378K V nonessential hypothetical protein KEEP 2354312..2355310 2354312 2355310 - 332 15609233 - Rv2096c COG2378K V nonessential hypothetical protein KEEP 2355311..2355318 2355311 2355318 I NA NA IG2129_Rv2096c-Rv2097c KEEP 2355319..2356677 2355319 2356677 - 452 15609234 - Rv2097c - V nonessential hypothetical protein KEEP 2356678..2358388 2356678 2356872 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2356873 2356918 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2356919 2356926 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2356927 2356933 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2356934 2357180 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2357181 2357185 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2357186 2357248 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2357249 2357268 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2357269 2357290 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2357291 2357297 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2357298 2357313 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2357314 2357321 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2357322 2357416 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2357417 2357420 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2357421 2357425 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2357426 2357607 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2357608 2357840 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2356678..2358388 2357841 2357901 I NA NA IG2130_Rv2097c-Rv2100 Annotation + Marin et al 2022 DISCARD 2356678..2358388 2357902 2358388 I NA NA IG2130_Rv2097c-Rv2100 KEEP 2358389..2360041 2358389 2358658 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2358389..2360041 2358659 2358715 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2358389..2360041 2358716 2358754 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2358389..2360041 2358755 2358832 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2358389..2360041 2358833 2358917 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2358389..2360041 2358918 2358991 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2358389..2360041 2358992 2358994 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2358389..2360041 2358995 2359057 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2358389..2360041 2359058 2359162 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2358389..2360041 2359163 2359213 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2358389..2360041 2359214 2359553 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2358389..2360041 2359554 2359613 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2358389..2360041 2359614 2359777 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2358389..2360041 2359778 2359852 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2358389..2360041 2359853 2359922 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2358389..2360041 2359923 2359982 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 2358389..2360041 2359983 2360041 + 550 15609237 - Rv2100 - V repeat13E12 nonessential hypothetical protein KEEP 2360042..2360239 2360042 2360239 I NA NA IG2131_Rv2100-Rv2101 KEEP 2360240..2363281 2360240 2360649 + 1013 15609238 helZ Rv2101 COG0553KL II.A.5 nonessential helicase HelZ KEEP 2360240..2363281 2360650 2360660 + 1013 15609238 helZ Rv2101 COG0553KL II.A.5 nonessential helicase HelZ Only Marin et al 2022 KEEP 2360240..2363281 2360661 2360729 + 1013 15609238 helZ Rv2101 COG0553KL II.A.5 nonessential helicase HelZ KEEP 2360240..2363281 2360730 2360740 + 1013 15609238 helZ Rv2101 COG0553KL II.A.5 nonessential helicase HelZ Only Marin et al 2022 KEEP 2360240..2363281 2360741 2361907 + 1013 15609238 helZ Rv2101 COG0553KL II.A.5 nonessential helicase HelZ KEEP 2360240..2363281 2361908 2361909 + 1013 15609238 helZ Rv2101 COG0553KL II.A.5 nonessential helicase HelZ Only Marin et al 2022 KEEP 2360240..2363281 2361910 2363281 + 1013 15609238 helZ Rv2101 COG0553KL II.A.5 nonessential helicase HelZ KEEP 2363282..2363390 2363282 2363390 I NA NA IG2132_Rv2101-Rv2102 KEEP 2363391..2364107 2363391 2363679 + 238 15609239 - Rv2102 COG4279S V nonessential hypothetical protein KEEP 2363391..2364107 2363680 2363682 + 238 15609239 - Rv2102 COG4279S V nonessential hypothetical protein Only Marin et al 2022 KEEP 2363391..2364107 2363683 2364107 + 238 15609239 - Rv2102 COG4279S V nonessential hypothetical protein KEEP 2364086..2364520 2364086 2364520 - 144 15609240 - Rv2103c COG1487R,COG1848R V nonessential hypothetical protein KEEP 2364521..2364526 2364521 2364526 I NA NA IG2134_Rv2103c-Rv2104c KEEP 2364527..2364781 2364527 2364781 - 84 15609241 - Rv2104c - V nonessential hypothetical protein KEEP 2364782..2365464 2364782 2365406 I NA NA IG2135_Rv2104c-Rv2105 KEEP 2364782..2365464 2365407 2365464 I NA NA IG2135_Rv2104c-Rv2105 Annotation + Marin et al 2022 DISCARD 2365465..2365791 2365465 2365791 + 108 15609242 - Rv2105 COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2365788..2366726 2365788 2366726 + 312 15609243 - Rv2106 COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2366727..2367358 2366727 2366778 I NA NA IG2137_Rv2106-Rv2107 repeat Annotation + Marin et al 2022 DISCARD 2366727..2367358 2366779 2366888 I NA NA IG2137_Rv2106-Rv2107 repeat KEEP 2366727..2367358 2366889 2366967 I NA NA IG2137_Rv2106-Rv2107 repeat Annotation + Marin et al 2022 DISCARD 2366727..2367358 2366968 2367027 I NA NA IG2137_Rv2106-Rv2107 repeat KEEP 2366727..2367358 2367028 2367060 I NA NA IG2137_Rv2106-Rv2107 repeat Annotation + Marin et al 2022 DISCARD 2366727..2367358 2367061 2367358 I NA NA IG2137_Rv2106-Rv2107 repeat KEEP 2367359..2367655 2367359 2367655 + 98 57116945 PE22 Rv2107 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 2367656..2367710 2367656 2367710 I NA NA IG2138_Rv2107-Rv2108 repeat KEEP 2367711..2368442 2367711 2368442 + 243 57116946 PPE36 Rv2108 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2368443..2368982 2368443 2368982 I NA NA IG2139_Rv2108-Rv2109c KEEP 2368983..2369729 2368983 2369729 - 248 15609246 prcA Rv2109c COG0638O II.B.3 essential proteasome (alpha subunit) PrcA KEEP 2369726..2370601 2369726 2370601 - 291 15609247 prcB Rv2110c COG0638O II.B.3 essential proteasome (beta subunit) PrcB KEEP 2370598..2370792 2370598 2370792 - 64 15609248 - Rv2111c - V essential hypothetical protein KEEP 2370793..2370904 2370793 2370904 I NA NA IG2142_Rv2111c-Rv2112c KEEP 2370905..2372569 2370905 2372429 - 554 15609249 - Rv2112c - V nonessential hypothetical protein KEEP 2370905..2372569 2372430 2372565 - 554 15609249 - Rv2112c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2370905..2372569 2372566 2372569 - 554 15609249 - Rv2112c - V nonessential hypothetical protein KEEP 2372570..2372629 2372570 2372629 I NA NA IG2143_Rv2112c-Rv2113 KEEP 2372630..2373823 2372630 2373823 + 397 15609250 - Rv2113 - II.C.5 nonessential integral membrane protein KEEP 2373824..2373833 2373824 2373833 I NA NA IG2144_Rv2113-Rv2114 KEEP 2373834..2374457 2373834 2374457 + 207 15609251 - Rv2114 - VI nonessential hypothetical protein KEEP 2374458..2374460 2374458 2374460 I NA NA IG2145_Rv2114-Rv2115c KEEP 2374461..2376290 2374461 2376290 - 609 15609252 - Rv2115c COG0464O III.C nonessential ATPase KEEP 2376291..2376570 2376291 2376570 I NA NA IG2146_Rv2115c-Rv2116 KEEP 2376571..2377140 2376571 2377140 + 189 15609253 lppK Rv2116 - II.C.1 nonessential lipoprotein lppK KEEP 2377141..2377147 2377141 2377147 I NA NA IG2147_Rv2116-Rv2117 KEEP 2377148..2377441 2377148 2377441 + 97 15609254 - Rv2117 COG1550S V nonessential hypothetical protein KEEP 2377442..2377469 2377442 2377469 I NA NA IG2148_Rv2117-Rv2118c KEEP 2377470..2378312 2377470 2378312 - 280 15609255 - Rv2118c COG2519J IV.H nonessential RNA methyltransferase KEEP 2378313..2378385 2378313 2378385 I NA NA IG2149_Rv2118c-Rv2119 KEEP 2378386..2379222 2378386 2379222 + 278 15609256 - Rv2119 COG2887L V nonessential hypothetical protein KEEP 2379223..2379244 2379223 2379244 I NA NA IG2150_Rv2119-Rv2120c KEEP 2379245..2379727 2379245 2379727 - 160 15609257 - Rv2120c COG3918S II.C.5 nonessential integral membrane protein KEEP 2379728..2379805 2379728 2379805 I NA NA IG2151_Rv2120c-Rv2121c KEEP 2379806..2380660 2379806 2380216 - 284 15609258 hisG Rv2121c COG0040E I.D.5 essential ATP phosphoribosyltransferase KEEP 2379806..2380660 2380217 2380261 - 284 15609258 hisG Rv2121c COG0040E I.D.5 essential ATP phosphoribosyltransferase Only Marin et al 2022 KEEP 2379806..2380660 2380262 2380660 - 284 15609258 hisG Rv2121c COG0040E I.D.5 essential ATP phosphoribosyltransferase KEEP 2380661..2380662 2380661 2380662 I NA NA IG2152_Rv2121c-Rv2122c KEEP 2380663..2380944 2380663 2380944 - 93 57116947 hisE Rv2122c COG0140E I.D.5 essential phosphoribosyl-ATP pyrophosphatase KEEP 2380945..2381070 2380945 2381070 I NA NA IG2153_Rv2122c-Rv2123 KEEP 2381071..2382492 2381071 2381445 + 473 57116948 PPE37 Rv2123 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2381071..2382492 2381446 2381513 + 473 57116948 PPE37 Rv2123 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2381071..2382492 2381514 2382492 + 473 57116948 PPE37 Rv2123 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2382489..2386067 2382489 2386067 - 1192 15609261 metH Rv2124c COG0646E,COG1410E I.D.2 nonessential 5-methyltetrahydrofolate--homocystein methyltransferase KEEP 2386068..2386292 2386068 2386292 I NA NA IG2155_Rv2124c-Rv2125 KEEP 2386293..2387171 2386293 2387171 + 292 15609262 - Rv2125 COG1938R V nonessential hypothetical protein KEEP 2387172..2387201 2387172 2387201 I NA NA IG2156_Rv2125-Rv2126c KEEP 2387202..2387972 2387202 2387280 - 256 57116949 PE_PGRS37 Rv2126c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2387202..2387972 2387281 2387659 - 256 57116949 PE_PGRS37 Rv2126c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2387202..2387972 2387660 2387972 - 256 57116949 PE_PGRS37 Rv2126c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2387973..2388615 2387973 2388615 I NA NA IG2157_Rv2126c-Rv2127 KEEP 2388616..2390085 2388616 2390085 + 489 57116950 ansP1 Rv2127 COG1113E III.A.1 nonessential L-asparagine permease ansP1 KEEP 2390085..2390288 2390085 2390288 + 67 15609265 - Rv2128 - II.C.5 nonessential transmembrane protein KEEP 2390289..2390307 2390289 2390307 I NA NA IG2159_Rv2128-Rv2129c KEEP 2390308..2391189 2390308 2391189 - 293 15609266 - Rv2129c COG1028IQR I.B.7 nonessential short chain dehydrogenase KEEP 2391190..2391214 2391190 2391214 I NA NA IG2160_Rv2129c-Rv2130c KEEP 2391215..2392459 2391215 2392459 - 414 15609267 cysS Rv2130c COG0215J II.A.3 essential cysteinyl-tRNA synthetase KEEP 2392460..2392516 2392460 2392516 I NA NA IG2161_Rv2130c-Rv2131c KEEP 2392517..2393320 2392517 2393320 - 267 15609268 cysQ Rv2131c COG1218P I.C.5 nonessential monophosphatase CysQ KEEP 2393321..2393410 2393321 2393410 I NA NA IG2162_Rv2131c-Rv2132 KEEP 2393411..2393641 2393411 2393641 + 76 15609269 - Rv2132 - V nonessential hypothetical protein KEEP 2393642..2393850 2393642 2393850 I NA NA IG2163_Rv2132-Rv2133c KEEP 2393851..2394639 2393851 2394639 - 262 15609270 - Rv2133c - V nonessential hypothetical protein KEEP 2394640..2394649 2394640 2394649 I NA NA IG2164_Rv2133c-Rv2134c KEEP 2394650..2395237 2394650 2395237 - 195 15609271 - Rv2134c - V nonessential hypothetical protein KEEP 2395238..2395300 2395238 2395300 I NA NA IG2165_Rv2134c-Rv2135c KEEP 2395301..2396011 2395301 2396011 - 236 15609272 - Rv2135c COG0406G V nonessential hypothetical protein KEEP 2396008..2396838 2396008 2396838 - 276 15609273 uppP Rv2136c COG1968V III.A.6 nonessential undecaprenyl pyrophosphate phosphatase KEEP 2396839..2396901 2396839 2396901 I NA NA IG2167_Rv2136c-Rv2137c KEEP 2396902..2397315 2396902 2397315 - 137 15609274 - Rv2137c - V nonessential hypothetical protein KEEP 2397316..2397329 2397316 2397329 I NA NA IG2168_Rv2137c-Rv2138 KEEP 2397330..2398406 2397330 2398406 + 358 15609275 lppL Rv2138 - II.C.1 essential lipoprotein LppL KEEP 2398407..2398719 2398407 2398719 I NA NA IG2169_Rv2138-Rv2139 KEEP 2398720..2399793 2398720 2399793 + 357 15609276 pyrD Rv2139 COG0167F I.F.2 nonessential dihydroorotate dehydrogenase 2 KEEP 2399794..2399797 2399794 2399797 I NA NA IG2170_Rv2139-Rv2140c KEEP 2399798..2400328 2399798 2400328 - 176 15609277 TB18.6 Rv2140c COG1881R V nonessential hypothetical protein KEEP 2400329..2400375 2400329 2400375 I NA NA IG2171_Rv2140c-Rv2141c KEEP 2400376..2401722 2400376 2401722 - 448 57116951 - Rv2141c COG0624E I.D.2 nonessential hypothetical protein KEEP 2401723..2402192 2401723 2401812 I NA NA IG2172_Rv2141c-Rv2142c KEEP 2401723..2402192 2401813 2401936 I NA NA IG2172_Rv2141c-Rv2142c Only Marin et al 2022 KEEP 2401723..2402192 2401937 2402192 I NA NA IG2172_Rv2141c-Rv2142c KEEP 2402193..2402510 2402193 2402510 - 105 15609279 - Rv2142c - VI nonessential hypothetical protein KEEP 2402511..2402976 2402511 2402976 I NA NA IG2173_Rv2142c-Rv2143 KEEP 2402977..2404035 2402977 2404035 + 352 15609280 - Rv2143 COG1926R V nonessential hypothetical protein KEEP 2404036..2404164 2404036 2404164 I NA NA IG2174_Rv2143-Rv2144c KEEP 2404165..2404521 2404165 2404521 - 118 15609281 - Rv2144c - II.C.5 nonessential transmembrane protein KEEP 2404522..2404615 2404522 2404615 I NA NA IG2175_Rv2144c-Rv2145c KEEP 2404616..2405398 2404616 2405398 - 260 15609282 wag31 Rv2145c COG3599D II.C.2 essential hypothetical protein KEEP 2405399..2405665 2405399 2405665 I NA NA IG2176_Rv2145c-Rv2146c KEEP 2405666..2405956 2405666 2405956 - 96 15609283 - Rv2146c COG0762S II.C.5 nonessential transmembrane protein KEEP 2405957..2406117 2405957 2406117 I NA NA IG2177_Rv2146c-Rv2147c KEEP 2406118..2406843 2406118 2406843 - 241 15609284 - Rv2147c COG1799S V nonessential hypothetical protein KEEP 2406840..2407616 2406840 2407616 - 258 15609285 - Rv2148c COG0325R V nonessential hypothetical protein KEEP 2407617..2407621 2407617 2407621 I NA NA IG2179_Rv2148c-Rv2149c KEEP 2407622..2408374 2407622 2408374 - 250 15609286 yfiH Rv2149c COG1496S V nonessential hypothetical protein KEEP 2408375..2408384 2408375 2408384 I NA NA IG2180_Rv2149c-Rv2150c KEEP 2408385..2409524 2408385 2409524 - 379 15609287 ftsZ Rv2150c COG0206D III.C essential cell division protein FtsZ KEEP 2409525..2409696 2409525 2409696 I NA NA IG2181_Rv2150c-Rv2151c KEEP 2409697..2410641 2409697 2410641 - 314 15609288 ftsQ Rv2151c COG1589M III.C essential cell division protein FtsQ KEEP 2410638..2412122 2410638 2412122 - 494 15609289 murC Rv2152c COG0773M II.C.3 essential UDP-N-acetylmuramate--L-alanine ligase KEEP 2412119..2413351 2412119 2413351 - 410 15609290 murG Rv2153c COG0707M II.C.3 essential N-acetylglucosaminyl transferase KEEP 2413348..2414922 2413348 2414922 - 524 15609291 ftsW Rv2154c COG0772D III.C essential FtsW-like protein FtsW KEEP 2414923..2414933 2414923 2414933 I NA NA IG2185_Rv2154c-Rv2155c KEEP 2414934..2416394 2414934 2416394 - 486 15609292 murD Rv2155c COG0771M II.C.3 essential UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase KEEP 2416396..2417475 2416396 2417475 - 359 15609293 mraY Rv2156c COG0472M II.C.3 essential phospho-N-acetylmuramoyl-pentapeptide-transferase KEEP 2417472..2419004 2417472 2419004 - 510 15609294 murF Rv2157c COG0770M II.C.3 essential UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate- D-alanyl-D-alanyl ligase MurF KEEP 2419001..2420608 2419001 2420608 - 535 15609295 murE Rv2158c COG0769M II.C.3 nonessential UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase KEEP 2420609..2420630 2420609 2420630 I NA NA IG2189_Rv2158c-Rv2159c KEEP 2420631..2421665 2420631 2421665 - 344 15609296 - Rv2159c - V nonessential hypothetical protein KEEP 2421643..2422278 2421643 2422278 - 211 57116952 - Rv2160A COG1309K V nonessential hypothetical protein KEEP 2421662..2422003 2421662 2422003 - 113 15609297 - Rv2160c - V nonessential hypothetical protein KEEP 2422004..2422270 2422004 2422270 I NA NA IG2192_Rv2160c-Rv2161c KEEP 2422271..2423137 2422271 2423137 - 288 15609298 - Rv2161c COG2141C V nonessential hypothetical protein KEEP 2423138..2423239 2423138 2423239 I NA NA IG2193_Rv2161c-Rv2162c KEEP 2423240..2424838 2423240 2423327 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2423240..2424838 2423328 2423387 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2423240..2424838 2423388 2423423 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2423240..2424838 2423424 2423425 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2423240..2424838 2423426 2423525 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2423240..2424838 2423526 2423687 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2423240..2424838 2423688 2423704 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2423240..2424838 2423705 2423775 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2423240..2424838 2423776 2423788 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + homoplasy analysis DISCARD 2423240..2424838 2423789 2424293 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2423240..2424838 2424294 2424482 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2423240..2424838 2424483 2424537 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2423240..2424838 2424538 2424838 - 532 57116953 PE_PGRS38 Rv2162c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2424839..2425047 2424839 2425047 I NA NA IG2194_Rv2162c-Rv2163c KEEP 2425048..2427087 2425048 2427087 - 679 15609300 pbpB Rv2163c COG0768M II.C.3 essential penicillin-binding membrane protein pbpB KEEP 2427084..2428238 2427084 2428238 - 384 15609301 - Rv2164c - II.C.5 essential hypothetical protein KEEP 2428235..2429269 2428235 2429269 - 344 161352465 mraW Rv2165c COG0275M V essential S-adenosyl-methyltransferase MraW KEEP 2429270..2429426 2429270 2429426 I NA NA IG2197_Rv2165c-Rv2166c KEEP 2429427..2429858 2429427 2429858 - 143 15609303 - Rv2166c COG2001S V essential cell division protein MraZ KEEP 2429859..2430158 2429859 2430106 I NA NA IG2198_Rv2166c-Rv2167c KEEP 2429859..2430158 2430107 2430158 I NA NA IG2198_Rv2166c-Rv2167c Annotation + Marin et al 2022 DISCARD 2430159..2431199 2430159 2431199 - 346 15609304 - Rv2167c COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2431094..2431420 2431094 2431420 - 108 15609305 - Rv2168c COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2431421..2431564 2431421 2431481 I NA NA IG2200_Rv2168c-Rv2169c Annotation + Marin et al 2022 DISCARD 2431421..2431564 2431482 2431564 I NA NA IG2200_Rv2168c-Rv2169c KEEP 2431565..2431969 2431565 2431969 - 134 15609306 - Rv2169c - II.C.5 nonessential transmembrane protein KEEP 2431970..2432234 2431970 2432234 I NA NA IG2201_Rv2169c-Rv2170 KEEP 2432235..2432855 2432235 2432855 + 206 15609307 - Rv2170 COG0456R V nonessential hypothetical protein KEEP 2432856..2432950 2432856 2432950 I NA NA IG2202_Rv2170-Rv2171 KEEP 2432951..2433634 2432951 2433634 + 227 15609308 lppM Rv2171 - II.C.1 nonessential lipoprotein lppM KEEP 2433631..2434536 2433631 2434536 - 301 15609309 - Rv2172c - V nonessential hypothetical protein KEEP 2434537..2434846 2434537 2434846 I NA NA IG2204_Rv2172c-Rv2173 KEEP 2434847..2435905 2434847 2435905 + 352 15609310 idsA2 Rv2173 COG0142H I.G.11 nonessential geranylgeranyl pyrophosphate synthetase KEEP 2435906..2435908 2435906 2435908 I NA NA IG2205_Rv2173-Rv2174 KEEP 2435909..2437459 2435909 2437459 + 516 15609311 - Rv2174 - II.C.5 essential integral membrane protein KEEP 2437446..2437886 2437446 2437886 - 146 15609312 - Rv2175c - I.J.1 nonessential putative regulatory protein KEEP 2437887..2437940 2437887 2437940 I NA NA IG2207_Rv2175c-Rv2176 KEEP 2437941..2439140 2437941 2439140 + 399 15609313 pknL Rv2176 COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase L KEEP 2439141..2439281 2439141 2439176 I NA NA IG2208_Rv2176-Rv2177c KEEP 2439141..2439281 2439177 2439281 I NA NA IG2208_Rv2176-Rv2177c Annotation + Marin et al 2022 DISCARD 2439282..2439947 2439282 2439947 - 221 15609314 - Rv2177c COG3547L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2439948..2440331 2439948 2439954 I NA NA IG2209_Rv2177c-Rv2178c Annotation + Marin et al 2022 DISCARD 2439948..2440331 2439955 2440278 I NA NA IG2209_Rv2177c-Rv2178c KEEP 2439948..2440331 2440279 2440331 I NA NA IG2209_Rv2177c-Rv2178c Annotation + Marin et al 2022 DISCARD 2440332..2441720 2440332 2440334 - 462 15609315 aroG Rv2178c COG3200E I.D.4 essential 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG Only Marin et al 2022 KEEP 2440332..2441720 2440335 2441720 - 462 15609315 aroG Rv2178c COG3200E I.D.4 essential 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG KEEP 2441721..2441810 2441721 2441810 I NA NA IG2210_Rv2178c-Rv2179c KEEP 2441811..2442317 2441811 2442317 - 168 15609316 - Rv2179c - V essential hypothetical protein KEEP 2442318..2442326 2442318 2442326 I NA NA IG2211_Rv2179c-Rv2180c KEEP 2442327..2443214 2442327 2443214 - 295 15609317 - Rv2180c - II.C.5 nonessential integral membrane protein KEEP 2443215..2443301 2443215 2443301 I NA NA IG2212_Rv2180c-Rv2181 KEEP 2443302..2444585 2443302 2444585 + 427 15609318 - Rv2181 - II.C.5 nonessential integral membrane protein KEEP 2444586..2445329 2444586 2445329 - 247 15609319 - Rv2182c COG0204I IV.H essential 1-acylglycerol-3-phosphate O-acyltransferase KEEP 2445330..2445414 2445330 2445414 I NA NA IG2214_Rv2182c-Rv2183c KEEP 2445415..2445810 2445415 2445810 - 131 15609320 - Rv2183c - V nonessential hypothetical protein KEEP 2445807..2446946 2445807 2446946 - 379 15609321 - Rv2184c COG0003P V nonessential hypothetical protein KEEP 2446947..2447065 2446947 2447065 I NA NA IG2216_Rv2184c-Rv2185c KEEP 2447066..2447500 2447066 2447500 - 144 15609322 TB16.3 Rv2185c - V nonessential hypothetical protein KEEP 2447501..2447604 2447501 2447604 I NA NA IG2217_Rv2185c-Rv2186c KEEP 2447605..2447994 2447605 2447994 - 129 15609323 - Rv2186c - V nonessential hypothetical protein KEEP 2447995..2448159 2447995 2448159 I NA NA IG2218_Rv2186c-Rv2187 KEEP 2448160..2449962 2448160 2449218 + 600 15609324 fadD15 Rv2187 COG1022I I.A.3 nonessential long-chain-fatty-acid-CoA ligase fadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) KEEP 2448160..2449962 2449219 2449221 + 600 15609324 fadD15 Rv2187 COG1022I I.A.3 nonessential long-chain-fatty-acid-CoA ligase fadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Only Marin et al 2022 KEEP 2448160..2449962 2449222 2449962 + 600 15609324 fadD15 Rv2187 COG1022I I.A.3 nonessential long-chain-fatty-acid-CoA ligase fadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) KEEP 2449963..2449992 2449963 2449992 I NA NA IG2219_Rv2187-Rv2188c KEEP 2449993..2451150 2449993 2451150 - 385 57116954 - Rv2188c COG0438M V essential hypothetical protein KEEP 2451151..2451246 2451151 2451246 I NA NA IG2220_Rv2188c-Rv2189c KEEP 2451247..2452020 2451247 2452020 - 257 15609326 - Rv2189c - V nonessential hypothetical protein KEEP 2452021..2452114 2452021 2452114 I NA NA IG2221_Rv2189c-Rv2190c KEEP 2452115..2453272 2452115 2453272 - 385 15609327 - Rv2190c COG0791M IV.A nonessential hypothetical protein KEEP 2453273..2453818 2453273 2453818 I NA NA IG2222_Rv2190c-Rv2191 KEEP 2453819..2455756 2453819 2455756 + 645 15609328 - Rv2191 COG0322L,COG0847L II.A.5 nonessential hypothetical protein KEEP 2455631..2456743 2455631 2456743 - 370 15609329 trpD Rv2192c COG0547E I.D.4 essential anthranilate phosphoribosyltransferase KEEP 2456744..2456900 2456744 2456900 I NA NA IG2224_Rv2192c-Rv2193 KEEP 2456901..2457512 2456901 2457512 + 203 15609330 ctaE Rv2193 COG1845C I.B.6a essential cytochrome C oxidase subunit III KEEP 2457513..2457552 2457513 2457552 I NA NA IG2225_Rv2193-Rv2194 KEEP 2457553..2458395 2457553 2458390 + 280 15609331 qcrC Rv2194 COG2010C I.B.6a essential ubiquinol-cytochrome C reductase QcrC(cytochrome C subunit) KEEP 2457553..2458395 2458391 2458395 + 280 15609331 qcrC Rv2194 COG2010C I.B.6a essential ubiquinol-cytochrome C reductase QcrC(cytochrome C subunit) Only Marin et al 2022 KEEP 2458392..2459681 2458392 2458471 + 429 15609332 qcrA Rv2195 COG0723C I.B.6a essential Rieske iron-sulfur protein QcrA Only Marin et al 2022 KEEP 2458392..2459681 2458472 2459681 + 429 15609332 qcrA Rv2195 COG0723C I.B.6a essential Rieske iron-sulfur protein QcrA KEEP 2459678..2461327 2459678 2461321 + 549 15609333 qcrB Rv2196 COG1290C I.B.6a essential ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) KEEP 2459678..2461327 2461322 2461327 + 549 15609333 qcrB Rv2196 COG1290C I.B.6a essential ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) Only Marin et al 2022 KEEP 2461328..2461503 2461328 2461503 I NA NA IG2228_Rv2196-Rv2197c Only Marin et al 2022 KEEP 2461504..2462148 2461504 2461510 - 214 15609334 - Rv2197c - II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2461504..2462148 2461511 2462148 - 214 15609334 - Rv2197c - II.C.5 nonessential transmembrane protein KEEP 2462148..2463047 2462148 2462527 - 299 15609335 mmpS3 Rv2198c - II.C.4 nonessential membrane protein KEEP 2462148..2463047 2462528 2462594 - 299 15609335 mmpS3 Rv2198c - II.C.4 nonessential membrane protein Only Marin et al 2022 KEEP 2462148..2463047 2462595 2463047 - 299 15609335 mmpS3 Rv2198c - II.C.4 nonessential membrane protein KEEP 2463048..2463232 2463048 2463232 I NA NA IG2230_Rv2198c-Rv2199c KEEP 2463233..2463652 2463233 2463652 - 139 15609336 - Rv2199c - II.C.5 nonessential integral membrane protein KEEP 2463653..2463659 2463653 2463659 I NA NA IG2231_Rv2199c-Rv2200c KEEP 2463660..2464751 2463660 2464751 - 363 15609337 ctaC Rv2200c COG1622C I.B.6a essential transmembrane cytochrome C oxidase subunit II CtaC KEEP 2464752..2464996 2464752 2464996 I NA NA IG2232_Rv2200c-Rv2201 KEEP 2464997..2466955 2464997 2466955 + 652 15609338 asnB Rv2201 COG0367E I.D.2 essential asparagine synthetase AsnB KEEP 2466956..2467052 2466956 2466994 I NA NA IG2233_Rv2201-Rv2202c KEEP 2466956..2467052 2466995 2467029 I NA NA IG2233_Rv2201-Rv2202c Only Marin et al 2022 KEEP 2466956..2467052 2467030 2467052 I NA NA IG2233_Rv2201-Rv2202c KEEP 2467053..2468027 2467053 2468027 - 324 15609339 cbhK Rv2202c COG0524G I.A.1 nonessential carbohydrate kinase CbhK KEEP 2468028..2468230 2468028 2468230 I NA NA IG2234_Rv2202c-Rv2203 KEEP 2468231..2468923 2468231 2468923 + 230 15609340 - Rv2203 - II.C.5 nonessential hypothetical protein KEEP 2468924..2468930 2468924 2468930 I NA NA IG2235_Rv2203-Rv2204c KEEP 2468931..2469287 2468931 2469287 - 118 15609341 - Rv2204c COG0316S V nonessential hypothetical protein KEEP 2469288..2469386 2469288 2469386 I NA NA IG2236_Rv2204c-Rv2205c KEEP 2469387..2470463 2469387 2470042 - 358 57116955 - Rv2205c COG1929G V nonessential hypothetical protein KEEP 2469387..2470463 2470043 2470086 - 358 57116955 - Rv2205c COG1929G V nonessential hypothetical protein Only Marin et al 2022 KEEP 2469387..2470463 2470087 2470463 - 358 57116955 - Rv2205c COG1929G V nonessential hypothetical protein KEEP 2470464..2470621 2470464 2470621 I NA NA IG2237_Rv2205c-Rv2206 KEEP 2470622..2471332 2470622 2471332 + 236 57116956 - Rv2206 - II.C.5 nonessential transmembrane protein KEEP 2471333..2471410 2471333 2471410 I NA NA IG2238_Rv2206-Rv2207 KEEP 2471411..2472496 2471411 2472496 + 361 15609344 cobT Rv2207 COG2038H I.G.13 nonessential nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase KEEP 2472493..2473242 2472493 2473242 + 249 15609345 cobS Rv2208 COG0368H I.G.13 nonessential cobalamin synthase KEEP 2473243..2473399 2473243 2473399 I NA NA IG2240_Rv2208-Rv2209 KEEP 2473400..2474938 2473400 2474938 + 512 15609346 - Rv2209 - III.A.6 nonessential integral membrane protein KEEP 2474864..2475970 2474864 2475970 - 368 15609347 ilvE Rv2210c COG0115EH I.D.7 essential branched-chain amino acid aminotransferase KEEP 2475971..2476041 2475971 2476041 I NA NA IG2242_Rv2210c-Rv2211c KEEP 2476042..2477181 2476042 2477181 - 379 15609348 gcvT Rv2211c COG0404E I.C.1 essential glycine cleavage system aminomethyltransferase T KEEP 2477182..2477189 2477182 2477189 I NA NA IG2243_Rv2211c-Rv2212 KEEP 2477190..2478326 2477190 2478326 + 378 15609349 - Rv2212 COG2114T V nonessential hypothetical protein KEEP 2478327..2478337 2478327 2478337 I NA NA IG2244_Rv2212-Rv2213 KEEP 2478338..2479885 2478338 2479885 + 515 15609350 pepB Rv2213 COG0260E II.B.3 nonessential leucyl aminopeptidase KEEP 2479886..2479922 2479886 2479922 I NA NA IG2245_Rv2213-Rv2214c KEEP 2479923..2481701 2479923 2481701 - 592 15609351 ephD Rv2214c COG0596R,COG1028IQR III.F nonessential short chain dehydrogenase KEEP 2481702..2481964 2481702 2481964 I NA NA IG2246_Rv2214c-Rv2215 KEEP 2481965..2483626 2481965 2482060 + 553 15609352 dlaT Rv2215 COG0508C I.B.3 essential dihydrolipoamide acetyltransferase KEEP 2481965..2483626 2482061 2482111 + 553 15609352 dlaT Rv2215 COG0508C I.B.3 essential dihydrolipoamide acetyltransferase Only Marin et al 2022 KEEP 2481965..2483626 2482112 2482417 + 553 15609352 dlaT Rv2215 COG0508C I.B.3 essential dihydrolipoamide acetyltransferase KEEP 2481965..2483626 2482418 2482468 + 553 15609352 dlaT Rv2215 COG0508C I.B.3 essential dihydrolipoamide acetyltransferase Only Marin et al 2022 KEEP 2481965..2483626 2482469 2483626 + 553 15609352 dlaT Rv2215 COG0508C I.B.3 essential dihydrolipoamide acetyltransferase KEEP 2483626..2484531 2483626 2484531 + 301 15609353 - Rv2216 COG1090R V nonessential hypothetical protein KEEP 2484532..2484583 2484532 2484583 I NA NA IG2248_Rv2216-Rv2217 KEEP 2484584..2485276 2484584 2485276 + 230 15609354 lipB Rv2217 COG0321H I.G.3 essential lipoyltransferase KEEP 2485273..2486208 2485273 2486208 + 311 15609355 lipA Rv2218 COG0320H I.G.3 essential lipoyl synthase KEEP 2486209..2486234 2486209 2486234 I NA NA IG2250_Rv2218-Rv2219 KEEP 2486235..2486987 2486235 2486987 + 250 15609356 - Rv2219 - II.C.5 essential transmembrane protein KEEP 2486988..2486993 2486988 2486993 I NA NA IG2251_Rv2219-Rv2219A KEEP 2486994..2487416 2486994 2487416 - 140 57116957 - Rv2219A - II.C.4 nonessential hypothetical protein KEEP 2487417..2487614 2487417 2487614 I NA NA IG2252_Rv2219A-Rv2220 KEEP 2487615..2489051 2487615 2489051 + 478 15609357 glnA1 Rv2220 COG0174E I.D.1 essential glutamine synthetase GLNA1 (glutamine synthase) (GS-I) KEEP 2489052..2489368 2489052 2489368 I NA NA IG2253_Rv2220-Rv2221c KEEP 2489369..2492353 2489369 2492353 - 994 15609358 glnE Rv2221c COG1391OT I.D.1 essential glutamate-ammonia-ligase adenylyltransferase GLNE (glutamine-synthetase adenylyltransferase) KEEP 2492354..2492401 2492354 2492401 I NA NA IG2254_Rv2221c-Rv2222c KEEP 2492402..2493742 2492402 2493742 - 446 15609359 glnA2 Rv2222c COG0174E I.D.1 nonessential glutamine synthetase KEEP 2493743..2493836 2493743 2493836 I NA NA IG2255_Rv2222c-Rv2223c KEEP 2493837..2495399 2493837 2495399 - 520 15609360 - Rv2223c COG0596R II.C.2 nonessential exported protease KEEP 2495400..2495460 2495400 2495460 I NA NA IG2256_Rv2223c-Rv2224c KEEP 2495461..2497023 2495461 2497023 - 520 15609361 - Rv2224c COG0596R II.C.2 essential exported protease KEEP 2497024..2497741 2497024 2497741 I NA NA IG2257_Rv2224c-Rv2225 KEEP 2497742..2498587 2497742 2498587 + 281 15609362 panB Rv2225 COG0413H I.G.5 essential 3-methyl-2-oxobutanoate hydroxymethyltransferase KEEP 2498588..2498831 2498588 2498831 I NA NA IG2258_Rv2225-Rv2226 KEEP 2498832..2500373 2498832 2500373 + 513 15609363 - Rv2226 COG5607S V nonessential hypothetical protein KEEP 2500374..2500930 2500374 2500930 I NA NA IG2259_Rv2226-Rv2227 KEEP 2500931..2501632 2500931 2501632 + 233 15609364 - Rv2227 COG3826S V nonessential hypothetical protein KEEP 2501633..2501643 2501633 2501643 I NA NA IG2260_Rv2227-Rv2228c KEEP 2501644..2502738 2501644 2502738 - 364 15609365 - Rv2228c COG0328L,COG0406G V nonessential bifunctional RNase H/acid phosphatase KEEP 2502735..2503472 2502735 2503472 - 245 15609366 - Rv2229c COG1579R V essential hypothetical protein KEEP 2503469..2504608 2503469 2504608 - 379 15609367 - Rv2230c COG0327S,COG3323S V nonessential hypothetical protein KEEP 2504605..2505699 2504605 2505699 - 364 15609368 cobC Rv2231c COG0079E I.G.13 essential hypothetical protein KEEP 2505700..2506277 2505700 2506277 I NA NA IG2264_Rv2231c-Rv2232 KEEP 2506278..2507153 2506278 2507153 + 291 57116958 - Rv2232 COG0546R V nonessential hypothetical protein KEEP 2507146..2507637 2507146 2507637 + 163 15609371 ptpA Rv2234 COG0394T I.J.3 nonessential phosphotyrosine protein phosphatase PTPA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) KEEP 2507637..2508452 2507637 2508452 + 271 15609372 - Rv2235 COG3346S II.C.5 essential transmembrane protein KEEP 2508434..2509375 2508434 2509375 - 313 15609373 cobD Rv2236c COG1270H I.G.13 nonessential cobalamin biosynthesis protein KEEP 2509376..2509488 2509376 2509488 I NA NA IG2268_Rv2236c-Rv2237 KEEP 2509489..2510256 2509489 2510256 + 255 15609374 - Rv2237 COG3662S V nonessential hypothetical protein KEEP 2510257..2510714 2510257 2510714 I NA NA IG2269_Rv2237-Rv2238c KEEP 2510715..2511176 2510715 2511176 - 153 15609375 ahpE Rv2238c COG1225O III.F nonessential peroxiredoxin AhpE KEEP 2511176..2511652 2511176 2511652 - 158 15609376 - Rv2239c - V nonessential hypothetical protein KEEP 2511653..2511689 2511653 2511689 I NA NA IG2271_Rv2239c-Rv2240c KEEP 2511690..2512487 2511690 2512487 - 265 15609377 - Rv2240c - VI nonessential hypothetical protein KEEP 2512488..2512538 2512488 2512538 I NA NA IG2272_Rv2240c-Rv2241 KEEP 2512539..2515244 2512539 2515244 + 901 15609378 aceE Rv2241 COG2609C I.B.2 essential pyruvate dehydrogenase subunit E1 KEEP 2515245..2515303 2515245 2515303 I NA NA IG2273_Rv2241-Rv2242 KEEP 2515304..2516548 2515304 2516548 + 414 15609379 - Rv2242 COG2508TQ V DR-inh essential hypothetical protein KEEP 2516549..2516786 2516549 2516786 I NA NA IG2274_Rv2242-Rv2243 KEEP 2516787..2517695 2516787 2517695 + 302 15609380 fabD Rv2243 COG0331I I.H.1 DR-inh nonessential acyl-carrier-protein S-malonyltransferase KEEP 2517696..2517770 2517696 2517770 I NA NA IG2275_Rv2243-Rv2244 KEEP 2517771..2518118 2517771 2518118 + 115 15609381 acpP Rv2244 COG0236IQ I.H.1 essential acyl carrier protein KEEP 2518115..2519365 2518115 2519365 + 416 15609382 kasA Rv2245 COG0304IQ I.H.1 DR-inh essential 3-oxoacyl-(acyl carrier protein) synthase II KEEP 2519366..2519395 2519366 2519395 I NA NA IG2277_Rv2245-Rv2246 KEEP 2519396..2520712 2519396 2520712 + 438 15609383 kasB Rv2246 COG0304IQ I.H.1 essential 3-oxoacyl-(acyl carrier protein) synthase II KEEP 2520713..2520742 2520713 2520742 I NA NA IG2278_Rv2246-Rv2247 KEEP 2520743..2522164 2520743 2522164 + 473 15609384 accD6 Rv2247 COG4799I I.H.1 DR-inh essential acetyl/propionyl-CoA carboxylase beta subunit AccD6 KEEP 2522165..2522359 2522165 2522185 I NA NA IG2279_Rv2247-Rv2248 KEEP 2522165..2522359 2522186 2522192 I NA NA IG2279_Rv2247-Rv2248 Only Marin et al 2022 KEEP 2522165..2522359 2522193 2522193 I NA NA IG2279_Rv2247-Rv2248 KEEP 2522165..2522359 2522194 2522219 I NA NA IG2279_Rv2247-Rv2248 Only Marin et al 2022 KEEP 2522165..2522359 2522220 2522359 I NA NA IG2279_Rv2247-Rv2248 KEEP 2522360..2523175 2522360 2523175 + 271 15609385 - Rv2248 - V nonessential hypothetical protein KEEP 2523176..2523240 2523176 2523181 I NA NA IG2280_Rv2248-Rv2249c KEEP 2523176..2523240 2523182 2523239 I NA NA IG2280_Rv2248-Rv2249c Only Marin et al 2022 KEEP 2523176..2523240 2523240 2523240 I NA NA IG2280_Rv2248-Rv2249c KEEP 2523241..2524791 2523241 2524791 - 516 15609386 glpD1 Rv2249c COG0578C I.B.6a nonessential glycerol-3-phosphate dehydrogenase KEEP 2524785..2525354 2524785 2525354 - 189 57116959 - Rv2250c COG1309K VII nonessential transcriptional regulator KEEP 2525355..2525401 2525355 2525401 I NA NA IG2282_Rv2250c-Rv2250A KEEP 2525402..2525821 2525402 2525821 + 139 57116960 - Rv2250A COG0277C I.J.1 nonessential flavoprotein KEEP 2525565..2526992 2525565 2526992 + 475 15609388 - Rv2251 COG0277C VII essential flavoprotein KEEP 2526989..2527918 2526989 2527918 + 309 15609389 - Rv2252 COG1597IR V nonessential diacylglycerol kinase KEEP 2527919..2527983 2527919 2527983 I NA NA IG2285_Rv2252-Rv2253 KEEP 2527984..2528487 2527984 2528487 + 167 15609390 - Rv2253 - VI nonessential hypothetical protein KEEP 2528488..2528519 2528488 2528519 I NA NA IG2286_Rv2253-Rv2254c KEEP 2528520..2528975 2528520 2528975 - 151 15609391 - Rv2254c - II.C.5 nonessential integral membrane protein KEEP 2528976..2528979 2528976 2528979 I NA NA IG2287_Rv2254c-Rv2255c KEEP 2528980..2529174 2528980 2529174 - 64 15609392 - Rv2255c - VI nonessential hypothetical protein KEEP 2529175..2529340 2529175 2529340 I NA NA IG2288_Rv2255c-Rv2256c KEEP 2529341..2529874 2529341 2529874 - 177 15609393 - Rv2256c - V nonessential hypothetical protein KEEP 2529875..2530003 2529875 2530003 I NA NA IG2289_Rv2256c-Rv2257c KEEP 2530004..2530822 2530004 2530822 - 272 15609394 - Rv2257c COG1680V V nonessential hypothetical protein KEEP 2530823..2530835 2530823 2530835 I NA NA IG2290_Rv2257c-Rv2258c KEEP 2530836..2531897 2530836 2531885 - 353 15609395 - Rv2258c COG0500QR I.J.1 nonessential transcriptional regulator KEEP 2530836..2531897 2531886 2531897 - 353 15609395 - Rv2258c COG0500QR I.J.1 nonessential transcriptional regulator Only Marin et al 2022 KEEP 2531898..2532244 2531898 2532244 I NA NA IG2291_Rv2258c-Rv2259 Only Marin et al 2022 KEEP 2532245..2533330 2532245 2533330 + 361 15609396 adhE2 Rv2259 COG1062C I.B.7 nonessential zinc-dependent alcohol dehydrogenase AdhE2 KEEP 2533330..2533965 2533330 2533965 + 211 15609397 - Rv2260 COG0491R V essential hypothetical protein KEEP 2533966..2534041 2533966 2534041 I NA NA IG2293_Rv2260-Rv2261c KEEP 2534042..2534464 2534042 2534464 - 140 15609398 - Rv2261c COG0815M I.H.3 nonessential hypothetical protein KEEP 2534465..2534469 2534465 2534469 I NA NA IG2294_Rv2261c-Rv2262c KEEP 2534470..2535552 2534470 2535552 - 360 15609399 - Rv2262c COG0815M I.H.3 nonessential hypothetical protein KEEP 2535553..2535640 2535553 2535640 I NA NA IG2295_Rv2262c-Rv2263 KEEP 2535641..2536594 2535641 2536594 + 317 15609400 - Rv2263 COG1028IQR I.B.7 nonessential short chain dehydrogenase KEEP 2536572..2538350 2536572 2538350 - 592 15609401 - Rv2264c COG0443O V nonessential hypothetical protein KEEP 2538351..2538699 2538351 2538699 I NA NA IG2297_Rv2264c-Rv2265 KEEP 2538700..2539929 2538700 2539929 + 409 15609402 - Rv2265 COG0477GEPR II.C.5 nonessential integral membrane protein KEEP 2539930..2540103 2539930 2540103 I NA NA IG2298_Rv2265-Rv2266 KEEP 2540104..2541390 2540104 2541390 + 428 15609403 cyp124 Rv2266 COG2124Q IV.F nonessential cytochrome P450 124 CYP124 KEEP 2541391..2541643 2541391 2541643 I NA NA IG2299_Rv2266-Rv2267c KEEP 2541644..2542810 2541644 2542810 - 388 15609404 - Rv2267c COG0457R V nonessential hypothetical protein KEEP 2542807..2544276 2542807 2544276 - 489 15609405 cyp128 Rv2268c COG2124Q IV.F essential cytochrome P450 128 KEEP 2544277..2544288 2544277 2544288 I NA NA IG2301_Rv2268c-Rv2269c KEEP 2544289..2544621 2544289 2544621 - 110 15609406 - Rv2269c - VI nonessential hypothetical protein KEEP 2544622..2544697 2544622 2544697 I NA NA IG2302_Rv2269c-Rv2270 KEEP 2544698..2545225 2544698 2545225 + 175 15609407 lppN Rv2270 - II.C.1 nonessential lipoprotein lppN KEEP 2545226..2545331 2545226 2545331 I NA NA IG2303_Rv2270-Rv2271 KEEP 2545332..2545631 2545332 2545631 + 99 15609408 - Rv2271 - V nonessential hypothetical protein KEEP 2545632..2545736 2545632 2545736 I NA NA IG2304_Rv2271-Rv2272 KEEP 2545737..2546105 2545737 2546105 + 122 15609409 - Rv2272 COG2149S II.C.5 nonessential transmembrane protein KEEP 2546102..2546431 2546102 2546431 + 109 15609410 - Rv2273 - II.C.5 nonessential transmembrane protein KEEP 2546432..2546487 2546432 2546487 I NA NA IG2306_Rv2273-Rv2274c Only Marin et al 2022 KEEP 2546488..2546805 2546488 2546497 - 105 15609411 - Rv2274c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 2546488..2546805 2546498 2546805 - 105 15609411 - Rv2274c - VI nonessential hypothetical protein KEEP 2546806..2546882 2546806 2546882 I NA NA IG2307_Rv2274c-Rv2275 KEEP 2546883..2547752 2546883 2547752 + 289 15609412 - Rv2275 - V essential hypothetical protein KEEP 2547749..2548939 2547749 2548939 + 396 15609413 cyp121 Rv2276 COG2124Q IV.F nonessential cytochrome P450 121 CYP121 KEEP 2548940..2549123 2548940 2549123 I NA NA IG2309_Rv2276-Rv2277c KEEP 2549124..2550029 2549124 2550001 - 301 15609414 - Rv2277c COG0584C VI essential glycerolphosphodiesterase KEEP 2549124..2550029 2550002 2550029 - 301 15609414 - Rv2277c COG0584C VI essential glycerolphosphodiesterase Marin et al 2022 + homoplasy analysis DISCARD 2550030..2550064 2550030 2550064 I NA NA IG2310_Rv2277c-Rv2278 Annotation + Marin et al 2022 DISCARD 2550065..2550391 2550065 2550391 + 108 15609415 - Rv2278 COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2550388..2551326 2550388 2551326 + 312 15609416 - Rv2279 COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2551327..2551559 2551327 2551378 I NA NA IG2312_Rv2279-Rv2280 Annotation + Marin et al 2022 DISCARD 2551327..2551559 2551379 2551559 I NA NA IG2312_Rv2279-Rv2280 KEEP 2551560..2552939 2551560 2552939 + 459 15609417 - Rv2280 COG0277C I.B.7 nonessential dehydrogenase KEEP 2552940..2553172 2552940 2553172 I NA NA IG2313_Rv2280-Rv2281 KEEP 2553173..2554831 2553173 2554831 + 552 15609418 pitB Rv2281 COG0306P III.A.4 nonessential phosphate ABC transporter permease KEEP 2554832..2554937 2554832 2554863 I NA NA IG2314_Rv2281-Rv2282c KEEP 2554832..2554937 2554864 2554933 I NA NA IG2314_Rv2281-Rv2282c Only Marin et al 2022 KEEP 2554832..2554937 2554934 2554937 I NA NA IG2314_Rv2281-Rv2282c KEEP 2554938..2555876 2554938 2555876 - 312 15609419 - Rv2282c COG0583K I.J.1 nonessential LysR family transcriptional regulator KEEP 2555877..2555940 2555877 2555940 I NA NA IG2315_Rv2282c-Rv2283 KEEP 2555941..2556135 2555941 2556135 + 64 15609420 - Rv2283 - VI essential hypothetical protein KEEP 2556136..2556144 2556136 2556144 I NA NA IG2316_Rv2283-Rv2284 KEEP 2556145..2557440 2556145 2557440 + 431 15609421 lipM Rv2284 COG0657I II.B.5 nonessential esterase LipM KEEP 2557441..2557472 2557441 2557472 I NA NA IG2317_Rv2284-Rv2285 KEEP 2557473..2558810 2557473 2558810 + 445 15609422 - Rv2285 - V nonessential hypothetical protein KEEP 2558811..2558876 2558811 2558876 I NA NA IG2318_Rv2285-Rv2286c KEEP 2558877..2559569 2558877 2559569 - 230 15609423 - Rv2286c COG3917Q V nonessential hypothetical protein KEEP 2559570..2559702 2559570 2559702 I NA NA IG2319_Rv2286c-Rv2287 KEEP 2559703..2561331 2559703 2561331 + 542 15609424 yjcE Rv2287 COG0025P III.A.2 nonessential integral membrane transport protein YjcE KEEP 2561328..2561705 2561328 2561705 + 125 15609425 - Rv2288 - VI nonessential hypothetical protein KEEP 2561675..2562457 2561675 2562457 + 260 15609426 cdh Rv2289 COG2134I I.H.3 nonessential CDP-diacylglycerol pyrophosphatase KEEP 2562458..2562598 2562458 2562598 I NA NA IG2322_Rv2289-Rv2290 KEEP 2562599..2563114 2562599 2563114 + 171 15609427 lppO Rv2290 - II.C.1 nonessential lipoprotein lppO KEEP 2563115..2563173 2563115 2563173 I NA NA IG2323_Rv2290-Rv2291 KEEP 2563174..2564028 2563174 2564028 + 284 15609428 sseB Rv2291 COG2897P I.C.5 nonessential thiosulfate sulfurtransferase SseB KEEP 2564029..2564253 2564029 2564253 - 74 15609429 - Rv2292c COG0775F VI nonessential hypothetical protein KEEP 2564254..2564291 2564254 2564291 I NA NA IG2325_Rv2292c-Rv2293c KEEP 2564292..2565032 2564292 2565032 - 246 15609430 - Rv2293c COG0775F V nonessential hypothetical protein KEEP 2565033..2565326 2565033 2565326 I NA NA IG2326_Rv2293c-Rv2294 KEEP 2565327..2566550 2565327 2566550 + 407 15609431 - Rv2294 COG1168E IV.H nonessential aminotransferase KEEP 2566551..2566771 2566551 2566771 I NA NA IG2327_Rv2294-Rv2295 KEEP 2566772..2567410 2566772 2567410 + 212 15609432 - Rv2295 COG3196S V nonessential hypothetical protein KEEP 2567411..2567503 2567411 2567503 I NA NA IG2328_Rv2295-Rv2296 KEEP 2567504..2568406 2567504 2568406 + 300 15609433 - Rv2296 COG0596R VII nonessential haloalkane dehalogenase KEEP 2568407..2568437 2568407 2568437 I NA NA IG2329_Rv2296-Rv2297 KEEP 2568438..2568890 2568438 2568890 + 150 15609434 - Rv2297 - VI nonessential hypothetical protein KEEP 2568891..2569081 2568891 2569081 I NA NA IG2330_Rv2297-Rv2298 KEEP 2569082..2570053 2569082 2570053 + 323 15609435 - Rv2298 COG0667C V nonessential hypothetical protein KEEP 2570054..2570058 2570054 2570058 I NA NA IG2331_Rv2298-Rv2299c KEEP 2570059..2572002 2570059 2572002 - 647 15609436 htpG Rv2299c COG0326O III.B nonessential heat shock protein 90 KEEP 2572003..2572075 2572003 2572075 I NA NA IG2332_Rv2299c-Rv2300c KEEP 2572076..2573008 2572076 2573008 - 310 15609437 - Rv2300c COG0491R V nonessential hypothetical protein KEEP 2573009..2573014 2573009 2573014 I NA NA IG2333_Rv2300c-Rv2301 KEEP 2573015..2573707 2573015 2573707 + 230 57116961 cut2 Rv2301 - II.C.2 nonessential cutinase CUT2 KEEP 2573708..2573812 2573708 2573812 I NA NA IG2334_Rv2301-Rv2302 KEEP 2573813..2574055 2573813 2574055 + 80 15609439 - Rv2302 - V nonessential hypothetical protein KEEP 2574056..2574095 2574056 2574095 I NA NA IG2335_Rv2302-Rv2303c KEEP 2574096..2575019 2574096 2575019 - 307 15609440 - Rv2303c COG2159R IV.D nonessential antibiotic-resistance protein KEEP 2575016..2575225 2575016 2575225 - 69 15609441 - Rv2304c - VI nonessential hypothetical protein KEEP 2575226..2575808 2575226 2575808 I NA NA IG2337_Rv2304c-Rv2305 KEEP 2575809..2577098 2575809 2577098 + 429 15609442 - Rv2305 - VI nonessential hypothetical protein KEEP 2577099..2577107 2577099 2577107 I NA NA IG2338_Rv2305-Rv2306A KEEP 2577108..2577701 2577108 2577284 + 197 57116962 - Rv2306A COG0398S,COG0841V II.C.5 nonessential hypothetical protein KEEP 2577108..2577701 2577285 2577362 + 197 57116962 - Rv2306A COG0398S,COG0841V II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 2577108..2577701 2577363 2577678 + 197 57116962 - Rv2306A COG0398S,COG0841V II.C.5 nonessential hypothetical protein KEEP 2577108..2577701 2577679 2577701 + 197 57116962 - Rv2306A COG0398S,COG0841V II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 2577488..2577922 2577488 2577678 + 144 57116963 - Rv2306B COG0398S II.C.5 nonessential hypothetical protein KEEP 2577488..2577922 2577679 2577732 + 144 57116963 - Rv2306B COG0398S II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 2577488..2577922 2577733 2577922 + 144 57116963 - Rv2306B COG0398S II.C.5 nonessential hypothetical protein KEEP 2577851..2578696 2577851 2578696 - 281 15609444 - Rv2307c COG1073R VI nonessential hypothetical protein KEEP 2578697..2579227 2578697 2579227 I NA NA IG2341_Rv2307c-Rv2307A KEEP 2579228..2579419 2579228 2579419 - 63 57116964 - Rv2307A - V nonessential glycine rich protein KEEP 2579420..2579503 2579420 2579503 I NA NA IG2342_Rv2307A-Rv2307B KEEP 2579504..2579935 2579504 2579935 - 143 57116965 - Rv2307B - VI nonessential glycine rich protein KEEP 2579936..2580027 2579936 2580027 I NA NA IG2343_Rv2307B-Rv2307D KEEP 2580028..2580210 2580028 2580210 - 60 57116966 - Rv2307D - VI nonessential hypothetical protein KEEP 2580211..2580418 2580211 2580418 I NA NA IG2344_Rv2307D-Rv2308 KEEP 2580419..2581135 2580419 2581135 + 238 15609445 - Rv2308 COG2442S I.J.1 nonessential hypothetical protein KEEP 2581136..2581842 2581136 2581842 I NA NA IG2345_Rv2308-Rv2309c KEEP 2581843..2582298 2581843 2582298 - 151 15609446 - Rv2309c COG0582L VI nonessential hypothetical protein KEEP 2582299..2583044 2582299 2583044 I NA NA IG2346_Rv2309c-Rv2309A KEEP 2583045..2583332 2583045 2583332 + 95 57116967 - Rv2309A - IV.B.3 nonessential hypothetical protein KEEP 2583333..2583434 2583333 2583434 I NA NA IG2347_Rv2309A-Rv2310 KEEP 2583435..2583779 2583435 2583779 + 114 15609447 - Rv2310 COG1910P IV.B.3 nonessential excisionase KEEP 2583780..2583883 2583780 2583883 I NA NA IG2348_Rv2310-Rv2311 KEEP 2583884..2584408 2583884 2584408 + 174 15609448 - Rv2311 COG0507L V nonessential hypothetical protein KEEP 2584409..2584485 2584409 2584485 I NA NA IG2349_Rv2311-Rv2312 KEEP 2584486..2584755 2584486 2584755 + 89 15609449 - Rv2312 - VI nonessential hypothetical protein KEEP 2584756..2585051 2584756 2585051 I NA NA IG2350_Rv2312-Rv2313c KEEP 2585052..2585906 2585052 2585906 - 284 15609450 - Rv2313c COG2128S VI nonessential hypothetical protein KEEP 2585907..2585916 2585907 2585916 I NA NA IG2351_Rv2313c-Rv2314c KEEP 2585917..2587290 2585917 2587290 - 457 15609451 - Rv2314c COG0312R V nonessential hypothetical protein KEEP 2587287..2588804 2587287 2588804 - 505 15609452 - Rv2315c COG0312R V nonessential hypothetical protein KEEP 2588805..2588837 2588805 2588837 I NA NA IG2353_Rv2315c-Rv2316 KEEP 2588838..2589710 2588838 2589710 + 290 15609453 uspA Rv2316 COG1175G III.A.3 nonessential sugar-transport integral membrane protein ABC transporter UspA KEEP 2589697..2590521 2589697 2590521 + 274 57116968 uspB Rv2317 COG0395G III.A.3 nonessential sugar-transport integral membrane protein ABC transporter UspB KEEP 2590518..2591840 2590518 2591840 + 440 15609455 uspC Rv2318 COG1653G III.A.3 nonessential periplasmic sugar-binding lipoprotein UspC KEEP 2591841..2591847 2591841 2591847 I NA NA IG2356_Rv2318-Rv2319c KEEP 2591848..2592726 2591848 2592726 - 292 15609456 - Rv2319c COG0589T VI essential hypothetical protein KEEP 2592723..2594153 2592723 2594153 - 476 15609457 rocE Rv2320c COG0531E III.A.1 nonessential cationic amino acid transport integral membrane protein RocE KEEP 2594154..2594699 2594154 2594699 - 181 15609458 rocD2 Rv2321c COG4992E I.A.2 nonessential ornithine aminotransferase KEEP 2594699..2595364 2594699 2595364 - 221 15609459 rocD1 Rv2322c COG4992E I.A.2 nonessential ornithine aminotransferase KEEP 2595361..2596269 2595361 2596269 - 302 15609460 - Rv2323c COG1834E V nonessential hypothetical protein KEEP 2596270..2596333 2596270 2596333 I NA NA IG2361_Rv2323c-Rv2324 KEEP 2596334..2596780 2596334 2596780 + 148 15609461 - Rv2324 COG1522K I.J.1 nonessential AsnC family transcriptional regulator KEEP 2596781..2597008 2596781 2597008 I NA NA IG2362_Rv2324-Rv2325c KEEP 2597009..2597857 2597009 2597857 - 282 15609462 - Rv2325c COG0619P V essential hypothetical protein KEEP 2597854..2599947 2597854 2599947 - 697 15609463 - Rv2326c COG1122P II.C.5 nonessential transmembrane ATP-binding protein ABC transorter KEEP 2599948..2599987 2599948 2599987 I NA NA IG2364_Rv2326c-Rv2327 KEEP 2599988..2600479 2599988 2600479 + 163 15609464 - Rv2327 COG1846K V nonessential hypothetical protein KEEP 2600480..2600730 2600480 2600730 I NA NA IG2365_Rv2327-Rv2328 KEEP 2600731..2601879 2600731 2601879 + 382 57116969 PE23 Rv2328 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 2601880..2601913 2601880 2601913 I NA NA IG2366_Rv2328-Rv2329c KEEP 2601914..2603461 2601914 2603461 - 515 15609466 narK1 Rv2329c COG2223P III.A.4 nonessential nitrite extrusion protein 1 NarK1 KEEP 2603462..2603694 2603462 2603694 I NA NA IG2367_Rv2329c-Rv2330c KEEP 2603695..2604222 2603695 2604222 - 175 15609467 lppP Rv2330c - II.C.1 nonessential lipoprotein LppP KEEP 2604223..2604296 2604223 2604296 I NA NA IG2368_Rv2330c-Rv2331 KEEP 2604297..2604683 2604297 2604683 + 128 15609468 - Rv2331 COG0243C,COG0369P VI nonessential hypothetical protein KEEP 2604684..2604739 2604684 2604739 I NA NA IG2369_Rv2331-Rv2331A KEEP 2604740..2605078 2604740 2605078 + 112 57116970 - Rv2331A COG0369P VI nonessential hypothetical protein KEEP 2605079..2605107 2605079 2605107 I NA NA IG2370_Rv2331A-Rv2332 KEEP 2605108..2606754 2605108 2606754 + 548 57116971 mez Rv2332 COG0281C I.B.7 nonessential malate dehydrogenase KEEP 2606708..2608321 2606708 2608321 - 537 15609470 - Rv2333c COG0477GEPR III.A.6 nonessential integral membrane transport protein KEEP 2608322..2608795 2608322 2608795 I NA NA IG2372_Rv2333c-Rv2334 KEEP 2608796..2609728 2608796 2609728 + 310 57116972 cysK1 Rv2334 COG0031E I.D.3 nonessential cysteine synthase A CysK1 KEEP 2609729..2609731 2609729 2609731 I NA NA IG2373_Rv2334-Rv2335 KEEP 2609732..2610421 2609732 2610421 + 229 15609472 cysE Rv2335 COG1045E I.D.3 essential serine acetyltransferase CysE KEEP 2610422..2610836 2610422 2610836 I NA NA IG2374_Rv2335-Rv2336 KEEP 2610837..2611805 2610837 2611805 + 322 15609473 - Rv2336 COG1530J VI nonessential hypothetical protein KEEP 2611806..2611868 2611806 2611868 I NA NA IG2375_Rv2336-Rv2337c KEEP 2611869..2612987 2611869 2612987 - 372 15609474 - Rv2337c - VI nonessential hypothetical protein KEEP 2612988..2613106 2612988 2613106 I NA NA IG2376_Rv2337c-Rv2338c KEEP 2613107..2614063 2613107 2614063 - 318 15609475 moeW Rv2338c COG0476H I.G.4 essential hypothetical protein KEEP 2614064..2614692 2614064 2614692 I NA NA IG2377_Rv2338c-Rv2339 KEEP 2614693..2617581 2614693 2617341 + 962 15609476 mmpL9 Rv2339 COG2409R II.C.4 nonessential transmembrane transport protein MmpL9 KEEP 2614693..2617581 2617342 2617407 + 962 15609476 mmpL9 Rv2339 COG2409R II.C.4 nonessential transmembrane transport protein MmpL9 Only Marin et al 2022 KEEP 2614693..2617581 2617408 2617581 + 962 15609476 mmpL9 Rv2339 COG2409R II.C.4 nonessential transmembrane transport protein MmpL9 KEEP 2617582..2617666 2617582 2617666 I NA NA IG2378_Rv2339-Rv2340c KEEP 2617667..2618908 2617667 2618908 - 413 57116973 PE_PGRS39 Rv2340c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2618909..2619596 2618909 2619596 I NA NA IG2379_Rv2340c-Rv2341 KEEP 2619597..2620016 2619597 2620016 + 139 15609478 lppQ Rv2341 - II.C.1 nonessential lipoprotein LppQ KEEP 2620017..2620271 2620017 2620271 I NA NA IG2380_Rv2341-Rv2342 KEEP 2620272..2620529 2620272 2620529 + 85 15609479 - Rv2342 - V nonessential hypothetical protein KEEP 2620530..2620532 2620530 2620532 I NA NA IG2381_Rv2342-Rv2343c KEEP 2620533..2622452 2620533 2622452 - 639 15609480 dnaG Rv2343c COG0358L II.A.5 essential DNA primase KEEP 2622453..2622456 2622453 2622456 I NA NA IG2382_Rv2343c-Rv2344c KEEP 2622457..2623752 2622457 2623752 - 431 15609481 dgt Rv2344c COG0232F I.F.5 nonessential deoxyguanosinetriphosphate triphosphohydrolase-like protein KEEP 2623753..2623820 2623753 2623820 I NA NA IG2383_Rv2344c-Rv2345 KEEP 2623821..2625803 2623821 2625803 + 660 15609482 - Rv2345 - II.C.2 nonessential transmembrane protein KEEP 2625804..2625887 2625804 2625881 I NA NA IG2384_Rv2345-Rv2346c KEEP 2625804..2625887 2625882 2625887 I NA NA IG2384_Rv2345-Rv2346c Only Marin et al 2022 KEEP 2625888..2626172 2625888 2626172 - 94 15609483 esxO Rv2346c - VI nonessential putative ESAT-6 like protein ESXO (ESAT-6 like protein 6) Marin et al 2022 + homoplasy analysis DISCARD 2626173..2626222 2626173 2626222 I NA NA IG2385_Rv2346c-Rv2347c Marin et al 2022 + homoplasy analysis DISCARD 2626223..2626519 2626223 2626519 - 98 15609484 esxP Rv2347c - VI nonessential putative ESAT-6 like protein ESXP (ESAT-6 like protein 7) Marin et al 2022 + homoplasy analysis DISCARD 2626520..2626653 2626520 2626653 I NA NA IG2386_Rv2347c-Rv2348c Only Marin et al 2022 KEEP 2626654..2626980 2626654 2626688 - 108 15609485 - Rv2348c - VI nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 2626654..2626980 2626689 2626980 - 108 15609485 - Rv2348c - VI nonessential hypothetical protein KEEP 2626981..2627171 2626981 2627171 I NA NA IG2387_Rv2348c-Rv2349c KEEP 2627172..2628698 2627172 2627502 - 508 15609486 plcC Rv2349c COG3511M II.B.5 nonessential phospholipase C 3 PLCC KEEP 2627172..2628698 2627503 2627556 - 508 15609486 plcC Rv2349c COG3511M II.B.5 nonessential phospholipase C 3 PLCC Only Marin et al 2022 KEEP 2627172..2628698 2627557 2628698 - 508 15609486 plcC Rv2349c COG3511M II.B.5 nonessential phospholipase C 3 PLCC KEEP 2628699..2628780 2628699 2628780 I NA NA IG2388_Rv2349c-Rv2350c KEEP 2628781..2630319 2628781 2629273 - 512 15609487 plcB Rv2350c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2628781..2630319 2629274 2629354 - 512 15609487 plcB Rv2350c COG3511M II.B.5 nonessential membrane-associated phospholipase C Only Marin et al 2022 KEEP 2628781..2630319 2629355 2629592 - 512 15609487 plcB Rv2350c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2628781..2630319 2629593 2629672 - 512 15609487 plcB Rv2350c COG3511M II.B.5 nonessential membrane-associated phospholipase C Only Marin et al 2022 KEEP 2628781..2630319 2629673 2630143 - 512 15609487 plcB Rv2350c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2628781..2630319 2630144 2630239 - 512 15609487 plcB Rv2350c COG3511M II.B.5 nonessential membrane-associated phospholipase C Marin et al 2022 + homoplasy analysis DISCARD 2628781..2630319 2630240 2630319 - 512 15609487 plcB Rv2350c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2630320..2630536 2630320 2630536 I NA NA IG2389_Rv2350c-Rv2351c KEEP 2630537..2632075 2630537 2630867 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2630537..2632075 2630868 2630926 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C Only Marin et al 2022 KEEP 2630537..2632075 2630927 2631041 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2630537..2632075 2631042 2631119 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C Only Marin et al 2022 KEEP 2630537..2632075 2631120 2631357 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2630537..2632075 2631358 2631437 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C Only Marin et al 2022 KEEP 2630537..2632075 2631438 2631597 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2630537..2632075 2631598 2631599 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C Marin et al 2022 + homoplasy analysis DISCARD 2630537..2632075 2631600 2631618 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2630537..2632075 2631619 2631620 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C Marin et al 2022 + homoplasy analysis DISCARD 2630537..2632075 2631621 2631899 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2630537..2632075 2631900 2631995 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C Only Marin et al 2022 KEEP 2630537..2632075 2631996 2632075 - 512 15609488 plcA Rv2351c COG3511M II.B.5 nonessential membrane-associated phospholipase C KEEP 2632076..2632922 2632076 2632922 I NA NA IG2390_Rv2351c-Rv2352c KEEP 2632923..2634098 2632923 2634098 - 391 57116974 PPE38 Rv2352c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2634099..2634527 2634099 2634527 I NA NA IG2391_Rv2352c-Rv2353c repeat Annotation + Marin et al 2022 DISCARD 2634528..2635592 2634528 2635592 - 354 57116975 PPE39 Rv2353c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2635593..2635627 2635593 2635627 I NA NA IG2392_Rv2353c-Rv2354 repeat Annotation + Marin et al 2022 DISCARD 2635628..2635954 2635628 2635954 + 108 15609491 - Rv2354 COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2635951..2636889 2635951 2636889 + 312 15609492 - Rv2355 COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2636890..2637687 2636890 2637037 I NA NA IG2394_Rv2355-Rv2356c repeat Annotation + Marin et al 2022 DISCARD 2636890..2637687 2637038 2637254 I NA NA IG2394_Rv2355-Rv2356c repeat KEEP 2636890..2637687 2637255 2637534 I NA NA IG2394_Rv2355-Rv2356c repeat Annotation + Marin et al 2022 DISCARD 2636890..2637687 2637535 2637687 I NA NA IG2394_Rv2355-Rv2356c repeat KEEP 2637688..2639535 2637688 2638348 - 615 57116976 PPE40 Rv2356c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2637688..2639535 2638349 2638560 - 615 57116976 PPE40 Rv2356c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2637688..2639535 2638561 2638984 - 615 57116976 PPE40 Rv2356c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2637688..2639535 2638985 2639535 - 615 57116976 PPE40 Rv2356c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2639536..2639672 2639536 2639622 I NA NA IG2395_Rv2356c-Rv2357c Annotation + Marin et al 2022 DISCARD 2639536..2639672 2639623 2639672 I NA NA IG2395_Rv2356c-Rv2357c KEEP 2639673..2641064 2639673 2641064 - 463 15609494 glyS Rv2357c COG0423J II.A.3 essential glycyl-tRNA synthetase KEEP 2641065..2641245 2641065 2641245 I NA NA IG2396_Rv2357c-Rv2358 KEEP 2641246..2641653 2641246 2641653 + 135 15609495 - Rv2358 COG0640K I.J.1 nonessential ArsR family transcriptional regulator KEEP 2641650..2642042 2641650 2642042 + 130 15609496 furB Rv2359 COG0735P I.J.1 essential ferric uptake regulation protein FURB KEEP 2642043..2642149 2642043 2642149 I NA NA IG2398_Rv2359-Rv2360c KEEP 2642150..2642578 2642150 2642578 - 142 15609497 - Rv2360c - VI nonessential hypothetical protein KEEP 2642578..2643468 2642578 2643468 - 296 15609498 - Rv2361c COG0020I VII essential long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase) KEEP 2643461..2644258 2643461 2644258 - 265 15609499 recO Rv2362c COG1381L V nonessential DNA repair protein RecO KEEP 2644259..2644319 2644259 2644319 I NA NA IG2401_Rv2362c-Rv2363 KEEP 2644320..2645774 2644320 2645774 + 484 15609500 amiA2 Rv2363 COG0154J IV.I nonessential amidase KEEP 2645771..2646673 2645771 2646673 - 300 57116977 era Rv2364c COG1159R I.F.5 essential GTP-binding protein Era KEEP 2646674..2646746 2646674 2646746 I NA NA IG2403_Rv2364c-Rv2365c KEEP 2646747..2647088 2646747 2647088 - 113 15609502 - Rv2365c - V essential hypothetical protein KEEP 2647060..2648367 2647060 2648367 - 435 15609503 - Rv2366c COG1253R II.C.5 nonessential transmembrane protein KEEP 2648364..2648912 2648364 2648912 - 182 15609504 - Rv2367c COG0319R VII nonessential putative metalloprotease KEEP 2648913..2648915 2648913 2648915 I NA NA IG2406_Rv2367c-Rv2368c KEEP 2648916..2649974 2648916 2649974 - 352 57116978 phoH1 Rv2368c COG1702T I.A.4 nonessential phosphate starvation-inducible protein PsiH KEEP 2649946..2650248 2649946 2650248 - 100 15609506 - Rv2369c - VI nonessential hypothetical protein KEEP 2650245..2651558 2650245 2651434 - 437 15609507 - Rv2370c - V nonessential hypothetical protein KEEP 2650245..2651558 2651435 2651440 - 437 15609507 - Rv2370c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2650245..2651558 2651441 2651444 - 437 15609507 - Rv2370c - V nonessential hypothetical protein KEEP 2650245..2651558 2651445 2651447 - 437 15609507 - Rv2370c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2650245..2651558 2651448 2651558 - 437 15609507 - Rv2370c - V nonessential hypothetical protein KEEP 2651559..2651752 2651559 2651752 I NA NA IG2409_Rv2370c-Rv2371 KEEP 2651753..2651938 2651753 2651842 + 61 57116979 PE_PGRS40 Rv2371 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2651753..2651938 2651843 2651910 + 61 57116979 PE_PGRS40 Rv2371 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2651753..2651938 2651911 2651938 + 61 57116979 PE_PGRS40 Rv2371 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2651939..2652036 2651939 2652036 I NA NA IG2410_Rv2371-Rv2372c KEEP 2652037..2652825 2652037 2652825 - 262 15609509 - Rv2372c COG1385S V nonessential hypothetical protein KEEP 2652826..2652838 2652826 2652838 I NA NA IG2411_Rv2372c-Rv2373c KEEP 2652839..2653987 2652839 2653987 - 382 15609510 dnaJ2 Rv2373c COG0484O III.B essential chaperone protein DnaJ2 KEEP 2653988..2654061 2653988 2654061 I NA NA IG2412_Rv2373c-Rv2374c KEEP 2654062..2655093 2654062 2655093 - 343 15609511 hrcA Rv2374c COG1420K III.B essential heat-inducible transcription repressor KEEP 2655094..2655264 2655094 2655264 I NA NA IG2413_Rv2374c-Rv2375 KEEP 2655265..2655582 2655265 2655582 + 105 15609512 - Rv2375 - V nonessential hypothetical protein KEEP 2655583..2655608 2655583 2655608 I NA NA IG2414_Rv2375-Rv2376c KEEP 2655609..2656115 2655609 2656115 - 168 15609513 cfp2 Rv2376c - VII nonessential low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) KEEP 2656116..2656214 2656116 2656214 I NA NA IG2415_Rv2376c-Rv2377c KEEP 2656215..2656430 2656215 2656430 - 71 15609514 mbtH Rv2377c COG3251S I.I nonessential putative protein MbtH KEEP 2656408..2657703 2656408 2657703 - 431 15609515 mbtG Rv2378c COG3486Q I.I essential lysine-N-oxygenase MBTG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) KEEP 2657700..2662085 2657700 2662085 - 1461 15609516 mbtF Rv2379c COG1020Q I.I nonessential peptide synthetase MBTF (peptide synthase) KEEP 2662067..2667115 2662067 2667115 - 1682 15609517 mbtE Rv2380c COG1020Q I.I nonessential peptide synthetase MBTE (peptide synthase) KEEP 2667116..2667254 2667116 2667254 I NA NA IG2419_Rv2380c-Rv2381c KEEP 2667255..2670269 2667255 2670269 - 1004 15609518 mbtD Rv2381c COG3321Q I.I nonessential polyketide synthetase MBTD (polyketide synthase) KEEP 2670269..2671603 2670269 2671603 - 444 15609519 mbtC Rv2382c COG3321Q I.I essential polyketide synthetase MBTC (polyketide synthase) KEEP 2671593..2675837 2671593 2675837 - 1414 15609520 mbtB Rv2383c COG1020Q,COG3208Q I.I nonessential phenyloxazoline synthase MBTB (phenyloxazoline synthetase) KEEP 2675838..2675935 2675838 2675935 I NA NA IG2422_Rv2383c-Rv2384 KEEP 2675936..2677633 2675936 2677633 + 565 15609521 mbtA Rv2384 COG1021Q I.I nonessential bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase KEEP 2677634..2677728 2677634 2677728 I NA NA IG2423_Rv2384-Rv2385 KEEP 2677729..2678649 2677729 2678649 + 306 57116980 mbtJ Rv2385 COG0657I II.B.5 nonessential putative acetyl hydrolase MBTJ KEEP 2678650..2678652 2678650 2678652 I NA NA IG2424_Rv2385-Rv2386c KEEP 2678653..2680005 2678653 2680005 - 450 57116981 mbtI Rv2386c COG0147EH I.D.4 essential salicylate synthase MbtI KEEP 2680006..2680764 2680006 2680764 I NA NA IG2425_Rv2386c-Rv2387 KEEP 2680765..2682018 2680765 2682018 + 417 15609524 - Rv2387 COG3329R V essential hypothetical protein KEEP 2682015..2683142 2682015 2683142 - 375 15609525 hemN Rv2388c COG0635H I.G.12 essential coproporphyrinogen III oxidase KEEP 2683143..2683247 2683143 2683247 I NA NA IG2427_Rv2388c-Rv2389c KEEP 2683248..2683712 2683248 2683500 - 154 15609526 rpfD Rv2389c - VII nonessential resuscitation-promoting factor RpfD KEEP 2683248..2683712 2683501 2683554 - 154 15609526 rpfD Rv2389c - VII nonessential resuscitation-promoting factor RpfD Only Marin et al 2022 KEEP 2683248..2683712 2683555 2683712 - 154 15609526 rpfD Rv2389c - VII nonessential resuscitation-promoting factor RpfD KEEP 2683709..2684266 2683709 2684266 - 185 15609527 - Rv2390c - V nonessential hypothetical protein KEEP 2684267..2684678 2684267 2684678 I NA NA IG2429_Rv2390c-Rv2391 KEEP 2684679..2686370 2684679 2686370 + 563 15609528 nirA Rv2391 COG0155P I.B.6b essential ferredoxin-dependent nitrite reductase NIRA KEEP 2686367..2687131 2686367 2687128 + 254 15609529 cysH Rv2392 COG0175EH I.B.6b essential phosphoadenosine phosphosulfate reductase KEEP 2686367..2687131 2687129 2687131 + 254 15609529 cysH Rv2392 COG0175EH I.B.6b essential phosphoadenosine phosphosulfate reductase Only Marin et al 2022 KEEP 2687128..2687973 2687128 2687128 + 281 15609530 - Rv2393 COG2138S V nonessential hypothetical protein KEEP 2687128..2687973 2687129 2687257 + 281 15609530 - Rv2393 COG2138S V nonessential hypothetical protein Only Marin et al 2022 KEEP 2687128..2687973 2687258 2687973 + 281 15609530 - Rv2393 COG2138S V nonessential hypothetical protein KEEP 2687974..2688009 2687974 2688009 I NA NA IG2432_Rv2393-Rv2394 KEEP 2688010..2689941 2688010 2689941 + 643 15609531 ggtB Rv2394 COG0405E I.G.10 nonessential gamma-glutamyltranspeptidase precursor GgtB KEEP 2689942..2690071 2689942 2690071 I NA NA IG2433_Rv2394-Rv2395 KEEP 2690072..2692075 2690072 2692075 + 667 15609532 - Rv2395 COG1297S II.C.5 nonessential integral membrane protein KEEP 2692076..2692798 2692076 2692798 I NA NA IG2434_Rv2395-Rv2396 KEEP 2692799..2693884 2692799 2693238 + 361 57116982 PE_PGRS41 Rv2396 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2692799..2693884 2693239 2693589 + 361 57116982 PE_PGRS41 Rv2396 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2692799..2693884 2693590 2693608 + 361 57116982 PE_PGRS41 Rv2396 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2692799..2693884 2693609 2693854 + 361 57116982 PE_PGRS41 Rv2396 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2692799..2693884 2693855 2693884 + 361 57116982 PE_PGRS41 Rv2396 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2693885..2693908 2693885 2693908 I NA NA IG2435_Rv2396-Rv2397c KEEP 2693909..2694964 2693909 2694964 - 351 57116983 cysA1 Rv2397c COG1118P III.A.4 essential sulfate-transport ATP-binding protein ABC transporter CysA1 KEEP 2694965..2694980 2694965 2694980 I NA NA IG2436_Rv2397c-Rv2398c KEEP 2694981..2695799 2694981 2695799 - 272 15609535 cysW Rv2398c COG4208P III.A.4 essential sulfate-transport integral membrane protein ABC transporter CysW KEEP 2695796..2696647 2695796 2696647 - 283 15609536 cysT Rv2399c COG0555O III.A.4 essential sulfate-transport integral membrane protein ABC transporter CysT KEEP 2696644..2697714 2696644 2697714 - 356 15609537 subI Rv2400c COG1613P III.A.4 essential sulfate-binding lipoprotein KEEP 2697715..2697727 2697715 2697727 I NA NA IG2439_Rv2400c-Rv2401 KEEP 2697728..2698057 2697728 2698057 + 109 57116984 - Rv2401 - VI nonessential hypothetical protein KEEP 2698042..2698245 2698042 2698245 - 67 57116985 - Rv2401A - II.C.5 nonessential hypothetical protein KEEP 2698246..2698528 2698246 2698528 I NA NA IG2441_Rv2401A-Rv2402 KEEP 2698529..2700457 2698529 2700457 + 642 15609539 - Rv2402 COG3387G V nonessential hypothetical protein KEEP 2700458..2700534 2700458 2700465 I NA NA IG2442_Rv2402-Rv2403c KEEP 2700458..2700534 2700466 2700531 I NA NA IG2442_Rv2402-Rv2403c Only Marin et al 2022 KEEP 2700458..2700534 2700532 2700534 I NA NA IG2442_Rv2402-Rv2403c KEEP 2700535..2701290 2700535 2701290 - 251 15609540 lppR Rv2403c - II.C.1 nonessential lipoprotein LppR KEEP 2701287..2703248 2701287 2703248 - 653 15609541 lepA Rv2404c COG0481M I.F.5 nonessential GTP-binding protein LepA KEEP 2703249..2703268 2703249 2703268 I NA NA IG2444_Rv2404c-Rv2405 KEEP 2703269..2703838 2703269 2703838 + 189 15609542 - Rv2405 - V nonessential hypothetical protein KEEP 2703839..2704008 2703839 2703890 I NA NA IG2445_Rv2405-Rv2406c KEEP 2703839..2704008 2703891 2704008 I NA NA IG2445_Rv2405-Rv2406c Only Marin et al 2022 KEEP 2704009..2704437 2704009 2704019 - 142 15609543 - Rv2406c COG0517R V nonessential hypothetical protein Only Marin et al 2022 KEEP 2704009..2704437 2704020 2704437 - 142 15609543 - Rv2406c COG0517R V nonessential hypothetical protein KEEP 2704438..2704696 2704438 2704696 I NA NA IG2446_Rv2406c-Rv2407 KEEP 2704697..2705518 2704697 2704884 + 273 15609544 - Rv2407 COG1234R VI nonessential ribonuclease Z KEEP 2704697..2705518 2704885 2704886 + 273 15609544 - Rv2407 COG1234R VI nonessential ribonuclease Z Only Marin et al 2022 KEEP 2704697..2705518 2704887 2705518 + 273 15609544 - Rv2407 COG1234R VI nonessential ribonuclease Z KEEP 2705519..2706016 2705519 2706016 I NA NA IG2447_Rv2407-Rv2408 KEEP 2706017..2706736 2706017 2706736 + 239 57116986 PE24 Rv2408 - VI PE/PPE/PGRS nonessential PE family protein KEEP 2706494..2707333 2706494 2707333 - 279 15609546 - Rv2409c COG1305E V nonessential hypothetical protein KEEP 2707333..2708310 2707333 2708310 - 325 15609547 - Rv2410c COG2307S V nonessential hypothetical protein KEEP 2708310..2709965 2708310 2709965 - 551 15609548 - Rv2411c COG2308S V nonessential hypothetical protein KEEP 2709966..2710074 2709966 2710074 I NA NA IG2451_Rv2411c-Rv2412 KEEP 2710075..2710335 2710075 2710335 + 86 15609549 rpsT Rv2412 COG0268J II.A.1 essential 30S ribosomal protein S20 KEEP 2710336..2710350 2710336 2710350 I NA NA IG2452_Rv2412-Rv2413c KEEP 2710351..2711301 2710351 2711301 - 316 15609550 - Rv2413c COG1466L V nonessential hypothetical protein KEEP 2711302..2711331 2711302 2711331 I NA NA IG2453_Rv2413c-Rv2414c KEEP 2711332..2712876 2711332 2712876 - 514 15609551 - Rv2414c COG0658R V nonessential hypothetical protein KEEP 2712877..2712890 2712877 2712890 I NA NA IG2454_Rv2414c-Rv2415c KEEP 2712891..2713784 2712891 2713784 - 297 15609552 - Rv2415c COG1555L V nonessential hypothetical protein KEEP 2713785..2714123 2713785 2714123 I NA NA IG2455_Rv2415c-Rv2416c KEEP 2714124..2715332 2714124 2715332 - 402 57116987 eis Rv2416c COG4552R VII nonessential hypothetical protein KEEP 2715333..2715471 2715333 2715471 I NA NA IG2456_Rv2416c-Rv2417c KEEP 2715472..2716314 2715472 2716307 - 280 15609554 - Rv2417c COG1307S V nonessential hypothetical protein KEEP 2715472..2716314 2716308 2716314 - 280 15609554 - Rv2417c COG1307S V nonessential hypothetical protein Only Marin et al 2022 KEEP 2716315..2716394 2716315 2716392 I NA NA IG2457_Rv2417c-Rv2418c Only Marin et al 2022 KEEP 2716315..2716394 2716393 2716394 I NA NA IG2457_Rv2417c-Rv2418c KEEP 2716395..2717138 2716395 2717138 - 247 15609555 - Rv2418c - VI essential hypothetical protein KEEP 2717128..2717799 2717128 2717799 - 223 15609556 - Rv2419c COG0406G I.B.1 nonessential phosphoglycerate mutase (phosphoglyceromutase) KEEP 2717796..2718176 2717796 2718176 - 126 15609557 - Rv2420c COG0799S V nonessential hypothetical protein KEEP 2718173..2718808 2718173 2718808 - 211 15609558 nadD Rv2421c COG1057H IV.H essential nicotinic acid mononucleotide adenylyltransferase KEEP 2718809..2719082 2718809 2719082 I NA NA IG2461_Rv2421c-Rv2422 KEEP 2719083..2719355 2719083 2719355 + 90 15609559 - Rv2422 - VI nonessential hypothetical protein KEEP 2719356..2719596 2719356 2719596 I NA NA IG2462_Rv2422-Rv2423 KEEP 2719597..2720643 2719597 2720643 + 348 15609560 - Rv2423 COG0500QR VI nonessential hypothetical protein KEEP 2720644..2720775 2720644 2720670 I NA NA IG2463_Rv2423-Rv2424c KEEP 2720644..2720775 2720671 2720775 I NA NA IG2463_Rv2423-Rv2424c Annotation + Marin et al 2022 DISCARD 2720776..2721777 2720776 2721448 - 333 15609561 - Rv2424c COG3547L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2720776..2721777 2721449 2721777 - 333 15609561 - Rv2424c COG3547L IV.B.1 phage nonessential transposase KEEP 2721778..2721865 2721778 2721811 I NA NA IG2464_Rv2424c-Rv2425c KEEP 2721778..2721865 2721812 2721865 I NA NA IG2464_Rv2424c-Rv2425c Annotation + Marin et al 2022 DISCARD 2721866..2723308 2721866 2721867 - 480 15609562 - Rv2425c COG3552R V nonessential hypothetical protein Only Marin et al 2022 KEEP 2721866..2723308 2721868 2723308 - 480 15609562 - Rv2425c COG3552R V nonessential hypothetical protein KEEP 2723308..2724183 2723308 2724183 - 291 15609563 - Rv2426c COG0714R V nonessential hypothetical protein KEEP 2724184..2724229 2724184 2724200 I NA NA IG2466_Rv2426c-Rv2427c KEEP 2724184..2724229 2724201 2724221 I NA NA IG2466_Rv2426c-Rv2427c Only Marin et al 2022 KEEP 2724184..2724229 2724222 2724229 I NA NA IG2466_Rv2426c-Rv2427c KEEP 2724230..2725477 2724230 2725477 - 415 15609564 proA Rv2427c COG0014E VII DR-inh nonessential gamma-glutamyl phosphate reductase KEEP 2725478..2726192 2725478 2726192 I NA NA IG2467_Rv2427c-Rv2428 DR-inh KEEP 2726193..2726780 2726193 2726780 + 195 15609565 ahpC Rv2428 COG0450O III.F DR-inh nonessential alkyl hydroperoxide reductase subunit C KEEP 2726781..2726805 2726781 2726805 I NA NA IG2468_Rv2428-Rv2429 KEEP 2726806..2727339 2726806 2727339 + 177 15609566 ahpD Rv2429 COG2128S III.F nonessential alkyl hydroperoxide reductase subunit D KEEP 2727336..2727920 2727336 2727920 - 194 57116988 PPE41 Rv2430c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2727921..2727966 2727921 2727966 I NA NA IG2470_Rv2430c-Rv2431c repeat KEEP 2727967..2728266 2727967 2728266 - 99 57116989 PE25 Rv2431c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 2728267..2728436 2728267 2728436 I NA NA IG2471_Rv2431c-Rv2432c KEEP 2728437..2728847 2728437 2728847 - 136 15609569 - Rv2432c - VI nonessential hypothetical protein KEEP 2728844..2729134 2728844 2729134 - 96 15609570 - Rv2433c - VI nonessential hypothetical protein KEEP 2729115..2730560 2729115 2729617 - 481 15609571 - Rv2434c COG0664T,COG0668M II.C.5 nonessential transmembrane protein KEEP 2729115..2730560 2729618 2729620 - 481 15609571 - Rv2434c COG0664T,COG0668M II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2729115..2730560 2729621 2729831 - 481 15609571 - Rv2434c COG0664T,COG0668M II.C.5 nonessential transmembrane protein KEEP 2729115..2730560 2729832 2729834 - 481 15609571 - Rv2434c COG0664T,COG0668M II.C.5 nonessential transmembrane protein Only Marin et al 2022 KEEP 2729115..2730560 2729835 2730560 - 481 15609571 - Rv2434c COG0664T,COG0668M II.C.5 nonessential transmembrane protein KEEP 2730557..2732749 2730557 2732749 - 730 15609572 - Rv2435c COG0840NT,COG2114T VII nonessential cyclase KEEP 2732750..2733229 2732750 2733229 I NA NA IG2475_Rv2435c-Rv2436 KEEP 2733230..2734144 2733230 2734144 + 304 15609573 rbsK Rv2436 COG0524G I.B.5 nonessential ribokinase RBSK KEEP 2734145..2734375 2734145 2734375 I NA NA IG2476_Rv2436-Rv2437 KEEP 2734376..2734795 2734376 2734795 + 139 15609574 - Rv2437 COG2020O V essential hypothetical protein KEEP 2734792..2736831 2734792 2736831 - 679 57116990 nadE Rv2438c COG0171H,COG0388R V essential NAD synthetase KEEP 2736709..2736987 2736709 2736987 + 92 57116991 - Rv2438A - VII nonessential hypothetical protein KEEP 2736988..2737116 2736988 2737116 I NA NA IG2479_Rv2438A-Rv2439c KEEP 2737117..2738247 2737117 2738247 - 376 15609576 proB Rv2439c COG0263E I.D.1 essential gamma-glutamyl kinase KEEP 2738247..2739686 2738247 2739686 - 479 15609577 obgE Rv2440c COG0536R I.F.5 essential GTPase ObgE KEEP 2739687..2739771 2739687 2739771 I NA NA IG2481_Rv2440c-Rv2441c KEEP 2739772..2740032 2739772 2740032 - 86 15609578 rpmA Rv2441c COG0211J II.A.1 essential 50S ribosomal protein L27 KEEP 2740033..2740046 2740033 2740046 I NA NA IG2482_Rv2441c-Rv2442c KEEP 2740047..2740361 2740047 2740361 - 104 15609579 rplU Rv2442c COG0261J II.A.1 essential 50S ribosomal protein L21 KEEP 2740362..2740708 2740362 2740573 I NA NA IG2483_Rv2442c-Rv2443 KEEP 2740362..2740708 2740574 2740601 I NA NA IG2483_Rv2442c-Rv2443 Only Marin et al 2022 KEEP 2740362..2740708 2740602 2740708 I NA NA IG2483_Rv2442c-Rv2443 KEEP 2740709..2742184 2740709 2742184 + 491 15609580 dctA Rv2443 COG1301C III.A.3 nonessential C4-dicarboxylate-transport transmembrane protein DctA KEEP 2742123..2744984 2742123 2744984 - 953 15609581 rne Rv2444c COG1530J II.B.1 essential ribonuclease E KEEP 2744985..2745313 2744985 2745313 I NA NA IG2485_Rv2444c-Rv2445c KEEP 2745314..2745724 2745314 2745724 - 136 15609582 ndk Rv2445c COG0105F I.F.5 nonessential nucleoside diphosphate kinase KEEP 2745725..2745766 2745725 2745766 I NA NA IG2486_Rv2445c-Rv2446c KEEP 2745767..2746138 2745767 2746138 - 123 15609583 - Rv2446c - II.C.5 nonessential integral membrane protein KEEP 2746135..2747598 2746135 2747598 - 487 15609584 folC Rv2447c COG0285H I.G.2 essential folylpolyglutamate synthase protein FolC KEEP 2747595..2750225 2747595 2750225 - 876 15609585 valS Rv2448c COG0525J II.A.3 essential valyl-tRNA synthetase KEEP 2750226..2750312 2750226 2750312 I NA NA IG2489_Rv2448c-Rv2449c KEEP 2750313..2751572 2750313 2751572 - 419 15609586 - Rv2449c COG3268S V nonessential hypothetical protein KEEP 2751573..2751661 2751573 2751595 I NA NA IG2490_Rv2449c-Rv2450c KEEP 2751573..2751661 2751596 2751658 I NA NA IG2490_Rv2449c-Rv2450c Only Marin et al 2022 KEEP 2751573..2751661 2751659 2751661 I NA NA IG2490_Rv2449c-Rv2450c KEEP 2751662..2752180 2751662 2752180 - 172 15609587 rpfE Rv2450c - VII nonessential resuscitation-promoting factor RpfE KEEP 2752181..2752261 2752181 2752261 I NA NA IG2491_Rv2450c-Rv2451 KEEP 2752262..2752660 2752262 2752660 + 132 15609588 - Rv2451 - VI nonessential hypothetical protein KEEP 2752661..2752847 2752661 2752847 I NA NA IG2492_Rv2451-Rv2452c KEEP 2752848..2752994 2752848 2752994 - 48 15609589 - Rv2452c - VI nonessential hypothetical protein KEEP 2752995..2753017 2752995 2753017 I NA NA IG2493_Rv2452c-Rv2453c KEEP 2753018..2753623 2753018 2753623 - 201 15609590 mobA Rv2453c COG0746H VII nonessential molybdopterin-guanine dinucleotide biosynthesis protein A KEEP 2753625..2754746 2753625 2754746 - 373 15609591 - Rv2454c COG1013C I.B.7 nonessential 2-oxoglutarate ferredoxin oxidoreductase subunit beta KEEP 2754743..2756704 2754743 2756704 - 653 15609592 - Rv2455c COG0674C,COG1014C I.B.7 nonessential oxidoreductase alpha subunit KEEP 2756705..2756935 2756705 2756935 I NA NA IG2496_Rv2455c-Rv2456c KEEP 2756936..2758192 2756936 2758192 - 418 15609593 - Rv2456c COG0477GEPR II.C.5 nonessential integral membrane transport protein KEEP 2758193..2758207 2758193 2758207 I NA NA IG2497_Rv2456c-Rv2457c KEEP 2758208..2759488 2758208 2759488 - 426 15609594 clpX Rv2457c COG1219O II.B.3 essential ATP-dependent protease ATP-binding subunit KEEP 2759489..2759778 2759489 2759778 I NA NA IG2498_Rv2457c-Rv2458 KEEP 2759779..2760687 2759779 2760687 + 302 15609595 mmuM Rv2458 COG2040E IV.H nonessential homocysteine methyltransferase KEEP 2760688..2760853 2760688 2760853 I NA NA IG2499_Rv2458-Rv2459 KEEP 2760854..2762380 2760854 2762380 + 508 15609596 - Rv2459 COG0477GEPR III.A.6 nonessential integral membrane transport protein KEEP 2762381..2762530 2762381 2762530 I NA NA IG2500_Rv2459-Rv2460c KEEP 2762531..2763175 2762531 2763175 - 214 15609597 clpP2 Rv2460c COG0740OU II.B.3 essential ATP-dependent Clp protease proteolytic subunit KEEP 2763172..2763774 2763172 2763774 - 200 57116992 clpP Rv2461c COG0740OU II.B.3 nonessential ATP-dependent Clp protease proteolytic subunit KEEP 2763775..2763890 2763775 2763890 I NA NA IG2502_Rv2461c-Rv2462c KEEP 2763891..2765291 2763891 2765291 - 466 15609599 tig Rv2462c COG0544O III.D nonessential trigger factor KEEP 2765292..2765654 2765292 2765654 I NA NA IG2503_Rv2462c-Rv2463 KEEP 2765655..2766839 2765655 2766839 + 394 15609600 lipP Rv2463 COG1680V II.B.5 nonessential esterase/lipase LipP KEEP 2766840..2766858 2766840 2766858 I NA NA IG2504_Rv2463-Rv2464c KEEP 2766859..2767665 2766859 2767665 - 268 15609601 - Rv2464c COG0266L II.A.5 nonessential DNA glycosylase KEEP 2767666..2767670 2767666 2767670 I NA NA IG2505_Rv2464c-Rv2465c KEEP 2767671..2768159 2767671 2768159 - 162 57116993 - Rv2465c COG0698G I.B.5 nonessential ribose-5-phosphate isomerase B KEEP 2768160..2768260 2768160 2768260 I NA NA IG2506_Rv2465c-Rv2466c KEEP 2768261..2768884 2768261 2768884 - 207 15609603 - Rv2466c COG3531O V nonessential hypothetical protein KEEP 2768885..2768985 2768885 2768985 I NA NA IG2507_Rv2466c-Rv2467 KEEP 2768986..2771571 2768986 2771571 + 861 57116994 pepN Rv2467 COG0308E II.B.3 nonessential aminopeptidase N KEEP 2771572..2771643 2771572 2771643 I NA NA IG2508_Rv2467-Rv2468c KEEP 2771644..2772147 2771644 2772147 - 167 15609605 - Rv2468c - V nonessential hypothetical protein KEEP 2772148..2772366 2772148 2772366 I NA NA IG2509_Rv2468c-Rv2469c KEEP 2772367..2773035 2772367 2773035 - 222 15609606 - Rv2469c COG1403V V nonessential hypothetical protein KEEP 2773036..2773177 2773036 2773177 I NA NA IG2510_Rv2469c-Rv2470 KEEP 2773178..2773564 2773178 2773564 + 128 15609607 glbO Rv2470 COG2346R I.B.6a nonessential globin GlbO KEEP 2773564..2775204 2773564 2775204 + 546 15609608 aglA Rv2471 COG0366G II.A.8 nonessential alpha-glucosidase AglA KEEP 2775205..2775271 2775205 2775271 I NA NA IG2512_Rv2471-Rv2472 KEEP 2775272..2775565 2775272 2775565 + 97 15609609 - Rv2472 - V essential hypothetical protein KEEP 2775566..2775567 2775566 2775567 I NA NA IG2513_Rv2472-Rv2473 KEEP 2775568..2776284 2775568 2776284 + 238 15609610 - Rv2473 - II.C.5 nonessential alanine and proline rich membrane protein KEEP 2776285..2776315 2776285 2776315 I NA NA IG2514_Rv2473-Rv2474c KEEP 2776316..2776969 2776316 2776969 - 217 15609611 - Rv2474c - V nonessential hypothetical protein KEEP 2776970..2776974 2776970 2776974 I NA NA IG2515_Rv2474c-Rv2475c KEEP 2776975..2777391 2776975 2777391 - 138 15609612 - Rv2475c COG0824R V nonessential hypothetical protein KEEP 2777388..2782262 2777388 2782262 - 1624 15609613 gdh Rv2476c COG2902E I.B.7 nonessential NAD-dependent glutamate dehydrogenase KEEP 2782263..2782365 2782263 2782365 I NA NA IG2517_Rv2476c-Rv2477c KEEP 2782366..2784042 2782366 2784042 - 558 15609614 - Rv2477c COG0488R III.A essential putative ABC transporter ATP-binding protein KEEP 2784043..2784122 2784043 2784122 I NA NA IG2518_Rv2477c-Rv2478c KEEP 2784123..2784608 2784123 2784600 - 161 15609615 - Rv2478c COG0629L V nonessential hypothetical protein KEEP 2784123..2784608 2784601 2784608 - 161 15609615 - Rv2478c COG0629L V nonessential hypothetical protein Only Marin et al 2022 KEEP 2784609..2784656 2784609 2784656 I NA NA IG2519_Rv2478c-Rv2479c Annotation + Marin et al 2022 DISCARD 2784657..2785697 2784657 2785697 - 346 15609616 - Rv2479c COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2785592..2785918 2785592 2785918 - 108 15609617 - Rv2480c COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 2785919..2786574 2785919 2785982 I NA NA IG2521_Rv2480c-Rv2481c Annotation + Marin et al 2022 DISCARD 2785919..2786574 2785983 2786574 I NA NA IG2521_Rv2480c-Rv2481c KEEP 2786575..2786898 2786575 2786898 - 107 15609618 - Rv2481c - VI nonessential hypothetical protein KEEP 2786899..2786913 2786899 2786913 I NA NA IG2522_Rv2481c-Rv2482c KEEP 2786914..2789283 2786914 2789283 - 789 15609619 plsB2 Rv2482c COG2937I I.H.3 nonessential glycerol-3-phosphate acyltransferase KEEP 2789280..2791022 2789280 2791022 - 580 15609620 plsC Rv2483c COG0204I,COG0560E II.C.5 essential bifunctionnal putative L-3-phosphoserine phosphatase/1-acyl-SN-glycerol-3-phosphate acyltransferase KEEP 2791019..2792494 2791019 2792494 - 491 15609621 - Rv2484c - V nonessential hypothetical protein KEEP 2792495..2792722 2792495 2792722 I NA NA IG2525_Rv2484c-Rv2485c KEEP 2792723..2793988 2792723 2793988 - 421 15609622 lipQ Rv2485c COG0657I II.B.5 nonessential carboxylesterase LipQ KEEP 2793989..2794349 2793989 2794349 I NA NA IG2526_Rv2485c-Rv2486 KEEP 2794350..2795120 2794350 2795120 + 256 15609623 echA14 Rv2486 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 2795121..2795300 2795121 2795300 I NA NA IG2527_Rv2486-Rv2487c KEEP 2795301..2797385 2795301 2795375 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2795376 2795395 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2795396 2795560 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2795561 2795578 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2795579 2795673 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2795674 2795724 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2795725 2795853 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2795854 2795868 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2795869 2795871 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2795872 2796011 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2796012 2796482 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2796483 2796488 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2796489 2796489 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2796490 2796492 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2796493 2796746 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2796747 2796761 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2796762 2796870 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2796871 2796923 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2796924 2797258 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2795301..2797385 2797259 2797355 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2795301..2797385 2797356 2797385 - 694 57116995 PE_PGRS42 Rv2487c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2797386..2797466 2797386 2797466 I NA NA IG2528_Rv2487c-Rv2488c KEEP 2797467..2800880 2797467 2800880 - 1137 15609625 - Rv2488c COG2114T,COG2771K,COG3903R I.J.1 nonessential LuxR family transcriptional regulator KEEP 2800846..2801145 2800846 2801145 - 99 15609626 - Rv2489c - VI nonessential hypothetical protein KEEP 2801146..2801253 2801146 2801253 I NA NA IG2530_Rv2489c-Rv2490c KEEP 2801254..2806236 2801254 2801404 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2801405 2801452 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2801453 2801455 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2801456 2801471 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2801472 2801821 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2801822 2802331 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2802332 2802742 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2802743 2802850 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2802851 2802852 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2802853 2803162 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2803163 2803466 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2803467 2803712 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2803713 2803720 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2803721 2803773 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2803774 2803776 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2803777 2803783 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2803784 2803822 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2803823 2803883 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2803884 2804101 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2804102 2804164 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2804165 2804374 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2804375 2804706 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2804707 2804719 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2804720 2804723 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2804724 2804745 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2804746 2804750 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2804751 2804755 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2804756 2804823 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2804824 2804905 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2804906 2805754 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2805755 2806109 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2801254..2806236 2806110 2806206 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2801254..2806236 2806207 2806236 - 1660 57116996 PE_PGRS43 Rv2490c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2806237..2806664 2806237 2806664 I NA NA IG2531_Rv2490c-Rv2491 KEEP 2806665..2807288 2806665 2807288 + 207 15609628 - Rv2491 COG1611R V nonessential hypothetical protein KEEP 2807278..2808030 2807278 2808030 + 250 15609629 - Rv2492 COG0207F VI nonessential hypothetical protein KEEP 2808031..2808082 2808031 2808082 I NA NA IG2533_Rv2492-Rv2493 KEEP 2808083..2808304 2808083 2808304 + 73 15609630 - Rv2493 - V nonessential hypothetical protein KEEP 2808305..2808309 2808305 2808309 I NA NA IG2534_Rv2493-Rv2494 KEEP 2808310..2808735 2808310 2808735 + 141 15609631 - Rv2494 COG1848R V nonessential hypothetical protein KEEP 2808736..2808757 2808736 2808757 I NA NA IG2535_Rv2494-Rv2495c KEEP 2808758..2809939 2808758 2809939 - 393 15609632 pdhC Rv2495c COG0508C I.B.2 nonessential branched-chain alpha-keto acid dehydrogenase subunit E2 KEEP 2809936..2810982 2809936 2810982 - 348 15609633 pdhB Rv2496c COG0022C I.B.2 nonessential pyruvate dehydrogenase E1 component beta subunit PdhB KEEP 2810983..2810992 2810983 2810992 I NA NA IG2537_Rv2496c-Rv2497c KEEP 2810993..2812096 2810993 2812096 - 367 15609634 pdhA Rv2497c COG1071C I.B.2 nonessential pyruvate dehydrogenase E1 component alpha subunit PdhA KEEP 2812097..2812354 2812097 2812354 I NA NA IG2538_Rv2497c-Rv2498c KEEP 2812355..2813176 2812355 2813176 - 273 15609635 citE Rv2498c COG2301G I.B.3 nonessential citrate (Pro-3S)-lyase beta subunit KEEP 2813173..2813730 2813173 2813730 - 185 15609636 - Rv2499c COG2030I I.J.1 nonessential oxidase regulatory-like protein KEEP 2813727..2814911 2813727 2814911 - 394 15609637 fadE19 Rv2500c COG1960I I.A.3 essential acyl-CoA dehydrogenase KEEP 2814912..2814915 2814912 2814915 I NA NA IG2541_Rv2500c-Rv2501c KEEP 2814916..2816880 2814916 2816880 - 654 15609638 accA1 Rv2501c COG4770I I.A.3 nonessential acetyl-/propionyl-coenzyme A carboxylase subunit alpha KEEP 2816881..2816884 2816881 2816884 I NA NA IG2542_Rv2501c-Rv2502c KEEP 2816885..2818474 2816885 2818474 - 529 15609639 accD1 Rv2502c COG4799I I.A.3 essential acetyl-/propionyl-CoA carboxylase subunit beta KEEP 2818471..2819127 2818471 2819127 - 218 15609640 scoB Rv2503c COG2057I I.A.3 nonessential succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta ScoB KEEP 2819124..2819870 2819124 2819870 - 248 15609641 scoA Rv2504c COG1788I I.A.3 nonessential succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha ScoA KEEP 2819871..2819952 2819871 2819952 I NA NA IG2545_Rv2504c-Rv2505c KEEP 2819953..2821596 2819953 2821596 - 547 15609642 fadD35 Rv2505c COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 2821597..2821711 2821597 2821711 I NA NA IG2546_Rv2505c-Rv2506 KEEP 2821712..2822359 2821712 2822359 + 215 15609643 - Rv2506 COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 2822360..2822437 2822360 2822437 I NA NA IG2547_Rv2506-Rv2507 KEEP 2822438..2823259 2822438 2822572 + 273 15609644 - Rv2507 - II.C.5 essential proline rich membrane protein KEEP 2822438..2823259 2822573 2822586 + 273 15609644 - Rv2507 - II.C.5 essential proline rich membrane protein Only Marin et al 2022 KEEP 2822438..2823259 2822587 2822616 + 273 15609644 - Rv2507 - II.C.5 essential proline rich membrane protein KEEP 2822438..2823259 2822617 2822669 + 273 15609644 - Rv2507 - II.C.5 essential proline rich membrane protein Only Marin et al 2022 KEEP 2822438..2823259 2822670 2823259 + 273 15609644 - Rv2507 - II.C.5 essential proline rich membrane protein KEEP 2823256..2824593 2823256 2824593 - 445 15609645 - Rv2508c COG2270R II.C.5 nonessential hypothetical protein KEEP 2824594..2824677 2824594 2824677 I NA NA IG2549_Rv2508c-Rv2509 KEEP 2824678..2825484 2824678 2825484 + 268 15609646 - Rv2509 COG0300R VI nonessential short-chain type dehydrogenase/reductase KEEP 2825485..2825487 2825485 2825487 I NA NA IG2550_Rv2509-Rv2510c KEEP 2825488..2827089 2825488 2827089 - 533 15609647 - Rv2510c COG0433R V essential hypothetical protein KEEP 2827090..2827156 2827090 2827156 I NA NA IG2551_Rv2510c-Rv2511 KEEP 2827157..2827804 2827157 2827804 + 215 15609648 orn Rv2511 COG1949A VII essential oligoribonuclease KEEP 2827805..2828555 2827805 2828485 I NA NA IG2552_Rv2511-Rv2512c KEEP 2827805..2828555 2828486 2828555 I NA NA IG2552_Rv2511-Rv2512c Annotation + Marin et al 2022 DISCARD 2828556..2829803 2828556 2829803 - 415 15609649 - Rv2512c COG3328L IV.B.1 phage nonessential IS1081 transposase Annotation + Marin et al 2022 DISCARD 2829804..2830160 2829804 2829938 I NA NA IG2553_Rv2512c-Rv2513 Annotation + Marin et al 2022 DISCARD 2829804..2830160 2829939 2830160 I NA NA IG2553_Rv2512c-Rv2513 KEEP 2830161..2830583 2830161 2830583 + 140 15609650 - Rv2513 - VI nonessential hypothetical protein KEEP 2830584..2830876 2830584 2830876 I NA NA IG2554_Rv2513-Rv2514c KEEP 2830877..2831338 2830877 2831338 - 153 15609651 - Rv2514c - V nonessential hypothetical protein KEEP 2831339..2831343 2831339 2831343 I NA NA IG2555_Rv2514c-Rv2515c KEEP 2831344..2832591 2831344 2832591 - 415 15609652 - Rv2515c COG1396K,COG2856E V essential hypothetical protein KEEP 2832592..2832709 2832592 2832709 I NA NA IG2556_Rv2515c-Rv2516c KEEP 2832710..2833513 2832710 2833513 - 267 57116997 - Rv2516c - VI essential hypothetical protein KEEP 2833510..2833761 2833510 2833761 - 83 15609654 - Rv2517c - VI nonessential hypothetical protein KEEP 2833762..2834108 2833762 2834108 I NA NA IG2558_Rv2517c-Rv2518c KEEP 2834109..2835335 2834109 2835335 - 408 15609655 lppS Rv2518c COG1376S II.C.1 nonessential lipoprotein LppS KEEP 2835336..2835784 2835336 2835784 I NA NA IG2559_Rv2518c-Rv2519 KEEP 2835785..2837263 2835785 2836271 + 492 57116998 PE26 Rv2519 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 2835785..2837263 2836272 2836324 + 492 57116998 PE26 Rv2519 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 2835785..2837263 2836325 2837263 + 492 57116998 PE26 Rv2519 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 2837264..2837387 2837264 2837387 I NA NA IG2560_Rv2519-Rv2520c KEEP 2837388..2837615 2837388 2837615 - 75 15609657 - Rv2520c - II.C.5 nonessential hypothetical protein KEEP 2837616..2837683 2837616 2837683 I NA NA IG2561_Rv2520c-Rv2521 KEEP 2837684..2838157 2837684 2838157 + 157 15609658 bcp Rv2521 COG1225O III.F nonessential bacterioferritin comigratory protein BCP KEEP 2838129..2839541 2838129 2839541 - 470 15609659 - Rv2522c COG0624E V nonessential hypothetical protein KEEP 2839538..2839930 2839538 2839930 - 130 15609660 acpS Rv2523c COG0736I I.H.1 nonessential 4'-phosphopantetheinyl transferase KEEP 2839931..2840122 2839931 2840122 I NA NA IG2564_Rv2523c-Rv2524c KEEP 2840123..2849332 2840123 2849332 - 3069 15609661 fas Rv2524c COG0304IQ,COG0331I,COG2030I,COG4981I,COG4982I I.H.1 essential fatty acid synthase KEEP 2849333..2849851 2849333 2849851 I NA NA IG2565_Rv2524c-Rv2525c KEEP 2849852..2850574 2849852 2850574 - 240 15609662 - Rv2525c - V nonessential hypothetical protein KEEP 2850575..2851090 2850575 2850916 I NA NA IG2566_Rv2525c-Rv2526 KEEP 2850575..2851090 2850917 2850999 I NA NA IG2566_Rv2525c-Rv2526 Only Marin et al 2022 KEEP 2850575..2851090 2851000 2851090 I NA NA IG2566_Rv2525c-Rv2526 KEEP 2851091..2851318 2851091 2851318 + 75 15609663 - Rv2526 - VI nonessential hypothetical protein KEEP 2851315..2851716 2851315 2851716 + 133 15609664 - Rv2527 COG1487R V nonessential hypothetical protein KEEP 2851717..2851750 2851717 2851750 I NA NA IG2568_Rv2527-Rv2528c KEEP 2851751..2852671 2851751 2852671 - 306 15609665 mrr Rv2528c COG1715V II.A.5 nonessential restriction system protein mrr KEEP 2852672..2852874 2852672 2852874 I NA NA IG2569_Rv2528c-Rv2529 KEEP 2852875..2854266 2852875 2854266 + 463 15609666 - Rv2529 COG1948L VI nonessential hypothetical protein KEEP 2854267..2854686 2854267 2854686 - 139 15609667 - Rv2530c COG1848R V nonessential hypothetical protein KEEP 2854687..2854907 2854687 2854907 - 74 57116999 - Rv2530A - V start-end modified for script nonessential hypothetical protein KEEP 2854908..2854937 2854908 2854937 I NA NA IG2572_Rv2530A-Rv2531c KEEP 2854938..2857781 2854938 2857781 - 947 57117000 - Rv2531c COG1982E I.A.2 nonessential amino acid decarboxylase KEEP 2857782..2857852 2857782 2857852 I NA NA IG2573_Rv2531c-Rv2532c KEEP 2857853..2858254 2857853 2858254 - 133 15609669 - Rv2532c COG0325R VI nonessential hypothetical protein KEEP 2858254..2858724 2858254 2858724 - 156 15609670 nusB Rv2533c COG0781K II.A.7 essential transcription antitermination protein NusB KEEP 2858725..2858726 2858725 2858726 I NA NA IG2575_Rv2533c-Rv2534c KEEP 2858727..2859290 2858727 2859290 - 187 15609671 efp Rv2534c COG0231J II.A.6 essential elongation factor P KEEP 2859291..2859299 2859291 2859299 I NA NA IG2576_Rv2534c-Rv2535c KEEP 2859300..2860418 2859300 2860418 - 372 15609672 pepQ Rv2535c COG0006E II.B.3 nonessential cytoplasmic peptidase PepQ KEEP 2860419..2860451 2860419 2860451 I NA NA IG2577_Rv2535c-Rv2536 KEEP 2860452..2861144 2860452 2861144 + 230 15609673 - Rv2536 - II.C.5 nonessential transmembrane protein KEEP 2861145..2861147 2861145 2861147 I NA NA IG2578_Rv2536-Rv2537c KEEP 2861148..2861591 2861148 2861591 - 147 15609674 aroD Rv2537c COG0757E I.D.4 essential 3-dehydroquinate dehydratase KEEP 2861588..2862676 2861588 2862676 - 362 15609675 aroB Rv2538c COG0337E I.D.4 essential 3-dehydroquinate synthase KEEP 2862673..2863203 2862673 2863203 - 176 15609676 aroK Rv2539c COG0703E I.D.4 essential shikimate kinase KEEP 2863204..2863206 2863204 2863206 I NA NA IG2581_Rv2539c-Rv2540c KEEP 2863207..2864412 2863207 2864412 - 401 15609677 aroF Rv2540c COG0082E I.D.4 essential chorismate synthase KEEP 2864413..2864426 2864413 2864426 I NA NA IG2582_Rv2540c-Rv2541 KEEP 2864427..2864834 2864427 2864834 + 135 15609678 - Rv2541 COG0443O VI nonessential hypothetical protein KEEP 2864835..2865129 2864835 2865129 I NA NA IG2583_Rv2541-Rv2542 KEEP 2865130..2866341 2865130 2866341 + 403 15609679 - Rv2542 - V nonessential hypothetical protein KEEP 2866342..2866467 2866342 2866464 I NA NA IG2584_Rv2542-Rv2543 KEEP 2866342..2866467 2866465 2866467 I NA NA IG2584_Rv2542-Rv2543 Only Marin et al 2022 KEEP 2866468..2867127 2866468 2866759 + 219 15609680 lppA Rv2543 - II.C.1 nonessential lipoprotein LppA Only Marin et al 2022 KEEP 2866468..2867127 2866760 2866850 + 219 15609680 lppA Rv2543 - II.C.1 nonessential lipoprotein LppA KEEP 2866468..2867127 2866851 2867127 + 219 15609680 lppA Rv2543 - II.C.1 nonessential lipoprotein LppA Marin et al 2022 + homoplasy analysis DISCARD 2867124..2867786 2867124 2867786 + 220 15609681 lppB Rv2544 - II.C.1 nonessential lipoprotein LppB Marin et al 2022 + homoplasy analysis DISCARD 2867783..2868061 2867783 2867786 + 92 15609682 - Rv2545 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2867783..2868061 2867787 2868061 + 92 15609682 - Rv2545 - V nonessential hypothetical protein KEEP 2868062..2868153 2868062 2868153 I NA NA IG2587_Rv2545-Rv2546 KEEP 2868154..2868567 2868154 2868567 + 137 15609683 - Rv2546 - V nonessential hypothetical protein KEEP 2868568..2868605 2868568 2868605 I NA NA IG2588_Rv2546-Rv2547 KEEP 2868606..2868863 2868606 2868863 + 85 15609684 - Rv2547 - V nonessential hypothetical protein KEEP 2868860..2869237 2868860 2869237 + 125 15609685 - Rv2548 COG1487R V nonessential hypothetical protein KEEP 2869238..2869726 2869238 2869726 I NA NA IG2590_Rv2548-Rv2549c KEEP 2869727..2870122 2869727 2870122 - 131 15609686 - Rv2549c COG2402R V nonessential hypothetical protein KEEP 2870119..2870364 2870119 2870364 - 81 15609687 - Rv2550c - VI nonessential hypothetical protein KEEP 2870365..2870774 2870365 2870774 I NA NA IG2592_Rv2550c-Rv2551c KEEP 2870775..2871194 2870775 2871194 - 139 15609688 - Rv2551c COG1989NOU V nonessential hypothetical protein KEEP 2871195..2871205 2871195 2871205 I NA NA IG2593_Rv2551c-Rv2552c KEEP 2871206..2872015 2871206 2872015 - 269 15609689 aroE Rv2552c COG0169E I.D.4 essential shikimate 5-dehydrogenase KEEP 2872012..2873265 2872012 2873265 - 417 15609690 - Rv2553c COG1559R II.C.4 essential hypothetical protein KEEP 2873258..2873770 2873258 2873770 - 170 15609691 - Rv2554c COG0816L V essential Holliday junction resolvase-like protein KEEP 2873771..2876485 2873771 2876485 - 904 15609692 alaS Rv2555c COG0013J II.A.3 essential alanyl-tRNA synthetase KEEP 2876486..2876575 2876486 2876575 I NA NA IG2597_Rv2555c-Rv2556c KEEP 2876576..2876965 2876576 2876965 - 129 15609693 - Rv2556c COG0432S V nonessential hypothetical protein KEEP 2876966..2877071 2876966 2877071 I NA NA IG2598_Rv2556c-Rv2557 KEEP 2877072..2877746 2877072 2877242 + 224 15609694 - Rv2557 - V nonessential hypothetical protein KEEP 2877072..2877746 2877243 2877305 + 224 15609694 - Rv2557 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2877072..2877746 2877306 2877746 + 224 15609694 - Rv2557 - V nonessential hypothetical protein KEEP 2877747..2877830 2877747 2877830 I NA NA IG2599_Rv2557-Rv2558 KEEP 2877831..2878541 2877831 2878034 + 236 15609695 - Rv2558 - V nonessential hypothetical protein KEEP 2877831..2878541 2878035 2878097 + 236 15609695 - Rv2558 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2877831..2878541 2878098 2878541 + 236 15609695 - Rv2558 - V nonessential hypothetical protein KEEP 2878542..2878570 2878542 2878570 I NA NA IG2600_Rv2558-Rv2559c KEEP 2878571..2879929 2878571 2879929 - 452 15609696 - Rv2559c COG2256L V nonessential recombination factor protein RarA KEEP 2879930..2880074 2879930 2880074 I NA NA IG2601_Rv2559c-Rv2560 KEEP 2880075..2881052 2880075 2880154 + 325 15609697 - Rv2560 - II.C.5 nonessential hypothetical protein KEEP 2880075..2881052 2880155 2880261 + 325 15609697 - Rv2560 - II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 2880075..2881052 2880262 2881052 + 325 15609697 - Rv2560 - II.C.5 nonessential hypothetical protein KEEP 2881053..2881408 2881053 2881408 I NA NA IG2602_Rv2560-Rv2561 KEEP 2881409..2881702 2881409 2881702 + 97 15609698 - Rv2561 COG0065E V nonessential hypothetical protein KEEP 2881703..2881757 2881703 2881757 I NA NA IG2603_Rv2561-Rv2562 KEEP 2881758..2882147 2881758 2882147 + 129 15609699 - Rv2562 - V nonessential hypothetical protein KEEP 2882148..2882289 2882148 2882289 I NA NA IG2604_Rv2562-Rv2563 KEEP 2882290..2883339 2882290 2883339 + 349 15609700 - Rv2563 COG0577V II.C.5 nonessential glutamine-transport transmembrane protein ABC transporter KEEP 2883340..2883341 2883340 2883341 I NA NA IG2605_Rv2563-Rv2564 KEEP 2883342..2884334 2883342 2883831 + 330 15609701 glnQ Rv2564 COG1136V III.A.1 nonessential glutamine-transport ATP-binding protein ABC transporter GlnQ KEEP 2883342..2884334 2883832 2883904 + 330 15609701 glnQ Rv2564 COG1136V III.A.1 nonessential glutamine-transport ATP-binding protein ABC transporter GlnQ Only Marin et al 2022 KEEP 2883342..2884334 2883905 2884037 + 330 15609701 glnQ Rv2564 COG1136V III.A.1 nonessential glutamine-transport ATP-binding protein ABC transporter GlnQ KEEP 2883342..2884334 2884038 2884153 + 330 15609701 glnQ Rv2564 COG1136V III.A.1 nonessential glutamine-transport ATP-binding protein ABC transporter GlnQ Only Marin et al 2022 KEEP 2883342..2884334 2884154 2884334 + 330 15609701 glnQ Rv2564 COG1136V III.A.1 nonessential glutamine-transport ATP-binding protein ABC transporter GlnQ KEEP 2884335..2884610 2884335 2884610 I NA NA IG2606_Rv2564-Rv2565 KEEP 2884611..2886362 2884611 2886362 + 583 15609702 - Rv2565 COG0664T,COG1752R V nonessential hypothetical protein KEEP 2886363..2886372 2886363 2886372 I NA NA IG2607_Rv2565-Rv2566 KEEP 2886373..2889795 2886373 2887447 + 1140 15609703 - Rv2566 COG1305E,COG4196S V nonessential hypothetical protein KEEP 2886373..2889795 2887448 2887449 + 1140 15609703 - Rv2566 COG1305E,COG4196S V nonessential hypothetical protein Only Marin et al 2022 KEEP 2886373..2889795 2887450 2889795 + 1140 15609703 - Rv2566 COG1305E,COG4196S V nonessential hypothetical protein KEEP 2889795..2892449 2889795 2892449 + 884 15609704 - Rv2567 COG2307S,COG2308S V nonessential hypothetical protein KEEP 2892446..2893471 2892446 2893471 - 341 15609705 - Rv2568c COG4307S V nonessential hypothetical protein KEEP 2893464..2894408 2893464 2894408 - 314 15609706 - Rv2569c COG1305E V nonessential hypothetical protein KEEP 2894409..2894511 2894409 2894511 I NA NA IG2611_Rv2569c-Rv2570 KEEP 2894512..2894901 2894512 2894901 + 129 15609707 - Rv2570 COG3801S V nonessential hypothetical protein KEEP 2894893..2895960 2894893 2895960 - 355 15609708 - Rv2571c COG4129S II.C.5 nonessential transmembrane alanine and valine and leucine rich protein KEEP 2895961..2896012 2895961 2896012 I NA NA IG2613_Rv2571c-Rv2572c KEEP 2896013..2897803 2896013 2897803 - 596 15609709 aspS Rv2572c COG0173J II.A.3 nonessential aspartyl-tRNA synthetase KEEP 2897804..2897955 2897804 2897955 I NA NA IG2614_Rv2572c-Rv2573 KEEP 2897956..2898783 2897956 2898783 + 275 161352464 - Rv2573 COG1893H V nonessential 2-dehydropantoate 2-reductase KEEP 2898784..2898805 2898784 2898805 I NA NA IG2615_Rv2573-Rv2574 KEEP 2898806..2899309 2898806 2899309 + 167 15609711 - Rv2574 - V nonessential hypothetical protein KEEP 2899310..2899338 2899310 2899338 I NA NA IG2616_Rv2574-Rv2575 KEEP 2899339..2900220 2899339 2900220 + 293 15609712 - Rv2575 COG2321R II.C.5 nonessential hypothetical protein KEEP 2900221..2900225 2900221 2900225 I NA NA IG2617_Rv2575-Rv2576c KEEP 2900226..2900690 2900226 2900690 - 154 15609713 - Rv2576c - II.C.5 nonessential hypothetical protein KEEP 2900691..2900917 2900691 2900917 I NA NA IG2618_Rv2576c-Rv2577 KEEP 2900918..2902507 2900918 2902507 + 529 15609714 - Rv2577 COG1409R,COG3540P V nonessential hypothetical protein KEEP 2902509..2903531 2902509 2903531 - 340 15609715 - Rv2578c COG1533L V nonessential hypothetical protein KEEP 2903532..2903638 2903532 2903638 I NA NA IG2620_Rv2578c-Rv2579 KEEP 2903639..2904541 2903639 2904541 + 300 57117001 dhaA Rv2579 COG0596R IV.I nonessential haloalkane dehalogenase KEEP 2904542..2904820 2904542 2904820 I NA NA IG2621_Rv2579-Rv2580c KEEP 2904821..2906092 2904821 2906092 - 423 15609717 hisS Rv2580c COG0124J II.A.3 essential histidyl-tRNA synthetase KEEP 2906089..2906763 2906089 2906763 - 224 15609718 - Rv2581c COG0491R III.F nonessential glyoxalase II KEEP 2906764..2906813 2906764 2906813 I NA NA IG2623_Rv2581c-Rv2582 KEEP 2906814..2907740 2906814 2907740 + 308 15609719 ppiB Rv2582 COG0652O II.A.6 essential peptidyl-prolyl cis-trans isomerase B KEEP 2907741..2907825 2907741 2907825 I NA NA IG2624_Rv2582-Rv2583c KEEP 2907826..2910198 2907826 2910198 - 790 15609720 relA Rv2583c COG0317TK I.F.5 nonessential GTP pyrophosphokinase KEEP 2910199..2910228 2910199 2910228 I NA NA IG2625_Rv2583c-Rv2584c KEEP 2910229..2910900 2910229 2910900 - 223 15609721 apt Rv2584c COG0503F I.F.4 nonessential adenine phosphoribosyltransferase KEEP 2910901..2911003 2910901 2911003 I NA NA IG2626_Rv2584c-Rv2585c KEEP 2911004..2912677 2911004 2912677 - 557 15609722 - Rv2585c COG0747E II.C.1 nonessential lipoprotein KEEP 2912678..2912682 2912678 2912682 I NA NA IG2627_Rv2585c-Rv2586c KEEP 2912683..2914011 2912683 2914011 - 442 15609723 secF Rv2586c COG0341U III.D nonessential preprotein translocase subunit SecF KEEP 2914012..2914014 2914012 2914014 I NA NA IG2628_Rv2586c-Rv2587c KEEP 2914015..2915736 2914015 2915736 - 573 15609724 secD Rv2587c COG0342U III.D nonessential preprotein translocase subunit SecD KEEP 2915737..2915845 2915737 2915845 I NA NA IG2629_Rv2587c-Rv2588c KEEP 2915846..2916193 2915846 2916193 - 115 15609725 yajC Rv2588c COG1862U II.C.4 nonessential preprotein translocase subunit YajC KEEP 2916194..2916359 2916194 2916359 I NA NA IG2630_Rv2588c-Rv2589 KEEP 2916360..2917709 2916360 2917709 + 449 15609726 gabT Rv2589 COG0160E I.C.1 nonessential 4-aminobutyrate aminotransferase KEEP 2917710..2917870 2917710 2917870 I NA NA IG2631_Rv2589-Rv2590 KEEP 2917871..2921377 2917871 2921377 + 1168 15609727 fadD9 Rv2590 COG1022I,COG3320Q I.A.3 nonessential fatty-acid-CoA ligase KEEP 2921378..2921550 2921378 2921550 I NA NA IG2632_Rv2590-Rv2591 KEEP 2921551..2923182 2921551 2921968 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2921969 2922026 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2922027 2922096 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2922097 2922119 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2922120 2922180 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2922181 2922254 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2922255 2922356 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2922357 2922373 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2922374 2922435 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2922436 2922459 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2922460 2922724 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2922725 2922835 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2922836 2922866 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2922867 2922930 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2922931 2922936 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2922937 2922960 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2922961 2923090 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2921551..2923182 2923091 2923143 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2921551..2923182 2923144 2923182 + 543 57117002 PE_PGRS44 Rv2591 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2923183..2923198 2923183 2923198 I NA NA IG2633_Rv2591-Rv2592c KEEP 2923199..2924233 2923199 2924233 - 344 15609729 ruvB Rv2592c COG2255L II.A.5 nonessential Holliday junction DNA helicase B KEEP 2924230..2924820 2924230 2924820 - 196 15609730 ruvA Rv2593c COG0632L II.A.5 nonessential Holliday junction DNA helicase motor protein KEEP 2924817..2925383 2924817 2925383 - 188 15609731 ruvC Rv2594c COG0817L II.A.5 nonessential Holliday junction resolvase KEEP 2925384..2925491 2925384 2925491 I NA NA IG2636_Rv2594c-Rv2595 KEEP 2925492..2925737 2925492 2925737 + 81 15609732 - Rv2595 COG2002K V nonessential hypothetical protein KEEP 2925734..2926138 2925734 2926138 + 134 15609733 - Rv2596 - V nonessential hypothetical protein KEEP 2926139..2926354 2926139 2926354 I NA NA IG2638_Rv2596-Rv2597 KEEP 2926355..2926975 2926355 2926975 + 206 15609734 - Rv2597 - II.C.5 nonessential hypothetical protein KEEP 2926976..2926985 2926976 2926985 I NA NA IG2639_Rv2597-Rv2598 KEEP 2926986..2927480 2926986 2927480 + 164 15609735 - Rv2598 - V nonessential hypothetical protein KEEP 2927477..2927908 2927477 2927908 + 143 15609736 - Rv2599 COG0449M II.C.4 nonessential hypothetical protein KEEP 2927909..2927989 2927909 2927989 I NA NA IG2641_Rv2599-Rv2600 KEEP 2927990..2928391 2927990 2928391 + 133 15609737 - Rv2600 - II.C.5 nonessential integral membrane protein KEEP 2928388..2929959 2928388 2929959 + 523 57117003 speE Rv2601 COG4262R I.E nonessential spermidine synthase KEEP 2929960..2930069 2929960 2930069 I NA NA IG2643_Rv2601-Rv2601A KEEP 2930070..2930357 2930070 2930357 + 95 57117004 - Rv2601A COG4691R V nonessential hypothetical protein KEEP 2930344..2930784 2930344 2930784 + 146 15609739 - Rv2602 - V nonessential hypothetical protein KEEP 2930785..2930804 2930785 2930804 I NA NA IG2645_Rv2602-Rv2603c KEEP 2930805..2931560 2930805 2931560 - 251 15609740 - Rv2603c COG0217S V nonessential hypothetical protein KEEP 2931561..2931692 2931561 2931692 I NA NA IG2646_Rv2603c-Rv2604c KEEP 2931693..2932289 2931693 2932289 - 198 15609741 - Rv2604c COG0311H V nonessential glutamine amidotransferase subunit PdxT KEEP 2932290..2932296 2932290 2932296 I NA NA IG2647_Rv2604c-Rv2605c KEEP 2932297..2933142 2932297 2933142 - 281 15609742 tesB2 Rv2605c COG1946I I.H.1 nonessential acyl-CoA thioesterase II KEEP 2933143..2933170 2933143 2933170 I NA NA IG2648_Rv2605c-Rv2606c KEEP 2933171..2934070 2933171 2934070 - 299 15609743 - Rv2606c COG0214H VII nonessential pyridoxine biosynthesis protein KEEP 2934071..2934197 2934071 2934197 I NA NA IG2649_Rv2606c-Rv2607 KEEP 2934198..2934872 2934198 2934872 + 224 15609744 pdxH Rv2607 COG0259H I.G.6 nonessential pyridoxamine 5'-phosphate oxidase KEEP 2934873..2935045 2934873 2935045 I NA NA IG2650_Rv2607-Rv2608 KEEP 2935046..2936788 2935046 2935118 + 580 57117005 PPE42 Rv2608 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2935046..2936788 2935119 2935172 + 580 57117005 PPE42 Rv2608 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 2935046..2936788 2935173 2936788 + 580 57117005 PPE42 Rv2608 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 2936789..2936809 2936789 2936809 I NA NA IG2651_Rv2608-Rv2609c KEEP 2936810..2937865 2936810 2937865 - 351 15609746 - Rv2609c - II.C.4 nonessential hypothetical protein KEEP 2937865..2939001 2937865 2939001 - 378 15609747 pimA Rv2610c COG0438M IV.H nonessential alpha-mannosyltransferase PIMA KEEP 2939002..2939011 2939002 2939011 I NA NA IG2653_Rv2610c-Rv2611c KEEP 2939012..2939962 2939012 2939962 - 316 15609748 - Rv2611c COG1560M IV.H essential lipid A biosynthesis lauroyl acyltransferase KEEP 2939959..2940612 2939959 2940612 - 217 57117006 pgsA1 Rv2612c COG0558I I.H.3 essential CDP-diacylglycerol--inositol 3-phosphatidyltransferase KEEP 2940609..2941196 2940609 2941196 - 195 15609750 - Rv2613c COG0537FGR V essential hypothetical protein KEEP 2941189..2943267 2941189 2943267 - 692 15609751 thrS Rv2614c COG0441J V essential threonyl-tRNA synthetase KEEP 2943268..2943375 2943268 2943375 I NA NA IG2657_Rv2614c-Rv2614A KEEP 2943376..2943603 2943376 2943603 + 75 57117007 - Rv2614A COG0149G II.A.3 nonessential hypothetical protein KEEP 2943600..2944985 2943600 2943753 - 461 57117008 PE_PGRS45 Rv2615c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2943600..2944985 2943754 2943801 - 461 57117008 PE_PGRS45 Rv2615c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2943600..2944985 2943802 2944204 - 461 57117008 PE_PGRS45 Rv2615c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2943600..2944985 2944205 2944985 - 461 57117008 PE_PGRS45 Rv2615c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2944986..2945329 2944986 2945233 I NA NA IG2659_Rv2615c-Rv2616 Annotation + Marin et al 2022 DISCARD 2944986..2945329 2945234 2945329 I NA NA IG2659_Rv2615c-Rv2616 KEEP 2945330..2945830 2945330 2945830 + 166 15609753 - Rv2616 COG4762S V nonessential hypothetical protein KEEP 2945831..2945846 2945831 2945846 I NA NA IG2660_Rv2616-Rv2617c KEEP 2945847..2946287 2945847 2946287 - 146 15609754 - Rv2617c - II.C.5 nonessential hypothetical protein KEEP 2946288..2946433 2946288 2946433 I NA NA IG2661_Rv2617c-Rv2618 KEEP 2946434..2947111 2946434 2947111 + 225 15609755 - Rv2618 COG2345K V nonessential hypothetical protein KEEP 2947096..2947449 2947096 2947449 - 117 15609756 - Rv2619c COG1917S V nonessential hypothetical protein KEEP 2947450..2947461 2947450 2947461 I NA NA IG2663_Rv2619c-Rv2620c KEEP 2947462..2947887 2947462 2947887 - 141 15609757 - Rv2620c - II.C.5 nonessential transmembrane protein KEEP 2947884..2948558 2947884 2948558 - 224 15609758 - Rv2621c COG2345K I.J.1 nonessential transcriptional regulatory protein KEEP 2948559..2948635 2948559 2948635 I NA NA IG2665_Rv2621c-Rv2622 KEEP 2948636..2949457 2948636 2949457 + 273 15609759 - Rv2622 COG0500QR IV.H nonessential methyltransferase (methylase) KEEP 2949458..2949592 2949458 2949592 I NA NA IG2666_Rv2622-Rv2623 KEEP 2949593..2950486 2949593 2950486 + 297 15609760 TB31.7 Rv2623 COG0589T V essential hypothetical protein KEEP 2950487..2950488 2950487 2950488 I NA NA IG2667_Rv2623-Rv2624c KEEP 2950489..2951307 2950489 2951307 - 272 15609761 - Rv2624c COG0589T V nonessential hypothetical protein KEEP 2951308..2951321 2951308 2951321 I NA NA IG2668_Rv2624c-Rv2625c KEEP 2951322..2952503 2951322 2952503 - 393 15609762 - Rv2625c COG0517R,COG1994R II.C.5 nonessential hypothetical protein KEEP 2952504..2952561 2952504 2952561 I NA NA IG2669_Rv2625c-Rv2626c KEEP 2952562..2952993 2952562 2952993 - 143 15609763 - Rv2626c COG0517R V nonessential hypothetical protein KEEP 2952994..2953506 2952994 2953435 I NA NA IG2670_Rv2626c-Rv2627c KEEP 2952994..2953506 2953436 2953506 I NA NA IG2670_Rv2626c-Rv2627c Only Marin et al 2022 KEEP 2953507..2954748 2953507 2953513 - 413 15609764 - Rv2627c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 2953507..2954748 2953514 2954748 - 413 15609764 - Rv2627c - V nonessential hypothetical protein KEEP 2954749..2955057 2954749 2955057 I NA NA IG2671_Rv2627c-Rv2628 KEEP 2955058..2955420 2955058 2955420 + 120 15609765 - Rv2628 - VI nonessential hypothetical protein KEEP 2955421..2955766 2955421 2955766 I NA NA IG2672_Rv2628-Rv2629 KEEP 2955767..2956891 2955767 2956891 + 374 15609766 - Rv2629 COG0272L,COG1503J V nonessential hypothetical protein KEEP 2956893..2957432 2956893 2957432 + 179 15609767 - Rv2630 COG1371S VI nonessential hypothetical protein KEEP 2957433..2957571 2957433 2957571 I NA NA IG2674_Rv2630-Rv2631 KEEP 2957572..2958870 2957572 2958870 + 432 57117009 - Rv2631 COG1690S V nonessential hypothetical protein KEEP 2958871..2958908 2958871 2958908 I NA NA IG2675_Rv2631-Rv2632c KEEP 2958909..2959190 2958909 2959190 - 93 15609769 - Rv2632c - V nonessential hypothetical protein KEEP 2959191..2959334 2959191 2959334 I NA NA IG2676_Rv2632c-Rv2633c KEEP 2959335..2959820 2959335 2959820 - 161 15609770 - Rv2633c - VI nonessential hypothetical protein KEEP 2959821..2960104 2959821 2960104 I NA NA IG2677_Rv2633c-Rv2634c KEEP 2960105..2962441 2960105 2960225 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2960226 2960592 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2960593 2960876 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2960877 2960880 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2960881 2960928 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2960929 2961063 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961064 2961068 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961069 2961071 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961072 2961077 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961078 2961083 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961084 2961084 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961085 2961231 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961232 2961333 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961334 2961341 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961342 2961354 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961355 2961356 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961357 2961365 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961366 2961401 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961402 2961408 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961409 2961412 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961413 2961445 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961446 2961938 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961939 2961960 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2960105..2962441 2961961 2961962 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 2960105..2962441 2961963 2962441 - 778 57117010 PE_PGRS46 Rv2634c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 2962442..2962469 2962442 2962469 I NA NA IG2678_Rv2634c-Rv2635 KEEP 2962470..2962712 2962470 2962712 + 80 15609772 - Rv2635 - VI nonessential hypothetical protein KEEP 2962713..2963390 2962713 2963390 + 225 15609773 - Rv2636 COG3896V V nonessential hypothetical protein KEEP 2963391..2963585 2963391 2963585 I NA NA IG2680_Rv2636-Rv2637 KEEP 2963586..2964242 2963586 2964242 + 218 15609774 dedA Rv2637 COG0586S II.C.5 nonessential transmembrane protein DedA KEEP 2964243..2964404 2964243 2964404 I NA NA IG2681_Rv2637-Rv2638 KEEP 2964405..2964851 2964405 2964851 + 148 15609775 - Rv2638 COG1366T V nonessential hypothetical protein KEEP 2964852..2965025 2964852 2965025 I NA NA IG2682_Rv2638-Rv2639c KEEP 2965026..2965358 2965026 2965358 - 110 15609776 - Rv2639c COG1742S II.C.5 nonessential hypothetical protein KEEP 2965359..2965477 2965359 2965477 I NA NA IG2683_Rv2639c-Rv2640c KEEP 2965478..2965837 2965478 2965837 - 119 15609777 - Rv2640c COG0640K I.J.1 nonessential ArsR family transcriptional regulator KEEP 2965838..2965938 2965838 2965938 I NA NA IG2684_Rv2640c-Rv2641 KEEP 2965939..2966397 2965939 2966397 + 152 15609778 cadI Rv2641 COG0346E VI nonessential cadmium inducible protein CADI KEEP 2966398..2966532 2966398 2966532 I NA NA IG2685_Rv2641-Rv2642 KEEP 2966533..2966913 2966533 2966913 + 126 15609779 - Rv2642 COG0640K I.J.1 nonessential ArsR family transcriptional regulator KEEP 2966910..2968406 2966910 2968406 + 498 15609780 arsC Rv2643 COG0394T,COG0798P III.A.4 nonessential arsenic-transport integral membrane protein ArsC KEEP 2968407..2968532 2968407 2968532 I NA NA IG2687_Rv2643-Rv2644c KEEP 2968533..2968850 2968533 2968850 - 105 15609781 - Rv2644c - VI nonessential hypothetical protein KEEP 2968851..2970122 2968851 2970122 I NA NA IG2688_Rv2644c-Rv2645 KEEP 2970123..2970554 2970123 2970554 + 143 15609782 - Rv2645 - VI nonessential hypothetical protein KEEP 2970551..2971549 2970551 2971549 + 332 15609783 - Rv2646 COG0582L IV.B.3 phage nonessential integrase KEEP 2971550..2971658 2971550 2971658 I NA NA IG2690_Rv2646-Rv2647 KEEP 2971659..2972027 2971659 2971754 + 122 15609784 - Rv2647 - IV.B.3 nonessential hypothetical protein KEEP 2971659..2972027 2971755 2971868 + 122 15609784 - Rv2647 - IV.B.3 nonessential hypothetical protein Only Marin et al 2022 KEEP 2971659..2972027 2971869 2971939 + 122 15609784 - Rv2647 - IV.B.3 nonessential hypothetical protein KEEP 2971659..2972027 2971940 2971990 + 122 15609784 - Rv2647 - IV.B.3 nonessential hypothetical protein Only Marin et al 2022 KEEP 2971659..2972027 2971991 2972027 + 122 15609784 - Rv2647 - IV.B.3 nonessential hypothetical protein KEEP 2972028..2972159 2972028 2972100 I NA NA IG2691_Rv2647-Rv2648 KEEP 2972028..2972159 2972101 2972159 I NA NA IG2691_Rv2647-Rv2648 Annotation + Marin et al 2022 DISCARD 2972160..2972486 2972160 2972486 + 108 15609785 - Rv2648 COG2963L IV.B.1 phage nonessential transposase IS6110 Annotation + Marin et al 2022 DISCARD 2972435..2973421 2972435 2973421 + 328 15609786 - Rv2649 COG2801L IV.B.1 phage nonessential transposase IS6110 Annotation + Marin et al 2022 DISCARD 2973422..2973794 2973422 2973473 I NA NA IG2693_Rv2649-Rv2650c repeat Annotation + Marin et al 2022 DISCARD 2973422..2973794 2973474 2973794 I NA NA IG2693_Rv2649-Rv2650c repeat KEEP 2973795..2975234 2973795 2974049 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2973795..2975234 2974050 2974162 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein Annotation + Marin et al 2022 DISCARD 2973795..2975234 2974163 2974272 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2973795..2975234 2974273 2974345 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein Annotation + Marin et al 2022 DISCARD 2973795..2975234 2974346 2974409 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2973795..2975234 2974410 2974758 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein Annotation + Marin et al 2022 DISCARD 2973795..2975234 2974759 2974766 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2973795..2975234 2974767 2975136 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein Annotation + Marin et al 2022 DISCARD 2973795..2975234 2975137 2975234 - 479 15609787 - Rv2650c COG4653R IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2975235..2975241 2975235 2975241 I NA NA IG2694_Rv2650c-Rv2651c repeat KEEP 2975242..2975775 2975242 2975262 - 177 15609788 - Rv2651c COG3740R IV.B.3 phage nonessential phiRv2 prophage protease KEEP 2975242..2975775 2975263 2975329 - 177 15609788 - Rv2651c COG3740R IV.B.3 phage nonessential phiRv2 prophage protease Annotation + Marin et al 2022 DISCARD 2975242..2975775 2975330 2975389 - 177 15609788 - Rv2651c COG3740R IV.B.3 phage nonessential phiRv2 prophage protease KEEP 2975242..2975775 2975390 2975461 - 177 15609788 - Rv2651c COG3740R IV.B.3 phage nonessential phiRv2 prophage protease Annotation + Marin et al 2022 DISCARD 2975242..2975775 2975462 2975464 - 177 15609788 - Rv2651c COG3740R IV.B.3 phage nonessential phiRv2 prophage protease KEEP 2975242..2975775 2975465 2975697 - 177 15609788 - Rv2651c COG3740R IV.B.3 phage nonessential phiRv2 prophage protease Annotation + Marin et al 2022 DISCARD 2975242..2975775 2975698 2975725 - 177 15609788 - Rv2651c COG3740R IV.B.3 phage nonessential phiRv2 prophage protease KEEP 2975242..2975775 2975726 2975775 - 177 15609788 - Rv2651c COG3740R IV.B.3 phage nonessential phiRv2 prophage protease Annotation + Marin et al 2022 DISCARD 2975776..2975927 2975776 2975927 I NA NA IG2695_Rv2651c-Rv2652c repeat Annotation + Marin et al 2022 DISCARD 2975928..2976554 2975928 2975962 - 208 15609789 - Rv2652c - IV.B.3 phage nonessential phiRv2 prophage protein Annotation + Marin et al 2022 DISCARD 2975928..2976554 2975963 2976554 - 208 15609789 - Rv2652c - IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2976555..2976585 2976555 2976585 I NA NA IG2696_Rv2652c-Rv2653c repeat Annotation + homoplasy analysis DISCARD 2976586..2976909 2976586 2976909 - 107 15609790 - Rv2653c COG1200LK IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2976910..2976988 2976910 2976988 I NA NA IG2697_Rv2653c-Rv2654c repeat KEEP 2976989..2977234 2976989 2977234 - 81 15609791 - Rv2654c - IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2977231..2978658 2977231 2978658 - 475 15609792 - Rv2655c - IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2978660..2979052 2978660 2978904 - 130 15609793 - Rv2656c - IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2978660..2979052 2978905 2979050 - 130 15609793 - Rv2656c - IV.B.3 phage nonessential phiRv2 prophage protein Annotation + Marin et al 2022 DISCARD 2978660..2979052 2979051 2979052 - 130 15609793 - Rv2656c - IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2979049..2979309 2979049 2979050 - 86 15609794 - Rv2657c - IV.B.3 phage nonessential phiRv2 prophage protein Annotation + Marin et al 2022 DISCARD 2979049..2979309 2979051 2979309 - 86 15609794 - Rv2657c - IV.B.3 phage nonessential phiRv2 prophage protein KEEP 2979310..2979325 2979310 2979325 I NA NA IG2701_Rv2657c-Rv2658c repeat KEEP 2979326..2979688 2979326 2979688 - 120 15609795 - Rv2658c - IV.B.3 phage nonessential prophage protein KEEP 2979689..2979690 2979689 2979690 I NA NA IG2702_Rv2658c-Rv2659c repeat KEEP 2979691..2980818 2979691 2980818 - 375 15609796 - Rv2659c COG0582L IV.B.3 phage nonessential phiRv2 prophage integrase KEEP 2980819..2980962 2980819 2980962 I NA NA IG2703_Rv2659c-Rv2660c KEEP 2980963..2981190 2980963 2980969 - 75 15609797 - Rv2660c - VI nonessential hypothetical protein KEEP 2980963..2981190 2980970 2980998 - 75 15609797 - Rv2660c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 2980963..2981190 2980999 2981190 - 75 15609797 - Rv2660c - VI nonessential hypothetical protein KEEP 2981187..2981576 2981187 2981576 - 129 15609798 - Rv2661c - VI nonessential hypothetical protein KEEP 2981482..2981754 2981482 2981754 + 90 15609799 - Rv2662 - VI nonessential hypothetical protein KEEP 2981755..2981852 2981755 2981852 I NA NA IG2706_Rv2662-Rv2663 KEEP 2981853..2982086 2981853 2982086 + 77 15609800 - Rv2663 - VI nonessential hypothetical protein KEEP 2982087..2982096 2982087 2982096 I NA NA IG2707_Rv2663-Rv2664 KEEP 2982097..2982351 2982097 2982351 + 84 15609801 - Rv2664 - VI nonessential hypothetical protein KEEP 2982352..2982698 2982352 2982698 I NA NA IG2708_Rv2664-Rv2665 KEEP 2982699..2982980 2982699 2982936 + 93 15609802 - Rv2665 - VI nonessential hypothetical protein KEEP 2982699..2982980 2982937 2982980 + 93 15609802 - Rv2665 - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 2982981..2983070 2982981 2983070 I NA NA IG2709_Rv2665-Rv2666 Annotation + Marin et al 2022 DISCARD 2983071..2983874 2983071 2983859 + 267 15609803 - Rv2666 COG3328L IV.B.1 phage nonessential truncated IS1081 transposase Annotation + Marin et al 2022 DISCARD 2983071..2983874 2983860 2983874 + 267 15609803 - Rv2666 COG3328L IV.B.1 phage nonessential truncated IS1081 transposase KEEP 2983875..2983895 2983875 2983895 I NA NA IG2710_Rv2666-Rv2667 KEEP 2983896..2984654 2983896 2984654 + 252 57117011 clpC2 Rv2667 COG0542O II.B.3 nonessential ATP-dependent protease ATP-binding subunit ClpC2 KEEP 2984655..2984732 2984655 2984732 I NA NA IG2711_Rv2667-Rv2668 KEEP 2984733..2985254 2984733 2985254 + 173 15609805 - Rv2668 - VI nonessential hypothetical protein KEEP 2985255..2985282 2985255 2985282 I NA NA IG2712_Rv2668-Rv2669 KEEP 2985283..2985753 2985283 2985753 + 156 15609806 - Rv2669 COG0454KR I.J.1 nonessential hypothetical protein KEEP 2985731..2986840 2985731 2986840 - 369 15609807 - Rv2670c COG1485R V nonessential hypothetical protein KEEP 2986839..2987615 2986839 2987615 + 258 15609808 ribD Rv2671 COG1985H I.G.9 nonessential hypothetical protein KEEP 2987616..2987681 2987616 2987681 I NA NA IG2715_Rv2671-Rv2672 KEEP 2987682..2989268 2987682 2989268 + 528 15609809 - Rv2672 COG0596R II.C.2 nonessential secreted protease KEEP 2989269..2989290 2989269 2989290 I NA NA IG2716_Rv2672-Rv2673 KEEP 2989291..2990592 2989291 2989949 + 433 15609810 - Rv2673 - II.C.5 essential integral membrane protein KEEP 2989291..2990592 2989950 2989952 + 433 15609810 - Rv2673 - II.C.5 essential integral membrane protein Only Marin et al 2022 KEEP 2989291..2990592 2989953 2990577 + 433 15609810 - Rv2673 - II.C.5 essential integral membrane protein KEEP 2989291..2990592 2990578 2990592 + 433 15609810 - Rv2673 - II.C.5 essential integral membrane protein Only Marin et al 2022 KEEP 2990593..2990705 2990593 2990705 I NA NA IG2717_Rv2673-Rv2674 Only Marin et al 2022 KEEP 2990706..2991116 2990706 2991116 + 136 15609811 - Rv2674 COG0229O V nonessential hypothetical protein KEEP 2991117..2991183 2991117 2991183 I NA NA IG2718_Rv2674-Rv2675c KEEP 2991184..2991936 2991184 2991936 - 250 15609812 - Rv2675c COG0500QR V nonessential hypothetical protein KEEP 2991933..2992628 2991933 2992628 - 231 15609813 - Rv2676c COG3253S V nonessential hypothetical protein KEEP 2992629..2992633 2992629 2992633 I NA NA IG2720_Rv2676c-Rv2677c KEEP 2992634..2993992 2992634 2993992 - 452 57117012 hemY Rv2677c COG1232H I.G.12 nonessential protoporphyrinogen oxidase KEEP 2993989..2995062 2993989 2995062 - 357 15609815 hemE Rv2678c COG0407H I.G.12 nonessential uroporphyrinogen decarboxylase KEEP 2995063..2995114 2995063 2995114 I NA NA IG2722_Rv2678c-Rv2679 KEEP 2995115..2995945 2995115 2995945 + 276 15609816 echA15 Rv2679 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 2995946..2996104 2995946 2995999 I NA NA IG2723_Rv2679-Rv2680 KEEP 2995946..2996104 2996000 2996104 I NA NA IG2723_Rv2679-Rv2680 Only Marin et al 2022 KEEP 2996105..2996737 2996105 2996173 + 210 15609817 - Rv2680 COG1629P V nonessential hypothetical protein Only Marin et al 2022 KEEP 2996105..2996737 2996174 2996737 + 210 15609817 - Rv2680 COG1629P V nonessential hypothetical protein KEEP 2996739..2998055 2996739 2998055 + 438 15609818 - Rv2681 COG0349J V nonessential hypothetical protein KEEP 2998052..2999968 2998052 2999968 - 638 57117013 dxs1 Rv2682c COG1154HI I.G.11 essential 1-deoxy-D-xylulose-5-phosphate synthase KEEP 2999969..3000111 2999969 3000111 I NA NA IG2726_Rv2682c-Rv2683 KEEP 3000112..3000609 3000112 3000609 + 165 15609820 - Rv2683 COG0517R V nonessential hypothetical protein KEEP 3000610..3000613 3000610 3000613 I NA NA IG2727_Rv2683-Rv2684 KEEP 3000614..3001903 3000614 3000926 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA KEEP 3000614..3001903 3000927 3000997 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA Only Marin et al 2022 KEEP 3000614..3001903 3000998 3001075 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA KEEP 3000614..3001903 3001076 3001136 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA Only Marin et al 2022 KEEP 3000614..3001903 3001137 3001303 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA KEEP 3000614..3001903 3001304 3001385 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA Only Marin et al 2022 KEEP 3000614..3001903 3001386 3001420 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA KEEP 3000614..3001903 3001421 3001480 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA Only Marin et al 2022 KEEP 3000614..3001903 3001481 3001759 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA KEEP 3000614..3001903 3001760 3001811 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA Only Marin et al 2022 KEEP 3000614..3001903 3001812 3001903 + 429 15609821 arsA Rv2684 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsA KEEP 3001904..3001982 3001904 3001982 I NA NA IG2728_Rv2684-Rv2685 KEEP 3001983..3003269 3001983 3002295 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 KEEP 3001983..3003269 3002296 3002366 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 Only Marin et al 2022 KEEP 3001983..3003269 3002367 3002444 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 KEEP 3001983..3003269 3002445 3002505 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 Only Marin et al 2022 KEEP 3001983..3003269 3002506 3002672 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 KEEP 3001983..3003269 3002673 3002754 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 Only Marin et al 2022 KEEP 3001983..3003269 3002755 3002789 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 KEEP 3001983..3003269 3002790 3002849 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 Only Marin et al 2022 KEEP 3001983..3003269 3002850 3003128 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 KEEP 3001983..3003269 3003129 3003180 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 Only Marin et al 2022 KEEP 3001983..3003269 3003181 3003269 + 428 57117014 arsB1 Rv2685 COG1055P III.A.4 nonessential arsenic-transport integral membrane protein ArsB1 KEEP 3003270..3003279 3003270 3003279 I NA NA IG2729_Rv2685-Rv2686c KEEP 3003280..3004038 3003280 3004038 - 252 15609823 - Rv2686c - II.C.5 nonessential antibiotic ABC transporter transmembrane protein KEEP 3004035..3004748 3004035 3004748 - 237 15609824 - Rv2687c - II.C.5 nonessential antibiotic ABC transporter transmembrane protein KEEP 3004745..3005650 3004745 3005650 - 301 15609825 - Rv2688c COG1131V III.A nonessential antibiotic ABC transporter ATP-binding protein KEEP 3005651..3005844 3005651 3005844 I NA NA IG2732_Rv2688c-Rv2689c KEEP 3005845..3007062 3005845 3007031 - 405 15609826 - Rv2689c COG2265J V nonessential hypothetical protein KEEP 3005845..3007062 3007032 3007062 - 405 15609826 - Rv2689c COG2265J V nonessential hypothetical protein Only Marin et al 2022 KEEP 3007063..3007235 3007063 3007227 I NA NA IG2733_Rv2689c-Rv2690c Only Marin et al 2022 KEEP 3007063..3007235 3007228 3007235 I NA NA IG2733_Rv2689c-Rv2690c KEEP 3007236..3009209 3007236 3009209 - 657 15609827 - Rv2690c COG0531E II.C.5 nonessential hypothetical protein KEEP 3009210..3009343 3009210 3009343 I NA NA IG2734_Rv2690c-Rv2691 KEEP 3009344..3010027 3009344 3010027 + 227 57117015 ceoB Rv2691 COG0569P III.A.2 nonessential TRK system potassium uptake protein CEOB KEEP 3010024..3010686 3010024 3010686 + 220 57117016 ceoC Rv2692 COG0569P III.A.2 essential TRK system potassium uptake protein CEOC KEEP 3010687..3010696 3010687 3010696 I NA NA IG2736_Rv2692-Rv2693c KEEP 3010697..3011368 3010697 3011368 - 223 15609830 - Rv2693c - II.C.5 nonessential integral membrane alanine and leucine rich protein KEEP 3011369..3011398 3011369 3011398 I NA NA IG2737_Rv2693c-Rv2694c KEEP 3011399..3011767 3011399 3011767 - 122 15609831 - Rv2694c - V nonessential hypothetical protein KEEP 3011768..3011915 3011768 3011915 I NA NA IG2738_Rv2694c-Rv2695 KEEP 3011916..3012623 3011916 3012623 + 235 15609832 - Rv2695 - V nonessential hypothetical protein KEEP 3012624..3012828 3012624 3012828 I NA NA IG2739_Rv2695-Rv2696c KEEP 3012829..3013608 3012829 3013608 - 259 15609833 - Rv2696c COG1530J V essential hypothetical protein KEEP 3013609..3013682 3013609 3013682 I NA NA IG2740_Rv2696c-Rv2697c KEEP 3013683..3014147 3013683 3014147 - 154 15609834 dut Rv2697c COG0756F I.F.3 essential deoxyuridine 5'-triphosphate nucleotidohydrolase KEEP 3014148..3014172 3014148 3014172 I NA NA IG2741_Rv2697c-Rv2698 KEEP 3014173..3014658 3014173 3014658 + 161 15609835 - Rv2698 - II.C.5 essential alanine rich transmembrane protein KEEP 3014659..3014662 3014659 3014662 I NA NA IG2742_Rv2698-Rv2699c KEEP 3014663..3014965 3014663 3014965 - 100 15609836 - Rv2699c - V nonessential hypothetical protein KEEP 3014966..3015202 3014966 3015202 I NA NA IG2743_Rv2699c-Rv2700 KEEP 3015203..3015853 3015203 3015853 + 216 15609837 - Rv2700 - VI essential secreted alanine rich protein KEEP 3015854..3015862 3015854 3015862 I NA NA IG2744_Rv2700-Rv2701c KEEP 3015863..3016735 3015863 3016735 - 290 15609838 suhB Rv2701c COG0483G III.B nonessential extragenic suppressor protein SuhB KEEP 3016736..3016857 3016736 3016857 I NA NA IG2745_Rv2701c-Rv2702 KEEP 3016858..3017655 3016858 3017655 + 265 15609839 ppgK Rv2702 COG1940KG I.A.1 essential polyphosphate glucokinase PPGK (polyphosphate-glucose phosphotransferase) KEEP 3017656..3017834 3017656 3017834 I NA NA IG2746_Rv2702-Rv2703 KEEP 3017835..3019421 3017835 3018716 + 528 15609840 sigA Rv2703 COG0568K II.A.7 essential RNA polymerase sigma factor KEEP 3017835..3019421 3018717 3018767 + 528 15609840 sigA Rv2703 COG0568K II.A.7 essential RNA polymerase sigma factor Only Marin et al 2022 KEEP 3017835..3019421 3018768 3018794 + 528 15609840 sigA Rv2703 COG0568K II.A.7 essential RNA polymerase sigma factor KEEP 3017835..3019421 3018795 3018854 + 528 15609840 sigA Rv2703 COG0568K II.A.7 essential RNA polymerase sigma factor Only Marin et al 2022 KEEP 3017835..3019421 3018855 3019421 + 528 15609840 sigA Rv2703 COG0568K II.A.7 essential RNA polymerase sigma factor KEEP 3019422..3019457 3019422 3019457 I NA NA IG2747_Rv2703-Rv2704 KEEP 3019458..3019886 3019458 3019886 + 142 15609841 - Rv2704 COG0251J V nonessential hypothetical protein KEEP 3019814..3020203 3019814 3020203 - 129 15609842 - Rv2705c COG3502S V nonessential hypothetical protein KEEP 3020200..3020457 3020200 3020457 - 85 15609843 - Rv2706c - VI nonessential hypothetical protein KEEP 3020458..3020572 3020458 3020572 I NA NA IG2750_Rv2706c-Rv2707 KEEP 3020573..3021547 3020573 3021547 + 324 15609844 - Rv2707 COG1295S II.C.5 essential hypothetical protein KEEP 3021548..3021796 3021548 3021796 - 82 15609845 - Rv2708c - V nonessential hypothetical protein KEEP 3021797..3021838 3021797 3021838 I NA NA IG2752_Rv2708c-Rv2709 KEEP 3021839..3022285 3021839 3022285 + 148 15609846 - Rv2709 - II.C.5 nonessential transmembrane protein KEEP 3022286..3022460 3022286 3022460 I NA NA IG2753_Rv2709-Rv2710 KEEP 3022461..3023432 3022461 3022727 + 323 15609847 sigB Rv2710 COG0568K II.A.7 essential RNA polymerase sigma factor SigB KEEP 3022461..3023432 3022728 3022778 + 323 15609847 sigB Rv2710 COG0568K II.A.7 essential RNA polymerase sigma factor SigB Only Marin et al 2022 KEEP 3022461..3023432 3022779 3022805 + 323 15609847 sigB Rv2710 COG0568K II.A.7 essential RNA polymerase sigma factor SigB KEEP 3022461..3023432 3022806 3022865 + 323 15609847 sigB Rv2710 COG0568K II.A.7 essential RNA polymerase sigma factor SigB Only Marin et al 2022 KEEP 3022461..3023432 3022866 3023432 + 323 15609847 sigB Rv2710 COG0568K II.A.7 essential RNA polymerase sigma factor SigB KEEP 3023433..3023564 3023433 3023564 I NA NA IG2754_Rv2710-Rv2711 KEEP 3023565..3024257 3023565 3024257 + 230 15609848 ideR Rv2711 COG1321K I.J.1 nonessential IRON-dependent repressor and activator IDER KEEP 3024258..3024269 3024258 3024269 I NA NA IG2755_Rv2711-Rv2712c KEEP 3024270..3025328 3024270 3025328 - 352 15609849 - Rv2712c - VI nonessential hypothetical protein KEEP 3025329..3025440 3025329 3025440 I NA NA IG2756_Rv2712c-Rv2713 KEEP 3025441..3026847 3025441 3026261 + 468 15609850 sthA Rv2713 COG1249C I.B.7 nonessential soluble pyridine nucleotide transhydrogenase KEEP 3025441..3026847 3026262 3026284 + 468 15609850 sthA Rv2713 COG1249C I.B.7 nonessential soluble pyridine nucleotide transhydrogenase Only Marin et al 2022 KEEP 3025441..3026847 3026285 3026847 + 468 15609850 sthA Rv2713 COG1249C I.B.7 nonessential soluble pyridine nucleotide transhydrogenase KEEP 3026848..3027064 3026848 3027064 I NA NA IG2757_Rv2713-Rv2714 KEEP 3027065..3028039 3027065 3028039 + 324 15609851 - Rv2714 - V nonessential hypothetical protein KEEP 3028040..3028097 3028040 3028097 I NA NA IG2758_Rv2714-Rv2715 KEEP 3028098..3029123 3028098 3029123 + 341 15609852 - Rv2715 COG0596R II.B.6 nonessential hydrolase KEEP 3029124..3029171 3029124 3029171 I NA NA IG2759_Rv2715-Rv2716 KEEP 3029172..3029858 3029172 3029858 + 228 15609853 - Rv2716 COG0384R V nonessential hypothetical protein KEEP 3029859..3029866 3029859 3029866 I NA NA IG2760_Rv2716-Rv2717c KEEP 3029867..3030361 3029867 3030361 - 164 15609854 - Rv2717c - V nonessential hypothetical protein KEEP 3030362..3030412 3030362 3030412 I NA NA IG2761_Rv2717c-Rv2718c KEEP 3030413..3030877 3030413 3030877 - 154 15609855 - Rv2718c COG1327K V nonessential transcriptional regulator NrdR KEEP 3030878..3031039 3030878 3031039 I NA NA IG2762_Rv2718c-Rv2719c KEEP 3031040..3031537 3031040 3031537 - 165 15609856 - Rv2719c COG0739M II.C.5 nonessential hypothetical protein KEEP 3031538..3031844 3031538 3031844 I NA NA IG2763_Rv2719c-Rv2720 KEEP 3031845..3032498 3031845 3032498 + 217 15609857 lexA Rv2720 COG1974KT I.J.1 nonessential LexA repressor KEEP 3032499..3032519 3032499 3032519 I NA NA IG2764_Rv2720-Rv2721c KEEP 3032520..3034619 3032520 3034619 - 699 15609858 - Rv2721c COG5479M II.C.5 nonessential hypothetical protein KEEP 3034620..3034634 3034620 3034634 I NA NA IG2765_Rv2721c-Rv2722 KEEP 3034635..3034883 3034635 3034883 + 82 15609859 - Rv2722 - V nonessential hypothetical protein KEEP 3034884..3034908 3034884 3034908 I NA NA IG2766_Rv2722-Rv2723 KEEP 3034909..3036102 3034909 3036102 + 397 15609860 - Rv2723 COG0861P III.A.2 nonessential integral membrane protein KEEP 3036103..3036130 3036103 3036130 I NA NA IG2767_Rv2723-Rv2724c KEEP 3036131..3037291 3036131 3037291 - 386 15609861 fadE20 Rv2724c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE20 KEEP 3037292..3037426 3037292 3037426 I NA NA IG2768_Rv2724c-Rv2725c KEEP 3037427..3038914 3037427 3038914 - 495 15609862 hflX Rv2725c COG2262R II.B.3 nonessential GTP-binding protein HflX KEEP 3038915..3038930 3038915 3038930 I NA NA IG2769_Rv2725c-Rv2726c KEEP 3038931..3039800 3038931 3039800 - 289 15609863 dapF Rv2726c COG0253E I.D.2 essential diaminopimelate epimerase KEEP 3039801..3039824 3039801 3039824 I NA NA IG2770_Rv2726c-Rv2727c KEEP 3039825..3040769 3039825 3040769 - 314 15609864 miaA Rv2727c COG0324J I.F.5 essential tRNA delta(2)-isopentenylpyrophosphate transferase KEEP 3040766..3041461 3040766 3041461 - 231 15609865 - Rv2728c - V nonessential hypothetical protein KEEP 3041462..3041569 3041462 3041569 I NA NA IG2772_Rv2728c-Rv2729c KEEP 3041570..3042475 3041570 3042475 - 301 15609866 - Rv2729c COG0697GER II.C.5 nonessential hypothetical protein KEEP 3042476..3042541 3042476 3042541 I NA NA IG2773_Rv2729c-Rv2730 KEEP 3042542..3043018 3042542 3043018 + 158 15609867 - Rv2730 - VI nonessential hypothetical protein KEEP 3043019..3043025 3043019 3043025 I NA NA IG2774_Rv2730-Rv2731 KEEP 3043026..3044378 3043026 3044378 + 450 15609868 - Rv2731 - V nonessential hypothetical protein KEEP 3044375..3044989 3044375 3044989 - 204 15609869 - Rv2732c - II.C.5 nonessential transmembrane protein KEEP 3044986..3046524 3044986 3046524 - 512 15609870 - Rv2733c COG0621J V nonessential hypothetical protein KEEP 3046525..3046820 3046525 3046820 I NA NA IG2777_Rv2733c-Rv2734 KEEP 3046821..3047675 3046821 3047675 + 284 15609871 - Rv2734 COG4422S V essential hypothetical protein KEEP 3047560..3048552 3047560 3048552 - 330 15609872 - Rv2735c - V nonessential hypothetical protein KEEP 3048553..3048561 3048553 3048561 I NA NA IG2779_Rv2735c-Rv2736c KEEP 3048562..3049086 3048562 3049086 - 174 15609873 recX Rv2736c COG2137R II.A.5 nonessential recombination regulator RecX KEEP 3049052..3051424 3049052 3051424 - 790 15609874 recA Rv2737c COG0468L,COG1372L V nonessential recombinase A KEEP 3051425..3051618 3051425 3051618 I NA NA IG2781_Rv2737c-Rv2737A KEEP 3051619..3051792 3051619 3051792 + 57 57117017 - Rv2737A - II.A.5 nonessential hypothetical protein KEEP 3051793..3051805 3051793 3051805 I NA NA IG2782_Rv2737A-Rv2738c KEEP 3051806..3052012 3051806 3052012 - 68 15609875 - Rv2738c - V nonessential hypothetical protein KEEP 3052013..3052022 3052013 3052022 I NA NA IG2783_Rv2738c-Rv2739c KEEP 3052023..3053189 3052023 3053189 - 388 15609876 - Rv2739c COG1819GC IV.H essential alanine rich transferase KEEP 3053190..3053232 3053190 3053232 I NA NA IG2784_Rv2739c-Rv2740 KEEP 3053233..3053682 3053233 3053682 + 149 15609877 - Rv2740 COG4308Q V nonessential hypothetical protein KEEP 3053683..3053913 3053683 3053913 I NA NA IG2785_Rv2740-Rv2741 KEEP 3053914..3055491 3053914 3054575 + 525 57117018 PE_PGRS47 Rv2741 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3053914..3055491 3054576 3054941 + 525 57117018 PE_PGRS47 Rv2741 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3053914..3055491 3054942 3054951 + 525 57117018 PE_PGRS47 Rv2741 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3053914..3055491 3054952 3055236 + 525 57117018 PE_PGRS47 Rv2741 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3053914..3055491 3055237 3055491 + 525 57117018 PE_PGRS47 Rv2741 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3055492..3055514 3055492 3055514 I NA NA IG2786_Rv2741-Rv2742c KEEP 3055515..3056348 3055515 3056348 - 277 15609879 - Rv2742c - V nonessential hypothetical protein KEEP 3056349..3056419 3056349 3056419 I NA NA IG2787_Rv2742c-Rv2743c KEEP 3056420..3057232 3056420 3057232 - 270 15609880 - Rv2743c - II.C.5 nonessential hypothetical protein KEEP 3057233..3057250 3057233 3057250 I NA NA IG2788_Rv2743c-Rv2744c KEEP 3057251..3058063 3057251 3058063 - 270 57117019 35kd_ag Rv2744c COG1842KT VI nonessential hypothetical protein KEEP 3058064..3058192 3058064 3058192 I NA NA IG2789_Rv2744c-Rv2745c KEEP 3058193..3058531 3058193 3058531 - 112 15609882 - Rv2745c COG1396K I.J.1 nonessential transcriptional regulatory protein KEEP 3058532..3058601 3058532 3058601 I NA NA IG2790_Rv2745c-Rv2746c KEEP 3058602..3059231 3058602 3059231 - 209 15609883 pgsA3 Rv2746c COG0558I I.H.3 essential CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase KEEP 3059232..3059261 3059232 3059261 I NA NA IG2791_Rv2746c-Rv2747 KEEP 3059262..3059786 3059262 3059786 + 174 15609884 - Rv2747 COG1246E IV.H essential N-acetylglutamate synthase KEEP 3059787..3059854 3059787 3059791 I NA NA IG2792_Rv2747-Rv2748c KEEP 3059787..3059854 3059792 3059850 I NA NA IG2792_Rv2747-Rv2748c Marin et al 2022 + homoplasy analysis DISCARD 3059787..3059854 3059851 3059854 I NA NA IG2792_Rv2747-Rv2748c KEEP 3059855..3062506 3059855 3062506 - 883 15609885 ftsK Rv2748c COG1674D III.C essential cell division transmembrane protein FtsK KEEP 3062505..3062819 3062505 3062819 + 104 15609886 - Rv2749 COG1359S V nonessential hypothetical protein KEEP 3062816..3063634 3062816 3063634 + 272 15609887 - Rv2750 COG1028IQR VI nonessential 3-ketoacyl-(acyl-carrier-protein) reductase KEEP 3063635..3063637 3063635 3063637 I NA NA IG2795_Rv2750-Rv2751 KEEP 3063638..3064528 3063638 3064528 + 296 15609888 - Rv2751 COG3315Q V nonessential hypothetical protein KEEP 3064515..3066191 3064515 3066191 - 558 15609889 - Rv2752c COG0595R V nonessential hypothetical protein KEEP 3066192..3066221 3066192 3066221 I NA NA IG2797_Rv2752c-Rv2753c KEEP 3066222..3067124 3066222 3067124 - 300 15609890 dapA Rv2753c COG0329EM I.D.2 essential dihydrodipicolinate synthase KEEP 3067125..3067192 3067125 3067192 I NA NA IG2798_Rv2753c-Rv2754c KEEP 3067193..3067945 3067193 3067945 - 250 15609891 thyX Rv2754c COG1351F VII essential FAD-dependent thymidylate synthase KEEP 3067946..3068188 3067946 3068188 I NA NA IG2799_Rv2754c-Rv2755c KEEP 3068189..3068464 3068189 3068464 - 91 57117020 hsdS.1 Rv2755c COG0732V II.A.5 nonessential type I restriction/modification system specificity determinant HsdS KEEP 3068461..3070083 3068461 3070083 - 540 15609893 hsdM Rv2756c COG0286V II.A.5 nonessential type I restriction/modification system DNA methylase HsdM KEEP 3070084..3070169 3070084 3070169 I NA NA IG2801_Rv2756c-Rv2757c KEEP 3070170..3070586 3070170 3070586 - 138 15609894 - Rv2757c COG1487R V nonessential hypothetical protein KEEP 3070583..3070849 3070583 3070849 - 88 15609895 - Rv2758c - V nonessential hypothetical protein KEEP 3070850..3070874 3070850 3070874 I NA NA IG2803_Rv2758c-Rv2759c KEEP 3070875..3071270 3070875 3071270 - 131 15609896 - Rv2759c COG3742S V nonessential hypothetical protein KEEP 3071267..3071536 3071267 3071536 - 89 15609897 - Rv2760c - V nonessential hypothetical protein KEEP 3071537..3071545 3071537 3071545 I NA NA IG2805_Rv2760c-Rv2761c KEEP 3071546..3072640 3071546 3072640 - 364 15609898 hsdS Rv2761c COG0732V VII nonessential type I restriction/modification system specificity determinant HsdS KEEP 3072637..3073056 3072637 3073056 - 139 15609899 - Rv2762c COG3214S V nonessential hypothetical protein KEEP 3073057..3073129 3073057 3073061 I NA NA IG2807_Rv2762c-Rv2763c KEEP 3073057..3073129 3073062 3073129 I NA NA IG2807_Rv2762c-Rv2763c Only Marin et al 2022 KEEP 3073130..3073609 3073130 3073136 - 159 15609900 dfrA Rv2763c COG0262H I.G.2 nonessential dihydrofolate reductase DFRA (DHFR) (tetrahydrofolate dehydrogenase) Only Marin et al 2022 KEEP 3073130..3073609 3073137 3073609 - 159 15609900 dfrA Rv2763c COG0262H I.G.2 nonessential dihydrofolate reductase DFRA (DHFR) (tetrahydrofolate dehydrogenase) KEEP 3073610..3073679 3073610 3073679 I NA NA IG2808_Rv2763c-Rv2764c KEEP 3073680..3074471 3073680 3074471 - 263 15609901 thyA Rv2764c COG0207F I.F.3 DR-pas nonessential thymidylate synthase KEEP 3074472..3074635 3074472 3074635 I NA NA IG2809_Rv2764c-Rv2765 KEEP 3074636..3075373 3074636 3075373 + 245 15609902 - Rv2765 COG0412Q IV.I nonessential hypothetical protein KEEP 3075374..3075587 3075374 3075587 I NA NA IG2810_Rv2765-Rv2766c KEEP 3075588..3076370 3075588 3076370 - 260 57117021 fabG Rv2766c COG1028IQR I.H.1 nonessential 3-ketoacyl-(acyl-carrier-protein) reductase KEEP 3076367..3076720 3076367 3076720 - 117 15609904 - Rv2767c - II.C.5 nonessential hypothetical protein KEEP 3076721..3076893 3076721 3076893 I NA NA IG2812_Rv2767c-Rv2768c KEEP 3076894..3078078 3076894 3076897 - 394 57117022 PPE43 Rv2768c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3076894..3078078 3076898 3076962 - 394 57117022 PPE43 Rv2768c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3076894..3078078 3076963 3078078 - 394 57117022 PPE43 Rv2768c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3078079..3078157 3078079 3078157 I NA NA IG2813_Rv2768c-Rv2769c repeat KEEP 3078158..3078985 3078158 3078167 - 275 57117023 PE27 Rv2769c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 3078158..3078985 3078168 3078218 - 275 57117023 PE27 Rv2769c - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 3078158..3078985 3078219 3078985 - 275 57117023 PE27 Rv2769c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 3078986..3079308 3078986 3079308 I NA NA IG2814_Rv2769c-Rv2770c repeat KEEP 3079309..3080457 3079309 3080457 - 382 57117024 PPE44 Rv2770c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3080458..3080580 3080458 3080580 I NA NA IG2815_Rv2770c-Rv2771c KEEP 3080581..3081033 3080581 3081033 - 150 15609908 - Rv2771c COG0655R V nonessential hypothetical protein KEEP 3081034..3081118 3081034 3081118 I NA NA IG2816_Rv2771c-Rv2772c KEEP 3081119..3081592 3081119 3081592 - 157 15609909 - Rv2772c - II.C.5 nonessential transmembrane protein KEEP 3081593..3081603 3081593 3081603 I NA NA IG2817_Rv2772c-Rv2773c KEEP 3081604..3082341 3081604 3082341 - 245 15609910 dapB Rv2773c COG0289E I.D.2 nonessential dihydrodipicolinate reductase KEEP 3082342..3082351 3082342 3082351 I NA NA IG2818_Rv2773c-Rv2774c KEEP 3082352..3082756 3082352 3082461 - 134 15609911 - Rv2774c - VI nonessential hypothetical protein KEEP 3082352..3082756 3082462 3082661 - 134 15609911 - Rv2774c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 3082352..3082756 3082662 3082703 - 134 15609911 - Rv2774c - VI nonessential hypothetical protein KEEP 3082352..3082756 3082704 3082756 - 134 15609911 - Rv2774c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 3082757..3082908 3082757 3082763 I NA NA IG2819_Rv2774c-Rv2775 Only Marin et al 2022 KEEP 3082757..3082908 3082764 3082908 I NA NA IG2819_Rv2774c-Rv2775 KEEP 3082909..3083370 3082909 3083370 + 153 15609912 - Rv2775 COG0454KR VI nonessential hypothetical protein KEEP 3083371..3083373 3083371 3083373 I NA NA IG2820_Rv2775-Rv2776c KEEP 3083374..3084303 3083374 3084303 - 309 15609913 - Rv2776c COG1018C I.B.7 nonessential oxidoreductase KEEP 3084304..3084484 3084304 3084484 I NA NA IG2821_Rv2776c-Rv2777c KEEP 3084485..3085555 3084485 3085555 - 356 15609914 - Rv2777c COG3687R V nonessential hypothetical protein KEEP 3085556..3085712 3085556 3085712 I NA NA IG2822_Rv2777c-Rv2778c KEEP 3085713..3086183 3085713 3086183 - 156 15609915 - Rv2778c - V nonessential hypothetical protein KEEP 3086184..3086214 3086184 3086214 I NA NA IG2823_Rv2778c-Rv2779c KEEP 3086215..3086754 3086215 3086754 - 179 57117025 - Rv2779c COG1522K I.J.1 nonessential LRP/AsnC family transcriptional regulator KEEP 3086755..3086819 3086755 3086819 I NA NA IG2824_Rv2779c-Rv2780 KEEP 3086820..3087935 3086820 3087935 + 371 15609917 ald Rv2780 COG0686E I.A.2 nonessential secreted L-alanine dehydrogenase ALD (40 kDa antigen) (TB43) KEEP 3087936..3087949 3087936 3087949 I NA NA IG2825_Rv2780-Rv2781c KEEP 3087950..3088984 3087950 3088984 - 344 15609918 - Rv2781c COG2070R I.B.7 nonessential alanine rich oxidoreductase KEEP 3088985..3089044 3088985 3089044 I NA NA IG2826_Rv2781c-Rv2782c KEEP 3089045..3090361 3089045 3090361 - 438 15609919 pepR Rv2782c COG0612R II.B.3 nonessential zinc protease PEPR KEEP 3090339..3092597 3090339 3092597 - 752 15609920 gpsI Rv2783c COG1185J II.A.7 nonessential polynucleotide phosphorylase/polyadenylase KEEP 3092598..3092950 3092598 3092950 I NA NA IG2828_Rv2783c-Rv2784c KEEP 3092951..3093466 3092951 3093466 - 171 15609921 lppU Rv2784c - II.C.1 nonessential lipoprotein LppU KEEP 3093467..3093478 3093467 3093478 I NA NA IG2829_Rv2784c-Rv2785c KEEP 3093479..3093748 3093479 3093748 - 89 15609922 rpsO Rv2785c COG0184J II.A.1 nonessential 30S ribosomal protein S15 KEEP 3093749..3093904 3093749 3093904 I NA NA IG2830_Rv2785c-Rv2786c KEEP 3093905..3094900 3093905 3094900 - 331 15609923 ribF Rv2786c COG0196H I.G.9 essential bifunctional riboflavin kinase/FMN adenylyltransferase KEEP 3094901..3095110 3094901 3095110 I NA NA IG2831_Rv2786c-Rv2787 KEEP 3095111..3096874 3095111 3096874 + 587 15609924 - Rv2787 COG0455D V nonessential hypothetical protein KEEP 3096875..3096958 3096875 3096958 I NA NA IG2832_Rv2787-Rv2788 KEEP 3096959..3097645 3096959 3097645 + 228 15609925 sirR Rv2788 COG1321K I.J.1 nonessential transcriptional repressor SIRR KEEP 3097646..3097705 3097646 3097653 I NA NA IG2833_Rv2788-Rv2789c KEEP 3097646..3097705 3097654 3097705 I NA NA IG2833_Rv2788-Rv2789c Only Marin et al 2022 KEEP 3097706..3098938 3097706 3097715 - 410 15609926 fadE21 Rv2789c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE21 Only Marin et al 2022 KEEP 3097706..3098938 3097716 3098938 - 410 15609926 fadE21 Rv2789c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE21 KEEP 3098939..3098963 3098939 3098963 I NA NA IG2834_Rv2789c-Rv2790c KEEP 3098964..3100169 3098964 3100169 - 401 15609927 ltp1 Rv2790c COG0183I III.A.5 nonessential lipid-transfer protein KEEP 3100170..3100201 3100170 3100201 I NA NA IG2835_Rv2790c-Rv2791c Annotation + Marin et al 2022 DISCARD 3100202..3101581 3100202 3100401 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3100202..3101581 3100402 3100445 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase KEEP 3100202..3101581 3100446 3100511 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3100202..3101581 3100512 3100514 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase KEEP 3100202..3101581 3100515 3100571 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3100202..3101581 3100572 3100693 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase KEEP 3100202..3101581 3100694 3100799 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3100202..3101581 3100800 3100878 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase KEEP 3100202..3101581 3100879 3100939 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3100202..3101581 3100940 3100964 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase KEEP 3100202..3101581 3100965 3101132 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3100202..3101581 3101133 3101234 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase KEEP 3100202..3101581 3101235 3101377 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3100202..3101581 3101378 3101428 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase KEEP 3100202..3101581 3101429 3101543 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3100202..3101581 3101544 3101581 - 459 15609928 - Rv2791c COG0675L IV.B.1 phage nonessential transposase KEEP 3101581..3102162 3101581 3101659 - 193 15609929 - Rv2792c COG2452L IV.B.1 nonessential resolvase KEEP 3101581..3102162 3101660 3101731 - 193 15609929 - Rv2792c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3101581..3102162 3101732 3101860 - 193 15609929 - Rv2792c COG2452L IV.B.1 nonessential resolvase KEEP 3101581..3102162 3101861 3101911 - 193 15609929 - Rv2792c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3101581..3102162 3101912 3102098 - 193 15609929 - Rv2792c COG2452L IV.B.1 nonessential resolvase KEEP 3101581..3102162 3102099 3102162 - 193 15609929 - Rv2792c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3102163..3102363 3102163 3102229 I NA NA IG2837_Rv2792c-Rv2793c Only Marin et al 2022 KEEP 3102163..3102363 3102230 3102339 I NA NA IG2837_Rv2792c-Rv2793c KEEP 3102163..3102363 3102340 3102363 I NA NA IG2837_Rv2792c-Rv2793c Only Marin et al 2022 KEEP 3102364..3103260 3102364 3102390 - 298 15609930 truB Rv2793c COG0130J II.A.7 nonessential tRNA pseudouridine synthase B Only Marin et al 2022 KEEP 3102364..3103260 3102391 3103260 - 298 15609930 truB Rv2793c COG0130J II.A.7 nonessential tRNA pseudouridine synthase B KEEP 3103257..3103940 3103257 3103940 - 227 15609931 - Rv2794c COG2977Q V nonessential hypothetical protein KEEP 3103937..3104911 3103937 3104911 - 324 15609932 - Rv2795c COG1409R V nonessential hypothetical protein KEEP 3104912..3105055 3104912 3104975 I NA NA IG2840_Rv2795c-Rv2796c KEEP 3104912..3105055 3104976 3105044 I NA NA IG2840_Rv2795c-Rv2796c Only Marin et al 2022 KEEP 3104912..3105055 3105045 3105055 I NA NA IG2840_Rv2795c-Rv2796c KEEP 3105056..3105619 3105056 3105619 - 187 15609933 lppV Rv2796c - II.C.1 nonessential lipoprotein LppV KEEP 3105619..3107307 3105619 3107307 - 562 15609934 - Rv2797c - V nonessential hypothetical protein KEEP 3107308..3107310 3107308 3107310 I NA NA IG2842_Rv2797c-Rv2798c KEEP 3107311..3107637 3107311 3107637 - 108 15609935 - Rv2798c - V nonessential hypothetical protein KEEP 3107638..3107767 3107638 3107767 I NA NA IG2843_Rv2798c-Rv2799 KEEP 3107768..3108397 3107768 3108397 + 209 15609936 - Rv2799 - II.C.5 nonessential hypothetical protein KEEP 3108398..3108415 3108398 3108415 I NA NA IG2844_Rv2799-Rv2800 KEEP 3108416..3110065 3108416 3110065 + 549 15609937 - Rv2800 COG2936R IV.I nonessential hydrolase KEEP 3110066..3110166 3110066 3110166 I NA NA IG2845_Rv2800-Rv2801c KEEP 3110167..3110523 3110167 3110523 - 118 15609938 - Rv2801c COG2337T V nonessential hypothetical protein KEEP 3110524..3110779 3110524 3110779 I NA NA IG2846_Rv2801c-Rv2802c KEEP 3110780..3111823 3110780 3111823 - 347 15609939 - Rv2802c COG5586S VI nonessential hypothetical protein KEEP 3111822..3112289 3111822 3112289 + 155 57117026 - Rv2803 COG4453S V nonessential hypothetical protein KEEP 3112290..3112464 3112290 3112311 I NA NA IG2848_Rv2803-Rv2804c KEEP 3112290..3112464 3112312 3112313 I NA NA IG2848_Rv2803-Rv2804c Only Marin et al 2022 KEEP 3112290..3112464 3112314 3112458 I NA NA IG2848_Rv2803-Rv2804c KEEP 3112290..3112464 3112459 3112460 I NA NA IG2848_Rv2803-Rv2804c Only Marin et al 2022 KEEP 3112290..3112464 3112461 3112464 I NA NA IG2848_Rv2803-Rv2804c KEEP 3112465..3113094 3112465 3113016 - 209 15609941 - Rv2804c - VI nonessential hypothetical protein KEEP 3112465..3113094 3113017 3113094 - 209 15609941 - Rv2804c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 3112867..3113271 3112867 3113016 + 134 15609942 - Rv2805 - V nonessential hypothetical protein KEEP 3112867..3113271 3113017 3113104 + 134 15609942 - Rv2805 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3112867..3113271 3113105 3113271 + 134 15609942 - Rv2805 - V nonessential hypothetical protein KEEP 3113268..3113459 3113268 3113459 + 63 15609943 - Rv2806 - II.C.5 nonessential hypothetical protein KEEP 3113460..3113657 3113460 3113657 I NA NA IG2851_Rv2806-Rv2807 KEEP 3113658..3114812 3113658 3113774 + 384 15609944 - Rv2807 - V nonessential hypothetical protein KEEP 3113658..3114812 3113775 3113862 + 384 15609944 - Rv2807 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3113658..3114812 3113863 3114812 + 384 15609944 - Rv2807 - V nonessential hypothetical protein KEEP 3114813..3115045 3114813 3115045 I NA NA IG2852_Rv2807-Rv2808 KEEP 3115046..3115303 3115046 3115303 + 85 15609945 - Rv2808 - VI essential hypothetical protein KEEP 3115304..3115407 3115304 3115407 I NA NA IG2853_Rv2808-Rv2809 KEEP 3115408..3115719 3115408 3115719 + 103 15609946 - Rv2809 - VI nonessential hypothetical protein KEEP 3115720..3115740 3115720 3115740 I NA NA IG2854_Rv2809-Rv2810c KEEP 3115741..3116142 3115741 3116142 - 133 15609947 - Rv2810c COG3464L IV.B.1 phage nonessential transposase KEEP 3116139..3116747 3116139 3116413 + 202 15609948 - Rv2811 - V nonessential hypothetical protein KEEP 3116139..3116747 3116414 3116522 + 202 15609948 - Rv2811 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3116139..3116747 3116523 3116681 + 202 15609948 - Rv2811 - V nonessential hypothetical protein KEEP 3116139..3116747 3116682 3116747 + 202 15609948 - Rv2811 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3116748..3116817 3116748 3116766 I NA NA IG2856_Rv2811-Rv2812 Annotation + Marin et al 2022 DISCARD 3116748..3116817 3116767 3116817 I NA NA IG2856_Rv2811-Rv2812 KEEP 3116818..3118227 3116818 3116842 + 469 15609949 - Rv2812 COG2801L IV.B.1 phage essential transposase KEEP 3116818..3118227 3116843 3116989 + 469 15609949 - Rv2812 COG2801L IV.B.1 phage essential transposase Annotation + Marin et al 2022 DISCARD 3116818..3118227 3116990 3118227 + 469 15609949 - Rv2812 COG2801L IV.B.1 phage essential transposase KEEP 3118224..3119036 3118224 3119036 + 270 15609950 - Rv2813 COG3267U III.D essential hypothetical protein KEEP 3119037..3120565 3119037 3119559 I NA NA IG2858_Rv2813-Rv2814c KEEP 3119037..3120565 3119560 3119563 I NA NA IG2858_Rv2813-Rv2814c Annotation + Marin et al 2022 DISCARD 3119037..3120565 3119564 3119565 I NA NA IG2858_Rv2813-Rv2814c KEEP 3119037..3120565 3119566 3120565 I NA NA IG2858_Rv2813-Rv2814c Annotation + Marin et al 2022 DISCARD 3120566..3121504 3120566 3121504 - 312 15609951 - Rv2814c COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3121501..3121827 3121501 3121827 - 108 15609952 - Rv2815c COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3121828..3123624 3121828 3122702 I NA NA IG2860_Rv2815c-Rv2816c Annotation + Marin et al 2022 DISCARD 3121828..3123624 3122703 3122802 I NA NA IG2860_Rv2815c-Rv2816c KEEP 3121828..3123624 3122803 3122918 I NA NA IG2860_Rv2815c-Rv2816c Annotation + Marin et al 2022 DISCARD 3121828..3123624 3122919 3122930 I NA NA IG2860_Rv2815c-Rv2816c KEEP 3121828..3123624 3122931 3122942 I NA NA IG2860_Rv2815c-Rv2816c Annotation + Marin et al 2022 DISCARD 3121828..3123624 3122943 3122947 I NA NA IG2860_Rv2815c-Rv2816c Annotation + homoplasy analysis DISCARD 3121828..3123624 3122948 3122954 I NA NA IG2860_Rv2815c-Rv2816c Annotation + Marin et al 2022 DISCARD 3121828..3123624 3122955 3123026 I NA NA IG2860_Rv2815c-Rv2816c Annotation + homoplasy analysis DISCARD 3121828..3123624 3123027 3123283 I NA NA IG2860_Rv2815c-Rv2816c Annotation + Marin et al 2022 DISCARD 3121828..3123624 3123284 3123315 I NA NA IG2860_Rv2815c-Rv2816c Annotation + homoplasy analysis DISCARD 3121828..3123624 3123316 3123353 I NA NA IG2860_Rv2815c-Rv2816c Annotation + Marin et al 2022 DISCARD 3121828..3123624 3123354 3123421 I NA NA IG2860_Rv2815c-Rv2816c KEEP 3121828..3123624 3123422 3123424 I NA NA IG2860_Rv2815c-Rv2816c Annotation + Marin et al 2022 DISCARD 3121828..3123624 3123425 3123624 I NA NA IG2860_Rv2815c-Rv2816c KEEP 3123625..3123966 3123625 3123966 - 113 15609953 - Rv2816c COG1343L V nonessential hypothetical protein KEEP 3123967..3124983 3123967 3124983 - 338 15609954 - Rv2817c COG1518L V essential hypothetical protein KEEP 3124984..3124995 3124984 3124995 I NA NA IG2862_Rv2817c-Rv2818c KEEP 3124996..3126144 3124996 3126144 - 382 15609955 - Rv2818c - VI nonessential hypothetical protein KEEP 3126145..3126239 3126145 3126239 I NA NA IG2863_Rv2818c-Rv2819c KEEP 3126240..3127367 3126240 3127367 - 375 15609956 - Rv2819c COG1332L VI nonessential hypothetical protein KEEP 3127364..3128272 3127364 3128272 - 302 15609957 - Rv2820c COG1567L VI nonessential hypothetical protein KEEP 3128253..3128963 3128253 3128963 - 236 15609958 - Rv2821c COG1337L V nonessential hypothetical protein KEEP 3128964..3128972 3128964 3128972 I NA NA IG2866_Rv2821c-Rv2822c KEEP 3128973..3129347 3128973 3129347 - 124 15609959 - Rv2822c - VI nonessential hypothetical protein KEEP 3129344..3131773 3129344 3131773 - 809 15609960 - Rv2823c COG1353R V nonessential hypothetical protein KEEP 3131770..3132714 3131770 3132714 - 314 15609961 - Rv2824c COG5551S VI nonessential hypothetical protein KEEP 3132715..3132891 3132715 3132886 I NA NA IG2869_Rv2824c-Rv2825c KEEP 3132715..3132891 3132887 3132891 I NA NA IG2869_Rv2824c-Rv2825c Only Marin et al 2022 KEEP 3132892..3133539 3132892 3133461 - 215 15609962 - Rv2825c COG4293S V nonessential hypothetical protein Only Marin et al 2022 KEEP 3132892..3133539 3133462 3133539 - 215 15609962 - Rv2825c COG4293S V nonessential hypothetical protein KEEP 3133540..3133708 3133540 3133708 I NA NA IG2870_Rv2825c-Rv2826c KEEP 3133709..3134593 3133709 3134593 - 294 15609963 - Rv2826c COG2253S VI nonessential hypothetical protein KEEP 3134594..3134595 3134594 3134595 I NA NA IG2871_Rv2826c-Rv2827c KEEP 3134596..3135483 3134596 3135483 - 295 15609964 - Rv2827c COG0172J VI essential hypothetical protein KEEP 3135484..3135787 3135484 3135782 I NA NA IG2872_Rv2827c-Rv2828c KEEP 3135484..3135787 3135783 3135787 I NA NA IG2872_Rv2827c-Rv2828c Only Marin et al 2022 KEEP 3135788..3136333 3135788 3136333 - 181 15609965 - Rv2828c COG4293S V essential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 3136334..3136619 3136334 3136357 I NA NA IG2873_Rv2828c-Rv2829c Only Marin et al 2022 KEEP 3136334..3136619 3136358 3136619 I NA NA IG2873_Rv2828c-Rv2829c KEEP 3136620..3137012 3136620 3137012 - 130 15609966 - Rv2829c COG3744S V nonessential hypothetical protein KEEP 3137009..3137224 3137009 3137224 - 71 15609967 - Rv2830c COG4118D IV.B.3 essential hypothetical protein KEEP 3137225..3137270 3137225 3137270 I NA NA IG2875_Rv2830c-Rv2831 KEEP 3137271..3138020 3137271 3138020 + 249 15609968 echA16 Rv2831 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 3138021..3138098 3138021 3138021 I NA NA IG2876_Rv2831-Rv2832c KEEP 3138021..3138098 3138022 3138085 I NA NA IG2876_Rv2831-Rv2832c Only Marin et al 2022 KEEP 3138021..3138098 3138086 3138098 I NA NA IG2876_Rv2831-Rv2832c KEEP 3138099..3139181 3138099 3139181 - 360 15609969 ugpC Rv2832c COG3839G III.A.3 essential sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UGPC KEEP 3139174..3140484 3139174 3140484 - 436 15609970 ugpB Rv2833c COG1653G III.A.3 essential sn-glycerol-3-phosphate-binding lipoprotein UGPB KEEP 3140485..3140486 3140485 3140486 I NA NA IG2878_Rv2833c-Rv2834c KEEP 3140487..3141314 3140487 3141314 - 275 15609971 ugpE Rv2834c COG0395G III.A.3 nonessential sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UGPE KEEP 3141311..3142222 3141311 3142222 - 303 15609972 ugpA Rv2835c COG1175G III.A.3 nonessential sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UGPA KEEP 3142223..3142308 3142223 3142308 I NA NA IG2880_Rv2835c-Rv2836c KEEP 3142309..3143628 3142309 3143628 - 439 15609973 dinF Rv2836c COG0534V II.A.5 nonessential DNA-damage-inducible protein F KEEP 3143629..3143634 3143629 3143634 I NA NA IG2881_Rv2836c-Rv2837c KEEP 3143635..3144645 3143635 3144645 - 336 15609974 - Rv2837c COG0618R V essential hypothetical protein KEEP 3144620..3145171 3144620 3145171 - 183 15609975 rbfA Rv2838c COG0858J II.A.2 nonessential ribosome-binding factor A KEEP 3145171..3147873 3145171 3147106 - 900 15609976 infB Rv2839c COG0532J II.A.6 essential translation initiation factor IF-2 KEEP 3145171..3147873 3147107 3147108 - 900 15609976 infB Rv2839c COG0532J II.A.6 essential translation initiation factor IF-2 Only Marin et al 2022 KEEP 3145171..3147873 3147109 3147109 - 900 15609976 infB Rv2839c COG0532J II.A.6 essential translation initiation factor IF-2 KEEP 3145171..3147873 3147110 3147119 - 900 15609976 infB Rv2839c COG0532J II.A.6 essential translation initiation factor IF-2 Only Marin et al 2022 KEEP 3145171..3147873 3147120 3147873 - 900 15609976 infB Rv2839c COG0532J II.A.6 essential translation initiation factor IF-2 KEEP 3147874..3147958 3147874 3147958 I NA NA IG2884_Rv2839c-Rv2840c KEEP 3147959..3148258 3147959 3148258 - 99 15609977 - Rv2840c COG2740K V nonessential hypothetical protein KEEP 3148259..3148384 3148259 3148384 I NA NA IG2885_Rv2840c-Rv2841c KEEP 3148385..3149428 3148385 3149428 - 347 15609978 nusA Rv2841c COG0195K II.A.7 essential transcription elongation factor NusA KEEP 3149425..3149976 3149425 3149976 - 183 15609979 - Rv2842c COG0779S V nonessential hypothetical protein KEEP 3149977..3150170 3149977 3150170 I NA NA IG2887_Rv2842c-Rv2843 KEEP 3150171..3150716 3150171 3150716 + 181 15609980 - Rv2843 - II.C.5 nonessential hypothetical protein KEEP 3150713..3151201 3150713 3151201 + 162 15609981 - Rv2844 - V nonessential hypothetical protein KEEP 3151202..3152950 3151202 3152950 - 582 15609982 proS Rv2845c COG0442J II.A.3 essential prolyl-tRNA synthetase KEEP 3152951..3153038 3152951 3153038 I NA NA IG2890_Rv2845c-Rv2846c KEEP 3153039..3154631 3153039 3154631 - 530 15609983 efpA Rv2846c COG0477GEPR III.A.6 DR-inh essential integral membrane efflux protein EfpA KEEP 3154632..3154653 3154632 3154653 I NA NA IG2891_Rv2846c-Rv2847c KEEP 3154654..3155871 3154654 3155871 - 405 57117027 cysG Rv2847c COG0007H,COG1648H I.D.3 nonessential multifunctional uroporphyrinogen III methylase/precorrin-2 oxidase/ferrochelatase KEEP 3155872..3156147 3155872 3155874 I NA NA IG2892_Rv2847c-Rv2848c KEEP 3155872..3156147 3155875 3156094 I NA NA IG2892_Rv2847c-Rv2848c Only Marin et al 2022 KEEP 3155872..3156147 3156095 3156147 I NA NA IG2892_Rv2847c-Rv2848c KEEP 3156148..3157521 3156148 3157521 - 457 15609985 cobB Rv2848c COG1797H I.G.13 nonessential cobyrinic acid a,c-diamide synthase KEEP 3157521..3158144 3157521 3158144 - 207 57117028 cobO Rv2849c COG2109H I.G.13 nonessential cob(I)yrinic acid a,c-diamide adenosyltransferase KEEP 3158145..3158164 3158145 3158164 I NA NA IG2894_Rv2849c-Rv2850c KEEP 3158165..3160054 3158165 3160054 - 629 15609987 - Rv2850c COG1239H,COG1240H VI nonessential magnesium chelatase KEEP 3160051..3160521 3160051 3160521 - 156 15609988 - Rv2851c COG2153R V nonessential hypothetical protein KEEP 3160522..3160579 3160522 3160525 I NA NA IG2896_Rv2851c-Rv2852c KEEP 3160522..3160579 3160526 3160579 I NA NA IG2896_Rv2851c-Rv2852c Only Marin et al 2022 KEEP 3160580..3162061 3160580 3160587 - 493 15609989 mqo Rv2852c COG0579R I.B.7 nonessential malate:quinone oxidoreductase Only Marin et al 2022 KEEP 3160580..3162061 3160588 3162061 - 493 15609989 mqo Rv2852c COG0579R I.B.7 nonessential malate:quinone oxidoreductase KEEP 3162062..3162267 3162062 3162267 I NA NA IG2897_Rv2852c-Rv2853 KEEP 3162268..3164115 3162268 3162642 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3162268..3164115 3162643 3162703 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3162268..3164115 3162704 3162805 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3162268..3164115 3162806 3162923 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3162268..3164115 3162924 3163469 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3162268..3164115 3163470 3163548 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3162268..3164115 3163549 3163614 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3162268..3164115 3163615 3163617 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3162268..3164115 3163618 3163618 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3162268..3164115 3163619 3164033 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3162268..3164115 3164034 3164115 + 615 57117029 PE_PGRS48 Rv2853 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3164116..3164151 3164116 3164151 I NA NA IG2898_Rv2853-Rv2854 KEEP 3164152..3165192 3164152 3165192 + 346 15609991 - Rv2854 COG2267I VI nonessential hypothetical protein KEEP 3165193..3165204 3165193 3165204 I NA NA IG2899_Rv2854-Rv2855 KEEP 3165205..3166584 3165205 3166584 + 459 57117030 mtr Rv2855 COG1249C I.G.10 essential mycothione/glutathione reductase KEEP 3166585..3166683 3166585 3166683 I NA NA IG2900_Rv2855-Rv2856 KEEP 3166684..3167802 3166684 3167802 + 372 15609993 nicT Rv2856 COG3376P III.A.2 essential nickel-transport integral membrane protein KEEP 3167803..3168582 3167803 3168582 I NA NA IG2901_Rv2856-Rv2857c KEEP 3168583..3169359 3168583 3169359 - 258 15609994 - Rv2857c COG1028IQR VI essential short chain dehydrogenase KEEP 3169356..3170723 3169356 3170723 - 455 15609995 aldC Rv2858c COG1012C I.B.7 nonessential aldehyde dehydrogenase KEEP 3170720..3171646 3170720 3171458 - 308 15609996 - Rv2859c COG2071R IV.H nonessential amidotransferase KEEP 3170720..3171646 3171459 3171634 - 308 15609996 - Rv2859c COG2071R IV.H nonessential amidotransferase Only Marin et al 2022 KEEP 3170720..3171646 3171635 3171646 - 308 15609996 - Rv2859c COG2071R IV.H nonessential amidotransferase KEEP 3171627..3173000 3171627 3171634 - 457 15609997 glnA4 Rv2860c COG0174E I.D.1 nonessential glutamine synthetase Only Marin et al 2022 KEEP 3171627..3173000 3171635 3173000 - 457 15609997 glnA4 Rv2860c COG0174E I.D.1 nonessential glutamine synthetase KEEP 3173001..3173159 3173001 3173159 I NA NA IG2905_Rv2860c-Rv2861c KEEP 3173160..3174017 3173160 3174017 - 285 57117031 mapB Rv2861c COG0024J II.B.3 nonessential methionine aminopeptidase KEEP 3174018..3174058 3174018 3174058 I NA NA IG2906_Rv2861c-Rv2862c KEEP 3174059..3174643 3174059 3174643 - 194 15609999 - Rv2862c - V nonessential hypothetical protein KEEP 3174644..3174991 3174644 3174991 I NA NA IG2907_Rv2862c-Rv2863 KEEP 3174992..3175372 3174992 3175372 + 126 15610000 - Rv2863 COG1848R V nonessential hypothetical protein KEEP 3175373..3175453 3175373 3175453 I NA NA IG2908_Rv2863-Rv2864c KEEP 3175454..3177265 3175454 3177265 - 603 15610001 - Rv2864c COG0768M II.C.3 nonessential penicillin-binding lipoprotein KEEP 3177266..3177536 3177266 3177536 I NA NA IG2909_Rv2864c-Rv2865 KEEP 3177537..3177818 3177537 3177818 + 93 15610002 - Rv2865 COG2161D V nonessential hypothetical protein KEEP 3177819..3177821 3177819 3177821 I NA NA IG2910_Rv2865-Rv2866 KEEP 3177822..3178085 3177822 3178085 + 87 15610003 - Rv2866 COG2026JD V nonessential hypothetical protein KEEP 3178086..3178457 3178086 3178457 I NA NA IG2911_Rv2866-Rv2867c KEEP 3178458..3179312 3178458 3179312 - 284 15610004 - Rv2867c COG3393R V nonessential hypothetical protein KEEP 3179313..3179367 3179313 3179367 I NA NA IG2912_Rv2867c-Rv2868c KEEP 3179368..3180531 3179368 3180531 - 387 15610005 ispG Rv2868c COG0821I VII nonessential 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase KEEP 3180532..3180547 3180532 3180547 I NA NA IG2913_Rv2868c-Rv2869c KEEP 3180548..3181762 3180548 3181762 - 404 15610006 - Rv2869c COG0750M II.C.5 essential transmembrane protein KEEP 3181763..3181769 3181763 3181769 I NA NA IG2914_Rv2869c-Rv2870c KEEP 3181770..3183011 3181770 3183011 - 413 57117032 dxr Rv2870c COG0743I VII nonessential 1-deoxy-D-xylulose 5-phosphate reductoisomerase KEEP 3183012..3183137 3183012 3183137 I NA NA IG2915_Rv2870c-Rv2871 KEEP 3183138..3183395 3183138 3183395 + 85 15610008 - Rv2871 - V nonessential hypothetical protein KEEP 3183382..3183825 3183382 3183825 + 147 15610009 - Rv2872 - V nonessential hypothetical protein KEEP 3183826..3183904 3183826 3183904 I NA NA IG2917_Rv2872-Rv2873 KEEP 3183905..3184567 3183905 3184567 + 220 15610010 mpt83 Rv2873 COG2335M II.C.2 nonessential cell surface lipoprotein mpt83 (lipoprotein P23) KEEP 3184568..3184846 3184568 3184846 I NA NA IG2918_Rv2873-Rv2874 KEEP 3184847..3186934 3184847 3186934 + 695 15610011 dipZ Rv2874 COG0526OC,COG0785O IV.F nonessential integral membrane C-type cytochrome biogenesis protein DipZ KEEP 3186935..3187029 3186935 3187029 I NA NA IG2919_Rv2874-Rv2875 KEEP 3187030..3187611 3187030 3187611 + 193 15610012 mpt70 Rv2875 COG2335M II.C.2 nonessential major secreted immunogenic protein MPT70 KEEP 3187612..3187662 3187612 3187662 I NA NA IG2920_Rv2875-Rv2876 KEEP 3187663..3187977 3187663 3187977 + 104 15610013 - Rv2876 - II.C.5 nonessential transmembrane protein KEEP 3187978..3188007 3187978 3188007 I NA NA IG2921_Rv2876-Rv2877c KEEP 3188008..3188871 3188008 3188871 - 287 57117033 - Rv2877c - III.A.2 nonessential integral membrane protein KEEP 3188872..3188875 3188872 3188875 I NA NA IG2922_Rv2877c-Rv2878c KEEP 3188876..3189397 3188876 3189397 - 173 15610015 mpt53 Rv2878c COG0526OC II.C.2 nonessential soluble secreted antigen MPT53 precursor KEEP 3189398..3189582 3189398 3189478 I NA NA IG2923_Rv2878c-Rv2879c KEEP 3189398..3189582 3189479 3189582 I NA NA IG2923_Rv2878c-Rv2879c Only Marin et al 2022 KEEP 3189583..3190152 3189583 3189617 - 189 15610016 - Rv2879c COG0820R V nonessential hypothetical protein Only Marin et al 2022 KEEP 3189583..3190152 3189618 3190152 - 189 15610016 - Rv2879c COG0820R V nonessential hypothetical protein KEEP 3189851..3190678 3189851 3190678 - 275 15610017 - Rv2880c COG0820R V nonessential hypothetical protein KEEP 3190679..3190700 3190679 3190700 I NA NA IG2925_Rv2880c-Rv2881c KEEP 3190701..3191621 3190701 3191621 - 306 15610018 cdsA Rv2881c COG0575I I.H.3 essential integral membrane phosphatidate cytidylyltransferase CdsA KEEP 3191622..3191643 3191622 3191643 I NA NA IG2926_Rv2881c-Rv2882c KEEP 3191644..3192201 3191644 3192189 - 185 15610019 frr Rv2882c COG0233J II.A.6 essential ribosome recycling factor KEEP 3191644..3192201 3192190 3192201 - 185 15610019 frr Rv2882c COG0233J II.A.6 essential ribosome recycling factor Only Marin et al 2022 KEEP 3192202..3192372 3192202 3192363 I NA NA IG2927_Rv2882c-Rv2883c Only Marin et al 2022 KEEP 3192202..3192372 3192364 3192372 I NA NA IG2927_Rv2882c-Rv2883c KEEP 3192373..3193158 3192373 3193158 - 261 15610020 pyrH Rv2883c COG0528F I.F.2 essential uridylate kinase KEEP 3193159..3193392 3193159 3193392 I NA NA IG2928_Rv2883c-Rv2884 KEEP 3193393..3194151 3193393 3194135 + 252 15610021 - Rv2884 COG0745TK I.J.2 nonessential transcriptional regulatory protein KEEP 3193393..3194151 3194136 3194151 + 252 15610021 - Rv2884 COG0745TK I.J.2 nonessential transcriptional regulatory protein Only Marin et al 2022 KEEP 3194152..3194165 3194152 3194165 I NA NA IG2929_Rv2884-Rv2885c Annotation + Marin et al 2022 DISCARD 3194166..3195548 3194166 3194535 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase Annotation + Marin et al 2022 DISCARD 3194166..3195548 3194536 3194657 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase KEEP 3194166..3195548 3194658 3194763 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase Annotation + Marin et al 2022 DISCARD 3194166..3195548 3194764 3194790 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase KEEP 3194166..3195548 3194791 3194794 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase Annotation + Marin et al 2022 DISCARD 3194166..3195548 3194795 3194934 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase KEEP 3194166..3195548 3194935 3195045 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase Annotation + Marin et al 2022 DISCARD 3194166..3195548 3195046 3195057 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase KEEP 3194166..3195548 3195058 3195120 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase Annotation + Marin et al 2022 DISCARD 3194166..3195548 3195121 3195202 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase KEEP 3194166..3195548 3195203 3195283 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase Annotation + Marin et al 2022 DISCARD 3194166..3195548 3195284 3195548 - 460 15610022 - Rv2885c COG0675L IV.B.1 phage essential transposase KEEP 3195545..3196432 3195545 3196070 - 295 15610023 - Rv2886c COG2452L IV.B.1 nonessential resolvase KEEP 3195545..3196432 3196071 3196122 - 295 15610023 - Rv2886c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3195545..3196432 3196123 3196432 - 295 15610023 - Rv2886c COG2452L IV.B.1 nonessential resolvase KEEP 3196431..3196850 3196431 3196850 + 139 15610024 - Rv2887 COG1846K I.J.1 nonessential transcriptional regulatory protein KEEP 3196851..3196863 3196851 3196863 I NA NA IG2932_Rv2887-Rv2888c KEEP 3196864..3198285 3196864 3198285 - 473 15610025 amiC Rv2888c COG0154J IV.I nonessential amidase KEEP 3198286..3198291 3198286 3198291 I NA NA IG2933_Rv2888c-Rv2889c KEEP 3198292..3199107 3198292 3199107 - 271 15610026 tsf Rv2889c COG0264J II.A.6 essential elongation factor Ts KEEP 3199108..3199118 3199108 3199118 I NA NA IG2934_Rv2889c-Rv2890c KEEP 3199119..3199982 3199119 3199982 - 287 15610027 rpsB Rv2890c COG0052J II.A.1 essential 30S ribosomal protein S2 KEEP 3199983..3200265 3199983 3200265 I NA NA IG2935_Rv2890c-Rv2891 KEEP 3200266..3201015 3200266 3201015 + 249 15610028 - Rv2891 COG0739M V nonessential hypothetical protein KEEP 3200794..3202020 3200794 3201555 - 408 57117034 PPE45 Rv2892c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3200794..3202020 3201556 3201655 - 408 57117034 PPE45 Rv2892c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3200794..3202020 3201656 3202020 - 408 57117034 PPE45 Rv2892c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3202021..3202419 3202021 3202419 I NA NA IG2937_Rv2892c-Rv2893 KEEP 3202420..3203397 3202420 3203397 + 325 15610030 - Rv2893 COG2141C I.B.7 nonessential oxidoreductase KEEP 3203394..3204290 3203394 3204290 - 298 15610031 xerC Rv2894c COG0582L IV.B.3 nonessential site-specific tyrosine recombinase XerC KEEP 3204291..3204380 3204291 3204380 I NA NA IG2939_Rv2894c-Rv2895c KEEP 3204381..3205232 3204381 3205232 - 283 15610032 viuB Rv2895c COG2375P I.G.14 nonessential mycobactin utilization protein ViuB KEEP 3205233..3205264 3205233 3205264 I NA NA IG2940_Rv2895c-Rv2896c KEEP 3205265..3206434 3205265 3206434 - 389 15610033 - Rv2896c COG0758LU V nonessential hypothetical protein KEEP 3206431..3207942 3206431 3207942 - 503 15610034 - Rv2897c COG0606O V essential hypothetical protein KEEP 3207942..3208328 3207942 3208328 - 128 15610035 - Rv2898c COG0792L V nonessential hypothetical protein KEEP 3208329..3208575 3208329 3208575 I NA NA IG2943_Rv2898c-Rv2899c KEEP 3208576..3209406 3208576 3209406 - 276 15610036 fdhD Rv2899c COG1526C I.B.6b nonessential formate dehydrogenase accessory protein KEEP 3209406..3211745 3209406 3211745 - 779 15610037 fdhF Rv2900c COG0243C I.B.6b nonessential formate dehydrogenase H KEEP 3211746..3211802 3211746 3211802 I NA NA IG2945_Rv2900c-Rv2901c KEEP 3211803..3212108 3211803 3212108 - 101 15610038 - Rv2901c - V nonessential hypothetical protein KEEP 3212109..3212161 3212109 3212161 I NA NA IG2946_Rv2901c-Rv2902c KEEP 3212162..3212956 3212162 3212956 - 264 15610039 rnhB Rv2902c COG0164L II.B.1 nonessential ribonuclease HII KEEP 3212957..3212969 3212957 3212969 I NA NA IG2947_Rv2902c-Rv2903c KEEP 3212970..3213854 3212970 3213854 - 294 15610040 lepB Rv2903c COG0681U III.D essential signal peptidase I LepB KEEP 3213855..3213911 3213855 3213911 I NA NA IG2948_Rv2903c-Rv2904c KEEP 3213912..3214253 3213912 3214253 - 113 15610041 rplS Rv2904c COG0335J II.A.1 essential 50S ribosomal protein L19 KEEP 3214254..3214627 3214254 3214627 I NA NA IG2949_Rv2904c-Rv2905 KEEP 3214628..3215572 3214628 3215572 + 314 15610042 lppW Rv2905 - II.C.1 nonessential alanine rich lipoprotein LppW KEEP 3215573..3215664 3215573 3215664 I NA NA IG2950_Rv2905-Rv2906c KEEP 3215665..3216357 3215665 3216357 - 230 15610043 trmD Rv2906c COG0336J II.A.3 essential tRNA (guanine-N(1)-)-methyltransferase KEEP 3216358..3216360 3216358 3216360 I NA NA IG2951_Rv2906c-Rv2907c KEEP 3216361..3216891 3216361 3216891 - 176 15610044 rimM Rv2907c COG0806J II.A.2 essential 16S rRNA-processing protein KEEP 3216892..3216904 3216892 3216904 I NA NA IG2952_Rv2907c-Rv2908c KEEP 3216905..3217147 3216905 3217147 - 80 15610045 - Rv2908c COG1837R V essential hypothetical protein KEEP 3217148..3217154 3217148 3217154 I NA NA IG2953_Rv2908c-Rv2909c KEEP 3217155..3217643 3217155 3217643 - 162 15610046 rpsP Rv2909c COG0228J II.A.1 nonessential 30S ribosomal protein S16 KEEP 3217644..3217826 3217644 3217826 I NA NA IG2954_Rv2909c-Rv2910c KEEP 3217827..3218270 3217827 3218270 - 147 15610047 - Rv2910c - V nonessential hypothetical protein KEEP 3218271..3218338 3218271 3218338 I NA NA IG2955_Rv2910c-Rv2911 KEEP 3218339..3219214 3218339 3219214 + 291 57117035 dacB2 Rv2911 COG1686M II.C.3 nonessential D-alanyl-D-alanine carboxypeptidase KEEP 3219215..3219273 3219215 3219273 I NA NA IG2956_Rv2911-Rv2912c KEEP 3219274..3219861 3219274 3219861 - 195 15610049 - Rv2912c COG1309K I.J.1 essential TetR family transcriptional regulator KEEP 3219863..3221698 3219863 3221698 - 611 15610050 - Rv2913c COG3653Q I.A.2 nonessential D-amino acid aminohydrolase KEEP 3221699..3221766 3221699 3221766 I NA NA IG2958_Rv2913c-Rv2914c KEEP 3221767..3223524 3221767 3223524 - 585 15610051 pknI Rv2914c COG0515RTKL I.J.3 nonessential transmembrane serine/threonine-protein kinase I KEEP 3223525..3223567 3223525 3223567 I NA NA IG2959_Rv2914c-Rv2915c KEEP 3223568..3224680 3223568 3224680 - 370 15610052 - Rv2915c COG1228Q V nonessential hypothetical protein KEEP 3224681..3224707 3224681 3224707 I NA NA IG2960_Rv2915c-Rv2916c KEEP 3224708..3226285 3224708 3226285 - 525 15610053 ffh Rv2916c COG0541U III.D essential signal recognition particle protein KEEP 3226286..3226362 3226286 3226324 I NA NA IG2961_Rv2916c-Rv2917 KEEP 3226286..3226362 3226325 3226362 I NA NA IG2961_Rv2916c-Rv2917 Only Marin et al 2022 KEEP 3226363..3228243 3226363 3226402 + 626 15610054 - Rv2917 COG1061KL V nonessential hypothetical protein Only Marin et al 2022 KEEP 3226363..3228243 3226403 3228243 + 626 15610054 - Rv2917 COG1061KL V nonessential hypothetical protein KEEP 3228244..3228253 3228244 3228253 I NA NA IG2962_Rv2917-Rv2918c KEEP 3228254..3230680 3228254 3230680 - 808 15610055 glnD Rv2918c COG2844O I.D.1 nonessential PII uridylyl-transferase KEEP 3230681..3230737 3230681 3230737 I NA NA IG2963_Rv2918c-Rv2919c KEEP 3230738..3231076 3230738 3231076 - 112 15610056 glnB Rv2919c COG0347E I.J.1 nonessential nitrogen regulatory protein P-II GLNB KEEP 3231073..3232506 3231073 3232506 - 477 15610057 amt Rv2920c COG0004P III.A.2 nonessential ammonium transporter KEEP 3232507..3232870 3232507 3232870 I NA NA IG2965_Rv2920c-Rv2921c Only Marin et al 2022 KEEP 3232871..3234139 3232871 3234139 - 422 15610058 ftsY Rv2921c COG0552U III.C essential cell division protein FtsY KEEP 3234140..3234188 3234140 3234188 I NA NA IG2966_Rv2921c-Rv2922c KEEP 3234189..3237806 3234189 3237806 - 1205 57117036 smc Rv2922c COG1196D IV.I nonessential chromosome partition protein Smc KEEP 3237807..3237817 3237807 3237817 I NA NA IG2967_Rv2922c-Rv2922A KEEP 3237818..3238099 3237818 3238099 - 93 57117037 acyP Rv2922A COG1254C III.C nonessential acylphosphatase KEEP 3238086..3238499 3238086 3238499 - 137 15610060 - Rv2923c COG1765O V nonessential hypothetical protein KEEP 3238500..3238600 3238500 3238600 I NA NA IG2969_Rv2923c-Rv2924c KEEP 3238601..3239470 3238601 3239465 - 289 15610061 fpg Rv2924c COG0266L II.A.5 nonessential formamidopyrimidine-DNA glycosylase KEEP 3238601..3239470 3239466 3239470 - 289 15610061 fpg Rv2924c COG0266L II.A.5 nonessential formamidopyrimidine-DNA glycosylase Only Marin et al 2022 KEEP 3239471..3239828 3239471 3239794 I NA NA IG2970_Rv2924c-Rv2925c Only Marin et al 2022 KEEP 3239471..3239828 3239795 3239828 I NA NA IG2970_Rv2924c-Rv2925c KEEP 3239829..3240551 3239829 3240551 - 240 15610062 rnc Rv2925c COG0571K II.B.1 essential ribonuclease III KEEP 3240548..3241171 3240548 3241171 - 207 15610063 - Rv2926c COG1399R V essential hypothetical protein KEEP 3241172..3241221 3241172 3241221 I NA NA IG2972_Rv2926c-Rv2927c KEEP 3241222..3241959 3241222 3241959 - 245 15610064 - Rv2927c COG3599D V essential hypothetical protein KEEP 3241960..3242197 3241960 3242197 I NA NA IG2973_Rv2927c-Rv2928 KEEP 3242198..3242983 3242198 3242983 + 261 15610065 tesA Rv2928 COG3208Q I.I nonessential thioesterase TESA KEEP 3242970..3243281 3242970 3243281 + 103 15610066 - Rv2929 - VI nonessential hypothetical protein KEEP 3243282..3243696 3243282 3243696 I NA NA IG2975_Rv2929-Rv2930 KEEP 3243697..3245448 3243697 3245097 + 583 57117038 fadD26 Rv2930 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 3243697..3245448 3245098 3245166 + 583 57117038 fadD26 Rv2930 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 3243697..3245448 3245167 3245320 + 583 57117038 fadD26 Rv2930 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 3243697..3245448 3245321 3245389 + 583 57117038 fadD26 Rv2930 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 3243697..3245448 3245390 3245448 + 583 57117038 fadD26 Rv2930 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 3245445..3251075 3245445 3247232 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA KEEP 3245445..3251075 3247233 3247304 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA Only Marin et al 2022 KEEP 3245445..3251075 3247305 3247312 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA KEEP 3245445..3251075 3247313 3247471 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA Only Marin et al 2022 KEEP 3245445..3251075 3247472 3247556 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA KEEP 3245445..3251075 3247557 3247739 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA Only Marin et al 2022 KEEP 3245445..3251075 3247740 3247808 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA KEEP 3245445..3251075 3247809 3248173 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA Only Marin et al 2022 KEEP 3245445..3251075 3248174 3248282 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA KEEP 3245445..3251075 3248283 3248335 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA Only Marin et al 2022 KEEP 3245445..3251075 3248336 3251075 + 1876 15610068 ppsA Rv2931 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSA KEEP 3251072..3255688 3251072 3251410 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB KEEP 3251072..3255688 3251411 3251470 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB Only Marin et al 2022 KEEP 3251072..3255688 3251471 3252646 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB KEEP 3251072..3255688 3252647 3252718 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB Marin et al 2022 + homoplasy analysis DISCARD 3251072..3255688 3252719 3252726 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB KEEP 3251072..3255688 3252727 3252885 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB Only Marin et al 2022 KEEP 3251072..3255688 3252886 3252970 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB KEEP 3251072..3255688 3252971 3253153 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB Marin et al 2022 + homoplasy analysis DISCARD 3251072..3255688 3253154 3253222 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB KEEP 3251072..3255688 3253223 3253587 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB Only Marin et al 2022 KEEP 3251072..3255688 3253588 3253732 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB KEEP 3251072..3255688 3253733 3253738 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB Only Marin et al 2022 KEEP 3251072..3255688 3253739 3255688 + 1538 15610069 ppsB Rv2932 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSB KEEP 3255685..3262251 3255685 3257961 + 2188 15610070 ppsC Rv2933 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSC KEEP 3255685..3262251 3257962 3258024 + 2188 15610070 ppsC Rv2933 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSC Only Marin et al 2022 KEEP 3255685..3262251 3258025 3258180 + 2188 15610070 ppsC Rv2933 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSC KEEP 3255685..3262251 3258181 3258232 + 2188 15610070 ppsC Rv2933 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSC Only Marin et al 2022 KEEP 3255685..3262251 3258233 3258341 + 2188 15610070 ppsC Rv2933 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSC KEEP 3255685..3262251 3258342 3258404 + 2188 15610070 ppsC Rv2933 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSC Only Marin et al 2022 KEEP 3255685..3262251 3258405 3262251 + 2188 15610070 ppsC Rv2933 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSC KEEP 3262248..3267731 3262248 3262592 + 1827 15610071 ppsD Rv2934 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSD KEEP 3262248..3267731 3262593 3262652 + 1827 15610071 ppsD Rv2934 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSD Only Marin et al 2022 KEEP 3262248..3267731 3262653 3266034 + 1827 15610071 ppsD Rv2934 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSD KEEP 3262248..3267731 3266035 3266081 + 1827 15610071 ppsD Rv2934 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSD Only Marin et al 2022 KEEP 3262248..3267731 3266082 3267731 + 1827 15610071 ppsD Rv2934 COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSD KEEP 3267732..3267736 3267732 3267736 I NA NA IG2980_Rv2934-Rv2935 KEEP 3267737..3272203 3267737 3272203 + 1488 15610072 ppsE Rv2935 COG1020Q,COG3321Q I.I nonessential phenolpthiocerol synthesis type-I polyketide synthase PPSE KEEP 3272204..3272213 3272204 3272213 I NA NA IG2981_Rv2935-Rv2936 KEEP 3272214..3273209 3272214 3273209 + 331 15610073 drrA Rv2936 COG1131V III.A.6 essential daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA KEEP 3273206..3274075 3273206 3274075 + 289 15610074 drrB Rv2937 COG0842V III.A.6 essential daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB KEEP 3274072..3274902 3274072 3274902 + 276 15610075 drrC Rv2938 COG0842V III.A.6 essential daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC KEEP 3274903..3274948 3274903 3274948 I NA NA IG2984_Rv2938-Rv2939 KEEP 3274949..3276217 3274949 3276217 + 422 15610076 papA5 Rv2939 COG1020Q I.I nonessential acyltransferase PapA5 KEEP 3276218..3276379 3276218 3276379 I NA NA IG2985_Rv2939-Rv2940c KEEP 3276380..3282715 3276380 3276955 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS KEEP 3276380..3282715 3276956 3277006 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS Only Marin et al 2022 KEEP 3276380..3282715 3277007 3277820 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS KEEP 3276380..3282715 3277821 3277904 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS Only Marin et al 2022 KEEP 3276380..3282715 3277905 3281069 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS KEEP 3276380..3282715 3281070 3281123 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS Only Marin et al 2022 KEEP 3276380..3282715 3281124 3281220 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS KEEP 3276380..3282715 3281221 3281240 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS Only Marin et al 2022 KEEP 3276380..3282715 3281241 3282715 - 2111 15610077 mas Rv2940c COG3321Q I.I nonessential multifunctional mycocerosic acid synthase membrane-associated MAS KEEP 3282716..3283334 3282716 3283334 I NA NA IG2986_Rv2940c-Rv2941 KEEP 3283335..3285077 3283335 3284729 + 580 15610078 fadD28 Rv2941 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 3283335..3285077 3284730 3284810 + 580 15610078 fadD28 Rv2941 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 3283335..3285077 3284811 3285077 + 580 15610078 fadD28 Rv2941 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 3285070..3287832 3285070 3287832 + 920 15610079 mmpL7 Rv2942 COG2409R II.C.4 essential transmembrane transport protein MmpL7 KEEP 3287833..3288463 3287833 3287949 I NA NA IG2988_Rv2942-Rv2943 KEEP 3287833..3288463 3287950 3288005 I NA NA IG2988_Rv2942-Rv2943 Annotation + Marin et al 2022 DISCARD 3287833..3288463 3288006 3288463 I NA NA IG2988_Rv2942-Rv2943 KEEP 3288464..3289705 3288464 3289705 + 413 15610080 - Rv2943 COG4584L IV.B.1 phage nonessential IS1533 transposase KEEP 3289705..3290235 3289705 3290235 + 176 57117039 - Rv2943A COG1484L IV.B.1 phage nonessential transposase KEEP 3289790..3290506 3289790 3290431 + 238 15610081 - Rv2944 COG1484L IV.B.1 phage nonessential IS1533 transposase KEEP 3289790..3290506 3290432 3290482 + 238 15610081 - Rv2944 COG1484L IV.B.1 phage nonessential IS1533 transposase Annotation + Marin et al 2022 DISCARD 3289790..3290506 3290483 3290506 + 238 15610081 - Rv2944 COG1484L IV.B.1 phage nonessential IS1533 transposase KEEP 3290507..3290623 3290507 3290623 I NA NA IG2991_Rv2944-Rv2945c KEEP 3290624..3291325 3290624 3291325 - 233 15610082 lppX Rv2945c - II.C.1 essential lipoprotein LppX KEEP 3291326..3291502 3291326 3291392 I NA NA IG2992_Rv2945c-Rv2946c KEEP 3291326..3291502 3291393 3291502 I NA NA IG2992_Rv2945c-Rv2946c Only Marin et al 2022 KEEP 3291503..3296353 3291503 3291510 - 1616 15610083 pks1 Rv2946c COG3321Q I.I nonessential polyketide synthase PKS1 Only Marin et al 2022 KEEP 3291503..3296353 3291511 3292982 - 1616 15610083 pks1 Rv2946c COG3321Q I.I nonessential polyketide synthase PKS1 KEEP 3291503..3296353 3292983 3293052 - 1616 15610083 pks1 Rv2946c COG3321Q I.I nonessential polyketide synthase PKS1 Only Marin et al 2022 KEEP 3291503..3296353 3293053 3293177 - 1616 15610083 pks1 Rv2946c COG3321Q I.I nonessential polyketide synthase PKS1 KEEP 3291503..3296353 3293178 3293237 - 1616 15610083 pks1 Rv2946c COG3321Q I.I nonessential polyketide synthase PKS1 Only Marin et al 2022 KEEP 3291503..3296353 3293238 3295506 - 1616 15610083 pks1 Rv2946c COG3321Q I.I nonessential polyketide synthase PKS1 KEEP 3291503..3296353 3295507 3295562 - 1616 15610083 pks1 Rv2946c COG3321Q I.I nonessential polyketide synthase PKS1 Only Marin et al 2022 KEEP 3291503..3296353 3295563 3296353 - 1616 15610083 pks1 Rv2946c COG3321Q I.I nonessential polyketide synthase PKS1 KEEP 3296350..3297840 3296350 3296593 - 496 15610084 pks15 Rv2947c COG3321Q I.I nonessential polyketide synthase PKS15 KEEP 3296350..3297840 3296594 3296665 - 496 15610084 pks15 Rv2947c COG3321Q I.I nonessential polyketide synthase PKS15 Only Marin et al 2022 KEEP 3296350..3297840 3296666 3297172 - 496 15610084 pks15 Rv2947c COG3321Q I.I nonessential polyketide synthase PKS15 KEEP 3296350..3297840 3297173 3297238 - 496 15610084 pks15 Rv2947c COG3321Q I.I nonessential polyketide synthase PKS15 Only Marin et al 2022 KEEP 3296350..3297840 3297239 3297840 - 496 15610084 pks15 Rv2947c COG3321Q I.I nonessential polyketide synthase PKS15 KEEP 3297837..3299954 3297837 3299954 - 705 15610085 fadD22 Rv2948c COG0318IQ,COG1020Q I.A.3 nonessential acyl-CoA synthetase KEEP 3299955..3299970 3299955 3299970 I NA NA IG2995_Rv2948c-Rv2949c KEEP 3299971..3300570 3299971 3300570 - 199 15610086 - Rv2949c COG3161H V nonessential hypothetical protein KEEP 3300571..3300595 3300571 3300595 I NA NA IG2996_Rv2949c-Rv2950c KEEP 3300596..3302344 3300596 3302344 - 582 161352463 fadD29 Rv2950c COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 3302345..3303102 3302345 3303102 I NA NA IG2997_Rv2950c-Rv2951c KEEP 3303103..3304248 3303103 3304248 - 381 15610088 - Rv2951c COG2141C I.B.7 nonessential oxidoreductase KEEP 3304249..3304440 3304249 3304440 I NA NA IG2998_Rv2951c-Rv2952 KEEP 3304441..3305253 3304441 3305253 + 270 15610089 - Rv2952 COG0500QR IV.H nonessential methyltransferase (methylase) KEEP 3305254..3305278 3305254 3305278 I NA NA IG2999_Rv2952-Rv2953 KEEP 3305279..3306535 3305279 3306535 + 418 15610090 - Rv2953 COG3268S V nonessential hypothetical protein KEEP 3306536..3306665 3306536 3306665 I NA NA IG3000_Rv2953-Rv2954c KEEP 3306666..3307391 3306666 3307391 - 241 15610091 - Rv2954c COG0500QR VI nonessential hypothetical protein KEEP 3307392..3307579 3307392 3307579 I NA NA IG3001_Rv2954c-Rv2955c KEEP 3307580..3308545 3307580 3307726 - 321 15610092 - Rv2955c COG0500QR V nonessential hypothetical protein KEEP 3307580..3308545 3307727 3307761 - 321 15610092 - Rv2955c COG0500QR V nonessential hypothetical protein Only Marin et al 2022 KEEP 3307580..3308545 3307762 3308545 - 321 15610092 - Rv2955c COG0500QR V nonessential hypothetical protein KEEP 3308546..3308667 3308546 3308667 I NA NA IG3002_Rv2955c-Rv2956 KEEP 3308668..3309399 3308668 3309399 + 243 15610093 - Rv2956 COG0500QR V nonessential hypothetical protein KEEP 3309400..3309469 3309400 3309469 I NA NA IG3003_Rv2956-Rv2957 KEEP 3309470..3310297 3309470 3310297 + 275 15610094 - Rv2957 COG0463M IV.H nonessential glycosyl transferase KEEP 3310298..3310713 3310298 3310713 I NA NA IG3004_Rv2957-Rv2958c KEEP 3310714..3312000 3310714 3311026 - 428 15610095 - Rv2958c COG1819GC IV.H nonessential glycosyl transferase KEEP 3310714..3312000 3311027 3311090 - 428 15610095 - Rv2958c COG1819GC IV.H nonessential glycosyl transferase Only Marin et al 2022 KEEP 3310714..3312000 3311091 3311307 - 428 15610095 - Rv2958c COG1819GC IV.H nonessential glycosyl transferase KEEP 3310714..3312000 3311308 3311393 - 428 15610095 - Rv2958c COG1819GC IV.H nonessential glycosyl transferase Only Marin et al 2022 KEEP 3310714..3312000 3311394 3311533 - 428 15610095 - Rv2958c COG1819GC IV.H nonessential glycosyl transferase KEEP 3310714..3312000 3311534 3311599 - 428 15610095 - Rv2958c COG1819GC IV.H nonessential glycosyl transferase Only Marin et al 2022 KEEP 3310714..3312000 3311600 3312000 - 428 15610095 - Rv2958c COG1819GC IV.H nonessential glycosyl transferase KEEP 3312001..3312100 3312001 3312100 I NA NA IG3005_Rv2958c-Rv2959c KEEP 3312101..3312838 3312101 3312838 - 245 15610096 - Rv2959c COG3510V IV.H nonessential methyltransferase (methylase) KEEP 3312839..3312952 3312839 3312952 I NA NA IG3006_Rv2959c-Rv2960c KEEP 3312953..3313201 3312953 3313201 - 82 15610097 - Rv2960c - VI nonessential hypothetical protein KEEP 3313202..3313282 3313202 3313282 I NA NA IG3007_Rv2960c-Rv2961 KEEP 3313283..3313672 3313283 3313345 + 129 15610098 - Rv2961 COG3039L IV.B.1 phage nonessential transposase KEEP 3313283..3313672 3313346 3313396 + 129 15610098 - Rv2961 COG3039L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3313283..3313672 3313397 3313672 + 129 15610098 - Rv2961 COG3039L IV.B.1 phage nonessential transposase KEEP 3313673..3313772 3313673 3313772 I NA NA IG3008_Rv2961-Rv2962c KEEP 3313773..3315122 3313773 3314115 - 449 15610099 - Rv2962c COG1819GC IV.H nonessential glycosyl transferase KEEP 3313773..3315122 3314116 3314179 - 449 15610099 - Rv2962c COG1819GC IV.H nonessential glycosyl transferase Only Marin et al 2022 KEEP 3313773..3315122 3314180 3314396 - 449 15610099 - Rv2962c COG1819GC IV.H nonessential glycosyl transferase KEEP 3313773..3315122 3314397 3314482 - 449 15610099 - Rv2962c COG1819GC IV.H nonessential glycosyl transferase Only Marin et al 2022 KEEP 3313773..3315122 3314483 3314622 - 449 15610099 - Rv2962c COG1819GC IV.H nonessential glycosyl transferase KEEP 3313773..3315122 3314623 3314688 - 449 15610099 - Rv2962c COG1819GC IV.H nonessential glycosyl transferase Only Marin et al 2022 KEEP 3313773..3315122 3314689 3315122 - 449 15610099 - Rv2962c COG1819GC IV.H nonessential glycosyl transferase KEEP 3315123..3315235 3315123 3315235 I NA NA IG3009_Rv2962c-Rv2963 KEEP 3315236..3316456 3315236 3316456 + 406 15610100 - Rv2963 COG0701R II.C.5 nonessential integral membrane protein KEEP 3316457..3316528 3316457 3316528 I NA NA IG3010_Rv2963-Rv2964 KEEP 3316529..3317461 3316529 3317461 + 310 15610101 purU Rv2964 COG0788F I.F.1 nonessential formyltetrahydrofolate deformylase KEEP 3317462..3318329 3317462 3317571 I NA NA IG3011_Rv2964-Rv2965c KEEP 3317462..3318329 3317572 3317743 I NA NA IG3011_Rv2964-Rv2965c Only Marin et al 2022 KEEP 3317462..3318329 3317744 3318329 I NA NA IG3011_Rv2964-Rv2965c KEEP 3318330..3318815 3318330 3318815 - 161 15610102 coaD Rv2965c COG0669H II.C.2 nonessential phosphopantetheine adenylyltransferase KEEP 3318816..3318900 3318816 3318900 I NA NA IG3012_Rv2965c-Rv2966c KEEP 3318901..3319467 3318901 3319467 - 188 15610103 - Rv2966c COG0742L IV.H nonessential methyltransferase (methylase) KEEP 3319468..3319662 3319468 3319662 I NA NA IG3013_Rv2966c-Rv2967c Only Marin et al 2022 KEEP 3319663..3323046 3319663 3319665 - 1127 15610104 pca Rv2967c COG1038C I.B.3 essential pyruvate carboxylase Only Marin et al 2022 KEEP 3319663..3323046 3319666 3323046 - 1127 15610104 pca Rv2967c COG1038C I.B.3 essential pyruvate carboxylase KEEP 3323047..3323070 3323047 3323070 I NA NA IG3014_Rv2967c-Rv2968c KEEP 3323071..3323703 3323071 3323703 - 210 15610105 - Rv2968c COG4243S II.C.5 essential integral membrane protein KEEP 3323704..3323708 3323704 3323708 I NA NA IG3015_Rv2968c-Rv2969c KEEP 3323709..3324476 3323709 3324476 - 255 15610106 - Rv2969c COG1651O II.C.5 essential hypothetical protein KEEP 3324477..3324572 3324477 3324572 I NA NA IG3016_Rv2969c-Rv2970c KEEP 3324573..3325703 3324573 3325703 - 376 15610107 lipN Rv2970c COG0657I V nonessential lipase/esterase LipN KEEP 3325704..3325933 3325704 3325933 I NA NA IG3017_Rv2970c-Rv2970A KEEP 3325934..3326104 3325934 3326104 + 56 57117040 - Rv2970A COG0656R II.B.5 nonessential hypothetical protein KEEP 3326101..3326949 3326101 3326949 + 282 15610108 - Rv2971 COG0656R I.B.7 essential oxidoreductase KEEP 3326950..3327022 3326950 3327022 I NA NA IG3019_Rv2971-Rv2972c KEEP 3327023..3327736 3327023 3327736 - 237 15610109 - Rv2972c - II.C.5 nonessential hypothetical protein KEEP 3327733..3329946 3327733 3329946 - 737 15610110 recG Rv2973c COG1200LK II.A.5 nonessential ATP-dependent DNA helicase RECG KEEP 3329947..3329948 3329947 3329948 I NA NA IG3021_Rv2973c-Rv2974c KEEP 3329949..3331361 3329949 3331361 - 470 15610111 - Rv2974c COG1461R V nonessential hypothetical protein KEEP 3331358..3331612 3331358 3331612 - 84 15610112 - Rv2975c COG1461R V nonessential hypothetical protein KEEP 3331613..3332070 3331613 3332070 I NA NA IG3023_Rv2975c-Rv2976c KEEP 3332071..3332754 3332071 3332754 - 227 15610113 ung Rv2976c COG0692L II.A.5 essential uracil-DNA glycosylase KEEP 3332755..3332786 3332755 3332786 I NA NA IG3024_Rv2976c-Rv2977c KEEP 3332787..3333788 3332787 3333752 - 333 15610114 thiL Rv2977c COG0611H I.G.8 essential thiamine monophosphate kinase KEEP 3332787..3333788 3333753 3333788 - 333 15610114 thiL Rv2977c COG0611H I.G.8 essential thiamine monophosphate kinase Only Marin et al 2022 KEEP 3333785..3335164 3333785 3333984 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3333785..3335164 3333985 3333989 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase KEEP 3333785..3335164 3333990 3334184 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3333785..3335164 3334185 3334238 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase KEEP 3333785..3335164 3334239 3334370 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3333785..3335164 3334371 3334556 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase KEEP 3333785..3335164 3334557 3334609 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3333785..3335164 3334610 3334645 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase KEEP 3333785..3335164 3334646 3334739 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3333785..3335164 3334740 3334821 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase KEEP 3333785..3335164 3334822 3334960 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3333785..3335164 3334961 3335015 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase KEEP 3333785..3335164 3335016 3335084 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3333785..3335164 3335085 3335164 - 459 15610115 - Rv2978c COG0675L IV.B.1 phage nonessential transposase KEEP 3335164..3335748 3335164 3335245 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase KEEP 3335164..3335748 3335246 3335317 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3335164..3335748 3335318 3335356 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase KEEP 3335164..3335748 3335357 3335410 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3335164..3335748 3335411 3335446 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase KEEP 3335164..3335748 3335447 3335497 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3335164..3335748 3335498 3335503 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase KEEP 3335164..3335748 3335504 3335566 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3335164..3335748 3335567 3335740 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase KEEP 3335164..3335748 3335741 3335748 - 194 15610116 - Rv2979c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 3335749..3335959 3335749 3335815 I NA NA IG3027_Rv2979c-Rv2980 Only Marin et al 2022 KEEP 3335749..3335959 3335816 3335959 I NA NA IG3027_Rv2979c-Rv2980 KEEP 3335960..3336505 3335960 3336499 + 181 15610117 - Rv2980 - VI nonessential hypothetical protein KEEP 3335960..3336505 3336500 3336505 + 181 15610117 - Rv2980 - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 3336506..3336795 3336506 3336795 I NA NA IG3028_Rv2980-Rv2981c Marin et al 2022 + homoplasy analysis DISCARD 3336796..3337917 3336796 3336803 - 373 15610118 ddl Rv2981c COG1181M II.C.3 essential D-alanyl-alanine synthetase A Only Marin et al 2022 KEEP 3336796..3337917 3336804 3337917 - 373 15610118 ddl Rv2981c COG1181M II.C.3 essential D-alanyl-alanine synthetase A KEEP 3337918..3337994 3337918 3337994 I NA NA IG3029_Rv2981c-Rv2982c KEEP 3337995..3338999 3337995 3338999 - 334 15610119 gpsA Rv2982c COG0240C I.H.3 nonessential NAD(P)H-dependent glycerol-3-phosphate dehydrogenase KEEP 3339000..3339117 3339000 3339117 I NA NA IG3030_Rv2982c-Rv2983 KEEP 3339118..3339762 3339118 3339762 + 214 15610120 - Rv2983 COG1920S V nonessential hypothetical protein KEEP 3339763..3339853 3339763 3339853 I NA NA IG3031_Rv2983-Rv2984 KEEP 3339854..3342082 3339854 3342082 + 742 15610121 ppk Rv2984 COG0855P I.A.4 nonessential polyphosphate kinase KEEP 3342083..3342164 3342083 3342164 I NA NA IG3032_Rv2984-Rv2985 KEEP 3342165..3343118 3342165 3343118 + 317 15610122 mutT1 Rv2985 COG0406G,COG0494LR II.A.5 nonessential hydrolase MutT1 KEEP 3343119..3343175 3343119 3343175 I NA NA IG3033_Rv2985-Rv2986c KEEP 3343176..3343820 3343176 3343347 - 214 15610123 hupB Rv2986c COG0776L II.A.4 essential DNA-binding protein HU KEEP 3343176..3343820 3343348 3343447 - 214 15610123 hupB Rv2986c COG0776L II.A.4 essential DNA-binding protein HU Only Marin et al 2022 KEEP 3343176..3343820 3343448 3343820 - 214 15610123 hupB Rv2986c COG0776L II.A.4 essential DNA-binding protein HU KEEP 3343821..3344032 3343821 3344032 I NA NA IG3034_Rv2986c-Rv2987c KEEP 3344033..3344629 3344033 3344629 - 198 15610124 leuD Rv2987c COG0066E I.D.7 essential isopropylmalate isomerase small subunit KEEP 3344630..3344653 3344630 3344653 I NA NA IG3035_Rv2987c-Rv2988c KEEP 3344654..3346075 3344654 3346075 - 473 15610125 leuC Rv2988c COG0065E I.D.7 nonessential isopropylmalate isomerase large subunit KEEP 3346076..3346146 3346076 3346146 I NA NA IG3036_Rv2988c-Rv2989 KEEP 3346147..3346848 3346147 3346848 + 233 15610126 - Rv2989 COG1414K I.J.1 nonessential transcriptional regulatory protein KEEP 3346849..3346858 3346849 3346858 I NA NA IG3037_Rv2989-Rv2990c KEEP 3346859..3347719 3346859 3347719 - 286 15610127 - Rv2990c - VI nonessential hypothetical protein KEEP 3347720..3347981 3347720 3347981 I NA NA IG3038_Rv2990c-Rv2991 KEEP 3347982..3348473 3347982 3348473 + 163 15610128 - Rv2991 COG0748P V nonessential hypothetical protein KEEP 3348474..3348804 3348474 3348476 I NA NA IG3039_Rv2991-Rv2992c KEEP 3348474..3348804 3348477 3348544 I NA NA IG3039_Rv2991-Rv2992c Only Marin et al 2022 KEEP 3348474..3348804 3348545 3348804 I NA NA IG3039_Rv2991-Rv2992c KEEP 3348805..3350277 3348805 3350277 - 490 57117041 gltX Rv2992c COG0008J II.A.3 essential glutamyl-tRNA synthetase KEEP 3350274..3350993 3350274 3350993 - 239 15610130 - Rv2993c COG0179Q VII nonessential 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase KEEP 3350994..3351268 3350994 3351083 I NA NA IG3041_Rv2993c-Rv2994 KEEP 3350994..3351268 3351084 3351220 I NA NA IG3041_Rv2993c-Rv2994 Only Marin et al 2022 KEEP 3350994..3351268 3351221 3351268 I NA NA IG3041_Rv2993c-Rv2994 KEEP 3351269..3352606 3351269 3352606 + 445 15610131 - Rv2994 COG0477GEPR III.A.6 nonessential integral membrane protein KEEP 3352458..3353468 3352458 3353468 - 336 15610132 leuB Rv2995c COG0473CE I.D.7 essential 3-isopropylmalate dehydrogenase KEEP 3353469..3353482 3353469 3353482 I NA NA IG3043_Rv2995c-Rv2996c KEEP 3353483..3355069 3353483 3355069 - 528 57117042 serA1 Rv2996c COG0111HE I.D.3 essential D-3-phosphoglycerate dehydrogenase KEEP 3355070..3355098 3355070 3355098 I NA NA IG3044_Rv2996c-Rv2997 KEEP 3355099..3356541 3355099 3356541 + 480 15610134 - Rv2997 COG1233Q VI nonessential alanine rich dehydrogenase KEEP 3356542..3356814 3356542 3356814 I NA NA IG3045_Rv2997-Rv2998 KEEP 3356815..3357276 3356815 3357276 + 153 15610135 - Rv2998 - VI essential hypothetical protein KEEP 3357225..3357428 3357225 3357428 - 67 57117043 - Rv2998A COG0642T V nonessential hypothetical protein KEEP 3357429..3357601 3357429 3357601 I NA NA IG3047_Rv2998A-Rv2999 KEEP 3357602..3358567 3357602 3358567 + 321 15610136 lppY Rv2999 - II.C.1 essential lipoprotein LppY KEEP 3358568..3358611 3358568 3358611 I NA NA IG3048_Rv2999-Rv3000 KEEP 3358612..3359271 3358612 3359271 + 219 15610137 - Rv3000 COG0390R,COG1132V II.C.5 nonessential transmembrane protein KEEP 3359272..3359584 3359272 3359584 I NA NA IG3049_Rv3000-Rv3001c KEEP 3359585..3360586 3359585 3360586 - 333 15610138 ilvC Rv3001c COG0059EH I.D.7 essential ketol-acid reductoisomerase KEEP 3360587..3360623 3360587 3360623 I NA NA IG3050_Rv3001c-Rv3002c KEEP 3360624..3361130 3360624 3361130 - 168 15610139 ilvH Rv3002c COG0440E I.D.7 essential acetolactate synthase 3 regulatory subunit KEEP 3361130..3362986 3361130 3362986 - 618 57117044 ilvB1 Rv3003c COG0028EH I.D.7 essential acetolactate synthase 1 catalytic subunit KEEP 3362987..3363347 3362987 3363347 I NA NA IG3052_Rv3003c-Rv3004 KEEP 3363348..3363686 3363348 3363686 + 112 15610141 cfp6 Rv3004 COG2177D VI nonessential low molecular weight protein antigen 6 (CFP-6) KEEP 3363687..3363692 3363687 3363692 I NA NA IG3053_Rv3004-Rv3005c KEEP 3363693..3364532 3363693 3364532 - 279 15610142 - Rv3005c COG2259S V nonessential hypothetical protein KEEP 3364533..3364708 3364533 3364708 I NA NA IG3054_Rv3005c-Rv3006 KEEP 3364709..3365830 3364709 3365830 + 373 15610143 lppZ Rv3006 COG2133G II.C.1 nonessential lipoprotein LppZ KEEP 3365831..3365835 3365831 3365835 I NA NA IG3055_Rv3006-Rv3007c KEEP 3365836..3366450 3365836 3366450 - 204 15610144 - Rv3007c COG1853R I.B.7 nonessential oxidoreductase KEEP 3366451..3366643 3366451 3366643 I NA NA IG3056_Rv3007c-Rv3008 KEEP 3366644..3367267 3366644 3367267 + 207 15610145 - Rv3008 COG1285S VI nonessential hypothetical protein KEEP 3367264..3368793 3367264 3368793 - 509 15610146 gatB Rv3009c COG0064J II.A.3 essential aspartyl/glutamyl-tRNA amidotransferase subunit B KEEP 3368794..3368822 3368794 3368822 I NA NA IG3058_Rv3009c-Rv3010c KEEP 3368823..3369854 3368823 3369854 - 343 15610147 pfkA Rv3010c COG0205G I.B.1 nonessential 6-phosphofructokinase KEEP 3369855..3369949 3369855 3369929 I NA NA IG3059_Rv3010c-Rv3011c KEEP 3369855..3369949 3369930 3369931 I NA NA IG3059_Rv3010c-Rv3011c Only Marin et al 2022 KEEP 3369855..3369949 3369932 3369936 I NA NA IG3059_Rv3010c-Rv3011c KEEP 3369855..3369949 3369937 3369942 I NA NA IG3059_Rv3010c-Rv3011c Only Marin et al 2022 KEEP 3369855..3369949 3369943 3369949 I NA NA IG3059_Rv3010c-Rv3011c KEEP 3369950..3371434 3369950 3371434 - 494 15610148 gatA Rv3011c COG0154J II.A.3 essential aspartyl/glutamyl-tRNA amidotransferase subunit A KEEP 3371431..3371730 3371431 3371730 - 99 15610149 gatC Rv3012c COG0721J II.A.3 nonessential aspartyl/glutamyl-tRNA amidotransferase subunit C KEEP 3371731..3371814 3371731 3371814 I NA NA IG3061_Rv3012c-Rv3013 KEEP 3371815..3372471 3371815 3372471 + 218 15610150 - Rv3013 COG1171E V nonessential hypothetical protein KEEP 3372472..3372544 3372472 3372544 I NA NA IG3062_Rv3013-Rv3014c KEEP 3372545..3374620 3372545 3374620 - 691 15610151 ligA Rv3014c COG0272L II.A.5 essential NAD-dependent DNA ligase LigA KEEP 3374621..3374650 3374621 3374650 I NA NA IG3063_Rv3014c-Rv3015c KEEP 3374651..3375664 3374651 3375664 - 337 15610152 - Rv3015c - V nonessential hypothetical protein KEEP 3375665..3375757 3375665 3375757 I NA NA IG3064_Rv3015c-Rv3016 KEEP 3375758..3376387 3375758 3376387 + 209 15610153 lpqA Rv3016 - II.C.1 nonessential lipoprotein LpqA KEEP 3376388..3376489 3376388 3376489 I NA NA IG3065_Rv3016-Rv3017c KEEP 3376490..3376852 3376490 3376514 - 120 15610154 esxQ Rv3017c - VI nonessential Esat-6 like protein esxQ (TB12.9) (Esat-6 like protein 8) KEEP 3376490..3376852 3376515 3376543 - 120 15610154 esxQ Rv3017c - VI nonessential Esat-6 like protein esxQ (TB12.9) (Esat-6 like protein 8) Only Marin et al 2022 KEEP 3376490..3376852 3376544 3376745 - 120 15610154 esxQ Rv3017c - VI nonessential Esat-6 like protein esxQ (TB12.9) (Esat-6 like protein 8) KEEP 3376490..3376852 3376746 3376809 - 120 15610154 esxQ Rv3017c - VI nonessential Esat-6 like protein esxQ (TB12.9) (Esat-6 like protein 8) Only Marin et al 2022 KEEP 3376490..3376852 3376810 3376852 - 120 15610154 esxQ Rv3017c - VI nonessential Esat-6 like protein esxQ (TB12.9) (Esat-6 like protein 8) KEEP 3376853..3376938 3376853 3376920 I NA NA IG3066_Rv3017c-Rv3018c KEEP 3376853..3376938 3376921 3376938 I NA NA IG3066_Rv3017c-Rv3018c Annotation + Marin et al 2022 DISCARD 3376939..3378243 3376939 3377368 - 434 57117045 PPE46 Rv3018c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3376939..3378243 3377369 3377644 - 434 57117045 PPE46 Rv3018c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3376939..3378243 3377645 3378243 - 434 57117045 PPE46 Rv3018c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3378244..3378328 3378244 3378276 I NA NA IG3067_Rv3018c-Rv3018A repeat Annotation + Marin et al 2022 DISCARD 3378244..3378328 3378277 3378328 I NA NA IG3067_Rv3018c-Rv3018A repeat KEEP 3378329..3378415 3378329 3378415 - 28 57117046 PE27A Rv3018A - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 3378416..3378710 3378416 3378443 I NA NA IG3068_Rv3018A-Rv3019c Annotation + Marin et al 2022 DISCARD 3378416..3378710 3378444 3378710 I NA NA IG3068_Rv3018A-Rv3019c KEEP 3378711..3379001 3378711 3378894 - 96 15610156 esxR Rv3019c COG4842S II.C.2 nonessential secreted ESAT-6 like protein ESXR (TB10.3) (ESAT-6 like protein 9) KEEP 3378711..3379001 3378895 3378960 - 96 15610156 esxR Rv3019c COG4842S II.C.2 nonessential secreted ESAT-6 like protein ESXR (TB10.3) (ESAT-6 like protein 9) Only Marin et al 2022 KEEP 3378711..3379001 3378961 3379001 - 96 15610156 esxR Rv3019c COG4842S II.C.2 nonessential secreted ESAT-6 like protein ESXR (TB10.3) (ESAT-6 like protein 9) KEEP 3379002..3379035 3379002 3379035 I NA NA IG3069_Rv3019c-Rv3020c KEEP 3379036..3379329 3379036 3379195 - 97 57117047 esxS Rv3020c - VI nonessential Esat-6 like protein esxS KEEP 3379036..3379329 3379196 3379285 - 97 57117047 esxS Rv3020c - VI nonessential Esat-6 like protein esxS Only Marin et al 2022 KEEP 3379036..3379329 3379286 3379329 - 97 57117047 esxS Rv3020c - VI nonessential Esat-6 like protein esxS KEEP 3379330..3379375 3379330 3379357 I NA NA IG3070_Rv3020c-Rv3021c KEEP 3379330..3379375 3379358 3379375 I NA NA IG3070_Rv3020c-Rv3021c Annotation + Marin et al 2022 DISCARD 3379376..3380452 3379376 3380452 - 358 57117048 PPE47 Rv3021c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3380440..3380682 3380440 3380682 - 80 57117049 PPE48 Rv3022c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3380679..3380993 3380679 3380715 - 104 57117050 PE29 Rv3022A - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 3380679..3380993 3380716 3380906 - 104 57117050 PE29 Rv3022A - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 3380679..3380993 3380907 3380993 - 104 57117050 PE29 Rv3022A - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 3380994..3381374 3380994 3381021 I NA NA IG3073_Rv3022A-Rv3023c repeat Annotation + Marin et al 2022 DISCARD 3380994..3381374 3381022 3381306 I NA NA IG3073_Rv3022A-Rv3023c repeat KEEP 3380994..3381374 3381307 3381374 I NA NA IG3073_Rv3022A-Rv3023c repeat Annotation + Marin et al 2022 DISCARD 3381375..3382622 3381375 3382622 - 415 15610160 - Rv3023c COG3328L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3382623..3382784 3382623 3382755 I NA NA IG3074_Rv3023c-Rv3024c Annotation + Marin et al 2022 DISCARD 3382623..3382784 3382756 3382784 I NA NA IG3074_Rv3023c-Rv3024c KEEP 3382785..3383888 3382785 3383888 - 367 15610161 trmU Rv3024c COG0482J IV.H nonessential tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase KEEP 3383885..3385066 3383885 3385066 - 393 15610162 iscS Rv3025c COG1104E VII essential cysteine desulfurase IscS KEEP 3385067..3385162 3385067 3385162 I NA NA IG3076_Rv3025c-Rv3026c KEEP 3385163..3386077 3385163 3386077 - 304 15610163 - Rv3026c COG0204I V nonessential hypothetical protein KEEP 3386074..3386814 3386074 3386814 - 246 15610164 - Rv3027c COG3176R V nonessential hypothetical protein KEEP 3386815..3387074 3386815 3387074 I NA NA IG3078_Rv3027c-Rv3028c KEEP 3387075..3388031 3387075 3388031 - 318 15610165 fixB Rv3028c COG2025C I.B.6c nonessential electron transfer flavoprotein subunit alpha KEEP 3388032..3388069 3388032 3388069 I NA NA IG3079_Rv3028c-Rv3029c KEEP 3388070..3388870 3388070 3388870 - 266 15610166 fixA Rv3029c COG2086C I.B.6c essential electron transfer flavoprotein subunit beta KEEP 3388871..3389100 3388871 3389100 I NA NA IG3080_Rv3029c-Rv3030 KEEP 3389101..3389925 3389101 3389925 + 274 15610167 - Rv3030 COG0500QR V essential hypothetical protein KEEP 3389922..3391502 3389922 3391502 + 526 15610168 - Rv3031 COG1543S V essential hypothetical protein KEEP 3391503..3391533 3391503 3391533 I NA NA IG3082_Rv3031-Rv3032 KEEP 3391534..3392778 3391534 3392778 + 414 15610169 - Rv3032 COG0438M IV.H essential transferase KEEP 3392779..3393379 3392779 3393379 I NA NA IG3083_Rv3032-Rv3033 KEEP 3393380..3393928 3393380 3393928 + 182 15610170 - Rv3033 - VI nonessential hypothetical protein KEEP 3393929..3394018 3393929 3394018 I NA NA IG3084_Rv3033-Rv3034c KEEP 3394019..3394921 3394019 3394921 - 300 15610171 - Rv3034c COG0110R IV.H nonessential transferase KEEP 3394922..3395378 3394922 3395378 I NA NA IG3085_Rv3034c-Rv3035 KEEP 3395379..3396461 3395379 3396461 + 360 15610172 - Rv3035 COG1520S V nonessential hypothetical protein KEEP 3396458..3397141 3396458 3397141 - 227 15610173 TB22.2 Rv3036c - II.C.2 nonessential hypothetical protein KEEP 3397142..3397213 3397142 3397213 I NA NA IG3087_Rv3036c-Rv3037c KEEP 3397214..3398290 3397214 3398290 - 358 15610174 - Rv3037c COG0500QR V nonessential hypothetical protein KEEP 3398291..3398424 3398291 3398424 I NA NA IG3088_Rv3037c-Rv3038c KEEP 3398425..3399408 3398425 3399408 - 327 15610175 - Rv3038c COG0500QR V nonessential hypothetical protein KEEP 3399409..3399418 3399409 3399418 I NA NA IG3089_Rv3038c-Rv3039c KEEP 3399419..3400183 3399419 3400183 - 254 15610176 echA17 Rv3039c COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 3400184..3400191 3400184 3400191 I NA NA IG3090_Rv3039c-Rv3040c KEEP 3400192..3401058 3400192 3401058 - 288 15610177 - Rv3040c COG0494LR V nonessential hypothetical protein KEEP 3401055..3401918 3401055 3401918 - 287 15610178 - Rv3041c COG1119P III.A nonessential ABC transporter ATP-binding protein KEEP 3401919..3401932 3401919 3401932 I NA NA IG3092_Rv3041c-Rv3042c KEEP 3401933..3403162 3401933 3403162 - 409 15610179 serB2 Rv3042c COG0560E,COG3830T I.D.3 essential phosphoserine phosphatase KEEP 3403163..3403199 3403163 3403199 I NA NA IG3093_Rv3042c-Rv3043c KEEP 3403200..3404921 3403200 3404921 - 573 15610180 ctaD Rv3043c COG0843C I.B.6a essential cytochrome C oxidase polypeptide I KEEP 3404922..3405135 3404922 3405135 I NA NA IG3094_Rv3043c-Rv3044 KEEP 3405136..3406215 3405136 3406215 + 359 15610181 fecB Rv3044 COG0614P III.A.2 nonessential FEIII-dicitrate-binding periplasmic lipoprotein KEEP 3406216..3406284 3406216 3406284 I NA NA IG3095_Rv3044-Rv3045 KEEP 3406285..3407325 3406285 3407325 + 346 15610182 adhC Rv3045 COG1064R I.B.7 nonessential NADP-dependent alcohol dehydrogenase ADHC KEEP 3407314..3407688 3407314 3407688 - 124 15610183 - Rv3046c - V nonessential hypothetical protein KEEP 3407689..3408021 3407689 3408021 I NA NA IG3097_Rv3046c-Rv3047c KEEP 3408022..3408306 3408022 3408306 - 94 15610184 - Rv3047c - VI nonessential hypothetical protein KEEP 3408307..3408403 3408307 3408403 I NA NA IG3098_Rv3047c-Rv3048c KEEP 3408404..3409378 3408404 3409378 - 324 57117051 nrdF Rv3048c COG0208F I.F.3 essential ribonucleotide-diphosphate reductase subunit beta KEEP 3409379..3409508 3409379 3409508 I NA NA IG3099_Rv3048c-Rv3049c KEEP 3409509..3411083 3409509 3411083 - 524 15610186 - Rv3049c COG2072P VI nonessential monooxygenase KEEP 3411084..3411216 3411084 3411216 I NA NA IG3100_Rv3049c-Rv3050c KEEP 3411217..3411957 3411217 3411957 - 246 15610187 - Rv3050c COG1309K I.J.1 essential AsnC family transcriptional regulator KEEP 3411958..3412084 3411958 3412084 I NA NA IG3101_Rv3050c-Rv3051c KEEP 3412085..3414166 3412085 3414166 - 693 15610188 nrdE Rv3051c COG0209F I.F.3 essential ribonucleotide-diphosphate reductase subunit alpha KEEP 3414167..3414231 3414167 3414231 I NA NA IG3102_Rv3051c-Rv3052c KEEP 3414232..3414684 3414232 3414684 - 150 15610189 nrdI Rv3052c COG1780F I.F.3 nonessential ribonucleotide reductase stimulatory protein KEEP 3414685..3414718 3414685 3414718 I NA NA IG3103_Rv3052c-Rv3053c KEEP 3414719..3414958 3414719 3414958 - 79 15610190 nrdH Rv3053c COG0695O I.F.3 nonessential glutaredoxin electron transport protein NrdH KEEP 3414959..3415434 3414959 3415196 I NA NA IG3104_Rv3053c-Rv3054c KEEP 3414959..3415434 3415197 3415211 I NA NA IG3104_Rv3053c-Rv3054c Only Marin et al 2022 KEEP 3414959..3415434 3415212 3415434 I NA NA IG3104_Rv3053c-Rv3054c KEEP 3415435..3415989 3415435 3415989 - 184 15610191 - Rv3054c COG0431R V nonessential hypothetical protein KEEP 3415990..3416080 3415990 3416080 I NA NA IG3105_Rv3054c-Rv3055 KEEP 3416081..3416695 3416081 3416695 + 204 15610192 - Rv3055 - I.J.1 nonessential TetR family transcriptional regulator KEEP 3416696..3416704 3416696 3416704 I NA NA IG3106_Rv3055-Rv3056 KEEP 3416705..3417745 3416705 3417745 + 346 15610193 dinP Rv3056 COG0389L II.A.5 nonessential DNA polymerase IV KEEP 3417746..3417798 3417746 3417798 I NA NA IG3107_Rv3056-Rv3057c KEEP 3417799..3418662 3417799 3418662 - 287 15610194 - Rv3057c COG1028IQR VI nonessential short chain dehydrogenase KEEP 3418663..3418725 3418663 3418725 I NA NA IG3108_Rv3057c-Rv3058c KEEP 3418726..3419376 3418726 3419376 - 216 15610195 - Rv3058c COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 3419377..3419491 3419377 3419491 I NA NA IG3109_Rv3058c-Rv3059 KEEP 3419492..3420970 3419492 3420970 + 492 15610196 cyp136 Rv3059 COG2124Q IV.F nonessential cytochrome P450 136 KEEP 3420971..3421740 3420971 3421740 I NA NA IG3110_Rv3059-Rv3060c KEEP 3421741..3423213 3421741 3423213 - 490 15610197 - Rv3060c COG2186K I.J.1 nonessential GntR family transcriptional regulator KEEP 3423214..3423261 3423214 3423261 I NA NA IG3111_Rv3060c-Rv3061c KEEP 3423262..3425427 3423262 3425427 - 721 15610198 fadE22 Rv3061c COG1960I I.A.3 essential acyl-CoA dehydrogenase FADE22 KEEP 3425428..3425583 3425428 3425583 I NA NA IG3112_Rv3061c-Rv3062 KEEP 3425584..3427107 3425584 3427107 + 507 15610199 ligB Rv3062 COG1793L II.A.5 nonessential ATP-dependent DNA ligase KEEP 3427108..3427242 3427108 3427242 I NA NA IG3113_Rv3062-Rv3063 KEEP 3427243..3429519 3427243 3429519 + 758 15610200 cstA Rv3063 COG1966T III.E nonessential carbon starvation protein A CstA KEEP 3429520..3429824 3429520 3429824 I NA NA IG3114_Rv3063-Rv3064c KEEP 3429825..3430250 3429825 3430250 - 141 15610201 - Rv3064c COG2259S II.C.5 nonessential integral membrane protein KEEP 3430251..3430386 3430251 3430331 I NA NA IG3115_Rv3064c-Rv3065 KEEP 3430251..3430386 3430332 3430386 I NA NA IG3115_Rv3064c-Rv3065 Only Marin et al 2022 KEEP 3430387..3430710 3430387 3430388 + 107 57117052 mmr Rv3065 COG2076P III.A.6 nonessential multidrugs-transport integral membrane protein MMR Only Marin et al 2022 KEEP 3430387..3430710 3430389 3430710 + 107 57117052 mmr Rv3065 COG2076P III.A.6 nonessential multidrugs-transport integral membrane protein MMR KEEP 3430707..3431315 3430707 3431315 + 202 15610203 - Rv3066 COG3226S I.J.1 nonessential DeoR family transcriptional regulator KEEP 3431316..3431427 3431316 3431427 I NA NA IG3117_Rv3066-Rv3067 KEEP 3431428..3431838 3431428 3431838 + 136 15610204 - Rv3067 COG0473CE V nonessential hypothetical protein KEEP 3431839..3431978 3431839 3431978 I NA NA IG3118_Rv3067-Rv3068c KEEP 3431979..3433622 3431979 3433622 - 547 15610205 pgmA Rv3068c COG0033G I.A.1 nonessential phosphoglucomutase KEEP 3433623..3433691 3433623 3433691 I NA NA IG3119_Rv3068c-Rv3069 KEEP 3433692..3434090 3433692 3434090 + 132 15610206 ccrB Rv3069 COG0239D II.C.5 nonessential camphor resistance protein CrcB KEEP 3434087..3434467 3434087 3434467 + 126 15610207 ccrB Rv3070 COG0239D II.C.5 nonessential camphor resistance protein CrcB KEEP 3434464..3435573 3434464 3435573 + 369 15610208 - Rv3071 COG1993S V nonessential hypothetical protein KEEP 3435574..3435797 3435574 3435797 I NA NA IG3122_Rv3071-Rv3072c KEEP 3435798..3436322 3435798 3436322 - 174 15610209 - Rv3072c COG2141C V nonessential hypothetical protein KEEP 3436323..3436328 3436323 3436328 I NA NA IG3123_Rv3072c-Rv3073c KEEP 3436329..3436685 3436329 3436685 - 118 15610210 - Rv3073c COG3189S V nonessential hypothetical protein KEEP 3436686..3436778 3436686 3436778 I NA NA IG3124_Rv3073c-Rv3074 KEEP 3436779..3438053 3436779 3438053 + 424 15610211 - Rv3074 COG1403V V nonessential hypothetical protein KEEP 3438050..3438973 3438050 3438973 - 307 15610212 - Rv3075c COG2301G V nonessential hypothetical protein KEEP 3438974..3439071 3438974 3439071 I NA NA IG3126_Rv3075c-Rv3076 KEEP 3439072..3439548 3439072 3439548 + 158 15610213 - Rv3076 - V nonessential hypothetical protein KEEP 3439541..3441352 3439541 3441352 + 603 57117053 - Rv3077 COG3119P I.C.5 nonessential hydrolase KEEP 3441353..3441754 3441353 3441754 + 133 15610215 hab Rv3078 - VII nonessential hydroxylaminobenzene mutase HAB KEEP 3441755..3441769 3441755 3441769 I NA NA IG3129_Rv3078-Rv3079c KEEP 3441770..3442597 3441770 3442597 - 275 15610216 - Rv3079c COG2141C V nonessential hypothetical protein KEEP 3442598..3442655 3442598 3442655 I NA NA IG3130_Rv3079c-Rv3080c KEEP 3442656..3445988 3442656 3445988 - 1110 15610217 pknK Rv3080c COG0515RTKL,COG2909K I.J.3 nonessential serine/threonine-protein kinase transcriptional regulatory protein KEEP 3445989..3446039 3445989 3446039 I NA NA IG3131_Rv3080c-Rv3081 KEEP 3446040..3447278 3446040 3447278 + 412 15610218 - Rv3081 - V nonessential hypothetical protein KEEP 3447279..3447403 3447279 3447403 I NA NA IG3132_Rv3081-Rv3082c KEEP 3447404..3448426 3447404 3448426 - 340 15610219 virS Rv3082c COG2207K I.J.1 nonessential virulence-regulating transcriptional regulator VirS KEEP 3448427..3448503 3448427 3448503 I NA NA IG3133_Rv3082c-Rv3083 KEEP 3448504..3449991 3448504 3449991 + 495 15610220 - Rv3083 COG2072P VI nonessential monooxygenase KEEP 3449992..3449996 3449992 3449996 I NA NA IG3134_Rv3083-Rv3084 KEEP 3449997..3450923 3449997 3450923 + 308 15610221 lipR Rv3084 COG0657I II.B.5 nonessential acetyl-hydrolase/esterase LipR KEEP 3450920..3451750 3450920 3451378 + 276 15610222 - Rv3085 COG1028IQR VI nonessential short-chain type dehydrogenase/reductase KEEP 3450920..3451750 3451379 3451439 + 276 15610222 - Rv3085 COG1028IQR VI nonessential short-chain type dehydrogenase/reductase Only Marin et al 2022 KEEP 3450920..3451750 3451440 3451750 + 276 15610222 - Rv3085 COG1028IQR VI nonessential short-chain type dehydrogenase/reductase KEEP 3451751..3451780 3451751 3451780 I NA NA IG3136_Rv3085-Rv3086 KEEP 3451781..3452887 3451781 3452887 + 368 15610223 adhD Rv3086 COG1062C VI nonessential zinc-type alcohol dehydrogenase AdhD KEEP 3452888..3452924 3452888 3452924 I NA NA IG3137_Rv3086-Rv3087 KEEP 3452925..3454343 3452925 3454343 + 472 15610224 - Rv3087 - V essential hypothetical protein KEEP 3454340..3455764 3454340 3455764 + 474 15610225 - Rv3088 - V nonessential hypothetical protein KEEP 3455761..3457272 3455761 3457272 + 503 15610226 fadD13 Rv3089 COG0318IQ I.A.3 nonessential chain-fatty-acid-CoA ligase KEEP 3457273..3458210 3457273 3458210 I NA NA IG3140_Rv3089-Rv3090 KEEP 3458211..3459098 3458211 3459098 + 295 15610227 - Rv3090 COG0330O VI nonessential hypothetical protein KEEP 3459099..3459115 3459099 3459115 I NA NA IG3141_Rv3090-Rv3091 KEEP 3459116..3460807 3459116 3460807 + 563 15610228 - Rv3091 - V nonessential hypothetical protein KEEP 3460808..3460813 3460808 3460813 I NA NA IG3142_Rv3091-Rv3092c KEEP 3460814..3461734 3460814 3461734 - 306 15610229 - Rv3092c COG2354S II.C.5 nonessential integral membrane protein KEEP 3461735..3461759 3461735 3461759 I NA NA IG3143_Rv3092c-Rv3093c KEEP 3461760..3462764 3461760 3462764 - 334 15610230 - Rv3093c COG2141C VI nonessential oxidoreductase KEEP 3462761..3463891 3462761 3463547 - 376 15610231 - Rv3094c COG1960I V nonessential hypothetical protein KEEP 3462761..3463891 3463548 3463559 - 376 15610231 - Rv3094c COG1960I V nonessential hypothetical protein Only Marin et al 2022 KEEP 3462761..3463891 3463560 3463891 - 376 15610231 - Rv3094c COG1960I V nonessential hypothetical protein KEEP 3463892..3463972 3463892 3463972 I NA NA IG3145_Rv3094c-Rv3095 KEEP 3463973..3464449 3463973 3464449 + 158 15610232 - Rv3095 COG1733K I.J.1 nonessential putative transcriptional regulatory protein KEEP 3464450..3464546 3464450 3464546 I NA NA IG3146_Rv3095-Rv3096 KEEP 3464547..3465686 3464547 3465686 + 379 15610233 - Rv3096 - V nonessential hypothetical protein KEEP 3465687..3465777 3465687 3465777 I NA NA IG3147_Rv3096-Rv3097c KEEP 3465778..3467091 3465778 3467091 - 437 57117054 PE_PGRS63 Rv3097c COG0657I IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3467092..3467209 3467092 3467209 I NA NA IG3148_Rv3097c-Rv3098c KEEP 3467210..3467662 3467210 3467662 - 150 15610235 - Rv3098c COG4992E VI nonessential hypothetical protein KEEP 3467663..3468412 3467663 3468412 I NA NA IG3149_Rv3098c-Rv3099c KEEP 3468413..3469264 3468413 3469264 - 283 15610236 - Rv3099c - V nonessential hypothetical protein KEEP 3469265..3469300 3469265 3469300 I NA NA IG3150_Rv3099c-Rv3100c KEEP 3469301..3469783 3469301 3469783 - 160 15610237 smpB Rv3100c COG0691O IV.A nonessential SsrA-binding protein KEEP 3469784..3469785 3469784 3469785 I NA NA IG3151_Rv3100c-Rv3101c KEEP 3469786..3470679 3469786 3470679 - 297 15610238 ftsX Rv3101c COG2177D III.C essential putative cell division protein FTSX (septation component-transport integral membrane protein ABC transporter) KEEP 3470680..3471369 3470680 3471369 - 229 15610239 ftsE Rv3102c COG2884D III.C nonessential putative cell division ATP-binding protein FTSE (septation component-transport ATP-binding protein ABC transporter) KEEP 3471370..3471412 3471370 3471412 I NA NA IG3153_Rv3102c-Rv3103c KEEP 3471413..3471850 3471413 3471850 - 145 15610240 - Rv3103c - VI essential hypothetical protein KEEP 3471852..3472778 3471852 3472778 - 308 15610241 - Rv3104c COG0668M II.C.5 nonessential transmembrane protein KEEP 3472768..3473904 3472768 3473904 - 378 15610242 prfB Rv3105c COG1186J II.A.6 essential peptide chain release factor 2 KEEP 3473905..3474006 3473905 3474006 I NA NA IG3156_Rv3105c-Rv3106 KEEP 3474007..3475377 3474007 3475377 + 456 15610243 fprA Rv3106 COG0493ER I.B.6c nonessential NADPH:adrenodoxin oxidoreductase FPRA (NADPH-ferredoxin reductase) KEEP 3475378..3476961 3475378 3476961 - 527 15610244 agpS Rv3107c COG0277C I.B.7 nonessential alkyldihydroxyacetonephosphate synthase AgpS KEEP 3476962..3477059 3476962 3477059 I NA NA IG3158_Rv3107c-Rv3108 KEEP 3477060..3477500 3477060 3477288 + 146 15610245 - Rv3108 - VI nonessential hypothetical protein KEEP 3477060..3477500 3477289 3477404 + 146 15610245 - Rv3108 - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 3477060..3477500 3477405 3477500 + 146 15610245 - Rv3108 - VI nonessential hypothetical protein KEEP 3477501..3477648 3477501 3477648 I NA NA IG3159_Rv3108-Rv3109 KEEP 3477649..3478728 3477649 3478728 + 359 57117055 moaA1 Rv3109 COG2896H I.G.4 essential molybdenum cofactor biosynthesis protein A KEEP 3478729..3478778 3478729 3478778 I NA NA IG3160_Rv3109-Rv3110 KEEP 3478779..3479174 3478779 3479174 + 131 57117056 moaB1 Rv3110 COG2154H I.G.4 nonessential pterin-4-alpha-carbinolamine dehydratase MoaB1 KEEP 3479171..3479683 3479171 3479683 + 170 57117057 moaC Rv3111 COG0315H I.G.4 essential molybdenum cofactor biosynthesis protein C KEEP 3479684..3479699 3479684 3479699 I NA NA IG3162_Rv3111-Rv3112 KEEP 3479700..3479951 3479700 3479951 + 83 57117058 moaD1 Rv3112 COG1977H I.G.4 essential molybdenum cofactor biosynthesis protein D KEEP 3479952..3480073 3479952 3480073 I NA NA IG3163_Rv3112-Rv3113 KEEP 3480074..3480742 3480074 3480742 + 222 15610250 - Rv3113 COG0546R IV.I essential phosphatase KEEP 3480743..3480758 3480743 3480758 I NA NA IG3164_Rv3113-Rv3114 KEEP 3480759..3481289 3480759 3481289 + 176 15610251 - Rv3114 COG0590FJ V essential hypothetical protein KEEP 3481290..3481450 3481290 3481317 I NA NA IG3165_Rv3114-Rv3115 KEEP 3481290..3481450 3481318 3481450 I NA NA IG3165_Rv3114-Rv3115 Annotation + Marin et al 2022 DISCARD 3481451..3482698 3481451 3482698 + 415 15610252 - Rv3115 COG3328L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3482699..3482775 3482699 3482769 I NA NA IG3166_Rv3115-Rv3116 Annotation + Marin et al 2022 DISCARD 3482699..3482775 3482770 3482775 I NA NA IG3166_Rv3115-Rv3116 KEEP 3482776..3483945 3482776 3483941 + 389 57117059 moeB2 Rv3116 COG0476H,COG0607P I.G.4 nonessential molybdenum cofactor biosynthesis protein MoeB KEEP 3482776..3483945 3483942 3483945 + 389 57117059 moeB2 Rv3116 COG0476H,COG0607P I.G.4 nonessential molybdenum cofactor biosynthesis protein MoeB Only Marin et al 2022 KEEP 3483946..3483973 3483946 3483973 I NA NA IG3167_Rv3116-Rv3117 Only Marin et al 2022 KEEP 3483974..3484807 3483974 3484807 + 277 15610254 cysA3 Rv3117 COG2897P I.D.3 nonessential thiosulfate sulfurtransferase CysA3 Marin et al 2022 + homoplasy analysis DISCARD 3484809..3485111 3484809 3485111 + 100 57117060 sseC1 Rv3118 - I.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 3485112..3485131 3485112 3485117 I NA NA IG3169_Rv3118-Rv3119 Only Marin et al 2022 KEEP 3485112..3485131 3485118 3485131 I NA NA IG3169_Rv3118-Rv3119 KEEP 3485132..3485575 3485132 3485575 + 147 57117061 moaE1 Rv3119 COG0314H I.G.4 nonessential molybdenum cofactor biosynthesis protein E KEEP 3485572..3486174 3485572 3486174 + 200 15610257 - Rv3120 COG0500QR V nonessential hypothetical protein KEEP 3486175..3486508 3486175 3486508 I NA NA IG3171_Rv3120-Rv3121 KEEP 3486509..3487711 3486509 3487711 + 400 15610258 cyp141 Rv3121 COG2124Q IV.F nonessential cytochrome P450 141 KEEP 3487712..3488088 3487712 3488088 I NA NA IG3172_Rv3121-Rv3122 KEEP 3488089..3488559 3488089 3488559 + 156 15610259 - Rv3122 - VI nonessential hypothetical protein KEEP 3488560..3488568 3488560 3488568 I NA NA IG3173_Rv3122-Rv3123 KEEP 3488569..3489063 3488569 3489063 + 164 15610260 - Rv3123 - VI nonessential hypothetical protein KEEP 3489064..3489505 3489064 3489505 I NA NA IG3174_Rv3123-Rv3124 DR-emb KEEP 3489506..3490375 3489506 3490375 + 289 15610261 - Rv3124 COG3629T I.J.1 DR-emb nonessential transcriptional regulatory protein KEEP 3490376..3490475 3490376 3490475 I NA NA IG3175_Rv3124-Rv3125c KEEP 3490476..3491651 3490476 3491172 - 391 57117062 PPE49 Rv3125c - IV.C.1 PE/PPE/PGRS/DR-emb nonessential PPE family protein KEEP 3490476..3491651 3491173 3491238 - 391 57117062 PPE49 Rv3125c - IV.C.1 PE/PPE/PGRS/DR-emb nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3490476..3491651 3491239 3491291 - 391 57117062 PPE49 Rv3125c - IV.C.1 PE/PPE/PGRS/DR-emb nonessential PPE family protein KEEP 3490476..3491651 3491292 3491383 - 391 57117062 PPE49 Rv3125c - IV.C.1 PE/PPE/PGRS/DR-emb nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3490476..3491651 3491384 3491604 - 391 57117062 PPE49 Rv3125c - IV.C.1 PE/PPE/PGRS/DR-emb nonessential PPE family protein KEEP 3490476..3491651 3491605 3491651 - 391 57117062 PPE49 Rv3125c - IV.C.1 PE/PPE/PGRS/DR-emb nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3491652..3491807 3491652 3491662 I NA NA IG3176_Rv3125c-Rv3126c Annotation + Marin et al 2022 DISCARD 3491652..3491807 3491663 3491744 I NA NA IG3176_Rv3125c-Rv3126c KEEP 3491652..3491807 3491745 3491807 I NA NA IG3176_Rv3125c-Rv3126c Annotation + Marin et al 2022 DISCARD 3491808..3492122 3491808 3491860 - 104 15610263 - Rv3126c - VI DR-emb nonessential hypothetical protein Only Marin et al 2022 KEEP 3491808..3492122 3491861 3492122 - 104 15610263 - Rv3126c - VI DR-emb nonessential hypothetical protein KEEP 3492123..3492146 3492123 3492146 I NA NA IG3177_Rv3126c-Rv3127 KEEP 3492147..3493181 3492147 3493181 + 344 15610264 - Rv3127 - V DR-emb nonessential hypothetical protein KEEP 3493182..3494659 3493182 3494659 I NA NA IG3178_Rv3127-Rv3129 KEEP 3494660..3494992 3494660 3494992 + 110 57117063 - Rv3129 - V nonessential hypothetical protein KEEP 3494975..3496366 3494975 3496366 - 463 15610266 - Rv3130c - V nonessential hypothetical protein KEEP 3496367..3496550 3496367 3496550 I NA NA IG3180_Rv3130c-Rv3131 KEEP 3496551..3497549 3496551 3497549 + 332 15610267 - Rv3131 - V essential hypothetical protein KEEP 3497529..3499265 3497529 3499265 - 578 15610268 devS Rv3132c COG2203T,COG4585T I.J.2 essential two component sensor histidine kinase DEVS KEEP 3499262..3499915 3499262 3499915 - 217 15610269 devR Rv3133c COG2197TK I.J.2 nonessential two component transcriptional regulatory protein DevR KEEP 3499916..3499942 3499916 3499942 I NA NA IG3183_Rv3133c-Rv3134c KEEP 3499943..3500749 3499943 3500749 - 268 15610270 - Rv3134c COG0589T V nonessential hypothetical protein KEEP 3500750..3501333 3500750 3501333 I NA NA IG3184_Rv3134c-Rv3135 KEEP 3501334..3501732 3501334 3501335 + 132 57117064 PPE50 Rv3135 - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3501334..3501732 3501336 3501732 + 132 57117064 PPE50 Rv3135 - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3501733..3501793 3501733 3501793 I NA NA IG3185_Rv3135-Rv3136 repeat KEEP 3501794..3502936 3501794 3502154 + 380 57117065 PPE51 Rv3136 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3501794..3502936 3502155 3502265 + 380 57117065 PPE51 Rv3136 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3501794..3502936 3502266 3502936 + 380 57117065 PPE51 Rv3136 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3502937..3503392 3502937 3503392 I NA NA IG3186_Rv3136-Rv3137 KEEP 3503393..3504175 3503393 3504175 + 260 15610273 - Rv3137 COG0483G IV.I essential monophosphatase KEEP 3504176..3504194 3504176 3504194 I NA NA IG3187_Rv3137-Rv3138 KEEP 3504195..3505283 3504195 3505283 + 362 15610274 pflA Rv3138 COG1180O IV.H nonessential pyruvate formate lyase activating protein PflA KEEP 3505284..3505362 3505284 3505362 I NA NA IG3188_Rv3138-Rv3139 DR-inh KEEP 3505363..3506769 3505363 3506769 + 468 15610275 fadE24 Rv3139 COG1960I I.A.3 DR-inh essential acyl-CoA dehydrogenase FADE24 KEEP 3506770..3506789 3506770 3506789 I NA NA IG3189_Rv3139-Rv3140 KEEP 3506790..3507995 3506790 3507995 + 401 15610276 fadE23 Rv3140 COG1960I I.A.3 essential acyl-CoA dehydrogenase FADE23 KEEP 3507996..3508094 3507996 3508094 I NA NA IG3190_Rv3140-Rv3141 KEEP 3508095..3509066 3508095 3509066 + 323 15610277 fadB4 Rv3141 COG0604CR I.A.3 nonessential NADPH quinone oxidoreductase KEEP 3509067..3509117 3509067 3509117 I NA NA IG3191_Rv3141-Rv3142c KEEP 3509118..3509546 3509118 3509546 - 142 15610278 - Rv3142c - VI nonessential hypothetical protein KEEP 3509547..3509653 3509547 3509653 I NA NA IG3192_Rv3142c-Rv3143 KEEP 3509654..3510055 3509654 3510055 + 133 15610279 - Rv3143 COG0784T I.J.2 nonessential response regulator KEEP 3510056..3510087 3510056 3510087 I NA NA IG3193_Rv3143-Rv3144c KEEP 3510088..3511317 3510088 3511317 - 409 57117066 PPE52 Rv3144c - VI PE/PPE/PGRS nonessential PPE family protein KEEP 3511318..3511681 3511318 3511681 I NA NA IG3194_Rv3144c-Rv3145 KEEP 3511682..3512068 3511682 3512068 + 128 15610281 nuoA Rv3145 COG0838C I.B.6a nonessential NADH dehydrogenase subunit A KEEP 3512069..3512076 3512069 3512076 I NA NA IG3195_Rv3145-Rv3146 KEEP 3512077..3512631 3512077 3512631 + 184 15610282 nuoB Rv3146 COG0377C I.B.6a nonessential NADH dehydrogenase subunit B KEEP 3512628..3513338 3512628 3513338 + 236 15610283 nuoC Rv3147 COG0852C I.B.6a nonessential NADH dehydrogenase subunit C KEEP 3513338..3514660 3513338 3514660 + 440 15610284 nuoD Rv3148 COG0649C I.B.6a nonessential NADH dehydrogenase subunit D KEEP 3514657..3515415 3514657 3515415 + 252 15610285 nuoE Rv3149 COG1905C I.B.6a nonessential NADH dehydrogenase subunit E KEEP 3515412..3516749 3515412 3516749 + 445 15610286 nuoF Rv3150 COG1894C I.B.6a nonessential NADH dehydrogenase I chain F KEEP 3516746..3519166 3516746 3519166 + 806 15610287 nuoG Rv3151 COG1034C I.B.6a nonessential NADH dehydrogenase subunit G KEEP 3519167..3519281 3519167 3519281 I NA NA IG3201_Rv3151-Rv3152 KEEP 3519282..3520514 3519282 3520514 + 410 15610288 nuoH Rv3152 COG1005C I.B.6a nonessential NADH dehydrogenase subunit H KEEP 3520507..3521142 3520507 3521142 + 211 15610289 nuoI Rv3153 COG1143C I.B.6a nonessential NADH dehydrogenase subunit I KEEP 3521139..3521927 3521139 3521927 + 262 15610290 nuoJ Rv3154 COG0839C I.B.6a nonessential NADH dehydrogenase subunit J KEEP 3521924..3522223 3521924 3522223 + 99 15610291 nuoK Rv3155 COG0713C I.B.6a nonessential NADH dehydrogenase subunit K KEEP 3522224..3522233 3522224 3522233 I NA NA IG3205_Rv3155-Rv3156 KEEP 3522234..3524135 3522234 3524135 + 633 15610292 nuoL Rv3156 COG1009CP I.B.6a nonessential NADH dehydrogenase subunit L KEEP 3524132..3525793 3524132 3524463 + 553 15610293 nuoM Rv3157 COG1008C I.B.6a nonessential NADH dehydrogenase subunit M KEEP 3524132..3525793 3524464 3524527 + 553 15610293 nuoM Rv3157 COG1008C I.B.6a nonessential NADH dehydrogenase subunit M Only Marin et al 2022 KEEP 3524132..3525793 3524528 3525793 + 553 15610293 nuoM Rv3157 COG1008C I.B.6a nonessential NADH dehydrogenase subunit M KEEP 3525790..3527385 3525790 3527385 + 531 15610294 nuoN Rv3158 COG1007C I.B.6a nonessential NADH dehydrogenase subunit N KEEP 3527386..3527390 3527386 3527390 I NA NA IG3208_Rv3158-Rv3159c KEEP 3527391..3529163 3527391 3528082 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528083 3528084 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528085 3528085 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528086 3528087 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528088 3528097 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528098 3528099 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528100 3528100 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528101 3528102 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528103 3528115 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528116 3528120 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528121 3528127 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528128 3528129 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528130 3528138 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528139 3528140 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528141 3528142 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528143 3528144 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528145 3528156 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528157 3528159 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528160 3528163 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528164 3528165 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528166 3528190 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528191 3528192 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528193 3528196 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528197 3528198 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3527391..3529163 3528199 3528673 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3527391..3529163 3528674 3529163 - 590 57117067 PPE53 Rv3159c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3529164..3529337 3529164 3529181 I NA NA IG3209_Rv3159c-Rv3160c Annotation + Marin et al 2022 DISCARD 3529164..3529337 3529182 3529337 I NA NA IG3209_Rv3159c-Rv3160c KEEP 3529338..3529979 3529338 3529979 - 213 15610296 - Rv3160c COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 3529980..3529989 3529980 3529989 I NA NA IG3210_Rv3160c-Rv3161c KEEP 3529990..3531138 3529990 3531138 - 382 15610297 - Rv3161c COG4638PR VI nonessential dioxygenase KEEP 3531139..3531207 3531139 3531207 I NA NA IG3211_Rv3161c-Rv3162c KEEP 3531208..3531645 3531208 3531645 - 145 15610298 - Rv3162c - III.A.2 nonessential integral membrane protein KEEP 3531642..3532913 3531642 3532913 - 423 15610299 - Rv3163c COG1721R VI nonessential hypothetical protein KEEP 3532914..3532942 3532914 3532942 I NA NA IG3213_Rv3163c-Rv3164c KEEP 3532943..3533905 3532943 3533905 - 320 15610300 moxR3 Rv3164c COG0714R I.J.1 nonessential methanol dehydrogenase transcriptional regulatory protein MoxR3 KEEP 3533906..3533912 3533906 3533912 I NA NA IG3214_Rv3164c-Rv3165c KEEP 3533913..3534395 3533913 3534395 - 160 15610301 - Rv3165c - VI nonessential hypothetical protein KEEP 3534392..3535351 3534392 3535351 - 319 15610302 - Rv3166c - V nonessential hypothetical protein KEEP 3535352..3535430 3535352 3535430 I NA NA IG3216_Rv3166c-Rv3167c KEEP 3535431..3536057 3535431 3536057 - 208 15610303 - Rv3167c COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 3536058..3536101 3536058 3536101 I NA NA IG3217_Rv3167c-Rv3168 KEEP 3536102..3537238 3536102 3537238 + 378 15610304 - Rv3168 COG3173R V essential hypothetical protein KEEP 3537238..3538362 3537238 3537802 + 374 15610305 - Rv3169 - V nonessential hypothetical protein KEEP 3537238..3538362 3537803 3537820 + 374 15610305 - Rv3169 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3537238..3538362 3537821 3538362 + 374 15610305 - Rv3169 - V nonessential hypothetical protein KEEP 3538363..3538504 3538363 3538504 I NA NA IG3219_Rv3169-Rv3170 KEEP 3538505..3539851 3538505 3539851 + 448 15610306 aofH Rv3170 COG1231E VII nonessential flavin-containing monoamine oxidase KEEP 3539846..3540745 3539846 3540745 - 299 15610307 hpx Rv3171c COG0596R III.F nonessential non-Heme haloperoxidase Hpx KEEP 3540746..3540881 3540746 3540881 I NA NA IG3221_Rv3171c-Rv3172c KEEP 3540882..3541364 3540882 3541364 - 160 15610308 - Rv3172c - VI nonessential hypothetical protein KEEP 3541365..3541442 3541365 3541442 I NA NA IG3222_Rv3172c-Rv3173c KEEP 3541443..3542045 3541443 3542045 - 200 15610309 - Rv3173c COG1309K I.J.1 nonessential TetR/ACRR family transcriptional regulator KEEP 3542046..3542137 3542046 3542137 I NA NA IG3223_Rv3173c-Rv3174 KEEP 3542138..3542845 3542138 3542845 + 235 15610310 - Rv3174 COG1028IQR VI nonessential short chain dehydrogenase KEEP 3542846..3542859 3542846 3542859 I NA NA IG3224_Rv3174-Rv3175 KEEP 3542860..3544347 3542860 3544347 + 495 15610311 - Rv3175 COG0154J IV.I nonessential amidase KEEP 3544344..3545300 3544344 3545300 - 318 57117068 mesT Rv3176c COG0596R II.B.5 nonessential epoxide hydrolase MesT KEEP 3545301..3545446 3545301 3545446 I NA NA IG3226_Rv3176c-Rv3177 KEEP 3545447..3546307 3545447 3546307 + 286 15610313 - Rv3177 COG0596R III.F essential peroxidase KEEP 3546308..3546437 3546308 3546437 I NA NA IG3227_Rv3177-Rv3178 KEEP 3546438..3546797 3546438 3546797 + 119 15610314 - Rv3178 - V essential hypothetical protein KEEP 3546798..3547617 3546798 3547617 I NA NA IG3228_Rv3178-Rv3179 KEEP 3547618..3548907 3547618 3548907 + 429 15610315 - Rv3179 COG1373R V nonessential hypothetical protein KEEP 3548908..3549253 3548908 3549253 I NA NA IG3229_Rv3179-Rv3180c KEEP 3549254..3549688 3549254 3549688 - 144 15610316 - Rv3180c COG1848R VI nonessential hypothetical protein KEEP 3549689..3549690 3549689 3549690 I NA NA IG3230_Rv3180c-Rv3181c KEEP 3549691..3550143 3549691 3550143 - 150 15610317 - Rv3181c COG0745TK,COG4118D V nonessential hypothetical protein KEEP 3550144..3550373 3550144 3550373 I NA NA IG3231_Rv3181c-Rv3182 KEEP 3550374..3550718 3550374 3550718 + 114 15610318 - Rv3182 COG4683S V nonessential hypothetical protein KEEP 3550715..3551044 3550715 3551044 + 109 15610319 - Rv3183 COG1396K I.J.1 nonessential transcriptional regulatory protein KEEP 3551045..3551280 3551045 3551222 I NA NA IG3233_Rv3183-Rv3184 KEEP 3551045..3551280 3551223 3551280 I NA NA IG3233_Rv3183-Rv3184 Annotation + Marin et al 2022 DISCARD 3551281..3551607 3551281 3551607 + 108 15610320 - Rv3184 COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3551604..3552542 3551604 3552542 + 312 15610321 - Rv3185 COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3552543..3552763 3552543 3552763 I NA NA IG3235_Rv3185-Rv3186 repeat Annotation + Marin et al 2022 DISCARD 3552764..3553090 3552764 3553090 + 108 15610322 - Rv3186 COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3553087..3554025 3553087 3554025 + 312 15610323 - Rv3187 COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3554026..3554297 3554026 3554075 I NA NA IG3237_Rv3187-Rv3188 Annotation + Marin et al 2022 DISCARD 3554026..3554297 3554076 3554297 I NA NA IG3237_Rv3187-Rv3188 KEEP 3554298..3554645 3554298 3554645 + 115 15610324 - Rv3188 - V nonessential hypothetical protein KEEP 3554642..3555262 3554642 3555262 + 206 15610325 - Rv3189 - V nonessential hypothetical protein KEEP 3555263..3555421 3555263 3555421 I NA NA IG3239_Rv3189-Rv3190c KEEP 3555422..3556687 3555422 3556687 - 421 15610326 - Rv3190c - VI nonessential hypothetical protein KEEP 3556688..3557310 3556688 3557310 I NA NA IG3240_Rv3190c-Rv3191c KEEP 3557311..3558345 3557311 3558345 - 344 15610327 - Rv3191c COG2826L IV.B.1 phage nonessential transposase KEEP 3558346..3559562 3558346 3558758 I NA NA IG3241_Rv3191c-Rv3192 KEEP 3558346..3559562 3558759 3558794 I NA NA IG3241_Rv3191c-Rv3192 Annotation + Marin et al 2022 DISCARD 3558346..3559562 3558795 3559562 I NA NA IG3241_Rv3191c-Rv3192 KEEP 3559563..3560024 3559563 3560024 + 153 15610328 - Rv3192 COG2141C V nonessential hypothetical protein KEEP 3560025..3560193 3560025 3560193 I NA NA IG3242_Rv3192-Rv3193c KEEP 3560194..3563172 3560194 3563172 - 992 15610329 - Rv3193c COG1615S II.C.5 nonessential hypothetical protein KEEP 3563173..3563263 3563173 3563263 I NA NA IG3243_Rv3193c-Rv3194c KEEP 3563264..3564286 3563264 3564286 - 340 15610330 - Rv3194c COG3480T VI nonessential hypothetical protein KEEP 3564287..3564363 3564287 3564363 I NA NA IG3244_Rv3194c-Rv3195 KEEP 3564364..3565782 3564364 3565782 + 472 15610331 - Rv3195 COG5282S V nonessential hypothetical protein KEEP 3565783..3565787 3565783 3565787 I NA NA IG3245_Rv3195-Rv3196 KEEP 3565788..3566687 3565788 3566687 + 299 15610332 - Rv3196 - V nonessential hypothetical protein KEEP 3566688..3566695 3566688 3566695 I NA NA IG3246_Rv3196-Rv3196A KEEP 3566696..3566896 3566696 3566896 - 66 57117069 - Rv3196A - VI nonessential hypothetical protein KEEP 3566897..3567023 3566897 3567023 I NA NA IG3247_Rv3196A-Rv3197 KEEP 3567024..3568367 3567024 3568367 + 447 15610333 - Rv3197 COG0661R III.A nonessential ABC transporter ATP-binding protein KEEP 3568368..3568400 3568368 3568400 I NA NA IG3248_Rv3197-Rv3197A KEEP 3568401..3568679 3568401 3568679 - 92 57117070 whiB7 Rv3197A - I.J.1 nonessential transcriptional regulatory protein WHIB-like WHIB7 KEEP 3568680..3569108 3568680 3569108 I NA NA IG3249_Rv3197A-Rv3198c KEEP 3569109..3571211 3569109 3571211 - 700 15610334 uvrD2 Rv3198c COG0210L VI essential ATP-dependent DNA helicase II UVRD2 KEEP 3571212..3571334 3571212 3571334 I NA NA IG3250_Rv3198c-Rv3198A KEEP 3571335..3571589 3571335 3571589 + 84 57117071 - Rv3198A COG0695O II.A.5 nonessential glutaredoxin protein KEEP 3571590..3571601 3571590 3571601 I NA NA IG3251_Rv3198A-Rv3199c KEEP 3571602..3572543 3571602 3572543 - 313 15610335 nudC Rv3199c COG2816L IV.I nonessential NADH pyrophosphatase KEEP 3572544..3572601 3572544 3572553 I NA NA IG3252_Rv3199c-Rv3200c KEEP 3572544..3572601 3572554 3572601 I NA NA IG3252_Rv3199c-Rv3200c Only Marin et al 2022 KEEP 3572602..3573669 3572602 3572610 - 355 15610336 - Rv3200c COG1226P II.C.5 nonessential transmembrane cation transporter Only Marin et al 2022 KEEP 3572602..3573669 3572611 3573669 - 355 15610336 - Rv3200c COG1226P II.C.5 nonessential transmembrane cation transporter KEEP 3573670..3573730 3573670 3573730 I NA NA IG3253_Rv3200c-Rv3201c KEEP 3573731..3577036 3573731 3577036 - 1101 15610337 - Rv3201c COG0210L,COG2887L II.A.5 essential ATP-dependent DNA helicase KEEP 3577033..3580200 3577033 3580200 - 1055 15610338 - Rv3202c COG0210L,COG2887L II.A.5 nonessential ATP-dependent DNA helicase KEEP 3580201..3580637 3580201 3580637 I NA NA IG3255_Rv3202c-Rv3203 KEEP 3580638..3581312 3580638 3581312 + 224 15610339 lipV Rv3203 COG0596R II.B.5 nonessential lipase LipV KEEP 3581313..3581314 3581313 3581314 I NA NA IG3256_Rv3203-Rv3204 KEEP 3581315..3581620 3581315 3581620 + 101 15610340 - Rv3204 COG3695L IV.H nonessential DNA-methyltransferase (modification methylase) KEEP 3581621..3581626 3581621 3581626 I NA NA IG3257_Rv3204-Rv3205c KEEP 3581627..3582505 3581627 3582505 - 292 15610341 - Rv3205c - V nonessential hypothetical protein KEEP 3582506..3582531 3582506 3582531 I NA NA IG3258_Rv3205c-Rv3206c KEEP 3582532..3583710 3582532 3583710 - 392 57117072 moeB1 Rv3206c COG0476H,COG0607P I.G.4 nonessential molybdopterin biosynthesis-like protein MoeZ KEEP 3583711..3583800 3583711 3583800 I NA NA IG3259_Rv3206c-Rv3207c KEEP 3583801..3584658 3583801 3584658 - 285 15610343 - Rv3207c - V nonessential hypothetical protein KEEP 3584659..3585003 3584659 3585003 I NA NA IG3260_Rv3207c-Rv3208 KEEP 3585004..3585690 3585004 3585690 + 228 15610344 - Rv3208 COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 3585677..3585949 3585677 3585949 - 90 57117073 TB9.4 Rv3208A - V nonessential hypothetical protein KEEP 3585950..3586273 3585950 3586273 I NA NA IG3262_Rv3208A-Rv3209 KEEP 3586274..3586834 3586274 3586834 + 186 15610345 - Rv3209 - V nonessential hypothetical protein KEEP 3586835..3586843 3586835 3586843 I NA NA IG3263_Rv3209-Rv3210c KEEP 3586844..3587539 3586844 3587539 - 231 15610346 - Rv3210c - V essential hypothetical protein KEEP 3587540..3587797 3587540 3587797 I NA NA IG3264_Rv3210c-Rv3211 KEEP 3587798..3589381 3587798 3589381 + 527 15610347 rhlE Rv3211 COG0513LKJ II.A.7 nonessential ATP-dependent RNA helicase RhlE KEEP 3589382..3589393 3589382 3589393 I NA NA IG3265_Rv3211-Rv3212 KEEP 3589394..3590617 3589394 3590617 + 407 15610348 - Rv3212 - V nonessential hypothetical protein KEEP 3590618..3590691 3590618 3590629 I NA NA IG3266_Rv3212-Rv3213c KEEP 3590618..3590691 3590630 3590687 I NA NA IG3266_Rv3212-Rv3213c Only Marin et al 2022 KEEP 3590618..3590691 3590688 3590691 I NA NA IG3266_Rv3212-Rv3213c KEEP 3590692..3591492 3590692 3591492 - 266 15610349 - Rv3213c COG1192D III.C nonessential SOJ/PARA-like protein KEEP 3591493..3591645 3591493 3591645 I NA NA IG3267_Rv3213c-Rv3214 KEEP 3591646..3592257 3591646 3592257 + 203 57117074 gpm2 Rv3214 COG0406G I.G.14 nonessential acid phosphatase KEEP 3592254..3593372 3592254 3593372 + 372 15610351 entC Rv3215 COG1169HQ I.G.14 nonessential isochorismate synthase KEEP 3593373..3593519 3593373 3593519 I NA NA IG3269_Rv3215-Rv3216 KEEP 3593520..3593852 3593520 3593852 + 110 15610352 - Rv3216 COG0454KR IV.H nonessential acetyltransferase KEEP 3593804..3594235 3593804 3594235 - 143 15610353 - Rv3217c - II.C.5 nonessential integral membrane protein KEEP 3594236..3594467 3594236 3594261 I NA NA IG3271_Rv3217c-Rv3218 KEEP 3594236..3594467 3594262 3594465 I NA NA IG3271_Rv3217c-Rv3218 Only Marin et al 2022 KEEP 3594236..3594467 3594466 3594467 I NA NA IG3271_Rv3217c-Rv3218 KEEP 3594468..3595433 3594468 3595433 + 321 15610354 - Rv3218 COG1597IR V nonessential hypothetical protein KEEP 3595434..3595712 3595434 3595712 I NA NA IG3272_Rv3218-Rv3219 KEEP 3595713..3595967 3595713 3595967 + 84 15610355 whiB1 Rv3219 - I.J.1 nonessential transcriptional regulatory protein WHIB-like WHIB1 KEEP 3595968..3596028 3595968 3595986 I NA NA IG3273_Rv3219-Rv3220c KEEP 3595968..3596028 3595987 3596005 I NA NA IG3273_Rv3219-Rv3220c Only Marin et al 2022 KEEP 3595968..3596028 3596006 3596028 I NA NA IG3273_Rv3219-Rv3220c KEEP 3596029..3597534 3596029 3597534 - 501 15610356 - Rv3220c COG3920T I.J.2 nonessential two component sensor kinase KEEP 3597535..3597550 3597535 3597550 I NA NA IG3274_Rv3220c-Rv3221c KEEP 3597551..3597766 3597551 3597766 - 71 15610357 TB7.3 Rv3221c COG0511I II.A.7 nonessential putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit KEEP 3597767..3598050 3597767 3598050 I NA NA IG3275_Rv3221c-Rv3221A KEEP 3598051..3598356 3598051 3598348 - 101 57117075 - Rv3221A COG0444EP I.H.1 nonessential anti-sigma factor KEEP 3598051..3598356 3598349 3598356 - 101 57117075 - Rv3221A COG0444EP I.H.1 nonessential anti-sigma factor Only Marin et al 2022 KEEP 3598353..3598904 3598353 3598405 - 183 15610358 - Rv3222c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3598353..3598904 3598406 3598435 - 183 15610358 - Rv3222c - V nonessential hypothetical protein KEEP 3598353..3598904 3598436 3598532 - 183 15610358 - Rv3222c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3598353..3598904 3598533 3598640 - 183 15610358 - Rv3222c - V nonessential hypothetical protein KEEP 3598353..3598904 3598641 3598719 - 183 15610358 - Rv3222c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3598353..3598904 3598720 3598904 - 183 15610358 - Rv3222c - V nonessential hypothetical protein KEEP 3598901..3599551 3598901 3599551 - 216 15610359 sigH Rv3223c COG1595K II.A.7 nonessential RNA polymerase sigma factor RpoE KEEP 3599552..3599850 3599552 3599850 I NA NA IG3278_Rv3223c-Rv3224 KEEP 3599851..3600699 3599851 3600699 + 282 15610360 - Rv3224 COG1028IQR VI nonessential short chain dehydrogenase KEEP 3600635..3600823 3600635 3600823 + 62 57117076 - Rv3224A - V nonessential hypothetical protein KEEP 3600801..3601019 3600801 3601019 + 72 57117077 - Rv3224B COG2606S V nonessential hypothetical protein KEEP 3601016..3602440 3601016 3602440 - 474 15610361 - Rv3225c COG1670J,COG3173R IV.D nonessential transferase KEEP 3602441..3602563 3602441 3602563 I NA NA IG3282_Rv3225c-Rv3226c KEEP 3602564..3603322 3602564 3603322 - 252 15610362 - Rv3226c COG2135S V nonessential hypothetical protein KEEP 3603323..3603376 3603323 3603376 I NA NA IG3283_Rv3226c-Rv3227 KEEP 3603377..3604729 3603377 3604729 + 450 15610363 aroA Rv3227 COG0128E I.D.4 nonessential 3-phosphoshikimate 1-carboxyvinyltransferase KEEP 3604726..3605718 3604726 3605718 + 330 15610364 - Rv3228 COG1162R V nonessential hypothetical protein KEEP 3605719..3605750 3605719 3605750 I NA NA IG3285_Rv3228-Rv3229c KEEP 3605751..3607034 3605751 3607034 - 427 57117078 - Rv3229c COG3239I I.H.2 essential linoleoyl-CoA desaturase KEEP 3607035..3607111 3607035 3607111 I NA NA IG3286_Rv3229c-Rv3230c KEEP 3607112..3608254 3607112 3608254 - 380 15610366 - Rv3230c COG1018C VI nonessential oxidoreductase KEEP 3608255..3608363 3608255 3608363 I NA NA IG3287_Rv3230c-Rv3231c KEEP 3608364..3608873 3608364 3608873 - 169 15610367 - Rv3231c - V nonessential hypothetical protein KEEP 3608870..3609757 3608870 3609757 - 295 15610368 pvdS Rv3232c COG2326S II.A.7 nonessential transcriptional regulatory protein PvdS KEEP 3609758..3609780 3609758 3609780 I NA NA IG3289_Rv3232c-Rv3233c KEEP 3609781..3610371 3609781 3610371 - 196 15610369 - Rv3233c - V nonessential hypothetical protein KEEP 3610372..3610373 3610372 3610373 I NA NA IG3290_Rv3233c-Rv3234c KEEP 3610374..3611189 3610374 3611189 - 271 15610370 - Rv3234c - V nonessential hypothetical protein KEEP 3611190..3611299 3611190 3611299 I NA NA IG3291_Rv3234c-Rv3235 KEEP 3611300..3611941 3611300 3611941 + 213 15610371 - Rv3235 - VI nonessential hypothetical protein KEEP 3611942..3611958 3611942 3611958 I NA NA IG3292_Rv3235-Rv3236c KEEP 3611959..3613116 3611959 3613116 - 385 57117079 - Rv3236c COG0475P III.A.2 essential integral membrane transport protein KEEP 3613117..3613120 3613117 3613120 I NA NA IG3293_Rv3236c-Rv3237c KEEP 3613121..3613603 3613121 3613603 - 160 15610373 - Rv3237c COG0490P III.A.2 nonessential hypothetical protein KEEP 3613604..3613663 3613604 3613663 I NA NA IG3294_Rv3237c-Rv3238c KEEP 3613664..3614398 3613664 3614398 - 244 15610374 - Rv3238c COG2020O II.C.5 nonessential integral membrane protein KEEP 3614399..3614456 3614399 3614456 I NA NA IG3295_Rv3238c-Rv3239c KEEP 3614457..3617603 3614457 3617101 - 1048 15610375 - Rv3239c COG0477GEPR,COG0664T,COG1752R II.C.5 nonessential transmembrane transport protein KEEP 3614457..3617603 3617102 3617103 - 1048 15610375 - Rv3239c COG0477GEPR,COG0664T,COG1752R II.C.5 nonessential transmembrane transport protein Only Marin et al 2022 KEEP 3614457..3617603 3617104 3617603 - 1048 15610375 - Rv3239c COG0477GEPR,COG0664T,COG1752R II.C.5 nonessential transmembrane transport protein KEEP 3617604..3617681 3617604 3617681 I NA NA IG3296_Rv3239c-Rv3240c KEEP 3617682..3620531 3617682 3620531 - 949 57117080 secA1 Rv3240c COG0653U III.D essential preprotein translocase subunit SecA KEEP 3620532..3620609 3620532 3620609 I NA NA IG3297_Rv3240c-Rv3241c KEEP 3620610..3621254 3620610 3621254 - 214 15610377 - Rv3241c COG1544J II.A.1 nonessential hypothetical protein KEEP 3621255..3621569 3621255 3621569 I NA NA IG3298_Rv3241c-Rv3242c KEEP 3621570..3622211 3621570 3622211 - 213 15610378 - Rv3242c COG1040R V nonessential hypothetical protein KEEP 3622212..3622248 3622212 3622248 I NA NA IG3299_Rv3242c-Rv3243c KEEP 3622249..3623091 3622249 3623091 - 280 15610379 - Rv3243c - VI essential hypothetical protein KEEP 3623092..3623158 3623092 3623158 I NA NA IG3300_Rv3243c-Rv3244c KEEP 3623159..3624910 3623159 3624910 - 583 15610380 lpqB Rv3244c - II.C.1 essential lipoprotein LpqB KEEP 3624910..3626613 3624910 3626605 - 567 15610381 mtrB Rv3245c COG0642T I.J.2 essential two component sensory transduction histidine kinase MTRB KEEP 3624910..3626613 3626606 3626613 - 567 15610381 mtrB Rv3245c COG0642T I.J.2 essential two component sensory transduction histidine kinase MTRB Only Marin et al 2022 KEEP 3626614..3626662 3626614 3626662 I NA NA IG3302_Rv3245c-Rv3246c Only Marin et al 2022 KEEP 3626663..3627349 3626663 3626667 - 228 15610382 mtrA Rv3246c COG0745TK I.J.2 essential two component sensory transduction transcriptional regulatory protein MTRA Only Marin et al 2022 KEEP 3626663..3627349 3626668 3627349 - 228 15610382 mtrA Rv3246c COG0745TK I.J.2 essential two component sensory transduction transcriptional regulatory protein MTRA KEEP 3627350..3627418 3627350 3627418 I NA NA IG3303_Rv3246c-Rv3247c KEEP 3627419..3628063 3627419 3628063 - 214 15610383 tmk Rv3247c COG0125F I.F.3 nonessential thymidylate kinase KEEP 3628064..3628159 3628064 3628083 I NA NA IG3304_Rv3247c-Rv3248c KEEP 3628064..3628159 3628084 3628147 I NA NA IG3304_Rv3247c-Rv3248c Only Marin et al 2022 KEEP 3628064..3628159 3628148 3628159 I NA NA IG3304_Rv3247c-Rv3248c KEEP 3628160..3629647 3628160 3629647 - 495 15610384 sahH Rv3248c COG0499H I.C.5 essential S-adenosyl-L-homocysteine hydrolase KEEP 3629648..3629751 3629648 3629751 I NA NA IG3305_Rv3248c-Rv3249c KEEP 3629752..3630387 3629752 3630387 - 211 15610385 - Rv3249c COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 3630384..3630566 3630384 3630566 - 60 15610386 rubB Rv3250c COG1773C I.B.6c nonessential rubredoxin RubB KEEP 3630567..3630570 3630567 3630570 I NA NA IG3307_Rv3250c-Rv3251c KEEP 3630571..3630738 3630571 3630738 - 55 15610387 rubA Rv3251c COG1773C I.B.6c nonessential rubredoxin RUBA KEEP 3630738..3631988 3630738 3631988 - 416 15610388 alkB Rv3252c - II.C.5 nonessential transmembrane alkane 1-monooxygenase AlkB KEEP 3631989..3632096 3631989 3632096 I NA NA IG3309_Rv3252c-Rv3253c KEEP 3632097..3633584 3632097 3633584 - 495 15610389 - Rv3253c COG0531E III.A.1 nonessential cationic amino acid transport integral membrane protein KEEP 3633585..3633674 3633585 3633674 I NA NA IG3310_Rv3253c-Rv3254 KEEP 3633675..3635063 3633675 3635063 + 462 15610390 - Rv3254 - V nonessential hypothetical protein KEEP 3635041..3636267 3635041 3636267 - 408 15610391 manA Rv3255c COG1482G I.A.1 essential mannose-6-phosphate isomerase KEEP 3636268..3636274 3636268 3636274 I NA NA IG3312_Rv3255c-Rv3256c KEEP 3636275..3637315 3636275 3637315 - 346 15610392 - Rv3256c - V nonessential hypothetical protein KEEP 3637312..3638709 3637312 3638709 - 465 15610393 manB Rv3257c COG1109G I.A.1 essential phosphomannomutase/phosphoglucomutase KEEP 3638710..3638810 3638710 3638810 I NA NA IG3314_Rv3257c-Rv3258c KEEP 3638811..3639302 3638811 3639302 - 163 15610394 - Rv3258c - V essential hypothetical protein KEEP 3639303..3639424 3639303 3639424 I NA NA IG3315_Rv3258c-Rv3259 KEEP 3639425..3639844 3639425 3639844 + 139 15610395 - Rv3259 COG2925L V nonessential hypothetical protein KEEP 3639845..3639871 3639845 3639871 I NA NA IG3316_Rv3259-Rv3260c KEEP 3639872..3640141 3639872 3640141 - 89 15610396 whiB2 Rv3260c - I.J.1 nonessential transcriptional regulatory protein WHIB-like WHIB2 KEEP 3640142..3640542 3640142 3640542 I NA NA IG3317_Rv3260c-Rv3261 KEEP 3640543..3641538 3640543 3641538 + 331 15610397 fbiA Rv3261 COG0391S IV.G nonessential LPPG:FO 2-phospho-L-lactate transferase KEEP 3641535..3642881 3641535 3642881 + 448 15610398 fbiB Rv3262 COG0778C,COG1478S IV.G nonessential F420-0--gamma-glutamyl ligase KEEP 3642882..3643176 3642882 3643176 I NA NA IG3319_Rv3262-Rv3263 KEEP 3643177..3644838 3643177 3644838 + 553 15610399 - Rv3263 COG0827L II.A.5 nonessential DNA methylase (modification methylase) (methyltransferase) KEEP 3644839..3644897 3644839 3644897 I NA NA IG3320_Rv3263-Rv3264c KEEP 3644898..3645977 3644898 3645977 - 359 57117081 manB Rv3264c COG1208MJ I.C.3 DR-emb essential D-alpha-D-mannose-1-phosphate guanylyltransferase MANB (D-alpha-D-heptose-1-phosphate guanylyltransferase) KEEP 3645979..3646884 3645979 3646884 - 301 57117082 wbbL1 Rv3265c COG1216R I.C.3 essential dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol KEEP 3646885..3646894 3646885 3646894 I NA NA IG3322_Rv3265c-Rv3266c KEEP 3646895..3647809 3646895 3647809 - 304 15610402 rmlD Rv3266c COG1091M I.C.3 nonessential dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD KEEP 3647810..3647884 3647810 3647884 I NA NA IG3323_Rv3266c-Rv3267 DR-emb KEEP 3647885..3649381 3647885 3649381 + 498 15610403 - Rv3267 COG1316K V essential hypothetical protein KEEP 3649382..3649419 3649382 3649419 I NA NA IG3324_Rv3267-Rv3268 KEEP 3649420..3650109 3649420 3650109 + 229 15610404 - Rv3268 - V nonessential hypothetical protein KEEP 3650110..3650233 3650110 3650233 I NA NA IG3325_Rv3268-Rv3269 KEEP 3650234..3650515 3650234 3650515 + 93 15610405 - Rv3269 - III.B nonessential hypothetical protein KEEP 3650516..3650525 3650516 3650525 I NA NA IG3326_Rv3269-Rv3270 KEEP 3650526..3652682 3650526 3652682 + 718 15610406 ctpC Rv3270 COG2217P III.A.2 essential metal cation-transporting P-type ATPase C CtpC KEEP 3652679..3653347 3652679 3653347 - 222 15610407 - Rv3271c - II.C.5 essential integral membrane protein KEEP 3653348..3653447 3653348 3653447 I NA NA IG3328_Rv3271c-Rv3272 KEEP 3653448..3654632 3653448 3654632 + 394 15610408 - Rv3272 COG1804C V nonessential hypothetical protein KEEP 3654633..3654636 3654633 3654636 I NA NA IG3329_Rv3272-Rv3273 KEEP 3654637..3656931 3654637 3656931 + 764 15610409 - Rv3273 COG0288P,COG0659P II.C.5 nonessential transmembrane carbonic anhydrase KEEP 3656920..3658089 3656920 3658089 - 389 15610410 fadE25 Rv3274c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE25 KEEP 3658090..3658113 3658090 3658113 I NA NA IG3331_Rv3274c-Rv3275c KEEP 3658114..3658638 3658114 3658634 - 174 15610411 purE Rv3275c COG0041F I.F.1 essential phosphoribosylaminoimidazole carboxylase catalytic subunit KEEP 3658114..3658638 3658635 3658638 - 174 15610411 purE Rv3275c COG0041F I.F.1 essential phosphoribosylaminoimidazole carboxylase catalytic subunit Only Marin et al 2022 KEEP 3658635..3659924 3658635 3658712 - 429 15610412 purK Rv3276c COG0026F I.F.1 nonessential phosphoribosylaminoimidazole carboxylase ATPase subunit Only Marin et al 2022 KEEP 3658635..3659924 3658713 3659924 - 429 15610412 purK Rv3276c COG0026F I.F.1 nonessential phosphoribosylaminoimidazole carboxylase ATPase subunit KEEP 3659878..3660696 3659878 3660696 + 272 15610413 - Rv3277 COG2246S II.C.5 essential transmembrane protein KEEP 3660651..3661169 3660651 3661169 - 172 15610414 - Rv3278c - II.C.5 nonessential transmembrane protein KEEP 3661170..3661211 3661170 3661211 I NA NA IG3335_Rv3278c-Rv3279c KEEP 3661212..3662012 3661212 3662012 - 266 15610415 birA Rv3279c COG0340H I.G.1 nonessential biotin--protein ligase KEEP 3662013..3662061 3662013 3662061 I NA NA IG3336_Rv3279c-Rv3280 KEEP 3662062..3663708 3662062 3663708 + 548 15610416 accD5 Rv3280 COG4799I I.H.1 nonessential propionyl-CoA carboxylase beta chain KEEP 3663689..3664222 3663689 3663722 + 177 15610417 - Rv3281 - V essential hypothetical protein KEEP 3663689..3664222 3663723 3664000 + 177 15610417 - Rv3281 - V essential hypothetical protein Only Marin et al 2022 KEEP 3663689..3664222 3664001 3664222 + 177 15610417 - Rv3281 - V essential hypothetical protein KEEP 3664219..3664887 3664219 3664887 + 222 15610418 maf Rv3282 COG0424D V nonessential Maf-like protein KEEP 3664888..3664927 3664888 3664927 I NA NA IG3339_Rv3282-Rv3283 KEEP 3664928..3665821 3664928 3665821 + 297 15610419 sseA Rv3283 COG2897P I.C.5 nonessential thiosulfate sulfurtransferase SseA KEEP 3665818..3666249 3665818 3666249 + 143 15610420 - Rv3284 COG2166R V nonessential hypothetical protein KEEP 3666250..3666356 3666250 3666356 I NA NA IG3341_Rv3284-Rv3285 KEEP 3666357..3668159 3666357 3668159 + 600 15610421 accA3 Rv3285 COG4770I I.H.1 essential bifunctional acetyl-/propionyl-coenzyme A carboxylase subunit alpha KEEP 3668160..3668168 3668160 3668168 I NA NA IG3342_Rv3285-Rv3286c KEEP 3668169..3668954 3668169 3668954 - 261 15610422 sigF Rv3286c COG1191K II.A.7 nonessential RNA polymerase sigma factor SigF KEEP 3668951..3669388 3668951 3669388 - 145 57117083 rsbW Rv3287c COG2172T II.A.7 nonessential anti-sigma factor rsbW (sigma negative effector) KEEP 3669389..3669585 3669389 3669585 I NA NA IG3344_Rv3287c-Rv3288c KEEP 3669586..3669999 3669586 3669999 - 137 15610424 usfY Rv3288c - VI nonessential hypothetical protein KEEP 3670000..3670033 3670000 3670033 I NA NA IG3345_Rv3288c-Rv3289c KEEP 3670034..3670411 3670034 3670411 - 125 15610425 - Rv3289c - II.C.5 nonessential transmembrane protein KEEP 3670412..3670444 3670412 3670444 I NA NA IG3346_Rv3289c-Rv3290c KEEP 3670445..3671794 3670445 3671794 - 449 15610426 lat Rv3290c COG0160E IV.D nonessential L-lysine aminotransferase KEEP 3671795..3671844 3671795 3671844 I NA NA IG3347_Rv3290c-Rv3291c KEEP 3671845..3672297 3671845 3672297 - 150 15610427 - Rv3291c COG1522K I.J.1 nonessential AsnC family transcriptional regulator KEEP 3672298..3672327 3672298 3672327 I NA NA IG3348_Rv3291c-Rv3292 KEEP 3672328..3673575 3672328 3673575 + 415 15610428 - Rv3292 COG5383S V nonessential hypothetical protein KEEP 3673576..3673601 3673576 3673601 I NA NA IG3349_Rv3292-Rv3293 KEEP 3673602..3675086 3673602 3675086 + 494 57117084 pcd Rv3293 COG1012C I.B.7 nonessential piperideine-6-carboxilic acid dehydrogenase KEEP 3675087..3675185 3675087 3675185 I NA NA IG3350_Rv3293-Rv3294c KEEP 3675186..3675995 3675186 3675995 - 269 57117085 - Rv3294c COG1373R V nonessential hypothetical protein KEEP 3675996..3676065 3675996 3676065 I NA NA IG3351_Rv3294c-Rv3295 KEEP 3676066..3676731 3676066 3676731 + 221 15610431 - Rv3295 COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 3676732..3676774 3676732 3676774 I NA NA IG3352_Rv3295-Rv3296 KEEP 3676775..3681316 3676775 3681316 + 1513 15610432 lhr Rv3296 COG1201R II.A.5 nonessential ATP-dependent helicase KEEP 3681317..3681319 3681317 3681319 I NA NA IG3353_Rv3296-Rv3297 KEEP 3681320..3682087 3681320 3682087 + 255 15610433 nei Rv3297 COG0266L II.A.5 nonessential endonuclease VIII KEEP 3682088..3682109 3682088 3682109 I NA NA IG3354_Rv3297-Rv3298c KEEP 3682110..3683024 3682110 3683024 - 304 15610434 lpqC Rv3298c COG3509Q II.C.1 nonessential esterase lipoprotein LpqC KEEP 3683025..3683050 3683025 3683050 I NA NA IG3355_Rv3298c-Rv3299c KEEP 3683051..3685963 3683051 3685963 - 970 15610435 atsB Rv3299c COG3119P I.C.5 nonessential arylsulfatase AtsB KEEP 3685964..3685982 3685964 3685982 I NA NA IG3356_Rv3299c-Rv3300c KEEP 3685983..3686900 3685983 3686900 - 305 15610436 - Rv3300c COG0564J I.G.9 nonessential hypothetical protein KEEP 3686901..3686911 3686901 3686911 I NA NA IG3357_Rv3300c-Rv3301c KEEP 3686912..3687577 3686912 3687577 - 221 15610437 phoY1 Rv3301c COG0704P III.A.4 nonessential phosphate transporter PhoU KEEP 3687578..3687684 3687578 3687684 I NA NA IG3358_Rv3301c-Rv3302c KEEP 3687685..3689442 3687685 3689442 - 585 15610438 glpD2 Rv3302c COG0578C I.B.6a nonessential glycerol-3-phosphate dehydrogenase KEEP 3689443..3689456 3689443 3689456 I NA NA IG3359_Rv3302c-Rv3303c KEEP 3689457..3690938 3689457 3690938 - 493 15610439 lpdA Rv3303c COG1249C I.B.2 nonessential flavoprotein disulfide reductase KEEP 3690939..3691140 3690939 3690943 I NA NA IG3360_Rv3303c-Rv3304 KEEP 3690939..3691140 3690944 3691077 I NA NA IG3360_Rv3303c-Rv3304 Marin et al 2022 + homoplasy analysis DISCARD 3690939..3691140 3691078 3691140 I NA NA IG3360_Rv3303c-Rv3304 KEEP 3691141..3691620 3691141 3691620 + 159 15610440 - Rv3304 - V nonessential hypothetical protein KEEP 3691621..3691638 3691621 3691638 I NA NA IG3361_Rv3304-Rv3305c KEEP 3691639..3692808 3691639 3692808 - 389 57117086 amiA1 Rv3305c COG1473R II.B.3 nonessential N-acyl-L-amino acid amidohydrolase KEEP 3692805..3693989 3692805 3693989 - 394 57117087 amiB1 Rv3306c COG1473R II.B.3 nonessential amidohydrolase AmiB1 KEEP 3693990..3694053 3693990 3694053 I NA NA IG3363_Rv3306c-Rv3307 KEEP 3694054..3694860 3694054 3694860 + 268 15610443 deoD Rv3307 COG0005F I.F.4 nonessential purine nucleoside phosphorylase KEEP 3694861..3694863 3694861 3694863 I NA NA IG3364_Rv3307-Rv3308 KEEP 3694864..3696468 3694864 3696468 + 534 15610444 pmmB Rv3308 COG1109G I.A.1 nonessential phosphomannomutase KEEP 3696470..3697093 3696470 3697093 - 207 15610445 upp Rv3309c COG0035F I.F.4 nonessential uracil phosphoribosyltransferase KEEP 3697094..3697197 3697094 3697197 I NA NA IG3366_Rv3309c-Rv3310 KEEP 3697198..3698097 3697198 3698097 + 299 15610446 - Rv3310 - IV.I nonessential acid phosphatase KEEP 3698098..3698120 3698098 3698120 I NA NA IG3367_Rv3310-Rv3311 KEEP 3698121..3699383 3698121 3699383 + 420 15610447 - Rv3311 - V nonessential hypothetical protein KEEP 3699384..3699403 3699384 3699403 I NA NA IG3368_Rv3311-Rv3312c KEEP 3699404..3700330 3699404 3700330 - 308 15610448 - Rv3312c COG0596R VI nonessential hypothetical protein KEEP 3700331..3700704 3700331 3700704 I NA NA IG3369_Rv3312c-Rv3312A KEEP 3700705..3701016 3700705 3701016 - 103 57117088 - Rv3312A - V nonessential secreted protein antigen KEEP 3701017..3701086 3701017 3701086 I NA NA IG3370_Rv3312A-Rv3313c KEEP 3701087..3702184 3701087 3702184 - 365 15610449 add Rv3313c COG1816F I.F.4 nonessential adenosine deaminase KEEP 3702184..3703467 3702184 3703467 - 427 15610450 deoA Rv3314c COG0213F I.F.4 nonessential thymidine phosphorylase KEEP 3703464..3703865 3703464 3703865 - 133 15610451 cdd Rv3315c COG0295F I.F.4 nonessential cytidine deaminase KEEP 3703866..3704101 3703866 3704101 I NA NA IG3373_Rv3315c-Rv3316 KEEP 3704102..3704440 3704102 3704440 + 112 15610452 sdhC Rv3316 COG2009C I.B.3 nonessential succinate dehydrogenase cytochrome B-556 subunit KEEP 3704437..3704871 3704437 3704871 + 144 15610453 sdhD Rv3317 COG2142C I.B.3 nonessential succinate dehydrogenase hydrophobic membrane anchor subunit SdhD KEEP 3704872..3704999 3704872 3704902 I NA NA IG3375_Rv3317-Rv3318 KEEP 3704872..3704999 3704903 3704991 I NA NA IG3375_Rv3317-Rv3318 Marin et al 2022 + homoplasy analysis DISCARD 3704872..3704999 3704992 3704999 I NA NA IG3375_Rv3317-Rv3318 KEEP 3705000..3706772 3705000 3706772 + 590 15610454 sdhA Rv3318 COG1053C I.B.3 nonessential succinate dehydrogenase flavoprotein subunit KEEP 3706772..3707563 3706772 3707563 + 263 15610455 sdhB Rv3319 COG0479C I.B.3 nonessential succinate dehydrogenase iron-sulfur subunit KEEP 3707564..3707641 3707564 3707576 I NA NA IG3377_Rv3319-Rv3320c KEEP 3707564..3707641 3707577 3707634 I NA NA IG3377_Rv3319-Rv3320c Only Marin et al 2022 KEEP 3707564..3707641 3707635 3707641 I NA NA IG3377_Rv3319-Rv3320c KEEP 3707642..3708070 3707642 3708070 - 142 15610456 - Rv3320c COG1848R V nonessential hypothetical protein KEEP 3708071..3708073 3708071 3708073 I NA NA IG3378_Rv3320c-Rv3321c KEEP 3708074..3708316 3708074 3708316 - 80 15610457 - Rv3321c - V nonessential hypothetical protein KEEP 3708317..3708437 3708317 3708437 I NA NA IG3379_Rv3321c-Rv3322c KEEP 3708438..3709052 3708438 3709052 - 204 57117089 - Rv3322c COG0500QR I.G.4 nonessential methyltransferase KEEP 3709049..3709714 3709049 3709714 - 221 57117090 moaX Rv3323c COG0314H,COG1977H I.B.4 nonessential MOAD-MOAE fusion protein MOAX KEEP 3709715..3710269 3709715 3710269 - 184 161352462 moaC Rv3324c COG0315H VII nonessential molybdenum cofactor biosynthesis protein C KEEP 3710270..3710432 3710270 3710373 I NA NA IG3382_Rv3324c-Rv3325 KEEP 3710270..3710432 3710374 3710432 I NA NA IG3382_Rv3324c-Rv3325 Annotation + Marin et al 2022 DISCARD 3710433..3710759 3710433 3710759 + 108 15610461 - Rv3325 COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3710756..3711694 3710756 3711694 + 312 15610462 - Rv3326 COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3711695..3711748 3711695 3711748 I NA NA IG3384_Rv3326-Rv3327 repeat Annotation + Marin et al 2022 DISCARD 3711749..3713461 3711749 3712827 + 570 15610463 - Rv3327 COG2128S,COG3547L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3711749..3713461 3712828 3713461 + 570 15610463 - Rv3327 COG2128S,COG3547L IV.B.1 phage nonessential transposase KEEP 3713394..3714332 3713394 3714332 - 312 15610464 sigJ Rv3328c COG1595K II.A.7 nonessential RNA polymerase sigma factor SigJ KEEP 3714333..3714391 3714333 3714391 I NA NA IG3386_Rv3328c-Rv3329 KEEP 3714392..3715708 3714392 3715708 + 438 15610465 - Rv3329 COG0161H IV.H nonessential hypothetical protein KEEP 3715709..3715776 3715709 3715776 I NA NA IG3387_Rv3329-Rv3330 KEEP 3715777..3716994 3715777 3716994 + 405 15610466 dacB1 Rv3330 COG1686M II.C.3 nonessential penicillin-binding protein DacB1 KEEP 3716995..3717089 3716995 3717089 I NA NA IG3388_Rv3330-Rv3331 KEEP 3717090..3718598 3717090 3718598 + 502 15610467 sugI Rv3331 COG0477GEPR III.A.3 nonessential sugar-transport integral membrane protein SugI KEEP 3718595..3719746 3718595 3719746 + 383 15610468 nagA Rv3332 COG1820G II.C.3 essential N-acetylglucosamine-6-phosphate deacetylase KEEP 3719747..3719936 3719747 3719936 I NA NA IG3390_Rv3332-Rv3333c KEEP 3719937..3720782 3719937 3720782 - 281 15610469 - Rv3333c - VI nonessential hypothetical protein KEEP 3720783..3721256 3720783 3721256 I NA NA IG3391_Rv3333c-Rv3334 KEEP 3721257..3721697 3721257 3721697 + 146 15610470 - Rv3334 COG0789K I.J.1 nonessential MerR family transcriptional regulator KEEP 3721698..3721730 3721698 3721730 I NA NA IG3392_Rv3334-Rv3335c KEEP 3721731..3722600 3721731 3722600 - 289 15610471 - Rv3335c COG1295S II.C.5 essential integral membrane protein KEEP 3722601..3722620 3722601 3722620 I NA NA IG3393_Rv3335c-Rv3336c KEEP 3722621..3723631 3722621 3723631 - 336 15610472 trpS Rv3336c COG0180J II.A.3 essential tryptophanyl-tRNA synthetase KEEP 3723632..3723655 3723632 3723655 I NA NA IG3394_Rv3336c-Rv3337 KEEP 3723656..3724042 3723656 3724042 + 128 57117091 - Rv3337 COG0596R V nonessential hypothetical protein KEEP 3723904..3724548 3723904 3724548 + 214 15610474 - Rv3338 COG0596R V nonessential hypothetical protein KEEP 3724549..3724614 3724549 3724614 I NA NA IG3396_Rv3338-Rv3339c Only Marin et al 2022 KEEP 3724615..3725844 3724615 3724618 - 409 15610475 icd1 Rv3339c COG0538C I.B.3 nonessential isocitrate dehydrogenase Only Marin et al 2022 KEEP 3724615..3725844 3724619 3725844 - 409 15610475 icd1 Rv3339c COG0538C I.B.3 nonessential isocitrate dehydrogenase KEEP 3725845..3726126 3725845 3726126 I NA NA IG3397_Rv3339c-Rv3340 KEEP 3726127..3727476 3726127 3727476 + 449 15610476 metC Rv3340 COG2873E I.D.2 nonessential O-acetylhomoserine aminocarboxypropyltransferase KEEP 3727477..3727487 3727477 3727487 I NA NA IG3398_Rv3340-Rv3341 KEEP 3727488..3728627 3727488 3728627 + 379 15610477 metX Rv3341 COG2021E I.D.2 essential homoserine O-acetyltransferase KEEP 3728624..3729355 3728624 3729355 + 243 15610478 - Rv3342 COG0500QR IV.H nonessential methyltransferase (methylase) KEEP 3729356..3729363 3729356 3729363 I NA NA IG3400_Rv3342-Rv3343c KEEP 3729364..3736935 3729364 3729447 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3729364..3736935 3729448 3729597 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3729364..3736935 3729598 3729625 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3729364..3736935 3729626 3729676 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3729364..3736935 3729677 3730344 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3729364..3736935 3730345 3732799 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3729364..3736935 3732800 3734470 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3729364..3736935 3734471 3734529 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3729364..3736935 3734530 3735633 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3729364..3736935 3735634 3736288 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3729364..3736935 3736289 3736500 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3729364..3736935 3736501 3736555 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3729364..3736935 3736556 3736692 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3729364..3736935 3736693 3736747 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein Annotation + Marin et al 2022 DISCARD 3729364..3736935 3736748 3736935 - 2523 57117092 PPE54 Rv3343c - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 3736936..3736983 3736936 3736983 I NA NA IG3401_Rv3343c-Rv3344c repeat KEEP 3736984..3738438 3736984 3737091 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3736984..3738438 3737092 3737207 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3736984..3738438 3737208 3737267 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3736984..3738438 3737268 3737497 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3736984..3738438 3737498 3737803 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3736984..3738438 3737804 3737808 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3736984..3738438 3737809 3737813 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3736984..3738438 3737814 3737818 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3736984..3738438 3737819 3737827 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3736984..3738438 3737828 3737836 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3736984..3738438 3737837 3737991 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3736984..3738438 3737992 3738438 - 484 57117093 PE_PGRS49 Rv3344c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3738158 3738961 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3738962 3738976 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3738977 3738985 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3738986 3739051 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3739052 3739056 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3739057 3739130 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3739131 3739133 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3739134 3739158 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3739159 3739163 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3739164 3739193 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3739194 3739202 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3739203 3739206 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3739207 3739899 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3739900 3739959 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + homoplasy analysis DISCARD 3738158..3742774 3739960 3740010 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740011 3740064 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740065 3740131 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740132 3740137 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740138 3740140 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740141 3740160 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740161 3740208 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740209 3740213 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740214 3740229 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740230 3740301 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740302 3740322 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740323 3740337 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740338 3740574 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740575 3740591 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740592 3740604 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740605 3740616 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740617 3740620 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740621 3740629 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740630 3740632 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740633 3740643 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740644 3740655 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740656 3740658 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740659 3740666 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740667 3740680 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740681 3740698 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740699 3740701 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3740702 3740939 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3740940 3741171 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3741172 3741178 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3741179 3741285 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3741286 3741394 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3741395 3741501 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3741502 3741604 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3741605 3741623 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3741624 3741678 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3741679 3741680 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3741681 3741914 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3741915 3741941 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3741942 3742247 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3742248 3742249 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3742250 3742256 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3742257 3742315 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3738158..3742774 3742316 3742371 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3738158..3742774 3742372 3742774 - 1538 57117094 PE_PGRS50 Rv3345c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3742775..3743197 3742775 3743197 I NA NA IG3403_Rv3345c-Rv3346c KEEP 3743198..3743455 3743198 3743210 - 85 15610482 - Rv3346c - V nonessential hypothetical protein KEEP 3743198..3743455 3743211 3743455 - 85 15610482 - Rv3346c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3743456..3743710 3743456 3743502 I NA NA IG3404_Rv3346c-Rv3347c Annotation + Marin et al 2022 DISCARD 3743456..3743710 3743503 3743506 I NA NA IG3404_Rv3346c-Rv3347c KEEP 3743456..3743710 3743507 3743603 I NA NA IG3404_Rv3346c-Rv3347c Annotation + Marin et al 2022 DISCARD 3743456..3743710 3743604 3743709 I NA NA IG3404_Rv3346c-Rv3347c Annotation + homoplasy analysis DISCARD 3743456..3743710 3743710 3743710 I NA NA IG3404_Rv3346c-Rv3347c Annotation + Marin et al 2022 DISCARD 3743711..3753184 3743711 3753184 - 3157 57117095 PPE55 Rv3347c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3753185..3753764 3753185 3753325 I NA NA IG3405_Rv3347c-Rv3348 repeat KEEP 3753185..3753764 3753326 3753764 I NA NA IG3405_Rv3347c-Rv3348 repeat Annotation + Marin et al 2022 DISCARD 3753765..3754256 3753765 3754256 + 163 15610484 - Rv3348 - IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3754257..3754292 3754257 3754292 I NA NA IG3406_Rv3348-Rv3349c repeat Annotation + Marin et al 2022 DISCARD 3754293..3755033 3754293 3754368 - 246 15610485 - Rv3349c COG3464L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3754293..3755033 3754369 3755033 - 246 15610485 - Rv3349c COG3464L IV.B.1 phage nonessential transposase KEEP 3755034..3755951 3755034 3755951 I NA NA IG3407_Rv3349c-Rv3350c repeat KEEP 3755952..3767102 3755952 3756035 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3756036 3756185 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3756186 3756409 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3756410 3756480 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3756481 3756940 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3756941 3757478 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3757479 3757569 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3757570 3757629 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3757630 3757772 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3757773 3757828 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3757829 3757878 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3757879 3758040 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3758041 3758116 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3758117 3758193 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3758194 3758715 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3758716 3759099 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3759100 3759106 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3759107 3759186 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3759187 3759330 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3759331 3759390 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3759391 3759533 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3759534 3759589 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3759590 3759678 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3759679 3759738 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3759739 3759825 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3759826 3759909 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3759910 3760355 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3760356 3760409 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3760410 3760416 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3760417 3760675 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3760676 3760752 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3760753 3760985 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3760986 3762383 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3762384 3762655 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3762656 3762660 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3762661 3762818 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3762819 3763047 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3763048 3763101 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3763102 3763222 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3763223 3763275 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3763276 3763281 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3763282 3763332 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3763333 3764058 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3764059 3764114 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3764115 3764133 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3764134 3764237 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3764238 3764250 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3764251 3764523 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3764524 3764808 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3764809 3764862 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3764863 3764979 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3764980 3765076 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3765077 3765160 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3765161 3765219 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3765220 3765797 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3765798 3765987 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3765988 3766017 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3766018 3766179 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3766180 3766214 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3766215 3766396 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3766397 3766434 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3766435 3766518 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3766519 3766551 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3766552 3766722 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3766723 3766759 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3766760 3766819 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3766820 3766828 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3755952..3767102 3766829 3767099 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3755952..3767102 3767100 3767102 - 3716 57117096 PPE56 Rv3350c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3767103..3767345 3767103 3767345 I NA NA IG3408_Rv3350c-Rv3351c KEEP 3767346..3768140 3767346 3768140 - 264 15610487 - Rv3351c COG0277C V nonessential hypothetical protein KEEP 3768141..3768221 3768141 3768221 I NA NA IG3409_Rv3351c-Rv3352c KEEP 3768222..3768593 3768222 3768593 - 123 15610488 - Rv3352c COG0277C I.B.7 nonessential oxidoreductase KEEP 3768594..3768735 3768594 3768735 I NA NA IG3410_Rv3352c-Rv3353c KEEP 3768736..3768996 3768736 3768996 - 86 57117097 - Rv3353c - V nonessential hypothetical protein KEEP 3768997..3769110 3768997 3769110 I NA NA IG3411_Rv3353c-Rv3354 KEEP 3769111..3769500 3769111 3769500 + 129 15610490 - Rv3354 - V nonessential hypothetical protein KEEP 3769501..3769513 3769501 3769513 I NA NA IG3412_Rv3354-Rv3355c KEEP 3769514..3769807 3769514 3769526 - 97 15610491 - Rv3355c - V nonessential hypothetical protein KEEP 3769514..3769807 3769527 3769724 - 97 15610491 - Rv3355c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3769514..3769807 3769725 3769748 - 97 15610491 - Rv3355c - V nonessential hypothetical protein KEEP 3769514..3769807 3769749 3769807 - 97 15610491 - Rv3355c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 3769804..3770649 3769804 3769854 - 281 15610492 folD Rv3356c COG0190H I.G.2 essential bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase Only Marin et al 2022 KEEP 3769804..3770649 3769855 3770649 - 281 15610492 folD Rv3356c COG0190H I.G.2 essential bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase KEEP 3770650..3770772 3770650 3770772 I NA NA IG3414_Rv3356c-Rv3357 KEEP 3770773..3771048 3770773 3770992 + 91 15610493 - Rv3357 COG2161D V nonessential hypothetical protein KEEP 3770773..3771048 3770993 3771048 + 91 15610493 - Rv3357 COG2161D V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 3771045..3771302 3771045 3771089 + 85 15610494 - Rv3358 COG4115S V nonessential hypothetical protein Only Marin et al 2022 KEEP 3771045..3771302 3771090 3771302 + 85 15610494 - Rv3358 COG4115S V nonessential hypothetical protein KEEP 3771303..3771343 3771303 3771343 I NA NA IG3416_Rv3358-Rv3359 KEEP 3771344..3772534 3771344 3772534 + 396 15610495 - Rv3359 COG1902C I.B.7 nonessential oxidoreductase KEEP 3772535..3772650 3772535 3772650 I NA NA IG3417_Rv3359-Rv3360 KEEP 3772651..3773019 3772651 3773019 + 122 15610496 - Rv3360 COG1716T V nonessential hypothetical protein KEEP 3773016..3773567 3773016 3773567 - 183 15610497 - Rv3361c COG1357S V nonessential hypothetical protein KEEP 3773568..3773573 3773568 3773573 I NA NA IG3419_Rv3361c-Rv3362c KEEP 3773574..3774155 3773574 3774155 - 193 15610498 - Rv3362c COG2229R VI nonessential ATP/GTP-binding protein KEEP 3774136..3774504 3774136 3774504 - 122 15610499 - Rv3363c - V nonessential hypothetical protein KEEP 3774482..3774874 3774482 3774874 - 130 15610500 - Rv3364c COG2018R V nonessential hypothetical protein KEEP 3774871..3777501 3774871 3777501 - 876 15610501 - Rv3365c COG0642T V nonessential hypothetical protein KEEP 3777502..3777736 3777502 3777736 I NA NA IG3423_Rv3365c-Rv3366 KEEP 3777737..3778201 3777737 3778201 + 154 15610502 spoU Rv3366 COG0219J II.A.7 nonessential tRNA/rRNA methylase SpoU KEEP 3778202..3778567 3778202 3778567 I NA NA IG3424_Rv3366-Rv3367 KEEP 3778568..3780334 3778568 3779544 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3778568..3780334 3779545 3779766 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3778568..3780334 3779767 3779808 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3778568..3780334 3779809 3779899 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3778568..3780334 3779900 3779935 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3778568..3780334 3779936 3779981 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3778568..3780334 3779982 3780155 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3778568..3780334 3780156 3780175 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3778568..3780334 3780176 3780334 + 588 57117098 PE_PGRS51 Rv3367 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3780335..3780979 3780335 3780979 - 214 15610504 - Rv3368c COG0778C I.B.7 nonessential oxidoreductase KEEP 3780978..3781412 3780978 3781412 + 144 15610505 - Rv3369 COG0259H V nonessential hypothetical protein KEEP 3781413..3781500 3781413 3781500 I NA NA IG3427_Rv3369-Rv3370c KEEP 3781501..3784776 3781501 3784776 - 1091 161352461 dnaE2 Rv3370c COG0587L II.A.5 nonessential error-prone DNA polymerase KEEP 3784777..3784931 3784777 3784931 I NA NA IG3428_Rv3370c-Rv3371 KEEP 3784932..3786272 3784932 3786272 + 446 15610507 - Rv3371 - V essential hypothetical protein KEEP 3786273..3786313 3786273 3786313 I NA NA IG3429_Rv3371-Rv3372 KEEP 3786314..3787489 3786314 3787489 + 391 15610508 otsB2 Rv3372 COG0637R,COG1877G III.E essential trehalose 6-phosphate phosphatase KEEP 3787490..3787725 3787490 3787725 I NA NA IG3430_Rv3372-Rv3373 KEEP 3787726..3788367 3787726 3788367 + 213 15610509 echA18 Rv3373 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 3788368..3788616 3788368 3788616 + 82 57117099 echA18.1 Rv3374 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 3788617..3788620 3788617 3788620 I NA NA IG3432_Rv3374-Rv3375 KEEP 3788621..3790048 3788621 3790048 + 475 15610511 amiD Rv3375 COG0154J VII essential amidase AmiD KEEP 3790049..3790155 3790049 3790155 I NA NA IG3433_Rv3375-Rv3376 KEEP 3790156..3790809 3790156 3790809 + 217 15610512 - Rv3376 COG1011R V nonessential hypothetical protein KEEP 3790810..3790847 3790810 3790847 I NA NA IG3434_Rv3376-Rv3377c KEEP 3790848..3792353 3790848 3792353 - 501 15610513 - Rv3377c - VI nonessential cyclase KEEP 3792354..3792357 3792354 3792357 I NA NA IG3435_Rv3377c-Rv3378c KEEP 3792358..3793248 3792358 3793248 - 296 15610514 - Rv3378c - VI nonessential hypothetical protein KEEP 3793249..3793256 3793249 3793256 I NA NA IG3436_Rv3378c-Rv3379c KEEP 3793257..3794867 3793257 3794867 - 536 15610515 dxs2 Rv3379c COG1154HI VII nonessential 1-deoxy-D-xylulose-5-phosphate synthase KEEP 3794868..3795099 3794868 3795099 I NA NA IG3437_Rv3379c-Rv3380c Annotation + Marin et al 2022 DISCARD 3795100..3795984 3795100 3795984 - 294 15610516 - Rv3380c COG2801L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3795985..3796034 3795985 3796034 I NA NA IG3438_Rv3380c-Rv3381c repeat Annotation + Marin et al 2022 DISCARD 3796035..3796361 3796035 3796361 - 108 15610517 - Rv3381c COG2963L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3796362..3796447 3796362 3796422 I NA NA IG3439_Rv3381c-Rv3382c Annotation + Marin et al 2022 DISCARD 3796362..3796447 3796423 3796447 I NA NA IG3439_Rv3381c-Rv3382c KEEP 3796448..3797437 3796448 3797437 - 329 57117100 lytB1 Rv3382c COG0761IM II.C.3 nonessential LYTB-like protein LYTB1 KEEP 3797437..3798489 3797437 3798489 - 350 15610519 idsB Rv3383c COG0142H I.G.11 nonessential polyprenyl synthetase IdsB KEEP 3798490..3799242 3798490 3799242 I NA NA IG3441_Rv3383c-Rv3384c KEEP 3799243..3799635 3799243 3799635 - 130 15610520 - Rv3384c - V nonessential hypothetical protein KEEP 3799635..3799943 3799635 3799943 - 102 15610521 - Rv3385c COG4118D V nonessential hypothetical protein KEEP 3799944..3800091 3799944 3800029 I NA NA IG3443_Rv3385c-Rv3386 KEEP 3799944..3800091 3800030 3800091 I NA NA IG3443_Rv3385c-Rv3386 Annotation + Marin et al 2022 DISCARD 3800092..3800796 3800092 3800120 + 234 15610522 - Rv3386 COG3039L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3800092..3800796 3800121 3800796 + 234 15610522 - Rv3386 COG3039L IV.B.1 phage nonessential transposase KEEP 3800786..3801463 3800786 3801463 + 225 15610523 - Rv3387 COG3039L IV.B.1 phage nonessential transposase KEEP 3801464..3801652 3801464 3801652 I NA NA IG3445_Rv3387-Rv3388 repeat KEEP 3801653..3803848 3801653 3801823 + 731 57117101 PE_PGRS52 Rv3388 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3801653..3803848 3801824 3801874 + 731 57117101 PE_PGRS52 Rv3388 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3801653..3803848 3801875 3802055 + 731 57117101 PE_PGRS52 Rv3388 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3801653..3803848 3802056 3802113 + 731 57117101 PE_PGRS52 Rv3388 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3801653..3803848 3802114 3802121 + 731 57117101 PE_PGRS52 Rv3388 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3801653..3803848 3802122 3803827 + 731 57117101 PE_PGRS52 Rv3388 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3801653..3803848 3803828 3803843 + 731 57117101 PE_PGRS52 Rv3388 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 3801653..3803848 3803844 3803848 + 731 57117101 PE_PGRS52 Rv3388 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3803849..3803918 3803849 3803918 I NA NA IG3446_Rv3388-Rv3389c Annotation + Marin et al 2022 DISCARD 3803919..3804791 3803919 3804791 - 290 15610525 - Rv3389c COG2030I VI nonessential dehydrogenase KEEP 3804792..3804864 3804792 3804864 I NA NA IG3447_Rv3389c-Rv3390 KEEP 3804865..3805575 3804865 3805575 + 236 15610526 lpqD Rv3390 COG0406G II.C.1 nonessential lipoprotein LpqD KEEP 3805576..3805620 3805576 3805620 I NA NA IG3448_Rv3390-Rv3391 KEEP 3805621..3807573 3805621 3807573 + 650 15610527 acrA1 Rv3391 COG1028IQR,COG3320Q I.H.2 nonessential short chain dehydrogenase KEEP 3807574..3808437 3807574 3808261 - 287 15610528 cmaA1 Rv3392c COG2230M I.H.2 nonessential cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) KEEP 3807574..3808437 3808262 3808421 - 287 15610528 cmaA1 Rv3392c COG2230M I.H.2 nonessential cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) Only Marin et al 2022 KEEP 3807574..3808437 3808422 3808437 - 287 15610528 cmaA1 Rv3392c COG2230M I.H.2 nonessential cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) KEEP 3808438..3808460 3808438 3808460 I NA NA IG3450_Rv3392c-Rv3393 KEEP 3808461..3809387 3808461 3809387 + 308 15610529 iunH Rv3393 COG1957F I.F.4 nonessential nucleoside hydrolase IunH KEEP 3809388..3809441 3809388 3809441 I NA NA IG3451_Rv3393-Rv3394c KEEP 3809442..3811025 3809442 3811025 - 527 15610530 - Rv3394c COG0389L V nonessential hypothetical protein KEEP 3811022..3811636 3811022 3811636 - 204 57117102 - Rv3395c - II.C.5 nonessential hypothetical protein KEEP 3811637..3811718 3811637 3811718 I NA NA IG3453_Rv3395c-Rv3395A KEEP 3811719..3812345 3811719 3812345 + 208 57117103 - Rv3395A - V nonessential hypothetical protein KEEP 3812346..3812500 3812346 3812500 I NA NA IG3454_Rv3395A-Rv3396c KEEP 3812501..3814078 3812501 3814078 - 525 15610532 guaA Rv3396c COG0518F,COG0519F I.F.1 essential bifunctional GMP synthase/glutamine amidotransferase protein KEEP 3814079..3814089 3814079 3814089 I NA NA IG3455_Rv3396c-Rv3397c KEEP 3814090..3814998 3814090 3814998 - 302 15610533 phyA Rv3397c COG1562I I.G.11 nonessential phytoene synthase KEEP 3814999..3815026 3814999 3815026 I NA NA IG3456_Rv3397c-Rv3398c KEEP 3815027..3816106 3815027 3816106 - 359 57117104 idsA1 Rv3398c COG0142H I.G.11 essential multifunctional dimethylallyltransferase/farnesyl diphosphate synthetase/ farnesyltranstransferase KEEP 3816107..3816128 3816107 3816128 I NA NA IG3457_Rv3398c-Rv3399 KEEP 3816129..3817175 3816129 3817175 + 348 15610535 - Rv3399 COG3315Q V nonessential hypothetical protein KEEP 3817176..3817238 3817176 3817238 I NA NA IG3458_Rv3399-Rv3400 KEEP 3817239..3818027 3817239 3818027 + 262 15610536 - Rv3400 COG0637R I.C.3 essential hydrolase KEEP 3818028..3818041 3818028 3818041 I NA NA IG3459_Rv3400-Rv3401 KEEP 3818042..3820402 3818042 3820386 + 786 15610537 - Rv3401 COG1554G V nonessential hypothetical protein KEEP 3818042..3820402 3820387 3820402 + 786 15610537 - Rv3401 COG1554G V nonessential hypothetical protein Only Marin et al 2022 KEEP 3820403..3820652 3820403 3820598 I NA NA IG3460_Rv3401-Rv3402c Marin et al 2022 + homoplasy analysis DISCARD 3820403..3820652 3820599 3820652 I NA NA IG3460_Rv3401-Rv3402c KEEP 3820653..3821891 3820653 3820710 - 412 15610538 - Rv3402c COG0399M V nonessential hypothetical protein KEEP 3820653..3821891 3820711 3820772 - 412 15610538 - Rv3402c COG0399M V nonessential hypothetical protein Only Marin et al 2022 KEEP 3820653..3821891 3820773 3821891 - 412 15610538 - Rv3402c COG0399M V nonessential hypothetical protein KEEP 3821892..3822261 3821892 3822261 I NA NA IG3461_Rv3402c-Rv3403c KEEP 3822262..3823863 3822262 3823863 - 533 15610539 - Rv3403c COG4529S VI nonessential hypothetical protein KEEP 3823864..3823879 3823864 3823879 I NA NA IG3462_Rv3403c-Rv3404c KEEP 3823880..3824584 3823880 3824584 - 234 15610540 - Rv3404c COG0223J V nonessential hypothetical protein KEEP 3824585..3824701 3824585 3824701 I NA NA IG3463_Rv3404c-Rv3405c KEEP 3824702..3825268 3824702 3825268 - 188 15610541 - Rv3405c COG1309K I.J.1 nonessential transcriptional regulatory protein KEEP 3825269..3825329 3825269 3825329 I NA NA IG3464_Rv3405c-Rv3406 KEEP 3825330..3826217 3825330 3826217 + 295 15610542 - Rv3406 COG2175Q VI nonessential dioxygenase KEEP 3826218..3826251 3826218 3826251 I NA NA IG3465_Rv3406-Rv3407 KEEP 3826252..3826551 3826252 3826551 + 99 15610543 - Rv3407 COG4118D V nonessential hypothetical protein KEEP 3826548..3826958 3826548 3826958 + 136 15610544 - Rv3408 COG1848R V nonessential hypothetical protein KEEP 3826959..3826990 3826959 3826990 I NA NA IG3467_Rv3408-Rv3409c KEEP 3826991..3828727 3826991 3828727 - 578 15610545 choD Rv3409c COG2303E I.A.3 nonessential cholesterol oxidase precursor KEEP 3828728..3828782 3828728 3828782 I NA NA IG3468_Rv3409c-Rv3410c KEEP 3828783..3829910 3828783 3829910 - 375 15610546 guaB3 Rv3410c COG0516F I.F.1 nonessential inositol-5-monophosphate dehydrogenase KEEP 3829911..3829929 3829911 3829929 I NA NA IG3469_Rv3410c-Rv3411c KEEP 3829930..3831519 3829930 3831519 - 529 15610547 guaB2 Rv3411c COG0516F,COG0517R I.F.1 essential inositol-5-monophosphate dehydrogenase KEEP 3831520..3831725 3831520 3831725 I NA NA IG3470_Rv3411c-Rv3412 KEEP 3831726..3832136 3831726 3832136 + 136 15610548 - Rv3412 - V nonessential hypothetical protein KEEP 3832137..3832145 3832137 3832145 I NA NA IG3471_Rv3412-Rv3413c KEEP 3832146..3833045 3832146 3833045 - 299 15610549 - Rv3413c - VI nonessential hypothetical protein KEEP 3833038..3833676 3833038 3833676 - 212 15610550 sigD Rv3414c COG1595K II.A.7 nonessential RNA polymerase sigma factor SigD KEEP 3833677..3833693 3833677 3833693 I NA NA IG3473_Rv3414c-Rv3415c KEEP 3833694..3834521 3833694 3834521 - 275 15610551 - Rv3415c - V nonessential hypothetical protein KEEP 3834522..3834891 3834522 3834891 I NA NA IG3474_Rv3415c-Rv3416 KEEP 3834892..3835200 3834892 3835200 + 102 15610552 whiB3 Rv3416 - I.J.1 nonessential transcriptional regulatory protein WHIB-like WHIB3 KEEP 3835201..3835271 3835201 3835201 I NA NA IG3475_Rv3416-Rv3417c KEEP 3835201..3835271 3835202 3835264 I NA NA IG3475_Rv3416-Rv3417c Marin et al 2022 + homoplasy analysis DISCARD 3835201..3835271 3835265 3835271 I NA NA IG3475_Rv3416-Rv3417c KEEP 3835272..3836891 3835272 3836891 - 539 15610553 groEL Rv3417c COG0459O III.B essential chaperonin GroEL KEEP 3836892..3836985 3836892 3836985 I NA NA IG3476_Rv3417c-Rv3418c KEEP 3836986..3837288 3836986 3837288 - 100 15610554 groES Rv3418c COG0234O III.B essential co-chaperonin GroES KEEP 3837289..3837554 3837289 3837554 I NA NA IG3477_Rv3418c-Rv3419c KEEP 3837555..3838589 3837555 3838589 - 344 15610555 gcp Rv3419c COG0533O II.B.3 essential O-sialoglycoprotein endopeptidase KEEP 3838586..3839062 3838586 3839062 - 158 15610556 rimI Rv3420c COG0456R II.A.1 nonessential ribosomal-protein-alanine acetyltransferase KEEP 3839059..3839694 3839059 3839694 - 211 15610557 - Rv3421c COG1214O V nonessential hypothetical protein KEEP 3839691..3840197 3839691 3840197 - 168 15610558 - Rv3422c COG0802R V essential hypothetical protein KEEP 3840194..3841420 3840194 3841420 - 408 15610559 alr Rv3423c COG0787M I.D.6 essential alanine racemase KEEP 3841421..3841713 3841421 3841618 I NA NA IG3482_Rv3423c-Rv3424c KEEP 3841421..3841713 3841619 3841713 I NA NA IG3482_Rv3423c-Rv3424c Marin et al 2022 + homoplasy analysis DISCARD 3841714..3842076 3841714 3842076 - 120 15610560 - Rv3424c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 3842077..3842238 3842077 3842238 I NA NA IG3483_Rv3424c-Rv3425 Annotation + Marin et al 2022 DISCARD 3842239..3842769 3842239 3842454 + 176 57117105 PPE57 Rv3425 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3842239..3842769 3842455 3842470 + 176 57117105 PPE57 Rv3425 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + homoplasy analysis DISCARD 3842239..3842769 3842471 3842551 + 176 57117105 PPE57 Rv3425 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3842239..3842769 3842552 3842559 + 176 57117105 PPE57 Rv3425 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3842239..3842769 3842560 3842670 + 176 57117105 PPE57 Rv3425 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3842239..3842769 3842671 3842724 + 176 57117105 PPE57 Rv3425 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + homoplasy analysis DISCARD 3842239..3842769 3842725 3842769 + 176 57117105 PPE57 Rv3425 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3842770..3843035 3842770 3842907 I NA NA IG3484_Rv3425-Rv3426 repeat Annotation + Marin et al 2022 DISCARD 3842770..3843035 3842908 3842978 I NA NA IG3484_Rv3425-Rv3426 repeat KEEP 3842770..3843035 3842979 3843035 I NA NA IG3484_Rv3425-Rv3426 repeat Annotation + Marin et al 2022 DISCARD 3843036..3843734 3843036 3843117 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3843036..3843734 3843118 3843181 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3843036..3843734 3843182 3843275 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3843036..3843734 3843276 3843316 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3843036..3843734 3843317 3843468 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3843036..3843734 3843469 3843518 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3843036..3843734 3843519 3843520 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3843036..3843734 3843521 3843522 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3843036..3843734 3843523 3843705 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3843036..3843734 3843706 3843712 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3843036..3843734 3843713 3843714 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3843036..3843734 3843715 3843734 + 232 57117106 PPE58 Rv3426 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3843735..3843884 3843735 3843747 I NA NA IG3485_Rv3426-Rv3427c repeat KEEP 3843735..3843884 3843748 3843753 I NA NA IG3485_Rv3426-Rv3427c repeat Annotation + Marin et al 2022 DISCARD 3843735..3843884 3843754 3843758 I NA NA IG3485_Rv3426-Rv3427c repeat KEEP 3843735..3843884 3843759 3843760 I NA NA IG3485_Rv3426-Rv3427c repeat Annotation + Marin et al 2022 DISCARD 3843735..3843884 3843761 3843884 I NA NA IG3485_Rv3426-Rv3427c repeat KEEP 3843885..3844640 3843885 3844640 - 251 15610563 - Rv3427c COG1484L IV.B.1 phage essential transposase KEEP 3844641..3844737 3844641 3844680 I NA NA IG3486_Rv3427c-Rv3428c repeat KEEP 3844641..3844737 3844681 3844737 I NA NA IG3486_Rv3427c-Rv3428c repeat Annotation + Marin et al 2022 DISCARD 3844738..3845970 3844738 3844756 - 410 15610564 - Rv3428c COG4584L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3844738..3845970 3844757 3845969 - 410 15610564 - Rv3428c COG4584L IV.B.1 phage nonessential transposase KEEP 3844738..3845970 3845970 3845970 - 410 15610564 - Rv3428c COG4584L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 3845971..3847164 3845971 3847164 I NA NA IG3487_Rv3428c-Rv3429 repeat Annotation + Marin et al 2022 DISCARD 3847165..3847701 3847165 3847246 + 178 57117107 PPE59 Rv3429 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3847165..3847701 3847247 3847304 + 178 57117107 PPE59 Rv3429 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3847165..3847701 3847305 3847404 + 178 57117107 PPE59 Rv3429 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3847165..3847701 3847405 3847445 + 178 57117107 PPE59 Rv3429 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3847165..3847701 3847446 3847581 + 178 57117107 PPE59 Rv3429 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3847165..3847701 3847582 3847699 + 178 57117107 PPE59 Rv3429 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3847165..3847701 3847700 3847701 + 178 57117107 PPE59 Rv3429 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3847642..3848805 3847642 3847699 - 387 15610566 - Rv3430c COG2801L IV.B.1 nonessential transposase KEEP 3847642..3848805 3847700 3847711 - 387 15610566 - Rv3430c COG2801L IV.B.1 nonessential transposase Only Marin et al 2022 KEEP 3847642..3848805 3847712 3847713 - 387 15610566 - Rv3430c COG2801L IV.B.1 nonessential transposase KEEP 3847642..3848805 3847714 3847896 - 387 15610566 - Rv3430c COG2801L IV.B.1 nonessential transposase Only Marin et al 2022 KEEP 3847642..3848805 3847897 3848805 - 387 15610566 - Rv3430c COG2801L IV.B.1 nonessential transposase KEEP 3848806..3849293 3848806 3849293 I NA NA IG3489_Rv3430c-Rv3431c KEEP 3849294..3850139 3849294 3850139 - 281 15610567 - Rv3431c COG3328L IV.B.1 nonessential hypothetical protein KEEP 3850140..3850371 3850140 3850371 I NA NA IG3490_Rv3431c-Rv3432c KEEP 3850372..3851754 3850372 3851754 - 460 15610568 gadB Rv3432c COG0076E I.C.1 nonessential glutamate decarboxylase GadB KEEP 3851755..3851791 3851755 3851791 I NA NA IG3491_Rv3432c-Rv3433c KEEP 3851792..3853213 3851792 3853213 - 473 15610569 - Rv3433c COG0062S,COG0063G V nonessential hypothetical protein KEEP 3853215..3853928 3853215 3853928 - 237 15610570 - Rv3434c - II.C.5 nonessential transmembrane protein KEEP 3853929..3853938 3853929 3853938 I NA NA IG3493_Rv3434c-Rv3435c KEEP 3853939..3854793 3853939 3854793 - 284 15610571 - Rv3435c - II.C.5 nonessential transmembrane protein KEEP 3854794..3855014 3854794 3855014 I NA NA IG3494_Rv3435c-Rv3436c KEEP 3855015..3856889 3855015 3856889 - 624 15610572 glmS Rv3436c COG0449M I.C.4 essential D-fructose-6-phosphate amidotransferase KEEP 3856890..3856910 3856890 3856910 I NA NA IG3495_Rv3436c-Rv3437 KEEP 3856911..3857387 3856911 3857387 + 158 15610573 - Rv3437 - II.C.5 nonessential transmembrane protein KEEP 3857388..3857396 3857388 3857396 I NA NA IG3496_Rv3437-Rv3438 KEEP 3857397..3858239 3857397 3858239 + 280 15610574 - Rv3438 - V nonessential hypothetical protein KEEP 3858240..3858258 3858240 3858258 I NA NA IG3497_Rv3438-Rv3439c KEEP 3858259..3859662 3858259 3859662 - 467 15610575 - Rv3439c - V nonessential hypothetical protein KEEP 3859663..3859664 3859663 3859664 I NA NA IG3498_Rv3439c-Rv3440c KEEP 3859665..3859976 3859665 3859976 - 103 15610576 - Rv3440c - VI nonessential hypothetical protein KEEP 3859977..3860023 3859977 3860023 I NA NA IG3499_Rv3440c-Rv3441c KEEP 3860024..3861370 3860024 3861370 - 448 15610577 mrsA Rv3441c COG1109G I.A.1 essential phospho-sugar mutase / MRSA protein KEEP 3861371..3861494 3861371 3861494 I NA NA IG3500_Rv3441c-Rv3442c KEEP 3861495..3861950 3861495 3861950 - 151 15610578 rpsI Rv3442c COG0103J II.A.1 nonessential 30S ribosomal protein S9 KEEP 3861947..3862390 3861947 3862390 - 147 15610579 rplM Rv3443c COG0102J II.A.1 essential 50S ribosomal protein L13 KEEP 3862391..3862623 3862391 3862569 I NA NA IG3502_Rv3443c-Rv3444c KEEP 3862391..3862623 3862570 3862578 I NA NA IG3502_Rv3443c-Rv3444c Only Marin et al 2022 KEEP 3862391..3862623 3862579 3862623 I NA NA IG3502_Rv3443c-Rv3444c KEEP 3862624..3862926 3862624 3862926 - 100 15610580 esxT Rv3444c COG4842S VI nonessential putative ESAT-6 like protein ESXT KEEP 3862927..3862946 3862927 3862946 I NA NA IG3503_Rv3444c-Rv3445c KEEP 3862947..3863324 3862947 3863324 - 125 15610581 esxU Rv3445c COG4842S VI nonessential ESAT-6 like protein ESXU KEEP 3863317..3864531 3863317 3864531 - 404 15610582 - Rv3446c - VI nonessential hypothetical protein KEEP 3864528..3868238 3864528 3868238 - 1236 15610583 - Rv3447c COG1674D II.C.4 nonessential hypothetical protein KEEP 3868239..3868351 3868239 3868351 I NA NA IG3506_Rv3447c-Rv3448 KEEP 3868352..3869755 3868352 3869755 + 467 15610584 - Rv3448 - II.C.5 nonessential integral membrane protein KEEP 3869752..3871119 3869752 3871119 + 455 15610585 mycP4 Rv3449 COG1404O II.C.2 nonessential membrane-anchored mycosin KEEP 3871084..3872496 3871084 3872496 - 470 15610586 - Rv3450c - II.C.4 nonessential hypothetical protein KEEP 3872497..3872616 3872497 3872616 I NA NA IG3509_Rv3450c-Rv3451 KEEP 3872617..3873405 3872617 3873405 + 262 57117108 cut3 Rv3451 - II.C.2 nonessential cutinase precursor CUT3 KEEP 3873406..3873451 3873406 3873451 I NA NA IG3510_Rv3451-Rv3452 KEEP 3873452..3874132 3873452 3873525 + 226 15610588 cut4 Rv3452 - II.C.2 nonessential cutinase precursor CUT4 KEEP 3873452..3874132 3873526 3873540 + 226 15610588 cut4 Rv3452 - II.C.2 nonessential cutinase precursor CUT4 Only Marin et al 2022 KEEP 3873452..3874132 3873541 3874132 + 226 15610588 cut4 Rv3452 - II.C.2 nonessential cutinase precursor CUT4 KEEP 3874133..3874403 3874133 3874403 I NA NA IG3511_Rv3452-Rv3453 KEEP 3874404..3874736 3874404 3874736 + 110 15610589 - Rv3453 - II.C.5 nonessential transmembrane protein KEEP 3874737..3874821 3874737 3874821 I NA NA IG3512_Rv3453-Rv3454 KEEP 3874822..3876090 3874822 3876090 + 422 15610590 - Rv3454 - III.A.1 nonessential integral membrane protein KEEP 3876052..3876945 3876052 3876945 - 297 161352460 truA Rv3455c COG0101J II.A.7 essential tRNA pseudouridine synthase A KEEP 3876890..3877432 3876890 3877432 - 180 15610592 rplQ Rv3456c COG0203J II.A.1 nonessential 50S ribosomal protein L17 KEEP 3877433..3877463 3877433 3877463 I NA NA IG3515_Rv3456c-Rv3457c KEEP 3877464..3878507 3877464 3878507 - 347 15610593 rpoA Rv3457c COG0202K II.A.7 essential DNA-directed RNA polymerase subunit alpha KEEP 3878508..3878658 3878508 3878560 I NA NA IG3516_Rv3457c-Rv3458c KEEP 3878508..3878658 3878561 3878637 I NA NA IG3516_Rv3457c-Rv3458c Only Marin et al 2022 KEEP 3878508..3878658 3878638 3878658 I NA NA IG3516_Rv3457c-Rv3458c KEEP 3878659..3879264 3878659 3879264 - 201 15610594 rpsD Rv3458c COG0522J II.A.1 essential 30S ribosomal protein S4 KEEP 3879265..3879272 3879265 3879272 I NA NA IG3517_Rv3458c-Rv3459c KEEP 3879273..3879692 3879273 3879692 - 139 15610595 rpsK Rv3459c COG0100J II.A.1 essential 30S ribosomal protein S11 KEEP 3879693..3879695 3879693 3879695 I NA NA IG3518_Rv3459c-Rv3460c KEEP 3879696..3880070 3879696 3880070 - 124 15610596 rpsM Rv3460c COG0099J II.A.1 nonessential 30S ribosomal protein S13 KEEP 3880071..3880285 3880071 3880285 I NA NA IG3519_Rv3460c-Rv3461c KEEP 3880286..3880399 3880286 3880399 - 37 15610597 rpmJ Rv3461c COG0257J II.A.1 nonessential 50S ribosomal protein L36 KEEP 3880400..3880431 3880400 3880431 I NA NA IG3520_Rv3461c-Rv3462c KEEP 3880432..3880653 3880432 3880653 - 73 15610598 infA Rv3462c COG0361J II.A.6 essential translation initiation factor IF-1 KEEP 3880654..3880906 3880654 3880906 I NA NA IG3521_Rv3462c-Rv3463 KEEP 3880907..3881764 3880907 3881764 + 285 15610599 - Rv3463 COG2141C II.B.4 nonessential hypothetical protein KEEP 3881765..3881836 3881765 3881836 I NA NA IG3522_Rv3463-Rv3464 KEEP 3881837..3882832 3881837 3882832 + 331 15610600 rmlB Rv3464 COG1088M I.C.3 essential dTDP-glucose 4,6-dehydratase RMLB KEEP 3882834..3883442 3882834 3883442 + 202 15610601 rmlC Rv3465 COG1898M I.C.3 essential dTDP-4-dehydrorhamnose 3,5-epimerase RmlC KEEP 3883443..3883524 3883443 3883524 I NA NA IG3524_Rv3465-Rv3466 KEEP 3883525..3884193 3883525 3883542 + 222 15610602 - Rv3466 - V repeat13E12 nonessential hypothetical protein KEEP 3883525..3884193 3883543 3884193 + 222 15610602 - Rv3466 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 3883964..3884917 3883964 3884917 + 317 15610603 - Rv3467 - V repeat13E12 nonessential hypothetical protein Annotation + Marin et al 2022 DISCARD 3884918..3884974 3884918 3884926 I NA NA IG3526_Rv3467-Rv3468c Annotation + Marin et al 2022 DISCARD 3884918..3884974 3884927 3884974 I NA NA IG3526_Rv3467-Rv3468c KEEP 3884975..3886069 3884975 3886069 - 364 57117109 - Rv3468c COG0451MG I.C.3 nonessential dTDP-glucose 4,6-dehydratase KEEP 3886070..3886072 3886070 3886072 I NA NA IG3527_Rv3468c-Rv3469c KEEP 3886073..3887083 3886073 3887083 - 336 15610605 mhpE Rv3469c COG0119E II.B.6 nonessential 4-hydroxy-2-ketovalerate aldolase KEEP 3887084..3887143 3887084 3887143 I NA NA IG3528_Rv3469c-Rv3470c KEEP 3887144..3888802 3887144 3888802 - 552 15610606 ilvB2 Rv3470c COG0028EH I.D.7 nonessential acetolactate synthase large subunit KEEP 3888803..3888807 3888803 3888807 I NA NA IG3529_Rv3470c-Rv3471c KEEP 3888808..3889341 3888808 3889341 - 177 15610607 - Rv3471c COG0662G V nonessential hypothetical protein KEEP 3889342..3889361 3889342 3889361 I NA NA IG3530_Rv3471c-Rv3472 KEEP 3889362..3889868 3889362 3889868 + 168 15610608 - Rv3472 - I.H.1 essential hypothetical protein KEEP 3889869..3889947 3889869 3889947 I NA NA IG3531_Rv3472-Rv3473c KEEP 3889948..3890733 3889948 3890733 - 261 15610609 bpoA Rv3473c COG0596R III.F nonessential peroxidase BpoA KEEP 3890734..3890829 3890734 3890770 I NA NA IG3532_Rv3473c-Rv3474 KEEP 3890734..3890829 3890771 3890829 I NA NA IG3532_Rv3473c-Rv3474 Annotation + Marin et al 2022 DISCARD 3890830..3891156 3890830 3891156 + 108 15610610 - Rv3474 COG2963L IV.B.1 phage nonessential transposase IS6110 Annotation + Marin et al 2022 DISCARD 3891051..3892091 3891051 3892091 + 346 15610611 - Rv3475 COG2801L IV.B.1 phage nonessential transposase IS6110 Annotation + Marin et al 2022 DISCARD 3892092..3892370 3892092 3892143 I NA NA IG3534_Rv3475-Rv3476c Annotation + Marin et al 2022 DISCARD 3892092..3892370 3892144 3892370 I NA NA IG3534_Rv3475-Rv3476c KEEP 3892371..3893720 3892371 3893720 - 449 15610612 kgtP Rv3476c COG0477GEPR III.A.3 nonessential dicarboxylic acid transport integral membrane protein KgtP KEEP 3893721..3894092 3893721 3894092 I NA NA IG3535_Rv3476c-Rv3477 KEEP 3894093..3894389 3894093 3894389 + 98 57117110 PE31 Rv3477 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 3894390..3894425 3894390 3894401 I NA NA IG3536_Rv3477-Rv3478 repeat KEEP 3894390..3894425 3894402 3894425 I NA NA IG3536_Rv3477-Rv3478 repeat Annotation + Marin et al 2022 DISCARD 3894426..3895607 3894426 3894790 + 393 57117111 PPE60 Rv3478 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 3894426..3895607 3894791 3894862 + 393 57117111 PPE60 Rv3478 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + homoplasy analysis DISCARD 3894426..3895607 3894863 3895078 + 393 57117111 PPE60 Rv3478 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 3894426..3895607 3895079 3895082 + 393 57117111 PPE60 Rv3478 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 3894426..3895607 3895083 3895137 + 393 57117111 PPE60 Rv3478 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 3894426..3895607 3895138 3895183 + 393 57117111 PPE60 Rv3478 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + homoplasy analysis DISCARD 3894426..3895607 3895184 3895525 + 393 57117111 PPE60 Rv3478 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 3894426..3895607 3895526 3895607 + 393 57117111 PPE60 Rv3478 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 3895608..3895819 3895608 3895819 I NA NA IG3537_Rv3478-Rv3479 KEEP 3895820..3898885 3895820 3898885 + 1021 57117112 - Rv3479 - II.C.5 nonessential hypothetical protein KEEP 3898886..3898908 3898886 3898908 I NA NA IG3538_Rv3479-Rv3480c KEEP 3898909..3900402 3898909 3900402 - 497 15610616 - Rv3480c COG1020Q V nonessential hypothetical protein KEEP 3900403..3900492 3900403 3900492 I NA NA IG3539_Rv3480c-Rv3481c KEEP 3900493..3901182 3900493 3901182 - 229 15610617 - Rv3481c - II.C.5 nonessential integral membrane protein KEEP 3901183..3901323 3901183 3901323 I NA NA IG3540_Rv3481c-Rv3482c KEEP 3901324..3902106 3901324 3902106 - 260 15610618 - Rv3482c - II.C.4 nonessential hypothetical protein KEEP 3902107..3902149 3902107 3902149 I NA NA IG3541_Rv3482c-Rv3483c KEEP 3902150..3902812 3902150 3902812 - 220 15610619 - Rv3483c - V nonessential hypothetical protein KEEP 3902813..3903077 3902813 3903077 I NA NA IG3542_Rv3483c-Rv3484 KEEP 3903078..3904616 3903078 3904616 + 512 15610620 cpsA Rv3484 COG1316K VII essential hypothetical protein KEEP 3904617..3904621 3904617 3904621 I NA NA IG3543_Rv3484-Rv3485c KEEP 3904622..3905566 3904622 3905566 - 314 15610621 - Rv3485c COG1028IQR VI nonessential short chain dehydrogenase KEEP 3905567..3905771 3905567 3905771 I NA NA IG3544_Rv3485c-Rv3486 KEEP 3905772..3906221 3905772 3906221 + 149 15610622 - Rv3486 COG2259S V nonessential hypothetical protein KEEP 3906174..3907007 3906174 3907007 - 277 15610623 lipF Rv3487c COG0657I II.B.5 nonessential esterase/lipase LipF KEEP 3907008..3907666 3907008 3907666 I NA NA IG3546_Rv3487c-Rv3488 KEEP 3907667..3907990 3907667 3907990 + 107 15610624 - Rv3488 COG1695K V nonessential hypothetical protein KEEP 3907991..3908071 3907991 3908071 I NA NA IG3547_Rv3488-Rv3489 KEEP 3908072..3908236 3908072 3908236 + 54 15610625 - Rv3489 - VI essential hypothetical protein KEEP 3908236..3909738 3908236 3909738 + 500 15610626 otsA Rv3490 COG0380G III.E essential alpha,alpha-trehalose-phosphate synthase KEEP 3909739..3909889 3909739 3909752 I NA NA IG3549_Rv3490-Rv3491 KEEP 3909739..3909889 3909753 3909823 I NA NA IG3549_Rv3490-Rv3491 Only Marin et al 2022 KEEP 3909739..3909889 3909824 3909889 I NA NA IG3549_Rv3490-Rv3491 KEEP 3909890..3910468 3909890 3910468 + 192 15610627 - Rv3491 - VI nonessential hypothetical protein KEEP 3910465..3910947 3910465 3910947 - 160 15610628 - Rv3492c - V nonessential Mce associated protein KEEP 3910947..3911675 3910947 3911675 - 242 15610629 - Rv3493c - V nonessential Mce associated alanine and valine rich protein KEEP 3911675..3913369 3911675 3913369 - 564 15610630 mce4F Rv3494c COG1463Q IV.A nonessential MCE-family protein MCE4F KEEP 3913370..3913379 3913370 3913379 I NA NA IG3553_Rv3494c-Rv3495c KEEP 3913380..3914534 3913380 3914534 - 384 15610631 lprN Rv3495c COG1463Q II.C.1 essential MCE-family lipoprotein LprN KEEP 3914531..3915886 3914531 3915886 - 451 15610632 mce4D Rv3496c COG1463Q IV.A nonessential MCE-family protein MCE4D KEEP 3915883..3916956 3915883 3916956 - 357 15610633 mce4C Rv3497c COG1463Q IV.A essential MCE-family protein MCE4C KEEP 3916946..3917998 3916946 3917998 - 350 15610634 mce4B Rv3498c COG1463Q IV.A nonessential MCE-family protein MCE4B KEEP 3917998..3919200 3917998 3919200 - 400 57117113 mce4A Rv3499c COG1463Q IV.A essential MCE-family protein MCE4A KEEP 3919201..3919219 3919201 3919219 I NA NA IG3558_Rv3499c-Rv3500c KEEP 3919220..3920062 3919220 3920062 - 280 15610636 yrbE4B Rv3500c COG0767Q IV.A nonessential integral membrane protein YrbE4b KEEP 3920063..3920096 3920063 3920096 I NA NA IG3559_Rv3500c-Rv3501c KEEP 3920097..3920861 3920097 3920469 - 254 15610637 yrbE4A Rv3501c COG0767Q IV.A essential integral membrane protein YrbE4a KEEP 3920097..3920861 3920470 3920549 - 254 15610637 yrbE4A Rv3501c COG0767Q IV.A essential integral membrane protein YrbE4a Only Marin et al 2022 KEEP 3920097..3920861 3920550 3920861 - 254 15610637 yrbE4A Rv3501c COG0767Q IV.A essential integral membrane protein YrbE4a KEEP 3920862..3921086 3920862 3921086 I NA NA IG3560_Rv3501c-Rv3502c KEEP 3921087..3922040 3921087 3922040 - 317 15610638 fabG Rv3502c COG1028IQR VI essential 3-ketoacyl-(acyl-carrier-protein) reductase KEEP 3922041..3922064 3922041 3922064 I NA NA IG3561_Rv3502c-Rv3503c KEEP 3922065..3922256 3922065 3922256 - 63 15610639 fdxD Rv3503c COG1141C I.B.6c nonessential ferredoxin FdxD KEEP 3922257..3922470 3922257 3922470 I NA NA IG3562_Rv3503c-Rv3504 KEEP 3922471..3923673 3922471 3923673 + 400 15610640 fadE26 Rv3504 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE26 KEEP 3923674..3923697 3923674 3923697 I NA NA IG3563_Rv3504-Rv3505 KEEP 3923698..3924819 3923698 3924819 + 373 15610641 fadE27 Rv3505 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE27 KEEP 3924820..3924889 3924820 3924889 I NA NA IG3564_Rv3505-Rv3506 KEEP 3924890..3926398 3924890 3926398 + 502 15610642 fadD17 Rv3506 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 3926399..3926568 3926399 3926568 I NA NA IG3565_Rv3506-Rv3507 KEEP 3926569..3930714 3926569 3930714 + 1381 57117114 PE_PGRS53 Rv3507 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3930715..3931004 3930715 3930984 I NA NA IG3566_Rv3507-Rv3508 repeat KEEP 3930715..3931004 3930985 3931004 I NA NA IG3566_Rv3507-Rv3508 repeat Annotation + Marin et al 2022 DISCARD 3931005..3936710 3931005 3936710 + 1901 57117115 PE_PGRS54 Rv3508 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3936711..3936876 3936711 3936876 I NA NA IG3567_Rv3508-Rv3509c KEEP 3936877..3938424 3936877 3938424 - 515 15610645 ilvX Rv3509c COG0028EH I.D.7 nonessential hypothetical protein KEEP 3938421..3939257 3938421 3939257 - 278 15610646 - Rv3510c COG2159R V nonessential hypothetical protein KEEP 3939258..3939616 3939258 3939616 I NA NA IG3569_Rv3510c-Rv3511 KEEP 3939617..3941761 3939617 3941761 + 714 57117116 PE_PGRS55 Rv3511 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3941724..3944963 3941724 3944963 + 1079 57117117 PE_PGRS56 Rv3512 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3944964..3945091 3944964 3945088 I NA NA IG3571_Rv3512-Rv3513c KEEP 3944964..3945091 3945089 3945091 I NA NA IG3571_Rv3512-Rv3513c Annotation + Marin et al 2022 DISCARD 3945092..3945748 3945092 3945604 - 218 15610649 fadD18 Rv3513c COG0318IQ I.A.3 nonessential fatty-acid-CoA ligase Only Marin et al 2022 KEEP 3945092..3945748 3945605 3945748 - 218 15610649 fadD18 Rv3513c COG0318IQ I.A.3 nonessential fatty-acid-CoA ligase KEEP 3945749..3945793 3945749 3945773 I NA NA IG3572_Rv3513c-Rv3514 KEEP 3945749..3945793 3945774 3945793 I NA NA IG3572_Rv3513c-Rv3514 Annotation + Marin et al 2022 DISCARD 3945794..3950263 3945794 3950263 + 1489 57117118 PE_PGRS57 Rv3514 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 3950264..3950823 3950264 3950820 I NA NA IG3573_Rv3514-Rv3515c KEEP 3950264..3950823 3950821 3950823 I NA NA IG3573_Rv3514-Rv3515c Annotation + Marin et al 2022 DISCARD 3950824..3952470 3950824 3951336 - 548 57117119 fadD19 Rv3515c COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 3950824..3952470 3951337 3952470 - 548 57117119 fadD19 Rv3515c COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 3952471..3952543 3952471 3952543 I NA NA IG3574_Rv3515c-Rv3516 KEEP 3952544..3953335 3952544 3953331 + 263 15610652 echA19 Rv3516 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 3952544..3953335 3953332 3953335 + 263 15610652 echA19 Rv3516 COG1024I I.A.3 nonessential enoyl-CoA hydratase Only Marin et al 2022 KEEP 3953336..3953430 3953336 3953403 I NA NA IG3575_Rv3516-Rv3517 Only Marin et al 2022 KEEP 3953336..3953430 3953404 3953430 I NA NA IG3575_Rv3516-Rv3517 KEEP 3953431..3954270 3953431 3954270 + 279 15610653 - Rv3517 COG0507L V nonessential hypothetical protein KEEP 3954271..3954324 3954271 3954324 I NA NA IG3576_Rv3517-Rv3518c KEEP 3954325..3955521 3954325 3955521 - 398 15610654 cyp142 Rv3518c COG2124Q IV.F nonessential cytochrome P450 monooxygenase 142 KEEP 3955522..3955549 3955522 3955549 I NA NA IG3577_Rv3518c-Rv3519 KEEP 3955550..3956260 3955550 3956260 + 236 15610655 - Rv3519 - VI essential hypothetical protein KEEP 3956261..3956324 3956261 3956324 I NA NA IG3578_Rv3519-Rv3520c KEEP 3956325..3957368 3956325 3957368 - 347 15610656 - Rv3520c COG2141C I.B.7 nonessential coenzyme F420-dependent oxidoreductase KEEP 3957369..3957520 3957369 3957520 I NA NA IG3579_Rv3520c-Rv3521 KEEP 3957521..3958432 3957521 3958432 + 303 15610657 - Rv3521 COG1545R V nonessential hypothetical protein KEEP 3958433..3958447 3958433 3958447 I NA NA IG3580_Rv3521-Rv3522 KEEP 3958448..3959512 3958448 3959512 + 354 15610658 ltp4 Rv3522 COG0183I I.J.1 nonessential lipid-transfer protein KEEP 3959513..3959528 3959513 3959528 I NA NA IG3581_Rv3522-Rv3523 KEEP 3959529..3960713 3959529 3960713 + 394 15610659 ltp3 Rv3523 COG0183I I.H.3 essential acetyl-CoA acetyltransferase KEEP 3960714..3960754 3960714 3960754 I NA NA IG3582_Rv3523-Rv3524 KEEP 3960755..3961786 3960755 3961786 + 343 15610660 - Rv3524 COG3391S II.C.4 nonessential hypothetical protein KEEP 3961787..3961799 3961787 3961799 I NA NA IG3583_Rv3524-Rv3525c KEEP 3961800..3962324 3961800 3962324 - 174 15610661 - Rv3525c COG0663R I.G.14 nonessential siderophore-binding protein KEEP 3962325..3962438 3962325 3962438 I NA NA IG3584_Rv3525c-Rv3526 KEEP 3962439..3963599 3962439 3963599 + 386 15610662 - Rv3526 COG4638PR I.B.7 nonessential oxidoreductase KEEP 3963600..3963604 3963600 3963604 I NA NA IG3585_Rv3526-Rv3527 KEEP 3963605..3964054 3963605 3964054 + 149 15610663 - Rv3527 - VI nonessential hypothetical protein KEEP 3964055..3964478 3964055 3964478 I NA NA IG3586_Rv3527-Rv3528c KEEP 3964479..3965192 3964479 3965192 - 237 15610664 - Rv3528c - VI nonessential hypothetical protein KEEP 3965193..3965883 3965193 3965883 I NA NA IG3587_Rv3528c-Rv3529c KEEP 3965884..3967038 3965884 3967038 - 384 15610665 - Rv3529c - V nonessential hypothetical protein KEEP 3967038..3967820 3967038 3967820 - 260 15610666 - Rv3530c COG1028IQR II.B.6 nonessential short chain dehydrogenase KEEP 3967817..3968944 3967817 3968944 - 375 15610667 - Rv3531c - VI nonessential hypothetical protein KEEP 3968945..3969342 3968945 3969342 I NA NA IG3590_Rv3531c-Rv3532 KEEP 3969343..3970563 3969343 3970563 + 406 57117120 PPE61 Rv3532 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3970564..3970704 3970564 3970704 I NA NA IG3591_Rv3532-Rv3533c repeat KEEP 3970705..3972453 3970705 3971369 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3970705..3972453 3971370 3971455 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3970705..3972453 3971456 3971457 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3970705..3972453 3971458 3971524 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3970705..3972453 3971525 3971980 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3970705..3972453 3971981 3972034 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3970705..3972453 3972035 3972080 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3970705..3972453 3972081 3972195 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3970705..3972453 3972196 3972210 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3970705..3972453 3972211 3972290 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3970705..3972453 3972291 3972336 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3970705..3972453 3972337 3972393 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3970705..3972453 3972394 3972453 - 582 57117121 PPE62 Rv3533c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3972454..3972551 3972454 3972551 I NA NA IG3592_Rv3533c-Rv3534c KEEP 3972552..3973592 3972552 3973592 - 346 15610670 - Rv3534c COG0119E II.B.6 essential 4-hydroxy-2-ketovalerate aldolase KEEP 3973589..3974500 3973589 3974500 - 303 15610671 - Rv3535c COG4569Q I.B.7 nonessential acetaldehyde dehydrogenase KEEP 3974501..3974510 3974501 3974510 I NA NA IG3594_Rv3535c-Rv3536c KEEP 3974511..3975296 3974511 3975296 - 261 15610672 - Rv3536c COG3971Q II.B.6 nonessential hydratase KEEP 3975297..3975368 3975297 3975368 I NA NA IG3595_Rv3536c-Rv3537 KEEP 3975369..3977060 3975369 3977060 + 563 15610673 - Rv3537 COG1053C VI nonessential 3-ketosteroid-delta-1-dehydrogenase KEEP 3977062..3977922 3977062 3977922 + 286 57117122 - Rv3538 COG2030I I.H.2 essential dehydrogenase KEEP 3977923..3978058 3977923 3978058 I NA NA IG3597_Rv3538-Rv3539 KEEP 3978059..3979498 3978059 3979498 + 479 57117123 PPE63 Rv3539 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3979499..3980659 3979499 3980659 - 386 15610676 ltp2 Rv3540c COG0183I III.A.5 essential lipid-transfer protein KEEP 3980659..3981048 3980659 3981048 - 129 15610677 - Rv3541c - V essential hypothetical protein KEEP 3981045..3981980 3981045 3981980 - 311 15610678 - Rv3542c COG1545R V essential hypothetical protein KEEP 3981977..3983140 3981977 3983140 - 387 15610679 fadE29 Rv3543c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE29 KEEP 3983125..3984144 3983125 3984144 - 339 15610680 fadE28 Rv3544c COG1960I I.A.3 essential acyl-CoA dehydrogenase FADE28 KEEP 3984144..3985445 3984144 3985445 - 433 15610681 cyp125 Rv3545c COG2124Q IV.F essential cytochrome P450 125 KEEP 3985446..3985556 3985446 3985556 I NA NA IG3604_Rv3545c-Rv3546 KEEP 3985557..3986732 3985557 3986732 + 391 15610682 fadA5 Rv3546 COG0183I I.A.3 nonessential acetyl-CoA acetyltransferase KEEP 3986733..3986843 3986733 3986843 I NA NA IG3605_Rv3546-Rv3547 KEEP 3986844..3987299 3986844 3987299 + 151 15610683 - Rv3547 - V nonessential hypothetical protein KEEP 3987300..3987381 3987300 3987381 I NA NA IG3606_Rv3547-Rv3548c KEEP 3987382..3988296 3987382 3988296 - 304 15610684 - Rv3548c COG1028IQR VI nonessential short chain dehydrogenase KEEP 3988297..3988318 3988297 3988318 I NA NA IG3607_Rv3548c-Rv3549c KEEP 3988319..3989098 3988319 3989098 - 259 15610685 - Rv3549c COG1028IQR VI nonessential short chain dehydrogenase KEEP 3989099..3989152 3989099 3989152 I NA NA IG3608_Rv3549c-Rv3550 KEEP 3989153..3989896 3989153 3989896 + 247 15610686 echA20 Rv3550 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 3989896..3990774 3989896 3990774 + 292 15610687 - Rv3551 COG1788I I.A.2 essential CoA-transferase subunit alpha KEEP 3990771..3991523 3990771 3991523 + 250 15610688 - Rv3552 COG2057I IV.H nonessential CoA-transferase subunit beta KEEP 3991524..3991620 3991524 3991560 I NA NA IG3611_Rv3552-Rv3553 KEEP 3991524..3991620 3991561 3991619 I NA NA IG3611_Rv3552-Rv3553 Only Marin et al 2022 KEEP 3991524..3991620 3991620 3991620 I NA NA IG3611_Rv3552-Rv3553 KEEP 3991621..3992688 3991621 3992688 + 355 15610689 - Rv3553 COG2070R I.B.7 nonessential oxidoreductase KEEP 3992685..3994742 3992685 3994742 + 685 15610690 fdxB Rv3554 COG1018C,COG3239I I.B.6c nonessential electron transfer protein FdxB KEEP 3994743..3994829 3994743 3994829 I NA NA IG3613_Rv3554-Rv3555c KEEP 3994830..3995699 3994830 3995699 - 289 15610691 - Rv3555c - V nonessential hypothetical protein KEEP 3995700..3995803 3995700 3995803 I NA NA IG3614_Rv3555c-Rv3556c KEEP 3995804..3996964 3995804 3996964 - 386 15610692 fadA6 Rv3556c COG0183I I.A.3 essential acetyl-CoA acetyltransferase KEEP 3996965..3997028 3996965 3997028 I NA NA IG3615_Rv3556c-Rv3557c KEEP 3997029..3997631 3997029 3997631 - 200 15610693 - Rv3557c COG1309K I.J.1 nonessential TetR family transcriptional regulator KEEP 3997632..3997979 3997632 3997979 I NA NA IG3616_Rv3557c-Rv3558 KEEP 3997980..3999638 3997980 3998149 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3997980..3999638 3998150 3998204 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3997980..3999638 3998205 3998606 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3997980..3999638 3998607 3998613 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3997980..3999638 3998614 3998823 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3997980..3999638 3998824 3998942 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3997980..3999638 3998943 3998990 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3997980..3999638 3998991 3999071 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 3997980..3999638 3999072 3999638 + 552 57117124 PPE64 Rv3558 - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 3999639..3999646 3999639 3999646 I NA NA IG3617_Rv3558-Rv3559c KEEP 3999647..4000435 3999647 4000435 - 262 15610695 - Rv3559c COG1028IQR I.B.7 essential short chain dehydrogenase KEEP 4000432..4001589 4000432 4001589 - 385 15610696 fadE30 Rv3560c COG1960I I.A.3 essential acyl-CoA dehydrogenase FADE30 KEEP 4001590..4001636 4001590 4001636 I NA NA IG3619_Rv3560c-Rv3561 KEEP 4001637..4003160 4001637 4003160 + 507 15610697 fadD3 Rv3561 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 4003161..4004294 4003161 4004294 + 377 15610698 fadE31 Rv3562 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE31 KEEP 4004291..4005250 4004291 4005250 + 319 15610699 fadE32 Rv3563 COG1960I I.A.3 essential acyl-CoA dehydrogenase FADE32 KEEP 4005247..4006203 4005247 4006203 + 318 15610700 fadE33 Rv3564 COG1960I I.A.3 essential acyl-CoA dehydrogenase FADE33 KEEP 4006200..4007366 4006200 4007366 + 388 15610701 aspB Rv3565 COG0436E I.D.2 nonessential aspartate aminotransferase KEEP 4007331..4008182 4007331 4008182 - 283 57117125 nat Rv3566c COG2162Q VI DR-inh nonessential arylamine n-acetyltransferase nat (arylamine acetylase) KEEP 4008167..4008433 4008167 4008433 - 88 57117126 - Rv3566A - I.C.1 nonessential hypothetical protein KEEP 4008434..4008718 4008434 4008718 I NA NA IG3626_Rv3566A-Rv3567c KEEP 4008719..4009282 4008719 4009282 - 187 15610703 - Rv3567c COG1853R I.B.7 nonessential oxidoreductase KEEP 4009283..4009296 4009283 4009296 I NA NA IG3627_Rv3567c-Rv3568c KEEP 4009297..4010199 4009297 4010199 - 300 15610704 bphC Rv3568c COG0346E VII nonessential biphenyl-2,3-diol 1,2-dioxygenase KEEP 4010196..4011071 4010196 4011071 - 291 15610705 bphD Rv3569c COG0596R IV.I nonessential 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD KEEP 4011072..4011085 4011072 4011085 I NA NA IG3629_Rv3569c-Rv3570c KEEP 4011086..4012270 4011086 4012270 - 394 15610706 - Rv3570c COG1960I I.B.7 nonessential oxidoreductase KEEP 4012271..4012416 4012271 4012416 I NA NA IG3630_Rv3570c-Rv3571 KEEP 4012417..4013493 4012417 4013493 + 358 15610707 hmp Rv3571 COG1018C I.B.7 nonessential hemoglobine-like protein KEEP 4013494..4013510 4013494 4013510 I NA NA IG3631_Rv3571-Rv3572 KEEP 4013511..4014041 4013511 4014041 + 176 15610708 - Rv3572 - VI nonessential hypothetical protein KEEP 4014042..4014076 4014042 4014076 I NA NA IG3632_Rv3572-Rv3573c KEEP 4014077..4016212 4014077 4016212 - 711 15610709 fadE34 Rv3573c COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE34 KEEP 4016213..4016483 4016213 4016483 I NA NA IG3633_Rv3573c-Rv3574 KEEP 4016484..4017083 4016484 4017083 + 199 15610710 - Rv3574 COG1309K I.J.1 essential transcriptional regulatory protein TetR-family KEEP 4017084..4017088 4017084 4017088 I NA NA IG3634_Rv3574-Rv3575c KEEP 4017089..4018168 4017089 4018168 - 359 15610711 - Rv3575c COG1609K I.J.1 nonessential transcriptional regulatory protein LacI-family KEEP 4018169..4018357 4018169 4018357 I NA NA IG3635_Rv3575c-Rv3576 KEEP 4018358..4019071 4018358 4019071 + 237 57117127 lppH Rv3576 - II.C.1 nonessential lipoprotein LppH KEEP 4019072..4019261 4019072 4019261 I NA NA IG3636_Rv3576-Rv3577 KEEP 4019262..4020128 4019262 4020128 + 288 15610713 - Rv3577 COG2220R V nonessential hypothetical protein KEEP 4020129..4020141 4020129 4020141 I NA NA IG3637_Rv3577-Rv3578 KEEP 4020142..4021383 4020142 4021383 + 413 15610714 arsB2 Rv3578 COG1055P III.A.4 nonessential arsenical PUMP integral membrane protein ArsB2 KEEP 4021384..4021424 4021384 4021387 I NA NA IG3638_Rv3578-Rv3579c KEEP 4021384..4021424 4021388 4021424 I NA NA IG3638_Rv3578-Rv3579c Only Marin et al 2022 KEEP 4021425..4022393 4021425 4021460 - 322 15610715 - Rv3579c COG0566J IV.H essential tRNA/rRNA methyltransferase Only Marin et al 2022 KEEP 4021425..4022393 4021461 4022393 - 322 15610715 - Rv3579c COG0566J IV.H essential tRNA/rRNA methyltransferase KEEP 4022394..4023803 4022394 4023803 - 469 57117128 cysS Rv3580c COG0215J II.A.3 essential cysteinyl-tRNA synthetase KEEP 4023804..4023867 4023804 4023867 I NA NA IG3640_Rv3580c-Rv3581c KEEP 4023868..4024347 4023868 4024347 - 159 15610717 ispF Rv3581c COG0245I VII essential 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase KEEP 4024344..4025039 4024344 4025039 - 231 15610718 ispD Rv3582c COG1211I IV.H essential 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase KEEP 4025040..4025055 4025040 4025055 I NA NA IG3642_Rv3582c-Rv3583c KEEP 4025056..4025544 4025056 4025544 - 162 15610719 - Rv3583c COG1329K I.J.1 nonessential transcription factor KEEP 4025545..4025829 4025545 4025829 I NA NA IG3643_Rv3583c-Rv3584 KEEP 4025830..4026378 4025830 4026378 + 182 15610720 lpqE Rv3584 - II.C.1 nonessential lipoprotein LpqE KEEP 4026379..4026443 4026379 4026443 I NA NA IG3644_Rv3584-Rv3585 KEEP 4026444..4027886 4026444 4027886 + 480 15610721 radA Rv3585 COG1066O II.A.5 nonessential DNA repair protein RadA KEEP 4027887..4027890 4027887 4027890 I NA NA IG3645_Rv3585-Rv3586 KEEP 4027891..4028967 4027891 4028967 + 358 15610722 - Rv3586 COG1623R V nonessential DNA integrity scanning protein DisA KEEP 4028968..4029762 4028968 4029762 - 264 15610723 - Rv3587c - II.C.4 nonessential hypothetical protein KEEP 4029763..4029870 4029763 4029870 I NA NA IG3647_Rv3587c-Rv3588c KEEP 4029871..4030494 4029871 4030494 - 207 15610724 - Rv3588c COG0288P VII essential carbonic anhydrase KEEP 4030493..4031407 4030493 4031407 + 304 15610725 mutY Rv3589 COG1194L II.A.5 nonessential adenine glycosylase MutY KEEP 4031404..4033158 4031404 4031605 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4031404..4033158 4031606 4031660 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4031404..4033158 4031661 4031820 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4031404..4033158 4031821 4031838 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4031404..4033158 4031839 4031923 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4031404..4033158 4031924 4031943 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4031404..4033158 4031944 4031954 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4031404..4033158 4031955 4032014 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4031404..4033158 4032015 4032018 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4031404..4033158 4032019 4032024 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4031404..4033158 4032025 4032381 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4031404..4033158 4032382 4032639 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4031404..4033158 4032640 4032756 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4031404..4033158 4032757 4032820 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4031404..4033158 4032821 4033158 - 584 57117129 PE_PGRS58 Rv3590c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4033159..4033268 4033159 4033268 I NA NA IG3650_Rv3590c-Rv3591c KEEP 4033269..4034042 4033269 4034042 - 257 15610727 - Rv3591c COG0596R IV.I nonessential hydrolase KEEP 4034043..4034056 4034043 4034056 I NA NA IG3651_Rv3591c-Rv3592 KEEP 4034057..4034374 4034057 4034374 + 105 15610728 TB11.2 Rv3592 COG2329R V nonessential hypothetical protein KEEP 4034352..4035710 4034352 4035710 + 452 15610729 lpqF Rv3593 COG2367V II.C.1 essential lipoprotein LpqF KEEP 4035711..4035856 4035711 4035856 I NA NA IG3653_Rv3593-Rv3594 KEEP 4035857..4036684 4035857 4036684 + 275 15610730 - Rv3594 - V nonessential hypothetical protein KEEP 4036685..4036730 4036685 4036730 I NA NA IG3654_Rv3594-Rv3595c KEEP 4036731..4038050 4036731 4036845 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4036731..4038050 4036846 4037194 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4036731..4038050 4037195 4037348 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4036731..4038050 4037349 4037350 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4036731..4038050 4037351 4037352 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4036731..4038050 4037353 4037354 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4036731..4038050 4037355 4037445 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4036731..4038050 4037446 4037497 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4036731..4038050 4037498 4037831 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4036731..4038050 4037832 4037883 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein Annotation + Marin et al 2022 DISCARD 4036731..4038050 4037884 4038050 - 439 57117130 PE_PGRS59 Rv3595c - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4038051..4038157 4038051 4038157 I NA NA IG3655_Rv3595c-Rv3596c KEEP 4038158..4040704 4038158 4038740 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 KEEP 4038158..4040704 4038741 4038794 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 Only Marin et al 2022 KEEP 4038158..4040704 4038795 4038843 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 KEEP 4038158..4040704 4038844 4038882 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 Only Marin et al 2022 KEEP 4038158..4040704 4038883 4039674 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 KEEP 4038158..4040704 4039675 4039747 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 Only Marin et al 2022 KEEP 4038158..4040704 4039748 4040021 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 KEEP 4038158..4040704 4040022 4040104 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 Only Marin et al 2022 KEEP 4038158..4040704 4040105 4040704 - 848 57117131 clpC1 Rv3596c COG0542O II.B.3 essential ATP-dependent protease ATP-binding subunit ClpC1 KEEP 4040705..4040980 4040705 4040980 I NA NA IG3656_Rv3596c-Rv3597c KEEP 4040981..4041319 4040981 4041319 - 112 15610733 lsr2 Rv3597c - I.J.1 essential iron-regulated LSR2 protein precursor KEEP 4041320..4041422 4041320 4041422 I NA NA IG3657_Rv3597c-Rv3598c KEEP 4041423..4042940 4041423 4042940 - 505 15610734 lysS Rv3598c COG1190J II.A.3 essential lysyl-tRNA synthetase KEEP 4042941..4042951 4042941 4042951 I NA NA IG3658_Rv3598c-Rv3599c KEEP 4042952..4043035 4042952 4043035 - 27 15610735 - Rv3599c - VI nonessential hypothetical protein KEEP 4043036..4043040 4043036 4043040 I NA NA IG3659_Rv3599c-Rv3600c KEEP 4043041..4043859 4043041 4043859 - 272 15610736 - Rv3600c COG1521K V nonessential pantothenate kinase KEEP 4043860..4043861 4043860 4043861 I NA NA IG3660_Rv3600c-Rv3601c KEEP 4043862..4044281 4043862 4044281 - 139 15610737 panD Rv3601c COG0853H I.G.5 nonessential aspartate alpha-decarboxylase KEEP 4044281..4045210 4044281 4045210 - 309 15610738 panC Rv3602c COG0414H I.G.5 essential pantoate--beta-alanine ligase KEEP 4045207..4046118 4045207 4046118 - 303 15610739 - Rv3603c COG5495S V nonessential hypothetical protein KEEP 4046119..4046302 4046119 4046302 I NA NA IG3663_Rv3603c-Rv3604c KEEP 4046303..4047496 4046303 4047496 - 397 57117132 - Rv3604c - II.C.5 essential transmembrane protein KEEP 4047497..4047704 4047497 4047704 I NA NA IG3664_Rv3604c-Rv3605c KEEP 4047705..4048181 4047705 4048181 - 158 15610741 - Rv3605c - VI nonessential hypothetical protein KEEP 4048181..4048747 4048181 4048747 - 188 15610742 folK Rv3606c COG0801H I.G.2 nonessential 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase FolK KEEP 4048744..4049145 4048744 4049145 - 133 57117133 folB Rv3607c COG1539H I.G.2 essential dihydroneopterin aldolase FolB KEEP 4049138..4049980 4049138 4049980 - 280 57117134 folP1 Rv3608c COG0294H I.G.2 essential dihydropteroate synthase KEEP 4049977..4050585 4049977 4050585 - 202 15610745 folE Rv3609c COG0302H I.G.2 essential GTP cyclohydrolase I KEEP 4050586..4050600 4050586 4050600 I NA NA IG3669_Rv3609c-Rv3610c KEEP 4050601..4052883 4050601 4052883 - 760 15610746 ftsH Rv3610c COG0465O III.C essential membrane-bound protease FTSH (cell division protein) KEEP 4052884..4052949 4052884 4052949 I NA NA IG3670_Rv3610c-Rv3611 KEEP 4052950..4053603 4052950 4053603 + 217 15610747 - Rv3611 - VI essential hypothetical protein Only Marin et al 2022 KEEP 4053518..4053847 4053518 4053603 - 109 15610748 - Rv3612c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4053518..4053847 4053604 4053633 - 109 15610748 - Rv3612c - V nonessential hypothetical protein KEEP 4053518..4053847 4053634 4053847 - 109 15610748 - Rv3612c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4053848..4053880 4053848 4053852 I NA NA IG3672_Rv3612c-Rv3613c Only Marin et al 2022 KEEP 4053848..4053880 4053853 4053880 I NA NA IG3672_Rv3612c-Rv3613c KEEP 4053881..4054042 4053881 4054042 - 53 15610749 - Rv3613c - VI nonessential hypothetical protein KEEP 4054043..4054141 4054043 4054141 I NA NA IG3673_Rv3613c-Rv3614c KEEP 4054142..4054696 4054142 4054696 - 184 15610750 - Rv3614c - V essential hypothetical protein KEEP 4054697..4054811 4054697 4054811 I NA NA IG3674_Rv3614c-Rv3615c KEEP 4054812..4055123 4054812 4055123 - 103 15610751 - Rv3615c - V essential hypothetical protein KEEP 4055124..4055196 4055124 4055196 I NA NA IG3675_Rv3615c-Rv3616c KEEP 4055197..4056375 4055197 4056375 - 392 15610752 - Rv3616c - V essential hypothetical protein KEEP 4056376..4057732 4056376 4057732 I NA NA IG3676_Rv3616c-Rv3617 KEEP 4057733..4058701 4057733 4058701 + 322 15610753 ephA Rv3617 COG0596R III.F nonessential epoxide hydrolase EphA KEEP 4058698..4059885 4058698 4059885 + 395 15610754 - Rv3618 COG2141C VI nonessential monooxygenase KEEP 4059886..4059983 4059886 4059976 I NA NA IG3678_Rv3618-Rv3619c KEEP 4059886..4059983 4059977 4059983 I NA NA IG3678_Rv3618-Rv3619c Only Marin et al 2022 KEEP 4059984..4060268 4059984 4060268 - 94 15610755 esxV Rv3619c - VI nonessential putative ESAT-6 like protein ESXV (ESAT-6 like protein 1) Only Marin et al 2022 KEEP 4060269..4060294 4060269 4060294 I NA NA IG3679_Rv3619c-Rv3620c Only Marin et al 2022 KEEP 4060295..4060591 4060295 4060591 - 98 15610756 esxW Rv3620c - VI nonessential putative ESAT-6 like protein ESXW (ESAT-6 like protein 10) Only Marin et al 2022 KEEP 4060592..4060647 4060592 4060595 I NA NA IG3680_Rv3620c-Rv3621c Annotation + Marin et al 2022 DISCARD 4060592..4060647 4060596 4060647 I NA NA IG3680_Rv3620c-Rv3621c KEEP 4060648..4061889 4060648 4061421 - 413 57117135 PPE65 Rv3621c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 4060648..4061889 4061422 4061526 - 413 57117135 PPE65 Rv3621c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 4060648..4061889 4061527 4061889 - 413 57117135 PPE65 Rv3621c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 4061890..4061898 4061890 4061898 I NA NA IG3681_Rv3621c-Rv3622c repeat KEEP 4061899..4062198 4061899 4062198 - 99 57117136 PE32 Rv3622c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 4062199..4062526 4062199 4062526 I NA NA IG3682_Rv3622c-Rv3623 KEEP 4062527..4063249 4062527 4063249 + 240 15610759 lpqG Rv3623 COG2968S II.C.1 nonessential lipoprotein LpqG KEEP 4063250..4063253 4063250 4063253 I NA NA IG3683_Rv3623-Rv3624c KEEP 4063254..4063904 4063254 4063904 - 216 15610760 hpt Rv3624c COG0634F I.F.4 nonessential hypoxanthine-guanine phosphoribosyltransferase KEEP 4063901..4064872 4063901 4064872 - 323 15610761 mesJ Rv3625c COG0037D III.C essential cell cycle protein MESJ KEEP 4064851..4065903 4064851 4065903 - 350 15610762 - Rv3626c COG5282S V nonessential hypothetical protein KEEP 4065900..4067285 4065900 4067285 - 461 15610763 - Rv3627c COG2027M II.C.3 essential hypothetical protein KEEP 4067286..4067422 4067286 4067422 I NA NA IG3687_Rv3627c-Rv3628 KEEP 4067423..4067911 4067423 4067911 + 162 15610764 ppa Rv3628 COG0221C I.A.4 nonessential inorganic pyrophosphatase KEEP 4067912..4067956 4067912 4067956 I NA NA IG3688_Rv3628-Rv3629c KEEP 4067957..4069054 4067957 4069054 - 365 15610765 - Rv3629c COG2899S II.C.5 nonessential integral membrane protein KEEP 4069055..4069174 4069055 4069174 I NA NA IG3689_Rv3629c-Rv3630 KEEP 4069175..4070470 4069175 4070032 + 431 15610766 - Rv3630 - II.C.5 nonessential integral membrane protein KEEP 4069175..4070470 4070033 4070083 + 431 15610766 - Rv3630 - II.C.5 nonessential integral membrane protein Only Marin et al 2022 KEEP 4069175..4070470 4070084 4070260 + 431 15610766 - Rv3630 - II.C.5 nonessential integral membrane protein KEEP 4069175..4070470 4070261 4070347 + 431 15610766 - Rv3630 - II.C.5 nonessential integral membrane protein Only Marin et al 2022 KEEP 4069175..4070470 4070348 4070470 + 431 15610766 - Rv3630 - II.C.5 nonessential integral membrane protein KEEP 4070471..4070513 4070471 4070513 I NA NA IG3690_Rv3630-Rv3631 KEEP 4070514..4071239 4070514 4071239 + 241 15610767 - Rv3631 COG0463M IV.H essential transferase KEEP 4071236..4071580 4071236 4071580 + 114 15610768 - Rv3632 - II.C.5 nonessential hypothetical protein KEEP 4071581..4071790 4071581 4071790 I NA NA IG3692_Rv3632-Rv3633 KEEP 4071791..4072666 4071791 4072666 + 291 15610769 - Rv3633 COG5285Q V nonessential hypothetical protein KEEP 4072667..4073611 4072667 4073611 - 314 57117137 galE1 Rv3634c COG0451MG I.C.3 essential UDP-glucose 4-epimerase GALE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) KEEP 4073612..4073633 4073612 4073633 I NA NA IG3694_Rv3634c-Rv3635 KEEP 4073634..4075409 4073634 4075409 + 591 15610771 - Rv3635 - II.C.5 essential transmembrane protein KEEP 4075410..4075751 4075410 4075751 I NA NA IG3695_Rv3635-Rv3636 KEEP 4075752..4076099 4075752 4076099 + 115 15610772 - Rv3636 COG4584L IV.B.1 phage nonessential transposase KEEP 4076100..4076483 4076100 4076483 I NA NA IG3696_Rv3636-Rv3637 repeat KEEP 4076484..4076984 4076484 4076984 + 166 15610773 - Rv3637 COG4584L IV.B.1 phage nonessential transposase KEEP 4076984..4077730 4076984 4077655 + 248 15610774 - Rv3638 COG1484L IV.B.1 phage nonessential transposase KEEP 4076984..4077730 4077656 4077706 + 248 15610774 - Rv3638 COG1484L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4076984..4077730 4077707 4077730 + 248 15610774 - Rv3638 COG1484L IV.B.1 phage nonessential transposase KEEP 4077731..4077883 4077731 4077787 I NA NA IG3698_Rv3638-Rv3639c KEEP 4077731..4077883 4077788 4077860 I NA NA IG3698_Rv3638-Rv3639c Annotation + Marin et al 2022 DISCARD 4077731..4077883 4077861 4077883 I NA NA IG3698_Rv3638-Rv3639c KEEP 4077884..4078450 4077884 4077889 - 188 15610775 - Rv3639c - V nonessential hypothetical protein KEEP 4077884..4078450 4077890 4077961 - 188 15610775 - Rv3639c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4077884..4078450 4077962 4077976 - 188 15610775 - Rv3639c - V nonessential hypothetical protein KEEP 4077884..4078450 4077977 4078205 - 188 15610775 - Rv3639c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4077884..4078450 4078206 4078450 - 188 15610775 - Rv3639c - V nonessential hypothetical protein KEEP 4078451..4078519 4078451 4078519 I NA NA IG3699_Rv3639c-Rv3640c KEEP 4078520..4079749 4078520 4079749 - 409 15610776 - Rv3640c COG3328L IV.B.1 nonessential transposase KEEP 4079750..4079924 4079750 4079924 I NA NA IG3700_Rv3640c-Rv3641c KEEP 4079925..4080560 4079925 4080560 - 211 15610777 fic Rv3641c COG2184D III.C nonessential cell filamentation protein FIC KEEP 4080561..4080570 4080561 4080570 I NA NA IG3701_Rv3641c-Rv3642c KEEP 4080571..4080765 4080571 4080765 - 64 15610778 - Rv3642c - VI nonessential hypothetical protein KEEP 4080766..4081159 4080766 4081159 I NA NA IG3702_Rv3642c-Rv3643 KEEP 4081160..4081351 4081160 4081351 + 63 15610779 - Rv3643 - VI nonessential hypothetical protein KEEP 4081352..4081515 4081352 4081515 I NA NA IG3703_Rv3643-Rv3644c KEEP 4081516..4082721 4081516 4082721 - 401 15610780 - Rv3644c COG0470L II.A.5 nonessential DNA polymerase III subunit delta' KEEP 4082722..4082806 4082722 4082806 I NA NA IG3704_Rv3644c-Rv3645 KEEP 4082807..4084456 4082807 4084456 + 549 15610781 - Rv3645 COG2114T II.C.5 nonessential transmembrane protein KEEP 4084453..4087257 4084453 4087257 - 934 15610782 topA Rv3646c COG0550L,COG1754R II.A.5 essential DNA topoisomerase I KEEP 4087258..4087609 4087258 4087475 I NA NA IG3706_Rv3646c-Rv3647c KEEP 4087258..4087609 4087476 4087609 I NA NA IG3706_Rv3646c-Rv3647c Only Marin et al 2022 KEEP 4087610..4088188 4087610 4087626 - 192 15610783 - Rv3647c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4087610..4088188 4087627 4088188 - 192 15610783 - Rv3647c - V nonessential hypothetical protein KEEP 4088189..4088327 4088189 4088327 I NA NA IG3707_Rv3647c-Rv3648c KEEP 4088328..4088531 4088328 4088531 - 67 15610784 cspA Rv3648c COG1278K III.E essential cold shock protein A KEEP 4088532..4088780 4088532 4088780 I NA NA IG3708_Rv3648c-Rv3649 KEEP 4088781..4091096 4088781 4090856 + 771 15610785 - Rv3649 COG1205R II.A.7 essential helicase KEEP 4088781..4091096 4090857 4090910 + 771 15610785 - Rv3649 COG1205R II.A.7 essential helicase Only Marin et al 2022 KEEP 4088781..4091096 4090911 4091096 + 771 15610785 - Rv3649 COG1205R II.A.7 essential helicase KEEP 4091097..4091232 4091097 4091232 I NA NA IG3709_Rv3649-Rv3650 KEEP 4091233..4091517 4091233 4091335 + 94 57117138 PE33 Rv3650 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 4091233..4091517 4091336 4091423 + 94 57117138 PE33 Rv3650 - IV.C.1 PE/PPE/PGRS nonessential PE family protein Annotation + Marin et al 2022 DISCARD 4091233..4091517 4091424 4091517 + 94 57117138 PE33 Rv3650 - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 4091518..4091840 4091518 4091840 I NA NA IG3710_Rv3650-Rv3651 KEEP 4091841..4092878 4091841 4092878 + 345 15610787 - Rv3651 - V essential hypothetical protein KEEP 4092879..4093631 4092879 4093631 I NA NA IG3711_Rv3651-Rv3652 KEEP 4093632..4093946 4093632 4093946 + 104 57117139 PE_PGRS60 Rv3652 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family-related protein KEEP 4093940..4094527 4093940 4094065 + 195 57117140 PE_PGRS61 Rv3653 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family-related protein KEEP 4093940..4094527 4094066 4094346 + 195 57117140 PE_PGRS61 Rv3653 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family-related protein Annotation + Marin et al 2022 DISCARD 4093940..4094527 4094347 4094527 + 195 57117140 PE_PGRS61 Rv3653 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family-related protein KEEP 4094528..4094659 4094528 4094659 I NA NA IG3713_Rv3653-Rv3654c KEEP 4094660..4094914 4094660 4094914 - 84 15610790 - Rv3654c - V nonessential hypothetical protein KEEP 4094915..4094922 4094915 4094922 I NA NA IG3714_Rv3654c-Rv3655c KEEP 4094923..4095300 4094923 4095300 - 125 15610791 - Rv3655c - V nonessential hypothetical protein KEEP 4095301..4095323 4095301 4095323 I NA NA IG3715_Rv3655c-Rv3656c KEEP 4095324..4095530 4095324 4095530 - 68 15610792 - Rv3656c - V nonessential hypothetical protein KEEP 4095531..4095539 4095531 4095539 I NA NA IG3716_Rv3656c-Rv3657c KEEP 4095540..4096115 4095540 4096115 - 191 15610793 - Rv3657c COG2064NU II.C.5 nonessential hypothetical protein KEEP 4096116..4096138 4096116 4096138 I NA NA IG3717_Rv3657c-Rv3658c KEEP 4096139..4096939 4096139 4096939 - 266 15610794 - Rv3658c - II.C.5 essential transmembrane protein KEEP 4096936..4097994 4096936 4097994 - 352 57117141 - Rv3659c COG4962U V nonessential hypothetical protein KEEP 4097995..4098095 4097995 4098095 I NA NA IG3719_Rv3659c-Rv3660c KEEP 4098096..4099148 4098096 4099148 - 350 15610796 - Rv3660c - V essential hypothetical protein KEEP 4099149..4099646 4099149 4099646 I NA NA IG3720_Rv3660c-Rv3661 KEEP 4099647..4100510 4099647 4100510 + 287 15610797 - Rv3661 COG0560E V nonessential hypothetical protein KEEP 4100511..4101264 4100511 4101191 I NA NA IG3721_Rv3661-Rv3662c KEEP 4100511..4101264 4101192 4101256 I NA NA IG3721_Rv3661-Rv3662c Only Marin et al 2022 KEEP 4100511..4101264 4101257 4101264 I NA NA IG3721_Rv3661-Rv3662c KEEP 4101265..4102035 4101265 4102035 - 256 15610798 - Rv3662c COG3177S V nonessential hypothetical protein KEEP 4102032..4103678 4102032 4103678 - 548 15610799 dppD Rv3663c COG1123R III.A.1 essential peptide ABC transporter ATP-binding protein KEEP 4103675..4104475 4103675 4104475 - 266 15610800 dppC Rv3664c COG1173EP III.A.1 nonessential peptide ABC transporter transmembrane protein KEEP 4104476..4104530 4104476 4104530 I NA NA IG3724_Rv3664c-Rv3665c KEEP 4104531..4105457 4104531 4105457 - 308 15610801 dppB Rv3665c COG0601EP III.A.1 nonessential peptide ABC transporter transmembrane protein KEEP 4105459..4107084 4105459 4107084 - 541 15610802 dppA Rv3666c COG4166E III.A.1 essential periplasmic dipeptide-binding lipoprotein DppA KEEP 4107085..4107791 4107085 4107449 I NA NA IG3726_Rv3666c-Rv3667 KEEP 4107085..4107791 4107450 4107526 I NA NA IG3726_Rv3666c-Rv3667 Only Marin et al 2022 KEEP 4107085..4107791 4107527 4107791 I NA NA IG3726_Rv3666c-Rv3667 KEEP 4107792..4109747 4107792 4109747 + 651 15610803 acs Rv3667 COG0365I I.A.3 nonessential acetyl-CoA synthetase KEEP 4109748..4109782 4109748 4109782 I NA NA IG3727_Rv3667-Rv3668c KEEP 4109783..4110481 4109783 4110481 - 232 15610804 - Rv3668c - II.B.3 nonessential protease KEEP 4110482..4110826 4110482 4110826 I NA NA IG3728_Rv3668c-Rv3669 KEEP 4110827..4111345 4110827 4111345 + 172 15610805 - Rv3669 - II.C.5 essential transmembrane protein KEEP 4111346..4112329 4111346 4112329 + 327 15610806 ephE Rv3670 COG0596R III.F nonessential epoxide hydrolase EphE KEEP 4112322..4113515 4112322 4113515 - 397 15610807 - Rv3671c COG0265O II.B.3 nonessential membrane-associated serine protease KEEP 4113516..4113520 4113516 4113520 I NA NA IG3731_Rv3671c-Rv3672c KEEP 4113521..4114342 4113521 4114342 - 273 15610808 - Rv3672c COG0494LR V nonessential hypothetical protein KEEP 4114343..4114473 4114343 4114473 I NA NA IG3732_Rv3672c-Rv3673c KEEP 4114474..4115157 4114474 4115157 - 227 15610809 - Rv3673c COG0526OC II.C.5 nonessential membrane-anchored thioredoxin-like protein KEEP 4115157..4115894 4115157 4115894 - 245 57117142 nth Rv3674c COG0177L II.A.5 nonessential endonuclease III KEEP 4115895..4116001 4115895 4116001 I NA NA IG3734_Rv3674c-Rv3675 KEEP 4116002..4116379 4116002 4116379 + 125 15610811 - Rv3675 - II.C.5 nonessential hypothetical protein KEEP 4116380..4116477 4116380 4116477 I NA NA IG3735_Rv3675-Rv3676 KEEP 4116478..4117152 4116478 4117152 + 224 15610812 - Rv3676 COG0664T I.J.1 nonessential CRP/FNR family transcriptional regulator KEEP 4117153..4117257 4117153 4117257 I NA NA IG3736_Rv3676-Rv3677c KEEP 4117258..4118052 4117258 4118052 - 264 15610813 - Rv3677c COG0491R IV.I nonessential hydrolase KEEP 4118053..4118058 4118053 4118058 I NA NA IG3737_Rv3677c-Rv3678c KEEP 4118059..4118514 4118059 4118514 - 151 15610814 - Rv3678c COG0251J V nonessential hypothetical protein KEEP 4118515..4118529 4118515 4118529 I NA NA IG3738_Rv3678c-Rv3678A KEEP 4118530..4118691 4118530 4118691 - 53 57117143 - Rv3678A - I.J.1 nonessential hypothetical protein KEEP 4118692..4118775 4118692 4118775 I NA NA IG3739_Rv3678A-Rv3679 KEEP 4118776..4119798 4118776 4119798 + 340 15610815 - Rv3679 COG0003P III.A.4 essential anion transporter ATPase KEEP 4119795..4120955 4119795 4120912 + 386 15610816 - Rv3680 COG0003P III.A.4 nonessential anion transporter ATPase KEEP 4119795..4120955 4120913 4120955 + 386 15610816 - Rv3680 COG0003P III.A.4 nonessential anion transporter ATPase Marin et al 2022 + homoplasy analysis DISCARD 4120956..4121197 4120956 4121197 I NA NA IG3741_Rv3680-Rv3681c Only Marin et al 2022 KEEP 4121198..4121554 4121198 4121554 - 118 57117144 whiB4 Rv3681c - I.J.1 nonessential transcriptional regulatory protein WHIB-like WHIB4 KEEP 4121555..4121915 4121555 4121915 I NA NA IG3742_Rv3681c-Rv3682 KEEP 4121916..4124348 4121916 4124348 + 810 57117145 ponA2 Rv3682 COG0744M II.C.3 nonessential bifunctional membrane-associated penicillin-binding protein 1A/1B KEEP 4124349..4124416 4124349 4124416 I NA NA IG3743_Rv3682-Rv3683 KEEP 4124417..4125376 4124417 4125376 + 319 15610819 - Rv3683 COG1408R V essential hypothetical protein KEEP 4125377..4125438 4125377 4125438 I NA NA IG3744_Rv3683-Rv3684 KEEP 4125439..4126479 4125439 4126479 + 346 15610820 - Rv3684 COG0031E IV.I nonessential lyase KEEP 4126480..4127294 4126480 4127294 I NA NA IG3745_Rv3684-Rv3685c KEEP 4127295..4128725 4127295 4128725 - 476 15610821 cyp137 Rv3685c COG2124Q IV.F nonessential cytochrome P450 137 KEEP 4128726..4128750 4128726 4128750 I NA NA IG3746_Rv3685c-Rv3686c KEEP 4128751..4129083 4128751 4129083 - 110 15610822 - Rv3686c - V nonessential hypothetical protein KEEP 4129084..4129322 4129084 4129322 I NA NA IG3747_Rv3686c-Rv3687c KEEP 4129323..4129691 4129323 4129691 - 122 15610823 rsfB Rv3687c COG1366T II.A.7 nonessential anti-anti-sigma factor RSFB (anti-sigma factor antagonist) (regulator of sigma F B) KEEP 4129692..4129892 4129692 4129892 I NA NA IG3748_Rv3687c-Rv3688c KEEP 4129893..4130357 4129893 4130357 - 154 15610824 - Rv3688c COG1610S V nonessential hypothetical protein KEEP 4130357..4131712 4130357 4131712 + 451 15610825 - Rv3689 - II.C.5 nonessential transmembrane protein KEEP 4131713..4131738 4131713 4131738 I NA NA IG3750_Rv3689-Rv3690 KEEP 4131739..4132392 4131739 4132392 + 217 15610826 - Rv3690 - II.C.4 nonessential hypothetical protein KEEP 4132393..4132517 4132393 4132517 I NA NA IG3751_Rv3690-Rv3691 KEEP 4132518..4133519 4132518 4133519 + 333 15610827 - Rv3691 - V nonessential hypothetical protein KEEP 4133516..4134592 4133516 4134592 + 358 15610828 moxR2 Rv3692 COG0714R I.J.1 nonessential methanol dehydrogenase transcriptional regulatory protein MOXR2 KEEP 4134593..4134725 4134593 4134599 I NA NA IG3753_Rv3692-Rv3693 KEEP 4134593..4134725 4134600 4134725 I NA NA IG3753_Rv3692-Rv3693 Only Marin et al 2022 KEEP 4134726..4136048 4134726 4134730 + 440 15610829 - Rv3693 COG1721R II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 4134726..4136048 4134731 4136048 + 440 15610829 - Rv3693 COG1721R II.C.5 nonessential hypothetical protein KEEP 4136049..4136121 4136049 4136121 I NA NA IG3754_Rv3693-Rv3694c KEEP 4136122..4137114 4136122 4137114 - 330 15610830 - Rv3694c COG1300S II.C.5 nonessential transmembrane protein KEEP 4137115..4137205 4137115 4137205 I NA NA IG3755_Rv3694c-Rv3695 KEEP 4137206..4138138 4137206 4138138 + 310 15610831 - Rv3695 COG1714S II.C.5 nonessential hypothetical protein KEEP 4138139..4138201 4138139 4138201 I NA NA IG3756_Rv3695-Rv3696c KEEP 4138202..4139755 4138202 4139501 - 517 15610832 glpK Rv3696c COG0554C I.A.1 nonessential glycerol kinase KEEP 4138202..4139755 4139502 4139569 - 517 15610832 glpK Rv3696c COG0554C I.A.1 nonessential glycerol kinase Only Marin et al 2022 KEEP 4138202..4139755 4139570 4139755 - 517 15610832 glpK Rv3696c COG0554C I.A.1 nonessential glycerol kinase KEEP 4139756..4139804 4139756 4139804 I NA NA IG3757_Rv3696c-Rv3697c KEEP 4139805..4140242 4139805 4140242 - 145 15610833 - Rv3697c COG1848R II.C.5 nonessential hypothetical protein KEEP 4140243..4140492 4140243 4140492 I NA NA IG3758_Rv3697c-Rv3698 KEEP 4140493..4142022 4140493 4142022 + 509 15610834 - Rv3698 - V nonessential hypothetical protein KEEP 4142023..4142043 4142023 4142043 I NA NA IG3759_Rv3698-Rv3699 KEEP 4142044..4142745 4142044 4142745 + 233 15610835 - Rv3699 COG0500QR V nonessential hypothetical protein KEEP 4142746..4142747 4142746 4142747 I NA NA IG3760_Rv3699-Rv3700c KEEP 4142748..4143920 4142748 4143899 - 390 15610836 - Rv3700c COG0520E IV.D nonessential hypothetical protein KEEP 4142748..4143920 4143900 4143920 - 390 15610836 - Rv3700c COG0520E IV.D nonessential hypothetical protein Only Marin et al 2022 KEEP 4143921..4143950 4143921 4143950 I NA NA IG3761_Rv3700c-Rv3701c Only Marin et al 2022 KEEP 4143951..4144916 4143951 4143956 - 321 15610837 - Rv3701c COG4301S V essential hypothetical protein Only Marin et al 2022 KEEP 4143951..4144916 4143957 4144916 - 321 15610837 - Rv3701c COG4301S V essential hypothetical protein KEEP 4144913..4145614 4144913 4145614 - 233 15610838 - Rv3702c COG0121R V nonessential hypothetical protein KEEP 4145614..4146891 4145614 4146891 - 425 15610839 - Rv3703c COG1262S V nonessential hypothetical protein KEEP 4146888..4148186 4146888 4148186 - 432 15610840 gshA Rv3704c COG3572H I.D.1 nonessential glutamate--cysteine ligase gshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) KEEP 4148187..4148317 4148187 4148317 I NA NA IG3765_Rv3704c-Rv3705c KEEP 4148318..4148962 4148318 4148962 - 214 15610841 - Rv3705c - V nonessential hypothetical protein KEEP 4148963..4149090 4148963 4149090 I NA NA IG3766_Rv3705c-Rv3705A KEEP 4149091..4149480 4149091 4149480 - 129 57117146 - Rv3705A - V nonessential proline rich protein KEEP 4149481..4149590 4149481 4149590 I NA NA IG3767_Rv3705A-Rv3706c KEEP 4149591..4149911 4149591 4149911 - 106 15610842 - Rv3706c - V nonessential proline rich protein KEEP 4149912..4150029 4149912 4150029 I NA NA IG3768_Rv3706c-Rv3707c KEEP 4150030..4151040 4150030 4151040 - 336 15610843 - Rv3707c - V nonessential hypothetical protein KEEP 4151041..4151179 4151041 4151179 I NA NA IG3769_Rv3707c-Rv3708c KEEP 4151180..4152217 4151180 4152217 - 345 15610844 asd Rv3708c COG0136E I.D.2 essential aspartate-semialdehyde dehydrogenase KEEP 4152218..4153483 4152218 4153483 - 421 15610845 ask Rv3709c COG0527E I.D.2 essential aspartate kinase KEEP 4153484..4153859 4153484 4153859 I NA NA IG3771_Rv3709c-Rv3710 KEEP 4153860..4155674 4153860 4155452 + 604 161352459 leuA Rv3710 COG0119E I.D.7 essential 2-isopropylmalate synthase KEEP 4153860..4155674 4155453 4155589 + 604 161352459 leuA Rv3710 COG0119E I.D.7 essential 2-isopropylmalate synthase Marin et al 2022 + homoplasy analysis DISCARD 4153860..4155674 4155590 4155674 + 604 161352459 leuA Rv3710 COG0119E I.D.7 essential 2-isopropylmalate synthase KEEP 4155675..4155739 4155675 4155739 I NA NA IG3772_Rv3710-Rv3711c KEEP 4155740..4156729 4155740 4156729 - 329 15610847 dnaQ Rv3711c COG0847L II.A.5 nonessential DNA polymerase III subunit epsilon KEEP 4156730..4156980 4156730 4156792 I NA NA IG3773_Rv3711c-Rv3712 KEEP 4156730..4156980 4156793 4156975 I NA NA IG3773_Rv3711c-Rv3712 Only Marin et al 2022 KEEP 4156730..4156980 4156976 4156980 I NA NA IG3773_Rv3711c-Rv3712 KEEP 4156981..4158222 4156981 4158222 + 413 15610848 - Rv3712 COG0769M VI essential ligase KEEP 4158223..4158226 4158223 4158226 I NA NA IG3774_Rv3712-Rv3713 KEEP 4158227..4158922 4158227 4158922 + 231 15610849 cobQ2 Rv3713 COG3442R I.G.13 essential cobyric acid synthase CobQ2 KEEP 4158923..4158930 4158923 4158930 I NA NA IG3775_Rv3713-Rv3714c KEEP 4158931..4159821 4158931 4159821 - 296 15610850 - Rv3714c - V nonessential hypothetical protein KEEP 4159822..4159888 4159822 4159888 I NA NA IG3776_Rv3714c-Rv3715c KEEP 4159889..4160500 4159889 4160500 - 203 15610851 recR Rv3715c COG0353L II.A.5 nonessential recombination protein RecR KEEP 4160501..4160511 4160501 4160511 I NA NA IG3777_Rv3715c-Rv3716c KEEP 4160512..4160913 4160512 4160913 - 133 15610852 - Rv3716c COG0718S V nonessential hypothetical protein KEEP 4160914..4161047 4160914 4161047 I NA NA IG3778_Rv3716c-Rv3717 KEEP 4161048..4161773 4161048 4161773 + 241 15610853 - Rv3717 COG0860M II.B.4 essential hypothetical protein KEEP 4161774..4161814 4161774 4161814 I NA NA IG3779_Rv3717-Rv3718c KEEP 4161815..4162258 4161815 4162258 - 147 15610854 - Rv3718c - V nonessential hypothetical protein KEEP 4162259..4162305 4162259 4162305 I NA NA IG3780_Rv3718c-Rv3719 KEEP 4162306..4163718 4162306 4163718 + 470 15610855 - Rv3719 COG0277C V nonessential hypothetical protein KEEP 4163719..4163735 4163719 4163735 I NA NA IG3781_Rv3719-Rv3720 KEEP 4163736..4164998 4163736 4164998 + 420 15610856 - Rv3720 COG2230M I.H.3 nonessential fatty acid synthase KEEP 4164995..4166731 4164995 4166731 - 578 15610857 dnaZX Rv3721c COG2812L II.A.5 essential DNA polymerase III subunits gamma and tau KEEP 4166732..4166820 4166732 4166820 I NA NA IG3783_Rv3721c-Rv3722c KEEP 4166821..4168128 4166821 4168128 - 435 57117147 - Rv3722c COG1167KE V essential hypothetical protein KEEP 4168129..4168535 4168129 4168469 I NA NA IG3784_Rv3722c-Rv3723 KEEP 4168129..4168535 4168470 4168482 I NA NA IG3784_Rv3722c-Rv3723 Only Marin et al 2022 KEEP 4168129..4168535 4168483 4168535 I NA NA IG3784_Rv3722c-Rv3723 KEEP 4168536..4169300 4168536 4169300 + 254 15610859 - Rv3723 - II.C.5 essential transmembrane protein KEEP 4169301..4169466 4169301 4169466 I NA NA IG3785_Rv3723-Rv3724A KEEP 4169467..4169709 4169467 4169709 + 80 57117148 cut5a Rv3724A - IV.I nonessential cutinase precursor KEEP 4169606..4170169 4169606 4170169 + 187 57117149 cut5b Rv3724B - IV.I nonessential cutinase KEEP 4170170..4170213 4170170 4170213 I NA NA IG3787_Rv3724B-Rv3725 KEEP 4170214..4171143 4170214 4171143 + 309 15610861 - Rv3725 COG0451MG I.B.7 nonessential oxidoreductase KEEP 4171144..4171420 4171144 4171420 I NA NA IG3788_Rv3725-Rv3726 KEEP 4171421..4172614 4171421 4172614 + 397 15610862 - Rv3726 COG1063ER VI nonessential dehydrogenase KEEP 4172615..4172954 4172615 4172954 I NA NA IG3789_Rv3726-Rv3727 KEEP 4172955..4174763 4172955 4174763 + 602 15610863 - Rv3727 COG3349S I.B.7 nonessential oxidoreductase KEEP 4174764..4174872 4174764 4174872 I NA NA IG3790_Rv3727-Rv3728 KEEP 4174873..4178070 4174873 4175391 + 1065 15610864 - Rv3728 COG0477GEPR,COG1752R II.C.5 nonessential hypothetical protein KEEP 4174873..4178070 4175392 4175410 + 1065 15610864 - Rv3728 COG0477GEPR,COG1752R II.C.5 nonessential hypothetical protein Only Marin et al 2022 KEEP 4174873..4178070 4175411 4178070 + 1065 15610864 - Rv3728 COG0477GEPR,COG1752R II.C.5 nonessential hypothetical protein KEEP 4178071..4178284 4178071 4178284 I NA NA IG3791_Rv3728-Rv3729 KEEP 4178285..4180615 4178285 4180615 + 776 15610865 - Rv3729 COG0500QR,COG1964R IV.H nonessential transferase KEEP 4180616..4180679 4180616 4180679 I NA NA IG3792_Rv3729-Rv3730c KEEP 4180680..4181720 4180680 4181720 - 346 15610866 - Rv3730c COG3285L V nonessential hypothetical protein KEEP 4181721..4181757 4181721 4181757 I NA NA IG3793_Rv3730c-Rv3731 KEEP 4181758..4182834 4181758 4182834 + 358 15610867 ligC Rv3731 COG1793L II.A.5 nonessential ATP-dependent DNA ligase KEEP 4182835..4182933 4182835 4182933 I NA NA IG3794_Rv3731-Rv3732 KEEP 4182934..4183992 4182934 4183992 + 352 15610868 - Rv3732 COG4402S V nonessential hypothetical protein KEEP 4183993..4184011 4183993 4184011 I NA NA IG3795_Rv3732-Rv3733c KEEP 4184012..4184512 4184012 4184512 - 166 15610869 - Rv3733c COG4119LR V nonessential hypothetical protein KEEP 4184513..4184525 4184513 4184525 I NA NA IG3796_Rv3733c-Rv3734c KEEP 4184526..4185890 4184526 4185890 - 454 15610870 - Rv3734c - V nonessential hypothetical protein KEEP 4185891..4186088 4185891 4186088 I NA NA IG3797_Rv3734c-Rv3735 KEEP 4186089..4186577 4186089 4186577 + 162 15610871 - Rv3735 COG1839S V nonessential hypothetical protein KEEP 4186578..4186633 4186578 4186633 I NA NA IG3798_Rv3735-Rv3736 KEEP 4186634..4187695 4186634 4187695 + 353 15610872 - Rv3736 COG2207K I.J.1 nonessential transcriptional regulatory protein AraC/XylS-family KEEP 4187696..4187698 4187696 4187698 I NA NA IG3799_Rv3736-Rv3737 KEEP 4187699..4189288 4187699 4189288 + 529 15610873 - Rv3737 COG2966S,COG3610S II.C.5 nonessential transmembrane protein KEEP 4189285..4190232 4189285 4189438 - 315 57117150 PPE66 Rv3738c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 4189285..4190232 4189439 4189509 - 315 57117150 PPE66 Rv3738c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 4189285..4190232 4189510 4190055 - 315 57117150 PPE66 Rv3738c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 4189285..4190232 4190056 4190144 - 315 57117150 PPE66 Rv3738c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein Annotation + Marin et al 2022 DISCARD 4189285..4190232 4190145 4190232 - 315 57117150 PPE66 Rv3738c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 4190233..4190283 4190233 4190283 I NA NA IG3801_Rv3738c-Rv3739c repeat KEEP 4190284..4190517 4190284 4190517 - 77 57117151 PPE67 Rv3739c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 4190518..4190832 4190518 4190832 I NA NA IG3802_Rv3739c-Rv3740c KEEP 4190833..4192179 4190833 4192179 - 448 15610876 - Rv3740c - V nonessential hypothetical protein KEEP 4192179..4192853 4192179 4192853 - 224 15610877 - Rv3741c COG2072P I.B.7 nonessential oxidoreductase KEEP 4192850..4193245 4192850 4193245 - 131 15610878 - Rv3742c COG2072P I.B.7 nonessential oxidoreductase KEEP 4193246..4193390 4193246 4193390 I NA NA IG3805_Rv3742c-Rv3743c KEEP 4193391..4195373 4193391 4195373 - 660 15610879 ctpJ Rv3743c COG2217P III.A.2 nonessential cation transporter P-type ATPase CtpJ KEEP 4195374..4195439 4195374 4195439 I NA NA IG3806_Rv3743c-Rv3744 KEEP 4195440..4195802 4195440 4195802 + 120 15610880 - Rv3744 COG0640K I.J.1 nonessential transcriptional regulatory protein ArsR-family KEEP 4195803..4195885 4195803 4195885 I NA NA IG3807_Rv3744-Rv3745c KEEP 4195886..4196098 4195886 4196098 - 70 15610881 - Rv3745c COG3651S V nonessential hypothetical protein KEEP 4196099..4196170 4196099 4196170 I NA NA IG3808_Rv3745c-Rv3746c KEEP 4196171..4196506 4196171 4196506 - 111 57117152 PE34 Rv3746c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 4196507..4196723 4196507 4196723 I NA NA IG3809_Rv3746c-Rv3747 KEEP 4196724..4197107 4196724 4197107 + 127 15610883 - Rv3747 - V nonessential hypothetical protein KEEP 4197108..4197235 4197108 4197235 I NA NA IG3810_Rv3747-Rv3748 KEEP 4197236..4197595 4197236 4197595 + 119 15610884 - Rv3748 - V nonessential hypothetical protein KEEP 4197596..4197627 4197596 4197627 I NA NA IG3811_Rv3748-Rv3749c KEEP 4197628..4198137 4197628 4198137 - 169 15610885 - Rv3749c - V nonessential hypothetical protein KEEP 4198138..4198204 4198138 4198204 I NA NA IG3812_Rv3749c-Rv3750c KEEP 4198205..4198597 4198205 4198597 - 130 15610886 - Rv3750c - IV.B.3 nonessential excisionase KEEP 4198598..4198873 4198598 4198873 I NA NA IG3813_Rv3750c-Rv3751 KEEP 4198874..4199089 4198874 4199089 + 71 15610887 - Rv3751 COG0582L IV.B.3 phage nonessential integrase KEEP 4199090..4199246 4199090 4199121 I NA NA IG3814_Rv3751-Rv3752c KEEP 4199090..4199246 4199122 4199189 I NA NA IG3814_Rv3751-Rv3752c Annotation + Marin et al 2022 DISCARD 4199090..4199246 4199190 4199246 I NA NA IG3814_Rv3751-Rv3752c KEEP 4199247..4199705 4199247 4199705 - 152 15610888 - Rv3752c COG0590FJ I.F.3 essential cytidine/deoxycytidylate deaminase KEEP 4199706..4199720 4199706 4199720 I NA NA IG3815_Rv3752c-Rv3753c KEEP 4199721..4200221 4199721 4200221 - 166 15610889 - Rv3753c - V nonessential hypothetical protein KEEP 4200222..4200420 4200222 4200420 I NA NA IG3816_Rv3753c-Rv3754 KEEP 4200421..4201326 4200421 4201239 + 301 15610890 tyrA Rv3754 COG0287E I.D.4 nonessential prephenate dehydrogenase KEEP 4200421..4201326 4201240 4201294 + 301 15610890 tyrA Rv3754 COG0287E I.D.4 nonessential prephenate dehydrogenase Only Marin et al 2022 KEEP 4200421..4201326 4201295 4201326 + 301 15610890 tyrA Rv3754 COG0287E I.D.4 nonessential prephenate dehydrogenase KEEP 4201289..4201888 4201289 4201294 - 199 15610891 - Rv3755c COG3554S V nonessential hypothetical protein Only Marin et al 2022 KEEP 4201289..4201888 4201295 4201888 - 199 15610891 - Rv3755c COG3554S V nonessential hypothetical protein KEEP 4201889..4201893 4201889 4201893 I NA NA IG3818_Rv3755c-Rv3756c KEEP 4201894..4202613 4201894 4202613 - 239 15610892 proZ Rv3756c COG1174E III.E nonessential osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter PROZ KEEP 4202610..4203299 4202610 4203299 - 229 15610893 proW Rv3757c COG1174E III.E nonessential osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter PROW KEEP 4203287..4204417 4203287 4204417 - 376 15610894 proV Rv3758c COG1125E III.E essential osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter PROV KEEP 4204418..4204425 4204418 4204425 I NA NA IG3821_Rv3758c-Rv3759c KEEP 4204426..4205373 4204426 4205373 - 315 15610895 proX Rv3759c COG1732M III.E nonessential osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein PROX KEEP 4205374..4205537 4205374 4205537 I NA NA IG3822_Rv3759c-Rv3760 KEEP 4205538..4205840 4205538 4205840 + 100 15610896 - Rv3760 - II.C.5 nonessential hypothetical protein KEEP 4205841..4205861 4205841 4205861 I NA NA IG3823_Rv3760-Rv3761c KEEP 4205862..4206917 4205862 4206917 - 351 15610897 fadE36 Rv3761c COG3173R I.A.3 nonessential acyl-CoA dehydrogenase KEEP 4206918..4206995 4206918 4206995 I NA NA IG3824_Rv3761c-Rv3762c KEEP 4206996..4208876 4206996 4208876 - 626 15610898 - Rv3762c COG2015Q I.C.5 nonessential hydrolase KEEP 4208877..4209046 4208877 4209046 I NA NA IG3825_Rv3762c-Rv3763 KEEP 4209047..4209526 4209047 4209526 + 159 15610899 lpqH Rv3763 - II.C.1 nonessential 19 kDa lipoprotein antigen precursor LPQH KEEP 4209527..4209581 4209527 4209581 I NA NA IG3826_Rv3763-Rv3764c KEEP 4209582..4211009 4209582 4211009 - 475 15610900 - Rv3764c COG0642T I.J.2 nonessential two component sensor kinase KEEP 4211010..4211079 4211010 4211079 I NA NA IG3827_Rv3764c-Rv3765c KEEP 4211080..4211784 4211080 4211784 - 234 15610901 - Rv3765c COG0745TK I.J.2 nonessential two component transcriptional regulatory protein KEEP 4211785..4212292 4211785 4212292 I NA NA IG3828_Rv3765c-Rv3766 KEEP 4212293..4212982 4212293 4212982 + 229 15610902 - Rv3766 - VI nonessential hypothetical protein KEEP 4212983..4212995 4212983 4212995 I NA NA IG3829_Rv3766-Rv3767c KEEP 4212996..4213940 4212996 4213940 - 314 15610903 - Rv3767c COG3315Q V nonessential hypothetical protein KEEP 4213941..4214069 4213941 4214069 I NA NA IG3830_Rv3767c-Rv3768 KEEP 4214070..4214429 4214070 4214429 + 119 15610904 - Rv3768 - VI nonessential hypothetical protein KEEP 4214430..4214614 4214430 4214614 I NA NA IG3831_Rv3768-Rv3769 KEEP 4214615..4214887 4214615 4214887 + 90 15610905 - Rv3769 COG0840NT VI nonessential hypothetical protein KEEP 4214888..4215199 4214888 4215199 I NA NA IG3832_Rv3769-Rv3770c KEEP 4215200..4215775 4215200 4215775 - 191 15610906 - Rv3770c - IV.B.1 nonessential hypothetical protein KEEP 4215776..4215880 4215776 4215880 I NA NA IG3833_Rv3770c-Rv3770A KEEP 4215881..4216063 4215881 4216063 - 60 57117153 - Rv3770A - VI nonessential hypothetical protein KEEP 4216064..4216077 4216064 4216077 I NA NA IG3834_Rv3770A-Rv3770B KEEP 4216078..4216269 4216078 4216125 - 63 57117154 - Rv3770B - IV.B.1 nonessential hypothetical protein KEEP 4216078..4216269 4216126 4216269 - 63 57117154 - Rv3770B - IV.B.1 nonessential hypothetical protein Only Marin et al 2022 KEEP 4216270..4216403 4216270 4216272 I NA NA IG3835_Rv3770B-Rv3771c Only Marin et al 2022 KEEP 4216270..4216403 4216273 4216346 I NA NA IG3835_Rv3770B-Rv3771c KEEP 4216270..4216403 4216347 4216403 I NA NA IG3835_Rv3770B-Rv3771c Only Marin et al 2022 KEEP 4216404..4216730 4216404 4216431 - 108 15610907 - Rv3771c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4216404..4216730 4216432 4216590 - 108 15610907 - Rv3771c - V nonessential hypothetical protein KEEP 4216404..4216730 4216591 4216699 - 108 15610907 - Rv3771c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4216404..4216730 4216700 4216730 - 108 15610907 - Rv3771c - V nonessential hypothetical protein KEEP 4216731..4217133 4216731 4217133 I NA NA IG3836_Rv3771c-Rv3772 KEEP 4217134..4218195 4217134 4218195 + 353 15610908 hisC2 Rv3772 COG0079E I.D.5 nonessential putative aminotransferase KEEP 4218196..4218240 4218196 4218240 I NA NA IG3837_Rv3772-Rv3773c KEEP 4218241..4218825 4218241 4218825 - 194 15610909 - Rv3773c - V nonessential hypothetical protein KEEP 4218826..4218848 4218826 4218848 I NA NA IG3838_Rv3773c-Rv3774 KEEP 4218849..4219673 4218849 4219673 + 274 15610910 echA21 Rv3774 COG1024I I.A.3 nonessential enoyl-CoA hydratase KEEP 4219674..4219684 4219674 4219684 I NA NA IG3839_Rv3774-Rv3775 KEEP 4219685..4220932 4219685 4220932 + 415 15610911 lipE Rv3775 COG1680V II.B.5 nonessential lipase LipE KEEP 4220933..4221088 4220933 4221088 I NA NA IG3840_Rv3775-Rv3776 KEEP 4221089..4222648 4221089 4221244 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4221245 4221301 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4221089..4222648 4221302 4221340 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4221341 4221418 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4221089..4222648 4221419 4221503 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4221504 4221577 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4221089..4222648 4221578 4221580 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4221581 4221643 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4221089..4222648 4221644 4221748 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4221749 4221799 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4221089..4222648 4221800 4222094 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4222095 4222154 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Marin et al 2022 + homoplasy analysis DISCARD 4221089..4222648 4222155 4222318 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4222319 4222393 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4221089..4222648 4222394 4222463 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4222464 4222523 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4221089..4222648 4222524 4222571 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4221089..4222648 4222572 4222639 + 519 15610912 - Rv3776 - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4221089..4222648 4222640 4222648 + 519 15610912 - Rv3776 - V nonessential hypothetical protein KEEP 4222649..4222693 4222649 4222693 I NA NA IG3841_Rv3776-Rv3777 KEEP 4222694..4223680 4222694 4223680 + 328 15610913 - Rv3777 COG0604CR I.B.7 nonessential oxidoreductase KEEP 4223681..4223698 4223681 4223698 I NA NA IG3842_Rv3777-Rv3778c KEEP 4223699..4224895 4223699 4224895 - 398 15610914 - Rv3778c COG0520E IV.H essential aminotransferase KEEP 4224896..4224984 4224896 4224984 I NA NA IG3843_Rv3778c-Rv3779 KEEP 4224985..4226985 4224985 4226985 + 666 15610915 - Rv3779 - II.C.5 nonessential transmembrane protein alanine and leucine rich KEEP 4226986..4226988 4226986 4226988 I NA NA IG3844_Rv3779-Rv3780 KEEP 4226989..4227525 4226989 4227525 + 178 15610916 - Rv3780 - V nonessential hypothetical protein KEEP 4227526..4227528 4227526 4227528 I NA NA IG3845_Rv3780-Rv3781 KEEP 4227529..4228350 4227529 4228350 + 273 15610917 rfbE Rv3781 COG1134GM III.A essential o-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE KEEP 4228347..4229261 4228347 4229261 + 304 57117155 - Rv3782 COG1216R II.C.2 essential L-rhamnosyltransferase KEEP 4229258..4230100 4229258 4230100 + 280 15610919 rfbD Rv3783 COG1682GM II.C.5 nonessential O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD KEEP 4230101..4230255 4230101 4230255 I NA NA IG3848_Rv3783-Rv3784 KEEP 4230256..4231236 4230256 4231236 + 326 57117156 - Rv3784 COG0451MG I.C.3 nonessential dTDP-glucose 4,6-dehydratase KEEP 4231237..4231319 4231237 4231319 I NA NA IG3849_Rv3784-Rv3785 KEEP 4231320..4232393 4231320 4232393 + 357 15610921 - Rv3785 - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 4232374..4233597 4232374 4232393 - 407 15610922 - Rv3786c COG0463M,COG0739M VI nonessential hypothetical protein Only Marin et al 2022 KEEP 4232374..4233597 4232394 4233597 - 407 15610922 - Rv3786c COG0463M,COG0739M VI nonessential hypothetical protein KEEP 4233598..4233609 4233598 4233609 I NA NA IG3851_Rv3786c-Rv3787c KEEP 4233610..4234536 4233610 4234536 - 308 15610923 - Rv3787c COG3315Q V nonessential hypothetical protein KEEP 4234537..4234779 4234537 4234779 I NA NA IG3852_Rv3787c-Rv3788 KEEP 4234780..4235265 4234780 4235265 + 161 15610924 - Rv3788 COG0782K VI nonessential nucleoside diphosphate kinase regulator KEEP 4235266..4235373 4235266 4235373 I NA NA IG3853_Rv3788-Rv3789 KEEP 4235374..4235739 4235374 4235739 + 121 15610925 - Rv3789 COG2246S II.C.5 nonessential integral membrane protein KEEP 4235740..4235778 4235740 4235778 I NA NA IG3854_Rv3789-Rv3790 KEEP 4235779..4237164 4235779 4237164 + 461 15610926 - Rv3790 COG0277C I.B.7 essential oxidoreductase KEEP 4237165..4237929 4237165 4237929 + 254 15610927 - Rv3791 COG1028IQR VI essential short chain dehydrogenase KEEP 4237930..4237931 4237930 4237931 I NA NA IG3856_Rv3791-Rv3792 KEEP 4237932..4239863 4237932 4237998 + 643 15610928 - Rv3792 - II.C.5 essential transmembrane protein Only Marin et al 2022 KEEP 4237932..4239863 4237999 4239863 + 643 15610928 - Rv3792 - II.C.5 essential transmembrane protein KEEP 4239863..4243147 4239863 4240441 + 1094 15610929 embC Rv3793 - II.C.2 DR-emb essential integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) KEEP 4239863..4243147 4240442 4240492 + 1094 15610929 embC Rv3793 - II.C.2 DR-emb essential integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) Only Marin et al 2022 KEEP 4239863..4243147 4240493 4243147 + 1094 15610929 embC Rv3793 - II.C.2 DR-emb essential integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) KEEP 4243148..4243232 4243148 4243232 I NA NA IG3858_Rv3793-Rv3794 DR-emb KEEP 4243233..4246517 4243233 4246517 + 1094 15610930 embA Rv3794 - II.C.2 DR-emb essential integral membrane indolylacetylinositol arabinosyltransferase EMBA (arabinosylindolylacetylinositol synthase) KEEP 4246514..4249810 4246514 4247056 + 1098 15610931 embB Rv3795 - II.C.2 DR-emb-inh-rif essential integral membrane indolylacetylinositol arabinosyltransferase EMBB (arabinosylindolylacetylinositol synthase) KEEP 4246514..4249810 4247057 4247107 + 1098 15610931 embB Rv3795 - II.C.2 DR-emb-inh-rif essential integral membrane indolylacetylinositol arabinosyltransferase EMBB (arabinosylindolylacetylinositol synthase) Only Marin et al 2022 KEEP 4246514..4249810 4247108 4249810 + 1098 15610931 embB Rv3795 - II.C.2 DR-emb-inh-rif essential integral membrane indolylacetylinositol arabinosyltransferase EMBB (arabinosylindolylacetylinositol synthase) KEEP 4249811..4249877 4249811 4249877 I NA NA IG3860_Rv3795-Rv3796 KEEP 4249878..4251005 4249878 4251005 + 375 57117157 - Rv3796 COG1234R I.C.5 nonessential hypothetical protein KEEP 4251006..4251084 4251006 4251084 I NA NA IG3861_Rv3796-Rv3797 KEEP 4251085..4252866 4251085 4252866 + 593 15610933 fadE35 Rv3797 COG1960I I.A.3 nonessential acyl-CoA dehydrogenase FADE35 KEEP 4252867..4252992 4252867 4252875 I NA NA IG3862_Rv3797-Rv3798 KEEP 4252867..4252992 4252876 4252992 I NA NA IG3862_Rv3797-Rv3798 Annotation + Marin et al 2022 DISCARD 4252993..4254327 4252993 4254327 + 444 15610934 - Rv3798 COG3464L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4254328..4254379 4254328 4254339 I NA NA IG3863_Rv3798-Rv3799c Annotation + Marin et al 2022 DISCARD 4254328..4254379 4254340 4254379 I NA NA IG3863_Rv3798-Rv3799c Annotation + homoplasy analysis DISCARD 4254380..4255948 4254380 4255948 - 522 57117158 accD4 Rv3799c COG4799I I.H.1 essential propionyl-CoA carboxylase beta chain KEEP 4255945..4261146 4255945 4261146 - 1733 15610936 pks13 Rv3800c COG3319Q,COG3321Q I.I essential polyketide synthase PKS13 KEEP 4261147..4261152 4261147 4261152 I NA NA IG3865_Rv3800c-Rv3801c KEEP 4261153..4263066 4261153 4263066 - 637 15610937 fadD32 Rv3801c COG0318IQ I.A.3 essential acyl-CoA synthetase KEEP 4263067..4263354 4263067 4263354 I NA NA IG3866_Rv3801c-Rv3802c KEEP 4263355..4264365 4263355 4264365 - 336 15610938 - Rv3802c - II.C.4 essential hypothetical protein KEEP 4264366..4264562 4264366 4264562 I NA NA IG3867_Rv3802c-Rv3803c KEEP 4264563..4265462 4264563 4265462 - 299 57117159 fbpD Rv3803c COG0627R I.H.3 nonessential secreted MPT51/MPB51 antigen protein FBPD (MPT51/MPB51 antigen 85 complex C) (AG58C) (Mycolyl transferase 85C) (fibronectin-binding protein C) (85C) KEEP 4265463..4265641 4265463 4265641 I NA NA IG3868_Rv3803c-Rv3804c KEEP 4265642..4266658 4265642 4265703 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) KEEP 4265642..4266658 4265704 4265757 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) Only Marin et al 2022 KEEP 4265642..4266658 4265758 4266205 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) KEEP 4265642..4266658 4266206 4266275 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) Only Marin et al 2022 KEEP 4265642..4266658 4266276 4266314 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) KEEP 4265642..4266658 4266315 4266398 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) Only Marin et al 2022 KEEP 4265642..4266658 4266399 4266446 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) KEEP 4265642..4266658 4266447 4266530 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) Only Marin et al 2022 KEEP 4265642..4266658 4266531 4266658 - 338 15610940 fbpA Rv3804c COG0627R I.H.3 nonessential secreted antigen 85-A FBPA (Mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) KEEP 4266659..4266952 4266659 4266952 I NA NA IG3869_Rv3804c-Rv3805c KEEP 4266953..4268836 4266953 4268836 - 627 15610941 - Rv3805c - II.C.5 essential transmembrane protein KEEP 4268837..4268924 4268837 4268924 I NA NA IG3870_Rv3805c-Rv3806c KEEP 4268925..4269833 4268925 4269833 - 302 15610942 - Rv3806c COG0382H II.C.5 essential phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase KEEP 4269834..4269839 4269834 4269839 I NA NA IG3871_Rv3806c-Rv3807c KEEP 4269840..4270337 4269840 4270337 - 165 15610943 - Rv3807c COG0671I II.C.5 nonessential transmembrane protein KEEP 4270338..4270365 4270338 4270365 I NA NA IG3872_Rv3807c-Rv3808c KEEP 4270366..4272279 4270366 4272279 - 637 15610944 glfT Rv3808c COG1216R IV.H essential bifunctional UDP-galactofuranosyl transferase GLFT KEEP 4272276..4273475 4272276 4273475 - 399 15610945 glf Rv3809c COG0562M II.C.3 nonessential UDP-galactopyranose mutase Glf KEEP 4273476..4273738 4273476 4273738 I NA NA IG3874_Rv3809c-Rv3810 KEEP 4273739..4274593 4273739 4274593 + 284 15610946 pirG Rv3810 - II.C.2 essential exported repetitive protein precursor PirG (cell surface protein) (EXP53) KEEP 4274594..4274797 4274594 4274797 I NA NA IG3875_Rv3810-Rv3811 KEEP 4274798..4276417 4274798 4276417 + 539 57117160 - Rv3811 COG5479M II.C.2 nonessential hypothetical protein KEEP 4276418..4276570 4276418 4276570 I NA NA IG3876_Rv3811-Rv3812 KEEP 4276571..4278085 4276571 4278085 + 504 57117161 PE_PGRS62 Rv3812 - IV.C.1 PE/PPE/PGRS nonessential PE-PGRS family protein KEEP 4278086..4278393 4278086 4278393 I NA NA IG3877_Rv3812-Rv3813c KEEP 4278394..4279215 4278394 4279215 - 273 15610949 - Rv3813c COG0561R V nonessential hypothetical protein KEEP 4279216..4279229 4279216 4279229 I NA NA IG3878_Rv3813c-Rv3814c KEEP 4279230..4280015 4279230 4280015 - 261 15610950 - Rv3814c COG0204I IV.H nonessential acyltransferase KEEP 4280016..4280032 4280016 4280032 I NA NA IG3879_Rv3814c-Rv3815c KEEP 4280033..4280788 4280033 4280788 - 251 15610951 - Rv3815c COG0204I IV.H nonessential acyltransferase KEEP 4280789..4280791 4280789 4280791 I NA NA IG3880_Rv3815c-Rv3816c KEEP 4280792..4281571 4280792 4281571 - 259 15610952 - Rv3816c COG0204I IV.H nonessential acyltransferase KEEP 4281572..4281646 4281572 4281646 I NA NA IG3881_Rv3816c-Rv3817 KEEP 4281647..4282402 4281647 4282402 + 251 15610953 - Rv3817 COG3231J IV.D nonessential phosphotransferase KEEP 4282403..4282448 4282403 4282448 I NA NA IG3882_Rv3817-Rv3818 KEEP 4282449..4283999 4282449 4283999 + 516 15610954 - Rv3818 COG2146PR,COG2220R VI nonessential hypothetical protein KEEP 4283996..4284331 4283996 4284331 + 111 15610955 - Rv3819 - VI nonessential hypothetical protein KEEP 4284332..4284418 4284332 4284418 I NA NA IG3884_Rv3819-Rv3820c KEEP 4284419..4285825 4284419 4285825 - 468 57117162 papA2 Rv3820c COG1020Q I.I nonessential polyketide synthase associated protein PapA2 KEEP 4285826..4285972 4285826 4285972 I NA NA IG3885_Rv3820c-Rv3821 KEEP 4285973..4286686 4285973 4286686 + 237 15610957 - Rv3821 - II.C.5 nonessential integral membrane protein KEEP 4286687..4286720 4286687 4286720 I NA NA IG3886_Rv3821-Rv3822 KEEP 4286721..4287935 4286721 4287935 + 404 15610958 - Rv3822 - V nonessential hypothetical protein KEEP 4287936..4288259 4287936 4288131 I NA NA IG3887_Rv3822-Rv3823c KEEP 4287936..4288259 4288132 4288218 I NA NA IG3887_Rv3822-Rv3823c Only Marin et al 2022 KEEP 4287936..4288259 4288219 4288259 I NA NA IG3887_Rv3822-Rv3823c KEEP 4288260..4291529 4288260 4291529 - 1089 15610959 mmpL8 Rv3823c COG2409R II.C.4 nonessential integral membrane transport protein KEEP 4291530..4291638 4291530 4291638 I NA NA IG3888_Rv3823c-Rv3824c KEEP 4291639..4293174 4291639 4293174 - 511 15610960 papA1 Rv3824c COG1020Q I.I nonessential polyketide synthase associated protein KEEP 4293175..4293224 4293175 4293224 I NA NA IG3889_Rv3824c-Rv3825c KEEP 4293225..4299605 4293225 4293983 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 KEEP 4293225..4299605 4293984 4294056 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 Only Marin et al 2022 KEEP 4293225..4299605 4294057 4294401 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 KEEP 4293225..4299605 4294402 4294459 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 Only Marin et al 2022 KEEP 4293225..4299605 4294460 4294716 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 KEEP 4293225..4299605 4294717 4294773 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 Only Marin et al 2022 KEEP 4293225..4299605 4294774 4296684 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 KEEP 4293225..4299605 4296685 4296735 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 Only Marin et al 2022 KEEP 4293225..4299605 4296736 4297902 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 KEEP 4293225..4299605 4297903 4297956 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 Only Marin et al 2022 KEEP 4293225..4299605 4297957 4299605 - 2126 15610961 pks2 Rv3825c COG3321Q I.I nonessential polyketide synthase PKS2 KEEP 4299606..4299811 4299606 4299811 I NA NA IG3890_Rv3825c-Rv3826 KEEP 4299812..4301566 4299812 4301212 + 584 15610962 fadD23 Rv3826 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 4299812..4301566 4301213 4301287 + 584 15610962 fadD23 Rv3826 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 4299812..4301566 4301288 4301539 + 584 15610962 fadD23 Rv3826 COG0318IQ I.A.3 nonessential acyl-CoA synthetase KEEP 4299812..4301566 4301540 4301566 + 584 15610962 fadD23 Rv3826 COG0318IQ I.A.3 nonessential acyl-CoA synthetase Only Marin et al 2022 KEEP 4301563..4302789 4301563 4301806 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4301563..4302789 4301807 4301860 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase KEEP 4301563..4302789 4301861 4302004 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4301563..4302789 4302005 4302083 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase KEEP 4301563..4302789 4302084 4302144 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4301563..4302789 4302145 4302169 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase KEEP 4301563..4302789 4302170 4302248 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4301563..4302789 4302249 4302439 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase KEEP 4301563..4302789 4302440 4302523 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4301563..4302789 4302524 4302526 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase KEEP 4301563..4302789 4302527 4302577 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4301563..4302789 4302578 4302651 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase KEEP 4301563..4302789 4302652 4302715 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4301563..4302789 4302716 4302789 - 408 15610963 - Rv3827c COG0675L IV.B.1 phage nonessential transposase KEEP 4302786..4303397 4302786 4302867 - 203 15610964 - Rv3828c COG2452L IV.B.1 nonessential resolvase KEEP 4302786..4303397 4302868 4302924 - 203 15610964 - Rv3828c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 4302786..4303397 4302925 4302975 - 203 15610964 - Rv3828c COG2452L IV.B.1 nonessential resolvase KEEP 4302786..4303397 4302976 4303029 - 203 15610964 - Rv3828c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 4302786..4303397 4303030 4303122 - 203 15610964 - Rv3828c COG2452L IV.B.1 nonessential resolvase KEEP 4302786..4303397 4303123 4303185 - 203 15610964 - Rv3828c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 4302786..4303397 4303186 4303303 - 203 15610964 - Rv3828c COG2452L IV.B.1 nonessential resolvase KEEP 4302786..4303397 4303304 4303397 - 203 15610964 - Rv3828c COG2452L IV.B.1 nonessential resolvase Only Marin et al 2022 KEEP 4303398..4305008 4303398 4303433 - 536 15610965 - Rv3829c COG1233Q VI nonessential dehydrogenase Only Marin et al 2022 KEEP 4303398..4305008 4303434 4305008 - 536 15610965 - Rv3829c COG1233Q VI nonessential dehydrogenase KEEP 4305009..4305055 4305009 4305055 I NA NA IG3894_Rv3829c-Rv3830c KEEP 4305056..4305685 4305056 4305685 - 209 15610966 - Rv3830c COG1309K I.J.1 nonessential transcriptional regulatory protein TetR-family KEEP 4305686..4305756 4305686 4305756 I NA NA IG3895_Rv3830c-Rv3831 KEEP 4305757..4306239 4305757 4306239 + 160 15610967 - Rv3831 - VI nonessential hypothetical protein KEEP 4306236..4306811 4306236 4306811 - 191 15610968 - Rv3832c COG0500QR V nonessential hypothetical protein KEEP 4306812..4306866 4306812 4306866 I NA NA IG3897_Rv3832c-Rv3833 KEEP 4306867..4307658 4306867 4307658 + 263 15610969 - Rv3833 COG2207K I.J.1 nonessential AraC family transcriptional regulator KEEP 4307655..4308914 4307655 4308914 - 419 15610970 serS Rv3834c COG0172J II.A.3 essential seryl-tRNA synthetase KEEP 4308915..4309046 4308915 4309046 I NA NA IG3899_Rv3834c-Rv3835 KEEP 4309047..4310396 4309047 4310396 + 449 15610971 - Rv3835 - II.C.4 nonessential hypothetical protein KEEP 4310397..4310400 4310397 4310400 I NA NA IG3900_Rv3835-Rv3836 KEEP 4310401..4310814 4310401 4310814 + 137 15610972 - Rv3836 COG3824S V nonessential hypothetical protein KEEP 4310815..4311008 4310815 4311008 I NA NA IG3901_Rv3836-Rv3837c KEEP 4311009..4311707 4311009 4311707 - 232 15610973 - Rv3837c COG0406G I.B.1 nonessential phosphoglycerate mutase KEEP 4311704..4312669 4311704 4312669 - 321 15610974 pheA Rv3838c COG0077E I.D.4 nonessential prephenate dehydratase KEEP 4312670..4312764 4312670 4312764 I NA NA IG3903_Rv3838c-Rv3839 KEEP 4312765..4313541 4312765 4313541 + 258 15610975 - Rv3839 - V nonessential hypothetical protein KEEP 4313542..4313566 4313542 4313566 I NA NA IG3904_Rv3839-Rv3840 KEEP 4313567..4313980 4313567 4313980 + 137 15610976 - Rv3840 COG1316K I.J.1 nonessential transcriptional regulatory protein KEEP 4313981..4314177 4313981 4314177 I NA NA IG3905_Rv3840-Rv3841 KEEP 4314178..4314723 4314178 4314723 + 181 15610977 bfrB Rv3841 COG1528P I.G.14 nonessential bacterioferritin BfrB KEEP 4314724..4314737 4314724 4314737 I NA NA IG3906_Rv3841-Rv3842c KEEP 4314738..4315562 4314738 4315562 - 274 15610978 glpQ1 Rv3842c COG0584C I.C.1 nonessential glycerophosphoryl diester phosphodiesterase KEEP 4315563..4315567 4315563 4315567 I NA NA IG3907_Rv3842c-Rv3843c KEEP 4315568..4316596 4315568 4316596 - 342 15610979 - Rv3843c - II.C.5 nonessential transmembrane protein KEEP 4316597..4318774 4316597 4317962 I NA NA IG3908_Rv3843c-Rv3844 KEEP 4316597..4318774 4317963 4318064 I NA NA IG3908_Rv3843c-Rv3844 Annotation + Marin et al 2022 DISCARD 4316597..4318774 4318065 4318101 I NA NA IG3908_Rv3843c-Rv3844 KEEP 4316597..4318774 4318102 4318154 I NA NA IG3908_Rv3843c-Rv3844 Annotation + Marin et al 2022 DISCARD 4316597..4318774 4318155 4318335 I NA NA IG3908_Rv3843c-Rv3844 KEEP 4316597..4318774 4318336 4318774 I NA NA IG3908_Rv3843c-Rv3844 Annotation + Marin et al 2022 DISCARD 4318775..4319266 4318775 4319266 + 163 15610980 - Rv3844 - IV.B.1 phage nonessential transposase Annotation + Marin et al 2022 DISCARD 4319267..4319280 4319267 4319280 I NA NA IG3909_Rv3844-Rv3845 Annotation + Marin et al 2022 DISCARD 4319281..4319640 4319281 4319378 + 119 15610981 - Rv3845 - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 4319281..4319640 4319379 4319640 + 119 15610981 - Rv3845 - VI nonessential hypothetical protein KEEP 4319641..4320703 4319641 4320039 I NA NA IG3910_Rv3845-Rv3846 KEEP 4319641..4320703 4320040 4320112 I NA NA IG3910_Rv3845-Rv3846 Only Marin et al 2022 KEEP 4319641..4320703 4320113 4320703 I NA NA IG3910_Rv3845-Rv3846 KEEP 4320704..4321327 4320704 4321327 + 207 15610982 sodA Rv3846 COG0605P III.F nonessential superoxide dismutase [Fe] SODA KEEP 4321328..4321537 4321328 4321537 I NA NA IG3911_Rv3846-Rv3847 KEEP 4321538..4322071 4321538 4322071 + 177 15610983 - Rv3847 - VI nonessential hypothetical protein KEEP 4322072..4322325 4322072 4322325 I NA NA IG3912_Rv3847-Rv3848 KEEP 4322326..4323234 4322326 4323234 + 302 15610984 - Rv3848 COG2119S II.C.5 nonessential transmembrane protein KEEP 4323235..4323498 4323235 4323498 I NA NA IG3913_Rv3848-Rv3849 KEEP 4323499..4323897 4323499 4323897 + 132 15610985 - Rv3849 - V nonessential hypothetical protein KEEP 4323898..4324014 4323898 4324014 I NA NA IG3914_Rv3849-Rv3850 KEEP 4324015..4324671 4324015 4324671 + 218 15610986 - Rv3850 - V nonessential hypothetical protein KEEP 4324672..4324682 4324672 4324682 I NA NA IG3915_Rv3850-Rv3851 KEEP 4324683..4324967 4324683 4324967 + 94 15610987 - Rv3851 - II.C.5 nonessential hypothetical protein KEEP 4324968..4325073 4324968 4325073 I NA NA IG3916_Rv3851-Rv3852 KEEP 4325074..4325478 4325074 4325478 + 134 15610988 hns Rv3852 - II.A.4 nonessential histone-like protein HNS KEEP 4325479..4325494 4325479 4325494 I NA NA IG3917_Rv3852-Rv3853 KEEP 4325495..4325968 4325495 4325968 + 157 15610989 menG Rv3853 COG0684H I.G.11 nonessential ribonuclease activity regulator protein RraA KEEP 4325969..4326003 4325969 4326003 I NA NA IG3918_Rv3853-Rv3854c KEEP 4326004..4327473 4326004 4327473 - 489 15610990 ethA Rv3854c COG2072P I.B.7 DR-eth nonessential monooxygenase ETHA KEEP 4327474..4327548 4327474 4327548 I NA NA IG3919_Rv3854c-Rv3855 KEEP 4327549..4328199 4327549 4328199 + 216 15610991 ethR Rv3855 COG1309K I.J.1 essential transcriptional regulatory repressor protein (TETR-family) ETHR KEEP 4328200..4328400 4328200 4328400 I NA NA IG3920_Rv3855-Rv3856c KEEP 4328401..4329408 4328401 4329408 - 335 15610992 - Rv3856c COG1387ER V nonessential hypothetical protein KEEP 4329409..4329416 4329409 4329416 I NA NA IG3921_Rv3856c-Rv3857c KEEP 4329417..4329614 4329417 4329614 - 65 15610993 - Rv3857c - II.C.5 nonessential hypothetical protein KEEP 4329615..4330038 4329615 4330038 I NA NA IG3922_Rv3857c-Rv3858c KEEP 4330039..4331505 4330039 4331505 - 488 15610994 gltD Rv3858c COG0493ER I.D.1 essential glutamate synthase subunit beta KEEP 4331498..4336081 4331498 4336081 - 1527 15610995 gltB Rv3859c COG0067E,COG0069E,COG0070E I.D.1 essential ferredoxin-dependent glutamate synthase [NADPH] large subunit KEEP 4336082..4336776 4336082 4336776 I NA NA IG3924_Rv3859c-Rv3860 KEEP 4336777..4337949 4336777 4337949 + 390 15610996 - Rv3860 - V nonessential hypothetical protein KEEP 4337946..4338272 4337946 4338272 + 108 15610997 - Rv3861 - VI nonessential hypothetical protein KEEP 4338171..4338521 4338171 4338521 - 116 15610998 whiB6 Rv3862c COG0343J I.J.1 nonessential transcriptional regulatory protein WHIB-like WHIB6 KEEP 4338522..4338848 4338522 4338848 I NA NA IG3927_Rv3862c-Rv3863 KEEP 4338849..4340027 4338849 4340027 + 392 15610999 - Rv3863 - VI nonessential hypothetical protein KEEP 4340028..4340269 4340028 4340269 I NA NA IG3928_Rv3863-Rv3864 KEEP 4340270..4341478 4340270 4340936 + 402 15611000 - Rv3864 - V essential hypothetical protein KEEP 4340270..4341478 4340937 4340993 + 402 15611000 - Rv3864 - V essential hypothetical protein Only Marin et al 2022 KEEP 4340270..4341478 4340994 4341478 + 402 15611000 - Rv3864 - V essential hypothetical protein KEEP 4341479..4341565 4341479 4341565 I NA NA IG3929_Rv3864-Rv3865 KEEP 4341566..4341877 4341566 4341877 + 103 15611001 - Rv3865 - V nonessential hypothetical protein KEEP 4341878..4341879 4341878 4341879 I NA NA IG3930_Rv3865-Rv3866 KEEP 4341880..4342731 4341880 4342731 + 283 15611002 - Rv3866 - V nonessential hypothetical protein KEEP 4342732..4342769 4342732 4342769 I NA NA IG3931_Rv3866-Rv3867 KEEP 4342770..4343321 4342770 4343321 + 183 15611003 - Rv3867 - V nonessential hypothetical protein KEEP 4343314..4345035 4343314 4345035 + 573 15611004 - Rv3868 COG0464O V essential hypothetical protein KEEP 4345036..4345038 4345036 4345038 I NA NA IG3933_Rv3868-Rv3869 KEEP 4345039..4346481 4345039 4346481 + 480 15611005 - Rv3869 - II.C.5 essential hypothetical protein KEEP 4346481..4348724 4346481 4348718 + 747 15611006 - Rv3870 COG1674D II.C.5 essential transmembrane protein KEEP 4346481..4348724 4348719 4348724 + 747 15611006 - Rv3870 COG1674D II.C.5 essential transmembrane protein Only Marin et al 2022 KEEP 4348725..4348826 4348725 4348826 I NA NA IG3935_Rv3870-Rv3871 Only Marin et al 2022 KEEP 4348827..4350602 4348827 4348834 + 591 15611007 - Rv3871 COG1674D V essential hypothetical protein Only Marin et al 2022 KEEP 4348827..4350602 4348835 4350602 + 591 15611007 - Rv3871 COG1674D V essential hypothetical protein KEEP 4350603..4350744 4350603 4350744 I NA NA IG3936_Rv3871-Rv3872 KEEP 4350745..4351044 4350745 4351044 + 99 57117163 PE35 Rv3872 - VI PE/PPE/PGRS essential PE family-related protein KEEP 4351045..4351074 4351045 4351074 I NA NA IG3937_Rv3872-Rv3873 repeat KEEP 4351075..4352181 4351075 4352181 + 368 57117164 PPE68 Rv3873 - IV.C.1 PE/PPE/PGRS essential PPE family protein KEEP 4352182..4352273 4352182 4352273 I NA NA IG3938_Rv3873-Rv3874 KEEP 4352274..4352576 4352274 4352576 + 100 15611010 esxB Rv3874 - VI nonessential 10 kDa culture filtrate antigen EsxB KEEP 4352577..4352608 4352577 4352608 I NA NA IG3939_Rv3874-Rv3875 KEEP 4352609..4352896 4352609 4352896 + 95 57117165 esxA Rv3875 COG4842S II.C.2 nonessential 6 kDa early secretory antigenic target ESXA (ESAT-6) KEEP 4352897..4353009 4352897 4353009 I NA NA IG3940_Rv3875-Rv3876 KEEP 4353010..4355010 4353010 4353178 + 666 15611012 - Rv3876 COG0455D V essential hypothetical protein KEEP 4353010..4355010 4353179 4353460 + 666 15611012 - Rv3876 COG0455D V essential hypothetical protein Only Marin et al 2022 KEEP 4353010..4355010 4353461 4353838 + 666 15611012 - Rv3876 COG0455D V essential hypothetical protein KEEP 4353010..4355010 4353839 4353891 + 666 15611012 - Rv3876 COG0455D V essential hypothetical protein Only Marin et al 2022 KEEP 4353010..4355010 4353892 4355010 + 666 15611012 - Rv3876 COG0455D V essential hypothetical protein KEEP 4355007..4356542 4355007 4356542 + 511 15611013 - Rv3877 - II.C.5 essential transmembrane protein KEEP 4356543..4356692 4356543 4356692 I NA NA IG3942_Rv3877-Rv3878 KEEP 4356693..4357535 4356693 4357535 + 280 15611014 - Rv3878 - V nonessential hypothetical protein KEEP 4357536..4357592 4357536 4357592 I NA NA IG3943_Rv3878-Rv3879c KEEP 4357593..4359782 4357593 4359133 - 729 15611015 - Rv3879c - VI nonessential hypothetical protein KEEP 4357593..4359782 4359134 4359135 - 729 15611015 - Rv3879c - VI nonessential hypothetical protein Only Marin et al 2022 KEEP 4357593..4359782 4359136 4359782 - 729 15611015 - Rv3879c - VI nonessential hypothetical protein KEEP 4359783..4360198 4359783 4360198 I NA NA IG3944_Rv3879c-Rv3880c KEEP 4360199..4360546 4360199 4360546 - 115 15611016 - Rv3880c - V nonessential hypothetical protein KEEP 4360543..4361925 4360543 4361057 - 460 15611017 - Rv3881c - V nonessential hypothetical protein KEEP 4360543..4361925 4361058 4361100 - 460 15611017 - Rv3881c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4360543..4361925 4361101 4361925 - 460 15611017 - Rv3881c - V nonessential hypothetical protein KEEP 4361926..4362031 4361926 4362031 I NA NA IG3946_Rv3881c-Rv3882c KEEP 4362032..4363420 4362032 4363420 - 462 15611018 - Rv3882c - II.C.5 essential hypothetical protein KEEP 4363417..4364757 4363417 4364757 - 446 15611019 mycP1 Rv3883c COG1404O II.B.3 nonessential membrane-anchored mycosin MYCP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1) KEEP 4364758..4364978 4364758 4364978 I NA NA IG3948_Rv3883c-Rv3884c KEEP 4364979..4366838 4364979 4366838 - 619 15611020 - Rv3884c COG0464O VI nonessential CBXX/CFQX family protein KEEP 4366839..4366907 4366839 4366907 I NA NA IG3949_Rv3884c-Rv3885c KEEP 4366908..4368521 4366908 4368521 - 537 15611021 - Rv3885c - II.C.5 nonessential hypothetical protein KEEP 4368518..4370170 4368518 4368617 - 550 15611022 mycP2 Rv3886c COG1404O II.B.3 nonessential alanine and proline rich membrane-anchored mycosin KEEP 4368518..4370170 4368618 4368637 - 550 15611022 mycP2 Rv3886c COG1404O II.B.3 nonessential alanine and proline rich membrane-anchored mycosin Only Marin et al 2022 KEEP 4368518..4370170 4368638 4369563 - 550 15611022 mycP2 Rv3886c COG1404O II.B.3 nonessential alanine and proline rich membrane-anchored mycosin KEEP 4368518..4370170 4369564 4369624 - 550 15611022 mycP2 Rv3886c COG1404O II.B.3 nonessential alanine and proline rich membrane-anchored mycosin Only Marin et al 2022 KEEP 4368518..4370170 4369625 4370170 - 550 15611022 mycP2 Rv3886c COG1404O II.B.3 nonessential alanine and proline rich membrane-anchored mycosin KEEP 4370155..4371684 4370155 4371684 - 509 15611023 - Rv3887c - II.C.5 nonessential transmembrane protein KEEP 4371681..4372706 4371681 4372706 - 341 15611024 - Rv3888c COG0455D,COG3640D II.C.4 nonessential hypothetical protein KEEP 4372707..4372799 4372707 4372799 I NA NA IG3953_Rv3888c-Rv3889c KEEP 4372800..4373630 4372800 4373630 - 276 15611025 - Rv3889c - VI nonessential hypothetical protein KEEP 4373631..4373725 4373631 4373725 I NA NA IG3954_Rv3889c-Rv3890c KEEP 4373726..4374013 4373726 4374013 - 95 15611026 esxC Rv3890c COG4842S VI nonessential ESAT-6 like protein ESXC (ESAT-6 like protein 11) KEEP 4374014..4374048 4374014 4374048 I NA NA IG3955_Rv3890c-Rv3891c KEEP 4374049..4374372 4374049 4374372 - 107 15611027 esxD Rv3891c - VI nonessential ESAT-6 like protein EsxD KEEP 4374373..4374483 4374373 4374483 I NA NA IG3956_Rv3891c-Rv3892c KEEP 4374484..4375683 4374484 4375683 - 399 57117166 PPE69 Rv3892c - IV.C.1 PE/PPE/PGRS nonessential PPE family protein KEEP 4375684..4375761 4375684 4375761 I NA NA IG3957_Rv3892c-Rv3893c repeat KEEP 4375762..4375995 4375762 4375995 - 77 57117167 PE36 Rv3893c - IV.C.1 PE/PPE/PGRS nonessential PE family protein KEEP 4375996..4376261 4375996 4376261 I NA NA IG3958_Rv3893c-Rv3894c KEEP 4376262..4380452 4376262 4380452 - 1396 15611030 - Rv3894c COG1674D II.C.5 nonessential hypothetical protein KEEP 4380453..4381940 4380453 4381940 - 495 15611031 - Rv3895c - II.C.4 nonessential hypothetical protein KEEP 4381941..4381942 4381941 4381942 I NA NA IG3960_Rv3895c-Rv3896c KEEP 4381943..4382851 4381943 4382851 - 302 15611032 - Rv3896c COG3953R IV.A nonessential hypothetical protein KEEP 4382852..4383007 4382852 4383007 I NA NA IG3961_Rv3896c-Rv3897c KEEP 4383008..4383640 4383008 4383308 - 210 15611033 - Rv3897c - V nonessential hypothetical protein KEEP 4383008..4383640 4383309 4383359 - 210 15611033 - Rv3897c - V nonessential hypothetical protein Only Marin et al 2022 KEEP 4383008..4383640 4383360 4383640 - 210 15611033 - Rv3897c - V nonessential hypothetical protein KEEP 4383641..4383652 4383641 4383652 I NA NA IG3962_Rv3897c-Rv3898c KEEP 4383653..4383985 4383653 4383985 - 110 15611034 - Rv3898c - V nonessential hypothetical protein KEEP 4383986..4384146 4383986 4384146 I NA NA IG3963_Rv3898c-Rv3899c KEEP 4384147..4385379 4384147 4385379 - 410 15611035 - Rv3899c - V nonessential hypothetical protein KEEP 4385373..4386308 4385373 4386308 - 311 15611036 - Rv3900c - V nonessential hypothetical protein KEEP 4386309..4386364 4386309 4386364 I NA NA IG3965_Rv3900c-Rv3901c KEEP 4386365..4386814 4386365 4386814 - 149 15611037 - Rv3901c - II.C.5 nonessential hypothetical protein KEEP 4386815..4387364 4386815 4387364 I NA NA IG3966_Rv3901c-Rv3902c KEEP 4387365..4387895 4387365 4387895 - 176 15611038 - Rv3902c - VI nonessential hypothetical protein KEEP 4387892..4390432 4387892 4390432 - 846 15611039 - Rv3903c - VI nonessential hypothetical protein KEEP 4390433..4390436 4390433 4390436 I NA NA IG3968_Rv3903c-Rv3904c KEEP 4390437..4390709 4390437 4390709 - 90 15611040 esxE Rv3904c - VI nonessential hypothetical protein KEEP 4390710..4390719 4390710 4390719 I NA NA IG3969_Rv3904c-Rv3905c KEEP 4390720..4391031 4390720 4391031 - 103 15611041 esxF Rv3905c COG4842S VI nonessential hypothetical protein KEEP 4391032..4391096 4391032 4391096 I NA NA IG3970_Rv3905c-Rv3906c KEEP 4391097..4391606 4391097 4391606 - 169 15611042 - Rv3906c - V nonessential hypothetical protein KEEP 4391607..4391630 4391607 4391630 I NA NA IG3971_Rv3906c-Rv3907c KEEP 4391631..4393073 4391631 4393073 - 480 57117168 pcnA Rv3907c COG0617J II.A.7 essential poly(A) polymerase KEEP 4393074..4393448 4393074 4393448 I NA NA IG3972_Rv3907c-Rv3908 KEEP 4393449..4394195 4393449 4394195 + 248 15611044 - Rv3908 COG0494LR V nonessential hypothetical protein KEEP 4394192..4396600 4394192 4396600 + 802 15611045 - Rv3909 - V nonessential hypothetical protein KEEP 4396597..4400151 4396597 4400151 + 1184 15611046 - Rv3910 COG0515RTKL,COG0728R II.C.5 essential transmembrane protein KEEP 4400152..4400185 4400152 4400185 I NA NA IG3975_Rv3910-Rv3911 KEEP 4400186..4400854 4400186 4400854 + 222 15611047 sigM Rv3911 COG1595K II.A.7 nonessential RNA polymerase sigma factor SigM KEEP 4400855..4400869 4400855 4400869 I NA NA IG3976_Rv3911-Rv3912 KEEP 4400870..4401634 4400870 4401634 + 254 15611048 - Rv3912 - VI nonessential hypothetical protein KEEP 4401635..4401727 4401635 4401727 I NA NA IG3977_Rv3912-Rv3913 KEEP 4401728..4402735 4401728 4402735 + 335 15611049 trxB2 Rv3913 COG0492O I.G.10 essential thioredoxin reductase TRXB2 KEEP 4402732..4403082 4402732 4403082 + 116 15611050 trxC Rv3914 COG0526OC I.G.10 nonessential thioredoxin trxC (TRX) (MPT46) KEEP 4403083..4403191 4403083 4403191 I NA NA IG3979_Rv3914-Rv3915 KEEP 4403192..4404412 4403192 4404412 + 406 57117169 - Rv3915 COG0860M,COG3409M II.B.4 essential hydrolase KEEP 4404413..4404432 4404413 4404432 I NA NA IG3980_Rv3915-Rv3916c KEEP 4404433..4405167 4404433 4405167 - 244 15611052 - Rv3916c - V nonessential hypothetical protein KEEP 4405168..4405456 4405168 4405456 I NA NA IG3981_Rv3916c-Rv3917c KEEP 4405457..4406491 4405457 4406491 - 344 57117170 parB Rv3917c COG1475K III.C essential chromosome partitioning protein ParB KEEP 4406488..4407531 4406488 4407531 - 347 57117171 parA Rv3918c COG1192D III.C essential chromosome partitioning protein ParA KEEP 4407528..4408202 4407528 4408202 - 224 15611055 gidB Rv3919c COG0357M III.C DR-sm nonessential glucose-inhibited division protein B KEEP 4408203..4408333 4408203 4408333 I NA NA IG3984_Rv3919c-Rv3920c KEEP 4408334..4408897 4408334 4408897 - 187 15611056 - Rv3920c COG1847R VI nonessential hypothetical protein KEEP 4408898..4408968 4408898 4408968 I NA NA IG3985_Rv3920c-Rv3921c KEEP 4408969..4410069 4408969 4410069 - 366 15611057 - Rv3921c COG0706U II.C.5 essential putative inner membrane protein translocase component YidC KEEP 4410053..4410415 4410053 4410415 - 120 15611058 - Rv3922c COG0759S IV.A nonessential hypothetical protein KEEP 4410412..4410762 4410412 4410762 - 116 161352458 rnpA Rv3923c COG0594J II.B.1 essential ribonuclease P KEEP 4410763..4410785 4410763 4410785 I NA NA IG3988_Rv3923c-Rv3924c KEEP 4410786..4410929 4410786 4410929 - 47 15611060 rpmH Rv3924c COG0230J II.A.1 nonessential 50S ribosomal protein L34 KEEP 4410929..4411532 4410929 4411532 I NA NA IG3989_Rv3924c_end KEEP